Search Results
Results 701 - 750 of 3015
< 10 11 12 13 14 15 16 17 18 19 20 >
Du Lin - - 2012
An uncommon 2,5-diarylcyclopentenone compound, preussidone (1), and a new biphenyl compound, 1',5-dimethoxy-3,5'-dimethyl-2,3'-oxybiphenyl-1,2'-diol (4), together with two known biphenyl compounds, 5-methoxy-3,5'-dimethyl-2,3'-oxybiphenyl-1,1',2'-triol (2) and cyperin (3), were obtained from a Preussia typharum isolate that was procured using a panel of unconventional media formulations. The structures of the new compounds were established by ...
Schmidt Bernd M - - 2012
With great stacking comes great conductivity: Trifluoromethylated corannulenes are unexpectedly strong electron acceptors in solution. Even a polycrystalline film of 1,2-(F(3) C)(2) -corannulene (top structure and curve in the plot) exhibits conductivity three orders of magnitude higher than that of pristine corannulene!
Miller Bernard V BV 3rd Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, Saint Louis, MO 63110, - - 2012
Type 2 diabetes mellitus (T2DM) is associated with increased plasma triglyceride (TG) concentrations, but African Americans (AA) have lower plasma TG than Caucasians (CC). We evaluated the hypothesis that obese AA women have lower plasma TG than obese CC women do because of differences in lipid kinetics. Eleven AA and ...
Lee Sun Eun - - 2012
OBJECTIVE: To provide a better understanding of dietary intakes of pregnant women in low- and middle-income countries. DESIGN: Systematic review was performed to identify relevant studies which reported nutrient intakes or food consumption of pregnant women in developing countries. Macronutrient and micronutrient intakes were compared by region and the FAO/WHO ...
Yoshikawa Reigetsu - - 2012
ABSTRACT: BACKGROUND: The polycomb group (PcG) family BMI1, acting downstream of the hedgehog (Hh) pathway, plays an essential role in the self-renewal of haematopoietic, neural, and intestinal stem cells, and is dysregulated in many types of cancer. Our recent report has demonstrated that Hh signalling activation can predict very earlier ...
Takei Yodai Y Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, - - 2012
The chaperonin, GroEL, is an essential molecular chaperone that mediates protein folding together with its cofactor, GroES, in Escherichia coli. It is widely believed that the two rings of GroEL alternate between the folding active state coupled to GroES binding during the reaction cycle. In other words, an asymmetric GroEL-GroES ...
Schmidt Markus A - - 2012
Optical nanosensors based on plasmonic nanoparticles have great potential for chemical and biological sensing applications, but their spectral detection resolution is severely constrained by their broad resonance linewidth, and their spatial sensing depth is limited to several tens of nanometres. Here we demonstrate that coupling a strong dipolar plasmonic resonance ...
Pavord Ian D - - 2012
The identification of phenotypes of asthma has a long history, but previous classifications have not identified clinically important differences in pathology, natural history, or treatment response. Progress has accelerated recently, fueled by the development of new techniques to assess airway disease, particularly noninvasive techniques to assess airway inflammation. This article ...
Tsatalas Themistoklis - - 2012
Abstract This study investigated the effects of knee localised muscle damage on running kinematics at varying speeds. Nineteen young women (23.2 ± 2.8 years; 164 ± 8 cm; 53.6 ± 5.4 kg), performed a maximal eccentric muscle damage protocol (5 × 15) of the knee extensors and flexors of both legs at 60 rad · s(-1). Lower body kinematics was assessed ...
Merstorf Céline - - 2012
Being able to differentiate local fluctuations from global folding/unfolding dynamics of a protein is of major interest for better understanding structure/function determinants. The maltose binding protein (MBP), a protein that belongs to the maltose transport system, has a structure composed of two globular domains separated by a rigid-body "hinge-bending". Here, ...
Hartwig Isabel R V - - 2013
Are maternal progesterone levels in early pregnancy associated with fetal birthweight? Low levels of first-trimester maternal progesterone are significantly associated with a reduction in birthweight in girls, but not boys. Progesterone in the third trimester of pregnancy has previously been related to birthweight in humans. Pregnant women between gestational weeks ...
Merrill Tl - - 2012
Therapeutic hypothermia can reduce both ischemic and reperfusion injury arising after strokes and heart attacks. New localized organ cooling systems offer a way to reduce tissue damage more effectively with fewer side effects. To assess initial blood safety of our new organ cooling system, the CoolGuide Cooling System (CCS), we ...
Jang Kerry L - - 2012
The University of British Columbia (UBC) Twin Project is a registry of approximately 2,000 pairs of reared-together twins recruited across the major Canadian provinces. The focus of the project is an investigation of the behavioral genetics of personality and its disorders, and their relationship to other forms of mental illness. ...
Reuter R R - - 2012
Stocker cattle production practices may affect subsequent performance of cattle in economically meaningful ways. Literature was reviewed to summarize possible carryover effects of stocker cattle management on finishing performance and carcass traits. The most consistent effects of stocker phase practices on finishing-phase and carcass performance of cattle appear to be ...
Trinh Van Anh - - 2012
Ipilimumab, a fully human anti-CTLA-4 antibody, has been approved for the treatment of unresectable or metastatic melanoma based on its survival benefit demonstrated in randomized phase III studies. The current approved dosing schedule of ipilimumab is 3 mg/kg as a 90-min intravenous infusion every 3 weeks for a total of 4 ...
Ndrepepa Gjin - - 2012
BACKGROUND: THE OPTIMAL ANTITHROMBOTIC THERAPY FOR PATIENTS WITH NONST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PERCUTANEOUS CORONARY INTERVENTION IS NOT WELL DEFINED. WE INVESTIGATED THE EFFICACY AND SAFETY OF BIVALIRUDIN VERSUS HEPARIN PLUS A GLYCOPROTEIN IIB/IIIA INHIBITOR (GPI) IN PATIENTS WITH NONST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PERCUTANEOUS CORONARY INTERVENTION AFTER CLOPIDOGREL PRETREATMENT.METHODS ...
Salvador Jorge A R - - 2012
Covering: up to December 2011This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids ...
Singh Dependra Narayan - - 2012
BACKGROUND AND OBJECTIVE: Intraoperative parathyroid hormone (IOPTH) kinetics and therefore the efficacy of IOPTH utilization as a predictor of cure are likely to be affected by baseline IOPTH levels, vitamin D deficiency and parathyroid weight. PATIENTS AND METHODS: Consecutive subjects with primary hyperparathyroidism (PHPT, n=51) undergoing parathyroidectomy with IOPTH monitoring ...
Moravec Frantisek - - 2012
Abstract A new nematode species, Rhabdochona (Rhabdochona) hypsibarbi n. sp. (Rhabdochonidae), is described from the intestine of the freshwater cyprinid fish Hypsibarbus wetmorei (Smith) in the Mekong River, Nakhon Phanom Province, northeast Thailand. It is mainly characterized by medium-sized, bifurcate deirids, the presence of 14 anterior prostomal teeth and of ...
Richardson Amanda - - 2012
OBJECTIVE: As the third most popular website in the world, messages embedded in the video-sharing site, YouTube, have the potential to influence tobacco-related attitudes, beliefs and behaviours. Despite the growing number of videos depicting little cigars/cigarillos (LCCs), there has been no examination of the portrayal of these products on YouTube. ...
Mestre Maria Belén MB Laboratorio de Biología Celular y Molecular, Instituto de Histología y Embriología (IHEM), Facultad de Ciencias Médicas, Universidad Nacional de Cuyo-CONICET, Mendoza, - - 2012
Staphylococcus aureus is an intracellular bacterium responsible for serious infectious processes. This pathogen escapes from the phagolysosomal pathway into the cytoplasm, a strategy that allows intracellular bacterial replication and survival with the consequent killing of the eukaryotic host cell and spreading of the infection. S. aureus is able to secrete ...
Yoon Hun-Young - - 2012
We report here the clinical presentation and successful surgical management of synovial hemangioma accompanied by cruciate ligament injury in a dog. Surgical correction of cruciate ligament injury was performed after removing torn cruciate ligaments, synovial mass and masses attached to the ligaments and distal femoral articular cartilage. At 10 months, ...
Zhuang Chunlin - - 2012
The p53-MDM2 interaction has been approved to be a valuable target to develop effective antitumor agents. Novel p53-MDM2 inhibitors bearing pyrrolidone scaffolds were successfully identified by structure-based design. The nanomolar inhibitor 5 possessed good p53-MDM2 inhibitory activity (Ki = 780 nM) due to its hydrophobic and hydrogen bonding interactions with ...
Prod'hom Sylvain - - 2012
INTRODUCTION: Quitting smoking is associated with weight gain, which may threaten motivation to engage or sustain a quit attempt. The pattern of weight gained by smokers treated according to smoking cessation guidelines has been poorly described. We aimed to determine the weight gained after smoking cessation and its predictors, by ...
Floyd Brice E - - 2012
Autophagy is a macromolecular degradation pathway by which cells recycle their contents as a developmental process, housekeeping mechanism, and response to environmental stress. In plants, autophagy involves the sequestration of cargo to be degraded, transport to the cell vacuole in a double-membrane bound autophagosome, and subsequent degradation by lytic enzymes. ...
Glinianaia Svetlana V - - 2012
The population-based Northern Survey of Twin and Multiple Pregnancy (NorSTAMP, formerly the Multiple Pregnancy Register) has collected data since 1998 on all multiple pregnancies in North of England (UK) from the earliest point of ascertainment in pregnancy. This paper updates recent developments to the NorSTAMP and presents some early mortality ...
Baeg Kang-Jun - - 2012
We report here the development of high-performance p- and n-channel organic field-effect transistors (OFETs) and complementary circuits using inkjet-printed semiconducting layers and high-k polymer dielectric blends of poly(vinylidenefluoride-trifluoroethylene) (P(VDF-TrFE)) and poly(methyl methacrylate) (PMMA). Inkjet-printed p-type polymer semiconductors containing alkyl-substituted thienylenevinylene (TV) and dodecylthiophene (PC12TV12T) and n-type poly{[N,N9-bis(2-octyldodecyl)-naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,59-(2,29-bithiophene)} (P(NDI2OD-T2)) OFETs typically ...
Virchow J Christian - - 2012
Asthma is a chronic inflammatory condition affecting up to 10% of all women of child-bearing age. In most patients asthma can be safely treated during pregnancy. However, asthma crises or exacerbations during pregnancy can be life threatening to both the mother and the child. Uncontrolled asthma has been associated with ...
Baldwin Katherine L - - 2012
During gravitropism, the potential energy of gravity is converted into a biochemical signal. How this transfer occurs remains one of the most exciting mysteries in plant cell biology. New experiments are filling in pieces of the puzzle. In this review, we introduce gravitropism and give an overview of what we ...
Liu Qian - - 2012
Currently, concerns of clopidogrel and proton pump inhibitors (especially omeprazole) interaction are raised, because they are both metabolized by CYP2C19. What is more, omeprazole can also inhibit the activity of CYP2C19. The study was to compare the influence of omeprazole on platelet inhibition of clopidogrel in various CYP2C19 mutant alleles. ...
Farmer Jennifer Lynn - - 2012
The cross-coupling of allylpinacolboronic ester derivatives with aryl and heteroaryl halides occurred with high selectivity (>97%) at the α-carbon of the allylboron reagent in the presence of Pd-PEPPSI-IPent precatalyst and 5M KOH in refluxing THF. In case of trisubstituted E-allylboronates, mi-nor olefin geometry isomerization was observed (E/Z ~ 80/20).
Wong C K E - - 2012
Angiogenesis is one of the hallmarks of cancer driving tumour growth and ultimately metastasis. Circulating endothelial cells (CECs) and circulating endothelial progenitor (CEPs) cells have been reported as candidate surrogate markers for tumour vascularisation. Our aim was to investigate the potential use of these circulating cells levels as predictors of ...
McCann Dustin A - - 2012
A 69 year old white male presented to a tertiary hospital from a skilled nursing facility with malaise, fatigue, night sweats, and a non-productive cough for seven days.. He was a retired Midwestern farmer who lived near a fresh water stream, and a remote former smoker. There had been no ...
Wang Teng - - 2012
Hot couple: Propargyl azides were coupled with carboxylic acids by an iron-catalyzed dehydrogenative CO bond formation. This method enables propargylic C sp 3H functionalization under mild reaction conditions and also may involve the application of the azido moiety as an assisting group in CH activation.
Pollin Reiko - - 2012
Lyssavirus matrix proteins (M) support virus budding and have accessory functions that may contribute to host cell manipulation and adaptation to specific hosts. Here, we show that rabies virus (RABV) and European Bat Lyssavirus Type 1 (EBLV-1) M proteins differ in targeting and accumulation at cellular membranes. In contrast to ...
Tejera Paula P Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, - - 2012
The role of genetics in the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) from direct or indirect lung injury has not been specifically investigated. The aim of this study was to identify genetic variants contributing to ALI/ARDS from pulmonary or extrapulmonary causes. We conducted a multistage genetic ...
Nieters Alexandra A Centre of Chronic Immunodeficiency, University Medical Center Freiburg,Engesser Strasse4, Freiburg, Germany. - - 2012
Many common genetic variants have been associated with non-Hodgkin lymphoma (NHL), but individual study results are often conflicting. To confirm the role of putative risk alleles in B-cell NHL etiology, we performed a validation genotyping study of 67 candidate single nucleotide polymorphisms within InterLymph, a large international consortium of NHL ...
Hatfield Kimberley J - - 2012
Increased bone marrow angiogenesis is seen in several hematological malignancies, including acute myeloid leukemia (AML). We used a co-culture assay of endothelial and vascular smooth muscle cells to investigate the effects of AML-conditioned medium on capillary networks. We investigated primary AML cells derived from 44 unselected patients and observed that ...
Wadsworth Andrew D - - 2012
The total syntheses of the initially reported and revised structures of the neuroprotective agent palmyrolide A are reported. The key macrocyclization step was achieved using a sequential ring closing metathesis/olefin isomerization reaction. The synthetic work described herein serves to confirm the recent structural revision of this unusual natural product.
Nourski Kirill V - - 2012
The place of the posterolateral superior temporal (PLST) gyrus within the hierarchical organization of the human auditory cortex is unknown. Understanding how PLST processes spectral information is imperative for its functional characterization. Pure-tone stimuli were presented to subjects undergoing invasive monitoring for refractory epilepsy. Recordings were made using high-density subdural ...
Nishiyama Ryoji - - 2012
This study examined whether additional articulatory rehearsal induced temporary durability of phonological representations, using a 10-s delayed nonword free recall task. Three experiments demonstrated that cumulative rehearsal between the offset of the last study item and the start of the filled delay (Experiments 1 and 3) and a fixed rehearsal ...
Salem Ahmed F AF The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, - - 2012
Our recent studies have mechanistically demonstrated that cancer-associated fibroblasts (CAFs) produce energy-rich metabolites that functionally support the growth of cancer cells. Also, several authors have demonstrated that DNA instability in the tumor stroma greatly contributes to carcinogenesis. To further test this hypothesis, we stably knocked-down BRCA1 expression in human hTERT-immortalized ...
Qi Xinxin - - 2012
Highly efficient synthesis of 3-hydroxypyridines has been developed based on carbenoid-mediated N-O bond insertion. Treatment of δ-diazo oxime ethers with dirhodium complex Rh(2)(tfacam)(4) rapidly provides a variety of pyridines in 5-10 minutes in good to excellent yields.
Estrada Alejandro - - 2012
Recent assessments by the International Union for Conservation of Nature (IUCN) indicate the existence of about 612 recognized primate species and subspecies (IUCN RedList, 2012), but close to 50% of these taxa are at risk of extinction as a result of human action. In this article, I call attention to ...
Malindretos Pavlos - - 2012
It has been more than 2000 years since Hippocrates described renal disease and observed its progressive nature. Decreased survival and deteriorated health status of these patients' being is attributed to cardiovascular disease. There is increasing interest regarding the impact of non-traditional risk factors, including hyperphosphatemia, elevated calcium-phosphate (CaxPO(4)) product, elevated ...
McCauley Stephen R - - 2012
There is significant heterogeneity in outcomes following mild traumatic brain injury (mTBI). While several host factors (age, gender, preinjury psychiatric history, etc.) have been investigated, the influence of preinjury psychological resilience and mood status in conjunction with mild TBI remains relatively unexplored. Euthymic mood and high resilience are potentially protective ...
Zhang Dong-Mei - - 2012
23-O-(1,4'-bipiperidine-1-carbonyl) betulinic acid (BBA), a synthetic derivative of 23-hydroxybetulinic acid (23-HBA), shows a reversal effect on multidrug resistance (MDR) in our preliminary screening. Overexpression of ATP-binding cassette (ABC) transporters such as ABCB1, ABCG2 and ABCC1 has been reported in recent studies to be a major factor contributing to MDR. Our ...
García-Domínguez Patricia - - 2012
A novel epigenetic modulator that displays a DNMT1 inhibition and DNMT3A activation profile was characterized (compound 8). This compound is a derivative of palmitic acid that incorporates the putative reactive functional group (diynone) of the peyssonenyne natural products. Other analogues containing the diynone or an acetoxyenediyne did not show the ...
Dinglasan Lu Anne V - - 2012
Purpose:To examine filter characteristics at preretrieval computed tomography (CT) that are associated with complicated inferior vena cava (IVC) filter retrieval procedures.Materials and Methods:This study was HIPAA compliant, and informed consent was waived. Institutional review board-approved retrospective review of IVC filter retrievals between January 2002 and July 2011 was performed to ...
Leamy Larry J LJ Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA. - - 2012
Driven by the recent obesity epidemic, interest in understanding the complex genetic and environmental basis of body weight and composition is great. We investigated this by searching for quantitative trait loci (QTLs) affecting a number of weight and adiposity traits in a G(10) advanced intercross population produced from crosses of ...
< 10 11 12 13 14 15 16 17 18 19 20 >