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Xu Zhen - - 2012
Continuous, ultrastrong graphene fibers are achieved by wet-spinning of giant graphene oxide liquid crystals, followed by wet-drawing and ion-cross-linking. The giant size and regular alignment of graphene sheets render the fibers with high mechanical strength and good conductivity. Such graphene fibers promise wide applications in functional textiles, flexible and wearable ...
Varela Rocco R Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94143-0912, - - 2012
Computational approaches for binding affinity prediction are most frequently demonstrated through cross-validation within a series of molecules or through performance shown on a blinded test set. Here, we show how such a system performs in an iterative, temporal lead optimization exercise. A series of gyrase inhibitors with known synthetic order ...
Harjes U U Molecular Oncology Laboratories, University Department of Oncology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, - - 2012
Tumour tissue is characterised by fluctuating oxygen concentrations, decreased nutrient supply, and acidic pH. The primarily glycolytic metabolism of tumour cells contributes to this, with increased glucose consumption and increased lactate secretion. Endothelial cells are particularly challenged when recruited towards the tumour metabolic environment. They are required to proliferate and ...
Callini Elsa - - 2012
Hydrogen desorption from borohydrides is often accompanied by the release of diborane. The amount of diborane released as a byproduct during the decomposition of borohydrides scales inversely with the borohydride stability, which in turn depends on the electronegativity of the corresponding cation. We present a model based on the difference ...
Shishkin Oleg V - - 2012
To understand how deuterium and fluorine substituents influence the supramolecular architecture of pyridine N-oxide crystals, the crystal structure of 3-fluoropyridine N-oxide (PNO-3F) was determined and the crystal packing motives of non-deuterated pyridine-N-oxide (PNO), partial-deuterated pyridine-N-oxide (PNO-D) and PNO-3F were analyzed based on ab initio quantum-chemical calculations of the intermolecular interaction ...
Akpinar Deniz - - 2012
The aim of the study was to investigate the effects of extremely low-frequency electric field (ELF EF) on visual evoked potential (VEP), thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), total oxidant status (TOS), and oxidant stress index (OSI). Thirty female Wistar rats, aged 3 months, were divided into ...
Spadafranca Angela - - 2012
Extracts of Phaseolus vulgaris (beans) are known to reduce glycaemia and food intake in rodents and humans. The present study evaluated the effects of a new, standardised and purified P. vulgaris extract (PVE), when employed as a supplement in a mixed balanced meal (60 % carbohydrates, 25 % lipids and 15 % protein), ...
Jacob Gitta A - - 2012
Background: Both emotion regulation and impulsivity are core aspects of borderline personality disorder (BPD) pathology. Although both problems may be combined specifically in BPD, few studies to date have investigated the emotional modulation of impulsivity in BPD. Methods: Women with BPD and matched healthy controls performed go/no-go tasks after induction ...
Reig-Viader Rita - - 2013
What is the distribution of telomeric repeat-containing RNA (TERRA) and of telomerase in human fetal oocytes? TERRA forms discrete foci at telomeres of human fetal oocytes and it co-localizes with both the shelterin component telomeric repeat-binding factor 2 (TRF2) and the catalytic subunit of human telomerase at the telomeres of ...
Rodriguez Isabel - - 2012
Background: The purpose was to analyze the cardiac and renal capillary density and glomerular morphology that result from a chronic excess or deficiency of thyroid hormones in rats.Methods: We performed histopathological, morphometric and immunohistochemical analyses in hypothyroid and hyperthyroid rats to evaluate the density of mesenteric, renal and cardiac vessels ...
Lund Cathrine - - 2012
ABSTRACT: BACKGROUND: Up to date information on poisoning trends is important. This study reports the epidemiology of all hospitalized acute poisonings in Oslo, including mortality, follow-up referrals, and whether the introduction of over-the-counter sales of paracetamol outside pharmacies had an impact on the frequency of poisonings. METHODS: All acute poisonings ...
Mitsui Yozo - - 2012
What's known on the subject? and What does the study add? The process of bladder regeneration with a bladder acellular matrix graft (BAMG) is thought to be accelerated by administration of vascular endothelial growth factor into the host bladder. In the present study, we showed that simultaneous implantation of bilateral ...
Sattler Wesley - - 2012
[Tris(2-pyridylthio)methyl]zinc hydride, [κ(3)-Tptm]ZnH, is a multifunctional catalyst that is capable of achieving (i) rapid release of hydrogen by protolytic cleavage of silanes with either water or methanol and (ii) hydrosilylation of aldehydes, ketones, and carbon dioxide. For example, [κ(3)-Tptm]ZnH catalyzes the release of 3 equivalents of H(2) by methanolysis of ...
Kelly A K - - 2012
This study evaluated the effect of residual feed intake (RFI) on the expression of constituent genes of the somatotropic axis in skeletal muscle across 2 diverse dietary regimes. Beef heifers (n = 86; initial BW = 191.8 kg [SD = 37]) fed a low-forage (LF) total mixed ration comprised of ...
Roccaro Aldo M - - 2012
The TORC1 inhibitor everolimus has previously shown significant activity as a single agent in hematologic malignancies, with reported responses of 30% to 70% in Waldenstrom macroglobulinemia. However, the specific mechanisms by which this class of mTOR inhibitors exerts anti-Waldenstrom macroglobulinemia activity have not been fully investigated. We therefore sought to ...
Jones Huw B - - 2012
Islets of Langerhans represent a heterogeneous population in insulin resistant and diabetic animals and humans as histological appearances and function vary substantially. Mathematical representation that reflects this morphological diversity will assist in assessment of degeneration and regeneration, enabling comparisons between species, strains, and experimental investigations. Our investigative approach used a ...
Sasaki Kotaro - - 2012
Stability is one of the main requirements for commercializing fuel cell electrocatalysts for automotive applications. Platinum is the best-known catalyst for oxygen reduction in cathodes, but it undergoes dissolution during potential changes while driving electric vehicles, thus hampering commercial adoption. Here we report a new class of highly stable, active ...
Nothwehr Faryle K FK University of Iowa, Iowa City, IA, - - 2013
This study tested a novel intervention to influence restaurant customer ordering behavior, with measurements at baseline and 3, 6, and 12 months postintervention in four owner-operated restaurants in the Midwest. A sample of 141 to 370 customers was surveyed at each time point. The response rate was 70% to 84% ...
Tørring Pernille M - - 2012
Background: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal-dominant vascular disorder with three disease-causing genes identified to date: ENG, ACVRL1, and SMAD4. We report an HHT patient with allelic dropout that on routine sequence analysis for a known mutation in the family (c.817-3T>G in ENG) initially seemed to be homozygous for ...
Lange Kathrin - - 2012
It has been repeatedly shown that the auditory N1 is enhanced for sounds presented at an attended time point. The present study investigated the underlying mechanisms using a temporal cuing paradigm. In each trial, an auditory cue indicated at which time point a second sound could be relevant for response ...
Brunel Lionel - - 2012
The goal of the present study was to find evidence for a multisensory generalization effect (i.e., generalization from one sensory modality to another sensory modality). The authors used an innovative paradigm (adapted from <citationReference id="cr5-1" rid="c5">Brunel, Labeye, Lesourd, & Versace, 2009</citationReference>) involving three phases: a learning phase, consisting in the ...
Cao Xiaopei - - 2012
Abstract Objective: This study identified the impact of intensive therapy on neonatal outcomes in women with gestational diabetes mellitus (GDM) and determined the effects on the postpartum metabolic status of the mothers. Research Design and Methods: In total, 127 pregnant women with GDM were randomly selected to receive an intensive ...
Venkatachalam Kartik - - 2013
Lysosomal storage diseases are metabolic disorders characterized by the accumulation of acidic vacuoles, and are usually the consequence of the deficiency of an enzyme responsible for the metabolism of vesicular lipids, proteins or carbohydrates. In contrast, mucolipidosis type IV (MLIV), results from the absence of a vesicular Ca ( 2+) ...
Yang Tao - - 2012
Quantum-chemical calculations reveal that metallic carbide endohedral fullerene Y(2)C(2)@C(84) possesses a novel fullerene cage, C(1)(51383)-C(84), with one pair of pentagon adjacencies. One of the encapsulated yttrium atoms is located on the adjacent pentagons, while the other stays on a hexagonal ring in the fullerene cage. As one of numerous metallic ...
Balkrishna Shah Jaimin - - 2012
Isoselenazolones were synthesized by a copper-catalyzed Se-N bond forming reaction between 2-halobenzamides and selenium powder. The catalytic activity of the various isoselenazolones was studied in the bromolactonization of pent-4-enoic acid. Isoselenazolone 9 was studied as a catalyst in several reactions: the bromolactonization of a series of alkenoic acids with bromine ...
Ali Farzana Nawaz - - 2012
The generalized term 'peripheral vascular disease' (PVD) may be used to refer to vascular disorders in any non-coronary arterial bed. The more specific term 'peripheral arterial disease' (PAD) is used to refer to a more specific process, atherosclerotic disease of the lower extremities. PAD is common. Conservative estimates suggest more ...
Amábile-Cuevas Carlos F - - 2012
The emergence and spread of antibiotic-resistant bacteria reflects both, a gradual, completely Darwinian evolution, which mostly yields slight decreases in antibiotic susceptibility, along with phenotypes that are not precisely characterized as "resistance"; and sudden changes, from full susceptibility to full resistance, which are driven by a vast array of horizontal ...
Chen Pengyu - - 2012
The effects of ZnO nanoparticles (NPs) interacting with single-celled green algae, Chlorella sp., have been found to be bilateral. Specifically, our electron microscopy, plant cell, and fluorescence assays showed that the adsorption and aggregation of ZnO NPs compromised algal cell morphology, viability and membrane integrity, resulting from zinc ion dissolution ...
Gultepe Evin E Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, - - 2013
Thermally activated, untethered microgrippers can reach narrow conduits in the body and be used to excise tissue for diagnostic analyses. As depicted in the figure, the feasibility of an in vivo biopsy of the porcine bile duct using untethered microgrippers is demonstrated.
Högfeldt T - - 2012
ABSTRACT DLBCL non-Hodgkin's lymphoma is a heterogeneous disease with an association to inflammation and viral infections. We hypothesize that environmental factors may be involved in the pathogenesis of DLBCL. In this study, we compared gene expression profiles of lymph node tissues from DLBCL patients from two different geographical areas with ...
Golobič Miha - - 2012
The fate of nanoparticles in organisms is of significant interest. In the current work, we used a test system with terrestrial isopods (Porcelio scaber) fed with food spiked with Cu NPs or soluble Cu salt for 14 days. Two different doses were used for spiking to yield final concentrations of ...
Guo Jinrui - - 2012
Gold nanoparticles encapsulated in porous carbon spheres with high surface areas (∼800 m(2) g(-1)) have been synthesized by ultrasonic spray pyrolysis (USP). The porous carbon-encapsulated gold nanoparticles exhibit excellent catalytic activity toward the reductions of both hydrophilic and hydrophobic nitroaromatics.
Semenov S - - 2012
The aim of the current work is to present results of computer simulations, which show influence of kinetic effects on evaporation of pinned sessile water droplets of submicron size placed on a heat conductive substrate. The computer simulation model takes also into account the following phenomena: influence of curvature of ...
Boido Davide - - 2012
Seizure patterns in temporal lobe epilepsies have been described both in humans and in animal models. The involvement of specific hippocampal-parahippocampal subregions in the initiation and progression of temporal lobe seizures is not defined yet. We analyzed limbic network dynamics during seizures induced by 3-min arterial perfusion of 50 µM ...
Chuang Chi-Ning - - 2012
Red1, Hop1 and Mek1 are three yeast meiosis-specific chromosomal proteins that uphold the interhomolog (IH) bias of meiotic recombination. Mek1 is also an effector protein kinase in a checkpoint that responds to aberrant DNA and/or axis structure. The activation of Mek1 requires Red1-dependent Hop1-Thr(T)318 phosphorylation, which is mediated by Mec1 ...
Mondal Avijit - - 2012
Graphene-based composites offer enhanced catalytic performance of metal and semiconductor nanoparticles, but their development is challenging because catalytic performance strongly depends on the structure and composition of the composite. Herein we show that the catalytic performance of a nanoparticle-graphene composite is very dependent on catalyst loading, which can be optimized ...
Mei Shilin - - 2012
Block-copolymer (BCP) nanospheres with hierarchical inner structure are of great interest and importance due to their possible applications in nanotechnology and biomedical engineering. Mesoporous BCP nanospheres with multilayered inner channels are considered as potential drug-delivery systems and templates for multifunctional nanomaterials. Selective swelling is a facile pore-making strategy for BCP ...
Farahini Hossein - - 2012
Necrosis and apoptosis caused by ischaemia-reperfusion (IR) result in myocyte death and atrophy. ATP-sensitive K(+) (K(ATP) ) channels activation increases tissue tolerance of IR-injury. Thus, in the present study, we evaluated the effects of K(ATP) channel activation on skeletal muscle apoptosis after IR. Male Wistar rats were treated with 40 ...
Yashchenok Alexey - - 2012
Gold nanoparticle aggregate carbon nanotube functionalized colloidal particles serve as an efficient platform for probing the intracellular environment. The probes provide the means of effective localization of signal and detection of molecular fingerprints of biomolecules in living cells. The approach demonstrated in this work opens significant opportunities in molecular imaging ...
Cao Hai - - 2012
The organogel formation and self-assembly of a glycine based achiral molecule was investigated. It has been found that the compound could gel organic solvents either at a lower temperature with lower concentration or at room temperature with higher concentration, which showed different self-assembled nanostructures. At a low temperature of -15 ...
Tsai Yun-Ta - - 2012
We report a female infant with presentation of epignathus teratoma involving duplication of both the mandible and tongue. Epignathus with duplication of the mandible has rarely been reported in the literature thus far. The location and extent of the tumor, as well as the involvement of adjacent structures, resulted in ...
Kandler Christian - - 2012
The Bielefeld Longitudinal Study of Adult Twins (BiLSAT) is a German longitudinal study of monozygotic and dizygotic twins reared together, including more than 1,100 twin pairs aged between 14 and 80 who participated in the first wave. Data were collected at five waves of assessment between 1993 and 2009. Initially, ...
Vázquez-Vázquez Adriana - - 2012
Summary Variation in height among young adults has been linked to the living conditions of different social groups. The aim of this study was to measure variation in the height and knee height of young adults by head of household employment level and family income. The sample comprised 180 individuals ...
Partsvania B - - 2012
During exposure to the cell phone electromagnetic field (EMF), some neurons in the brain at areas of peak specific absorption rate (SAR) absorb more electromagnetic energy than is permitted by existing guidelines. The goal of the present work was to investigate the influence of cell phone-like EMF signal on excitability ...
Mellett Mark - - 2012
Interleukin-17A, the prototypical member of the interleukin-17 cytokine family, coordinates local tissue inflammation by recruiting neutrophils to sites of infection. Dysregulation of interleukin-17 signalling has been linked to the pathogenesis of inflammatory diseases and autoimmunity. The interleukin-17 receptor family members (A-E) have a broad range of functional effects in immune ...
Van der Burg Erik - - 2012
In the present study we investigated whether a task-irrelevant distractor can induce a visual attentional blink pattern. Participants were asked to detect only a visual target letter (A, B, or C) and to ignore the preceding auditory, visual, or audiovisual distractor. An attentional blink was observed regardless of the distractor ...
Unnithan Viswanath - - 2012
Abstract The purpose of this review article was firstly to evaluate the traditional approach to talent identification in youth soccer and secondly present pilot data on a more holistic method for talent identification. Research evidence exists to suggest that talent identification mechanisms that are predicated upon the physical (anthropometric) attributes ...
Dow Belinda L - - 2012
Although there is some information available regarding the utility of the Children's Revised Impact of Event Scale (CRIES) in screening for posttraumatic stress disorder (PTSD), data are scarce and limited to studies sampling children predominantly injured in road traffic accidents. This study investigated the utility of 2 versions, the CRIES-8 ...
Owens David R - - 2012
Several biopharmaceuticals, including insulin and insulin analogs, are, or shortly will be, off-patent, thereby providing an opportunity for companies to attempt to manufacture "copies" commonly referred to as biosimilars and also known as follow-on biologics. Reassurance that such copy biologics are equally safe and effective as the conventional products is ...
Zhang Jie-Peng - - 2012
The two-step N(2) adsorption behaviour of sodalite-type Zn(ii) 2-methylimidazolate and 3-methyl-1,2,4-triazolate has been comprehensively and accurately elucidated.
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