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Hakeem Khalid Rehman - - 2012
Abstract Plant growth and productivity are influenced by various abiotic stresses. Stressful conditions may lead to delays in seed germination, reduced seedling growth, and decreased crop yields. Plants respond to environmental stresses via differential expression of a subset of genes, which results in changes in omic compositions, such as transcriptome, ...
Li Weihui - - 2012
In a bis-(3'-5')-cyclic dimeric guanosine monophosphate (c-di-GMP)/transcription factor binding screen, we identified Mycobacterium smegmatis Ms6479 as the first c-di-GMP-responsive transcriptional factor in mycobacteria. Ms6479 could specifically bind with c-di-GMP and recognize the promoters of 37 lipid transport and metabolism genes. c-di-GMP could enhance the ability of Ms6479 to bind to ...
Andolfi Anna - - 2012
Two isolates of Neofusicoccum australe belonging to ITS haplotypes H4 and H1 and associated with grapevine cordon dieback and branch dieback of Phoenicean juniper, respectively, have been shown to produce in vitro structurally different secondary metabolites. From the strain BOT48 of N. australe (haplotype H4) a new cyclohexenone oxide, namely, ...
Murgiano Leonardo - - 2012
ABSTRACT: BACKGROUND: Bovine congenital pseudomyotonia (PMT) is an impairment of muscle relaxation induced by exercise preventing animals from performing rapid movements. Forms of recessively inherited PMT have been described in different cattle breeds caused by two independent mutations in ATP2A1 encoding a skeletal-muscle Ca2+-ATPase (SERCA1). We observed symptoms of congenital ...
Switlyk Md - - 2012
BackgroundMagnetic resonance imaging (MRI) is the recommended primary investigation method for metastatic spinal cord compression (MSCC). Initiating treatment before the development of motor deficits is essential to preserve neurological function. However, the relationship between MRI-assessed grades of spinal metastatic disease and neurological status has not been widely investigated.PurposeTo analyze the ...
Hu Guoping - - 2012
This study aims to identify inhibitors that bind at the interface of HIV-1 integrase and human LEDGF/p75, which represents a novel target for anti-HIV therapy. To date, only a few such inhibitors have been reported. Here structure-based virtual screening was performed to search for the inhibitors from an in-house library ...
Ralston Shawn - - 2012
BACKGROUND: Acute viral bronchiolitis is the most common diagnosis resulting in hospital admission in pediatrics. Utilization of non-evidence-based therapies and testing remains common despite a large volume of evidence to guide quality improvement efforts. OBJECTIVE: Our objective was to reduce utilization of unnecessary therapies in the inpatient care of bronchiolitis ...
Randall J - - 2012
Background. Human rights violations are commonly experienced by people in psychiatric and social care institutions. States and private organizations providing such health and social services must comply with international human rights law. Monitoring of such compliance is increasingly recognized as a vital component in ensuring that rights are respected and ...
Meijer Rick I RI Department of Internal Medicine, VU University Medical Center, Amsterdam, The - - 2013
Microvascular recruitment in muscle is a determinant of insulin sensitivity. Whether perivascular adipose tissue (PVAT) is involved in disturbed insulin-induced vasoreactivity is unknown, as are the underlying mechanisms. This study investigates whether PVAT regulates insulin-induced vasodilation in muscle, the underlying mechanisms, and how obesity disturbs this vasodilation. Insulin-induced vasoreactivity of ...
Reid E D - - 2012
Early detection of disease can speed treatment, slow the spread of disease in a herd, and improve the health status of animals. Immune stimulation elevates rectal temperature (RT). Injectable radio frequency implants (RFI) can provide temperature at the site of implantation. The fidelity of peripheral site temperature, determined by RFI, ...
Y Wang Christina - - 2012
Objective: To review immunologic contact urticaria (ICU) in the occupational and environmental context, and describe its continued relevance in light of the ever-increasing onslaught of new chemicals and products, as well as new technology placing novel interactions, such as nanoparticles, within reach of the population at home and work. Methods: ...
Tobe Makoto - - 2012
OBJECTIVE The National Health Insurance Program (NHIP) in the Philippines is a social health insurance system partially subsidized by tax-based financing which offers benefits on a fee-for-service basis up to a fixed ceiling. This paper quantifies the extent to which beneficiaries of the NHIP incur out-of-pocket expenses for inpatient care, ...
Giesing Michael - - 2012
What's known on the subject? and What does the study add? The role of circulating cancer cells in metastogenesis is generally accepted. Two forms of these cells have been reported in a number of studies, cancer cell clusters (CCCs) and individual epithelial cancer cells. Clusters appear at higher frequencies in ...
Foresta C - - 2012
Background: Recent data suggest a potential role of testis in vitamin D activation, where Leydig cells could represent key players in this process since they express the highest amount of CYP2R1, a key enzyme involved in vitamin D 25- hydroxylation. Aim: To evaluate bone status in unilateral orchiectomy and to ...
Lotta Ingrid Astrid - - 2012
Abstract Leucocytozoon spp. infections have been rarely studied in Neotropical countries. The apparent low prevalence of these parasites compared to the Nearctic regions, suggests the absence of competent vectors in this geographical region; however a 21.3% overall prevalence has recently been reported in non-migratory birds from the paramo region of ...
Costa Paolo - - 2012
Cerebral vein thrombosis (CVT) is a rare complication of spontaneous intracranial hypotension (SIH). When to suspect a thrombotic disorder during the course of intracranial hypotension is not fully elucidated. A 48-year-old woman was admitted because of SIH with no signs of CVT on neuroimaging. The occurrence of diplopia and blurred ...
Sun Miao - - 2012
Here we tested the hypothesis that excess maternal androgen in late pregnancy reduces placental and fetal growth, increases placental steroidogenesis, and adversely affects glucose and lipid metabolism in adult female offspring. Pregnant Wistar rats were randomly assigned to treatment with testosterone (daily injections of 5 mg free testosterone from gestational ...
Starling Jean - - 2012
Objective:This study aims to describe the clinical course of psychotic disorders, including the premorbid history, symptoms and level of functioning in a group of children and adolescents treated by paediatric mental health services, mainly as inpatients.Method:A sample of 45 children and adolescents with a psychotic disorder (mean age 13.2 years) ...
Liu Lianliang - - 2012
Cardiovascular protective functions of bamboo shoot ACE inhibitory peptide (BSP) from bamboo shoot were evaluated, including anti-hypertensive effect on spontaneously hypertensive rats (SHRs) and anti-hyperlipidemic effect on high-fat diet-induced rats. 30 days anti-hypertensive effects of BSP on SHRs were assayed. Asp-Tyr (10 mg/day kg BW) and BSP (50 mg/day kg ...
Awasthi Niranjan - - 2012
Gemcitabine has limited clinical benefits in pancreatic ductal adenocarcinoma (PDAC). Insulin-like growth factor (IGF) signaling proteins are frequently over-expressed in PDAC. The therapeutic potential of BMS-754807, a small molecule inhibitor of IGF-type 1 receptor (IGF-1R) and insulin receptor (IR), and gemcitabine was evaluated in experimental PDAC. Cell proliferation and protein ...
Atanasova Mariya - - 2012
Our understanding of the detailed mechanism of action of cytokine and growth factor receptors - and particularly our quantitative understanding of the link between structure, mechanism and function - lags significantly behind our knowledge of comparable functional protein classes such as enzymes, G protein-coupled receptors, and ion channels. In particular, ...
Tandale Babasaheb V BV National Institute of Virology, Pashan, Pune India. - - 2013
The healthcare workers having seroprotection at 3 weeks (n = 127) following Pandemic H1N1 2009 influenza vaccination were followed up for antibody persistence. Seroprotection at 12 mo (60.2%) was significantly lower as compared with 3 weeks (74.7%), 3 mo (77.8%) and 6 mo (75.4%). The vaccine provided seroprotection up to ...
Elshiekh Mohamed A F MA Department of Cardiothoracic Surgery, Suez Canal University Hospital, Ismailia, - - 2013
A best evidence topic was written according to a structured protocol. The question addressed was whether muscle-sparing thoracotomy (MST), as opposed to posterolateral thoracotomy (PLT), results in better recovery. A total of 108 papers were found using the reported searches of which eight represented the best evidence to answer the ...
Martirosyan Varsik - - 2012
In the present work, the frequency-dependent effects of extremely low-frequency electromagnetic field (ELF EMF) on Escherichia coli K-12 growth have been studied. The frequency-dependent effects of ELF EMF have shown that it can either stimulate or inhibit the growth of microbes. However, the mechanism by which the ELF EMF affects ...
Parish J A - - 2012
Five tall fescue [Lolium arundinaceum (Schreb.)] pastures: 'Kentucky-31' with 78.0% of plants infected with ergot alkaloid-producing endophyte (Neotyphodium coenophialum) (KY31 E+); 'Jesup' AR542 endophyte-infected contaminated with 30.3% tall fescue containing ergot alkaloid producing-endophyte (Jesup AR542 E+); 'GA-186' AR584 endophyte-infected contaminated with 11.8% tall fescue containing ergot alkaloid producing-endophyte (AGRFA 140); ...
Aikawa Yoshikatsu Y Laboratory of Neural Membrane Biology, Graduate School of Brain Science, Doshisha University, 1-3 Miyakodani, Kyotanabe, Kyoto 610-0394, Japan. - - 2012
The regulatory mechanism underlying the interaction of the Rabex-5 MIU domain with ubiquitinated cargos remains unclear. Rabex-5 guanine nucleotide exchange factor (GEF) mutants affected interactions of ubiquitinated cargos. GDP/GTP exchange in the GEF domain controls the MIU domain interactions with the ubiquitinated cargos. Rabex-5 GEF activity acts as an intramolecular ...
Camarero L - - 2012
Recent findings indicate that increased atmospheric deposition of nitrogen of human origin has caused changes in the pattern of ecological nutrient limitation in lakes in the northern hemisphere. An increase in the nitrogen to phosphorus ratio, and hence a shift from pristine nitrogen limitation to human-induced phosphorus limitation of phytoplankton ...
Kaspar Mathias M Center for Clinical and Research Informatics (CCRI), NorthShore University HealthSystem, Evanston, IL 60201, - - 2013
Medical visualization tools have traditionally been constrained to tethered imaging workstations or proprietary client viewers, typically part of hospital radiology systems. To improve accessibility to real-time, remote, interactive, stereoscopic visualization and to enable collaboration among multiple viewing locations, we developed an open source approach requiring only a standard web browser ...
Drutel Anne - - 2012
The thyroid is the organ with the highest selenium content per gram of tissue because it expresses specific selenoproteins. Since the discovery of myxoedematous cretinism and thyroid destruction following selenium repletion in iodine- and selenium-deficient children, data on links between thyroid metabolism and selenium have multiplied. Although very minor amounts ...
Fargier Guillaume - - 2012
The nonreceptor Syk kinase is detected in epithelial cells, where it acts as a tumor suppressor, in addition to its well-established role in immunoreceptor-based signal transduction in hematopoietic cells. Thus, several carcinomas and melanomas have subnormal concentrations of Syk. Although Syk is mainly localized at the plasma membrane, it is ...
Elam Capt Amanda L - - 2012
We report a neonate who presented at birth with multiple, scattered, white macerated plaques. Punch biopsy confirmed epidermal nevi. At 3 months of age the patient presented with infantile spasms and, after full evaluation, was diagnosed with tuberous sclerosis complex (TSC). We suggest that physicians consider TSC in a neonate with ...
Napoline J W - - 2012
A tris(phosphino)amide-ligated Zr-Co heterobimetallic complex has been shown to activate N-H bonds of hydrazine derivatives via a proton-coupled electron transfer process. Such reactivity is highly unusual for an early metal such as Zr, but is promoted by the adjacent redox active Co atom.
Benhamou Laila - - 2012
The complexation of Fe(SO(3)CF(3))(2) to the series of fluoro α-substituted tris-(2-aminomethylpyridyl)amine tripods F(1-3)TPA yields the triflato F(1-3)TPAFe(SO(3)CF(3))(2) complexes which have firstly been characterized in solution. As expected, bis-acetonitrile charged species are present in CH(3)CN, and neutral bis-triflato complexes in CH(2)Cl(2). The X-ray diffraction analyses of F(1)TPAFe(SO(3)CF(3))(2) and F(2)TPAFe(SO(3)CF(3))(2) crystallized from ...
Bell David C - - 2012
Advances in DNA sequencing, based on fluorescent microscopy, have transformed many areas of biological research. However, only relatively short molecules can be sequenced by these technologies. Dramatic improvements in genomic research will require accurate sequencing of long (>10,000 base-pairs), intact DNA molecules. Our approach directly visualizes the sequence of DNA ...
Lahijani Maryam Shams - - 2012
Effects of extremely low-frequency magnetic fields (ELF-MFs) on the histopathology, histomorphometry, ultrastructural changes (transmission electron microscope, TEM), apoptosis and alkaline phosphatase (ALP) activities in the spleens of preincubated white leghorn chicken embryo were investigated. Ninety fertilized eggs were divided into six groups as control (n = 15), sham (n = 15) and four experimental ...
Groesser L - - 2012
Epidermal nevi (EN) are classified into organoid and non-organoid subtypes.(1) The most frequent organoid EN type is the sebaceous nevus, while the keratinocytic EN represents the most common non-organoid EN. We have previously reported a peculiar EN variant termed "nevus marginatus".
Randel R D - - 2012
The influence of nutrition on puberty in beef heifers is complex and under neuroendocrine control. The stores of body fat in mammals are a determinant of the onset and maintenance of puberty. Body fat stores are greater in heifers with greater residual feed intake than in their more efficient herdmates. ...
Petherick J C - - 2012
The welfare outcomes for Bos indicus cattle (100 heifers and 50 cows) spayed by either the dropped ovary technique (DOT) or ovariectomy via flank laparotomy (FL) were compared with cattle subjected to physical restraint (C), restraint by electroimmobilization in conjunction with physical restraint (EIM), and physical restraint and mock AI ...
Börnhorst Claudia - - 2012
OBJECTIVE: Measurement errors in dietary data lead to attenuated estimates of associations between dietary exposures and health outcomes. The present study aimed to compare and evaluate different approaches of handling implausible reports by exemplary analysis of the association between dietary intakes (total energy, soft drinks, fruits/vegetables) and overweight/obesity in children. ...
Fan Jinchen - - 2012
Aramid macroscale fibers, also called Kevlar fibers, exhibit extremely high mechanical performance. Previous studies have demonstrated that bulk aramid macroscale fibers can be effectively split into aramid nanofibers (ANFs) by dissolution in dimethylsulfoxide (DMSO) in the presence of potassium hydroxide (KOH). In this paper, we first introduced the ANFs into ...
Matlis N H - - 2012
Computed tomography has profoundly impacted science, medicine and technology by using projection measurements scanned over multiple angles to permit cross-sectional imaging of an object. The application of computed tomography to moving or dynamically varying objects, however, has been limited by the temporal resolution of the technique, which is set by ...
Barnes Peter J - - 2012
Current therapy for asthma with inhaled corticosteroids and long-acting inhaled β2-agonists is highly effective, safe, and relatively inexpensive, but many patients remain poorly controlled. Most advances have been through improving these drug classes and a major developmental hurdle is to improve existing drug classes. Major unmet needs include better treatment ...
Mo Dong-Liang - - 2012
N-Vinyl nitrones derived from fluorenone have been prepared via a copper-mediated coupling between fluorenone oxime and vinyl boronic acids. These compounds undergo subsequent rearrangement and addition reactions that are distinct from the traditional [3 + 2] cycloaddition reactivity of nitrones. Thermal rearrangements of fluorenone N-vinyl nitrones give spiroisoxazolines, while treatment ...
Baroncelli Silvia - - 2012
BACKGROUND: The HIV integrase inhibitor raltegravir (RAL) can exacerbate autoimmune diseases in genetically predisposed mice. To evaluate whether this may occur in clinical practice, we clinically monitored HIV positive patients treated with RAL and measured a panel of autoantibodies (auto-Abs) during the first year of RAL treatment. METHODS: This was ...
Gillmeister Helge - - 2012
In an endogenous cueing paradigm with central visual cues, observers made speeded responses to tactile targets at the hands, which were either close together or far apart, and holding either two separate objects or one common object between them. When the hands were far apart, the response time costs associated ...
Borges J P G - - 2012
Background and Objectives  Platelet transfusions are performed almost entirely according to expert experience. This study assessed the effectiveness of a restrictive guideline to reduce platelet transfusions in preterm infants. Methods  A retrospective cohort of preterm infants with a birth weight of <1500 g had been born in 2 periods. In Period ...
Zhang Jianwen - - 2012
Urachal carcinoma (UrC) is a rare but highly malignant epithelial cancer and commonly found in the urachal remnant which connects the dome of the bladder to the umbilicus via the ligamentum commune. Because of the specificity of the tumor location and its rarity, the diagnosis of UrC is often difficult. ...
Jordan Shawn N SN Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, - - 2012
Rho GTPases are molecular switches that elicit distinct effects on the actomyosin cytoskeleton to accurately promote cytokinesis. Although they represent less than 1% of the human genome, Rho GTPases exert disproportionate control over cell division. Crucial to this master regulatory role is their localized occupation of specific domains of the ...
Del Re A C - - 2012
Abstract Mindfulness-Based Stress Reduction (MBSR) is an experientially based group intervention empirically supported to reduce psychological symptomology. Although MBSR has shown to be an effective intervention, little is known about which facets of the intervention are important in producing positive outcomes. This study tested several aspects of mindfulness practice (total ...
Haase R - - 2012
In adult cancer patients the negative predictive value of elevated CRP levels has been described for several malignancies. Only few studies have analyzed the prognostic role of CRP in children and adolescents with classical HL. In these studies elevated CRP levels correlate with the presence of classical risk factors and ...
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