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Jastrzebski Marek - - 2012
AIMS: To investigate the effect of implantation-related characteristics, especially lead position and left ventricular (LV)-paced QRS morphology, on long-term mortality and morbidity in cardiac resynchronization therapy (CRT) patients.METHODS AND RESULTS: The study retrospectively analysed 362 consecutive patients who underwent CRT device implantation over a 6 year period. Pre-implantation, LV-only paced, ...
Zhao Yuefang - - 2012
Acetohydroxyacid synthase (AHAS), which catalyzes the first step in the biosynthesis of branched-chain amino acids, is composed of catalytic and regulatory subunits. The enzyme exhibits full activity only when the regulatory subunit (RSU) binds to the catalytic subunit (CSU). However, the crystal structure of the holoenzyme has not been reported ...
Kubo Tomohiro T Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, - - 2012
The tpg1 mutant of Chlamydomonas lacks the tubulin polyglutamylase TTLL9 and is deficient in flagellar tubulin polyglutamylation. It exhibits slow swimming, whereas the double mutant with oda2 (a slow-swimming mutant that lacks outer-arm dynein) is completely nonmotile. Thus, tubulin polyglutamylation must be important for the functioning of inner-arm dynein(s). In ...
He Huiying - - 2012
Study Type - Diagnosis (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? High grade prostatic intraepithelial neoplasia is a pre-malignant lesion to prostate cancer and is associated with 20%-25% risk of prostate cancer in subsequent repeat biopsies. ERG is a highly prostate-cancer-specific marker. ...
Luo Yanfei - - 2012
The objective of the present study was to develop stable pellets-layered Simvastatin (SIM) nanosuspensions with improved dissolution and bioavailability. The nanosuspensions were prepared with 7% HPMC, antioxidant 0.03% butylated hydroxyanisole and 0.2% citric acid (m/v) by low temperature grinding. After that, SDS with SIM was in a ratio of 1:5 ...
Kievit Paul P Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Portland, Oregon, - - 2013
The melanocortin-4 receptor (MC4R) is well recognized as an important mediator of body weight homeostasis. Activation of MC4R causes dramatic weight loss in rodent models, and mutations in human are associated with obesity. This makes MC4R a logical target for pharmacological therapy for the treatment of obesity. However, previous studies ...
Wang Hong - - 2012
Opportunistic pathogens represent a unique challenge because they establish and grow within drinking water systems, yet the factors stimulating their proliferation are largely unknown. The purpose of this study was to examine the influence of pipe materials, disinfectant type and water age on occurrence and persistence of three opportunistic pathogens ...
Chan Soeung Sann - - 2012
BACKGROUND An international review of the Cambodian Expanded Programme on Immunization (EPI) in 2010 and other data show that despite immunization coverage increases and vaccine preventable diseases incidence reductions, inequities in access to immunization services exist. Utilizing immunization and health systems literature, analysis of global health databases and the EPI ...
Saudino Kimberly J KJ Psychology Department, Boston University, Boston, MA, USA. - - 2013
The Boston University Twin Project (BUTP) is a multi-method, multi-situation, longitudinal study of early child temperament and related behaviors. The first phase of this project focused primarily on activity level and comprised over 300 twin pairs assessed in the home and lab at ages 2 and 3. Subject recruitment, sample ...
Hostinar Camelia E - - 2012
Executive function (EF) abilities are increasingly recognized as an important protective factor for children experiencing adversity, promoting better stress and emotion regulation as well as social and academic adjustment. We provide evidence that early life adversity is associated with significant reductions in EF performance on a developmentally sensitive battery of ...
Taylor D Robin - - 2012
Asthma is a heterogeneous disease, with wide variability in pathology, natural history, and response to therapy. Historically, treatment of asthma relied almost exclusively on clinical judgment and pulmonary function tests (spirometry or peak flows), despite the limitations of both. Physiological tests are one step removed from what the clinician needs ...
Khan Sadia Afrin - - 2012
This communication reports, for the first time, the design of distance dependent SERS assay for monitoring the photothermal antibacterial activity process.
Deneke Christoph - - 2012
Freestanding, edge-supported silicon nanomembranes are defined by selective underetching of patterned silicon-on-insulator substrates. The membranes are afterwards introduced into a molecular beam epitaxy chamber and overgrown with InAs, resulting in the formation of InAs islands on flat areas and at the top of the Si nanomembranes. A detailed analysis of ...
Woodward Alistair - - 2012
About a third of the world's population is exposed to secondhand smoke (SHS), despite reductions in smoking prevalence in many countries. Accurate, cost-effective measures of exposure are needed in investigations of the health risks associated with SHS, and in studies of interventions to extend smoke-free environments. There have been important ...
Axelson Hans W - - 2012
Purpose: Recovery is limited following traumatic brain injury (TBI) since injured axons regenerate poorly and replacement of lost cells is minimal. Behavioral improvements could instead be due to plasticity of uninjured brain regions. We hypothesized that plasticity of the uninjured hemisphere occurs contralateral to a focal TBI in the adult ...
Simond Mickaël R - - 2012
A classical force field is proposed for the molecular simulation of primary alkanolamines containing a NH(2) CCOH backbone. A method is devised to take into account the polar (H-bonding) environment of the alkanolamines by calculating electrostatic charges in the presence of explicit solvent molecules. The force field does not use ...
Scholtysek Peggy - - 2012
Semitelechelic poly(glycerol methacrylate)s having a perfluoroalkyl endgroup (PGMAn-F9) were synthesized by ATRP. The interactions of these polymers with different degrees of polymerization with chiral or racemic dipalmitoylphosphatidylcholine (L-DPPC, D-DPPC or rac-DPPC) monolayers at the air/water interface were studied. Langmuir trough measurements coupled with epi-fluorescence microscopy allowed for the observation of ...
Yu Q - - 2012
Lolium rigidum is an obligately cross-pollinated, genetically diverse species and an economically important, herbicide resistance-prone weed. Our previous work has demonstrated that recurrent selection of initially susceptible L. rigidum populations with low herbicide rates results in rapid herbicide resistance evolution. Here we report on the mechanisms endowing low-dose-selected diclofop-methyl resistance ...
Hilbrands A M - - 2012
Two experiments were conducted to evaluate the effects of feeding continuously a diet containing 40% dried distillers grains with solubles (DDGS) or intermittently diets containing 20 or 40% DDGS on growth performance and carcass quality of pigs. Pigs' responses to abrupt introduction and removal of dietary DDGS with differing concentrations ...
Corazzin M - - 2012
The objective of this trial was to determine the effect of breed and long-term dietary linseed addition on composition of fatty acids and expression of some genes involved in the lipid metabolism within s.c. adipose tissue of young bulls. Italian Simmental and Holstein bulls (n = 16/breed) were fed a ...
Khafizov Kamil - - 2012
Sodium-coupled substrate transport plays a central role in many biological processes. However, despite knowledge of the structures of several sodium-coupled transporters, the location of the sodium-binding site(s) often remains unclear. Several of these structures have the five transmembrane-helix inverted-topology repeat, LeuT-like (FIRL) fold, whose pseudosymmetry has been proposed to facilitate ...
Forteza Rosanna Malbran RM Division of Pulmonary Critical Care, Sleep and Allergy Medicine, University of Miami Miller School of Medicine, Miami, Florida 33136, - - 2012
Cigarette smoke (CigS) exposure is associated with increased bronchial epithelial permeability and impaired barrier function. Primary cultures of normal human bronchial epithelial cells exposed to CigS exhibit decreased E-cadherin expression and reduced transepithelial electrical resistance. These effects were mediated by hyaluronan (HA) because inhibition of its synthesis with 4-methylumbelliferone prevented ...
Guichet Pierre-Olivier - - 2012
Glioblastoma multiform (GBM) are devastating brain tumors containing a fraction of multipotent stem-like cells which are highly tumorigenic. These cells are resistant to treatments and are likely to be responsible for tumor recurrence. One approach to eliminate GBM stem-like cells would be to force their terminal differentiation. During development, neurons ...
Zheng Yi - - 2012
Two types of grape pomace were ensiled with eight strains of lactic acid bacteria (LAB). Both fresh grape pomace (FrGP) and fermented grape pomace (FeGP) were preserved through alcoholic fermentation but not malolactic conversion. Water leaching prior to storage was used to reduce water soluble carbohydrates and ethanol from FrGP ...
Azar Rima R Psychobiology of Stress & Health Lab, Psychology Department, Mount Allison University, Sackville, New Brunswick, Canada. - - 2013
We examined depressive symptoms, C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels during early to-midgestation. We measured depressive symptoms on the Patient Health Questionnaire-9 (PHQ-9), and serum CRP, IL-6, and TNF-α levels twice in 27 pregnant women. After adjustment, depressive symptoms prospectively (β=0.42, p<0.05 at 16-20 weeks ...
Fennouri Aziz - - 2012
Glycosaminoglycans are biologically active anionic carbohydrates that are among the most challenging biopolymers with regards to their structural analysis and functional assessment. The potential of newly introduced biosensors using protein nanopores that have been mainly described for nucleic acids and protein analysis to date, has been here applied to this ...
Haq Nazia - - 2012
Abstract Gap junctions (GJs) are intercellular channels which are composed of the connexin family of proteins that allow electrical and chemical communications and synchronization in tissue ensembles. Evidence suggests that pharmaceutical modulators of these channels may have therapeutic potential or carry undesired liability. In this report, we exogenously expressed human ...
Pearce Karma L - - 2012
Abstract Background: Type 2 diabetes is associated with reductions in cognitive function that are associated with glycated hemoglobin (HbA1c) levels, but there is no information on whether cognition is related to postmeal glucose spikes. We explored the relationship of cognition to glucose levels measured by a continuous glucose monitoring system ...
Stump John L - - 2012
Abstract Objectives: The objective of this case study was to use integrative medicine to treat a debilitating and long-standing case of blepharospasm. Subject: The patient suffered from blepharospasm, which conventional medicine had failed to alleviate despite numerous and varied attempts over the course of 3 years of treatment. Blepharospasm involves ...
Jungraithmayr Wolfgang - - 2012
Purpose:To test the in vivo feasibility of magnetic resonance (MR) imaging of ischemia reperfusion injury after syngeneic lung transplantation in mice and to characterize tissue relaxation properties by using very short echo-time (TE) sequences at 4.7 T.Materials and Methods:The experimental protocol was approved by the institutional animal committee. MR imaging ...
Deonandan Raywat - - 2012
Reproductive medical tourism is by some accounts a multibillion dollar industry globally. The seeking by clients in high income nations of surrogate mothers in low income nations, particularly India, presents a set of largely unexamined ethical challenges. In this paper, eight such challenges are elucidated to spur discussion and eventual ...
Hansson Emma C - - 2012
OBJECTIVE: To assess the prevalence, indications and appropriateness of antiplatelet therapy in patients operated for acute aortic dissection and its associations with bleeding complications and mortality. DESIGN: A retrospective single-centre study comparing patients with and without ongoing antiplatelet therapy. SETTING: University Hospital in Western Sweden. PATIENTS: 133 consecutive patients operated ...
Mansell Stephen M - - 2012
Trimethylsilylphosphaalkyne binds readily to a variety of transition metals. Binding can take place using either the end-on or side-on mode and to either mononuclear or multinuclear metal complexes. The synthesis, structure and characterisation of eight such complexes, [Cp(2)Zr(PMe(3))(Me(3)SiC[triple bond, length as m-dash]P)], [(C(6)F(5))(2)FB(C(6)F(4))PCSiMe(3))ZrCp(2)(PMe(3))], [(C(6)F(5))(2)XB(C(6)F(4))(ZrCp(2))(2)P(2)(CSiMe(3))(2)] (X = F/H), [(Me(3)Si-C[triple bond, length ...
Shi Jing - - 2012
Five new coumarin glycosides, umbelliferone 7-O-sophoroside (1), umbelliferone 7-O-β-D-glucopyranosyl(1 → 3)-β-D-glucopyranoside (2), umbelliferone 7-O-β-D-glucopyranosyl(1 → 3)-[β-D-apiofuranosyl(1 → 6)]-β-D-glucopyranoside (3), umbelliferone 7-O-β-D-glucopyranosyl(1 → 2)-β-D-apiofuranosyl(1 → 6)-β-D-glucopyranoside (4), and umbelliferone 7-O-β-D-glucopyranosyl(1 → 5)-β-D-apiofuranosyl(1 → 6)-β-D-glucopyranoside (5), and two new iridoid glucosides, 7-O-E-isoferuloyl loganic acid (6) and 7-O-β-D-glucopyranosyl loganin (7), together with eight known compounds (8-15) were isolated from the stems of Hydrangea paniculata. Their structures were ...
Ahola Niina - - 2012
There is an increasing need for synthetic bone substitute materials that decrease the need for allografts and autografts. In this study, composites of β-tricalcium phosphate and a biodegradable poly(L-lactide-co-ε-caprolactone) were manufactured using extrusion to form biodegradable composites with high β-tricalcium phosphate contents for osteoconductivity. The hydrolytic degradation of the composites ...
Martirosyan Varsik - - 2012
The aim of the present work was to investigate the frequency-dependent effects of mechanical vibration at infrasound frequency (MV at IS frequency or MV) on E. coli K-12 growth by investigating the cell proliferation, using radioactive [(3)H]-thymidine assay. The frequency-dependent effects of MV were shown that it could either stimulate ...
Rochester Johanna R JR Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA. - - 2012
The continued presence of gonadotropin-releasing hormone (GnRH) neurons is required for a healthy reproductive lifespan, but factors that maintain postnatal GnRH neurons have not been identified. To begin to understand these factors, we investigated whether 1) fibroblast growth factor (FGF) signaling and 2) interactions with the opposite sex are involved ...
Armistead-Jehle Patrick - - 2012
The study examined Symptom Validity Test (SVT) performance in a sample of military service members on active orders as a function of evaluation context. Service members were assessed in the context of either a pending disability evaluation (Medical Evaluation Board; MEB) or a non-MEB/clinical evaluation. Overall, 41.8% of the sample ...
Carll Alex P AP Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, - - 2013
Acute air pollutant inhalation is linked to adverse cardiac events and death, and hospitalizations for heart failure. Diesel engine exhaust (DE) is a major air pollutant suspected to exacerbate preexisting cardiac conditions, in part, through autonomic and electrophysiologic disturbance of normal cardiac function. To explore this putative mechanism, we examined ...
Hach Faraz F School of Computing Science, Simon Fraser University, Burnaby, Canada, V5A 1S6. - - 2012
The high throughput sequencing (HTS) platforms generate unprecedented amounts of data that introduce challenges for the computational infrastructure. Data management, storage and analysis have become major logistical obstacles for those adopting the new platforms. The requirement for large investment for this purpose almost signalled the end of the Sequence Read ...
Ma Da - - 2012
Be My Guest: Two acyclic cucurbit[n]uril-type receptors that carry SO(3) (-) -groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block ...
Chi Celestine N - - 2012
The PDZ domain is a protein-protein interaction module with a shallow binding groove where protein ligands bind. However, interactions that are not part of this canonical binding groove are likely to modulate peptide binding. We have investigated such interactions beyond the binding groove for PDZ3 from PSD-95 and a peptide ...
Phillips P S - - 2012
Aim: To assess the clinical and radiological characteristics of the posterior prolongation of the cartilaginous nasal septum, an under-utilised source of autologous cartilage for nasal reconstruction. Materials and methods: Consecutive patients undergoing primary, external approach rhinoplasty were included. The septal cartilage was assessed intra-operatively prior to routine harvest. Cartilage use ...
Batura Deepak D Department of Urology, Northwick Park Hospital, Watford Road, London HA1 3UJ, UK. - - 2013
Transrectal ultrasound-guided needle biopsies (TGBs) are the mainstay of prostate cancer diagnosis. An average of 72,500 TGBs were performed in England and Wales in 2008. Current guidelines recommend fluoroquinolone prophylaxis for TGBs. However, emerging fluoroquinolone resistance has led to increased frequency and morbidity due to post-TGB infections. Following TGB, 2.15%-3.6% ...
Kong Chee Hoe CH Department of Cardiac, Thoracic and Vascular Surgery, National University Heart Centre, - - 2013
Extracellular matrix (ECM) remodelling of the vessel wall is hypothesized to be an important step in atherosclerosis. Changes of the ECM are associated with the gradual progression of an atherosclerotic lesion from a lipid streak to complicated unstable plaque, leading to a complete vessel occlusion and eventually myocardial infarction (MI). ...
Bartz M - - 2012
Fatty acid composition in porcine intramuscular fat affects the dietetic value and technological properties of meat. The stearoyl-CoA desaturase (SCD) gene is a strong positional and functional candidate for fatty acid composition. Our sequence analysis in 4 breeds (Duroc, Pietrain, Polish Landrace, and Polish Large White) revealed a novel single-nucleotide ...
Agudelo Carlos A - - 2012
Magnetic resonance imaging is one of the most important fields for cellular imaging due to its non-invasive capacity, spatial resolution, and sensibility to visualized transplanted cells. An enhanced magnetic resonance image can be achieved by using contrast agents containing paramagnetic gadolinium chelates, which have the widest clinical use. To obtain ...
Brambillasca Silvia S Molecular Diabetology, Paul Langerhans Institute Dresden, Uniklinikum Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, - - 2012
Genome-wide association studies have led to the identification of numerous susceptibility genes for type 2 diabetes. Among them is Cdkal1, which is associated with reduced β-cell function and insulin release. Recently, CDKAL1 has been shown to be a methylthiotransferase that modifies tRNA(Lys) to enhance translational fidelity of transcripts, including the ...
Zhao Yao - - 2012
Two photons are better than one: A square-planar Pt(II) complex with derivatized pyridine ligands was synthesized, which undergoes two-photon-induced ligand substitution with 600-740 nm light. Linear and quadratic density functional response theory allowed identification of the electronic transitions involved.
Beh Maia M - - 2012
The first wildfires in sudden oak death-impacted forests occurred in 2008 in the Big Sur region of California, creating the rare opportunity to study the interaction between an invasive forest pathogen and a historically recurring disturbance. To determine whether and how the sudden oak death pathogen, Phytophthora ramorum, survived the ...
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