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Gábriel Robert R Department of Experimental Zoology and Neurobiology, University of Pécs, H-7621, Pécs, Hungary. - - 2013
Diabetic retinopathy, a common complication of diabetes, develops in 75% of patients with type 1 and 50% of patients with type 2 diabetes, progressing to legal blindness in about 5%. In the recent years, considerable efforts have been put into finding treatments for this condition. It has been discovered that peptidergic mechanisms ...
van Hartingsveldt Bart B Immunology Translational Medicine, Janssen Research & Development, LLC, Spring House, PA 19477, - - 2013
To assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of CNTO 5825 following single-dose intravenous (i.v.) and subcutaneous (s.c.) administration in healthy and healthy atopic subjects. Sixty-four subjects received a single dose of placebo or CNTO 5825 (0.1, 0.3, 1.0, 3.0, or 10 mg kg(-1) i.v. in a dose-escalating manner, ...
Pottegård Anton A Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, DK-5000, Odense C, Denmark. - - 2013
Studies of the carcinogenic potential of benzodiazepines and related drugs (BZRD) have been equivocal. A recent study reported a 35% excess cancer risk among users of hypnotics, including benzodiazepines. Using Danish nationwide registers, we conducted a matched case-control study of the association between BZRD and cancer risk. During 1 January ...
Celik Deniz D Faculty of Medicine, Department of Chest Diseases, Gaziosmanpasa University, Tokat, - - 2013
Cysteinyl leukotrienes (CysLTs) are among important inflammatory mediators in asthma pathogenesis. In this study, we aimed to determine leukotriene D₄ (LTD₄) and leukotriene E₄ (LTE₄) levels in exhaled breath condensate (EBC) in asthmatics and to evaluate the effect of smoking upon CysLTs levels and to speculate the importance of adding ...
Lillegraven Siri S Brigham and Women's Hospital, Boston, Massachusetts; Diakonhjemmet Hospital, Oslo, Norway. - - 2013
Matrix-based risk models have been proposed as a tool to predict rapid radiographic progression (RRP) in rheumatoid arthritis (RA), but the experience with such models is limited. We tested the performance of 3 risk models for RRP in an observational cohort. Subjects from an observational RA cohort with hand radiographs ...
Farrokhi Shawn S Department of Physical Therapy,University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA. - - 2013
To evaluate the association between severity of coexisting patellofemoral (PF) disease with lower extremity impairments and functional limitations in patients with tibiofemoral (TF) osteoarthritis (OA). Radiographic views of the TF and PF compartments, knee extension strength, and knee range of motion were obtained for 167 patients with knee OA. Additionally, ...
Jastrzebski Sandra S Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030-5456, - - 2013
We examined the effects that ovariectomy had on sclerostin mRNA and protein levels in the bones of 8-week-old mice that were either sham-operated (SHAM) or ovariectomized (OVX) and then euthanized 3 or 6 weeks later. In this model, bone loss occurred between 3 and 5 weeks postsurgery. In calvaria, ovariectomy ...
Lacruz Rodrigo S RS Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, CA 90605, - - 2013
Molecular events defining enamel matrix removal during amelogenesis are poorly understood. Early reports have suggested that adaptor proteins (AP) participate in ameloblast-mediated endocytosis. Enamel formation involves the secretory and maturation stages, with an increase in resorptive function during the latter. Here, using real-time PCR, we show that the expression of ...
Neale Chris C Centre for Human Psychopharmacology, Swinburne University, Melbourne, Vic. 3122, - - 2013
Over recent years there has been increasing research into both pharmaceutical and nutraceutical cognition enhancers. Here we aimed to calculate the effect sizes of positive cognitive effect of the pharmaceutical modafinil in order to benchmark the effect of two widely used nutraceuticals Ginseng and Bacopa (which have consistent acute and ...
Giannopoulos Panagiotis P Specialist Community Addictions Service, Unit 5, The Valley Centre, Gordon Road High Wycombe, Buckinghamshire, HP13 6EQ, UK. - - 2013
Hippocampus-dependent memory involves the activity of sharp wave ripples (SWRs), which are thought to participate in the process of memory consolidation. The hippocampus contains high levels of endogenous opioids and of μ-opioid receptors (MORs). Here, we have assessed the role of MOR agonists in the modulation of SWRs. Using recordings ...
Lee N J NJ College of Pharmacy, Chungbuk National University, Chungbuk, South - - 2013
The effects of 4-O-methylhonokiol (MH), a constituent of Magnolia officinalis, were investigated on human prostate cancer cells and its mechanism of action elucidated. The anti-cancer effects of MH were examined in prostate cancer and normal cells. The effects were validated in vivo using a mouse xenograft model. MH increased the ...
Tsampalieros Anne A Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, - - 2013
The impact of glucocorticoids (GC) on skeletal development has not been established. The objective of this study was to examine changes in volumetric bone mineral density (vBMD) and cortical structure over 1 year in childhood nephrotic syndrome (NS) and to identify associations with concurrent GC exposure and growth. Fifty-six NS ...
Su Nan N Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, - - 2013
H1 calponin (CNN1) is known as a smooth muscle-specific, actin-binding protein which regulates smooth muscle contractive activity. Although previous studies have shown that CNN1 has effect on bone, the mechanism is not well defined. To investigate the role of CNN1 in maintaining bone homeostasis, we generated transgenic mice overexpressing Cnn1 ...
Ahrar Siavash S Department of Biomedical Engineering, University of California, Irvine, CA 92697-2715, - - 2013
Microfluidic technology is emerging as a useful tool for the study of brain slices, offering precise delivery of chemical factors along with robust oxygen and nutrient transport. However, continued reliance upon electrode-based physiological recording poses inherent limitations in terms of physical access, as well as the number of sites that ...
Hara Seigo - - 2013
The aim of this study was to investigate the additive effect of the active form of vitamin D3 on the gain in back extensor strength through a back extensor exercise. A total of 107 postmenopausal women with osteoporosis were randomly divided into two groups: the D3 group and the control ...
Shortall S E SE School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, - - 2013
Recreational users report that mephedrone has similar psychoactive effects to 3,4-methylenedioxymethamphetamine (MDMA). MDMA induces well-characterized changes in body temperature due to complex monoaminergic effects on central thermoregulation, peripheral blood flow and thermogenesis, but there are little preclinical data on the acute effects of mephedrone or other synthetic cathinones. The acute ...
Wasko Mary Chester M MC West Penn Allegheny Health System, Allegheny Singer Research Institute, 4800 Friendship Avenue, North Tower, Suite 2600, Pittsburgh, PA 15224, USA. - - 2013
While medications used to treat rheumatoid arthritis (RA) may affect survival in RA, few studies take into account the propensity for medication use, which may reflect selection bias in treatment allocation in survival models. We undertook this study to examine the relationship between methotrexate (MTX) use and mortality in RA, ...
Cottrell G S GS Reading School of Pharmacy, University of Reading, Reading, UK. - - 2013
The enzymatic activity of peptidases must be tightly regulated to prevent uncontrolled hydrolysis of peptide bonds, which could have devastating effects on biological systems. Peptidases are often generated as inactive propeptidases, secreted with endogenous inhibitors, or they are compartmentalized. Propeptidases become active after proteolytic removal of N-terminal activation peptides by ...
Burdet Juliana J Laboratorio de Fisiopatogenia, Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, - - 2013
Infections with a strain of Escherichia coli producing Shiga toxins could be one of the causes of fetal morbidity and mortality in pregnant women. We have previously reported that Shiga toxin type 2 (Stx2) induces preterm delivery in pregnant rats. In this study, we evaluate the role of TNF-α, PGs ...
Jeemon Panniyammakal P Centre for Chronic Disease Control, New Delhi, - - 2013
UA (uric acid) is the final product of purine metabolism in humans and is implicated in many disease conditions. Sustained hyperuricaemia has putative adverse roles in cardiovascular diseases. Despite strong evidence emerging from large epidemiological studies supporting the hypothesis that UA independently influences cardiovascular disease outcomes and mortality, a causal ...
Shafie Nur Aliaa - - 2013
An investigative study was carried out in Langat River to determine the heavy metal pollution in the sediment with 22 sampling stations selected for the collection of sediment samples. The sediment samples were digested and analyzed for extractable metal ((48)Cd, (29)Cu, (30)Zn, (33)As, (82)Pb) using the Inductively Coupled Plasma-Mass Spectrometry ...
Carro Perez Magali E - - 2013
This article proposes an alternative to increase the reliability and reproducibility of a colorimetric method to measure arsenic (As) concentrations. The method of analysis developed incorporates a digital analysis technique to eliminate the operator dependence of results, and As concentrations are quantitatively determined from digital levels computed from photographs of ...
Samide Adriana - - 2013
A pharmaceutical product, Trimethoprim (TMP), IUPAC name: 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine was investigated, as inhibitor to prevent carbon steel corrosion in acidic environments. The study was performed using weight loss and electrochemical measurements, in temperatures ranging between 25-55°C. The surface morphology before and after corrosion of carbon steel in 1.0 M HCl solution in ...
Lee Jae Hoon - - 2013
The objectives of this study were to identify multi-level stressors at the DNA/biochemical level to the community level in fish in an urban stream and to develop an integrative health response (IHR) model for ecological health diagnosis. A pristine control site (S (c) ) and an impacted site (S (i) ...
Shanableh Abdallah M - - 2013
This study was part of a larger effort that involves evaluating alternatives to upgrading secondary treatment systems in the United Arab Emirates for the removal of nutrients. In this study, six modified bentonite (BNT) phosphate adsorbents were prepared using solutions that contained hydroxy-polycations of aluminum (Al-BNT), iron (Fe-BNT), and mixtures ...
Zhao Gaofeng - - 2013
This study was conducted to investigate the current contamination status of polyhalogenated aromatic hydrocarbons (PHAHs) in sediments from the mainstream and 22 primary tributaries of the Yangtze River in the Three Gorges Reservoir region. To accomplish this, the concentrations of 22 polybrominated biphenyl (PBB) congeners, 27 polybrominated diphenyl ether (PBDE) ...
Duarte Katia - - 2013
This study attempts a treatment strategy of a bleached kraft pulp mill effluent with Rhizopus oryzae or Pleurotus sajor caju encapsulated on silica-alginate (biocomposite of silica-alginate-fungi, with the purpose of reducing its potential impact in the environment. Active (alive) or inactive (death by sterilization) Rhizopus oryzae or Pleurotus sajor caju ...
Kolon Krzysztof - - 2013
In this investigation we focus on the concentration of elements in Viscum album and its host (Sorbus aucuparia) as bioindicators of urban pollution. These broadly widespread species, very common in polluted areas may provide important information to monitor environmental quality throughout the year, especially for V. album. Cd, Co, Cr, ...
Jeng Hueiwang Anna - - 2013
A cross-sectional study was conducted to assess whether urinary 1-hydroxypyrene (1-OHP) could serve as a biomarker to assess the effect of PAHs on cellular and molecular changes of sperm. Urine and semen samples were collected from a total of 65 healthy coke oven workers. Sperm quality parameters (concentration, motility, vitality, ...
Ribeiro Elaine N - - 2013
The present study evaluated the toxic potential and physicochemical characteristics of waste water generated in nitrocellulose production, including effluents from delignification, bleaching, nitration and mixture (composed of these three effluents), from a plant in the Paraiba Valley, São Paulo, Brazil. The test organisms used for toxicity assays were Daphnia similis, ...
Gellrich Vanessa - - 2013
The aims of the present study were to determine PFAS (perfluoroalkyl and polyfluoroalkyl substances) concentrations in various sources of water intended for human consumption, use these data to calculate the possible uptake via water as well as to estimate the water related health risk to consumers. A total of 177 ...
Chen Shou-Tung - - 2013
The objectives of this investigation were to examine whether airborne particles induce DNA damaging and estrogen-disrupting effects and to explore the relationships between them. In this study, airborne particulate was collected at an urban, a suburban, and a rural site in central Taiwan. The organic solvent extracts of airborne particulate ...
Chamorro Soledad - - 2013
Aryl Hydrocarbon Receptor (AhR) ligands also known as dioxin-like compounds, constitute a substantial part of the total toxicity from many pollution sources, including pulp mill effluents. The aim of this article was to evaluate dioxin-like activity in different kraft mill effluents by a combination of yeast bioassays and gas chromatography-mass ...
Petchey William G - - 2013
To assess the impact of vitamin D supplementation (cholecalciferol) on the insulin sensitivity and metabolic health of patients with chronic kidney disease (CKD). Twenty-eight adult patients with CKD stages 3-4 were recruited from the outpatient department of the Princess Alexandra Hospital (Brisbane, Australia) to a double-blind randomized trial of cholecalciferol ...
Maly Monica R MR Institute for Applied Health Sciences, Hamilton, Ontario, Canada. - - 2013
To determine the extent to which thigh intermuscular fat (IMF) and quadriceps muscle (QM) volumes explained variance in knee extensor strength and physical performance in women with radiographic knee osteoarthritis (ROA) and without. Baseline data from 125 women (age ≥50 years) in the Osteoarthritis Initiative study, with or at risk ...
Drouin Elise E EE Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. - - 2013
Autoantigen presentation by HLA-DR molecules is thought to be a central component of many autoimmune diseases, but identifying disease-relevant autoantigens has been a difficult challenge. In this study we aimed to identify autoantigens in patients with antibiotic-refractory Lyme arthritis, in which infection-induced autoimmunity is thought to play an important role. ...
Li Nan N Department of Head and Neck Surgery, The M.D. Anderson Cancer Center, Houston, Texas 77030, - - 2013
In the past 3 decades, the incidence of thyroid cancer in the United States has been increasing. There has been debate on whether the increase is real or an artifact of improved diagnostic scrutiny. Our hypothesis is that both improved detection and a real increase have contributed to the increase. ...
Pickhardt Perry J PJ Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792–3252, USA. - - 2013
Computed tomography colonography (CTC) continues to mature and evolve as a noninvasive imaging test of the large intestine. The aim of this review is to provide an update on the recent and emerging data that further supports the clinical effectiveness of CTC. The diagnostic performance of CTC for detecting colorectal ...
Desai Sonali P SP Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. - - 2013
Pneumococcal vaccination is important for patients taking immunosuppressive medications, but prior studies suggest that most patients do not undergo vaccination. The aim of this study was to evaluate the effects of a point-of-care paper reminder form as a quality improvement (QI) strategy to increase the numbers of immunosuppressed patients being ...
Gannagé-Yared Marie-Hélène - - 2013
Heterozygous mutations in the IGF1 receptor (IGF1R) gene lead to partial resistance to IGF1 and contribute to intrauterine growth retardation (IUGR) with postnatal growth failure. To date, homozygous mutations of this receptor have not been described. A 13.5-year-old girl born from healthy first-cousin parents presented with severe IUGR and persistent ...
Martini Joerg J Palo Alto Research Center, 3333 Coyote Hill Rd., Palo Alto, CA 94304, USA. - - 2012
We describe an optical detection technique that delivers high signal-to-noise discrimination to enable a multi-parameter flow cytometer that combines high performance, robustness, compactness and low cost. The enabling technique is termed "spatially modulated detection" and generates a time-dependent signal as a continuously fluorescing (bio-) particle traverses an optical transmission pattern ...
Hadoush Hikmat H Graduate School of Health Sciences, Hiroshima University, Hiroshima, - - 2012
We quantified and compared neuroimaging data and behavioral data (cortical plasticity and hand sensibility, respectively) from a patient who underwent toe-to-index transplantation. Magnetoencephalographic (MEG) recordings of somatosensory-evoked fields (SEFs) response to mechanical tactile stimulation of the index and little fingers of both hands were obtained in parallel with a hand ...
Yılmaz Sevdan - - 2012
Abstract This study was conducted to investigate the effects of garlic and ginger oils on hematological and biochemical health characteristics of sea bass Dicentrarchus labrax. Fish were exposed to garlic oil (0.01 or 0.02 mL/L), ginger oil (0.01 or 0.02 mL/L), or a combination of the two oils (each oil at a ...
Wojciechowski David - - 2012
In June 2011 the US Food and Drug Administration approved belatacept (Nulojix; Bristol-Myers Squibb, Princeton, New Jersey, USA) for the prophylaxis of organ rejection in adult kidney transplant recipients. This review will discuss the use of belatacept for the prevention of acute rejection as part of a maintenance immunosuppression regimen. ...
Shakya Holly B - - 2012
To evaluate the relationship between the parenting style of an adolescent's peers' parents and an adolescent's substance use. Longitudinal survey. Adolescents across the United States were interviewed at school and at home. Nationally representative sample of adolescents in the United States. Authoritative vs neglectful parenting style of adolescent's parents and ...
Ernst Carl - - 2012
CONTEXT Brain-derived neurotrophic factor (BDNF) is suspected of being a causative factor in psychiatric disorders based on case reports or studies involving large structural anomalies. OBJECTIVE To determine the involvement of BDNF in human psychopathology. DESIGN Case-control study. SETTING Microarray-based comparative genomic hybridization data from 7 molecular diagnostic centers including ...
Osypuk Theresa L - - 2012
CONTEXT Extensive observational evidence indicates that youth in high-poverty neighborhoods exhibit poor mental health, although not all children may be affected similarly. OBJECTIVE To use experimental evidence to assess whether gender and family health problems modify the mental health effects of moving from high- to low-poverty neighborhoods. DESIGN Randomized controlled ...
Dumond Julie B JB UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 27599-7569, USA. - - 2012
A previously published study of antiretroviral pharmacokinetics in the female genital tract of HIV-infected women demonstrated differing degrees of female genital tract penetration among antiretrovirals. These blood plasma (BP) and cervicovaginal fluid (CVF) data were co-modelled for four antiretrovirals with varying CVF exposures. Six paired BP and CVF samples were ...
Li Jun-Xu JX Departments of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, - - 2012
The cannabinoid receptor agonist Δ(9)-tetrahydrocannabinol (THC) enhances the antinociceptive effects of µ-opioid receptor agonists, raising the possibility of using a combination of THC and opioids for treating pain. This study examined the effects of noncontingent and contingent administration of THC on intravenous heroin self-administration in rhesus monkeys. Self-administration of different ...
Pearson-Fuhrhop Kristin M KM Department of Anatomy and Neurobiology, University of California, Irvine, Orange, California, - - 2012
The fields of clinical genetics and pharmacogenetics are rapidly expanding. Genetic factors have numerous associations with injury and with treatment effects in the setting of neural plasticity and recovery. Evidence is reviewed that established genetic variants, as well as some more recently described variants, are related to outcome after neural ...
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