Search Results
Results 401 - 450 of 2040
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Gomez Francisco L Guerra - - 2012
In the conventional synthesis of 1,4,7-tris-(glutaric acid)-1,4,7-triazacyclononane (NOTGA), four isomeric species are usually generated by the alkylation of 1,4,7-triazacyclononane with α-bromoglutaric acid diester. To estimate their biological efficacies as well as their stability and radiochemistry, the RRR/SSS and RRS/SSR NOTGA-tBu prochelators were isolated and the corresponding cyclic RGDfK (RGD) conjugates ...
Yamamoto Kenta - - 2012
Detection of shiikuwasha (Citrus depressa Hayata) juice adulterated with calamondin (Citrus madurensis LOUR.) juice was investigated by the analyses of (1) phloretin dihydrochalcone glucoside, 3',5'-di-C-β-glucopyranosylphloretin (PD), detected by thin-layer chromatography and high performance liquid chromatography (HPLC); (2) polymethoxylated flavones (PMFs) included nobiletin, tangeretin and sinensetin detected by HPLC; and (3) ...
Huang Yuhui Y Edwin L Steele Laboratory of Tumor Biology, Department of Radiation Oncology and Vaccine and Immunotherapy Center, Infectious Diseases Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, - - 2012
The recent approval of a prostate cancer vaccine has renewed hope for anticancer immunotherapies. However, the immunosuppressive tumor microenvironment may limit the effectiveness of current immunotherapies. Antiangiogenic agents have the potential to modulate the tumor microenvironment and improve immunotherapy, but they often are used at high doses in the clinic ...
Shonkoff Jack P - - 2012
Extensive evidence that personal experiences and environmental exposures are embedded biologically (for better or for worse) and the cumulative knowledge of more than four decades of intervention research provide a promising opportunity to mobilize evolving scientific insights to catalyze a new era of more effective early childhood policy and practice. ...
Reid Chris R - - 2012
Spatial memory enhances an organism's navigational ability. Memory typically resides within the brain, but what if an organism has no brain? We show that the brainless slime mold Physarum polycephalum constructs a form of spatial memory by avoiding areas it has previously explored. This mechanism allows the slime mold to ...
Feucht W - - 2012
Normally, needles of Taxus baccata during the growth period prominently stain blue for nuclear flavanols with the histochemical DMACA procedure. However, under excess heat and drought conditions, nuclear flavanols of current-year needles decline to zero. Nevertheless, greenish-yellow-coloured flavonols (quercetin derivatives) were still observed in nuclei. All of these yellow nuclei ...
Fok Henry - - 2012
Arterial tone in muscular conduit arteries may influence pressure wave reflection through changes in diameter and pulse wave velocity. We examined the relative specificity of vasodilator drugs for radial artery and forearm resistance vessels during intrabrachial arterial infusion. The nitric oxide (NO) donors, nitroglycerine and nitroprusside, and brain natriuretic peptide ...
Kulaeva Olga I - - 2012
Enhancers are regulatory DNA sequences that activate transcription over long distances. Recent studies revealed a widespread role of distant activation in eukaryotic gene regulation and in development of various human diseases, including cancer. Genomic and gene-targeted studies of enhancer action revealed novel mechanisms of transcriptional activation over a distance. They ...
Estabrooks Paul A - - 2012
The Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) model was developed to improve the likelihood of translating health promotion intervention research into practice. In their evaluation of grant proposals focusing on the dissemination and implementation, Kessler and colleagues (2012) proposed a method for evaluating the degree to which RE-AIM was "fully ...
Martin C E - - 2012
Leaf temperatures were lower when light entry at the leaf tip window was prevented through covering the window with reflective tape, relative to leaf temperatures of plants with leaf tip windows covered with transparent tape. This was true when leaf temperatures were measured with an infrared thermometer, but not with ...
Duque Gustavo - - 2012
Infiltration of bone marrow with fat is a prevalent feature in people with age-related bone loss and osteoporosis, which correlates inversely with bone formation and positively with high expression levels of peroxisomal proliferator-activated receptor gamma (PPARγ). Inhibition of PPARγ thus represents a potential therapeutic approach for age-related bone loss. In ...
Li Changying - - 2012
Studies with a number of viral systems have shown, on the basis of the ability of a host to prime naïve T cells, that viral antigens persist in the infected host well beyond complete clearance of the infection and even when viral antigen is undetectable by the most sensitive methods. ...
Allouche Omri - - 2012
For more than 50 y ecologists have believed that spatial heterogeneity in habitat conditions promotes species richness by increasing opportunities for niche partitioning. However, a recent stochastic model combining the main elements of niche theory and island biogeography theory suggests that environmental heterogeneity has a general unimodal rather than a ...
Essving Per - - 2012
There has recently been interest in the advantages of minimally invasive surgery (MIS) over conventional surgery, and on local infiltration analgesia (LIA) during knee arthroplasty. In this randomized controlled trial, we investigated whether MIS would result in earlier home-readiness and reduced postoperative pain compared to conventional unicompartmental knee arthroplasty (UKA) ...
Sibon David - - 2012
PURPOSESystemic anaplastic large-cell lymphoma (ALCL) is a T-cell lymphoma, whose anaplastic lymphoma kinase (ALK) expression varies according to age. Long-term outcomes of chemotherapy-treated adults are not definitively established and should be evaluated. PATIENTS AND METHODSPatients treated in three Groupe d'Étude des Lymphomes de l'Adulte prospective clinical trials with confirmed systemic ...
Wagner Thor A TA Seattle Children's Research Institute, Seattle, Washington 98101, USA. - - 2013
Non-invasive diagnostic assays to evaluate mitochondrial toxicity could have significant clinical utility for HIV-infected individuals on antiretroviral therapy (ART). This study compared the ratio of mitochondrial to nuclear DNA determined by quantitative polymerase chain reaction (qPCR) to the ratio of mitochondrial to nuclear-encoded proteins by flow cytometry, in peripheral blood ...
Maia Ana R R AR Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, - - 2012
Accurate chromosome segregation during mitosis relies on a dynamic kinetochore (KT)-microtubule (MT) interface that switches from a labile to a stable condition in response to correct MT attachments. This transition is essential to satisfy the spindle-assembly checkpoint (SAC) and couple MT-generated force with chromosome movements, but the underlying regulatory mechanism ...
Munde Elly O - - 2012
An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors (FcγRs) mediate immunity through engagement of immunoglobulin G and other immune mediators, such as gamma interferon (IFN-γ), resulting in ...
Imajoh Masayuki - - 2012
In Japan, Mycobacterium sp. was isolated from the yellowtail, Seriola quinqueradiata, as a Mycobacterium marinum-like mycobacterium. The species was identified as M. marinum by a commercial mycobacterial DNA-DNA hybridization kit. Nevertheless, PCR restriction analysis of DNA of the RNA polymerase β-subunit gene definitively showed that Mycobacterium sp. is M. ulcerans. ...
Hsu Y-L - - 2012
The skeleton is the most common metastatic site for breast cancer, with bone metastasis causing pain as well as risk of pathological fractures. Interaction between tumors and the bone microenvironment creates a vicious cycle that accelerates both bone destruction and cancer progression. This study is the first to analyze the ...
Okuma Kentaro - - 2012
An efficient route to 4-aryl-2-naphthols from arynes and aroylacetones was developed by carbon-carbon bond insertion followed by an intramolecular aldol reaction and dehydration. Benzyne derived from 2-(trimethylsilyl)phenyl triflate reacted with benzoylacetones in refluxing acetonitrile to give 4-aryl-2-naphthols and 3-aryl-1-naphthols.
Santos Karine F - - 2012
Assembly of a spliceosome, catalyzing precursor-messenger RNA splicing, involves multiple RNA-protein remodeling steps, driven by eight conserved DEXD/H-box RNA helicases. The 250-kDa Brr2 enzyme, which is essential for U4/U6 di-small nuclear ribonucleoprotein disruption during spliceosome catalytic activation and for spliceosome disassembly, is the only member of this group that is ...
Clark Nathaniel E - - 2012
Schindler/Kanzaki disease is an inherited metabolic disease with no current treatment options. This neurologic disease results from a defect in the lysosomal α-N-acetylgalactosaminidase (α-NAGAL) enzyme. In this report, we show evidence that the iminosugar DGJNAc can inhibit, stabilize, and chaperone human α-NAGAL both in vitro and in vivo. We demonstrate ...
Jung Da-Woon - - 2012
Muscle diseases are major health concerns. For example, ischemic heart disease is the third most common cause of death. Cell therapy is an attractive approach for treating muscle diseases, although this is hampered by the need to generate large numbers of functional muscle cells. Small molecules have become established as ...
Favia Angelo D - - 2012
Pain and inflammation are major therapeutic areas for drug discovery. Current drugs for these pathologies have limited efficacy, however, and often cause a number of unwanted side effects. In the present study, we identify the nonsteroidal anti-inflammatory drug carprofen as a multitarget-directed ligand that simultaneously inhibits cyclooxygenase-1 (COX-1), COX-2, and ...
Miller Kelly A - - 2012
Numerous virulence factors have been associated with pathogenic non-O1/non-O139 serogroup strains of Vibrio cholerae. Among them are the thermostable direct hemolysin (TDH) and the TDH-related hemolysin (TRH), which share amino acid similarities to the TDH and TRH proteins of Vibrio parahaemolyticus, where they have been shown to contribute to pathogenesis. ...
Hügle Thomas - - 2012
OBJECTIVE.: The role of tumor necrosis factor (TNF) in Systemic Sclerosis (SSc) remains controversial. We aimed to investigate the influence of TNF receptor (TNFR) co-stimulated lymphocytes on collagen expression in fibroblasts. METHODS.: TNFR expression on mononuclear cells from dermis and blood of SSc patients was assessed by flow cytometry. Peripheral ...
Adel-Patient K - - 2012
The immunomodulatory potential of fragments derived from the cow's milk allergen bovine ß-lactoglobulin (BLG) was assessed in a mouse model of oral tolerance (OT). Native BLG (nBLG) and chemically denatured BLG (lacking S-S bridges, dBLG), products resulting from their hydrolysis using cyanogen bromide (CNBr) and some synthetic peptides were produced ...
Chimge N-O - - 2012
The three RUNX family members are lineage specific master regulators, which also have important, context-dependent roles in carcinogenesis as either tumor suppressors or oncogenes. Here we review evidence for such roles in breast cancer (BCa). RUNX1, the predominant RUNX family member in breast epithelial cells, has a tumor suppressor role ...
Duan Deyong - - 2012
The sinus node of yak has been studied by the histological methods and transmission electron microscopy. The sinus node artery of yak was also determined by the injection-corrosion casting technique, the angiography, and histological methods. The results showed that the sinus node of yak contained an extensive framework of collagen ...
Duncan Jeremy S - - 2012
Here, we review the molecular basis of mechanosensory cell and mechanosensory organ development and evolution with an emphasis on the conservation of transcription factors and emerging data on conserved gene networks. The ear, the organ of vertebrates dedicated to the perception of sound and balance, perceives these stimuli with the ...
Yang Eun-Jin - - 2012
Preference behaviors are often established during early life, but the underlying neural circuit mechanisms remain unknown. Adapting a unique nesting behavior assay, we confirmed a "critical period" for developing music preference in C57BL/6 mice. Early music exposure between postnatal days 15 and 24 reversed their innate bias for silent shelter, ...
Bertrand Olivier J N - - 2012
Cells are capable of a variety of dramatic stimuli-responsive mechanical behaviors. These capabilities are enabled by the pervading cytoskeletal network, an active gel composed of structural filaments (e.g., actin) that are acted upon by motor proteins (e.g., myosin). Here, we describe the synthesis and characterization of an active gel using ...
de Souza E O - - 2012
This study investigated the chronic effects of concurrent training (CT) on morphological and molecular adaptations. 37 men (age=23.7±5.5 year) were divided into 4 groups: interval (IT), strength (ST) and concurrent (CT) training and a control group (C) and underwent 8 weeks of training. Maximum strength (1RM) and muscle cross-sectional area ...
Yu Han-Jie - - 2012
Protein glycosylation plays an important role in the pathogenesis and progression of various liver diseases. However, little is known about the precise alterations in protein glycosylation or the potential correlation between glycan-related genes expression and glycan profiles in liver fibrosis. The aim of the study was to investigate potential associations ...
Keller Rebecca R Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, Scotland, - - 2012
Membrane protein assembly is a fundamental process in all cells. The membrane-bound Rieske iron-sulfur protein is an essential component of the cytochrome bc(1) and cytochrome b(6)f complexes, and it is exported across the energy-coupling membranes of bacteria and plants in a folded conformation by the twin arginine protein transport pathway ...
Yu Haibo - - 2012
A lysosome-specific and two-photon fluorescent probe Lyso-NINO demonstrates high selectivity and sensitivity toward NO, lower cytotoxicity and perfect lysosomal localization. With the aid of Lyso-NINO, the first NO's capture within lysosomes of macrophage cells has been achieved in both two-photon fluorescent microscopy and flow cytometry.
Siddhanta Soumik - - 2012
We demonstrate here a novel high surface area GaN nanowall network substrate with plasmonic Ag nanodroplets, that can be employed as a highly sensitive, reproducible and charge independent SERS substrate. The uniformity of the size and distribution of the Ag droplets and the absence of linker ligands, result in large ...
Yousefi Reza - - 2012
The needs for diverse inhibitors of α-glucosidase (α-Gls) encouraged us to synthesize five different poly-hydroxy functionalized pyrimidine-fused heterocyclic (PHPFH) molecules, having either aliphatic or aromatic side chains (C(1)-C(5)) and their inhibitory activities were examined spectroscopically against yeast and mouse intestinal α-Gls. The results revealed that aromatic substitution of the synthetic ...
Hwang Shin - - 2012
In liver transplantation, a left lateral section (LLS) graft may have unusual variant left hepatic vein (LHV) anatomy. This study was designed to analyze the incidence of unusual variant LHV and to determine technical methods for its effective reconstruction in infant recipients weighing around 10 Kg or less. The study ...
Broom Alex F - - 2012
Cancer is emerging as a key disease in India, but there has been virtually no research exploring understandings of cancer and practices of communication within oncology settings. This is despite the fact that the Indian context presents clinicians, patients, and family members with a range of unique challenges, including those ...
Banczerowski Péter - - 2012
Background The conventional posterior approaches, which may involve multilevel laminectomies and facetectomies, may lead to spinal deformities, instability, or subluxation. Our objective was to develop a minimally invasive approach suitable for exploring neuromas with an intraforaminal component in the cervical spine, with the aim of preserving mechanically relevant bone structures and ...
Hall John C - - 2012
Elucidating the molecular pathways active in pathologic tissues has important implications for defining disease subsets, selecting therapy, and monitoring disease activity. The development of therapeutics directed at IFN-α or IFN-γ makes the discovery of probes that report precisely on the activity of different IFN pathways a high priority. We show ...
Berr Maximilian J - - 2012
We introduce size-selected subnanometer cluster catalysts deposited on thin films of colloidal semiconductor nanocrystals as a novel platform to obtain atomic scale insight into photocatalytic generation of solar fuels. Using Pt-cluster-decorated CdS nanorod films for photocatalytic hydrogen generation as an example, we determine the minimum amount of catalyst necessary to ...
Giménez-Benavides L - - 2012
Seeds of high-mountain species are thought to germinate rapidly, synchronously and at high percentages after a cold period, with limited dependence on the external environment; yet, empirical evidence only partially supports this behaviour. We performed a comparative study of the germination response of two closely related taxa along an altitude ...
Witt Benjamin L - - 2012
Background: Fine needle aspiration (FNA) with ultrasound guidance is one of the optimal techniques for the diagnostic evaluation of thyroid nodules. A significant subset of thyroid FNAs continue to be inadequate for interpretation, which potentially leads to increased costs from repeat aspirations. Numerous studies have been published regarding the influence ...
Papaz Tanya - - 2012
BACKGROUND:Consenting minors for genetics research and biobanking involves ethical and social challenges. We examined factors influencing participation rates in a population-based biorepository for childhood heart disease.METHODS:Individuals were prospectively enrolled across 7 centers in Ontario by using a standardized consent form. Individuals were approached for consent for the donation of blood/saliva ...
Li Yin-Ji - - 2012
Nordihydroguaiaretic acid (NDGA) is known to have prominent anticancer activity against several cancers, and is also known to be an inhibitor of 5-lipoxygenase (5-LO). In this study, we investigated the regulatory function of NDGA on inflammatory bone destruction mediated by osteoclasts. NDGA markedly inhibited receptor activator of nuclear factor-κB (NF-κB) ...
Storm Benjamin C - - 2012
There is a positivity bias in autobiographical memory such that people are more likely to remember positive events from their past than they are to remember negative ones. Inhibition may promote this positivity bias by deterring negative memories from being retrieved. In our first experiment, we measured individual differences in ...
Barrère Caroline - - 2012
Polyolefin, including polypropylene (PP), constitutes an important class of materials. In particular, the recent interest in recycling plastic wastes necessitates their characterization as well as their degradation mechanism understood. PP materials characterization by mass spectrometry, including polymer and additives parts, is not direct and generally involves a pyrolysis step to ...
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