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Results 401 - 450 of 2041
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Gomez Francisco L Guerra - - 2012
In the conventional synthesis of 1,4,7-tris-(glutaric acid)-1,4,7-triazacyclononane (NOTGA), four isomeric species are usually generated by the alkylation of 1,4,7-triazacyclononane with α-bromoglutaric acid diester. To estimate their biological efficacies as well as their stability and radiochemistry, the RRR/SSS and RRS/SSR NOTGA-tBu prochelators were isolated and the corresponding cyclic RGDfK (RGD) conjugates ...
Yamamoto Kenta - - 2012
Detection of shiikuwasha (Citrus depressa Hayata) juice adulterated with calamondin (Citrus madurensis LOUR.) juice was investigated by the analyses of (1) phloretin dihydrochalcone glucoside, 3',5'-di-C-β-glucopyranosylphloretin (PD), detected by thin-layer chromatography and high performance liquid chromatography (HPLC); (2) polymethoxylated flavones (PMFs) included nobiletin, tangeretin and sinensetin detected by HPLC; and (3) ...
Ambler Dana R - - 2012
Inflammation is known to be involved in the postoperative adhesion development. Interleukin (IL)-6 and tumor necrosis factor (TNF)-α are cytokines that stimulate the acute-phase reaction, which leads to a systemic reaction including inflammation, fever, and activation of the complement and clotting cascades. The goal of this study was to examine ...
Cutting Richard Simon - - 2012
To address the impact of microbial redox cycling on arsenic-bearing acid mine drainage minerals, the fate of As(V) during the microbial reduction of Fe(III) in synthetic As-bearing schwertmannites by Geobacter sulfurreducens has been investigated. During incubation, the initial rate of biological Fe(III) reduction increased with increased initial arsenic concentration. From ...
Liu Binghang - - 2012
MOTIVATION: The boost of next-generation sequencing technologies provides us with an unprecedented opportunity for elucidating genetic mysteries, yet the short read length hinders us from better assembling the genome from scratch. New protocols now exist that can generate overlapping pair-end reads. By joining the 3'-ends of each read pair, one ...
Hart Aaron - - 2012
Effect of positioning of the cyanoacrylic acid anchoring group on ring periphery of phenothiazine dye on the performance of dye sensitized solar cells (DSSCs) is reported. Two types of dyes, one having substitution on the C-3 aromatic ring (Type-1), and another through the N-terminal (Type-2) have been synthesized for this ...
Gery S - - 2012
The signal transduction pathways, orchestrating the differentiation of hematopoietic stem and progenitor cells in response to cytokine stimulation, are strictly controlled by networks of feedback loops, highly selective protein interactions and finely tuned on/off switches. In hematological malignancies, the aberrant activation of signaling pathways is usually associated with mutations in ...
Etgar Lioz - - 2012
We report for the first time on a hole conductor-free mesocopic lead iodide CH3NH3PbI3(perovskite)/TiO2 heterojunction solar cell, produced by deposition of perovskite nanoparticles from a solution of CH3NH3I and PbI2 in γ-butyrolactone on a 400nm thick film of TiO2 (anatase) nanosheets exposing (001) facets. An Au film was evaporated a ...
Rattaz Cecile - - 2012
This study focused on parents' satisfaction with the special education and care services proposed to their child with autism spectrum disorders (ASD). Data were collected in three regions of France, using a questionnaire designed for the purpose of this study. Among the 530 families contacted, 212 filled in the questionnaire ...
Danielson Michelle E - - 2012
Racial/ethnic origin plays an important role in fracture risk. Racial/ethnic differences in fracture rates cannot be fully explained by bone mineral density (BMD). Studies examining the influence of bone geometry and strength on fracture risk have focused primarily on older adults and have not included people from diverse racial/ethnic backgrounds. ...
Guo Mei - - 2012
PURPOSEDespite best current therapies, approximately half of patients with acute myeloid leukemia in first complete remission (AML-CR1) with no HLA-identical donors experience relapse. Whether HLA-mismatched stem-cell microtransplantation as a novel postremission therapy in these patients will improve survival and avoid graft-versus-host disease (GVHD) is still unknown. PATIENTS AND METHODSOne hundred ...
Leinberger Rebecca L - - 2012
OBJECTIVE To investigate the perspectives of vision care providers (VCPs) on inquiring about driving among their older adult patients. METHODS We surveyed a stratified random sample of 500 VCPs, 404 of whom completed the survey (response rate, 80.8%), who had been identified using membership lists of the Michigan Optometric Association ...
Musch David C - - 2012
OBJECTIVES To characterize situations that prompt vision care providers (VCPs) to ask about their older patients' driving, the types of information they consider, and the factors that influence these inquiries. METHODS A survey was conducted among a random sample of 500 VCPs who were active members of their Michigan professional ...
Bories Phuong-Nhi - - 2012
BACKGROUND:Current methods for detecting TMPRSS2-ERG fusion transcript in the urine of patients with suspected prostate cancer lack diagnostic sensitivity. We combined urine and prostate biopsy rinse material (BRM) assays to improve the fusion gene detection rate.METHODS:Eighty patients with clinical and/or prostate-specific antigen suspicion of prostate cancer were prospectively included in ...
Zhu Weiwei - - 2012
Background Stromal cell-derived factor-1 (SDF-1) plays a critical role in adult brain injury repair including neurogenesis and vasculogenesis. However, the effects of recombinant SDF-1(rSDF-1) treatment on hypoxic-ischemic (HI) brain injury in neonatal mice are not clear.Materials and Methods Seven-day-old (P7) C57BL/6J mice were divided into sham group, control group, and rSDF-1 group. ...
van Diepen Harry A - - 2012
ABSTRACT: BACKGROUND: Nomegestrol acetate (NOMAC), a synthetic progestogen derived from 19-nor-progesterone, recently completed clinical trials for use with 17beta-estradiol in a new monophasic combined oral contraceptive. In this review, published as well as previously unpublished preclinical studies that detail the effects of NOMAC on estrogenic, progestogenic and androgenic systems, as ...
Hariri Susan - - 2012
Background. Two vaccines protect against human papillomaviruses (HPV) 16 and 18 that cause 70% of cervical cancer and 50% of cervical intraepithelial neoplasia 2/3 and adenocarcinoma in situ (CIN2+). Monitoring HPV types in CIN2+ may be used to assess HPV vaccine impact.Methods. As part of a multi-site vaccine impact monitoring project (HPV-IMPACT), ...
Zamboanga Byron L - - 2012
OBJECTIVES: To examine how legal age status, gender, and self-reported reasons for pregaming are linked to pregaming for two common drinking contexts: a bar and a Greek party. METHOD: Participants who reported pregaming at least once a month (n = 2888 students aged 18-25 years) were recruited from 30 colleges/universities ...
Eshraghi Adrien A - - 2012
The cochlear implant (CI) is the first effective treatment for deafness and severe losses in hearing. As such, the CI is now widely regarded as one of the great advances in modern medicine. This article reviews the key events and discoveries that led up to the current CI systems, and ...
Prodoehl Janey - - 2012
OBJECTIVE To compare differences in functional brain activity between tremor- and nontremor-dominant subtypes of Parkinson disease (PD) using functional magnetic resonance imaging. DESIGN In our study, patients with tremor-dominant PD and those with nontremor-dominant PD performed a grip task, and the results obtained were compared using voxelwise analysis. Areas of ...
Yu Xue-Fang - - 2012
Excited-state multiple proton transfer (ESMPT) in the cluster of 7-azaindole with three water molecules [7-azaindole(H2O)3] is theoretically investigated by the TDDFT, CASPT2, and CC2 methods. Examination of the potential energy surface in the first excited state indicates that ESMPT in 7-azaindole(H2O)3 proceeds initially with the rearrangement of hydrogen bond structure ...
Patkar Rajesh N - - 2012
Fatty acids stored as triglycerides, an important source of cellular energy, are catabolized through β-oxidation pathways predicted to occur both in peroxisomes and mitochondria in filamentous fungi. Here, we characterize the function of Enoyl-CoA hydratase Ech1, a mitochondrial β-oxidation enzyme, in the model phytopathogen Magnaporthe oryzae. Ech1 was found to ...
Aminkeng Folefac - - 2012
Loss-of-function mutations in HINT1 cause axonal neuropathy with neuromyotonia ZimoĊ„ M et al. (2012). Nat Genet. 2012 Sep 9. doi: 10.1038/ng.2406. [Epub ahead of print].
Naro-Maciel Eugenia - - 2012
Current understanding of spatial ecology is insufficient in many threatened marine species, failing to provide a solid basis for conservation and management. To address this issue for globally endangered green turtles, we investigated their population distribution by sequencing a mitochondrial control region segment from the Rocas Atoll courtship area (n ...
Vellanki Haritha - - 2012
BACKGROUND AND OBJECTIVE:Pneumothorax is common in very low birth weight (VLBW) infants. In our NICU, we noted an above average incidence of pneumothorax compared with similar NICUs based on Vermont Oxford Network benchmarking. The quality improvement project was designed to decrease the incidence of pneumothorax in VLBW infants in a ...
Azizi Michel - - 2012
Aldosterone synthase (CYP11B2) inhibition has emerged as a new option for the treatment of hypertension, heart failure and renal disorders, in addition to mineralocorticoid receptor (MR) blockade. The aim is to decrease aldosterone concentrations in both plasma and tissues, thereby decreasing MR-dependent and MR-independent effects in the cardiac, vascular and ...
Cristiano E - - 2012
The incidence and prevalence of multiple sclerosis (MS) varies geographically as shown through extensive epidemiological studies performed mainly in developed countries. Nonetheless, scant data is available in Latin America and the Caribbean (LAC). The objective of this review is to assess epidemiological data of MS in LAC. We conducted a ...
Janda J Michael - - 2012
The genus Shewanella is currently composed of more than 50 species that inhabit a range of marine environs and ecosystems. Several members of this genus, including S. oneidensis, have been identified that could potentially play key roles in environmental processes such as bioremediation of toxic elements and heavy metals and ...
Ekra Else Mari Ruberg - - 2012
Hospital conditions for children have changed dramatically over the last decades. Until recently, hospitalised children were left without their parents in an environment that was not adapted to children. In the period 1950-1980, hospitalised children did not have a voice. The aim of this Norwegian study was to use adult ...
Sanchez-Moreno Manuel - - 2012
A series of new phthalazine derivatives 1-4 containing imidazole rings were prepared. The monoalkylamino substituted derivatives 2 and 4 were more active in vitro against T, cruzi and less toxic against Vero cells than both their disubstituted analogs and the reference drug benznidazole. Compounds 2 and 4 highly inhibited the ...
Munkholm Klaus - - 2012
Munkholm K, Vinberg M, Berk M, Kessing LV. State-related alterations of gene expression in bipolar disorder: a systematic review. Bipolar Disord 2012: 00: 000-000. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objective:  Alterations in gene expression in bipolar disorder have been found in numerous ...
Kerr D M - - 2012
BACKGROUND AND PURPOSE: This study determined the effect of JZL184, a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme which preferentially catabolises the endocannabinoid 2-arachidonoyl glycerol (2-AG), on inflammatory cytokines in the brain and plasma following an acute immune challenge. The receptor and molecular mechanisms involved were also investigated. EXPERIMENTAL ...
Hwang Huei-Lih - - 2012
BACKGROUND: Until now, caring research has focused on constructs, processes and outcomes of caring traits exhibited mainly by nurses or nursing students in hospitals. Few studies have considered the perspectives of elderly residents of long-term care facilities (LTCFs). AIMS: The aim of this study was to elucidate the nature of ...
Geng Wan-Li - - 2012
Herbarone (1), a novel heptaketide with a tetrahydro-5,9-methanobenzo[8]annulen-10(5H)-one skeleton, together with the new ent-astropaquinones B (2) and C (3) and four known pyranonaphthoquinones (4-7), was isolated from the sea hare associated fungus Torula herbarum. The structures of the new compounds were elucidated by detailed spectroscopic analysis, and the absolute configurations ...
Collodel Giulia - - 2012
Semen from 33 patients were evaluated by light microscopy (LM) obtaining sperm concentration, percent motility, percentage of sperm with normal morphology (PAP staining), and percentage of dead sperm (Eosin Y stained). The samples were observed by polarizing microscopy (PM), that evaluates sperm morphology and the viability by birefringence of organelles, ...
Kosmala Arkadiusz - - 2012
Festuca arundinacea is one of the most drought-tolerant species within the Lolium-Festuca complex and was used as a model for research aimed at identifying the chloroplast components involved in the proteomic response for drought stress in forage grasses. Individual F. arundinacea genotypes with contrasting levels of drought tolerance, the high-drought-tolerant ...
Ohmura Toshimichi - - 2012
A methyl group of methylchlorosilanes undergoes C-H borylation in an iridium-catalyzed reaction with bis(pinacolato)diboron in cyclohexane at 80 °C, giving (borylmethyl)chlorosilanes selectively.
Lee Chanhui - - 2012
Xylan is made of a linear chain of β-1,4-linked xylosyl residues, some of which are substituted with side chains, such as glucuronic acid (GlcA), methylglucuronic acid (MeGlcA) and arabinose depending on the source of xylan. Although past studies have revealed a number of genes involved in the elongation of the ...
Okun Michael S - - 2012
OBJECTIVE To collect the information necessary to design the methods and outcome variables for a larger trial of scheduled deep brain stimulation (DBS) for Tourette syndrome. DESIGN We performed a small National Institutes of Health-sponsored clinical trials planning study of the safety and preliminary efficacy of implanted DBS in the ...
Guerreiro Rita João - - 2012
OBJECTIVE To identify new genes and risk factors associated with frontotemporal dementia (FTD). Several genes and loci have been associated with different forms of FTD, but a large number of families with dementia do not harbor mutations in these genes. DESIGN Whole-exome sequencing and whole-genome genotyping were performed in all ...
Eftaiha Ala - - 2012
Monolayer surfactant films comprised of a mixture of phospholipids and perfluorinated (or partially fluorinated) surfactants are of potential utility for applications in pulmonary lung surfactant-based therapies. As a simple, minimal model of such a lung surfactant system, binary mixed monolayer films comprised of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and perfluorooctadecanoic acid (C18F) prepared ...
Pinedo M - - 2012
Several apoplastic enzymes have been implicated in the control of elongation growth of plant cells. Among them, peroxidases contribute to both loosening and stiffening of the cell wall. They appear to be regulated by various mechanisms, including the action of extracellular inhibitors. To obtain evidence of the role of the ...
Dummer Reinhard - - 2012
PURPOSEMycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. There is a need for multicenter trials involving defined patient populations using rigorous assessment criteria. We have investigated pegylated liposomal doxorubicin (PLD) in a clearly defined patient population with advanced MF. PATIENTS AND METHODSEligible patients had stage IIB, IVA, ...
van Beers Joyce J B C - - 2012
OBJECTIVE: This study aimed to generate a catalog of citrullinated proteins present in the synovia of rheumatoid arthritis (RA) patients and to elucidate their relevance for the anti-citrullinated protein antibody response in RA. METHODS: Polypeptides isolated from RA patient synovial fluid were identified by mass spectrometry. Three proteins (apolipoprotein E, ...
Warren-Gash Charlotte - - 2012
Please cite this paper as: Warren-Gash et al. (2012) Hand hygiene to reduce community transmission of influenza and acute respiratory tract infection: a systematic review. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12015. Hand hygiene may be associated with modest protection against some acute respiratory tract infections, but its specific role in ...
Rask-Andersen Helge - - 2012
This is a review of the anatomical characteristics of human cochlea and the importance of variations in this anatomy to the process of cochlear implantation (CI). Studies of the human cochlea are essential to better comprehend the physiology and pathology of man's hearing. The human cochlea is difficult to explore ...
Han Ying - - 2012
Triptycene-based macrotricyclic host containing two dibenzo-30-crown-10 moieties could form ladder-like supramolecular poly[3]pseudorotaxanes with π-extended viologens in both high concentration solution and solid state.
Sharma Punit - - 2012
ABSTRACT The purpose of this study was to evaluate the role of 18F-Fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) for detecting relapse in post treatment patients of primary gastric lymphoma (PGL). Data of 39 previously treated PGL patients (Age: 50.3±13.8 years; Male: 24) who underwent 71 (18)F-FDG PET-CT for suspected ...
Wang Yan - - 2012
OBJECTIVES To develop a reliable, reproducible rat model of posterior ischemic optic neuropathy (PION) and study the cellular responses in the optic nerve and retina. METHODS Posterior ischemic optic neuropathy was induced in adult rats by photochemically induced ischemia. Retinal and optic nerve vasculature was examined by fluorescein isothiocyanate-dextran extravasation. ...
Hentrich Marcus - - 2012
Although the outcome of patients with HIV-related Hodgkin lymphoma (HIV-HL) has markedly improved since the introduction of combined antiretroviral therapy, standard therapy is still poorly defined. This prospective study investigates a stage- and risk-adapted treatment strategy in patients with HIV-HL. Patients with early favorable HIV-HL received two to four cycles ...
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