Search Results
Results 251 - 300 of 2040
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Jacobson George Lloyd - - 2012
Between 45,000 cal y BP and the beginning of the Holocene, the accumulation rate for Hg in sediments of Lake Tulane, Florida USA ranged from ≈2 to 10 µg m-2 y-1, compared with 53 µg Hg m-2 y-1 in the 1985-1990 period of anthropogenic input. The locality experienced regional draw-down ...
Montgomery Robbie K RK Department of Biomedical Engineering and South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas 78249, - - 2013
Refrigeration of platelets (PLTs) offers an attractive alternative to the currently practiced storage at room temperature since it may mitigate problems associated with bacterial contamination and extend storage lifetime. Refrigeration causes a number of biophysical and biochemical changes in PLTs and decreases PLT circulation time in vivo. However, the effect ...
Masuda Shigeo S Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, - - 2013
Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via ...
Elliott Timothy G - - 2012
BACKGROUND/OBJECTIVES: Dermatologists commonly perform surgical procedures, including Mohs micrographic surgery, in an outpatient, office-based setting. Although this may be widely perceived to be safe and effective, formal data on the practice are limited. The aim of this study was to examine the range of surgical procedures and associated complications in ...
Sattar Akm A - - 2012
Adiponectin (Adp), an adipocyte secreted hormone, exerts its effect via its specific receptors, adiponectin receptors (AdipoR1 and AdipoR2), in insulin sensitive cells in muscle, liver, and adipose tissues and plays an important role in lipid and glucose metabolism. The aim of the current study was to investigate the effect of ...
Digirolamo Douglas J - - 2012
Surprising new discoveries in the field of skeletal biology show that bone cells produce endocrine hormones that regulate phosphate and glucose homeostasis. In this Review, we examine the features of these new endocrine pathways and discuss their physiological importance in the context of our current understanding of energy metabolism and ...
Lock Nina - - 2012
Complementary experimental techniques and ab initio calculations were used to determine the origin and nature of negative thermal expansion (NTE) in the archetype metal-organic framework MOF-5 (Zn(4)O(1,4-benzenedicarboxylate)(3)). The organic linker was probed by inelastic neutron scattering under vacuum and at a gas pressure of 175 bar to distinguish between the ...
Han Moon Gyu - - 2012
An electrically tunable photonic crystal is developed utilizing crystalline colloidal arrays of high refractive index particles. Through modulation of the refractive index of the particle, and the applied electric field, both the bandwidth and position of the photonic bandgap could be tuned. Full color modulation with high optical quality is ...
Lyseng-Williamson Katherine A - - 2012
Melatonin prolonged release (PR) 2 mg is approved for the treatment of primary insomnia characterized by poor sleep quality in patients aged ≥55 years in the EU and elsewhere. Patients may receive treatment with melatonin PR for up to 13 weeks. Production of endogenous nocturnal melatonin, which helps regulate circadian rhythm, may be ...
- - 2012
The following articles are being highlighted as part of Circulation's Topic Review series. This series will summarize the most important manuscripts, as selected by the editors, published in Circulation and the Circulation subspecialty journals. The studies included in this article represent the most read manuscripts published on the topic of ...
Cui C - - 2012
We report a study of the atomic structure of the threefold icosahedral (i-)Ag-In-Yb quasicrystal surface using scanning tunneling microscopy (STM) and low energy electron diffraction (LEED). The LEED confirms that the surface exhibits quasicrystalline long-range order with the threefold symmetry expected from the bulk. The STM reveals large atomically flat ...
Andrzejczak Ewa - - 2012
BACKGROUD: The present study assessed the degree to which undergoing a mastectomy without reconstructive surgery negatively impacts the patient's psychological state. We focus on body image and self-esteem as well as the influence of mastectomy on patient sex lives and partnership relations. METHODS: The participants were 60 women, either married ...
Sivertsen Børge - - 2012
Several studies have indicated a high degree of overlap between insomnia and obstructive sleep apnoea, but little is known regarding how the overlap may affect adverse outcomes associated with each of the disorders. The aim of the current study was to examine the separate and combined effects of symptoms of ...
Frawley Geoff G Department of Paediatric Anaesthesia and Pain Management, Royal Children's Hospital, Melbourne, Vic., Australia. - - 2013
To document the incidence of difficult intubation following mandibular distraction osteogenesis (MDO) in children with severe mandibular hypoplasia. Syndromes associated with significant mandibular hypoplasia, especially Pierre Robin sequence, provide a challenge in airway management both in and out of the operating room. Mandibular advancement using mandibular distraction osteogenesis devices has ...
Furlotti Guido - - 2012
Since the discovery of 5-HT4R a large number of receptor ligands have been studied. The safety concerns and the lack of market success of these ligands have mainly been attributed to their lack of selectivity. In this study we describe the discovery of N-[(4-piperidinyl)methyl]-1H-indazole-3-carboxamide and 4-[(4-piperidinyl)methoxy]-2H-pyrrolo[3,4-c]quinoline derivatives as new 5-HT4R ...
Li Feng - - 2012
Fluorination: A wide range of nitroolefins and pyrazol-5-ones undergo a sequential 1,4-addition/dearomative-fluorination transformation when treated with a catalytic amount of a tertiary-amine-thiourea compound and the terminal electrophile, N-fluorobenzenesulfonimide to give fluorinated products in 72-95 % yield with up to 99:1 d.r. and 98 % ee. Notably, these products contain adjacent tertiary and α-fluoro ...
Champagne Antoine - - 2012
Madagascar periwinkle (Catharanthus roseus) is the major source of terpenoid indole alkaloids, such as vinblastine or vincristine, used as natural drugs against various cancers. In this study, we have extensively analyzed the proteome of cultured C. roseus cells. Comparison of the proteomes of two independent cell lines with different terpenoid ...
Lam David Cl - - 2012
We are witnessing a rapid transformation of clinical practice as more of what we do in medicine becomes informed by an increasingly accelerated application of scientific knowledge derived from basic science research. This process represents the essence of what is now termed clinical translational research, which entails the infusion of ...
Barratt Monica J - - 2012
INTRODUCTION AND AIMS: To assess the demographic profile, use patterns, market characteristics, reasons for first use and self-reported harms associated with use of synthetic cannabinoids in Australia. DESIGN AND METHODS: An online questionnaire was administered to a purposive sample of 316 Australian synthetic cannabinoid users [96% cannabis users, 77% male, ...
Claramunt Rafael - - 2012
The mechanical behavior of calf pericardium, a biomaterial utilized in the manufacture of cardiac bioprostheses, in response to a short tensile cyclic test has been evaluated. The trial involved 120 samples cut longitudinally or transversely, subjected to 10 cycles until a stress of between 1 and 3 MPa was reached. Tests ...
Walker Mark S - - 2012
Abstract Objective: In this retrospective observational study, we describe treatment patterns and longitudinal health related quality of life (HRQOL) among metastatic breast cancer patients with bone metastasis from 9 community oncology clinics. Methods: For description of treatment patterns, patients were classified as treated if they started zoledronic acid within 60 ...
Zhu Hui - - 2012
Poly(o-phenylenediamine) (POPD)-derived functional carbon materials with excellent capacitive performance are successfully synthesized by means of an integrated one-step process, in which FeCl(3) not only oxidizes the polymerization of the organic monomers but also activates the carbonization. Furthermore, extensive research has proved that this strategy to discover novel carbons is useful ...
Zhang H - - 2012
The establishment of equine pregnancy is a unique and long process during which a series of physical and possibly biochemical interactions are required between the conceptus and uterus. In this study, we investigated the expression pattern of inhibin/activin subunits in the uterus during early pregnancy. The uteri from four adult ...
Lu Lee-Jane W - - 2012
Women with mostly mammographically dense fibroglandular tissue (breast density, BD) have a four- to six-fold increased risk for breast cancer compared to women with little BD. BD is most frequently estimated from two-dimensional (2D) views of mammograms by a histogram segmentation approach (HSM) and more recently by a mathematical algorithm ...
Ishida Naoki - - 2012
A rhodium catalyst induced ring opening of benzocyclobutenols with selective cleavage of the C(sp2)-C(sp3) bond adjacent to the hydroxyl group. The site-selectivity markedly contrasted with that of their thermal ring-opening reaction. The rhodium-catalyzed ring opening led to the development of a new alkyne insertion reaction construct-ing a dihydronaphthalene framework.
Vedantam A - - 2012
Study design:Case report.Objective:To demonstrate the utility of diffusion tensor imaging (DTI) and tractography in two patients with Brown-Sequard syndrome after penetrating cervical cord injury.Setting:Milwaukee, WI, USA.Methods:Two patients, who presented with features of Brown-Sequard syndrome after sustaining stab wounds to the neck, underwent DTI and tractography of the cervical cord within ...
Lesch Bluma J - - 2012
The germ line represents a continuous cellular link between generations and between species, but the germ cells themselves develop in a specialized, organism-specific context. The model organisms Caenorhabditis elegans, Drosophila melanogaster and the mouse display striking similarities, as well as major differences, in the means by which they control germ ...
Zhu Hongying H Electrical Engineering Department, University of California, Los Angeles, CA 90095, - - 2013
Improving access to effective and affordable healthcare has long been a global endeavor. In this quest, the development of cost-effective and easy-to-use medical testing equipment that enables rapid and accurate diagnosis is essential to reduce the time and costs associated with healthcare services. To this end, point-of-care (POC) diagnostics plays ...
Mfecane Sakhumzi - - 2012
This paper describes challenges that men living with HIV experience in negotiating condom use with sexual partners. After testing HIV-positive, the men in this study attended support groups of people living with HIV. Here they were taught to behave 'responsibly' by adopting safer sex measures. However, some men faced strong ...
Fu Mei R MR New York University College of Nursing, New York, NY 10003, USA. - - 2013
This systematic review aimed to evaluate the level of evidence of contemporary peer-reviewed literature published from 2004 to 2011 on the psychosocial impact of lymphedema. Eleven electronic databases were searched and 1311 articles retrieved; 23 met inclusion criteria. Twelve articles utilized qualitative methodology and 11 used quantitative methodology. An established ...
Hammer M B - - 2012
BACKGROUND: Autosomal recessive cerebellar ataxia (ARCA) comprises a large and heterogeneous group of neurodegenerative disorders. We studied three families diagnosed with ARCA. METHODS: To determine the gene lesions responsible for their disorders, we performed high-density single-nucleotide polymorphism genotyping and exome sequencing. RESULTS: We identified a new mutation in the SACS ...
Kim Jin-Sun - - 2012
Aims and objectives.  The aim of this study was to test the initial psychometric properties of the Emotional Reactions Instrument-English with hospitalised American children, ages 7-12 years, in the USA. Background.  Children's negative emotional responses have been a subject of concern for paediatric clinicians and researchers, especially because negative emotional responses ...
Timoshkin Alexey Y - - 2012
Lewis acidity trends of aluminum and gallium halides have been considered on the basis of joint X-ray and density functional theory studies. Structures of complexes of heavier group 13 element trihalides MX(3) (M = Al, Ga; X = Cl, Br, I) with monodentate nitrogen-containing donors Py, pip, and NEt(3) as ...
Farrow Sheelagh - - 2012
Abstract Objective: The requirement for formal Continuing Medical Education (CME) is growing in Europe with a concomitant focus on quality and independence of medical educational programmes together with a need for measurable effects on patient outcomes. However, during this rapid evolution, it has become clear that there are misunderstandings and ...
Frankel H L - - 2012
This Ludwig Guttmann Lecture was presented at the 2012 meeting of the International Spinal Cord Society in London. It describes the contribution of Stoke Mandeville Hospital to the field of spinal cord injuries. Dr Ludwig Guttmann started the Spinal Unit at Stoke Mandeville Hospital in 1944 and introduced a novel, ...
Mas Salvador - - 2012
Chenopodiaceae pollens such as those from Salsola kali and Chenopodium album are important causes of allergy in Mediterranean areas because of the progress of desertification in European countries. Among the different allergenic protein families, profilins constitute a group of panallergens involved in polysensitization and pollen-food allergy syndrome. Two-dimensional electrophoresis analysis ...
Loughran Jonathan - - 2012
An investigation into the effect of clinical ultrasound exposure on adherent microbubbles is described. A flow phantom was constructed in which targeted microbubbles were attached using biotin-streptavidin linkages. Microbubbles were insonated by broadband imaging pulses (centred at 2.25 MHz) over a range of pressures (peak negative pressure (PNP) = 60-375 kPa). ...
Gião Maria S - - 2012
AIMS: To calculate the shear stress needed to remove sessile Listeria monocytogenes cells from stainless steel (SS) and polytetrafluoroethylene (PTFE) surfaces. METHODS AND RESULTS: L. monocytogenes biofilms were formed on SS and PTFE surfaces. Shear stress was calculated using a radial flow chamber device and cells quantified by staining with ...
Jiao J - - 2012
Early life exposure to specific environmental factors can increase risk for developing psychopathology including major depression in adulthood. However, the molecular pathways and epigenetic mechanisms that mediate the effects of early environments on adult mood remain poorly understood. We examined the effects of different gestational and rearing conditions on adult ...
Dooley-Hash Suzanne - - 2012
OBJECTIVE: This study describes patterns of emergency department (ED) utilization by patients who screen positive for eating disorders. METHOD: ED patients aged 14-20 years (n = 1,920) completed a computerized questionnaire. The analyses compared the rates of ED use between patients who screened positive for an eating disorder and those ...
Foti Cuzzola V - - 2012
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of central nervous system comprising several subtypes. Pharmacological treatment involves only few drugs. Among these, interferon beta (IFN-β) and glatiramer acetate were the most used. Although evidence supports the efficacy of these agents in treating MS symptoms, actual studies allowed to ...
Mungalpara Jignesh - - 2012
In the absence of an experimentally determined binding mode for the cyclopentapeptide CXCR4 antagonists, we have rationally designed conformationally constrained analogs to further probe the small peptide binding pocket of CXCR4. Two different rigidification strategies were employed, both resulting in highly potent ligands (compounds 9 and 13). The information provided ...
Zhang Ying - - 2012
OBJECTIVE: The purpose of our report is to evaluate the use of color Doppler echocardiography (CDE) with four chamber view (4CV), scanning around left atrium, and four-dimensional echocardiography with B-flow imaging and spatiotemporal image correlation (4D BF-STIC) in detecting fetal pulmonary veins at 17 to 40 weeks' gestation. METHODS: This was ...
Saeidi N N Center for Engineering in Medicine, Massachusetts General Hospital and Shriners Hospital for Children, Harvard Medical School, Boston, MA, - - 2012
All available treatments directed towards obesity and obesity-related complications are associated with suboptimal effectiveness/invasiveness ratios. Pharmacological, behavioral and lifestyle modification treatments are the least invasive, but also the least effective options, leading to modest weight loss that is difficult to maintain long-term. Gastrointestinal weight loss surgery (GIWLS) is the most ...
Locatelli Bruno G BG 1st Service of Anesthesia and Intensive Care, Ospedali Riuniti di Bergamo, Bergamo, - - 2013
This randomized control trial was designed to evaluate the incidence of emergence delirium (ED) in preschool children receiving sevoflurane or desflurane anesthesia combined with an effective caudal block. While ED has been described in children receiving sevoflurane or desflurane anesthesia, a direct comparison between the two agents using a validated ...
Szekeres A - - 2012
Fumonisin B1 (FB1) is a highly toxic mycotoxin produced by fungal strains belonging to the Fusarium genus, which can be found mainly in maize products, and is gaining interest in food safety. To produce large amounts of pure FB1, a novel purifying method was developed by using centrifugal partition chromatography, ...
Samuel Edward R - - 2012
Cytomegalovirus (CMV) infections post-haematopoietic stem cell transplantation (HSCT) can be effectively controlled through the adoptive transfer of donor-derived CMV-specific T cells (CMV-T). Current strategies involve a second leukapheresis collection from the original donor to manufacture CMV-T, which is often not possible in the unrelated donor setting. To overcome these limitations ...
Loots Leigh - - 2012
A second polymorphic form of a 1 : 2 : 3 pamoate : DABCO : water salt has been obtained by liquid-assisted grinding, and it is shown that interconversion between this salt and a salt with 1 : 1 : 2 stoichiometry is facile via liquid-assisted grinding with additional amounts of pamoic acid (to generate the 1 : 1 : 2 salt) or DABCO (to generate ...
Ascherio Alberto - - 2012
Although strong genetic determinants of multiple sclerosis (MS) exist, the findings of migration studies support a role for environmental factors in this disease. Through rigorous epidemiological investigation, Epstein-Barr virus infection, vitamin D nutrition and cigarette smoking have been identified as likely causal factors in MS. In this Review, the strength ...
Gao Xiang - - 2012
Encapsulation of hydrophobic agents in polymer micelles can improve the water solubility of cargos, contributing to develop novel drugs. Quercetin (QU) is a hydrophobic agent with potential anticancer activity. In this work, we encapsulated QU into biodegradable monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles and tried to provide proof-of-principle for treating ovarian ...
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