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Wang Huaying - - 2012
BACKGROUND: Recent studies have revealed that autoimmune responses mediated by CD4(+) T cells may contribute to the development of chronic obstructive pulmonary disease (COPD). Meanwhile, imbalance of Th17/Treg has been reported to play a key role in the pathogenesis of autoimmune diseases. However, information on Th17/Treg balance in COPD is ...
Lim Chun Shen - - 2012
BACKGROUND: Because blocking agent occupies most binding surface of a solid phase, its ability to prevent nonspecific binding determines the signal-to-noise ratio (SNR) and reliability of an enzyme-linked immunosorbent assay (ELISA). METHODS: We demonstrate a stepwise approach to seek a compatible blocking buffer for indirect ELISA, via a case-control study ...
Grine Frederick E - - 2012
The human fossils, artefacts and faunal remains from the Middle Stone Age (MSA) deposits of Klasies River Main Site have featured prominently in discussions of the evolution of modern human morphology and the emergence of human behavioral modernity. Nearly 40 human fossils were uncovered by John Wymer's (1967-1968) excavations, and ...
Price Ric N - - 2012
In this review we present recent developments in the analysis of Plasmodium vivax clinical trials and ex vivo drug-susceptibility assays, as well approaches currently being used to identify molecular markers of drug resistance. Clinical trials incorporating the measurement of in vivo drug concentrations and parasite clearance times are needed to ...
Matarrese Paola - - 2012
Gut dysmotility develops in individuals during and after recovering from infective acute gastroenteritis and it is apparently due to a direct effect of circulating lipopolysaccharide (LPS). This is an endotoxin with a pro-oxidant activity derived from Gram-negative bacteria. Due to the lack of human models available so far, the mechanisms ...
García Vicente A M - - 2012
Richter's syndrome (RS) refers to transformation of the chronic lymphoid leukemia (CLL) to a diffuse large cell lymphoma. Prognosis of patients with RS is generally considered unfavorable. We present two cases of patients with history of CLL, who had an increased of the lymphadenopathy, with elevated lactate dehydrogenase (LDH) in ...
Bahuleyan Biji - - 2012
OBJECTIVE: The microsurgical anatomy of the temporal region has been well-described. However, there is a paucity of information about the transventricular endoscopic anatomy of the mesial temporal lobe and little is known about endoscopic approaches to this region. In this report, we describe the technique of endoscopic amygdalohippocampectomy. The endoscopic ...
Noble Denis - - 2012
This article explores the relativistic principle that there is no privileged scale of causality in biology to clarify the relationships between genomes and phenotypes. The idea that genetic causes are primary views the genome as a program. Initially, that view was vindicated by the discovery of mutations and knockouts that ...
Seok Hyun - - 2012
OBJECTIVE: Local corticosteroid (CS) injection has been widely used to treat carpal tunnel syndrome, but its invasiveness can cause several complications. In this study, the authors tested the efficacy of a new treatment method, extracorporeal shock wave therapy (ESWT), compared with CS injection. DESIGN: The authors carried out a randomized ...
Ke Cherng-Jyh - - 2012
Chemotherapy research highly prioritizes overcoming the multi-drug resistance (MDR) effect in cancer cells. To overcome the drug efflux mediated by P-glycoprotein (P-gp) transporters, we developed pH-responsive poly(D,L-lactic-co-glycolic acid) hollow particles (PLGA HPs), capable of delivering doxorubicin (DOX) into MDR cells (MCF-7/ADR). The shell wall of PLGA HPs contained DiO (a ...
Wang Xiang - - 2012
OBJECTIVE: To evaluate the prevalence of high-risk HPV types among female sex workers and the general population in Huzhou, China. METHODS: Cervical samples from the general population (n=292) and female sex workers (n=288) in Huzhou, China, were collected between April, 2008, and October, 2009. Demographic, behavioral, and clinical data were ...
Lin Yingsong - - 2012
We aimed to examine the association between BMI and the risk of death from pancreas cancer in a pooled analysis of data from the Asia Cohort Consortium. The data for this pooled analysis included 883 529 men and women from 16 cohort studies in Asian countries. Cox proportional-hazards models were ...
Philipponnet C - - 2012
PURPOSE: The impact of a contributive result of kidney biopsy on the management of patients in the intensive care unit (ICU) has not been extensively investigated. METHODS: Retrospective study conducted between 2000 and 2011 in five French ICUs. 56 patients who had at least one non renal organ failure, as ...
Akhteruzzaman Sharif - - 2012
Allele frequencies and forensic efficiency parameters of 11 non-standard autosomal STR loci, D21S1437, D22S683, D8S1110, D10S2325, D12S1090, D17S1294, D3S1744, D14S608, D20S470, D18S536 and D13S765 were evaluated in a sample of 102 unrelated Bangladeshi individuals. No significant deviation from Hardy-Weinberg equilibrium was observed in any of the loci studied. Statistical parameters ...
Pérez-Villares J M - - 2012
OBJECTIVE: To present the preliminary results of a non-heart beating donor (NHBD) program in a city of under 500,000 inhabitants. DESIGN: A prospective observational study was conducted between 2010 and 2011. SETTING: Virgen de las Nieves Hospital and metropolitan area of Granada (Spain). POPULATION: NHBD and brain dead donors (BDD) ...
Masden Derek L - - 2012
PURPOSE: To conduct a systematic review of literature evaluating efficacy of venous and arterial grafts for distal upper extremity bypass surgery. METHODS: A PubMed search using MeSH terms "veins/surgery" OR "arteries/surgery" AND "radial artery/surgery" OR "ulnar artery/surgery" yielded 794 studies. Manual review produced 42 studies based on inclusion criteria of ...
Ganguly Indrajit - - 2012
Mature spermatozoa contain thousands of mRNA transcripts. These untranslated mRNA may perhaps serve as a "footprint" of spermatogenesis since many of them might directly or indirectly be involved in fertilization, early embryo cleavage, poor semen quality and fertility. In this study, we tried to isolate high-quality RNA from mature spermatozoa ...
Jary F - - 2012
INTRODUCTION: The excessive and inappropriate use of carbapenems is responsible for the development of resistance. The scientific community has been requiring caution and using these agents in specific cases only. OBJECTIVES: The authors had for aim to evaluate the appropriate use of carbapenems in a French university hospital. DESIGN: A ...
Wakasa Yuhya - - 2012
Thioredoxin h (TRX h) functions as a reducing protein and is present in all organisms. As a new approach for inducing the endoplasmic reticulum (ER) stress, TRX h (OsTRX23) was expressed as a secretory protein using the endosperm-specific glutelin GluB-1 promoter and a signal peptide. In transgenic rice seeds, the ...
Lee Kyoung-Hee - - 2012
Alarmins, the endogenous molecules that recruit and activate innate immune cells, are considered as subgroups of damage-associated molecular patterns. Heat shock protein 70 (Hsp70) is one of putative alarmins together with high mobility group box 1, S100s, interleukin-1α, and annexins. It has cytokine-like functions as well as molecular chaperone functions. ...
Perroud Nader - - 2012
BACKGROUND: Personality traits have been suggested as possible risk factors for suicidal behaviours. Cloninger's model of personality (TCI), given its neurobiological background, might provide an ideal tool for the identification of dimensions associated with suicide attempt. METHODS: A number of 1333 suicide attempters and 589 non-suicide attempters suffering from different ...
Malghem Jacques - - 2012
Necrotizing fasciitis is a rare, rapidly spreading, deep-seated infection causing thrombosis of the blood vessels located in the fascia. Necrotizing fasciitis is a surgical emergency. The diagnosis typically relies on clinical findings of severe sepsis and intense pain, although subacute forms may be difficult to recognize. Imaging studies can help ...
Dorandeu Frederic - - 2012
Organophosphorus nerve agents (NA), potent irreversible cholinesterase inhibitors, could induce severe seizures, status epilepticus (SE), seizure-related brain damage (SRBD) and lethality. Despite the lack of data in the case of NA, clinical evidences suggest that SE survivors could suffer from neurological / cognitive deficits and impairments such as spontaneous recurrent ...
Tanaka Makoto - - 2012
Elderly people often develop sleep and autonomic dysfunctions, which are regulated by circadian rhythm. Recently, we reported on the degradation of neural output from the central circadian clock in the suprachiasmatic nucleus (SCN) with aging. However, it is likely that many other factors contribute to the age-related decline in the ...
Cain Mary E - - 2012
Differential rearing decreases psychostimulant-induced hyperactivity. In general, environmental enrichment decreases the locomotor response to low unit doses of psychostimuluants, whereas isolation increases the response. It is not clear whether the changes in locomotor activity are due to an enrichment-induced decrease or an isolation-induced increase. Therefore, the current experiments examined the ...
Monshausen Gabriele B - - 2012
Ca(2+) is a key player in an astonishing variety of plant signal transduction pathways where transient, spiking or oscillatory changes in cytosolic Ca(2+) levels help to couple environmental or developmental cues to appropriate cellular responses. Understanding whether and how much Ca(2+) signaling contributes to defining stimulus-response specificity has long been ...
Yamamoto Kristie Aimi - - 2012
Agaricus brasiliensis is an edible mushroom, traditionally used for the treatment of several diseases. In this paper, a polysaccharide (PLS) from A. brasiliensis, its carboxymethylated (CPLS) and sulfated (SPLS) derivatives, as well as, fractions (F1-F3) obtained from the PLS were investigated for their effect in the replication of herpes simplex ...
Valverde Guilherme B - - 2012
OBJECTIVES: 1) To chemically characterize Y-TZP surface via X-ray photoelectron spectroscopy (XPS) and evaluate the surface energy levels (SE) after non-thermal plasma (NTP). 2) To test the microtensile bond strength (MTBS) of Y-TZP bonded to cured composite disks, after a combination of different surface conditioning methods. METHODS: Twenty-four Y-TZP discs ...
Hong Paul - - 2012
OBJECTIVE: To perform a contemporary review of experimental studies to describe the effects of various novel adjuvant therapies in enhancing tympanic membrane (TM) perforation healing. METHODS: A PubMed search for articles from January 2000 to June 2012 related to TM perforation, along with the references of those articles, was performed. ...
Magnolo Lucia - - 2012
Monogenic hypobetalipoproteinemias include three disorders: Abetalipoproteinemia (ABL) and Chylomicron Retention Disease (CMRD) with recessive transmission and Familial Hypobetalipoproteinemia (FHBL) with dominant transmission. We investigated three unrelated Tunisian children born from consanguineous marriages, presenting hypobetalipoproteinemia associated with chronic diarrhea and retarded growth. Proband HBL-108 had a moderate hypobetalipoproteinemia, apparently transmitted as ...
Dhanda Saurabh - - 2012
Oxidative stress caused by ammonia toxicity is known to play a key role in the pathogenesis of hepatic encephalopathy (HE). The present study was designed to evaluate the protective effect of N-acetyl-L-cysteine (NAC) supplementation in bile duct ligation (BDL)-induced model of HE. Three weeks after BDL, rats developed biliary fibrosis ...
Mediavilla José R - - 2012
During the 1990s, various reports of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections appeared in the literature, caused by novel strains genetically distinct from traditional healthcare-associated MRSA (HA-MRSA). Numerous lineages of CA-MRSA have since emerged on every continent, several of which have spread internationally, most notably USA300. CA-MRSA strains are increasingly ...
Wibaut B - - 2012
Although transfusion practices have changed these last years, the neonatal period remains one period when the transfusion of blood components (in particular in red blood cells concentrates) is frequent, particularly for low birth weight premature babies. It is thus important to know well the pathophysiological characteristics specific to this age ...
Gu Yapeng - - 2012
Epithelia use a unique process called 'cell extrusion' to remove cells from a layer, while preserving their barrier function. Specifically, a cell destined to die triggers formation of an actin and myosin-ring in the live neighboring epithelial cells surrounding it, which squeeze the dying cell out. During extrusion, the surrounding ...
Smith Justin S JS Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia. Electronic address: - - 2013
To present operative details and clinical follow-up of a series of patients with thoracic disk herniation treated with the minimally invasive technique of thoracic microendoscopic diskectomy (TMED). TMED was performed in 16 consecutive patients (age range, 18-79 years old) with 18 thoracic disk herniations. One patient with a calcified herniation ...
Shen Chun-Mei - - 2012
Population genetic data of 21 autosomal short tandem repeats (STRs) were obtained in a sample of 106 unrelated healthy individuals of Bai ethnic minority born in the Dali Bai Autonomous Prefecture in Yunnan Province. We observed 138 alleles with corresponding allelic frequencies ranging from 0.005 to 0.575. The genotypic frequency ...
Locatelli Y - - 2012
In mammals, recovery of oocytes by laparoscopic ovum pick-up (LOPU) coupled with in vitro production (IVP) of embryos represents a promising strategy for both amplification and genetic management of sparse animals from captive endangered wild species. As integrated technique developed mainly for domestic livestock, LOPU-IVP requires several studies to set ...
Carvalho Fabiano B - - 2012
AIMS: We investigated whether the treatment with anthocyanins prevents the scopolamine-induced memory deficits and whether ectonucleotidases activities and purines levels are altered in the cerebral cortex (CC) and hippocampus (HC) in this model of mnemonic deficit in rats. MAIN METHODS: The animals were divided into 4 experimental groups: control (vehicle), ...
Roelen C A M - - 2012
BACKGROUND: Sickness absence is high in healthcare and contributes to nursing staff shortages reducing the efficiency and quality of patient care. Assessing the risk of sickness absence in working nurses opens opportunities for preventive strategies. Job satisfaction has attracted much attention in healthcare research and has been associated with sickness ...
Pazi Idil - - 2012
The residual levels of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were determined in surface sediments collected from Candarli Gulf. Total concentrations of OCPs and PCBs in sediments ranged from 10.2 to 57.3 and 2.8 to 205ngg(-1)dwt, respectively. DDTs in sediments were derived from the aged and weathered agricultural soils ...
Albuquerque Felipe C - - 2012
OBJECTIVE: We described our endovascular techniques for recanalization of chronic occlusions of the brachiocephalic and subclavian arteries. Given their large caliber, origins from the aorta, and proximity to the carotid and vertebral arteries, various complex endovascular techniques are required to achieve revascularization. Navigation of distal embolic protection devices into the ...
Wang Michael Y - - 2012
Minimally invasive spinal surgery (MIS) has many favorable attributes that would be of great benefit to patients with an adult spinal deformity. Decreased blood loss, lower infection rates, and faster mobilization may help to reduce the high rate of complications associated with these interventions. While correction of coronal deformity has ...
Criscuolo-Urbinati E - - 2012
Based on the reports of unsuccessful ovulation in pacu (Piaractus mesopotamicus) by fish farmers and researchers undertaking artificial reproduction programs, we evaluated the use of prostaglandin F (PGF) to improve pacu ovulation. This study was conducted during two spawning seasons (2009/2010 and 2010/2011) with two samplings in the first season ...
Köchel Angelika - - 2012
Boys afflicted with ADHD (Attention-deficit/hyperactivity disorder) are characterized by deficient response inhibition and reduced electrocortical late positivity when presented with facial expressions of anger. This deficit might contribute to their problems in social interactions. We conducted the present event-related potential study with 15 men suffering from ADHD and 15 healthy ...
Boudin Eveline - - 2012
Sclerosing bone dysplasias are a heterogeneous group of rare diseases marked by increased BMD caused by either increased bone formation or by decreased bone resorption. In this study we have focused on craniotubular hyperostoses mainly affecting the long bones and the skull. Currently, there are three causative genes identified namely ...
Zavaglia Claudio - - 2012
AIMS: The aim of this study was to assess the safety and efficacy of sorafenib, with or without everolimus, in the treatment of recurrent hepatocellular carcinoma (HCC) after an orthotopic liver transplantation (OLT). METHODS: We reviewed the outcome of our consecutive cohort series of patients. Eleven patients (nine men) with ...
Grzesiak M - - 2012
Recent studies suggest that disturbed androgen action during gestational and neonatal periods leads to reprogramming of the trajectory of ovarian development, manifested by altered follicular functioning in adulthood. In this study, we tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17β-estradiol (E(2)) synthesis and the associated gene ...
Messer Insa - - 2012
BACKGROUND: Double-balloon enteroscopy (DBE) is an established method in diagnostic and therapeutic small-bowel enteroscopy. OBJECTIVE: Spiral enteroscopy (SE) appears to be a promising new technique. A randomized, prospective study was conducted to compare both methods. DESIGN: Randomized, prospective study. SETTING: Single tertiary referral center. PATIENTS: Between September 2009 and March ...
Naclerio Fernando - - 2012
ABSTRACT:: The aim of this study was to compare the effects of 3 different volume of resistance training (RT) on maximum strength and average power in college team sport athletes with no previous resistance training experience. 32 subjects (20 men and 12 women, age = 23.1± 1.57 yrs) were randomly ...
Johansson Daniel - - 2012
Infective endocarditis (IE) is a severe infection associated with significant morbidity and mortality. Enterococcus faecalis is among the most common causes of this disease, and yet little is known about the pathogenesis of E. faecalis IE. We screened 21 E. faecalis isolates from IE and 21 isolates from normal flora ...
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