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Baur Xaver - - 2012
BACKGROUND: Airborne enzymes behave as potent respiratory allergens. Till date, allergic disorders caused by genetically engineered enzymes widely used in the industry, have not been reported. RESULTS AND CONCLUSIONS: We describe a worker employed in the detergent industry who developed asthma and rhinitis from IgE-mediated sensitization to the thermostable endo-alpha-amylase ...
Barry Caswell C UCL Institutes of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom. caswell.barry@ucl.ac.uk - - 2012
The hippocampal formation plays key roles in representing an animal's location and in detecting environmental novelty to create or update those representations. However, the mechanisms behind this latter function are unclear. Here, we show that environmental novelty causes the spatial firing patterns of grid cells to expand in scale and ...
Kaehr Bryan B Advanced Materials Laboratory, Sandia National Laboratories, Albuquerque, NM 87106, USA. - - 2012
Tissue-derived cultured cells exhibit a remarkable range of morphological features in vitro, depending on phenotypic expression and environmental interactions. Translation of these cellular architectures into inorganic materials would provide routes to generate hierarchical nanomaterials with stabilized structures and functions. Here, we describe the fabrication of cell/silica composites (CSCs) and their ...
Fridman Gene Y GY Department of Otolaryngology-Head & Neck surgery, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA. - - 2012
This article reviews vestibular pathology and the requirements and progress made in the design and construction of a vestibular prosthesis. Bilateral loss of vestibular sensation is disabling. When vestibular hair cells are injured by ototoxic medications or other insults to the labyrinth, the resulting loss of sensory input disrupts vestibulo-ocular ...
Sahly Iman - - 2012
The mechanisms underlying retinal dystrophy in Usher syndrome type I (USH1) remain unknown because mutant mice lacking any of the USH1 proteins-myosin VIIa, harmonin, cadherin-23, protocadherin-15, sans-do not display retinal degeneration. We found here that, in macaque photoreceptor cells, all USH1 proteins colocalized at membrane interfaces (i) between the inner ...
Bao Wenzhong - - 2012
Graphene is nature's thinnest elastic membrane, and its morphology has important impacts on its electrical, mechanical and electromechanical properties. Here we report manipulation of the morphology of suspended graphene via electrostatic and thermal control. By measuring the out-of-plane deflection as function of applied gate voltage and number of layers, we ...
Do Diana V - - 2012
OBJECTIVE To assess the benefit of increased follow-up and treatment with ranibizumab between months 24 and 36 in the Ranibizumab for Edema of the Macula in Diabetes (READ-2) Study. DESIGN Prospective, interventional, multicenter follow-up of a randomized clinical trial. METHODS Patients who agreed to participate between months 24 and 36 ...
Mun Sue Jean - - 2012
BACKGROUND: The conventional escalation regimen for sublingual immunotherapy (SLIT) in patients with allergic rhinitis has been proven to be safe and successful in reducing allergic symptoms. However, few studies compared the efficacy and safety between a conventional escalation regimen for SLIT and once-daily SLIT. The aim of the present study ...
Sambroni Elisabeth - - 2012
The general rules established from mammalian species for the regulation of spermatogenesis by gonadotropins may not be fully relevant in fish. Particularly, Fsh is as potent as Lh to stimulate steroidogenesis and the Fsh receptor is expressed in the Leydig cells. In seasonal breeders, Fsh is likely the major gonadotropin ...
Hadders Michael A MA Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 0QH, United - - 2012
The endosomal sorting complexes required for transport (ESCRT) proteins have a critical function in abscission, the final separation of the daughter cells during cytokinesis. Here, we describe the structure and function of a previously uncharacterized ESCRT-III interacting protein, MIT-domain containing protein 1 (MITD1). Crystal structures of MITD1 reveal a dimer, ...
Duerkop Breck A - - 2012
The mammalian intestine is home to a dense community of bacteria and its associated bacteriophage (phage). Virtually nothing is known about how phages impact the establishment and maintenance of resident bacterial communities in the intestine. Here, we examine the phages harbored by Enterococcus faecalis, a commensal of the human intestine. ...
So Kazutaka - - 2012
Cementless total hip arthroplasty is currently favored by many orthopedic surgeons. The design of the porous surface is critically important for long-term fixation. We examined the clinical and radiographic outcome of the cementless titanium hip implant with a bottom coating of apatite-wollastonite containing bioactive glass ceramic. We retrospectively reviewed 109 ...
Wynne Joseph P JP Cancer Institute, NYU School of Medicine, New York, NY 10016, - - 2012
Adaptive immunity depends on lymphocyte adhesion that is mediated by the integrin lymphocyte functional antigen 1 (LFA-1). The small guanosine triphosphatase Rap1 regulates LFA-1 adhesiveness through one of its effectors, Rap1-interacting adapter molecule (RIAM). We show that RIAM was recruited to the lymphocyte plasma membrane (PM) through its Ras association ...
Shi Haibin - - 2012
Real-time monitoring of cell apoptosis could provide valuable insights into early detection of therapy efficiency and evaluation of disease progression. In this work, we designed and synthesized a new live-cell permeable, fluorescent light-up probe for real-time cell apoptosis imaging. The probe is comprised of a hydrophilic caspase-specific Asp-Glu-Val-Asp (DEVD) peptide ...
Blasco Salvador - - 2012
The crystal structure of a binuclear Mn(III) complex of a scorpiand-like ligand (L) displays an unsupported single oxo bridging ligand with a Mn(III)-O-Mn(III) angle of 174.7°. Magnetic susceptibility measurements indicate strong antiferromagnetic coupling between the two metal centers. DFT calculations have been carried out to understand the magnetic behavior and ...
Bakker E R M - - 2012
Apc-driven tumor formation in patients and Apc-mutant mouse models is generally attributed to increased levels of β-catenin signaling. We and others have proposed that a specific level of β-catenin signaling is required to successfully initiate tumor formation, and that each tissue prefers different dosages of signaling. This is illustrated by ...
Keric Naureen - - 2012
Background We report the rare case of an adult transsphenoidal meningoencephalocele and outline the microneurosurgical strategy. Clinical history, the findings of computerized tomography (CT) scans and magnetic resonance imaging (MRI), the microsurgical procedure, and histopathology are reported.Case Report A 54-year-old female patient complained about cerebrospinal fluid (CSF) rhinorrhea; a transnasal biopsy of ...
Budenz Cameron L CL Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109, - - 2012
Severe to profound deafness is most often secondary to a loss of or injury to cochlear mechanosensory cells, and there is often an associated loss of the peripheral auditory neural structures, specifically the spiral ganglion neurons and peripheral auditory fibers. Cochlear implantation is currently our best hearing rehabilitation strategy for ...
Pinedo M - - 2012
Several apoplastic enzymes have been implicated in the control of elongation growth of plant cells. Among them, peroxidases contribute to both loosening and stiffening of the cell wall. They appear to be regulated by various mechanisms, including the action of extracellular inhibitors. To obtain evidence of the role of the ...
Hertzman Clyde - - 2012
This paper describes evidence that led to the concept of biological embedding and research approaches designed to elucidates its mechanisms. Biological embedding occurs when experience gets under the skin and alters human biological and developmental processes; when systematic differences in experience in different social environments in society lead to systematically ...
Hansen Wiebke - - 2012
Infiltration of Foxp3(+) regulatory T (T reg) cells is considered to be a critical step during tumor development and progression. T reg cells supposedly suppress locally an effective anti-tumor immune response within tumor tissues, although the precise mechanism by which T reg cells infiltrate the tumor is still unclear. We ...
Dummer Reinhard - - 2012
PURPOSEMycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma. There is a need for multicenter trials involving defined patient populations using rigorous assessment criteria. We have investigated pegylated liposomal doxorubicin (PLD) in a clearly defined patient population with advanced MF. PATIENTS AND METHODSEligible patients had stage IIB, IVA, ...
van Beers Joyce J B C - - 2012
OBJECTIVE: This study aimed to generate a catalog of citrullinated proteins present in the synovia of rheumatoid arthritis (RA) patients and to elucidate their relevance for the anti-citrullinated protein antibody response in RA. METHODS: Polypeptides isolated from RA patient synovial fluid were identified by mass spectrometry. Three proteins (apolipoprotein E, ...
Warren-Gash Charlotte - - 2012
Please cite this paper as: Warren-Gash et al. (2012) Hand hygiene to reduce community transmission of influenza and acute respiratory tract infection: a systematic review. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12015. Hand hygiene may be associated with modest protection against some acute respiratory tract infections, but its specific role in ...
Lau Wei Ling WL Department of Nephrology, University of Washington, Seattle, WA, - - 2013
Chronic kidney disease-mineral bone disorder (CKD-MBD) is a systemic syndrome characterized by imbalances in mineral homeostasis, renal osteodystrophy (ROD) and ectopic calcification. The mechanisms underlying this syndrome in individuals with chronic kidney disease (CKD) are not yet clear. We examined the effect of normal phosphate (NP) or high phosphate (HP) ...
Rask-Andersen Helge - - 2012
This is a review of the anatomical characteristics of human cochlea and the importance of variations in this anatomy to the process of cochlear implantation (CI). Studies of the human cochlea are essential to better comprehend the physiology and pathology of man's hearing. The human cochlea is difficult to explore ...
Han Ying - - 2012
Triptycene-based macrotricyclic host containing two dibenzo-30-crown-10 moieties could form ladder-like supramolecular poly[3]pseudorotaxanes with π-extended viologens in both high concentration solution and solid state.
Sharma Punit - - 2012
ABSTRACT The purpose of this study was to evaluate the role of 18F-Fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) for detecting relapse in post treatment patients of primary gastric lymphoma (PGL). Data of 39 previously treated PGL patients (Age: 50.3±13.8 years; Male: 24) who underwent 71 (18)F-FDG PET-CT for suspected ...
Wang Yan - - 2012
OBJECTIVES To develop a reliable, reproducible rat model of posterior ischemic optic neuropathy (PION) and study the cellular responses in the optic nerve and retina. METHODS Posterior ischemic optic neuropathy was induced in adult rats by photochemically induced ischemia. Retinal and optic nerve vasculature was examined by fluorescein isothiocyanate-dextran extravasation. ...
Ugur F A - - 2012
The purpose of this survey was to determine the distribution of terrestrial radionuclides ((238)U, (232)Th and (40)K) in surface soil samples collected from different locations in and around Osmaniye and assess the radiological implications of outdoor external exposure. The activity concentrations of (238)U, (232)Th and (40)K in soil samples ranged ...
Koso Hideto H Division of Genetics and Genomics, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore - - 2012
Neural stem cells (NSCs) are considered to be the cell of origin of glioblastoma multiforme (GBM). However, the genetic alterations that transform NSCs into glioma-initiating cells remain elusive. Using a unique transposon mutagenesis strategy that mutagenizes NSCs in culture, followed by additional rounds of mutagenesis to generate tumors in vivo, ...
Wu Xiangmei - - 2012
This study monitored indoor and outdoor particle concentrations in 37 small and medium commercial buildings (SMCBs) in California with three buildings sampled on two occasions, resulting in 40 sampling days. Sampled buildings included offices, retail establishments, restaurants, dental offices, and hair salons, among others. Continuous measurements were made for both ...
Durand Marianne - - 2012
OBJECTIVE.: Our objective was to compare the osteoclastogenic capacity of peripheral blood mononuclear cells (PBMCs) from patients with osteoarthritis (OA) to that of PBMCs from self-reported normal individuals. METHODS.: PBMCs from 140 patients with OA and 45 healthy donors were assayed for CD14(+) expression and induced to differentiate into osteoclasts ...
Lang Thomas - - 2012
We describe a novel kind of sensor for carbon dioxide. It is based on surface plasmon resonance (SPR) and a polymer blend that is capable of fully reversibly binding carbon dioxide. The interaction results in a change in the polarity and refractive index that can be detected via SPR. The ...
Cook Sarah E - - 2012
ABSTRACT While driving is a complex task, it becomes relatively automatic over time although unfamiliar situations require increased cognitive effort. Much research has examined driving risk in cognitively impaired elders and found little effect. This study assessed whether mildly memory impaired elders made disproportionate errors in driving or story recall, ...
Lapointe Jérôme - - 2012
Mclk1 (also known as Coq7) and Coq3 code for mitochondrial enzymes implicated in the biosynthetic pathway of ubiquinone (coenzyme Q or UQ). Mclk1(+/-) mice are long-lived but have dysfunctional mitochondria. This phenotype remains unexplained, as no changes in UQ content were observed in these mutants. By producing highly purified submitochondrial ...
Ozawa Rika - - 2012
Different organisms compensate for, and adapt to, environmental changes in different ways. In this way, environmental changes affect animal-plant interactions. In this study, we assessed the effect of temperature on a tritrophic system of the lima bean, the herbivorous spider mite Tetranychus urticae and the predatory mite Phytoseiulus persimilis. In ...
Sateriale Adam A Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, - - 2012
The parasitic protozoan Entamoeba histolytica is aptly named for its capacity to destroy host tissue. When E. histolytica trophozoites invade the lamina propria of a host colon, extracellular matrices are degraded while host cells are killed and phagocytosed. The ability of E. histolytica to phagocytose host cells correlates with virulence ...
Maayan-Metzger Ayala - - 2012
AIM: To determine perinatal parameters among term newborn infants born by vaginal delivery with meconium stained amniotic fluid (MSAF) that needed pediatrician assistance. METHODS: Pediatricians who were in attendance in the delivery room due to MSAF among term infants completed 775 reports regarding the infants' delivery conditions and the assistance ...
He Yan-Ping - - 2012
Presented here is a new porous metal-organic framework based on a nanosized tris((4-carboxyl)phenylduryl)amine ligand, which features a 2-fold interpenetrating hms network and shows distinct gas adsorption behaviors dependent on different activation methods.
Musiello Toni - - 2012
BACKGROUND: The rates of contralateral prophylactic mastectomy (CPM) are increasing worldwide. This study investigated Australian and New Zealand's breast surgeons' perceptions, knowledge and attitudes towards CPM, and explored if demographic characteristics of surgeons were associated with an increased tendency to recommend or perform CPM. METHODS: A cross sectional research design ...
Takezawa Hiroki - - 2012
An overcrowded alkene with anti-folded conformation was converted to its twisted conformer, accompanied by a dramatic color change from yellow to deep purple, by inclusion in a self-assembled T(d)-symmetric coordination cage. The shape of the caged cavity was suitable and desirable for trapping the twisted conformer. The twisted conformation was ...
Peng Wenjie - - 2012
Previous studies have demonstrated that cell wall arabinogalactan from mycobacteria possesses a single galactosamine (GalN) residue. This moiety, which is one the rare natural occurrences of galactosamine lacking an acetyl group on the nitrogen, has been identified as a pendant substituent attached to a highly branched arabinofuranose residue in the ...
Manchanda P K PK Department of Molecular, Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, - - 2013
Schwannomas are peripheral nerve sheath tumors that often occur in the setting of an inherited tumor predisposition syndrome, including neurofibromatosis types 1 (NF1) and 2 (NF2), familial schwannomatosis and Carney complex. Loss of the NF2 tumor suppressor (encoding NF2, or Merlin) is associated with upregulation of the Rac1 small GTPase, ...
Hernández-Juárez Martín - - 2012
The preparation of new Ru(ii) complexes incorporating fac-coordinated lutidine-derived CNC ligands is reported. These derivatives are selectively deprotonated by (t)BuOK at one of the methylene arms of the pincer, leading to catalytically active species in the hydrogenation of imines.
Pirona R - - 2012
The expression profile of flavour-related genes during ripening was investigated in two peach genotypes, Bolero and OroA, which have been selected for their contrasting aroma/ripening behaviour. A new peach microarray containing 4776 oligonucleotide probes corresponding to a set of ESTs specifically enriched in secondary metabolism (μPEACH2.0) was designed to investigate ...
Mashoodh Rahia - - 2012
Paternal environmental experiences are significant predictors of developmental outcomes in offspring and can occur even in the absence of paternal care. Although there has been a recent focus on the role of environmentally induced changes in the male germline in producing these effects, the potential mediating role of mothers has ...
Oakley Robert H - - 2012
G protein-coupled receptors (GPCRs) compose the largest family of cell surface receptors and are the most common target of therapeutic drugs. The nonvisual arrestins, β-arrestin-1 and β-arrestin-2, are multifunctional scaffolding proteins that play critical roles in GPCR signaling. On binding of activated GPCRs at the plasma membrane, β-arrestins terminate G ...
Ewertz Marianne - - 2012
To examine the association of baseline body mass index (BMI) with the risk of recurrence or death in postmenopausal women with early-stage breast cancer receiving adjuvant tamoxifen or letrozole in the Breast International Group (BIG) 1-98 trial at 8.7 years of median follow-up. This report analyzes 4,760 patients with breast ...
Lockley Andrew John - - 2012
We welcome the suggested methods of intervention in the methane budget detailed by Stolaroff et al. We consider available literature and technology and suggest five new techniques. We also offer additional detail on five Stolaroff techniques: drainage management; lake sealing; bubble management; ignition; & compression oxidation. The original paper frames ...
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