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Maddukuri Leena L Department of Biochemistry and Molecular Biology, The University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, - - 2012
We have investigated the interaction between human DNA polymerase η (hpol η) and the Werner syndrome protein (WRN). Functional assays revealed that the WRN exonuclease and RecQ C-terminal (RQC) domains are necessary for full stimulation of hpol η-catalyzed formation of correct base pairs. We find that WRN does not stimulate ...
Joo Hyung W - - 2012
Constraint-induced movement therapy (CIMT) is an effective treatment promoting motor recovery of upper extremity function in stroke patients. The objective of the present study was to determine the effect of CIMT on the evoked potentials in rats with focal cerebral cortical ischemia induced by endothelin-1 (ET-1). Thirty rats were randomly ...
Scott John D JD Howard Hughes Medical Institute and Department of Pharmacology, University of Washington School of Medicine, Seattle, Washington 98195, USA. - - 2013
Second messenger responses rely on where and when the enzymes that propagate these signals become active. Spatial and temporal organization of certain signaling enzymes is controlled in part by A-kinase anchoring proteins (AKAPs). This family of regulatory proteins was originally classified on the basis of their ability to compartmentalize the ...
Gifford Jayson R JR Department of Exercise Sciences, Brigham Young University, Provo, UT, USA. - - 2012
Heating skin is believed to activate vanilloid type III and IV transient receptor potential ion channels (TRPV3, TRPV4, respectively), resulting in the release of ATP into the interstitial fluid. We examined the hypothesis that local skin heating would result in an accumulation of ATP in the interstitial fluid that would ...
Bhattacharya S S Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104-4539, - - 2013
Viral and pharmacological inducers of protein kinase RNA-activated (PKR)-like ER kinase (PERK) were shown to accelerate the phosphorylation-dependent degradation of the IFNAR1 chain of the Type 1 interferon (IFN) receptor and to limit cell sensitivity to IFN. Here we report that hypoxia can elicit these effects in a PERK-dependent manner. ...
Aminkeng Folefac - - 2012
Heterozygous de-novo mutations in ATP1A3 in patients with alternating hemiplegia of childhood: a whole-exome sequencing gene-identification study. Rosewich H et al. (2012) Lancet Neurol. 2012 Sep;11(9):764-73.
Munkholm Klaus - - 2012
Munkholm K, Vinberg M, Berk M, Kessing LV. State-related alterations of gene expression in bipolar disorder: a systematic review. Bipolar Disord 2012: 00: 000-000. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objective:  Alterations in gene expression in bipolar disorder have been found in numerous ...
Kerr D M - - 2012
BACKGROUND AND PURPOSE: This study determined the effect of JZL184, a selective inhibitor of monoacylglycerol lipase (MAGL), the enzyme which preferentially catabolises the endocannabinoid 2-arachidonoyl glycerol (2-AG), on inflammatory cytokines in the brain and plasma following an acute immune challenge. The receptor and molecular mechanisms involved were also investigated. EXPERIMENTAL ...
Hwang Huei-Lih - - 2012
BACKGROUND: Until now, caring research has focused on constructs, processes and outcomes of caring traits exhibited mainly by nurses or nursing students in hospitals. Few studies have considered the perspectives of elderly residents of long-term care facilities (LTCFs). AIMS: The aim of this study was to elucidate the nature of ...
Geng Wan-Li - - 2012
Herbarone (1), a novel heptaketide with a tetrahydro-5,9-methanobenzo[8]annulen-10(5H)-one skeleton, together with the new ent-astropaquinones B (2) and C (3) and four known pyranonaphthoquinones (4-7), was isolated from the sea hare associated fungus Torula herbarum. The structures of the new compounds were elucidated by detailed spectroscopic analysis, and the absolute configurations ...
Duah Nancy O NO Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana. - - 2012
In 2005, sulphadoxine-pyrimethamine (SP) became the drug of choice for intermittent preventive treatment of Plasmodium falciparum malaria in pregnancy (IPTp) in Ghana. Reports suggest the use of SP by others to treat uncomplicated malaria. Because of the increased use of SP, the prevalence of mutations in the genes, dihydrofolate reductase ...
De Conti Laura - - 2012
One of the fundamental issues in RNA splicing research is represented by understanding how the spliceosome can successfully define exons and introns in a huge variety of pre-mRNA molecules with nucleotide-precision. Since its first description, researchers in this field have identified and characterized many fundamental elements and players capable of ...
Xi Zhenxiang - - 2012
The angiosperm order Malpighiales includes ~16,000 species and constitutes up to 40% of the understory tree diversity in tropical rain forests. Despite remarkable progress in angiosperm systematics during the last 20 y, relationships within Malpighiales remain poorly resolved, possibly owing to its rapid rise during the mid-Cretaceous. Using phylogenomic approaches, ...
Adler Nancy - - 2012
Health disparities research spans multiple fields and methods and documents strong links between social disadvantage and poor health. Associations between socioeconomic status (SES) and health are often taken as evidence for the causal impact of SES on health, but alternative explanations, including the impact of health on SES, are plausible. ...
Madhusudan Puttaswamy - - 2012
A facile template-free hydrothermal approach is developed to synthesize hierarchical flower-like graphene-Bi(2)O(2)CO(3) microcomposites. The as-prepared samples were systematically characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, Fourier transform infrared spectroscopy, N(2) adsorption-desorption and UV-visible diffuse reflectance spectroscopy. The photocatalytic activity of the as-prepared ...
Bourke Claire D - - 2012
Background. Schistosomiasis elicits cross-regulatory immune responses, but it is unclear how antihelminthic treatment affects this balance. This study integrates data on 13 cytokines elicited by 3 schistosome to examine how praziquantel treatment alters immune polarization and whether post-treatment cytokine profiles influence reinfection status.Methods. Venous blood from 72 Schistosoma haematobium-exposed participants was cultured ...
Gordon Bruce R - - 2012
BACKGROUND: Intradermal skin testing is a useful allergy diagnostic tool. Although considered safe when properly performed, systemic reactions have been reported. This is the first large, prospective study to record and evaluate all systemic reactions from intradermal skin testing (IDT) to inhalant or food antigens. METHODS: A 24-month prospective study ...
Maluenda Gabriel - - 2012
VIABAHN® endoprosthesis (Gore & Associates, Flagstaff, AZ), a nitinol self-expanding polytetrafluoroethylene (PTFE) lined stent, has demonstrated utility for percutaneous treatment of chronic occlusive disease involving the superficial femoral artery. In a case series communication we aimed to describe the feasibility of a PTFE-lined stent for percutaneous treatment of conditions other ...
Russell Bradly - - 2012
Abstract Objective: To assess changes in mandibular third molar angulation during orthodontic treatment in subjects having either first or second premolars or neither removed. Materials and Methods: In a retrospective study approved by the institutional review board, right and left mandibular third molar angulations were compared to the vertical axis ...
Minns Robert A - - 2012
BACKGROUND:Retinal hemorrhages (RHs) occur in inflicted traumatic brain injury (ITBI), accidental traumatic brain injury (ATBI), and some medical conditions, although the reported number, distribution, type, and frequency vary greatly between these different etiologies. We hypothesize that these RH characteristics reliably help to distinguish ITBI from ATBI and nontraumatic etiologies.METHODS:A 6-year ...
Hargreaves Victoria V VV Ludwig Institute for Cancer Research, Department of Medicine, Moores-University of California San Diego Cancer Center, and Institute of Genomic Medicine, University of California School of Medicine, San Diego, La Jolla, California 92093-0669, - - 2012
ATP binding causes the mispair-bound Msh2-Msh6 mismatch recognition complex to slide along the DNA away from the mismatch, and ATP is required for the mispair-dependent interaction between Msh2-Msh6 and Mlh1-Pms1. It has been inferred from these observations that ATP induces conformational changes in Msh2-Msh6; however, the nature of these conformational ...
Sperschneider Jana - - 2012
MOTIVATION: Laboratory RNA structure determination is demanding and costly and thus, computational structure prediction is an important task. Single sequence methods for RNA secondary structure prediction are limited by the accuracy of the underlying folding model. On the other hand, if a structure is supported by a family of evolutionarily ...
Jin Kyubok K Division of Nephrology and Hypertension, University of California, Irvine, Irvine, CA, - - 2013
Chronic kidney disease (CKD) results in hypertriglyceridemia which is largely due to impaired clearance of triglyceride-rich lipoproteins occasioned by downregulation of lipoprotein lipase and very low-density lipoprotein (LDL) receptor in the skeletal muscle and adipose tissue and of hepatic lipase and LDL receptor-related protein in the liver. However, data on ...
Levitzki Alexander - - 2012
With the manufacture of imatinib, researchers introduced tyrosine kinase inhibitors (TKIs) into the clinical setting in 2000 to treat cancers; approximately fifteen other TKIs soon followed. Imatinib remains the most successful agent, whereas all the others have had modest effects on the cancers that they target. The current challenge is ...
Gabriele Bartolo - - 2012
A variety of readily available 1-mercapto-3-yn-2-ols 5 were conveniently converted into the corresponding thiophenes 6 in good to high yields in MeOH as the solvent at 50-100 °C in the presence of catalytic amounts (1-2 %) of PdI2 in conjunction with KI (KI:PdI2 molar ratio = 10). The catalyst could ...
Loizzi Michele - - 2012
Subglottic haemangioma (SGH) is a rare, benign tumour in children, which is potentially life-threatening because of airway obstruction. We report the case of a full-term 2-month-old infant girl admitted to our institution with stridor, dyspnoea and oxygen desaturation caused by a SGH and treated with propranolol. Neck-chest computed tomography (CT) ...
Emmenegger B A BA Department of Pharmacology & Cancer Biology and Preston Robert Tisch Brain Tumor Center, Duke University Medical Center, Durham, NC, - - 2013
Cerebellar granule neurons are the most abundant neurons in the brain, and a critical element of the circuitry that controls motor coordination and learning. In addition, granule neuron precursors (GNPs) are thought to represent cells of origin for medulloblastoma, the most common malignant brain tumor in children. Thus, understanding the ...
Kureck Ilka M - - 2012
Inbreeding can lead to the expression of deleterious recessive alleles and to a subsequent fitness reduction. In Hymenoptera, deleterious alleles are purged in haploid males moderating inbreeding costs. However, in these haplodiploid species, inbreeding can result in the production of sterile diploid males. We investigated the effects of inbreeding on ...
Stewart Mary - - 2012
The present study reports on a new vocal emotion recognition task and assesses whether people with autism spectrum conditions (ASC) perform differently from typically developed individuals on tests of emotional identification from both the face and the voice. The new test of vocal emotion contained trials in which the vocal ...
Montalbán Itziar Aurora - - 2012
In Pinus radiata D. Don, the transition from the juvenile to the mature phase is characterized by a reduction in the tree's organogenic potential, which is usually reverted in breeding programs by reinvigoration procedures to enable vegetative propagation. In this work we have determined the best culture conditions for in ...
Chan Hsun-Liang - - 2012
PURPOSE: The degree of difficulty in performing lateral window sinus augmentation may depend on the morphology of the maxillary sinus. The aim of this was to measure the distances between the medial and lateral sinus wall (sinus width [SW]) at different levels and apply those SW values to formulate a ...
Ding Xilai - - 2012
Allogeneic hematopoietic cell transplantation is an established treatment for hematologic and nonhematologic malignancies. Donor-derived immune cells can identify and attack host tumor cells, producing a graft-versus-tumor (GVT) effect that is crucial to the effectiveness of the transplantation therapy. CBLB502 is a novel agonist for TLR5 derived from Salmonella flagellin. On ...
Schäfer Anja - - 2012
In continuation of our previous work, several 2,3,5-triarylpyrroles with chlorine or fluorine substituents in the aryl residues were synthesised and tested for estrogen receptor (ER) binding at isolated ERα/ERß receptors (HAP assay) and in transactivation assays using ERα-positive MCF-7/2a as well as U2-OS/ERα and U2-OS/ERß cells. In the competition experiment ...
Novak Iona I Cerebral Palsy Alliance Research Institute, Sydney, Australia. - - 2012
To summarize evidence on the rates of co-occurring impairments, diseases, and functional limitations with cerebral palsy into succinct clinical messages. A search was conducted of the databases PubMed, Medline, CINAHL, and PsycINFO, and the results were supplemented with hand searches. Two independent reviewers determined whether retrieved abstracts met the following ...
Bilge Yildiz Dallar - - 2012
Objective: This study aims to explore the relation between childhood obesity and procoagulant and anticoagulant systems. Method: Fifty-one obese children and 32 normal-weighted children with similar age and gender distribution and between ages of 5 and 16 years were recruited to the study. Antropometric measures of all subjects, existence of any ...
Fier Heide - - 2012
MOTIVATION: For the analysis of rare variants in sequence data, numerous approaches have been suggested. Fixed and flexible threshold approaches collapse the rare-variant information of a genomic region into a test statistic with reduced dimensionality. Alternatively, the rare-variant information can be combined in statistical frameworks that are based on suitable ...
Lu Xiu-Lan - - 2012
BackgroundThe diagnostic value of procalcitonin (PCT) for patients with renal impairment is unclear.MethodsWe searched multiple databases for studies published through December 2011 that evaluated the diagnostic performance of PCT among patients with renal impairment and suspected systemic bacterial infection. We summarized test performance characteristics with the use of forest plots, ...
Fulbrook Paul - - 2012
There has been no research that has investigated the psychosocial impact on children whose parents have undergone a lung transplant. The aim of this qualitative study was to describe children's concerns and understandings of their parent's transplant surgery. Artwork was used as a creative medium to enable children to portray ...
Kajita Yukie - - 2012
Biological invasions have been accelerated by a variety of human activities. Propagule pressure, the number of introduced individuals and independent introductions, is probably to be influenced by these human activities and may be an important factor for successful range expansion in new environments. We tested whether the current distribution of ...
Ambler Dana R - - 2012
Inflammation is known to be involved in the postoperative adhesion development. Interleukin (IL)-6 and tumor necrosis factor (TNF)-α are cytokines that stimulate the acute-phase reaction, which leads to a systemic reaction including inflammation, fever, and activation of the complement and clotting cascades. The goal of this study was to examine ...
Horwitz Sarah McCue - - 2012
To examine the rates and predictors of mental health services use for a nationally representative cohort of youths who had been investigated for alleged maltreatment. Data came from caregiver and caseworker baseline and 18-month interviews in the second National Survey of Child and Adolescent Well-being. These interviews took place from ...
Xu Xinsong X Department of Oncological Sciences, The Mount Sinai School of Medicine, New York, NY 10029-6574, - - 2012
Negative feedback regulation of insulin signaling involves ubiquitin-dependent degradation of insulin receptor substrate 1 (IRS1). Cullin-RING E3 ubiquitin ligase 7 (CRL7) mediates the ubiquitination of IRS1 in hyperphosphorylated form. Multisite IRS1 phosphorylation triggers interactions with CRL7 for ubiquitin modification. Insulin signaling is self-restrained when its downstream effector kinases are hyperactivated ...
Cutting Richard Simon - - 2012
To address the impact of microbial redox cycling on arsenic-bearing acid mine drainage minerals, the fate of As(V) during the microbial reduction of Fe(III) in synthetic As-bearing schwertmannites by Geobacter sulfurreducens has been investigated. During incubation, the initial rate of biological Fe(III) reduction increased with increased initial arsenic concentration. From ...
Liu Binghang - - 2012
MOTIVATION: The boost of next-generation sequencing technologies provides us with an unprecedented opportunity for elucidating genetic mysteries, yet the short read length hinders us from better assembling the genome from scratch. New protocols now exist that can generate overlapping pair-end reads. By joining the 3'-ends of each read pair, one ...
Hart Aaron - - 2012
Effect of positioning of the cyanoacrylic acid anchoring group on ring periphery of phenothiazine dye on the performance of dye sensitized solar cells (DSSCs) is reported. Two types of dyes, one having substitution on the C-3 aromatic ring (Type-1), and another through the N-terminal (Type-2) have been synthesized for this ...
Gery S - - 2012
The signal transduction pathways, orchestrating the differentiation of hematopoietic stem and progenitor cells in response to cytokine stimulation, are strictly controlled by networks of feedback loops, highly selective protein interactions and finely tuned on/off switches. In hematological malignancies, the aberrant activation of signaling pathways is usually associated with mutations in ...
Etgar Lioz - - 2012
We report for the first time on a hole conductor-free mesocopic lead iodide CH3NH3PbI3(perovskite)/TiO2 heterojunction solar cell, produced by deposition of perovskite nanoparticles from a solution of CH3NH3I and PbI2 in γ-butyrolactone on a 400nm thick film of TiO2 (anatase) nanosheets exposing (001) facets. An Au film was evaporated a ...
Rattaz Cecile - - 2012
This study focused on parents' satisfaction with the special education and care services proposed to their child with autism spectrum disorders (ASD). Data were collected in three regions of France, using a questionnaire designed for the purpose of this study. Among the 530 families contacted, 212 filled in the questionnaire ...
Pickhard A - - 2012
Chronic inflammatory diseases including tuberculosis, rheumatic disorders (rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, Wegeners's granulomatosis, relapsing polychondritis) and reflux disease are considered as systemic diseases, and may affect the larynx. The clinical symptoms are often unspecific, leading to prolonged intervals to diagnosis. Solid and haematological tumours should be considered in ...
Gerashchenko Maxim V - - 2012
Information on unique and coordinated regulation of transcription and translation in response to stress is central to the understanding of cellular homeostasis. Here we used ribosome profiling coupled with next-generation sequencing to examine the interplay between transcription and translation under conditions of hydrogen peroxide treatment in Saccharomyces cerevisiae. Hydrogen peroxide ...
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