Search Results
Results 601 - 650 of 2040
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Chuang Chao-Ming - - 2012
Context: The extraction method and the crude wound healing effects of sacchachitin from Ganoderma tsugae Murr. (Ganodermataceae) has been cited. However, its purity is still largely limited. Objective: An improvement of the fractionation protocol to purify the sacchachitin from Ganoderma lucidum L. (Ganodermataceae) (SGL) is needed. Methods: Fruiting bodies were ...
Chen Xueping - - 2012
A major hallmark of mutant SOD1-linked FALS is SOD1-immunopositive inclusions found within motor neurons. The mechanism by which SOD1 becomes aggregated, however, is unclear. In this study we aimed to investigate the role of nitrosative stress and S-nitrosylation of protein disulfide isomerase (PDI) in the formation of SOD1 aggregates. Our ...
Zhu Jun-Ling - - 2012
In-depth understanding of the activation mechanism in asymmetric organocatalysis is of great importance for rational development of highly efficient catalytic systems. In this contribution, the mechanism for the direct vinylogous Michael reaction of alpha,beta-unsaturated gamma-butyrolactam (Nu) and chalcone (EI) catalyzed by the bifunctional cinchona alkaloid thiourea organocatalyst (Cat) was studied ...
Amarilyo Gil - - 2012
BACKGROUND/PURPOSE: The American College of Rheumatology (ACR) and the Association of Rheumatology Health Professionals (ARHP) Annual Scientific Meeting is an important forum for early dissemination of novel ideas. However, unlike published studies in peer-reviewed journals, reviewers select abstracts based solely on a general summary of the research. Analyses of the ...
Dello Russo Cinzia - - 2012
The mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase with a central role in the regulation of cell growth and proliferation, and several intracellular processes, such as mRNA transcription and translation, autophagy and cytoskeletal organization. The relevance of this pathway in the regulation of the immune system is ...
Ruland Vincent - - 2012
OBJECTIVE.: This study determines the frequency and reproducibility of standardised photoprovocation in patients with cutaneous lupus erythematosus (CLE) and reports our experience over 25 years. METHODS.: Photoprovocation using a standardised protocol was evaluated retrospectively in 566 patients. The diagnosis of CLE was clinically and/or histologically confirmed in 431 patients, and ...
Dolzhnikov Dmitriy S - - 2012
A reinvestigation of the synthesis of [H(5-n)Rh(13)(CO)(24)](n-) (n = 2, 3) led to isolation of a series of Rh(19), Rh(26), and Rh(33) high-nuclearity carbonyl and carbonyl-substituted rhodium clusters. The [Rh(19)(CO)(31)](5-) (1) is electronically equivalent with [Pt(19)(CO)(22)](4-), but poor crystal diffraction data of all salts obtained to date have prevented its ...
Yazawa Koji - - 2012
The accurate (1)H positions of alanine tripeptide, A(3), with anti-parallel and parallel β-sheet structures could be determined by highly resolved (1)H DQMAS solid-state NMR spectra and (1)H chemical shift calculation with gauge-including projector augmented wave calculations.
Pickhard A - - 2012
Chronic inflammatory diseases including tuberculosis, rheumatic disorders (rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, Wegeners's granulomatosis, relapsing polychondritis) and reflux disease are considered as systemic diseases, and may affect the larynx. The clinical symptoms are often unspecific, leading to prolonged intervals to diagnosis. Solid and haematological tumours should be considered in ...
Yodthong Nuengrutai - - 2012
Abstract Objective: To investigate the factors related to changes in alveolar bone thickness during upper incisor retraction. Materials and Methods: The subjects consisted of 23 ongoing orthodontic patients (mean age 20.4 ± 2.7 years) whose upper incisors were bound for retraction. Changes in alveolar bone thickness in the retracted area were ...
Lachmann Hanna - - 2012
An important goal for interprofessional education (IPE) in clinical settings is to support healthcare students in collaboratively developing their understanding of interprofessional teamwork. The aim of this study was to investigate students' learning experiences and academic emotions as they occur in actual context in relation to collaborative and trialogical activities ...
Eirin Alfonso - - 2012
Revascularization improves blood pressure but not renal function in most patients with atherosclerotic renal artery stenosis (ARAS), possibly related to injury incurred during renal reperfusion. Bendavia, a novel tetrapeptide that inhibits mitochondrial permeability transition pore opening, reduces apoptosis, oxidative stress, and ischemia-reperfusion injury in experimental models. However, its potential for ...
Sedki Imad - - 2012
Background: The introduction of the Echelon prosthetic foot with a hydraulic self-aligning ankle adds improved adaptability to varied terrains and uneven walking surfaces. However, the specific indications for prescribing such components and the potential benefits are yet to be fully established.Case Description and Methods: Nine amputees including three bilateral amputees ...
Zheng Zuoyu - - 2012
Benign epithelial inclusions are rarely found in peripancreatic lymph nodes and have not been studied by up-to-date immunohistochemistry. Here, we describe 2 cases of benign epithelial inclusions in the peripancreatic lymph nodes with discussion of differential diagnosis. The first case was a 2.2 cm lymph node from a 61-year-old woman ...
Sakata Kouhei - - 2012
The structural changes in a bicontinuous microemulsion gel system in a sol-gel state were elucidated via determination of the apparent diffusion coefficients, which were estimated electrochemically. The temperature dependence of D(app) in the micro oil phase or the saline phase revealed complementary hysteresis, which occurred as a result of formation ...
Carlson Jenny - - 2012
Abstract The Socorro dove Zenaida graysoni, endemic to Socorro Island, was last reported in the wild in 1972. Fortunately, the species has been propagated in zoos in Europe and the USA, and plans are underway to reintroduce it to its native habitat. This will be the first known attempt to ...
Barman Samir - - 2012
We report a novel luminescent Al-based metal-organic gel comprising 1,4,5,8-triptycenetetracarboxylic acid, which exhibits highly sensitive detection towards nitro aromatic compounds particularly picric acid. Furthermore, under identical reaction conditions, using a Co(ii) salt instead, a novel 3D framework material, trip-MOF-1, was isolated and its sensitivity towards picric acid was also evaluated.
Subramanian Sankaran - - 2012
Narrow-line spin probes derived from the trityl radical have led to the development of fast in vivo time-domain EPR imaging. Pure phase-encoding imaging modalities based on the single-point imaging scheme have demonstrated the feasibility of three-dimensional oximetric images with functional information in minutes. In this article, we explore techniques to ...
Sibon David - - 2012
PURPOSESystemic anaplastic large-cell lymphoma (ALCL) is a T-cell lymphoma, whose anaplastic lymphoma kinase (ALK) expression varies according to age. Long-term outcomes of chemotherapy-treated adults are not definitively established and should be evaluated. PATIENTS AND METHODSPatients treated in three Groupe d'Étude des Lymphomes de l'Adulte prospective clinical trials with confirmed systemic ...
Imajoh Masayuki - - 2012
In Japan, Mycobacterium sp. was isolated from the yellowtail, Seriola quinqueradiata, as a Mycobacterium marinum-like mycobacterium. The species was identified as M. marinum by a commercial mycobacterial DNA-DNA hybridization kit. Nevertheless, PCR restriction analysis of DNA of the RNA polymerase β-subunit gene definitively showed that Mycobacterium sp. is M. ulcerans. ...
Hsu Y-L - - 2012
The skeleton is the most common metastatic site for breast cancer, with bone metastasis causing pain as well as risk of pathological fractures. Interaction between tumors and the bone microenvironment creates a vicious cycle that accelerates both bone destruction and cancer progression. This study is the first to analyze the ...
Okuma Kentaro - - 2012
An efficient route to 4-aryl-2-naphthols from arynes and aroylacetones was developed by carbon-carbon bond insertion followed by an intramolecular aldol reaction and dehydration. Benzyne derived from 2-(trimethylsilyl)phenyl triflate reacted with benzoylacetones in refluxing acetonitrile to give 4-aryl-2-naphthols and 3-aryl-1-naphthols.
Bao Wenzhong - - 2012
Graphene is nature's thinnest elastic membrane, and its morphology has important impacts on its electrical, mechanical and electromechanical properties. Here we report manipulation of the morphology of suspended graphene via electrostatic and thermal control. By measuring the out-of-plane deflection as function of applied gate voltage and number of layers, we ...
Do Diana V - - 2012
OBJECTIVE To assess the benefit of increased follow-up and treatment with ranibizumab between months 24 and 36 in the Ranibizumab for Edema of the Macula in Diabetes (READ-2) Study. DESIGN Prospective, interventional, multicenter follow-up of a randomized clinical trial. METHODS Patients who agreed to participate between months 24 and 36 ...
Mun Sue Jean - - 2012
BACKGROUND: The conventional escalation regimen for sublingual immunotherapy (SLIT) in patients with allergic rhinitis has been proven to be safe and successful in reducing allergic symptoms. However, few studies compared the efficacy and safety between a conventional escalation regimen for SLIT and once-daily SLIT. The aim of the present study ...
Kuwata Mikinori - - 2012
The interconversion of atmospheric organic particles among solid, semisolid, and liquid phases is of keen current scientific interest, especially for particles of secondary organic material (SOM). Herein, the influence of phase on ammonia uptake and subsequent particle-phase reactions was investigated for aerosol particles of adipic acid and α-pinene ozonolysis SOM. ...
Manvelian Garen - - 2012
Background.  Safety concerns associated with nonsteroidal anti-inflammatory drugs (NSAIDs) have prompted the development of new formulations that minimize adverse events (AEs) and maintain efficacy. Objectives.  To determine the analgesic efficacy and safety of an investigational, proprietary, nano-formulated, oral diclofenac (nano-formulated diclofenac) compared with placebo in subjects with acute dental pain. ...
Naredo Esperanza - - 2012
OBJECTIVE.: To investigate the sensitivity for detecting subclinical synovitis of different reduced joint ultrasound (US) assessment models as compared with a comprehensive US assessment in RA patients in clinical remission. METHODS.: Sixty-seven RA patients (50 women, 17 men) in clinical remission judged by their consultant rheumatologist, treated with methotrexate were ...
Zhu Yuan - - 2012
A clear clinical management pathway (conventional in vitro fertilization, IVF or intracytoplasmic sperm injection, ICSI) for treating patients with teratozoospermia is lacking. Here we conducted a retrospective study of fertility indices in 2,178 IVF/ICSI cycles in order to reevaluate clinical management of couples with isolated teratozoospermia (< 4% morphologically normal ...
Lombardo Giuseppe M - - 2012
The vast literature concerning caffeic acid and its derivatives lacks any reference to the solid state structures of its inorganic salts as these crystals are quite difficult grow. Most of the already published works deal with computational studies of these compounds as well as investigations of their behaviour in solution. ...
Liu Yuan-Ting - - 2012
A Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase mutant, ERG7(T384Y/Q450H/V454I), produced parkeol but not lanosterol as the sole end product. Parkeol undergoes downstream metabolism to generate compounds 9 and 10. In vitro incubation of parkeol produced a product profile similar to that of the in vivo experiment. In summary, parkeol undergoes a metabolic ...
Stahler Daniel R - - 2012
Reproduction in social organisms is shaped by numerous morphological, behavioural and life-history traits such as body size, cooperative breeding and age of reproduction, respectively. Little is known, however, about the relative influence of these different types of traits on reproduction, particularly in the context of environmental conditions that determine their ...
Tayebi Noureddine - - 2012
The emergence of new technologies, such as whole genome sequencing systems, which generate a large amount of data, is requiring ultrahigh storage capacities. Due to their compactness and low power consumption, probe-based memory devices using Pb(Zr0.2Ti0.8)O3 (PZT) ferroelectric films are the ideal candidate for such applications where portability is desired. ...
Peyre M - - 2012
Aggressive variants of meningiomas (WHO grade II and III) represent up to 30% of those tumors that are among the most common primary central nervous system tumors in adults. Currently, there is no effective treatment for grade-II and -III meningiomas, the main treatment remaining surgical excision. Genetic studies have highlighted ...
Bas Esperanza - - 2012
This review covers the molecular mechanisms involved in hair cell and hearing losses which can result from trauma generated during the process of cochlear implantation and the contributions of both the intrinsic and extrinsic cell death signaling pathways in producing these trauma/inflammation induced losses. Application of soft surgical techniques to ...
Warren Zack - - 2012
There is limited evidence surrounding the ability of families of children with autism spectrum disorders to access and implement recommended interventions following diagnosis. The distress a family may encounter with regard to inability to access recommended services is also poorly understood. In this study, we present preliminary data regarding implementation ...
Ralls Matthew W - - 2012
BACKGROUND:Ethanol lock therapy (ELT) has been shown to reduce the incidence of catheter-related blood stream infections (CRBSI) in intestinal failure (IF) patients. Dosing and frequency remains undefined. Scrutiny of pharmaceutical facilities by the Food and Drug Administration led to the voluntary shutdown of the sole supplier of ethanol, resulting in ...
Jiao Qingze - - 2012
The hollow Co(3)O(4) microspheres were prepared by a gas-liquid diffusion reaction in the presence of ionic liquid [Bmim][BF(4)] in combination with calcination at 300 °C. Their structures and morphologies were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Raman spectrometry, and X-ray photoelectron spectroscopy. The growth mechanism of ...
Da Rocha Gomes Sonia - - 2012
The human matrix metalloprotease 9 (hMMP-9) is involved in many physiological processes such as tissue remodeling. Its overexpression in tumors promotes the release of cancer cells thus contributing to tumor metastasis. It is a relevant marker of malignant tumors. We selected an RNA aptamer containing 2'fluoro, pyrimidine ribonucleosides, that exhibits ...
Ma G - - 2012
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). HTLV-1 bZIP factor (HBZ), the viral gene transcribed from the antisense strand, is consistently expressed in ATL cells and promotes their proliferation. In this study, we found that a Wnt pathway-related protein, disheveled-associating protein ...
Gassner Davina - - 2012
This article presents a unique approach for the delivery of gene therapy vectors into the cochlea of the laboratory rat. Mice and guinea pigs are established in vivo models for cochlear gene therapy each of which has distinct advantages and disadvantages. The rat has some of the molecular advantages of ...
Feucht W - - 2012
Normally, needles of Taxus baccata during the growth period prominently stain blue for nuclear flavanols with the histochemical DMACA procedure. However, under excess heat and drought conditions, nuclear flavanols of current-year needles decline to zero. Nevertheless, greenish-yellow-coloured flavonols (quercetin derivatives) were still observed in nuclei. All of these yellow nuclei ...
Fok Henry - - 2012
Arterial tone in muscular conduit arteries may influence pressure wave reflection through changes in diameter and pulse wave velocity. We examined the relative specificity of vasodilator drugs for radial artery and forearm resistance vessels during intrabrachial arterial infusion. The nitric oxide (NO) donors, nitroglycerine and nitroprusside, and brain natriuretic peptide ...
Estabrooks Paul A - - 2012
The Reach Effectiveness Adoption Implementation Maintenance (RE-AIM) model was developed to improve the likelihood of translating health promotion intervention research into practice. In their evaluation of grant proposals focusing on the dissemination and implementation, Kessler and colleagues (2012) proposed a method for evaluating the degree to which RE-AIM was "fully ...
Martin C E - - 2012
Leaf temperatures were lower when light entry at the leaf tip window was prevented through covering the window with reflective tape, relative to leaf temperatures of plants with leaf tip windows covered with transparent tape. This was true when leaf temperatures were measured with an infrared thermometer, but not with ...
Duque Gustavo - - 2012
Infiltration of bone marrow with fat is a prevalent feature in people with age-related bone loss and osteoporosis, which correlates inversely with bone formation and positively with high expression levels of peroxisomal proliferator-activated receptor gamma (PPARγ). Inhibition of PPARγ thus represents a potential therapeutic approach for age-related bone loss. In ...
Doritchamou Justin - - 2012
Background. Plasmodium falciparum-infected erythrocytes (IE) adhere to host cell receptors allowing parasites to sequester in deep vascular beds of various organs. This defining phenomenon of malaria pathogenesis is key to the severe clinical complications associated with cerebral and placental malaria. The principal ligand associated with the binding to chondroitin sulfate A ...
Zuazo Alicia - - 2012
In the search for new molecules with potential antiangiogenic activity, we found that several imidoselenocarbamate derivatives effectively suppressed the expression of vascular endothelial growth factor (VEGF) induced by hypoxia in NCI-H157 tumor cells. Mechanistic studies indicated that these compounds inhibited STAT3 phosphorylation triggered by hypoxia, suggesting that inhibition of STAT3 ...
Smith Angela H - - 2012
OBJECTIVE(S): Treatment credibility and client satisfaction have received relatively little research attention, but extant findings indicate that some clients and therapists differ in their perceptions of what is helpful about therapy, with greater divergence related to poorer outcomes. This study examined relationships between treatment credibility, perceptions of therapy helpfulness, and ...
Matsushita Nobuhisa - - 2012
The incidence of cerebral aneurysms is higher in women than in men, especially postmenopause. Although hypertension is thought to be associated with a high incidence of stroke, not all patients with unruptured cerebral aneurysms are hypertensive. The possibility of water-free Na(+) storage associated with hypertension has been raised. However, whether ...
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