Search Results
Results 551 - 600 of 2040
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Koohbanani Bianca - - 2012
This institutional retrospective review studied Ewing sarcomas from 1987-2011. Among 135 patients, 127 (19 Hispanic and 108 white/non-Hispanic) were analyzed (excluding small sample sized groups) finding 15% Hispanic, 85% non-Hispanic, 27% <18 years, 21% >40 years and 1-272 months follow-up (median 41). Age was significantly associated with overall survival (OS) (p = ...
Sowerby Leigh J - - 2012
BACKGROUND: Endoscopic anterior skull-base surgery has been previously suggested to cause a significant deterioration in olfactory function. Given the impact on quality of life, the objective of this study was to determine the effect of a unilateral middle-turbinate-sacrificing approach on olfactory function and sinonasal outcome. METHODS: Prospective cohort study comparing ...
Rudmik Luke - - 2012
BACKGROUND: Topical therapies have become an integral component in the management plan for chronic rhinosinusitis (CRS). Several topical therapy strategies have been evaluated, but a formal comprehensive evaluation of the evidence has never been performed. The purpose of this article is to provide an evidence-based approach for the utilization of ...
Montalbán Itziar Aurora - - 2012
In Pinus radiata D. Don, the transition from the juvenile to the mature phase is characterized by a reduction in the tree's organogenic potential, which is usually reverted in breeding programs by reinvigoration procedures to enable vegetative propagation. In this work we have determined the best culture conditions for in ...
Chan Hsun-Liang - - 2012
PURPOSE: The degree of difficulty in performing lateral window sinus augmentation may depend on the morphology of the maxillary sinus. The aim of this was to measure the distances between the medial and lateral sinus wall (sinus width [SW]) at different levels and apply those SW values to formulate a ...
Ding Xilai - - 2012
Allogeneic hematopoietic cell transplantation is an established treatment for hematologic and nonhematologic malignancies. Donor-derived immune cells can identify and attack host tumor cells, producing a graft-versus-tumor (GVT) effect that is crucial to the effectiveness of the transplantation therapy. CBLB502 is a novel agonist for TLR5 derived from Salmonella flagellin. On ...
Schäfer Anja - - 2012
In continuation of our previous work, several 2,3,5-triarylpyrroles with chlorine or fluorine substituents in the aryl residues were synthesised and tested for estrogen receptor (ER) binding at isolated ERα/ERß receptors (HAP assay) and in transactivation assays using ERα-positive MCF-7/2a as well as U2-OS/ERα and U2-OS/ERß cells. In the competition experiment ...
Bilge Yildiz Dallar - - 2012
Objective: This study aims to explore the relation between childhood obesity and procoagulant and anticoagulant systems. Method: Fifty-one obese children and 32 normal-weighted children with similar age and gender distribution and between ages of 5 and 16 years were recruited to the study. Antropometric measures of all subjects, existence of any ...
Fier Heide - - 2012
MOTIVATION: For the analysis of rare variants in sequence data, numerous approaches have been suggested. Fixed and flexible threshold approaches collapse the rare-variant information of a genomic region into a test statistic with reduced dimensionality. Alternatively, the rare-variant information can be combined in statistical frameworks that are based on suitable ...
Lu Xiu-Lan - - 2012
BackgroundThe diagnostic value of procalcitonin (PCT) for patients with renal impairment is unclear.MethodsWe searched multiple databases for studies published through December 2011 that evaluated the diagnostic performance of PCT among patients with renal impairment and suspected systemic bacterial infection. We summarized test performance characteristics with the use of forest plots, ...
Fulbrook Paul - - 2012
There has been no research that has investigated the psychosocial impact on children whose parents have undergone a lung transplant. The aim of this qualitative study was to describe children's concerns and understandings of their parent's transplant surgery. Artwork was used as a creative medium to enable children to portray ...
Kajita Yukie - - 2012
Biological invasions have been accelerated by a variety of human activities. Propagule pressure, the number of introduced individuals and independent introductions, is probably to be influenced by these human activities and may be an important factor for successful range expansion in new environments. We tested whether the current distribution of ...
Bahadur Ranjit - - 2012
Black carbon (BC) is functionally defined as the absorbing component of atmospheric total carbonaceous aerosols (TC) and is typically dominated by soot-like elemental carbon (EC). However, organic carbon (OC) has also been shown to absorb strongly at visible to UV wavelengths and the absorbing organics are referred to as brown ...
King Evan R - - 2012
Using the dipyrrin ligand (ArLH = 5-mesityl-1,9-(2,4,6-triphenylphenyl)dipyrrin), four-coordinate CoII (ArL)CoCl(py) and a three-coordinate CoI complexes (ArL)Co(py) were synthesized and characterized. Reaction of (ArL)Co(py) with tBuN3 afforded an isolable three-coordinate, Co-imido complex (ArL)Co(NtBu) that is paramagnetic at room temperature. Variable-temperature 1H NMR and SQUID magnetometry revealed (ArL)Co(NtBu) undergoes a thermally induced ...
van Hooff Sander R - - 2012
PURPOSECurrent assessment of lymph node metastasis in patients with head and neck squamous cell carcinoma is not accurate enough to prevent overtreatment. The aim of this study was validation of a gene expression signature for distinguishing metastasizing (N+) from nonmetastasizing (N0) squamous cell carcinoma of the oral cavity (OSCC) and ...
Gusenbauer S - - 2012
The epidermal growth factor receptor (EGFR) is overexpressed and activated in many human cancers and predicts poor patient prognosis. Targeting the kinase domain with specific EGFR tyrosine kinase inhibitors (TKIs) like gefitinib and erlotinib has been used in anticancer treatments. However, patient response rates in different human cancers were initially ...
Mok Cc - - 2012
OBJECTIVES: To study the level of anti-mullerian hormone (AMH) and its relationship with age and previous cyclophosphamide (CYC) exposure in patients with systemic lupus erythematosus (SLE). METHOD: Consecutive female patients aged 18-52 years who had menstruation in the preceding 12 months and fulfilled ?4 ACR criteria for SLE were recruited. ...
Sharifudin Syazana Akmal - - 2012
Context: Moringa oleifera Lam. (Moringaceae) is a rich source of essential minerals and antioxidants; it has been used in human and animal nutrition. The leaves and flowers are being used by the population with great dietary importance. Objective: The present study was to investigate the therapeutic effects of the hydroethanolic ...
Yamada T - - 2012
Despite initial dramatic response, epidermal growth factor receptor (EGFR) mutant lung cancer patients always acquire resistance to EGFR-tyrosine kinase inhibitors (TKIs). Gatekeeper T790M mutation in EGFR is the most prevalent genetic alteration underlying acquired resistance to EGFR-TKI, and EGFR mutant lung cancer cells are reported to be addictive to EGFR/Akt ...
Vincent C - - 2012
This review covers the design, structure, and function of auditory brainstem implants. Auditory brainstem implants (ABIs) are auditory prostheses initially designed to treat deafness in patients with neurofibromatosis type 2 (NF2). NF2 typically results in deafness due to disruption of the cochlear nerves. When the tumors are removed the auditory ...
Salam M A - - 2012
We report that two mitogen-activated protein kinases (MAPKs), MPK9 and MPK12, positively regulate abscisic acid (ABA)-induced stomatal closure in Arabidopsis thaliana. Yeast elicitor (YEL) induced stomatal closure accompanied by intracellular reactive oxygen species (ROS) accumulation and cytosolic free calcium concentration ([Ca(2+) ](cyt) ) oscillation. In this study, we examined whether ...
van Steensel Francisca Ja - - 2012
The psychometric properties of a questionnaire developed to assess symptoms of anxiety disorders (SCARED-71) were compared between two groups of children: children with high-functioning autism spectrum disorder and comorbid anxiety disorders (ASD-group; n = 115), and children with anxiety disorders (AD-group; n = 122). Anxiety disorders were established with a ...
Jung Da-Woon - - 2012
Muscle diseases are major health concerns. For example, ischemic heart disease is the third most common cause of death. Cell therapy is an attractive approach for treating muscle diseases, although this is hampered by the need to generate large numbers of functional muscle cells. Small molecules have become established as ...
Hügle Thomas - - 2012
OBJECTIVE.: The role of tumor necrosis factor (TNF) in Systemic Sclerosis (SSc) remains controversial. We aimed to investigate the influence of TNF receptor (TNFR) co-stimulated lymphocytes on collagen expression in fibroblasts. METHODS.: TNFR expression on mononuclear cells from dermis and blood of SSc patients was assessed by flow cytometry. Peripheral ...
Adel-Patient K - - 2012
The immunomodulatory potential of fragments derived from the cow's milk allergen bovine ß-lactoglobulin (BLG) was assessed in a mouse model of oral tolerance (OT). Native BLG (nBLG) and chemically denatured BLG (lacking S-S bridges, dBLG), products resulting from their hydrolysis using cyanogen bromide (CNBr) and some synthetic peptides were produced ...
Chimge N-O - - 2012
The three RUNX family members are lineage specific master regulators, which also have important, context-dependent roles in carcinogenesis as either tumor suppressors or oncogenes. Here we review evidence for such roles in breast cancer (BCa). RUNX1, the predominant RUNX family member in breast epithelial cells, has a tumor suppressor role ...
Duan Deyong - - 2012
The sinus node of yak has been studied by the histological methods and transmission electron microscopy. The sinus node artery of yak was also determined by the injection-corrosion casting technique, the angiography, and histological methods. The results showed that the sinus node of yak contained an extensive framework of collagen ...
Duncan Jeremy S - - 2012
Here, we review the molecular basis of mechanosensory cell and mechanosensory organ development and evolution with an emphasis on the conservation of transcription factors and emerging data on conserved gene networks. The ear, the organ of vertebrates dedicated to the perception of sound and balance, perceives these stimuli with the ...
Qin Wen-Bing - - 2012
A simple, convenient and efficient metal-free catalyzed oxidative trimeric reaction of indoles toward a variety of 2-(1H-indol-3-yl)-2,3'-biindolin-3-one derivatives in moderate to excellent yields has been developed. This transformation proceeds via a tandem oxidative homocoupling reaction by using TEMPO in air as an environmentally benign oxidant. This methodology provides an alternative ...
Huang Xiao-Fei - - 2012
Optically active spirocyclohexaneoxindole motifs are very important building blocks for preparations of biologically active complexes, natural products, and pharmaceutical compounds. Herein, we report the syntheses of enantiopure spirocyclohexaneoxindoles through domino Michael-Aldol reactions between isatin derived alkenes and pentane-1,5-dial in the presence of diphenylprolinol silyl ether as an aminocatalyst. As a ...
Felizeter Sebastian - - 2012
An uptake study was carried out to assess the potential human exposure to perfluorinated alkyl acids (PFAAs) through the ingestion of vegetables. Lettuce (Lactuca sativa) was grown in PFAA-spiked nutrient solutions at four different concentrations, ranging from 10 ng/l to 10 µg/l. Eleven perfluorinated carboxylic acids (PFCAs) and three perfluorinated ...
Jones Kelly L - - 2012
Down syndrome (DS) is recognized by characteristic facial features, intellectual disability, and an increased risk for cardiac malformations and duodenal atresia. Recently, Hirschsprung disease (HSCR), or congenital aganglionic megacolon, has been seen more often among patients with DS. Given the systemic nature of DS-related features, it is natural to attribute ...
Barbarulo A - - 2012
Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM). Jun N-terminal kinase (JNK) signaling has been implicated in MM pathogenesis, but its function is unclear. To elucidate the role of JNK in MM, we evaluated the specific functions of the two major JNK proteins, ...
González González Nieves L - - 2012
Objective: To determine the effect of using customized vs. standard population birthweight curves to define large for gestational age (LGA) infants. Methods: We analyzed data obtained from 2,097 singleton pregnancies using three different methods of classifying newborn birthweight: standard population curves, British or Spanish customized curves. We recorded maternal characteristics, ...
Comarmond Chloe - - 2012
OBJECTIVE: Earlier studies on eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome; EGPA), with limited patient numbers and follow-up durations, demonstrated that ANCA+ and ANCA- patients differed clinically at diagnosis but not in their outcomes. Our aims were to describe the main characteristics of a larger patient cohort and their long-term outcomes. ...
Park Sungjin - - 2012
Here we report the discovery that bifunctional thiol- and amine-reactive electrophiles serve as mechanism-based covalent cross-linkers for HECT E3 ubiquitin ligase/substrate pairs. We demonstrate that these chemical cross-linkers covalently cross-link the catalytic Cys residue of the yeast HECT E3 ubiquitin ligase Rsp5 with the Lys of the ubiquitination site in ...
Celle Sébastien - - 2012
Previous literature has shown mixed results regarding the association between blood pressure levels and brain volume reduction. The objectives of this study were to determine whether high blood pressure levels were associated with focal brain volume reduction and whether high blood pressure-related focal brain volume reduction was associated with a ...
Friestad Christine - - 2012
BACKGROUND: Women prisoners are known to suffer from an accumulation of factors known to increase the risk for several major health problems. This study examines the prevalence of adverse childhood experiences (ACE) and the relationship between such experiences and suicide attempts and drug use among incarcerated women in Norway. METHODS: ...
Dugaret Elodie - - 2012
Older patients represent an increasing population in emergency department (ED) with underlying diseases and longer ED length of stay, which are potential risk factors of pressure ulcers (PUs). The aim of the study was to determine the prevalence and incidence rates of PUs in an Emergency Department and to analyse ...
de Souza E O - - 2012
This study investigated the chronic effects of concurrent training (CT) on morphological and molecular adaptations. 37 men (age=23.7±5.5 year) were divided into 4 groups: interval (IT), strength (ST) and concurrent (CT) training and a control group (C) and underwent 8 weeks of training. Maximum strength (1RM) and muscle cross-sectional area ...
Yu Han-Jie - - 2012
Protein glycosylation plays an important role in the pathogenesis and progression of various liver diseases. However, little is known about the precise alterations in protein glycosylation or the potential correlation between glycan-related genes expression and glycan profiles in liver fibrosis. The aim of the study was to investigate potential associations ...
Yu Haibo - - 2012
A lysosome-specific and two-photon fluorescent probe Lyso-NINO demonstrates high selectivity and sensitivity toward NO, lower cytotoxicity and perfect lysosomal localization. With the aid of Lyso-NINO, the first NO's capture within lysosomes of macrophage cells has been achieved in both two-photon fluorescent microscopy and flow cytometry.
Siddhanta Soumik - - 2012
We demonstrate here a novel high surface area GaN nanowall network substrate with plasmonic Ag nanodroplets, that can be employed as a highly sensitive, reproducible and charge independent SERS substrate. The uniformity of the size and distribution of the Ag droplets and the absence of linker ligands, result in large ...
Yousefi Reza - - 2012
The needs for diverse inhibitors of α-glucosidase (α-Gls) encouraged us to synthesize five different poly-hydroxy functionalized pyrimidine-fused heterocyclic (PHPFH) molecules, having either aliphatic or aromatic side chains (C(1)-C(5)) and their inhibitory activities were examined spectroscopically against yeast and mouse intestinal α-Gls. The results revealed that aromatic substitution of the synthetic ...
Hwang Shin - - 2012
In liver transplantation, a left lateral section (LLS) graft may have unusual variant left hepatic vein (LHV) anatomy. This study was designed to analyze the incidence of unusual variant LHV and to determine technical methods for its effective reconstruction in infant recipients weighing around 10 Kg or less. The study ...
Broom Alex F - - 2012
Cancer is emerging as a key disease in India, but there has been virtually no research exploring understandings of cancer and practices of communication within oncology settings. This is despite the fact that the Indian context presents clinicians, patients, and family members with a range of unique challenges, including those ...
Banczerowski Péter - - 2012
Background The conventional posterior approaches, which may involve multilevel laminectomies and facetectomies, may lead to spinal deformities, instability, or subluxation. Our objective was to develop a minimally invasive approach suitable for exploring neuromas with an intraforaminal component in the cervical spine, with the aim of preserving mechanically relevant bone structures and ...
Li Na - - 2012
There is growing interest in thin, lightweight, and flexible energy storage devices to meet the special needs for next-generation, high-performance, flexible electronics. Here we report a thin, lightweight, and flexible lithium ion battery made from graphene foam, a three-dimensional, flexible, and conductive interconnected network, as a current collector, loaded with ...
Liang Jing - - 2012
Estrogen exhibits a broad spectrum of physiological functions ranging from regulation of the menstrual cycle and reproduction to modulation of bone density, brain function, and cholesterol mobilization. Despite the beneficial actions of endogenous estrogen, sustained exposure to exogenous estrogen is a well-established risk factor for various cancers. We summarize our ...
Esposito Katherine - - 2012
Introduction: Type 2 diabetes is a chronic and progressive disease, and ultimately, most patients will require insulin therapy for the optimization of their glycemic control. Areas covered: We review the recent literature investigating the efficacy and safety of the insulin analogue lispro in type 2 diabetes. Relevant publications were identified ...
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