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Results 501 - 550 of 2041
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Couderc M - - 2012
OBJECTIVE: To study the influence of several factors (rheumatoid factor [RF], anti-cyclic citrullinated peptid [anti-CCP], serum immunoglobulin [Ig] level, Epstein Barr virus [EBV] load) on clinical response to RTX after 6 months in rheumatoid arthritis (RA) patients. METHOD: Sixty-four patients receiving RTX (two 1g doses, 2weeks apart) for active RA ...
Rajanikanth V - - 2012
The folding-unfolding of structurally similar proteins belonging to a family have long been a focus of investigation for stating structure-(un)folding relationship. Such studies are yet to bring a consensus upon whether structurally similar domains follow common or different unfolding pathways. Members of βγ-crystallin superfamily which consists of structurally similar proteins ...
Watermeyer Jennifer - - 2012
Objective: Providing appropriate feedback to caregivers is an important part of the paediatric audiological assessment. This preliminary study explored caregiver recall and understanding of audiological diagnostic information subsequent to an initial paediatric diagnostic assessment. Design: A qualitative study was conducted at an audiology clinic at a hospital in South Africa. ...
Watanabe Noriyoshi - - 2012
The renin-angiotensin system is believed to influence blood pressure (BP) during pregnancy, but the associations between BP during pregnancy and the soluble form of the (pro)renin receptor (s[P]RR), a new component of the tissue renin-angiotensin system, remain undetermined. In this prospective cohort study of 437 pregnant women with normal BP ...
Jimbo R - - 2012
Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve ...
Nitzan Erez - - 2012
The dorsal domains of the neural tube and somites are transient embryonic epithelia; they constitute the source of neural crest progenitors that generate the peripheral nervous system, pigment cells and ectomesenchyme, and of the dermomyotome that develops into myocytes, dermis and vascular cells, respectively. Based on the variety of derivatives ...
Bergeron Karl-F - - 2012
Hirschsprung's disease, also known as aganglionic megacolon, derives from a congenital malformation of the enteric nervous system (ENS). It displays an incidence of 1 in 5000 live births with a 4:1 male to female sex ratio. Clinical signs include severe constipation and distended bowel due to a non-motile colon. If ...
Brown Simon - - 2012
Abstract The infective larvae of Teladorsagia circumcinta have a protective sheath which is lost soon after they reach the rumen of the sheep. Incubation in vitro with 50 mM imidazole caused more than 75% of L3 T. circumcincta to start exsheathing within 2 h. The initiation of exsheathing was less ...
Baur Xaver - - 2012
BACKGROUND: Airborne enzymes behave as potent respiratory allergens. Till date, allergic disorders caused by genetically engineered enzymes widely used in the industry, have not been reported. RESULTS AND CONCLUSIONS: We describe a worker employed in the detergent industry who developed asthma and rhinitis from IgE-mediated sensitization to the thermostable endo-alpha-amylase ...
Sambroni Elisabeth - - 2012
The general rules established from mammalian species for the regulation of spermatogenesis by gonadotropins may not be fully relevant in fish. Particularly, Fsh is as potent as Lh to stimulate steroidogenesis and the Fsh receptor is expressed in the Leydig cells. In seasonal breeders, Fsh is likely the major gonadotropin ...
Su Nan - - 2012
H1 calponin (CNN1) is known as a smooth muscle-specific, actin-binding protein which regulates smooth muscle contractive activity. Although previous studies have shown that CNN1 has effect on bone, the mechanism is not well defined. To investigate the role of CNN1 in maintaining bone homeostasis, we generated transgenic mice overexpressing Cnn1 ...
Shi Haibin - - 2012
Real-time monitoring of cell apoptosis could provide valuable insights into early detection of therapy efficiency and evaluation of disease progression. In this work, we designed and synthesized a new live-cell permeable, fluorescent light-up probe for real-time cell apoptosis imaging. The probe is comprised of a hydrophilic caspase-specific Asp-Glu-Val-Asp (DEVD) peptide ...
Blasco Salvador - - 2012
The crystal structure of a binuclear Mn(III) complex of a scorpiand-like ligand (L) displays an unsupported single oxo bridging ligand with a Mn(III)-O-Mn(III) angle of 174.7°. Magnetic susceptibility measurements indicate strong antiferromagnetic coupling between the two metal centers. DFT calculations have been carried out to understand the magnetic behavior and ...
Bakker E R M - - 2012
Apc-driven tumor formation in patients and Apc-mutant mouse models is generally attributed to increased levels of β-catenin signaling. We and others have proposed that a specific level of β-catenin signaling is required to successfully initiate tumor formation, and that each tissue prefers different dosages of signaling. This is illustrated by ...
Keric Naureen - - 2012
Background We report the rare case of an adult transsphenoidal meningoencephalocele and outline the microneurosurgical strategy. Clinical history, the findings of computerized tomography (CT) scans and magnetic resonance imaging (MRI), the microsurgical procedure, and histopathology are reported.Case Report A 54-year-old female patient complained about cerebrospinal fluid (CSF) rhinorrhea; a transnasal biopsy of ...
Berr Maximilian J - - 2012
We introduce size-selected subnanometer cluster catalysts deposited on thin films of colloidal semiconductor nanocrystals as a novel platform to obtain atomic scale insight into photocatalytic generation of solar fuels. Using Pt-cluster-decorated CdS nanorod films for photocatalytic hydrogen generation as an example, we determine the minimum amount of catalyst necessary to ...
Giménez-Benavides L - - 2012
Seeds of high-mountain species are thought to germinate rapidly, synchronously and at high percentages after a cold period, with limited dependence on the external environment; yet, empirical evidence only partially supports this behaviour. We performed a comparative study of the germination response of two closely related taxa along an altitude ...
Witt Benjamin L - - 2012
Background: Fine needle aspiration (FNA) with ultrasound guidance is one of the optimal techniques for the diagnostic evaluation of thyroid nodules. A significant subset of thyroid FNAs continue to be inadequate for interpretation, which potentially leads to increased costs from repeat aspirations. Numerous studies have been published regarding the influence ...
Papaz Tanya - - 2012
BACKGROUND:Consenting minors for genetics research and biobanking involves ethical and social challenges. We examined factors influencing participation rates in a population-based biorepository for childhood heart disease.METHODS:Individuals were prospectively enrolled across 7 centers in Ontario by using a standardized consent form. Individuals were approached for consent for the donation of blood/saliva ...
Li Yin-Ji - - 2012
Nordihydroguaiaretic acid (NDGA) is known to have prominent anticancer activity against several cancers, and is also known to be an inhibitor of 5-lipoxygenase (5-LO). In this study, we investigated the regulatory function of NDGA on inflammatory bone destruction mediated by osteoclasts. NDGA markedly inhibited receptor activator of nuclear factor-κB (NF-κB) ...
Oliveira Sophia L B - - 2012
The identification and isolation of multipotent neural stem and progenitor cells in the brain, giving rise to neurons, astrocytes, and oligodendrocytes initiated many studies in order to understand basic mechanisms of endogenous neurogenesis and repair mechanisms of the nervous system and to develop novel therapeutic strategies for cellular regeneration therapies ...
Liu Tian-Fu - - 2012
ABSTRACT: Using a ligand bearing a bulky hydrophobic group, a "Shish Kabob"of nanocages has been assembled through either a one-fell-swoop or a step-by-step procedure by varying the dielectric constant of the assembly mixture. A hydrophobic solvent breaks down the chain to discrete nanocages while a hydrophilic solvent reverses the procedure. ...
Joo Nam-Seok - - 2012
The relative contributions of calcium and vitamin D to calcium metabolism and bone mineral density (BMD) have been examined previously, but not in a population with very low calcium intake. To determine the relative importance of dietary calcium intake and serum 25-hydroxyvitamin D [25(OH)D] concentration to calcium metabolism and bone ...
Mun Se Hwan - - 2012
CD74 is a type II transmembrane protein that can act as a receptor for macrophage migration inhibitory factor (MIF) and plays a role in MIF-regulated responses. We reported that MIF inhibited osteoclast formation and MIF KO mice had decreased bone mass. We therefore examined if CD74 was involved in the ...
van Jaarsveld M T M - - 2012
Epithelial ovarian cancer is the most lethal gynecological malignancy in the Western world. A major impediment for the successful treatment is the development of drug resistance. The molecular processes that contribute to resistance have been extensively studied; however, there is not much known about regulation by microRNAs (miRNAs). We compared ...
Yadav Yad Ram - - 2012
Background The endoscopic excision of the odontoid process in irreducible atlantoaxial dislocation (AAD) can be achieved by transnasal, transoral, and transcervical approaches. Endoscopic transoral technique has been found to be effective and safe. It avoids palatal splitting or prolonged retraction. We are reporting our experience of 34 cases. The relevant literature ...
Kasabwala Khushabu - - 2012
BACKGROUND: The extensive amount of medical literature available on the Internet is frequently accessed by patients. To effectively contribute to healthcare decision-making, these online resources should be worded at a level that is readable by any patient seeking information. The American Medical Association and National Institutes of Health recommend the ...
Zhang Shen - - 2012
Radical polymerization from a single initiator molecule in a microenvironment is a nearly ideal system in which bimolecular termination, solution concentration, and viscosity changes could be neglected. In this study, we provide two facile methods of preparing polymers via atom-transfer radical polymerization (ATRP) under single-initiator conditions: tether initiators on planar ...
Carhart-Harris Robin L - - 2012
Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network and thalamocortical functional connectivity (FC) using functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions of psilocybin and placebo in 2 task-free resting-state scans. Primary analyses ...
Hardy Sam A - - 2012
OBJECTIVES: This study examined the roles of identity formation and moral identity in predicting college student mental health (anxiety and depressive symptoms), health-risk behaviors (hazardous alcohol use and sexual risk taking), and psychological well-being (self-esteem and meaning). METHOD: The sample comprised 9,500 college students (aged 18-25 years, mean = 19.78, standard ...
Touwslager Robbert N H - - 2012
Low birth weight and accelerated infant growth are associated with cardiovascular disease in adulthood. Endothelial dysfunction is regarded as a precursor of atherosclerosis and is also related to infant growth. We aimed to examine whether an association between infant growth and endothelial function is already present during discrete periods of ...
Lucchese Alessandra - - 2012
SummaryThe aim of the study was to determine the prevalence of white-spot lesions (WSLs) in patients with fixed orthodontic appliances. The cross-sectional study sample consisted of three groups of patients: group I, 59 patients treated orthodontically for 6 months; group II, 64 patients treated for 12 months; group 0 (control), ...
Kuwaik Ghassan Abu - - 2012
Background: Parental concerns persist that immunization increases the risk of autism spectrum disorder, resulting in the potential for reduced uptake by parents of younger siblings of children with autism spectrum disorder ("younger sibs").Objective: To compare immunization uptake by parents for their younger child relative to their older child with autism ...
Teles Pedro - - 2012
In a wide range of medical fields, technological advancements have led to an increase in the average collective dose in national populations worldwide. Periodic estimations of the average collective population dose due to medical exposure is, therefore of utmost importance, and is now mandatory in countries within the European Union ...
Deravi Leila F - - 2012
Fibronectin (FN) textiles are built as nanometer-thick fabrics. When uniaxially loaded, these fabrics exhibit a distinct threshold between elastic and plastic deformation with increasing stretch. Fabric mechanics are modeled using an eight-chain network and two-state model, revealing that elastic properties of FN depend on conformational extension of the protein and ...
Schaefer Jonathan J - - 2012
Control of permeability of phospholipid vesicle (liposome) membranes is critical to their applications in analytical sensing, in fundamental studies of chemistry in small volumes, and in encapsulation and release of payloads for site-directed drug delivery. Applications of liposome formulations in drug delivery often take advantage of the enhanced permeability of ...
Bernasconi Andrea - - 2012
Amorphous materials became significantly important and more widely studied during the last few decades, due the their increasingly spread applications in materials science and technology. Their local structure seems to have a very strong bond with those properties: in this paper, the local structure of Si-Al-Ca-Na-O glasses is studied by ...
Li Hongyu - - 2012
Excitotoxicity induced by NMDA receptor-mediated intracellular Ca(2+) ([Ca(2+) ](i) ) overload is a major cause of delayed neuronal death in cerebral ischemia. Transient receptor potential canonical (TRPC) 6 protects neurons from ischemic brain damage. However, the mechanisms by which TRPC6 protects neurons are largely unknown. Here, we reported that TRPC6 ...
Yang Tie-Lin - - 2012
Osteoporosis is characterized by low bone mineral density (BMD), a highly heritable trait that is determined, in part, by the actions and interactions of multiple genes. While an increasing number of genes have been identified to have independent effects on BMD, few studies have been performed to identify genes that ...
Hendricks Mark P - - 2012
We describe the synthesis of cadmium bis-(diphenyldithiophosphinate) (Cd(S(2)PPh(2))(2)) from secondary phosphine sulfides and its conversion to cadmium sulfide nanocrystals. Heating Cd(S(2)PPh(2))(2) and cadmium tetradecanoate (≥4 equiv.) to 240 ˚C results in complete conversion of Cd(S(2)PPh(2))(2) to cadmium sulfide nanocrystals with tetradecanoate surface termination. The nanocrystals have a narrow size distribution ...
Maglic D - - 2012
Our recent study showed critical roles of Dmp1 as a sensor of oncogenic Ras, HER2/neu signaling and activation of the Arf-p53 pathway. To elucidate the role of human DMP1 (hDMP1) in breast cancer, one hundred and ten pairs of human breast cancer specimen were studied for the alterations of the ...
Dhakshinamoorthy Amarajothi - - 2012
Metal-organic frameworks (MOFs) are porous crystalline materials that have promising applications as heterogeneous catalysts. After describing the composition, textural properties and crystal structure of four commercially available MOFs, we summarize organic transformations for which these commercial MOFs exhibit higher catalytic activity than the corresponding soluble metal salts or metal ion-exchanged ...
Leroux Robin A - - 2012
Management of the critically endangered hawksbill turtle in the Wider Caribbean (WC) has been hampered by knowledge gaps regarding stock structure. We carried out a comprehensive stock structure re-assessment of 11 WC hawksbill rookeries using longer mtDNA sequences, larger sample sizes (N = 647), and additional rookeries compared to previous ...
Kiyohara Syunsuke - - 2012
Plants contain numerous CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION (ESR) (CLE) genes encoding small secreted peptide hormones that function in a variety of developmental and physiological processes. The first known Arabidopsis CLE gene was originally discovered through the analysis of clv3 mutants, which exhibit fasciated stems and an increased number of floral ...
An Yong Jin - - 2012
The roles of sir-2.1 in C. elegans lifespan extension have been subjects of recent public and academic debates. We applied an efficient workflow for in vivo(13)C-labeling of C. elegans and (13)C-heteronuclear NMR metabolomics to characterizing the metabolic phenotypes of the sir-2.1 mutant. Our method delivered sensitivity 2 orders of magnitude ...
Kramann Rafael - - 2012
Many therapeutic strategies for end-stage renal disease (ESRD) patients have failed to exhibit survival improvement in large-scale randomized controlled trials (RCTs). The current review gives an overview on the medical strategies for treatment of ESRD patients that have previously been tested in RCTs with mortality reduction as pre-specified study endpoint. ...
Lundkvist M - - 2012
BACKGROUND: A small proportion of multiple sclerosis (MS) patients treated with natalizumab develop anti-drug antibodies. OBJECTIVE: The objective of this paper is to characterize the anti-natalizumab antibody response and to investigate differences between persistently and transiently antibody-positive patients. METHODS: Screening for anti-natalizumab antibodies was performed using a standardized bridging ELISA. ...
Koohbanani Bianca - - 2012
This institutional retrospective review studied Ewing sarcomas from 1987-2011. Among 135 patients, 127 (19 Hispanic and 108 white/non-Hispanic) were analyzed (excluding small sample sized groups) finding 15% Hispanic, 85% non-Hispanic, 27% <18 years, 21% >40 years and 1-272 months follow-up (median 41). Age was significantly associated with overall survival (OS) (p = ...
Sowerby Leigh J - - 2012
BACKGROUND: Endoscopic anterior skull-base surgery has been previously suggested to cause a significant deterioration in olfactory function. Given the impact on quality of life, the objective of this study was to determine the effect of a unilateral middle-turbinate-sacrificing approach on olfactory function and sinonasal outcome. METHODS: Prospective cohort study comparing ...
Rudmik Luke - - 2012
BACKGROUND: Topical therapies have become an integral component in the management plan for chronic rhinosinusitis (CRS). Several topical therapy strategies have been evaluated, but a formal comprehensive evaluation of the evidence has never been performed. The purpose of this article is to provide an evidence-based approach for the utilization of ...
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