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Tamang David L DL Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, - - 2012
A feature shared by many inflammatory lung diseases is excessive neutrophilic infiltration. Neutrophil homing to airspaces involve multiple factors produced by several distinct cell types. Hepoxilin A(3) is a neutrophil chemoattractant produced by pathogen-infected epithelial cells that is hypothesized to facilitate neutrophil breach of mucosal barriers. Using a Transwell model ...
Tauseef Mohammad M Department of Pharmacology, 2 Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 61605, - - 2012
Lung vascular endothelial barrier disruption and the accompanying inflammation are primary pathogenic features of acute lung injury (ALI); however, the basis for the development of both remains unclear. Studies have shown that activation of transient receptor potential canonical (TRPC) channels induces Ca(2+) entry, which is essential for increased endothelial permeability. ...
Shin Kyung-Min - - 2012
ABSTRACT: BACKGROUND: Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have adverse side effects and poor adherence. The purpose of this study is to evaluate the effects of moxibustion on blood pressure in individuals with pre- ...
Kim Ansoon - - 2012
Simple and rapid detection of trace amounts of melamine in milk products has been achieved with a portable sensor system based on surface-enhanced Raman scattering (SERS). The sensor system comprised high performance gold nanofinger SERS sensor chips and a custom-built prototype portable Raman spectrometer. Compared to the FDA procedure and ...
Advani Ranjana H - - 2012
PURPOSESurvival and progression of mature B-cell malignancies depend on signals from the B-cell antigen receptor, and Bruton tyrosine kinase (BTK) is a critical signaling kinase in this pathway. We evaluated ibrutinib (PCI-32765), a small-molecule irreversible inhibitor of BTK, in patients with B-cell malignancies. PATIENTS AND METHODSPatients with relapsed or refractory ...
Balogh Dora - - 2012
Au nanoparticles (NPs) are functionalized with chiral (R) or (S) binaphthol phenylboronic acid ligands, (1a) or (1b). The (R)- or (S)-binaphthol phenylboronic acid ligands form donor-acceptor complexes with the chiral dicationic helicene, helquat (P)-HQ2+ or (M)-HQ2+, (2a) or (2b). The association constants between (1a)/(2a) and (1a)/(2b) correspond to (7.0 ± ...
Magariños Marta - - 2012
This is a review of the biological processes and the main signaling pathways required to generate the different otic cell types, with particular emphasis on the actions of insulin-like growth factor I. The sensory organs responsible of hearing and balance have a common embryonic origin in the otic placode. Lineages ...
Green Steven H - - 2012
The spiral ganglion neurons (SGNs) are the afferent neurons of the cochlea, connecting the auditory sensory cells-hair cells-to the brainstem cochlear nuclei. The neurotrophins neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) are expressed in the cochlea and both support SGN survival during development. These neurotrophins remain expressed in the postnatal ...
Guo Changcun C The Preston Robert Tisch Brain Tumor Center at Duke, Pediatric Brain Tumor Foundation Institute, cDepartment of Pathology, Duke University, Durham, NC 27710, - - 2012
Myeloid/lymphoid or mixed-lineage leukemia (MLL)-family genes encode histone lysine methyltransferases that play important roles in epigenetic regulation of gene transcription. MLL genes are frequently mutated in human cancers. Unlike MLL1, MLL2 (also known as ALR/MLL4) and its homolog MLL3 are not well-understood. Specifically, little is known regarding the extent of ...
Ramakrishnan Vijay R - - 2012
BACKGROUND: The frequency of endoscopic sinus surgery (ESS) appears to be increasing, and the use of image-guided surgery (IGS) in these procedures is becoming more widespread. The use of IGS in ESS and anterior skull base surgery is predicated on the notion that its ability to aid in anatomic identification ...
Veghte Daniel P - - 2012
It is currently unknown whether mineral dust causes a net warming or cooling effect on the climate system. This uncertainty stems from the varied and evolving shape and composition of mineral dust, which leads to diverse interactions of dust with solar and terrestrial radiation. To investigate these interactions, we have ...
Fahimi Jahan - - 2012
OBJECTIVE:To evaluate trends in and factors associated with computed tomography (CT) use among children presenting to the emergency department (ED) with abdominal pain.METHODS:This study was a cross-sectional, secondary analysis of the National Hospital Ambulatory Medical Care Survey data from 1998 to 2008. We identified ED patients aged <19 years with ...
Jason Janine - - 2012
BACKGROUND:Invasive Cronobacter infection is rare, devastating, and epidemiologically/microbiologically linked to powdered infant formulas (PIFs). In 2002-2004, the US Food and Drug Administration advised health care professionals to minimize PIF and powdered human milk fortifier (HMF)'s preparation, feeding, and storage times and avoid feeding them to hospitalized premature or immunocompromised neonates. ...
Gautam Rupali - - 2012
Background: The great toe helps in maintaining body balance during standing, walking, running, dancing, and so on.Case Description and Methods: A 22 year-old female patient reported to the department, one month after losing her left hallux in a road accident. Anatomical reconstruction was performed with distraction osteogenesis. The prosthesis was ...
Körmendy Dezsö - - 2012
OBJECTIVE: The importance of the co-stimulatory molecules CD28 and CTLA-4 in the pathological mechanism of Rheumatoid Arthritis (RA) is well documented by genetic associations and the successful clinical application of CTLA-4Ig for the treatment of RA. Here we have investigated the role of the CD28/CTLA-4 axis for the local application ...
Shum C K Y - - 2012
Neuroblastoma (NB) is an embryonal tumor and possesses a unique propensity to exhibit either a spontaneous regression or an unrestrained growth. However, the underlying mechanism for this paradoxical clinical outcome remains largely unclear. Quantitative RT-PCR analysis on 102 primary NB tumors revealed that lower Krüppel-like factor 4 (KLF4) expression is ...
Maclean Glenn A - - 2012
Trisomy 21 is associated with hematopoietic abnormalities in the fetal liver, a preleukemic condition termed transient myeloproliferative disorder, and increased incidence of acute megakaryoblastic leukemia. Human trisomy 21 pluripotent cells of various origins, human embryonic stem (hES), and induced pluripotent stem (iPS) cells, were differentiated in vitro as a model ...
Zhang Shen - - 2012
Radical polymerization from a single initiator molecule in a microenvironment is a nearly ideal system in which bimolecular termination, solution concentration, and viscosity changes could be neglected. In this study, we provide two facile methods of preparing polymers via atom-transfer radical polymerization (ATRP) under single-initiator conditions: tether initiators on planar ...
Kolb Bryan - - 2012
The prefrontal cortex (PFC) receives input from all other cortical regions and functions to plan and direct motor, cognitive, affective, and social behavior across time. It has a prolonged development, which allows the acquisition of complex cognitive abilities through experience but makes it susceptible to factors that can lead to ...
Terashima Mia - - 2012
Cyclic photosynthetic electron flow (CEF) is crucial to photosynthesis because it participates in the control of chloroplast energy and redox metabolism, and it is particularly induced under adverse environmental conditions. Here we report that down-regulation of the chloroplast localized Ca(2+) sensor (CAS) protein by an RNAi approach in Chlamydomonas reinhardtii ...
Carhart-Harris Robin L RL To whom correspondence should be addressed; Imperial College London, Centre for Neuropsychopharmacology, Burlington Danes Building, 160 Du Cane Rd, London, UK. - - 2013
Psilocybin is a classic psychedelic and a candidate drug model of psychosis. This study measured the effects of psilocybin on resting-state network and thalamocortical functional connectivity (FC) using functional magnetic resonance imaging (fMRI). Fifteen healthy volunteers received intravenous infusions of psilocybin and placebo in 2 task-free resting-state scans. Primary analyses ...
Highstein Stephen M SM Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA. - - 2012
This article reviews the structure function of the vestibular system and its pathology with respect to requirements for the design and construction of a functional vestibular prosthesis. The ultimate goal of a vestibular prosthesis is to restore balance and equilibrium through direct activation of vestibular nerve fibers. An overview of ...
Hardy Sam A - - 2012
OBJECTIVES: This study examined the roles of identity formation and moral identity in predicting college student mental health (anxiety and depressive symptoms), health-risk behaviors (hazardous alcohol use and sexual risk taking), and psychological well-being (self-esteem and meaning). METHOD: The sample comprised 9,500 college students (aged 18-25 years, mean = 19.78, standard ...
Touwslager Robbert N H - - 2012
Low birth weight and accelerated infant growth are associated with cardiovascular disease in adulthood. Endothelial dysfunction is regarded as a precursor of atherosclerosis and is also related to infant growth. We aimed to examine whether an association between infant growth and endothelial function is already present during discrete periods of ...
Sabatinos Sarah A - - 2012
Hydroxyurea (HU) treatment activates the intra-S phase checkpoint proteins Cds1 and Mrc1 to prevent replication fork collapse. We found that prolonged DNA synthesis occurs in cds1Δ and mrc1Δ checkpoint mutants in the presence of HU and continues after release. This is coincident with increased DNA damage measured by phosphorylated histone ...
Pea Federico - - 2012
The worrisome increase in Gram-negative bacteria with borderline susceptibility to carbapenems and of carbapenemase-producing Enterobacteriaceae has significantly undermined their efficacy. Continuous infusion may be the best way to maximize the time-dependent activity of meropenem. The aim of this study was to create dosing nomograms in relation to different creatinine clearance ...
Marshall Janice M JM School of Clinical & Experimental Medicine, College of Medical & Dental Sciences, The Medical School, Vincent Drive, University of Birmingham, Birmingham B15 2TT, UK. - - 2012
This review considers the contributions to exercise hyperaemia of substances released into the interstitial fluid, with emphasis on whether they are endothelium dependent or O(2) dependent. The early phase of exercise hyperaemia is attributable to K(+) released from contracting muscle fibres and acting extraluminally on arterioles. Hyperpolarization of vascular smooth ...
Lucchese Alessandra - - 2012
SummaryThe aim of the study was to determine the prevalence of white-spot lesions (WSLs) in patients with fixed orthodontic appliances. The cross-sectional study sample consisted of three groups of patients: group I, 59 patients treated orthodontically for 6 months; group II, 64 patients treated for 12 months; group 0 (control), ...
Darmon Jonathan M - - 2012
Addition of biphenylene to the bis(imino)pyridine iron dinitrogen complexes, ((iPr)PDI)Fe(N(2))(2) and [((Me)PDI)Fe(N(2))](2)(μ(2)-N(2)) ((R)PDI = 2,6-(2,6-R(2)-C(6)H(3)-N═CMe)(2)C(5)H(3)N; R = Me, (i)Pr), resulted in oxidative addition of a C-C bond at ambient temperature to yield the corresponding iron biphenyl compounds, ((R)PDI)Fe(biphenyl). The molecular structures of the resulting bis(imino)pyridine iron metallacycles were established by ...
Kuwaik Ghassan Abu - - 2012
Background: Parental concerns persist that immunization increases the risk of autism spectrum disorder, resulting in the potential for reduced uptake by parents of younger siblings of children with autism spectrum disorder ("younger sibs").Objective: To compare immunization uptake by parents for their younger child relative to their older child with autism ...
Drnevich Jenny J Carver Biotechnology Center and High-Performance Biological Computing Group, University of Illinois at Urbana-Champaign, Urbana, IL 61801, - - 2012
Songbirds provide rich natural models for studying the relationships between brain anatomy, behavior, environmental signals, and gene expression. Under the Songbird Neurogenomics Initiative, investigators from 11 laboratories collected brain samples from six species of songbird under a range of experimental conditions, and 488 of these samples were analyzed systematically for ...
Eshraghi Adrien A - - 2012
This review covers the most recent clinical and surgical advances made in the development and application of cochlear implants (CIs). In recent years, dramatic progress has been made in both clinical and basic science aspect of cochlear implantation. Today's modern CI uses multi-channel electrodes with highly miniaturized powerful digital processing ...
Maskatia Shiraz A - - 2012
OBJECTIVES: Evaluate the incidence of various morphologic types of congenital AS, and the association between valve morphology and long-term outcomes, including repeat BAV, AVR, and death/transplant. BACKGROUND: Reports on long-term outcomes have low agreement on the influence of morphologic type. METHODS: We queried our institutional database and hospital billing records ...
Duijts Saskia F A - - 2012
PURPOSEThe purpose of our study was to evaluate the effect of cognitive behavioral therapy (CBT), physical exercise (PE), and of these two interventions combined (CBT/PE) on menopausal symptoms (primary outcome), body image, sexual functioning, psychological well-being, and health-related quality of life (secondary outcomes) in patients with breast cancer experiencing treatment-induced ...
Wilgenhof Sofie - - 2012
Ipilimumab 3 mg/kg was the first agent to improve survival of pretreated advanced melanoma patients. Nonconventional response patterns to ipilimumab have been reported widely, but most of these data were from studies with ipilimumab 10 mg/kg. Here, case reports from five patients treated within an expanded access program (EAP) with ...
Angeli Simon S Department of Otolaryngology, University of Miami, Miami, Florida 33136, - - 2012
This article is a review of the genes and genetic disorders that affect hearing in humans and a few selected mouse models of deafness. Genetics is playing an increasingly critical role in the practice of medicine. This is not only in part to the importance that genetic knowledge has on ...
Chen Tong - - 2012
Two kinds of core-shell structured multifunctional nanocarriers of gold nanoclusters (Au NCs) as core and folate (FA)-conjugated amphiphilic hyperbranched block copolymer as shell based on poly(L-lactide) (PLA) inner arm and FA-conjugated sulfated polysaccharide (GPPS-FA) outer arm (Au NCs-PLA-GPPS-FA) were synthesized for targeted anticancer drug delivery. The structure and properties of ...
Bickston Stephen J - - 2012
Tetomilast is a novel thiazole phosphodiesterase-4 (PDE-4) inhibitor, which may prove useful in both the treatment of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD). Here, the authors review the pharmacology of the drug, and offer critical review of the available data for use of tetomilast in the ...
Van De Water Thomas R - - 2012
This review presents some of the major historical events that advanced the body of knowledge of the anatomy of the inner ear and its sensory receptors as well as the biology of these receptors that underlies the sensory functions of hearing and balance. This knowledge base of the inner ear's ...
Couderc M - - 2012
OBJECTIVE: To study the influence of several factors (rheumatoid factor [RF], anti-cyclic citrullinated peptid [anti-CCP], serum immunoglobulin [Ig] level, Epstein Barr virus [EBV] load) on clinical response to RTX after 6 months in rheumatoid arthritis (RA) patients. METHOD: Sixty-four patients receiving RTX (two 1g doses, 2weeks apart) for active RA ...
Bawa-Khalfe Tasneem T Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. - - 2012
Two Sentrin/small ubiquitin-like modifier (SUMO)-specific protease 7 (SENP7) variants are naturally expressed in breast epithelia. Breast cancer (BCa) onset down-regulates the short SENP7 splice variant (SENP7S) and enhances the long transcript (SENP7L). Here, we show that SENP7L induction promotes gene expression profiles that favor aberrant proliferation and initiate epithelial-mesenchymal transition ...
Hornbeck Thomas T Department of Computer Science, College of Public Health, University of Iowa, Iowa City, Iowa 52242, - - 2012
Super-spreading events, in which an individual with measurably high connectivity is responsible for infecting a large number of people, have been observed. Our goal is to determine the impact of hand hygiene noncompliance among peripatetic (eg, highly mobile or highly connected) healthcare workers compared with less-connected workers. We used a ...
Hentrich Marcus - - 2012
Although the outcome of patients with HIV-related Hodgkin lymphoma (HIV-HL) has markedly improved since the introduction of combined antiretroviral therapy, standard therapy is still poorly defined. This prospective study investigates a stage- and risk-adapted treatment strategy in patients with HIV-HL. Patients with early favorable HIV-HL received two to four cycles ...
Finke Aaron D - - 2012
We present an investigation of the electronic properties and reactivity behavior of electron-accepting 6,6-dicyanopentafulvenes (DCFs). The EPR spectra of the radical anion of a tetrakis(silylalkynyl) DCF, generated by Na metal reduction, show delocalization of both the charge and unpaired electron to the nitrogens of the cyano moieties and also, notably, ...
Hjalmarson Helene Victoria - - 2012
The aim of this study was to explore the development of interprofessional collaboration aiming to improve secondary prevention of osteoporosis by studying this topic expansively from the perspectives of different stakeholders. The method used was a longitudinal single case study with both qualitative and quantitative data sources. The findings elucidate ...
Cheung Carol Yim-Lui - - 2012
The retinal vasculature allows direct noninvasive visualization of the body's mircrovasculature. Because the retina and other end organs (brain and kidney) share similar anatomical features and physiological properties, the retinal vessels offer a unique and easily accessible window to study the health and disease of the human microcirculation. Advanced retinal ...
Blancafort Lluís - - 2012
Hyperconjugation and its relation with the 1,2-shift rearrangement reactivity in bicyclo[2.1.0]pentane and cyclopropane radical cations has been studied with density functional theory (PBE0/6-311G**). Hyperconjugation has been evaluated by calculating the 1H hyperfine coupling constants, atomic spin densities, and dihedral angles of β hydrogens with respect to the axes of the ...
Andreychenko A - - 2012
Application of travelling wave MR to human body imaging is restricted by the limited peak power of the available RF amplifiers. Nevertheless, travelling wave MR advantages like a large field of view excitation and distant location of transmit elements would be desirable for whole body MRI. In this work, improvement ...
Burger Ian - - 2012
Respiratory motion is a major problem in cardiac MRI. In this work, the displacement of the heart relative to the diaphragm was investigated. A subject-specific nonlinear elliptical affine model has been developed to incorporate the effect of hysteresis in motion correction. Nine healthy volunteers participated in a study in which ...
De Jesus Maria - - 2012
Objectives. To examine predictors of health care service utilization in Mexico or any other country in Latin America among the US Hispanic population. Methods. This study used data from the 2007 Pew Hispanic Healthcare Survey, a nationally representative survey of 4013 Hispanic adults. Using the Behavioral Model of Health Service ...
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