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Results 251 - 300 of 3450
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Feng Ji-Feng - - 2012
Abstract Background. The risk factors for No. 12p and No. 12b lymph node (LN) metastases in advanced gastric cancer (GC) remain controversial. The aim of this study was to investigate the risk factors for No. 12p and No. 12b LN metastases in advanced GC. Methods. From January 1999 to December ...
Freitas F T M - - 2012
SUMMARY In order to estimate influenza-associated excess mortality in southern Brazil, we applied Serfling regression models to monthly mortality data from 1980 to 2008 for pneumonia/influenza- and respiratory/circulatory-coded deaths for all ages and for those aged ⩾60 years. According to viral data, 73·5% of influenza viruses were detected between April ...
Menéndez Aurora - - 2012
Clinical associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies are not yet fully established. In order to analyse the diagnostic utility of their separate detection, we retrospectively revised the clinical data of 200 anti-SSA/Ro60 and/or anti-Ro52/TRIM21 positive patients identified by line immunoassay during ANA routine detection. Anti-SSA/Ro60 positive patients showed a significantly ...
Akaihata Hidenori - - 2012
Purpose: Due to the limited working space available during retroperitoneal laparoscopic radical nephrectomy (LRN), the body habitus of the patient is likely to affect the risk of operative difficulties. This study sought to determine whether anthropometric measurements based on computerized tomography (CT) and abdominal X-ray could be used to predict ...
Xie Yufeng Y Saskatchewan Cancer Agency, Department of Oncology, University of Saskatchewan, Saskatoon, Saskatchewan, - - 2013
The ultimate goal of antitumor vaccines is to develop memory CD8(+) cytotoxic T lymphocytes (CTLs), which are critical mediators of antitumor immunity. We previously demonstrated that the ovalbumin (OVA)-specific CD4(+) T cell-based (OVA-T(EXO)) vaccine generated using OVA-pulsed dendritic cell (DC(OVA))-released exosomes (EXO(OVA)) stimulate CTL responses via IL-2 and costimulatory CD80 ...
Williams Owain D - - 2012
Abstract This study explores how an 'Intellectual Property Rights (IPR)/trade regime' has generated a particular set of problems regarding access to medicines despite patents on drugs being presented as economically necessary for reward and future drug innovation. These problems have also inspired and informed activities by so-called new actors in ...
Cai Yubo - - 2012
Aim:  To provide a profile of second malignant neoplasms (SMN) in patients with childhood primary malignant brain tumour originating from neuroepithelial tissues with latest data in a population-based study. Methods:  Surveillance, Epidemiology, and End Results (SEER) database (1973-2007) was used to identify above-stated patients. SMN patients were further identified, and ...
Song Guang-Yao - - 2012
We perform the present study to investigate the effects of high-fructose-feeding and high-fat-feeding on muscle lipid metabolism and to illustrate the mechanisms by which the two different dietary factors induce muscular lipid accumulation. C57BL/J6 mice were fed a standard, high-fructose (HFru) or high-fat diet. After 16-week feeding, mice were sacrificed ...
Pinto Fátima F - - 2012
BACKGROUND: Kawasaki disease is an acute systemic vasculitis. Cardiac complications are frequent and include endothelial dysfunction in patients with coronary anomalies. So far, the presence of endothelial dysfunction in patients with no coronary lesions has not been demonstrated. Peripheral arterial tonometry (Endo-PAT) measures the microvascular function in response to local ...
Abe Y - - 2012
This study aimed to analyse occlusal force, area and pressure for individual maxillary and mandibular teeth by assessing their occlusal-supporting abilities. Ninety-nine subjects (49 men and 50 women; average age, 24·7 ± 3·4 years; range, 20-37 years) performed maximal voluntary clenching twice for 3 s in both the intercuspal position and the intercuspal position with ...
Torrecilla María - - 2012
Dysfunctional noradrenergic transmission is related to several neuropsychiatric conditions, such as depression. Nowadays, the role of G protein-coupled inwardly rectifying potassium (GIRK)2 subunit containing GIRK channels controlling neuronal intrinsic excitability in vitro is well known. The aim of this study was to investigate the impact of GIRK2 subunit mutation on ...
Jiang Huan - - 2012
Chitosan stabilized silver nanoparticles (Ch-Ag NPs) were successfully synthesized by a one-step method and were found to possess intrinsic peroxidase-like activity, could catalytically oxidize substrates, such as TMB, and OPD, by H(2)O(2) to produce a typical colour reaction such as from colorless to blue for TMB and from colorless to ...
Memari A H - - 2012
What is already known about this subject Individuals with disabilities are more likely to be sedentary compared to the general population. Individuals with ASD show several impairments in motor and physical functioning. Lack of opportunity is the primary factor that brings minimal physical activity to children with ASD. What this ...
Chisholm V - - 2012
BACKGROUND: The incidence of type 1 diabetes is increasing in young children. However, they are overlooked in treatment adherence and intervention research despite evidence that parents often experience difficulty securing their treatment cooperation, especially with the diet. We investigated positive and incongruent (i.e. the co-occurrence of contradictory verbal and non-verbal ...
Alison Laurence - - 2012
This paper examines the extent to which orthodoxy (degree of typicality) and congruence (degree of similarity with own opinion) mediate the influence of expert advice on decision makers' judgments. Overall, 227 members of the public and 60 police officers completed an online questionnaire involving an investigation into a child sex ...
Kangas Maria - - 2012
OBJECTIVE: Head and neck cancer (HNC) patients have a high incidence of cancer-related posttraumatic stress disorder (PTSD) and other anxiety and depressive disorders. We report the results from the first pilot randomized controlled trial in which the efficacy of an early cognitive-behavioral therapy (CBT) program was compared with a non-directive ...
Oketch-Rabah Hellen A - - 2012
ABSTRACT This paper reviews the literature concerning the ethnobotany, phytochemistry, and pharmacology of Mondia whitei, which is also known as Mondia whytei, African ginger or simply as mondia. Mondia is used in many parts of Africa as a traditional remedy to improve appetite and libido, as a galactagogue, as a ...
Kane Nolan C - - 2012
Long a major focus of genetic research and breeding, sunflowers (Helianthus) are emerging as an increasingly important experimental system for ecological and evolutionary studies. Here, we review the various attributes of wild and domesticated sunflowers that make them valuable for ecological experimentation and describe the numerous publicly available resources that ...
Kaya Sadik - - 2012
BACKGROUND: Hair follicle mites, D. folliculorum and D. brevis, are known to accompany immune deficiency states however no study so far has investigated their presence in malnutrition. In this study we aimed to determine the prevalence of those mites in childhood malnutrition and malignancy and risk factors. METHODS: One hundred ...
Laher Ismail - - 2012
Abstract Moderate exercise improves cardiac antioxidant status in young humans and animals with type 2 diabetes (T2D). Given that both diabetes and advancing age synergistically decrease antioxidant expression in most tissues, it is unclear whether exercise can upregulate cardiac antioxidants in chronic animal models of T2D. To this end, 8-month ...
Lee Joon-Suk - - 2012
Ginsenoside Rb1 (GRb1) is a major ingredient of ginseng and has a wide range of neuroprotection effects. Neuroinflammation is a feature of neurodegenerative conditions and is characterized by microglia activation and the expression of major inflammatory mediators. The present study investigated the modulatory effect of GRb1 on microglia activation, the ...
Champion Katrina E - - 2012
ISSUES: The use of alcohol and drugs amongst young people is a serious concern and the need for effective prevention is clear. This paper identifies and describes current school-based alcohol and other drug prevention programs facilitated by computers or the Internet. APPROACH: The Cochrane Library, PsycINFO and PubMed databases were ...
Börzsönyi Balázs - - 2012
Abstract Objective: In this study, we assessed Bcl-2 and Bax gene expression patterns in human placental samples from intrauterine growth restriction (IUGR) pregnancies using normal pregnancy as control. Methods: We compared Bcl-2 and Bax gene expression in placental samples from all IUGR pregnancies treated in our clinic between January 1, ...
Matthews Deborah - - 2012
Patients with Congenital Adrenal Hyperplasia due to partial deficiency in the enzyme 21-hydroxlyase can present in childhood or adolescence with signs of adrenal androgen excess. Strategies to reduce the impact of androgen excess in females include cosmetic measures as well as an anti-androgens and agents such as the combined oral ...
Muraro L - - 2012
An eight-year-old Doberman pinscher was presented with a four-week history of inspiratory stridor, dysphonia, inappetence and weight loss. Inspiratory stridor was apparent and became more pronounced during gentle compression of the larynx. Previous investigations, including laryngoscopy, had revealed the presence of a left-sided arytenoid mass. Histological examination of pinch biopsies ...
Fırat Tüzün - - 2012
BACKGROUND: The aim of this study was to describe the impact of Obstetrical Brachial Plexus Palsy (OBPP) on parents and to investigate the effect of the severity of OBPP and the age of the children on parents. METHODS: A total of 106 parents (with a mean age of 30.14±5.01 years) ...
Helft Julie J Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York 10029, - - 2012
CD8+ cytotoxic T cells are critical for viral clearance from the lungs upon influenza virus infection. The contribution of antigen cross-presentation by DCs to the induction of anti-viral cytotoxic T cells remains controversial. Here, we used a recombinant influenza virus expressing a nonstructural 1-GFP (NS1-GFP) reporter gene to visualize the ...
Chen Y-B - - 2012
Acute intestinal GVHD remains a major source of morbidity after allogeneic hematopoietic cell transplantation (HCT). α4β7 integrin is a cell surface molecule that mediates lymphocyte trafficking to intestinal tissue. In this analysis, peripheral blood was collected at the time of presentation of symptoms of acute GVHD and before any treatment. ...
Cao Jinxin - - 2012
Long aromatic polyamide chains are prepared from the corresponding monomers. The resultant polymer adopts a hollow helical conformation that is stabilized by intramolecular H-bonding interaction between side chains.
Barboiu Mihail - - 2012
Going through the channels: Synthetic scaffolds mimicking natural protein functions have been developed that allow water/proton or only water translocation pathways in bilayer membranes. The ion-exclusion behaviors of the synthetic systems are based on hydrophobic or dimensional steric effects, while hydrodynamic effects appear to be less important.
de Graaf Johanna P - - 2012
Abstract Objective: Analyses of the effects of place of residence, socio-economic status and ethnicity on perinatal mortality and morbidity in the Netherlands. Methods: Epidemiological analysis of all singleton deliveries ≥ 22 gestational weeks (871 889 live born and 5927 stillborn) from the Dutch National Perinatal Registry 2002-2006. Multiple logistic regression ...
Majmudar Chinmay Y CY Department of Chemistry, University of Michigan, Ann Arbor, - - 2012
Capturing a coactivator, naturally: the natural products sekikaic acid and lobaric acid, isolated after a high-throughput screen of a structurally diverse extract collection, effectively target the dynamic binding interfaces of the GACKIX domain of the coactivator CBP/p300. These molecules are the most effective inhibitors of the GACKIX domain yet described ...
Zhang Guoqi - - 2012
A cationic cobalt(II)-alkyl complex is an effective precatalyst for hydrogenation of alkenes, aldehydes, ketones, and imines under mild conditions (1-4 atm H(2) ; see scheme). The catalyst shows a high functional-group tolerance across a broad range of substrates. Experiments suggest that the active catalytic species is a cobalt(II)-hydride complex.
Shimada Mai - - 2012
Introduction The objective of this study was to determine the resource utilization of a tertiary care Japanese emergency department (ED) that was not immediately adjacent to the area of the 2011 Great East Japan earthquake and tsunami. METHODS: A retrospective chart review was performed at a tertiary care university-based urban ...
Mantelli D - - 2012
We evaluate the chemical potential of a one-dimensional quantum dot coupled to an atomic force microscope tip. The dot is described within the Luttinger liquid framework, and the conductance peak positions as a function of the tip location are calculated in the linear and non-linear transport regimes for an arbitrary ...
Callaerts-Vegh Z - - 2012
Lysophosphatidic acid (LPA) is a bioactive lipid acting on the nervous system through at least 6 different G protein-coupled receptors. In this study, we examined mice lacking the LPA(5) receptor using an extensive battery of behavioral tests. LPA(5) -deficient mice showed decreased pain sensitivity in tail withdrawal, faster recovery in ...
Mallick Emily M - - 2012
Enterohemorrhagic E. coli (EHEC) is an important subset of Shiga toxin-producing (Stx-producing) E. coli (STEC), pathogens that have been implicated in outbreaks of food-borne illness and can cause intestinal and systemic disease, including severe renal damage. Upon attachment to intestinal epithelium, EHEC generates "attaching and effacing" (AE) lesions characterized by ...
Bubonja-Sonje Marina - - 2012
Abstract Background: Listeria monocytogenes usually causes mild maternal illness, but can be devastating to the fetus. Case: Listeriosis in a pregnant patient successfully treated with empiric antibiotic therapy is described. After induced delivery, despite severe placental infection, a healthy infant was born. Additionally, archived placental specimens with similar pathological manifestation ...
Ochola Sophie A - - 2012
OBJECTIVE: To determine the impact of facility-based semi-intensive and home-based intensive counselling in improving exclusive breast-feeding (EBF) in a low-resource urban setting in Kenya. DESIGN: A cluster randomized controlled trial in which nine villages were assigned on a 1:1:1 ratio, by computer, to two intervention groups and a control group. ...
Wu Jilong - - 2012
Cell-mediated autoimmunity has been suggested to be involved in the melanocyte apoptosis that occurs in vitiligo. We investigated the cytotoxicity to autologous melanocytes of CD8+ T cells from the perilesional margins and peripheral blood samples of vitiligo patients. CD8+ T cells isolated from skin biopsied from the edges of depigmented skin patches ...
Holopainen Gunilla - - 2012
Encounters in relation to the nurse-patient relationship are often discussed within nursing and caring literature without a reflection on the actual meaning of the concept. Assuming that an encounter is essential for nursing care, this article seeks to create a deeper understanding of the concept through a hermeneutic approach to ...
Li Ming - - 2012
The 3,3'-bioxindole derivatives were constructed in a single step via an efficient Rh(2)(OAc)(4) catalyzed reaction of diazoacetamides with isatins. This novel method provides an alternative pathway towards 3-hydroxy-3,3'-bioxindoles in good yield (up to 78%) with high diastereoselectivity (up to 95 : 5).
Wang Bo - - 2012
We synthesized a diosgenyl saponin bearing a unique disaccharide from the natural product β-hederin, together with twelve glycosylated derivatives and determined their cytotoxicity against five different human cancer cell lines. Most of them showed weak cytotoxicity, with the exception of compound , diosgenyl α-l-rhamnopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→4)]-α-l-arabinopyranoside, which exhibited strong cytotoxicity against A549 ...
Sumi A - - 2012
SUMMARY Rotavirus is a common viral cause of severe diarrhoea. For the underlying cause of rotavirus seasonality, the meteorological factor has been suspected, whereas quantitative correlation between seasonality and meteorological factor has not been fully investigated. In this study, we investigated the correlation of temporal patterns of the isolation rate ...
Czepa D - - 2012
Episodes of bleeding in people with haemophilia (PWH) are associated with reduced activity and limitations in physical performance. Within the scope of the 'Haemophilia & Exercise Project' (HEP) PWH were trained in a sports therapy programme. Aim of this study was to investigate subjective and objective physical performance in HEP-participants ...
Utter Jennifer - - 2012
Aim:  The study aims to describe the prevalence of weight loss behaviours and weight-related concerns among a nationally representative sample of adolescents in New Zealand. Methods:  Data for this study were collected as part of Youth'07, a nationally representative survey of the health and well-being of 9107 secondary school students ...
Rothschild C - - 2012
Immune tolerance induction (ITI) can eliminate factor VIII (FVIII) inhibitory antibodies that appear during FVIII replacement therapy. If first-line ITI fails, switching to a different FVIII concentrate, especially one containing von Willebrand factor (VWF), has been advocated. The objective of the study was to assess the efficacy and safety of ...
Clauzier Stephanie - - 2012
Hydrogen solubility at 298 K and 30 bar in hybrid sorbents consisting of n-hexane confined in MIL-101 is found to be 22 times larger than in sole n-hexane. The enhanced solubility in MIL-101, found to be 3 times larger than in mesoporous silica of similar pore size, highlights the key ...
Almajan Eva R - - 2012
Mutations in the AFG3L2 gene have been linked to spinocerebellar ataxia type 28 and spastic ataxia-neuropathy syndrome in humans; however, the pathogenic mechanism is still unclear. AFG3L2 encodes a subunit of the mitochondrial m-AAA protease, previously implicated in quality control of misfolded inner mitochondrial membrane proteins and in regulatory functions ...
Sochol Ryan D - - 2012
Precision hydrodynamic controls of microparticles (e.g., microbeads and cells) are critical to diverse lab-on-a-chip applications. Microfluidic particulate-based arraying techniques are widely used; however, achieving full microarray resettability without sacrificing trapping performance has remained a significant challenge. Here we present a single-layer hydrodynamic methodology for releasing high numbers of microparticles after ...
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