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Results 201 - 250 of 3450
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Pei Cheng-Kui - - 2012
Tell me which you want: Catalytic asymmetric [4+2] cycloadditions of β,γ-unsaturated α-ketophosphonates with allenic esters catalyzed by organocatalysts derived from different cinchona alkaloids have been developed, affording phosphonate-substituted functionalized pyran and dihydropyran derivatives in excellent yields with high enantioselectivities under mild conditions. The choice of product is controlled by the ...
Rentsch Andreas - - 2012
Leading the way: The synthesis of natural products with new biological targets is one of the driving forces for the development of new antibiotics. The synthesis of the two secondary metabolites corallopyronin and myxopyronin have been achieved, which are prominent leads for the inhibition of bacterial RNA polymerase.
Xin Yong-Ning - - 2012
A missense mutation I148M in PNPLA3 (patatin-like phospholipase domain-containing 3 protein) is significantly correlated with nonalcoholic fatty liver disease. To glean insights into mutation's effect on enzymatic activity, we performed molecular dynamics simulation and flexible docking studies. Our data shows that the size of the substrate-access entry site is significantly ...
Xiong Yi - - 2012
Abstract Objective: To evaluate the feasibility of live xPlane imaging visualizing the in-plane view of IVS in the screening of the fetal conotruncal anomalies. Method: One hundred and fifty-two consecutive normal singleton fetuses and forty-eight fetal cardiac defects (27 conotruncal and 21 non-conotruncal cases), were enrolled in this study. The ...
Fouladi Rohollah F - - 2012
ABSTRACT Berberis vulgaris L. (barberry) is a very well-known herb in traditional medicine. Apart from its anti-inflammatory and antibacterial properties, the antilipogenic effect of barberry on the sebaceous glands in animals may further suggest it could be employed as an anti-acne agent. This study examined the effect of oral aqueous ...
Sato M - - 2012
Various biomarkers have been investigated with regard to their ability to predict the outcome of allogeneic hematopoietic SCT (HSCT). In this study, we retrospectively reviewed 90 recipients who received HSCT between 2007 and 2011 in our institution, and evaluated the predictive value of the baseline serum C-reactive protein (CRP) levels ...
Kim Min - - 2012
Postsynthetic ligand and metal ion exchange (PSE) processes are shown to readily occur in several 'inert' metal-organic frameworks (MOFs), including zeolitic imidazolate frameworks (ZIFs). Ligand exchange can occur between solid samples, as was demonstrated under relatively mild conditions with two robust, topologically distinct MOFs, MIL-53(Al) and MIL-68(In) (MIL = Materials ...
Kumar Pawan - - 2012
Synthesis of three pyrene modified nucleosides was accomplished using the CuAAC reaction. Hereby, pyrene is attached either to the 5'-position of thymidine or to the 2'-position of 2'-deoxyuridine through triazolemethylene linkers, or to the 2'-position of 2'-deoxyuridine through a more rigid triazole linker. The three nucleosides were incorporated into oligonucleotides ...
Power Brian D - - 2012
Objective:Whilst cannabis has been associated with an earlier age at onset in schizophrenia, the impact of amphetamine and/or cocaine plus cannabis consumption on age at onset remains unclear. The present study was designed to test the hypothesis that consumption of amphetamine and/or cocaine in addition to cannabis would lead to ...
Tempel Wolfram - - 2012
Overexpression of multiple copies in T-cell lymphoma-1 (MCT-1) oncogene accompanies malignant phenotypic changes in human lymphoma cells. Specific disruption of MCT-1 results in reduced tumorigenesis, suggesting a potential for MCT-1-targeted therapeutic strategy. MCT-1 is known as a cap-binding protein and has a putative RNA-binding motif, the PUA-domain, at its C-terminus. ...
Majka Andrew J - - 2012
A unique quality improvement (QI) curriculum was implemented within the Division of General Internal Medicine to improve QI knowledge through multidisciplinary, team-based education, which also met the QI requirement for the American Board of Internal Medicine (ABIM) Maintenance of Certification (MOC) and the Mayo Quality Fellows program. Participants completed up ...
Deporter Douglas - - 2012
OBJECTIVE: This study was undertaken to assess short, sintered porous-surfaced (SPS), press-fit implants with mandibular overdentures to restore edentulous patients with severe mandibular resorption. MATERIALS AND METHODS: Implant lengths of 7, 8, 9, and 10 mm were used, all with 2-mm polished collars, making the designed intrabony lengths 5, 6, 7, ...
Suaid Flávia A - - 2012
OBJECTIVE: The aim of this study was to evaluate the buccal bone plate remodeling after immediate implantation using the flapless approach with or without bone graft into the gap between the implant and the buccal bone. MATERIAL AND METHODS: Eight dogs had the mandibular bicuspids extracted without flaps, and four ...
Alquraishi Mohammed - - 2012
The energetics of protein-DNA interactions are often modeled using so-called statistical potentials, that is, energy models derived from the atomic structures of protein-DNA complexes.Many statistical protein-DNA potentials based on differing theoretical assumptions have been investigated, but little attention has been paid to the types of data and the parameter estimation ...
Flohil S C - - 2012
Background  In the Netherlands basal cell carcinomas (BCC) are eligible for Mohs microscopic surgery (MMS) if certain criteria are fulfilled. Objective  To study the MMS indication criteria practised at the department of dermatology of the Erasmus University Medical Center, Rotterdam and to identify predictive factors for extensive subclinical tumour spread ...
Méhes Gábor - - 2012
Make your OLED fluorescent: An aromatic molecule based on a spiro-acridine derivative was designed, and its photoluminescence and electroluminescence were characterized. By combining the donor and acceptor moieties a small energy gap between the lowest singlet and triplet states was achieved. This design leads to an organic light-emitting diode (OLED) ...
Peter Emanuel - - 2012
The spatio-temporal control of gene expression is fundamental to elucidate cell proliferation and deregulation phenomena in living systems. Novel approaches based on light-sensitive multi-protein complexes have recently been devised, showing promising perspectives for the noninvasive and reversible modulation of the DNA-transcriptional activity in vivo. This has lately been demonstrated in ...
Hernández-Mijares A - - 2012
OBJECTIVE: Subclinical hypothyroidism (SCH) is a common condition associated with increased cardiovascular risk. A standard treatment is yet to be established, as there is no consensus on the TSH cut-off values which should be used as indicators. Thus, the aim of this study was to assess cardiovascular risk in patients ...
Wang Shan - - 2012
Streptomyces sahachiroi ATCC 33158 produces the potent antitumor antibiotic azinomycin B which is featured with a set of unusual functionalized moieties. However, the genetic analyses of azinomycin B biosynthetic pathway are hampered by the low efficiency of S. sahachiroi genetic manipulation. In the present study, we developed two efficient DNA ...
Barboiu Mihail - - 2012
Going through the channels: Synthetic scaffolds mimicking natural protein functions have been developed that allow water/proton or only water translocation pathways in bilayer membranes. The ion-exclusion behaviors of the synthetic systems are based on hydrophobic or dimensional steric effects, while hydrodynamic effects appear to be less important.
de Graaf Johanna P - - 2012
Abstract Objective: Analyses of the effects of place of residence, socio-economic status and ethnicity on perinatal mortality and morbidity in the Netherlands. Methods: Epidemiological analysis of all singleton deliveries ≥ 22 gestational weeks (871 889 live born and 5927 stillborn) from the Dutch National Perinatal Registry 2002-2006. Multiple logistic regression ...
Varcabová Sárka - - 2012
The present study was undertaken to evaluate the hypothesis that the antihypertensive action of soluble epoxide hydrolase (sEH) inhibition is mediated by an increased availability in intrarenal epoxyeicosatrienoic acids (EETs) with consequent improvement of renal haemodynamic autoregulatory efficiency and of the pressure-natriuresis relationship. Ren-2 transgenic rats (TGR), a model of ...
Wang Chuanxi - - 2012
Fluorescent gold nanodots (GNDs) are an important kind of nanoprobes. Herein, the application of galvanic replacement for the preparation of fluorescent GNDs is reported. Using presynthesized and size-controlled Ag nanodots (Ag NDs) as templates, the as-prepared GNDs have strong fluorescence (quantum yields ∼10%) with high stability and surface bioactivity. The ...
Capici Calogero - - 2012
The stepwise synthesis of ionizable p-tert-butylcalix[5]arenes 1a∙H and 1b∙H, featuring a fixed cone cavity endowed with a carboxyl moiety at the narrow rim, is described. Single crystal X-ray analyses have shown that in the solid state 1a∙H and 1b∙H adopt a cone-out conformation with the carboxylic OH group pointing in, ...
Sznajd J - - 2012
The finite field para-ferrimagnetic phase transition in the axial next-nearest-neighbor Ising (ANNNI) model is studied by using the linear perturbation real space renormalization group transformation. The method is examined in systems of ferromagnetic and antiferromagnetic Ising chains coupled by ferromagnetic interactions in the longitudinal field. As one would expect, the ...
Chedraui Peter - - 2012
Abstract Objective: To measure plasma nitric oxide (NO), asymmetric dimethylarginine (ADMA) and vascular endothelial growth factor (VEGF) levels and VEGF gene polymorphisms in fetal circulation in severe preeclampsia. Methods: Cord vessels of singleton gestations complicated with severe preeclampsia 36 weeks or more (n=31) and controls were sampled upon delivery for ...
Suzuki Kan - - 2012
Plasma citrulline has been reported to be a good indicator of intestinal functional volume in patients with intestinal dysfunction. We reconfirmed the facts and also investigated the dynamic changes of plasma citrulline in acute phase patients with intestinal dysfunction. MATERIALS AND METHODS: We measured plasma citrulline in 6 patients with ...
Li Ming - - 2012
The 3,3'-bioxindole derivatives were constructed in a single step via an efficient Rh(2)(OAc)(4) catalyzed reaction of diazoacetamides with isatins. This novel method provides an alternative pathway towards 3-hydroxy-3,3'-bioxindoles in good yield (up to 78%) with high diastereoselectivity (up to 95 : 5).
Wang Bo - - 2012
We synthesized a diosgenyl saponin bearing a unique disaccharide from the natural product β-hederin, together with twelve glycosylated derivatives and determined their cytotoxicity against five different human cancer cell lines. Most of them showed weak cytotoxicity, with the exception of compound , diosgenyl α-l-rhamnopyranosyl-(1→2)-[α-l-arabinopyranosyl-(1→4)]-α-l-arabinopyranoside, which exhibited strong cytotoxicity against A549 ...
Sumi A - - 2012
SUMMARY Rotavirus is a common viral cause of severe diarrhoea. For the underlying cause of rotavirus seasonality, the meteorological factor has been suspected, whereas quantitative correlation between seasonality and meteorological factor has not been fully investigated. In this study, we investigated the correlation of temporal patterns of the isolation rate ...
Czepa D - - 2012
Episodes of bleeding in people with haemophilia (PWH) are associated with reduced activity and limitations in physical performance. Within the scope of the 'Haemophilia & Exercise Project' (HEP) PWH were trained in a sports therapy programme. Aim of this study was to investigate subjective and objective physical performance in HEP-participants ...
Utter Jennifer - - 2012
Aim:  The study aims to describe the prevalence of weight loss behaviours and weight-related concerns among a nationally representative sample of adolescents in New Zealand. Methods:  Data for this study were collected as part of Youth'07, a nationally representative survey of the health and well-being of 9107 secondary school students ...
Rothschild C - - 2012
Immune tolerance induction (ITI) can eliminate factor VIII (FVIII) inhibitory antibodies that appear during FVIII replacement therapy. If first-line ITI fails, switching to a different FVIII concentrate, especially one containing von Willebrand factor (VWF), has been advocated. The objective of the study was to assess the efficacy and safety of ...
Chen Y-B - - 2012
Acute intestinal GVHD remains a major source of morbidity after allogeneic hematopoietic cell transplantation (HCT). α4β7 integrin is a cell surface molecule that mediates lymphocyte trafficking to intestinal tissue. In this analysis, peripheral blood was collected at the time of presentation of symptoms of acute GVHD and before any treatment. ...
Cao Jinxin - - 2012
Long aromatic polyamide chains are prepared from the corresponding monomers. The resultant polymer adopts a hollow helical conformation that is stabilized by intramolecular H-bonding interaction between side chains.
Páez Maria-Carolina - - 2012
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of antibodies. SLE has been associated with placental pathology, a finding that is also the determinant in preeclampsia (PE). Genetic evidence and serologic reports suggest laminin-1 (LM-111) as an immunogenic molecule and its polymorphic gene as a ...
Lukashev Pavel - - 2012
Electric field control of magnetization is one of the promising avenues for achieving high-density energy-efficient magnetic data storage. Ferroelectric materials can be especially useful for that purpose as a source of very large switchable electric fields when interfaced with a ferromagnet. Organic ferroelectrics, such as poly(vinylidene fluoride) (PVDF), have an ...
Reeksting Shaun B - - 2012
Malaria tropica is a devastating infectious disease caused by Plasmodium falciparum. This parasite synthesizes vitamin B6 de novo via the pyridoxal 5-phosphate (PLP) synthase enzymatic complex consisting of PfPdx1 and PfPdx2 proteins. Biosynthesis of PLP is largely performed by PfPdx1, ammonia provided by PfPdx2 subunits, is condensed together with d-ribose ...
Furmedge J - - 2012
To explore the experiences and educational needs of parents learning to use an Implanted Central Venous Access Device (IVAD) to administer clotting factor to their child with haemophilia. Parents of children with haemophilia who had learnt to administer clotting factor via IVAD attended focus groups to discuss their experiences of ...
Ware Tyson L - - 2012
Aim:  To audit clinical practice and assess early outcomes for infants with epileptic spasms after an agreed initial treatment protocol was adopted. Methods:  We reviewed all cases of epileptic spasms diagnosed between July 2007 and June 2009 and assessed adherence to protocol, remission by day 14, spasm recurrence and side ...
Chen Xiang-Feng - - 2012
In this paper, the potential applications of metal-organic framework (MOF) materials as fiber coatings for the solid-phase microextraction (SPME) of polycyclic aromatic hydrocarbons (PAHs) in water samples were explored. Fibers coated with MIL-53(Al, Cr, Fe) materials were fabricated by an adhesive method for SPME. The quantitation was performed by gas ...
Liu Zhicheng - - 2012
Various large-area 2D gold nanorod arrays are achieved on plasma-etched block copolymer templates. With the help of capillary forces, aqueous gold nanorods assembled on the templates show good position selectivity and high coverage of the grooves. Furthermore, these nanorod arrays can transform into gold nanowires by a post-etching process.
Aaslund Mona Kristin - - 2012
Rehabilitating walking in ambulatory patients post-stroke, with training that is safe, task-specific, intensive, and of sufficient duration, can be challenging. Some challenges can be met by using body-weight-supported treadmill training (BWSTT). However, it is not known to what degree walking characteristics are similar during BWSTT and overground walking. In addition, ...
Kim Seok - - 2012
A theoretical model is introduced to evaluate the ultimate resolution of plasmonic lithography using a ridge aperture. The calculated and experimental results of the line array pattern depth are compared for various half pitches. The theoretical analysis predicts that the resolution of plasmonic lithography strongly depends on the ridge gap, ...
Stöggl T - - 2012
To determine the relationship of muscle activation, force production, and cycle characteristics to O(2) extraction during high- and lower-intensity double poling (DP), nine well-trained male cross-country skiers performed DP on a treadmill for 3 min at 90% VO(2peak) followed by 6 min at 70%. During the final minute at each workload, arterial, ...
Choi Jin Ho - - 2012
A new fabrication method of a polydimethylsiloxane (PDMS) stencil embedded microwell plate is proposed and applied to a localized culture of Purkinje neurons (PNs) and neural stem cells (NSCs). A microwell plate combines a PDMS stencil and well plate. The PDMS stencil was fabricated by spin casting from an SU-8 ...
Saunders Russell William - - 2012
Marine aerosol is highly enriched in iodine, mostly in the form of iodate (IO3-) ions, compared to its relative abundance in seawater. This paper describes a laboratory study of the photochemical reduction of IO3- in the presence of humic acid. Spectroscopic analysis showed that ~ 20% of IO3- was converted ...
Yang Yong - - 2012
The flavanone hesperetin is known to decrease basal glucose uptake, although the inhibitory mechanism is largely unknown. Here, we used MDA-MB-231 breast cancer cells to investigate the molecular pathways affected by hesperetin. The results indicate that the suppression of glucose uptake is caused by the down-regulation of glucose transporter 1 ...
Paczosa-Bator Beata - - 2012
A platinum nanoparticles (PtNPs) layer is used for the first time as an ion-to-electron transducer in a solid-state ion-selective electrode (SC-ISE). The electrode was prepared by adding the PtNPs as an intermediate layer between the ionophore-doped solvent polymeric membrane and the electrical conductor. The PtNPs layer was characterized by high ...
Gandolfi M G - - 2012
AIM: To investigate nondestructively the percentage of 3D voids and marginal gaps in a pre-defined interface volume of interest (VOI) within root fillings produced by Thermafil Obturators with either a hydrophobic epoxy-resin-based sealer (AH Plus) or a hydrophilic flowable calcium-silicate sealer [mineral trioxide aggregate (MTA) Flow]. METHODOLOGY: Sixteen single root ...
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