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Torrecilla María - - 2012
Dysfunctional noradrenergic transmission is related to several neuropsychiatric conditions, such as depression. Nowadays, the role of G protein-coupled inwardly rectifying potassium (GIRK)2 subunit containing GIRK channels controlling neuronal intrinsic excitability in vitro is well known. The aim of this study was to investigate the impact of GIRK2 subunit mutation on ...
Choi Eun-Kyung - - 2012
Edge-selectively grafted graphite (EGG) with poly(ether-ketone) was prepared by the Friedel-Crafts acylation in a mild polyphosphoric acid (PPA)-phosphorous pentoxide (P(2)O(5)) mixture. The homogeneous reaction dope was coagulated in air moisture at different temperatures. The morphology of expanded EGG was changed from balls, balls/rods and rods with respect to coagulation temperatures ...
Isik Zerrin - - 2012
Determination of cell signalling behaviour is crucial for understanding the physiological response to a specific stimulus or drug treatment. Current approaches for large-scale data analysis do not effectively incorporate critical topological information provided by the signalling network. We herein describe a novel model- and data-driven hybrid approach, or signal transduction ...
Nicholson Judith - - 2012
MDM2 participates in protein synthesis, folding, and ubiquitin-mediated degradation and is therefore a proteostasis hub protein. The MDM2 interactome contains over 100 proteins, yet stratification of dominant MDM2-interacting proteins has not been achieved. 8-plex iTRAQ (nanoLC-MS/MS) of MCF7 cells treated with Nutlin-3 identified the most abundant protein changes over early ...
Bahri Raoudha - - 2012
Background: The genetic differentiation of Bahrain natives is unclear because of the absence of adequate genetic studies. Aim: Eight Alu insertion polymorphisms have been analysed in Bahrainis and southern Iranians to examine the origins of Bahrainis and to determine their genetic position among wider Middle East populations. Subjects and methods: ...
Rakauskas Rimantas - - 2012
Basics of DNA barcoding suppose the creation and operation of an extensive library based on reliably (including possibility for validation) identified specimens. Therefore, information concerning morphological identification of the individual samples used for DNA barcoding, for example, identification keys and descriptions used, must be clearly explained. In addition, the maximum ...
Shi Feng - - 2012
Teamwork: Through relay catalysis by a Ru(II) complex and a chiral phosphoric acid ((S)-BPA in the scheme) recently developed by Zhou's group, hydrogen gas can act as the terminal reductant in the catalytic asymmetric hydrogenation of heterocycles. This is a completely new concept in the area of asymmetric hydrogenation.
Lin Tao - - 2012
Six steroidal saponins and two pregnane glycosides were isolated from the BuOH subfraction of 70% EtOH extract of Smilax microphylla C.H.Wright, among them two were new compounds (1 and 7). Pregnane glycosides were firstly isolated from the genus Smilax (Smilacaceae). Structures of the new compounds were determined on the basis ...
Parkinson K N - - 2012
BACKGROUND: Mothers' responses to questionnaire items assessing their child's weight status typically do not correspond to conventional clinical classifications based on body mass index (BMI). From this observation health professionals infer that mothers do not recognize overweight in their child. But the questions used have generally confounded factual judgements with ...
Feng Ji-Feng - - 2012
Abstract Background. The risk factors for No. 12p and No. 12b lymph node (LN) metastases in advanced gastric cancer (GC) remain controversial. The aim of this study was to investigate the risk factors for No. 12p and No. 12b LN metastases in advanced GC. Methods. From January 1999 to December ...
Hasnani-Samnani Zohra - - 2012
Abstract Objective: To describe the presenting signs, diagnostic findings, and outcomes of 64 cases of non-immune hydrops fetalis (NIHF) cases seen in Women's Hospital, Qatar during the years 2003-2011. Method: A retrospective chart review of patients with signs suggesting of NIHF was done. A detailed scan was performed and karyotyping ...
Thomson Gill - - 2012
Aim In this paper, we report on how formative research was utilised to design a social marketing campaign commissioned by a Primary Care Trust within an area of high social deprivation in the North of England. BACKGROUND: Men represent the majority of perpetrators of domestic violence and there is increasing ...
Sun Maxine - - 2012
OBJECTIVES: To examine cancer-specific mortality in patients with nodal metastases relative to patients without nodal involvement at nephrectomy for non-metastatic renal cell carcinoma in a population-based cohort. METHODS: A total of 11 374 non-metastatic renal cell carcinoma patients who underwent a lymph node dissection at nephrectomy were identified using the Surveillance, ...
Mozaffari-Khosravi Hassan - - 2012
ABSTRACT Introduction: Menopause is one of the important causes of osteoporosis which results from estrogen deficiency. In addition, some clinical and experimental evidence indicates that there is an association between increasing pro-inflammatory cytokine activity and postmenopausal bone loss. The purpose of this study was to determine the effect of garlic ...
Marino Louis - - 2012
Conflicts of interest L Marino, MD: none Joseph H. Friedman, MD : Lectures: Teva, General Electric Consulting: United Biosource; Bubaloo, Halsted, Reitman LLC; EMD Serono; Genzyme; Teva; Acadia; Addex Pharm; UBC; Roche, Lundbeck Research: MJFox; NIH: EMD Serono; Teva; Acadia; Avid; Schering Plough Royalties: Demos Press.
Cruise Sharon - - 2012
Aim:  Chloral hydrate is generally considered a safe and effective single dosing procedural sedative for neonates in the clinical setting. However, its safety profile as a repetitive dosing maintenance sedative is largely unknown. This study aimed to document current administration practices of chloral hydrate in the Neonatal Unit, Royal Children's ...
Mitchell Meghan B - - 2012
Accurate measurement of cognitive function is critical for understanding the disease course of Alzheimer's disease (AD). Detecting cognitive change over time can be confounded by level of premorbid intellectual function or cognitive reserve and lead to under- or over-diagnosis of cognitive impairment and AD. Statistical models of cognitive performance that ...
Müller Thomas - - 2012
From analysis towards synthesis: Charged microdroplets act as microreaction vessels, extending the use of electrospray mass spectrometry from chemical analysis to synthesis. Application of this unique reaction conditions allows microscale carbon-carbon bond forming reactions to be performed rapidly and in high yields.
Johnsen Anna Thit - - 2012
OBJECTIVES: The aim of the study was to investigate the adequacy of help delivered by the healthcare system for 12 symptoms/problems in a national, randomly selected sample of advanced cancer patients in Denmark. METHODS: Advanced cancer patients (n = 1630) from 54 hospital departments across Denmark received the 3-Levels-of-Needs Questionnaire (3LNQ). The ...
Reyes-Esparza Jorge - - 2012
In the present study, we evaluated the effect of an analogue of L-carnitine on parameters involved with Metabolic Syndrome in obese Zucker rats. Twenty-four rats were treated for five weeks with L-carnitine (300 mg/kg) and its analogue at two concentrations (100 and 250 mg/kg) to assess their impact on glucose, ...
Cader Rizna A - - 2012
AIMS AND OBJECTIVES: To assess the degree of overhydration in our peritoneal dialysis patients and to examine the factors contributing to overhydration. BACKGROUND: Volume control is critical for the success of peritoneal dialysis, but dry weight has been difficult to ascertain accurately. Chronic fluid overload and hypertension are among the ...
Yang Mei-Ling - - 2012
Modifications of both DNA and protein by methylation are key factors in normal T and B cell immune responses as well as in the development of autoimmune disease. For example, the failure to maintain the methylation status of CpG dinucleotides in DNA triggers T cell autoreactivity. Methylated proteins are known ...
Arabin Birgit - - 2012
Abstract Aim of the study: Studies investigating the impact of pre- or postnatal music exposure on child development are scarce. Therefore we conducted this pilot study. Material and Methods: Five hundred pregnant women, 246 primigravidae and 254 multigravidae were interviewed about listening to, singing and performing music during pregnancy and ...
Humphries T J - - 2012
Pain is a critical aspect in the lives of individuals with congenital haemophilia A or B. Initially, pain serves as a warning sign for an active bleeding event; however, after multiple bleeding episodes, pain may become chronic, debilitating, and distracting. It is essential that pain instruments be developed and validated ...
Luo Shaobo - - 2012
The aim of this study was to investigate the impact of a Chinese herbal decoction on the intracellular calcium (Ca2+) concentration of sperm and the expression of the cation channel 1 of sperm (CatSper1), which is a calcium-channel protein specific to sperm tail, in a murine model of asthenospermia induced with ...
Roy Babhrubahan - - 2012
High fidelity chromosome segregation is essential for efficient transfer of the genetic material from the mother to daughter cells. The kinetochore, which connects the centromere DNA to the spindle apparatus, plays a pivotal role in this process. In spite of considerable divergence in the centromere DNA sequence, basic architecture of ...
Galdi A - - 2012
SrRuO(3) is a strong itinerant ferromagnet showing many features of 'bad metals' together with Fermi liquid behavior at very low temperature. The intriguing magnetic and transport properties of SrRuO(3) are tightly related to structure, as commonly observed in transition metal oxides. Here we report on the correlation of structural parameters ...
Liu An-Hua - - 2012
Steric bulk controls CO(2) absorption: N-substituted amino acid salts in poly(ethylene glycol) reversibly absorb CO(2) in nearly 1:1 stoichiometry. Carbamic acid is thought to be the absorbed form of CO(2) ; this was supported by NMR and in situ IR spectroscopy, and DFT calculations. The captured CO(2) could be converted ...
Guven Sirin - - 2012
Abstract Background: Volume guaranteed (VG) synchronized intermittent mandatory ventilation (SIMV) is a novel mode of SIMV that provides automatic adjustment of the peak inspiratory pressure for ensuring a minimum set tidal volume and there are limited data about the effects of VG ventilation on short term neonatal outcomes in preterm ...
Hauspie S - - 2012
The objective of this study is to describe the normal histological appearance of the dorsoproximal aspect of the sagittal ridge of the third metacarpal/metatarsal bone in young Warmblood horses, and to compare it to the different radiographic variations (irregular, indentation, lucency, notch) described at this level. A total of 25 ...
Carroll Michael P - - 2012
A method for the catalytic asymmetric α-arylation of ketones bearing very sterically hindered aryl rings has been developed. This reaction occurs under mild conditions, in short reaction times and has been applied to the first catalytic asymmetric synthesis of isoflavanones.
Hou Chenlu - - 2012
We integrate sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) with subsequent antibody probing in a single, monolithic microdevice to realize microfluidic Western blotting. A hurdle to successful on-chip Western blotting lies in restoring antibody recognition of previously sized (denatured, reduced) proteins. To surmount this hurdle, we locally dilute free SDS ...
Zhang Guoqi - - 2012
A cationic cobalt(II)-alkyl complex is an effective precatalyst for hydrogenation of alkenes, aldehydes, ketones, and imines under mild conditions (1-4 atm H(2) ; see scheme). The catalyst shows a high functional-group tolerance across a broad range of substrates. Experiments suggest that the active catalytic species is a cobalt(II)-hydride complex.
Shimada Mai - - 2012
Introduction The objective of this study was to determine the resource utilization of a tertiary care Japanese emergency department (ED) that was not immediately adjacent to the area of the 2011 Great East Japan earthquake and tsunami. METHODS: A retrospective chart review was performed at a tertiary care university-based urban ...
Mantelli D - - 2012
We evaluate the chemical potential of a one-dimensional quantum dot coupled to an atomic force microscope tip. The dot is described within the Luttinger liquid framework, and the conductance peak positions as a function of the tip location are calculated in the linear and non-linear transport regimes for an arbitrary ...
Callaerts-Vegh Z - - 2012
Lysophosphatidic acid (LPA) is a bioactive lipid acting on the nervous system through at least 6 different G protein-coupled receptors. In this study, we examined mice lacking the LPA(5) receptor using an extensive battery of behavioral tests. LPA(5) -deficient mice showed decreased pain sensitivity in tail withdrawal, faster recovery in ...
Bubonja-Sonje Marina - - 2012
Abstract Background: Listeria monocytogenes usually causes mild maternal illness, but can be devastating to the fetus. Case: Listeriosis in a pregnant patient successfully treated with empiric antibiotic therapy is described. After induced delivery, despite severe placental infection, a healthy infant was born. Additionally, archived placental specimens with similar pathological manifestation ...
Ochola Sophie A - - 2012
OBJECTIVE: To determine the impact of facility-based semi-intensive and home-based intensive counselling in improving exclusive breast-feeding (EBF) in a low-resource urban setting in Kenya. DESIGN: A cluster randomized controlled trial in which nine villages were assigned on a 1:1:1 ratio, by computer, to two intervention groups and a control group. ...
Wu Jilong - - 2012
Cell-mediated autoimmunity has been suggested to be involved in the melanocyte apoptosis that occurs in vitiligo. We investigated the cytotoxicity to autologous melanocytes of CD8+ T cells from the perilesional margins and peripheral blood samples of vitiligo patients. CD8+ T cells isolated from skin biopsied from the edges of depigmented skin patches ...
Holopainen Gunilla - - 2012
Encounters in relation to the nurse-patient relationship are often discussed within nursing and caring literature without a reflection on the actual meaning of the concept. Assuming that an encounter is essential for nursing care, this article seeks to create a deeper understanding of the concept through a hermeneutic approach to ...
Macconnell Grace - - 2012
Aims and objectives.  To describe the experiences of nurses who provided bereavement follow-up with families after the death of a child or a pregnancy loss and explore facilitators, barriers and challenges. Background.  Bereavement follow-up after the death of a child has been identified as an indicator of quality end of ...
Llorenç Víctor - - 2012
Purpose:  To evaluate clinical and paraclinical parameters for the indirect diagnosis of tuberculosis-related uveitis (TRU). Methods:  Prospective 2-year study in a tertiary referral centre. Patients with clinically suspected TRU were recruited. Demographical and clinical data were recorded. QuantiFERON(®) -TB Gold (QFT), tuberculosis skin test (TST) and pulmonary X-ray were performed, ...
Kogo Hiroshi - - 2012
Meiotic chromosome segregation requires homologous pairing, synapsis and crossover recombination during meiotic prophase. The checkpoint kinase ATR has been proposed to be involved in the quality surveillance of these processes, although the underlying mechanisms remain largely unknown. In our present study, we generated mice lacking HORMAD2, a protein that localizes ...
Tsai Yu-Chang - - 2012
Plants encounter environmental stress challenges distinct from those of other eukaryotes because of their relative non-mobility. Therefore, plants may have evolved distinct regulatory aspects of conserved cellular functions. Plants, like other eukaryotes, share aspects of both calcium and calmodulin-based cellular signaling and the autophagic process of cellular renewal. Here, we ...
Gao Guo-Yi - - 2012
ABSTRACT Gender may be related with the outcome of patients with acute traumatic brain injury. We explored the effect of gender on the outcome of 7145 patients with acute traumatic brain injury. There was no statistical difference between male and female in the causes of trauma, age, GCS score, CT ...
Danzl Megan M - - 2012
Connecting the continuum of post-acute care stroke services may be important for easing patients' transition between settings and facilitating recovery and community reintegration. The use of outcome measures is suggested as one means of connecting the continuum. The purpose of this qualitative case study is to describe administrators' and physiotherapists' ...
Shetty Vinutha B - - 2012
Aim:  To evaluate the incidence, sex distribution, ethnicity, age at diagnosis, clinical presentation and morbidity of all childhood-onset congenital adrenal hyperplasia (CAH) cases in Western Australia (WA) between 1990 and 2010, a state where newborn screening for CAH is not in place. Methods:  The total number of all known CAH ...
Durand Caylib A - - 2012
During the progression of autoimmune (type 1) diabetes, T cells and macrophages infiltrate the pancreas, disrupt islet function, and destroy insulin-producing beta cells. B-lymphocytes, particularly innate like B-cell populations such as marginal zone B cells and B-1 cells, have been implicated in many autoimmune diseases, and non-obese diabetic (NOD) mice ...
Akhtar Hashaam - - 2012
ABSTRACT: BACKGROUND: Transgender males are at high risk for sexually transmitted diseases including AIDS caused by the notorious Human Immunodeficiency Virus (HIV), yet little consideration is given by the policy makers, researchers and non-governmental organizations (NGOs) towards this sensitive issue in Pakistan. METHODS: In this study, we have investigated the ...
Zhou Wei - - 2012
High-pressure synchrotron x-ray powder diffraction experiments were performed on PbVO(3) tetragonal perovskite in a diamond anvil cell under hydrostatic pressures of up to 10.6 GPa at room temperature. The compression behavior of the PbVO(3) tetragonal phase is highly anisotropic, with the c-axis being the soft direction. A reversible tetragonal to cubic ...
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