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Rosenbaum Susann - - 2012
ABSTRACT: BACKGROUND: It has recently been shown that the lactation-induced inflammatory state in the liver of dairy cows is accompanied by activation of the nuclear factor E2-related factor 2 (Nrf2) pathway, which regulates the expression of antioxidant and cytoprotective genes and thereby protects tissues from inflammatory mediators and reactive oxygen ...
Hodroge A - - 2012
Background: The VKORC1 gene codes for the VKORC1 enzyme which is responsible for the reduction of vitamin K epoxide into vitamin K. VKORC1 enzyme is the target of vitamin K antagonists (VKA). Twenty-eight rare single mutations in the VKORC1 coding sequence have been reported from resistant patients receiving unusually high ...
Aldea Sorin - - 2012
Background Endoscopic endonasal optic nerve decompression (EEOND) is indicated in traumatic and endocrine orbitopathies as well as in idiopathic intracranial hypertension.Case We present a patient with bilateral nonspecific inflammatory orbitopathy (NSIO) and optic nerve compression presenting with acute severe visual loss. Bilateral orbital and optic nerve decompression was performed as an emergency ...
Frick Stefanie U - - 2012
Nanoparticles (NP) represent a promising tool for biomedical applications. Here, sulfonate- and phosphonate-functionalized polystyrene NP are analyzed for their interaction with human monocyte-derived dendritic cells (DC). Immature dendritic cells (iDC) display a higher time- and dose-dependent uptake of functionalized polystyrene NP compared to mature dendritic cells (mDC). Notably, NP induce ...
Tomazoni Shaiane Silva - - 2012
HMG-CoA reductase inhibitors are the most frequently prescribed drugs for treatment of lipid imbalance, but they have side effects, such as myopathy. Our aim was to assess the effect of simvastatin on the inflammatory process induced by skeletal muscle injury. Rats were divided into experimental groups [control group, simvastatin (20 ...
Lardy Julien - - 2012
Arm movements when rotating a spherical object were experimentally investigated. Twelve volunteers participated in the experiment and were asked to rotate a sphere for a large range of amplitude. Results showed that subjects anticipated their posture at the beginning of object manipulation even for low rotation amplitudes. The way of ...
Hari Durga Prasad - - 2012
The photocatalytic reaction of o-methylthio-arenediazonium salts with alkynes yields substituted benzothiophenes regioselectively through a radical annulation process. Green light irradiation of eosin Y initiates the photoredox catalysis. The scope of the reaction was investigated by using various substituted diazonium salts and different alkynes.
Fuchs Barbara - - 2012
Allergic asthma is a chronic inflammatory disease, characterized by airway hyperresponsiveness (AHR), inflammation and tissue remodelling, in which mast cells play a central role. In the present study, we analyzed how mast cell numbers and localization influence the AHR in a chronic murine model of asthma. C57BL/6 (wild-type) and mast ...
Booth A R - - 2012
BACKGROUND: This study uses the theory of planned behaviour (TPB) as a framework to investigate salient beliefs about chlamydia testing, amongst young people living in relatively deprived areas. These beliefs may form targets for intervention to increase testing in this high-risk population. METHODS: Participants recruited from colleges in deprived areas ...
Sallam Salem A - - 2012
Abstract Background: Breastfeeding within the first hour of life is a potential mechanism for health promotion and is considered to be an indicator of excellence of breastfeeding. This study was conducted to evaluate the knowledge, attitude, and practice regarding early breastfeeding initiation within the first hour of life in both ...
Oh Jin-Kyoung - - 2012
ABSTRACT: BACKGROUND: There has been limited study on the effect of infection with different hepatitis C virus (HCV) genotypes on the risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) endemic regions of Asia. METHODS: Hazard ratios of HCC development were estimated for HBV and HCV co-infected subjects among ...
Yi Ping - - 2012
The molecular mechanisms and cellular targets of Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma (HCC), remain to be fully characterized. Recent studies have shown that Sorafenib induces tumor cell death through the activation of endoplasmic reticulum (ER) stress signaling and/or autophagy in various cellular models. Using ...
van Zuuren E J - - 2012
Female pattern hair loss (FPHL) or androgenic alopecia is the most common type of hair loss affecting women with reduced hair density and can have a serious psychological impact. It is characterized by progressive replacement of slow cycling terminal hair follicles by miniaturized, rapidly cycling vellus hair follicles. The frontal ...
Ak Hawkins - - 2012
Predictive testing (PT) for Huntington disease (HD) usually requires several in-person appointments; which acts as a barrier to testing for those from remote regions. This pilot study reports the use of telehealth PT to examine whether such testing improves access to HD PT while maintaining quality of care and support. ...
Mager Diana R - - 2012
Background: Nonalcoholic fatty liver disease (NAFLD) is increasing at alarming rates in obese children. The study aim was to describe body composition/somatotype and its interrelationships to biomarkers of liver disease, insulin resistance, and lipid and cytokine expression in youth with NAFLD. Methods: Somatotype and body composition of children (7-18 years) ...
Shimizu Azusa - - 2012
An otherwise healthy, developmentally normal 3-week-old male infant presented with complex multisuture craniosynostosis involving the metopic suture and bilateral coronal sutures with frontal prominence and hypotelorism. Frontal craniectomy and bilateral frontoorbital advancement remodeling were performed at the age of 5 months. The postoperative course was uneventful. The child's development was ...
Bordeaux John Michael - - 2012
Sirex noctilio F., a Eurasian horntail woodwasp recently introduced into North America, oviposits in pines and other conifers and in the process spreads a phytopathogenic fungus that serves as a food source for its larvae. During oviposition the woodwasp also deposits mucus produced in its acid (venom) gland that alters ...
Guégan Jean-Philippe - - 2012
Hepatocellular carcinoma treatment by arterial infusion of cisplatin exhibits certain therapeutic efficacy. However, optimizations are required and the mechanisms underlying cisplatin pro-apoptotic effect remain unclear. The mitogen-activated protein kinase (MAPK) pathway plays a key role in cell response to cisplatin and the functional specificity of the isoform MEK1/2 and ERK1/2 ...
Kwong Waldan K - - 2012
The gut-associated bacteria Snodgrassella alvi and Gilliamella apicola from the honeybee Apis mellifera and bumblebees, Bombus, spp., were isolated in axenic culture. Two strains from A. mellifera were characterized and proposed as type strains: Snodgrassella alvi wkB2(T) gen. nov., sp. nov. (wkB2(T) = NCIMB 14803(T) = NRRL B-59751(T)) and Gilliamella ...
Waterham Hans R - - 2012
Smith-Lemli-Opitz syndrome (SLOS; OMIM #270400) is an autosomal recessive malformation syndrome characterized by a large spectrum of morphogenic and congenital anomalies. SLOS is caused by mutations in the DHCR7 gene, which encodes 7-dehydrocholesterol reductase, the enzyme that catalyzes the final step in cholesterol biosynthesis. We report on 154 currently known ...
Elliott Robert E - - 2012
Object Some centers report a lower incidence of vertebral artery (VA) injury with C-2 pars screws compared with pedicle screws without sacrificing construct stability, despite biomechanical studies suggesting greater load failures with C-2 pedicle screws. The authors reviewed published series describing C-2 pars and pedicle screw implantation and atlantoaxial fusions ...
Janjigian Yelena Y - - 2012
Gastric cancer is among the most common human malignancies and the second leading cause of cancer-related death. The different epidemiologic and histopathology of subtypes of gastric cancer are associated with different genomic patterns. Data suggests that gene expression patterns of proximal, distal gastric cancers-intestinal type, and diffuse/signet cell are well ...
Valtonen Maarit K - - 2012
Aim: Abundant evidence suggests that depression is a risk factor for cardiovascular disease and metabolic syndrome. Systemic low-grade inflammation and evolving abdominal obesity are hypothesised to be underlying mechanisms explaining the relationship. To test this hypothesis we examined the association of depressive symptoms and inflammation in developing abdominal obesity. Methods: ...
Lee Pei-Wen - - 2012
Background: Polycystic kidney disease (PCKD) is one of the most common inherited disorders in end-stage renal disease patients. It is generally thought that the survival of PCKD patients undergoing dialysis surpasses that of general dialysis patients, but the cause of this improved survival is not clear. Methods: Using Taiwan's national ...
Karow Marisa - - 2012
Reprogramming of somatic cells into neurons provides a new approach toward cell-based therapy of neurodegenerative diseases. A major challenge for the translation of neuronal reprogramming into therapy is whether the adult human brain contains cell populations amenable to direct somatic cell conversion. Here we show that cells from the adult ...
Meyer L - - 2012
Stars with short orbital periods at the center of our Galaxy offer a powerful probe of a supermassive black hole. Over the past 17 years, the W. M. Keck Observatory has been used to image the galactic center at the highest angular resolution possible today. By adding to this data ...
Walsh Bronagh - - 2012
OBJECTIVES: To describe outcomes after unplanned hospital admission in older people and to determine whether disease trajectories in those admitted with ill-defined conditions (symptoms and signs) are distinct from other diagnostic groups and consistent with known disease trajectories. DESIGN: Longitudinal follow-up after a retrospective cross-sectional study of emergency admissions to ...
Creighton Sarah M - - 2012
The diagnosis and early management of genitourinary disorders in children is challenging for the child, parents and carers. There have been enormous developments in paediatric care medically and surgically and as a result many patients with complex anomalies reach adult life and have a normal desire for a good quality ...
Yoo Woo-Jin - - 2012
Lights, camera, action! An efficient protocol for the formation of methylene-bridged bis-1,3-dicarbonyl compounds has been developed through an aerobic photocatalytic oxidative coupling reaction between 1,3-dicarbonyl compounds and a tertiary aliphatic amine.
Zhao Xinghui - - 2012
Chronic hepatitis B virus (HBV) infection is an independent risk factor for the development of hepatocellular carcinoma (HCC). The HBV HBx gene is frequently identified as an integrant in the chromosomal DNA of patients with HCC. HBx encodes the X protein (HBx), a putative viral oncoprotein that affects transcriptional regulation ...
While Peter T - - 2012
Ohmic heating is a serious problem in gradient coil operation. A method is presented for redesigning cylindrical gradient coils to operate at minimum peak temperature, while maintaining field homogeneity and coil performance. To generate these minimaxT coil windings, an existing analytic method for simulating the spatial temperature distribution of single ...
Addou Ammara Nariman - - 2012
A novel filamentous bacterium designated Nari11AT was isolated from soil collected from a salt lake named Chott Melghir located in south east of Algeria. The strain is an aerobic, halophilic, thermotolerant, Gram-positive bacterium, growing at NaCl concentrations between 5 and 20% w/v and temperature and pH ranges between 43-60 °C ...
Ali Ahmad - - 2012
BACKGROUND: Hypertension has a multifactorial background based on genetic and environmental interactive factors. OBJECTIVES: We aimed to test for the association of the angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) gene polymorphisms with hypertension.Subjects and methods:Participants included 120 Saudi patients with hypertension and 250 normal healthy controls. For ...
Zhang Qifeng - - 2012
Light scattering is a method that has been employed in dye-sensitized solar cells for optical absorption enhancement. In conventional dye-sensitized solar cells, large TiO(2) particles with sizes comparable to the wavelength of visible light are used as scatterers by either being mixed into the nanocrystalline film to generate light scattering ...
Hester Sydney M - - 2012
Object Intrathecal baclofen therapy has been used successfully for intractable spasticity in children with cerebral palsy. Infections are rare, but they are potentially life threatening if complicated by bacteremia or meningitis. Treatment without removal of the system is desirable if it can be done safely and effectively. Methods The authors ...
Hossain Md Delwar - - 2012
Stepwise complexation: A green copper-based metallo-supramolecular polymer was successfully synthesized through complexation of Cu(II) ions with new bis(1,10-phenanthroline) ligands. The obtained polymer showed an excellent electrochromic color change from green to colorless upon electrochemical reduction of Cu(II) to Cu(I) .
Frieauff W - - 2012
The in vitro micronucleus test (MNT) is a well-established test for early screening of new chemical entities in industrial toxicology. For assessing the clastogenic or aneugenic potential of a test compound, micronucleus induction in cells has been shown repeatedly to be a sensitive and a specific parameter. Various automated systems ...
Zheng Wen Tao - - 2012
In a study on the diversity of rhizobia isolated from root nodules of Astragalus sinicus, five strains showed identical nucleotide sequences of 16S rRNA gene. They were most related to the type strains of Mesorhizobium loti, M. shangrilense, M. ciceri and M. australicum, with sequence similarities of 99.6 % to ...
Endo Hidenori - - 2012
Object Internal coil trapping is a treatment method used to prevent rebleeding from a ruptured intracranial vertebral artery dissection (VAD). Postoperative medullary infarctions have been reported as a complication of this treatment strategy. The aim of this study was to determine the relationship between a postoperative medullary infarction and the ...
Mesía R - - 2012
BackgroundCetuximab combined with radiotherapy (RT) is a treatment option for head and neck cancer. The objectives of this randomized, phase II trial were to evaluate the efficacy and safety of cetuximab maintenance therapy following definitive RT with concomitant cetuximab in patients with oropharyngeal cancer.Patients and methodsNinety-one patients with stage III-IV ...
Matson Benjamin D - - 2012
Fe(iii)-meso-tetra(pyridyl)porphyrins are electrocatalysts for the reduction of dioxygen in aqueous acidic solution. The 2-pyridyl derivatives, both the triflate and chloride salts, are more selective for the desired 4e(-) reduction than the isomeric 4-pyridyl complexes. The inward-pointing pyridinium groups influence proton delivery despite their distance from the iron centre.
Zhu Yan - - 2012
Flux balance analysis (FBA) has been widely used in calculating steady-state flux distributions that provide important information for metabolic engineering. Several thermodynamics-based methods, e.g. quantitative assignment of reaction directionality and energy balance analysis have been developed to improve the prediction accuracy of FBA. However, these methods can only generate a ...
Agnew Rona - - 2012
BACKGROUND: A major challenge for determining the effectiveness of community-based continence promotion campaigns is recruitment of a representative sample of incontinent participants who have not previously sought care. PURPOSE: To evaluate the efficiency of engaging community organisations as catalysts for recruitment of community-dwelling older women with incontinence to the 'Continence ...
Halton Jacqueline M - - 2012
BACKGROUND: A Human Resources (HR) Committee of C17, the national network of Canadian academic pediatric hematology/oncology programs, obtained comprehensive data enabling analysis and planning for the physician workforce. This study establishes physician to patient ratios and predicts workforce needs for Canadian pediatric hematology/oncology programs. PROCEDURES: Over a 10-year period, six ...
Abdallah M W - - 2012
OBJECTIVE: To examine levels of 3 neurotrophic factors (NTFs): Brain derived neurotrophic factor (BDNF), Neurotrophin-4 (NT-4), and transforming growth factor-β (TGF-β) in dried blood spot samples of neonates diagnosed with autism spectrum disorders (ASD) later in life and frequency-matched controls. METHOD: Biologic samples were retrieved from the Danish Newborn Screening ...
Baldari C - - 2012
The Cosmed AquaTrainer® snorkel, in connection with the K4b2 analyzer, is the most recent instrument used for real time gas analysis during swimming. This study aimed to test if a new AquaTrainer® snorkel with 2 (SV2) or 4 (SV4) valves is comparable to a standard face mask (Mask) being valid ...
Mida Kfir - - 2012
The aim was to determine the relative role of each of the lactogenic hormones (insulin, prolactin and hydrocortisol), and their combinations in regulating elongation and desaturation of polyunsaturated fatty acids and subsequently on composition of cellular lipid compartments in mammary epithelia. Cultured cells of the mammary gland epithelial cell line ...
Lehr Hans-Anton - - 2012
Several authors have demonstrated an increased number of mitotic figures in breast cancer resection specimen when compared with biopsy material. This has been ascribed to a sampling artifact where biopsies are (i) either too small to allow formal mitotic figure counting or (ii) not necessarily taken form the proliferating tumor ...
Suarez-Jimenez Benjamin - - 2012
In humans, temperament plays an important role in socialization and personality. Some temperaments, such as behavioral inhibition are associated with an increased risk for psychopathology. Nonhuman primates can serve as a model for neurobiological and developmental contributions to emotional development and several recent studies have begun to investigate temperament in ...
Xiao Yanhong - - 2012
On the basis of microarray analyses of the salt-tolerant wheat mutant RH8706-49, a previously unreported salt-induced gene, designated as TaHPS [Triticum aestivum hypothetical (HPS)-like protein], was cloned. Real-time quantitative PCR analyses showed that expression of the gene was induced by abscisic acid, salt and drought. The encoded protein was found ...
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