Search Results
Results 751 - 800 of 3450
< 11 12 13 14 15 16 17 18 19 20 21 >
Hodroge A - - 2012
Background: The VKORC1 gene codes for the VKORC1 enzyme which is responsible for the reduction of vitamin K epoxide into vitamin K. VKORC1 enzyme is the target of vitamin K antagonists (VKA). Twenty-eight rare single mutations in the VKORC1 coding sequence have been reported from resistant patients receiving unusually high ...
Eggert Stacey L SL Department of Genetics, Harvard Medical School, Boston, MA 02115, - - 2012
Uterine leiomyomata (UL), the most prevalent pelvic tumors in women of reproductive age, pose a major public health problem given their high frequency, associated morbidities, and most common indication for hysterectomies. A genetic component to UL predisposition is supported by analyses of ethnic predisposition, twin studies, and familial aggregation. A ...
Karow Marisa - - 2012
Reprogramming of somatic cells into neurons provides a new approach toward cell-based therapy of neurodegenerative diseases. A major challenge for the translation of neuronal reprogramming into therapy is whether the adult human brain contains cell populations amenable to direct somatic cell conversion. Here we show that cells from the adult ...
Meyer L - - 2012
Stars with short orbital periods at the center of our Galaxy offer a powerful probe of a supermassive black hole. Over the past 17 years, the W. M. Keck Observatory has been used to image the galactic center at the highest angular resolution possible today. By adding to this data ...
Walsh Bronagh - - 2012
OBJECTIVES: To describe outcomes after unplanned hospital admission in older people and to determine whether disease trajectories in those admitted with ill-defined conditions (symptoms and signs) are distinct from other diagnostic groups and consistent with known disease trajectories. DESIGN: Longitudinal follow-up after a retrospective cross-sectional study of emergency admissions to ...
Creighton Sarah M - - 2012
The diagnosis and early management of genitourinary disorders in children is challenging for the child, parents and carers. There have been enormous developments in paediatric care medically and surgically and as a result many patients with complex anomalies reach adult life and have a normal desire for a good quality ...
Yoo Woo-Jin - - 2012
Lights, camera, action! An efficient protocol for the formation of methylene-bridged bis-1,3-dicarbonyl compounds has been developed through an aerobic photocatalytic oxidative coupling reaction between 1,3-dicarbonyl compounds and a tertiary aliphatic amine.
Zhao Xinghui - - 2012
Chronic hepatitis B virus (HBV) infection is an independent risk factor for the development of hepatocellular carcinoma (HCC). The HBV HBx gene is frequently identified as an integrant in the chromosomal DNA of patients with HCC. HBx encodes the X protein (HBx), a putative viral oncoprotein that affects transcriptional regulation ...
While Peter T - - 2012
Ohmic heating is a serious problem in gradient coil operation. A method is presented for redesigning cylindrical gradient coils to operate at minimum peak temperature, while maintaining field homogeneity and coil performance. To generate these minimaxT coil windings, an existing analytic method for simulating the spatial temperature distribution of single ...
Houzet Laurent - - 2012
MicroRNAs (miRNAs) are 22-nt non-coding RNAs involved in the regulation of cellular gene expression and potential cellular defense against viral infection. Using in silico analyses, we predicted target sites for 22 human miRNAs in the HIV genome. Transfection experiments using synthetic miRNAs showed that five of these miRNAs capably decreased ...
Addou Ammara Nariman - - 2012
A novel filamentous bacterium designated Nari11AT was isolated from soil collected from a salt lake named Chott Melghir located in south east of Algeria. The strain is an aerobic, halophilic, thermotolerant, Gram-positive bacterium, growing at NaCl concentrations between 5 and 20% w/v and temperature and pH ranges between 43-60 °C ...
Bloch Orin O Department of Neurological Surgery, University of California, San Francisco, California 94143-0112, - - 2012
Extent of resection (EOR) has been shown to be an important prognostic factor for survival in patients undergoing initial resection of glioblastoma (GBM), but the significance of EOR at repeat craniotomy for recurrence remains unclear. In this study the authors investigate the impact of EOR at initial and repeat resection ...
Ali Ahmad - - 2012
BACKGROUND: Hypertension has a multifactorial background based on genetic and environmental interactive factors. OBJECTIVES: We aimed to test for the association of the angiotensin-converting enzyme (ACE) and endothelial nitric oxide synthase (eNOS) gene polymorphisms with hypertension.Subjects and methods:Participants included 120 Saudi patients with hypertension and 250 normal healthy controls. For ...
Zhang Qifeng - - 2012
Light scattering is a method that has been employed in dye-sensitized solar cells for optical absorption enhancement. In conventional dye-sensitized solar cells, large TiO(2) particles with sizes comparable to the wavelength of visible light are used as scatterers by either being mixed into the nanocrystalline film to generate light scattering ...
Hester Sydney M - - 2012
Object Intrathecal baclofen therapy has been used successfully for intractable spasticity in children with cerebral palsy. Infections are rare, but they are potentially life threatening if complicated by bacteremia or meningitis. Treatment without removal of the system is desirable if it can be done safely and effectively. Methods The authors ...
Maeda Tomoya - - 2012
We previously reported that the Corynebacterium glutamicum RNase E/G encoded by the rneG gene (NCgl2281) is required for the 5' maturation of 5S rRNA. In the search for the intracellular target RNAs of RNase E/G other than the 5S rRNA precursor, we detected that the amount of isocitrate lyase, an ...
Kanatsu-Shinohara Mito - - 2012
Spermatogonial stem cells (SSCs) reside in specific niches within seminiferous tubules. These niches are thought to secrete chemotactic factors for SSCs, because SSCs migrate to them upon transplantation. However, the identity of these chemotactic molecules remains unknown. Here, we established a testis feeder cell culture system and used it to ...
Chow Eric J EJ Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA. - - 2013
Children treated for acute lymphoblastic leukemia (ALL) are more likely to become overweight. Prolonged exposure to high-dose glucocorticoids may cause insulin resistance and facilitate development of this phenotype. Body mass indices (BMI) and insulin resistance (homeostatic model assessment [HOMA]-IR) were prospectively measured among on- (n = 31) and off-therapy participants ...
Gil Jung-Eun JE Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of - - 2012
Protrudin is a FYVE (Fab 1, YOTB, Vac 1, and EEA1) domain-containing protein involved in transport of neuronal cargoes and implicated in the onset of hereditary spastic paraplegia. Our image-based screening of the lipid binding domain library revealed novel plasma membrane localization of the FYVE domain of protrudin unlike canonical ...
Sulej Agata A - - 2012
Ribonucleases (RNases) are valuable tools applied in the analysis of RNA sequence, structure and function. Their substrate specificity is limited to recognition of single bases or distinct secondary structures in the substrate. Currently, there are no RNases available for purely sequence-dependent fragmentation of RNA. Here, we report the development of ...
Otsuka Shigeto - - 2012
The taxonomic properties of strain DC2a-G7T, a Gram-negative, ovoid to rod, gellan gum-lysing bacterium, were examined. The 16S rRNA gene sequence similarity showed that strain DC2a-G7T is a member of the phylum Verrucomicrobia and the closest type strain of the described species is Verrucomicrobium spinosum DSM 4136T with a sequence ...
Hewett Timothy E - - 2013
Ligament reconstruction is the current standard of care for active patients with an anterior cruciate ligament (ACL) rupture. Although the majority of ACL reconstruction (ACLR) surgeries successfully restore the mechanical stability of the injured knee, postsurgical outcomes remain widely varied. Less than half of athletes who undergo ACLR return to ...
Sung Kyunghyun K Department of Radiology, Stanford University, Stanford, California, USA. - - 2013
Iterative thresholding methods have been extensively studied as faster alternatives to convex optimization methods for solving large-sized problems in compressed sensing. A novel iterative thresholding method called LCAMP (Location Constrained Approximate Message Passing) is presented for reducing computational complexity and improving reconstruction accuracy when a nonzero location (or sparse support) ...
Ding Yanpeng Y Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, - - 2012
Staphylococcus aureus readily infects humans, causing infections from mild superficial skin infections to lethal bacteremia and endocarditis. Transporters produced by S. aureus allow the pathogen to adapt to a variety of settings, including survival at sites of infection and in the presence of antibiotics. The native functions of many transporters ...
Martin W J J M - - 2012
Orofacial pain is a common complaint with multiple diagnoses. There is controversy about the effectiveness of antidepressants for the management of orofacial pain disorders. In order to be able to make a best evidence choice between available antidepressants for the treatment of orofacial pain, a systematic review was conducted of ...
Mai Wilson X - - 2012
Efficient and safe drug delivery has always been a challenge in medicine. The use of nanotechnology, such as the development of nano drug delivery systems (DDS), has received great attention with high enthusiasm owing to the potential that nanocarriers can theoretically act as "magic bullets" and selectively target affected organs ...
Okubo Sumiko - - 2012
Gemcitabine was approved for the treatment of biliary tract cancer in 2006 in Japan. While biliary tract cancer is usually associated with patients 70 years of age or older and/or those who tend to have underlying liver dysfunction, data on this population were limited in the Japanese Phase II study ...
Bishop Justin A JA Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA. - - 2013
Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland neoplasm that is defined by ETV6-NTRK3 gene fusion. To the best of the authors' knowledge, only rare case reports of the cytopathologic features of MASC have been published to date. A wide variety of archival salivary gland tumors were ...
Schwartz Richard H - - 2012
Inhaled corticosteroids (ICS) are drugs of choice for persistent asthma. Less than 500 µg/d of fluticasone are believed to be safe. We found 92 cases of adrenal suppression in PubMed; among these cases there were 13 children who took 500 µg/d or less of fluticasone. Adrenal insufficiency was diagnosed in ...
Di Giminiani P - - 2012
BACKGROUND: Porcine skin exhibits a high degree of homology to human skin, and the pig has recently been used as a cutaneous pain model. However, before the full potential of this novel in vivo cutaneous pain model can be achieved, several methodological aspects related to the management of awake animal ...
Steinberg Simon - - 2012
The structures of two new cubic {TnLa(3)}Br(3) (Tn = Ru, Ir; I4(1)32, Z = 8; Tn = Ru: a = 12.1247(16) Å, V = 1782.4(4) Å(3); Tn = Ir: a = 12.1738(19) Å, V = 1804.2(5) Å(3)) compounds belonging to a family of reduced rare-earth metal halides were determined by ...
Nyberg Colleen H - - 2012
OBJECTIVE: Although psychosocial stress has also been implicated as a contributor to growth failure by imposing energetic constraints during development, the direct physiological pathways by which these life history trade-offs are imposed are not well understood. This study explores associations between diurnal cortisol rhythms and differential patterns of linear child ...
Sikdar Rakesh - - 2013
We have reported that simultaneous deletion of two Escherichia coli genes, yqjA and yghB, encoding related and conserved inner membrane proteins belonging to the DedA protein family results in a number of intriguing phenotypes, including temperature sensitivity at 42°C, altered membrane lipid composition, and cell division defects. We sought to ...
André T - - 2012
BackgroundThe purpose of this study was to evaluate the combination of panitumumab and irinotecan in patients with KRAS wild-type metastatic colorectal cancer refractory to standard chemotherapy (oxaliplatin, fluoropyrimidines-irinotecan and bevacizumab).Patients and methodsKRAS status was first determined locally but subsequent validation of KRAS status and additional screenings (rare KRAS, NRAS, BRAF ...
Stritt Andrea - - 2012
This case describes evidence for a Shiga-toxin producing Escherichia coli (STEC) O146:H28 infection leading to hemolytic uremic syndrome in a neonate. STEC O146:H28 was linked hitherto with asymptomatic carriage in humans. Based on strain characteristics and genotyping data, the mother is a healthy carrier, who transmitted the STEC during delivery. ...
Cottrell Nicholas D - - 2012
Electrically based vehicles have produced some concern over their lack of sound, but the impact of artificial sounds now being implemented have not been examined in respect to their effects upon the driver. The impact of two different implementations of vehicle sound on driver stress in electric vehicles was examined. ...
Hedlund Kd - - 2012
Heparin is one of the oldest drugs still in widespread clinical use. Its discovery in 1916 predates the establishment of the Food and Drug Administration. Since 1935, over 15,000 research papers have been published on the effects of heparin. Because the exact chemical formula of heparin is unknown, synthetic manufacturing ...
Davydov Roman - - 2012
Cytochrome P450scc (CYP11A1) catalyzes conversion of cholesterol (CH) to pregnenolone, the precursor to all steroid hormones. This process proceeds via three sequential monooxygenation reactions: two stereospecific hydroxylations with formation first of 22R-hydroxycholesterol (22-HC) and then 20α,22R-dihydroxycholesterol (20,22-DHC), followed by C20-C22 bond cleavage. Herein we have employed EPR and ENDOR spectroscopy ...
Aldea Sorin - - 2012
Background Endoscopic endonasal optic nerve decompression (EEOND) is indicated in traumatic and endocrine orbitopathies as well as in idiopathic intracranial hypertension.Case We present a patient with bilateral nonspecific inflammatory orbitopathy (NSIO) and optic nerve compression presenting with acute severe visual loss. Bilateral orbital and optic nerve decompression was performed as an emergency ...
Frick Stefanie U - - 2012
Nanoparticles (NP) represent a promising tool for biomedical applications. Here, sulfonate- and phosphonate-functionalized polystyrene NP are analyzed for their interaction with human monocyte-derived dendritic cells (DC). Immature dendritic cells (iDC) display a higher time- and dose-dependent uptake of functionalized polystyrene NP compared to mature dendritic cells (mDC). Notably, NP induce ...
Bujor Andreea M AM Arthritis Center, Rheumatology, Boston University School of Medicine, Boston, MA 02118, USA. - - 2012
Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal organs. The present study was undertaken to examine the effects of ciprofloxacin, a fluoroquinolone antibiotic implicated in matrix remodeling, on dermal and lung fibroblasts obtained from SSc patients. Dermal and lung fibroblasts from SSc patients and healthy subjects ...
Tomazoni Shaiane Silva - - 2012
HMG-CoA reductase inhibitors are the most frequently prescribed drugs for treatment of lipid imbalance, but they have side effects, such as myopathy. Our aim was to assess the effect of simvastatin on the inflammatory process induced by skeletal muscle injury. Rats were divided into experimental groups [control group, simvastatin (20 ...
Lardy Julien - - 2012
Arm movements when rotating a spherical object were experimentally investigated. Twelve volunteers participated in the experiment and were asked to rotate a sphere for a large range of amplitude. Results showed that subjects anticipated their posture at the beginning of object manipulation even for low rotation amplitudes. The way of ...
Hari Durga Prasad - - 2012
The photocatalytic reaction of o-methylthio-arenediazonium salts with alkynes yields substituted benzothiophenes regioselectively through a radical annulation process. Green light irradiation of eosin Y initiates the photoredox catalysis. The scope of the reaction was investigated by using various substituted diazonium salts and different alkynes.
Fuchs Barbara - - 2012
Allergic asthma is a chronic inflammatory disease, characterized by airway hyperresponsiveness (AHR), inflammation and tissue remodelling, in which mast cells play a central role. In the present study, we analyzed how mast cell numbers and localization influence the AHR in a chronic murine model of asthma. C57BL/6 (wild-type) and mast ...
Svoboda Melissa D MD Oregon Health&Science University (OHSU), Portland, Oregon 97239, - - 2012
Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive genetic condition with a broad phenotype that results from deficiency of the final enzyme of the cholesterol synthesis pathway. This defect causes low or low-normal plasma cholesterol levels and increased 7- and 8-dehydrocholesterol (DHC) levels. Many therapies for SLOS and other disorders of ...
Booth A R - - 2012
BACKGROUND: This study uses the theory of planned behaviour (TPB) as a framework to investigate salient beliefs about chlamydia testing, amongst young people living in relatively deprived areas. These beliefs may form targets for intervention to increase testing in this high-risk population. METHODS: Participants recruited from colleges in deprived areas ...
Sallam Salem A - - 2012
Abstract Background: Breastfeeding within the first hour of life is a potential mechanism for health promotion and is considered to be an indicator of excellence of breastfeeding. This study was conducted to evaluate the knowledge, attitude, and practice regarding early breastfeeding initiation within the first hour of life in both ...
Oh Jin-Kyoung - - 2012
ABSTRACT: BACKGROUND: There has been limited study on the effect of infection with different hepatitis C virus (HCV) genotypes on the risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) endemic regions of Asia. METHODS: Hazard ratios of HCC development were estimated for HBV and HCV co-infected subjects among ...
Yi Ping - - 2012
The molecular mechanisms and cellular targets of Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma (HCC), remain to be fully characterized. Recent studies have shown that Sorafenib induces tumor cell death through the activation of endoplasmic reticulum (ER) stress signaling and/or autophagy in various cellular models. Using ...
< 11 12 13 14 15 16 17 18 19 20 21 >