Search Results
Results 701 - 750 of 3449
< 10 11 12 13 14 15 16 17 18 19 20 >
Allione Alessandra - - 2012
Inter-individual susceptibility to mutagens/carcinogens can be assessed by either genotyping DNA repair genes in different pathways or phenotyping DNA repair capacity (DRC) at the molecular or cellular level. Due to the large number of known DNA repair genes, and the interactions between repair pathways, phenotyping is becoming the preferred approach ...
Takahashi Hidetoshi - - 2012
We examined the relation between adalimumab and infliximab plasma trough levels, anti-adalimumab and anti-infliximab antibody formation. We analyzed plasma from 32 adalimumab-treated and 20 infliximab-treated psoriasis patients for evaluating trough levels of each drug. The presence of anti-adalimumab and anti-infliximab antibodies was analyzed and the severity of psoriasis was evaluated. ...
Ribeiro F - - 2012
This study aimed to examine the acute effects of cryotherapy on knee position sense and to determine the time period necessary to normalize joint position sense when exercising after cryotherapy. 12 subjects visited the laboratory twice, once for cryotherapy followed by 30 min of exercise on a cycloergometer and once for ...
Downward Alan M - - 2012
Heterodinuclear ruthenium(ii)-cobalt(iii) complexes have been prepared as part of investigations into a new approach to selective cancer treatment. A cobalt(iii) centre bearing amine ligands, which serve as models for cytotoxic nitrogen mustard ligands, is connected by a bridging ligand to a ruthenium(ii)-polypyridyl moiety. Upon excitation of the ruthenium centre by ...
Yang Xiao-Yan - - 2012
Conosilane A (1), a novel sesquiterpene with an unprecedented carbon skeleton, was isolated from the cultures of the basidiomycete Conocybe siliginea. Its structure was elucidated by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Conosilane A was found to inhibit 11β-hydroxysteroid dehydrogenase significantly.
Tüysüz Beyhan - - 2012
We present growth curves of 1,726 Turkish children with Down syndrome (DS) between 0 and 18 years of age and investigate the factors that affect growth including congenital heart disease (CHD) and hypothyroidism. Longitudinal measurements of height, weight, and head circumference (HC) were assessed and accompanying major malformations were recorded. ...
Liu Liyan - - 2012
A procedure was evaluated for the extraction of 16 free fatty acids (FFAs) from liver. Ultrasonic energy was used for the extraction and the variables affecting the extraction efficiency were investigated. The best conditions for extraction were: 2 mL isopropanol-n-hexane (3:2, v/v), 20 min and 80 w. Recoveries ranging from ...
Mafuba Kay - - 2012
This paper explores and advocates the use of sequential multiple methods as a contemporary strategy for undertaking research. Sequential multiple methods involve the use of results obtained through one data collection method to determine the direction and implementation of subsequent stages of a research project (Morse, 1991; Morgan, 1998). This ...
Wheeler Megan - - 2012
Enzymatic recognition of SeLNA nucleotides was investigated. KOD XL DNA polymerase was found to be an efficient enzyme in primer extension reactions. Polymerase chain reaction (PCR) amplification of SeLNA-modified DNA templates was also efficiently achieved by Phusion and KOD XL DNA polymerases.
- - 2012
As the US presidential campaign heads into the final stretch before the election in November, advocacy groups in Washington, DC, have ramped up their calls on the candidates to support science. One such group is Research!America, a nonpartisan alliance that strives to put health research high on the political agenda. ...
Zeisel Amit - - 2012
Collective migration is an important cellular trait, which is intensely studied by both basic and translational researchers. Investigation of the underlying mechanisms necessitates high-throughput assays and computational algorithms capable of generating reproducible quantitative measurements of cell migration. We present a desktop tool that can be used easily by any researcher, ...
Kerl Hans U - - 2012
Object Reliable visualization of the subthalamic nucleus (STN) is indispensable for accurate placement of electrodes in deep brain stimulation (DBS) surgery for patients with Parkinson disease (PD). The aim of the study was to evaluate different promising new MRI methods at 3.0 T for preoperative visualization of the STN using ...
Moustafa Abdel Halim A - - 2012
Thioacetamide (TAA) is a potent hepatotoxin that causes centrilobulal necrosis and nephrotoxic damage following acute administration. Prolonged exposure to TAA can result in bile duct proliferation and liver cirrhosis histologically similar to that caused due to viral hepatitis infection. Coriander in food increases the antioxidant content, acting as a natural ...
Abusaada Muath - - 2012
The modeling of groundwater flow in karst aquifers is a challenge due to the extreme heterogeneity of its hydraulic parameters and the duality in their discharge behavior, that is, rapid response of highly conductive karst conduits and delayed drainage of the low-permeability fractured matrix after recharge events. There are a ...
Abramov Yoram - - 2012
We aimed to determine whether cells obtained from malignant ovarian tumors had different ex vivo 1H- and 31P (phosphorus-31)-magnetic resonance (MR) spectra compared to cells obtained from benign ovarian cysts. In addition, we aimed to assess the metabolic effects of chemotherapy on malignant cells obtained from peritoneal effusions of ovarian cancer patients. We included ...
Vinogradova Ekaterina V - - 2012
The first synthesis and self-organization of zinc β-phosphorylporphyrins in the solid state and in solution are reported. β-Dialkoxyphosphoryl-5,10,15,20-tetraphenylporphyrins and their Zn(II) complexes have been synthesized in good yields by using Pd- and Cu-mediated carbon-phosphorous bond-forming reactions. The Cu-mediated reaction allowed to prepare the mono-β-(dialkoxyphosphoryl)porphyrins 1 Zn-3 Zn starting from the β-bromo-substituted zinc ...
Sakuratani Y - - 2012
Adoption of the data-gap filling method for complex endpoints such as repeated dose toxicity (RDT) and reproductive/developmental toxicity is one of the most important issues affecting international chemical management at present. A categorization method based on adverse outcome pathways (AOPs) has recently been investigated for such complex endpoints. In this ...
Verhagen A J - - 2012
Random item effects models provide a natural framework for the exploration of violations of measurement invariance without the need for anchor items. Within the random item effects modelling framework, Bayesian tests (Bayes factor, deviance information criterion) are proposed which enable multiple marginal invariance hypotheses to be tested simultaneously. The performance ...
Iwata M - - 2012
BACKGROUND: /st>Post-ischaemic benzodiazepine administration is neuroprotective, but chronic administration of benzodiazepines can induce tolerance, such that the neuroprotective effect may be reduced. This study investigated whether benzodiazepine tolerance can worsen ischaemic injury and whether neuroprotection by post-ischaemic benzodiazepine administration is affected by benzodiazepine tolerance. We also investigated whether antagonism of ...
Kato Satoshi - - 2012
Several surgical procedures have been developed to treat thoracic ossification of the posterior longitudinal ligament (OPLL). However, favorable surgical results are not always achieved, and consistent protocols and procedures for surgical treatment of thoracic OPLL have not been established. This technical note describes a novel technique to achieve anterior decompression ...
Dupuis Nina - - 2012
Smith-McCort dysplasia (SMC) is a rare autosomal recessive spondylo-epi-metaphyseal dysplasia with skeletal features identical to those of Dyggve-Melchior-Clausen syndrome (DMC) but with normal intelligence and no microcephaly. Although both syndromes were shown to result from mutations in the DYM gene, which encodes the Golgi protein DYMECLIN, a few SMC patients ...
Li Guifei - - 2012
An efficient rhodium-catalyzed tandem C-H bond olefination and annulation approach was developed to afford 1,2-dihydrophthalazines in good to excellent yields from easily accessible sulfonylhydrazones and alkenes.
Cates Daniel - - 2012
OBJECTIVES/HYPOTHESIS: Dysfunction of the upper esophageal sphincter (UES) is a common cause of oral-pharyngeal dysphagia (OPD). Dilation is a primary treatment, although current techniques are subject to a high rate of failure and recurrence. Devices available for UES dilation are cylindrical and were designed to distend the round lumen of ...
Wieten R W - - 2012
Rabies is a deadly disease, and current pre-exposure vaccination schedules are lengthy and expensive.We identified nine studies investigating abbreviated schedules. Although initial responses were lower, accelerated, adequate immune responses were elicited after booster vaccinations.Lower-dosed (and therefore cheaper) vaccination schedules may constitute a valid alternative to current vaccination schedules.
Thomas Joseph P - - 2012
Self-assembly of thiol-modified oligonucleotides on Au films has great importance for biosensor applications. Prior to the self-assembly, a piranha treatment (PT) is commonly used to clean the Au surface. Here we report that near-surface oxidized sulfur modifications on Au thin films by PT for longer than 60 s have serious ...
Nicklisch Nicole - - 2012
As an infectious disease, tuberculosis (TB) is one of the major causes of death worldwide. Paleopathological and paleomicrobiological studies indicate a long standing association of the causative agent Mycobacterium tuberculosis and its human host. Since the occurrence and the epidemic spread of this pathogen seem to be closely linked to ...
Horiguchi Daisuke - - 2012
Butyl methacrylate (BMA)-ethylene dimethacrylate (EDMA)-methacrylic acid (MAA) and BMA-EDMA-2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS) monolithic columns were prepared by varying the percentage of ionic monomers for capillary electrochromatography. Monolithic columns with a higher content of ionic monomers provided better column efficiency, and the performance of BMA-EDMA-MAA monoliths was better than BMA-EDMA-AMPS. To characterize ...
Kaura Mamta - - 2012
Oligonucleotides modified with consecutive incorporations of 5-(1-aryl-1,2,3-triazol-4-yl)-2'-deoxyuridine monomers display strong thermal affinity and binding specificity toward RNA targets, due to formation of chromophore arrays in the major groove.
Olmos José M - - 2012
Objective:Our objective was to know the extent to which a fall in bone turnover markers is influenced by serum 25-hydroxyvitamin D (25OHD) levels in patients on alendronate (ALN) treatment.Design, Participants, and Setting:A total of 140 postmenopausal osteoporotic women were randomized to receive either ALN or ALN plus 25OHD(3) (ALN+VitD) over ...
Levanon Yafa - - 2012
Typing is associated with musculoskeletal disorders (MSDs) caused by multiple risk factors. This control study aimed to evaluate the efficacy of a workplace intervention for reducing MSDs among computer workers. Sixty-six subjects with and without MSD were assigned consecutively to one of three groups: ergonomics intervention (work site and body ...
Crall Timothy S - - 2012
PURPOSE: The purpose of this study was to compare the cost-effectiveness of initial observation versus surgery for first-time anterior shoulder dislocation. METHODS: The clinical scenario of first-time anterior glenohumeral dislocation was simulated using a Markov model (where variables change over time depending on previous states). Nonoperative outcomes include success (no ...
Vasquez Eduardo A - - 2012
Four studies present the first evidence showing that public (vs. private) provocation augments triggered displaced aggression by increasing the perceived intensity of the provocation. This effect is shown to be independent of face-saving motivation. Following a public or private provocation, Study 1 participants were induced to ruminate or were distracted ...
Passaretti Catherine L - - 2012
Background. Admission to a room previously occupied by a patient with certain multidrug-resistant organisms (MDROs) increases the risk of acquisition. Traditional cleaning strategies do not remove all environmental MDROs. We evaluated the environmental and clinical impact of hydrogen peroxide vapor (HPV) room disinfection.Methods. We performed a 30-month prospective cohort intervention study on ...
Madiwale Gaurav P - - 2012
Potatoes can be stored for up to one year before being processed and consumed. The objective of this study was to determine the extent to which fresh and stored color-fleshed potatoes retain their anti-cancer properties after baking and chipping compared with unprocessed potatoes. We utilized white-, yellow- and purple-fleshed potato ...
Weitz Charles A - - 2012
This set of cross-sectional and longitudinal data from children and young adults in certain Bougainville and Solomon Islands populations undergoing rapid modernization during the period 1966-1986 reveals very different responses to essentially the same stimuli-the introduction and widespread availability of western dietary items and reductions in habitual activity. Our analyses ...
Byron Sara A - - 2012
ABSTRACT: BACKGROUND: Melanoma is the most lethal form of skin cancer, but recent advances in molecularly targeted agents against the Ras/Raf/MAPK pathway demonstrate promise as effective therapies. Despite these advances, resistance remains an issue, as illustrated recently by the clinical experience with vemurafenib. Such acquired resistance appears to be the ...
Rabkin Judith - - 2012
Our objective was to determine whether substantial differences in rates of TIV utilization in the U.S. and Japan are associated with the role of the treating neurologist. Questionnaires in English and Japanese were sent to neurologists who treated ALS patients in both countries. Questions included queries about rates of TIV ...
Bailey Ulla-Maja - - 2012
Asparagine-linked glycosylation is a common post-translational modification of proteins in eukaryotes. Mutations in the human ALG3 gene cause changed levels and altered glycan structures on mature glycoproteins, and are the cause of a severe Congenital Disorder of Glycosylation (CDG-Id). Diverse glycoproteins are also underglycosylated in Saccharomyces cerevisae alg3 mutants. Here ...
Ni Ruiqing - - 2012
The nicotinic receptors (nAChRs), which play a critical role in cognitive function, are impaired early in the course of Alzheimer's disease (AD). We have previously demonstrated that amyloid-β (Aβ) assemblies bind to α7 nAChRs and form complexes in AD brain, suggesting that this cooperative process may contribute to disruption of ...
Franco Carolina - - 2012
ABSTRACT: BACKGROUND: Friedreich s ataxia (FRDA) is a neurodegenerative disease caused by deficiency of the mitochondrial iron chaperone frataxin (Fxn). FRDA has no cure, but disease-modifying strategies to increase frataxin are under study. Because insulin-like growth factor I (IGF-I) has therapeutic effects in various types of cerebellar ataxia and exerts ...
Ghislin Stephanie - - 2012
ABSTRACT: BACKGROUND: Patients with metastatic melanoma have a poor median rate of survival. It is therefore necessary to increase our knowledge about melanoma cell dissemination which includes extravasation, where cancer cells cross the endothelial barrier. Extravasation is well understood during travelling of white blood cells, and involves integrins such as ...
Huang Wen-Shih - - 2012
Obesity has been shown to be associated with the risk of colorectal cancer (CRC). Adipokines produced by the adipose tissue are linked to some malignancies, including CRC. Visfatin is an adipokine shown to be a biomarker of CRC malignant potential. In addition, the stromal cell-derived factor-1 (SDF-1) has been reported ...
Stellwagen Lisa M - - 2012
Abstract Objective: We hypothesized that pooling a mother's expressed breastmilk for 24 hours compared with individual pump session collection of milk would provide a more consistent caloric product without increasing bacterial contamination. Study Design: We investigated 24-hour pooled breastmilk collection by enrolling 19 mothers who were expressing milk for their ...
Al-Sayed Eman M - - 2012
Cigarette smoke contains harmful chemicals with hazardous adverse effects on almost every organ in the body of smokers as well as of nonsmokers exposed to environmental tobacco smoke (ETS). There has been increasing interest in the effects of passive smoking on the health of children. In order to detect the ...
Dauwe Phillip - - 2012
Understanding online social networks is of critical importance to the plastic surgeon. With knowledge, it becomes apparent that the numerous networks available are similar in their structure, usage, and function. The key is communication between Internet media such that one maximizes exposure to patients. This article focuses on 2 social ...
Liu Xiao - - 2012
Side-group-exchange reactions have been studied for short-chain linear oligomeric phosphazenes, (RO)(4)P[N═P(OR(2))](n)OR (n = 6, 10, 20, and 40) as models for the corresponding linear high polymers (n ∼ 15000). Specifically, the exchange behavior of oligomers where OR = OCH(2)CF(3), OC(6)H(5), OC(6)H(4)CHO-p, OC(6)H(4)CN-p, and OC(6)H(4)NO(2)-p with sodium trifluoroethoxide was examined. The ...
Parkkinen Pauli Mikael - - 2012
A graph-theoretical analysis is performed on the (H(2)O)(20) "edge-sharing pentagonal prism" cluster to find proton configurations which yield the lowest cluster total energies. Using the low-energy structures, we create models for protonated (H(2)O)(20) H(+) clusters which compete energetically with ``cage-like'' structures proposed earlier in the literature. We perform benchmarking between ...
Wu Wenyu - - 2012
A multifunctional nanosensor based on silica nanoparticles has been designed by importing metal binding sites and hydrogen bonds directly attached to the chromophore. It works well in the recognition of Hg(2+), H(2)PO(4)(-), S(2-)via different combination mechanisms, and intracellular imaging.
Pućko Monika - - 2012
During the summer of 2009, we sampled 14 partially re-frozen melt ponds and the top 1 m of old ice in the pond vicinity for α-hexachlorocyclohexane (α-HCH) concentrations and enantiomer fractions (EFs) in the Beaufort Sea. α-HCH concentrations were 3 - 9 times higher in melt ponds than in the ...
Rosenbaum Susann - - 2012
ABSTRACT: BACKGROUND: It has recently been shown that the lactation-induced inflammatory state in the liver of dairy cows is accompanied by activation of the nuclear factor E2-related factor 2 (Nrf2) pathway, which regulates the expression of antioxidant and cytoprotective genes and thereby protects tissues from inflammatory mediators and reactive oxygen ...
< 10 11 12 13 14 15 16 17 18 19 20 >