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Results 701 - 750 of 3450
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Leontijevic B - - 2012
A novel loading method (loading ranged from 20% to 80% of 1RM) was applied to explore the selective effects of externally added simulated weight (exerted by stretched rubber bands pulling downward), weight+inertia (external weights added), and inertia (covariation of the weights and the rubber bands pulling upward) on maximum bench ...
Ramon Sesquile S Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, - - 2012
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. PPARγ, a ligand-activated transcription factor, has important anti-inflammatory and antiproliferative functions, and it has been associated with diseases including diabetes, scarring, and atherosclerosis, among others. PPARγ is expressed in most bone marrow-derived cells and influences their function. PPARγ ...
Ueyama Eiji - - 2012
In this study, the degradates generated from a pharmaceutical solid were characterized, and a mechanistic pathway underlying their formation was proposed. The chemical stability of a novel triazole antifungal drug, CS-758, deteriorated significantly when the crystal was disordered, and characteristic degradates were generated. A total of eight degradates in solution ...
Lim Ai Lin AL Department of Growth Development and Metabolism, Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A-STAR), Singapore, - - 2012
Genomic imprinting is a process causing genes to be expressed according to parental origin. Imprinting acts to coordinate fetal and prenatal growth, as well as control postnatal adaptations. Studies on human imprinting are confounded by tissue availability, sampling variability and limitations posed by tissue-specific expression and cellular heterogeneity within tissues. ...
Tilden Virginia P VP College of Nursing, University of Nebraska Medical Center, Omaha, NE 68198-5330, - - 2013
Research on end-of-life care in nursing homes is hampered by challenges in retaining facilities in samples through study completion. Large-scale longitudinal studies in which data are collected on-site can be particularly challenging. To compare characteristics of nursing homes that dropped from the study to those that completed the study. One ...
Cordeiro Marco Aurelio Liutheviciene - - 2012
In this study, some keys in the knowledge of nanocrystals dissolving by the direct phenomenon observations are provided through in situ transmission electron microscopy experiments. The new characteristic of anisotropic nanoparticles dissolving is discussed and correlated with the evolution of the crystal to reach a minimum surface free energy (Gibbs-Wulff ...
Duman Ronald S - - 2012
Basic and clinical studies demonstrate that depression is associated with reduced size of brain regions that regulate mood and cognition, including the prefrontal cortex and the hippocampus, and decreased neuronal synapses in these areas. Antidepressants can block or reverse these neuronal deficits, although typical antidepressants have limited efficacy and delayed ...
Wang Fang-Fang - - 2012
A practical Brønsted acid promoted benzylic C-H functionalization of 2-methylazaarenes and nucleophilic addition to aldehydes was developed in good to excellent yields. A six-membered hydrogen-bonding transition state is proposed to be crucial for the reaction. Ready availability of the two starting materials, the use of acetic acid as the catalyst ...
Lu Jingtao J Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, - - 2013
Amiodarone (AMD), a class III antiarrhythmic drug, causes idiosyncratic hepatotoxicity in human patients. We demonstrated previously that tumor necrosis factor-alpha (TNF-α) plays an important role in a rat model of AMD-induced hepatotoxicity under inflammatory stress. In this study, we developed a model in vitro to study the roles of caspase ...
Ipata Anna E - - 2012
A hallmark of visual cortical neurons is their selectivity for stimulus pattern features, such as color, orientation, or shape. In most cases this feature selectivity is hard-wired, with selectivity manifest from the beginning of the response. Here we show that when a task requires that a monkey distinguish between patterns, ...
Zhang Botao B Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, - - 2012
The Arabidopsis thaliana genome contains two genes with homology to the mitochondrial protein LETM1 (leucine zipper-EF-hand-containing transmembrane protein). Inactivation of both genes, Atletm1 and Atletm2, together is lethal. Plants that are hemizygous for AtLETM2 and homozygous for Atletm1 (letm1(-/-) LETM2(+/-)) displayed a mild retarded growth phenotype during early seedling growth. ...
Verghese Joe - - 2012
To develop and validate a picture-based memory impairment screen (PMIS) for the detection of dementia. Cross-sectional. Outpatient clinics, Baby Memorial Hospital, Kozhikode city in the southern Indian state of Kerala. Three hundred four community-residing adults aged 55 to 94 with a mean education level of 8 years; 65 were diagnosed ...
Hijazin Muaz - - 2012
A polyphasic taxonomic study was performed on two previously unidentified Arcanobacterium-like Gram-positive strains isolated from harbour seals. Comparative 16S rRNA gene sequencing showed that both bacteria belonged to genus Arcanobacterium and were most closely related to Arcanobacterium haemolyticum (98.4%), Arcanobacterium canis and Arcanobacterium phocae (97.4%), Arcanobacterium pluranimalium (95.7%) and Arcanobacterium ...
Yoon Jung-Hoon - - 2012
A Gram-staining-negative, non-flagellated, non-gliding and rod-shaped bacterial strain, designated PDB-16T, was isolated from seawater from a seaweed farm on the South Sea in Korea, and its taxonomic position was investigated by using a polyphasic study. Strain PDB-16T grew optimally at 30 °C, at pH 7.0-7.5 and in the presence of ...
Wang Yiru - - 2012
The aim of this study was to establish a method for the determination of hexanal as a lipid oxidation marker in rice. For the sample preparation, ground rice exhibited better sensitivity and reproducibility for the analysis of hexanal than whole rice. A total flow of purge gas of 300 mL ...
Yang Eun-Ju - - 2012
High mobility group box 1 (HMGB1) protein is a crucial cytokine that mediates response to infection, injury, and inflammation. Rosmarinic acid (RA) is an important component of the leaves of Perilla frutescens and has neuroprotective, anti-microbial, anti-oxidant, and anti-cancer effects but little is known of its effects on HMGB1-mediated inflammatory ...
Semrau Robert - - 2012
BACKGROUND: The influence of human papillomavirus (HPV) status on survival for patients with very advanced inoperable oropharyngeal SCC treated with radiochemotherapy (RCT) was studied. METHODS: Patients received either 69.2 Gy with concomitant boost (ccb) or 70 Gy conventionally fractionated (cf), weekly paclitaxel 40 mg/m(2) , and carboplatin area under the ...
Jonek Anita - - 2012
Ruthenium-catalyzed allylation-cyclization reactions of cyclic 1,3-dicarbonyl compounds with 1-vinyl propargyl alcohols that lead to diverse carbo- or heterocyclic products in a one-pot cascade process are reported. These mechanistically distinct reactions are catalyzed by a single ruthenium(0) complex that contains a redox-coupled dienone ligand. The reaction pathway strongly depends on the ...
Klekamp Jörg - - 2012
Object Decompression of the foramen magnum is widely accepted as the procedure of choice for patients with Chiari malformation Type I (CM-I). This study was undertaken to determine the mechanisms responsible for neurological deterioration after foramen magnum decompression and the results of secondary interventions. Methods Between 1987 and 2010, 559 ...
Oates Stori C - - 2012
The risk of disease transmission from waterborne protozoa is often dependent on the origin (e.g., domestic animals versus wildlife), overall parasite load in contaminated waterways, and parasite genotype, with infections being linked to runoff or direct deposition of domestic animal and wildlife feces. Fecal samples collected from domestic animals and ...
Macneill Christopher M - - 2012
Low band gap D-A conjugated PNs consisting of 2-ethylhexyl cyclopentadithiophene co-polymerized with 2,1,3-benzothiadiazole (for nano-PCPDTBT) or 2,1,3-benzoselenadiazole (for nano-PCPDTBSe) have been developed. The PNs are stable in aqueous media and showed no significant toxicity up to 1 mg · mL(-1) . Upon exposure to 808 nm light, the PNs generated temperatures above 50 °C. ...
Zinman Bernard B Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, - - 2012
To compare ultra-long-acting insulin degludec with glargine for efficacy and safety in insulin-naive patients with type 2 diabetes inadequately controlled with oral antidiabetic drugs (OADs). In this 1-year, parallel-group, randomized, open-label, treat-to-target trial, adults with type 2 diabetes with A1C of 7-10% taking OADs were randomized 3:1 to receive once ...
Alves Luis G - - 2012
Novel Bn(2)Cyclam-based zirconium complexes of the type (Bn(2)Cyclam)Zr(X)(X') (, X = X' = OPh; , X = X' = SPh; , X = Cl, X' = O(i)Pr) were synthesized in good yields via metathesis routes involving the reaction of the dichloro precursor (Bn(2)Cyclam)Zr(Cl)(2) and the appropriate lithium salts. The molecular ...
Huang Li-Kuo - - 2013
Statin-induced lung injury (SILI) is an uncommon but serious complication of statins. The clinical features and outcome of patients with SILI vary widely. Clinical data relevant to diagnosis and outcome of patients with SILI were investigated in this study. Four cases of SILI diagnosed at our institute and 12 cases ...
Montes Jacqueline - - 2013
Falls can cause injury and may compromise function in spinal muscular atrophy (SMA) patients. Weakness and gait variability are associated with falls in other neurological disorders, and fatigue is well documented in SMA. The relationship of weakness, fatigue, and gait variability to falls has never been investigated. Seven ambulatory patients ...
Sadeghi Banafsheh - - 2012
BACKGROUND: The FDA-approved dose of low-molecular-weight heparin (LMWH) may not provide adequate thromboprophylaxis in morbidly obese patients after total knee arthroplasty (TKA). Suboptimal dosing, delayed initiation, and overreliance on mechanical methods may also limit the effectiveness of thromboprophylaxis. OBJECTIVE: We explored the associations between the type of thromboprophylaxis, obesity, time ...
Morley John E - - 2012
PURPOSE OF REVIEW: Anorexia represents a major problem for older persons leading to weight loss, sarcopenia, functional decline, and mortality. There is increasing information on the pathophysiological mechanisms that lead to anorexia. RECENT FINDINGS: Increasing evidence has shown the importance of gastrointestinal hormones (ghrelin, cholecystokinin, and glucagon-like peptide) and adipokines ...
Galeone C - - 2012
BackgroundAlcohol is capable of traversing the blood-brain barrier and is thus a possible risk factor for brain cancer. Several epidemiological studies have been published on the issue, a number of those during recent years, with inconsistent findings.Materials and methodsWe performed a systematic literature search in the Medline and EMBASE databases. ...
Daniels Christopher R CR Department of Biomedical Sciences, James H. Quillen College of Medicine, James H. Quillen Veterans Affairs Medical Center, East Tennessee State University, Johnson City, Tennessee, - - 2012
β-Adrenergic receptor (β-AR) stimulation increases extracellular ubiquitin (UB) levels, and extracellular UB inhibits β-AR-stimulated apoptosis in adult cardiac myocytes. This study investigates the role of exogenous UB in chronic β-AR-stimulated myocardial remodeling. l-Isoproterenol (ISO; 400 μg·kg(-1)·h(-1)) was infused in mice in the presence or absence of UB (1 μg·g(-1)·h(-1)). Left ...
El Hady Hala Mostafa - - 2012
The aim of the present study was to find out the potential impact of occupational exposure to mixtures of organic solvents on liver function tests. Serum bile acid (BA) was evaluated as a marker of early hepatic derangement and compared to routine liver function tests. The study included two comparable ...
El-Khalawany Mohamed - - 2012
Helicobacter pylori was incriminated as an etiological factor of rosacea. However, there is still controversy about this association. We conducted a comparative study in order to assess the role of H. pylori in rosacea patients who had dyspeptic symptoms. The study included 68 patients and 54 controls. Screening for H. pylori was ...
Yuan Tong-Qi - - 2012
Although the effects of cellulose crystallinity and lignin content as two major structural features on enzymatic hydrolysis have been extensively studied, debates regarding their effects still exist. In this study, reconstitution of cellulose and lignin after 1-ethyl-3-methylimidazolium acetate ([C(2) mim][OAc]) pretreatment was proposed as a new method to study their ...
Tu Huang-Ju - - 2012
OncostatinM (OSM) belongs to IL-6 subfamily and is mostly produced by T lymphocytes. High levels of OSM are detected in the pannus of rheumatoid arthritis (RA) patients and it may arouse the inflammation responses in joints and eventually leads to bone erosion. Placenta growth factor (PLGF) is an angiogenic factor ...
Yan Xiaoyu - - 2012
A super pyrazolate: deprotonation of the flanking hydrogen of metal complexes of mesoionic carbenes (MICs) offers a simple and general route for the preparation of bimetallic complexes of a 1,2-dihapto anionic dicarbene ligand that is isoelectronic with widely used pyrazolate ligands, while conferring greater electron donation and stronger M-L bonds.
Dessapt A-L AL Centre d'assistance médicale à la procréation, centre intercommunal de Créteil, 40 avenue de Verdun, Créteil, France. - - 2012
Estrogenic deficiency of menopause is not only responsible to the precocious occurrence of climateric troubles but exposes at increased risk of osteoporosis, metabolic troubles, and cardiovascular complications. We believed for a long time that the hormonal treatment prescription could prevent cardiovascular risk. Then, initial analysis of the great controlled study ...
Delubac Daniel - - 2012
Drosophila is one of the most important model organisms in biology. Knowledge derived from the recently sequenced 12 genomes of various Drosophila species can today be combined with the results of more than 100 years of research to systematically investigate Drosophila biology at the molecular level. In order to enable ...
Paradis France-Hélène - - 2013
In utero exposure to valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, causes neural tube, heart, and limb defects. Valpromide (VPD), the amide derivative of VPA, does not inhibit HDAC activity and is a weak teratogen in vivo. The detailed mechanism of action of VPA as a teratogen is not ...
Ghislin Stephanie - - 2012
ABSTRACT: BACKGROUND: Patients with metastatic melanoma have a poor median rate of survival. It is therefore necessary to increase our knowledge about melanoma cell dissemination which includes extravasation, where cancer cells cross the endothelial barrier. Extravasation is well understood during travelling of white blood cells, and involves integrins such as ...
Yang Qiwei Q Department of Pediatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. - - 2012
High-altitude long-term hypoxia (LTH) is known to induce pulmonary arterial smooth muscle cell (PASMC) proliferation in the fetus, leading to pulmonary arterial remodeling and pulmonary hypertension of the newborn. The mechanisms underlying these conditions remain enigmatic however. We hypothesized that epigenetic alterations in fetal PASMC induced by high-altitude LTH may ...
Nasie Iris - - 2012
Transporters of the small multidrug resistance (SMR) family are small homo- or heterodimers that confer resistance to multiple toxic compounds by exchanging substrate with protons. Despite the wealth of biochemical information on EmrE, the most studied SMR member, a high-resolution three-dimensional structure is missing. To provide proteins that are more ...
Huang Wen-Shih - - 2012
Obesity has been shown to be associated with the risk of colorectal cancer (CRC). Adipokines produced by the adipose tissue are linked to some malignancies, including CRC. Visfatin is an adipokine shown to be a biomarker of CRC malignant potential. In addition, the stromal cell-derived factor-1 (SDF-1) has been reported ...
Stellwagen Lisa M - - 2012
Abstract Objective: We hypothesized that pooling a mother's expressed breastmilk for 24 hours compared with individual pump session collection of milk would provide a more consistent caloric product without increasing bacterial contamination. Study Design: We investigated 24-hour pooled breastmilk collection by enrolling 19 mothers who were expressing milk for their ...
Schilling Joel D JD Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, MO 63110, - - 2012
Diabetes is associated with myocardial lipid accumulation and an increased risk of heart failure. Although cardiac myocyte lipid overload is thought to contribute to the pathogenesis of cardiomyopathy in the setting of diabetes, the mechanism(s) through which this occurs is not well understood. Increasingly, inflammation has been recognized as a ...
Al-Sayed Eman M - - 2012
Cigarette smoke contains harmful chemicals with hazardous adverse effects on almost every organ in the body of smokers as well as of nonsmokers exposed to environmental tobacco smoke (ETS). There has been increasing interest in the effects of passive smoking on the health of children. In order to detect the ...
Dauwe Phillip - - 2012
Understanding online social networks is of critical importance to the plastic surgeon. With knowledge, it becomes apparent that the numerous networks available are similar in their structure, usage, and function. The key is communication between Internet media such that one maximizes exposure to patients. This article focuses on 2 social ...
Liu Xiao - - 2012
Side-group-exchange reactions have been studied for short-chain linear oligomeric phosphazenes, (RO)(4)P[N═P(OR(2))](n)OR (n = 6, 10, 20, and 40) as models for the corresponding linear high polymers (n ∼ 15000). Specifically, the exchange behavior of oligomers where OR = OCH(2)CF(3), OC(6)H(5), OC(6)H(4)CHO-p, OC(6)H(4)CN-p, and OC(6)H(4)NO(2)-p with sodium trifluoroethoxide was examined. The ...
Parkkinen Pauli Mikael - - 2012
A graph-theoretical analysis is performed on the (H(2)O)(20) "edge-sharing pentagonal prism" cluster to find proton configurations which yield the lowest cluster total energies. Using the low-energy structures, we create models for protonated (H(2)O)(20) H(+) clusters which compete energetically with ``cage-like'' structures proposed earlier in the literature. We perform benchmarking between ...
Wu Wenyu - - 2012
A multifunctional nanosensor based on silica nanoparticles has been designed by importing metal binding sites and hydrogen bonds directly attached to the chromophore. It works well in the recognition of Hg(2+), H(2)PO(4)(-), S(2-)via different combination mechanisms, and intracellular imaging.
Pućko Monika - - 2012
During the summer of 2009, we sampled 14 partially re-frozen melt ponds and the top 1 m of old ice in the pond vicinity for α-hexachlorocyclohexane (α-HCH) concentrations and enantiomer fractions (EFs) in the Beaufort Sea. α-HCH concentrations were 3 - 9 times higher in melt ponds than in the ...
Rosenbaum Susann - - 2012
ABSTRACT: BACKGROUND: It has recently been shown that the lactation-induced inflammatory state in the liver of dairy cows is accompanied by activation of the nuclear factor E2-related factor 2 (Nrf2) pathway, which regulates the expression of antioxidant and cytoprotective genes and thereby protects tissues from inflammatory mediators and reactive oxygen ...
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