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McBride Carl - - 2012
The melting point of ice I(h), as well as the temperature of maximum density (TMD) in the liquid phase, has been computed using the path integral Monte Carlo method. Two new models are introduced, TIP4PQ_D2O and TIP4PQ_T2O, which are specifically designed to study D(2)O and T(2)O respectively. We have also ...
Sunasee Rajesh - - 2012
With advances in polymerization techniques as well as selective chemical modification of carbohydrates, glycopolymers and glyco-nanoparticles are emerging as an important class of materials with tailored properties or novel nanotechnology-based platforms for a number of applications. The field of the so-called glyco-nanotechnology is starting to show some promises for future ...
Tripodi Armando - - 2012
BACKGROUND:The new oral anticoagulants (NOAs) dabigatran, rivaroxaban, and apixaban have proved effective and safe when used in clinical trials, without a need to adjust the dose in response to laboratory testing. This demonstrated efficacy does not necessarily mean that the laboratory, considered the mainstay for the management of the old ...
Zhang Meng - - 2012
An artificial peptide with three pendant hydroxyquinoline (hq) ligands on a palindromic backbone was designed and used to form multimetallic assemblies. Reaction of the tripeptide with zinc acetate led to a highly fluorescent tripeptide duplex with three Zn(II) coordinative cross-links. The binding process was monitored using spectrophotometric absorbance and emission ...
Banerjee S - - 2012
BackgroundThe aim of the study is to demonstrate that intrapatient dose escalation of carboplatin would improve the outcome in ovarian cancer compared with flat dosing.Patients and methodsPatients with untreated stage IC-IV ovarian cancer received six cycles of carboplatin area under the curve 6 (AUC 6) 3 weekly either with no ...
Ranatunga Sujeewa - - 2012
Lucentamycin A is a marine-derived peptide natural product harboring a unique 4-ethylidene-3-methylproline (Emp) subunit. The proposed structure of lucentamycin A and the core Emp residue have recently been called into question through synthesis. Here, we report the first total synthesis of lucentamycin A, which confirms that the ethylidene substituent in ...
Li Sidan - - 2012
The majority of hematopoietic stem/progenitor cells (HSPCs) reside in bone marrow (BM) surrounded by a specialized environment, which governs HSPC function. Here we investigated the potential role of bone remodeling cells (osteoblasts and osteoclasts) in homeostasis and stress-induced HSPC mobilization. Peripheral blood (PB) and BM in steady/mobilized state were collected ...
Schafer Markus H - - 2012
Despite the recent and rapid worldwide rise in body mass index (BMI), little empirical research outside the developed world has systematically considered the role of cohorts in inaugurating emergent biomorphic disparities. This study integrates aspects of the life course perspective (attention to age- and cohort-level influences) with fundamental cause theory ...
Wang Xiaoyong - - 2012
Platinum-based anticancer drugs occupy a crucial role in the treatment of various malignant tumours. However, the efficacy and applicability of platinum drugs are heavily restricted by severe systemic toxicities and drug resistance. Different drug targeting and delivery (DTD) strategies have been developed to prevent the shortcomings of platinum-based chemotherapy. These ...
Roser Florian - - 2012
Background Glossopharyngeal nerve neuralgia (GPN) is an exceptionally rare skull-based disorder. It is treated similar to other neurovascular conflicts. The approach, however, is debatable, as the caudal cranial nerves and especially the exit zones at the brainstem are barely visible via the retrosigmoid approach.Clinical Presentation We demonstrate a case of a typical ...
Peng Guo - - 2012
The first use of triethylene glycol (H(2)teg) in Fe/Ln chemistry affords two series of tetranuclear {Fe(III)(2)Ln(III)(2)} coordination clusters possessing defect-dicubane cores. A change in the synthetic procedure results in a different arrangement of the relative positions of the 3d and 4f elements offering a means to steer the structural and ...
Fessel Jeffrey - - 2012
Atraumatic osteonecrosis is a common complication of SLE and is seen in other connective tissue diseases, in patients treated with high doses of CSs, in HIV-infected patients and in alcoholic patients. Standard care is confined to analgesia, core decompression if the condition is early and affects the femoral head and ...
Koszarska Magdalena - - 2012
ABSTRACT Mutations of isocitrate dehydrogenase 1 and 2 (IDH1/2) are genetic alterations in acute myeloid leukemia (AML). The aim of our study was to investigate the frequency and prognostic effect of IDH1/2 mutations together followed by an individual analysis of each substitution in the Hungarian cohort consisting of 376 AML ...
Bowen Timothy - - 2012
MicroRNAs are short noncoding RNA regulators that repress synthesis of their targets post-transcriptionally. On average, each microRNA is estimated to regulate several hundred protein-coding genes, and about 60% of proteins are thought to be regulated by microRNAs in total. A subset of these genes, including the key profibrotic cytokine Transforming ...
Carius Lisa - - 2012
Bacterial growth under oxygen-limited (microaerobic) conditions is often accompanied by phenomena of great interest for fundamental research and industrial application. The microaerobic lifestyle of anoxygenic photosynthetic bacteria like Rhodospirillum rubrum harbors such a phenomenon, as it allows the formation of photosynthetic membranes and related interesting products without light. However, due ...
Gracanin Ana - - 2012
Progesterone regulates multiple behavioral, physiological, and pathological aspects of female reproductive biology through its two progesterone receptors (PRs), PR-B and the truncated PR-A. PR-B is necessary for mammary gland development in mice and, compared with PR-A, is overall a stronger transactivator of target genes due to an additional activation function ...
Smith V M - - 2012
Background  Nicorandil has been available in the U.K. since 1994 for the prophylaxis and treatment of angina. Since the first reported case of nicorandil-associated oral ulceration in 1997 complications elsewhere in the gastrointestinal tract have been reported. Objectives  Our case series highlights this serious drug complication. Methods  We reviewed the ...
Lin Po-Hung - - 2012
This study explored the effects of culture, ambient illumination, and resolution on perceived image quality and colourfulness of mobile displays. Thirty Taiwanese and 30 American students participated in the experiment. Two types of culture (Taiwanese and American), two types of illumination level (1500 lux and 7000 lux), and five types ...
Lee Eun Hui - - 2012
Angiopoietin 1 (Ang1) plays an important role in various endothelial functions, such as vascular integrity and angiogenesis; however, less is known about its function outside of the endothelium. In this study, we examined whether Ang1 has direct effects on skeletal muscle cells. We found that Ang1 exhibited myogenic potential, as ...
Kasimanickam V - - 2012
Although the existence of a complex population of mRNA in sperm is well documented, its role has not been completely elucidated. The objective of this study was to determine the relationship of mRNA abundance of sperm specific proteins and sire conception rates (SCR; a fertility index) in Holstein bulls. Samples ...
Wei Wei - - 2012
Channel hopping: We demonstrate the formation of WO(3) layers with an aligned nanochannel morphology using self-organizing anodization of a tungsten metal substrate. The nanochannel layers with diameters of approximately 9 nm can be grown to about 10 μm thickness. Layers optimized for length and structure yield are promising for visible-light photocatalytic applications, ...
Barker Nick - - 2012
Decades ago, two nonoverlapping crypt stem cell populations were proposed: Leblond's Crypt Base Columnar (CBC) cell and Potten's +4 cell. The identification of CBC markers including Lgr5 has confirmed Leblond's predictions that CBC cells are anatomically distinct, long-lived stem cells that permanently cycle. While Potten originally described +4 cells as ...
Kimura Hiroshi - - 2012
Noncatalytic hydrothermolyses of malto- and cello-oligosaccharides (di-, tri-, tetraose), linked by α- and β-1,4-glycosidic bonds, respectively, were investigated at 100-140 °C. In situ (13)C NMR spectroscopy was applied to elucidate the position and pathways of the glycosidic bond breakage and the dependence of the hydrolysis rate on the bond type. ...
Krini Maro - - 2012
Background:Celiac disease (CD) has been associated with HLA class II heterodimers. This study aimed at determining the HLA genotypic and allelic distribution in Greek children with CD compared to the general population.Methods:118 children with CD and 120 healthy individuals serving as controls were included in the study.Results:Higher frequencies for HLA ...
Kedem Moran Hausman - - 2012
Abstract Background: Little is known about the effect of maternal age on human milk (HM) composition. This study was designed to study fat content, estimated by creamatocrit (CMT), in HM collected in the first 2 weeks of life in older (≥35 years) compared with younger (<35 years) mothers. Study Design ...
Mao Jianwen - - 2012
Tamoxifen is a triphenylethylene non-steroidal antiestrogen anticancer agent. It also shows inhibitory effects on metastasis of estrogen receptor (EsR)-independent tumors, but the underlying mechanism is unclear. It was demonstrated in this study that, in EsR-negative and highly metastatic human hepatocellular carcinoma MHCC97H cells, tamoxifen inhibited cell migration, volume-activated Cl(-) currents ...
Stasch Andreas - - 2012
The new sterically demanding aminoiminophosphorane Ph(2) P(NDip)(NHDip) (Dip=C(6) H(3) -2,6-iPr(2) ; LH, 1) has been prepared as a precursor to the potassium complex [LK] (2) and a series of heteroleptic zinc(II) complexes, namely [(LZnBr)(2) ] (3), [LZnMe] (4), [LZnEt] (5), and [(LZnI)(2) ] (6). The products have been obtained either ...
Epa Vidana Chandana - - 2012
Products are increasingly incorporating nanomaterials, but we have a poor understanding of their adverse effects. To assess risk, regulatory authorities need more experimental testing of nanoparticles. Computational models play a complementary role in allowing rapid prediction of potential toxicities of new and modified nanomaterials. We generated quantitative, predictive models of ...
Kim Ggotpin - - 2012
Elevated homocysteine (Hcy) levels have been associated with an increased risk of cognitive impairment and Alzheimer's disease (AD). Tissue factor pathway inhibitor (TFPI) has recently emerged as a candidate marker of endothelial damage in AD. We investigated the relationship between plasma levels of folate, vitamin B12, Hcy, and TFPI, as ...
Bhaskar V - - 2012
XMetA, a high-affinity, fully human monoclonal antibody, allosterically binds to and activates the insulin receptor (INSR). Previously, we found that XMetA normalized fasting glucose and glucose tolerance in insulinopenic mice. To determine whether XMetA is also beneficial for reducing hyperglycemia due to the insulin resistance of obesity, we have now ...
Kitoh-Nishioka Hirotaka - - 2012
The tunneling mechanisms of electron transfers (ETs) in photosynthetic reaction center of Blastochloris viridis are studied by the ab initio fragment molecular orbital (FMO) method combined with the generalized Mulliken-Hush (GMH) and the bridge Green function (GF) calculations of the electronic coupling T(DA) and the tunneling current method for the ...
Choi Soo-Han - - 2012
BACKGROUND: Invasive aspergillosis (IA) is a major cause of morbidity and mortality in immunocompromised children. We investigated the usefulness of an Aspergillus galactomannan (GM) antigen assay as a diagnostic tool for IA in pediatric cancer patients and hematopoietic cell transplantation (HCT) recipients. PROCEDURE: The GM antigen assay results were analyzed ...
Dolan John R - - 2012
Ciliate microzooplankton are important grazers in most pelagic ecosystems and among them, tintinnids, with their largely species-specific loricas, allow relatively easy assessment of questions of diversity and distributions. Herein, we present the results of a survey of species records of tintinnids from the Southern Ocean (locations below 40°S) reported in ...
Skinner Mark F - - 2012
Periodicity of repetitive linear enamel hypoplasia (rLEH) in apes from high latitudes with single wet and dry seasons annually has not been described. We reconstruct periodicity and duration of rLEH in canine teeth from three recently deceased chimpanzees from Fongoli, Senegal with a marked seven-month dry season. High-resolution dental molds ...
Banerjee Ananda - - 2012
Conventional droplet generation approaches in digital microfluidics show ~10% variation in droplet volumes and are restricted to creating only small volumes. In this work, we demonstrate a new approach for splitting sample volumes precisely by gradually ramping down voltage, in place of abruptly switching off electrodes. This allows us to ...
Niclasen Birgit - - 2012
Aim: The aim of this study was to examine how vigorous physical activity (recreational physical activity) (VPA) and moderate to vigorous physical activity as a part of daily life (MVPA) is associated with structural characteristics (availability of sports facilities and sports clubs with child members) in Greenlandic adolescents. Material and ...
Holzmann David - - 2012
Background The impact of transnasal endoscopic approaches to the central skull is still increasing. Its use in small children (i.e., under the age of 5 years) is of questionable value.Patients and Methods The present study is a description of a series of five children under the age of 5 years with lesions ...
Aronson Paul L - - 2012
  There is concern that the use of topical corticosteroids in patients with eczema herpeticum may facilitate dissemination of herpes simplex virus and worsen disease. Our primary aim therefore was to determine whether topical corticosteroid use in children hospitalized with eczema herpeticum is associated with longer hospital length of stay ...
Durante Federica - - 2012
Income inequality undermines societies: The more inequality, the more health problems, social tensions, and the lower social mobility, trust, life expectancy. Given people's tendency to legitimate existing social arrangements, the stereotype content model (SCM) argues that ambivalence-perceiving many groups as either warm or competent, but not both-may help maintain socio-economic ...
J Armstrong P C - - 2012
Systemic Staphylococcus (S.) aureus infections are associated with disseminated intravascular coagulation (DIC), a disorder characterised by simultaneous thrombosis and bleeding, which ultimately leads to multiple organ failure and thrombocytopenia [1]. S. aureus secretes pathogenic proteins including the Staphylococcal superantigen-like proteins (SSLs); a protein family structurally homologous to the superantigens (SAg). ...
Nooka A K - - 2012
BackgroundBecause follicular lymphoma (FL) patients have heterogeneous outcomes, the FL international prognostic index (FLIPI) was developed to risk-stratify patients and to predict survival. However, limited data exist regarding the role of FLIPI in the era of routine first-line rituximab (R) and R-chemotherapy regimens and in the setting of community oncology ...
Wallis Robert S - - 2012
Six new anti-tuberculosis compounds in 4 classes are presently in clinical trials. Although these show substantial promise for drug-resistant (DR) tuberculosis, the presently planned studies of these compounds will not inform their optimal use, as each will be tested singly vs. placebo with existing drugs, rather than in new regimens. ...
Alderman Sarah L - - 2012
The type 2 11β-hydroxysteroid dehydrogenase (11βHSD2) converts active glucocorticoids to their inactive derivatives (ex. cortisol to cortisone). In most vertebrates, 11βHSD2 is essential for conferring aldosterone-specific actions in mineralocorticoid target tissues and for protecting glucocorticoid-sensitive tissues during stress. However, teleosts do not synthesize aldosterone, and the function of 11βHSD2 is ...
Ragab Marwa A A - - 2012
A simple, precise, accurate and robust high-performance liquid chromatography assay was developed and validated for the simultaneous analysis of metoclopramide and paracetamol in human urine. The drugs were isolated from urine samples by solid-phase extraction using C8 cartridges, then analyzed on a C18 reversed-phase column using a mixture of aqueous ...
Vanden Hoek A L - - 2012
Factor Xa (FXa) is a critical blood coagulation enzyme that is activated by proteolysis from its precursor factor X (FX) [1]. The generation of FXa is initiated by tissue factor (TF)/factor VIIa (FVIIa)-dependent extrinsic tenase complex and then amplified by factor VIIIa (FVIIIa)/factor IXa (FIXa)-dependent intrinsic tenase complex. Thus, FX ...
Gustafsson Sheppard Nina - - 2012
Estrogen receptor-α (ERα) is initially overexpressed in two-thirds of all breast cancer and is involved in its development and proliferation. We previously reported that the RBCC protein interacting with PKC 1 (RBCK1) interacts with the ERα promoter and that RBCK1 expression positively correlates with ERα levels, expression of ERα downstream ...
Lamani Manjunath - - 2012
Single-step amination: The N-iodosuccinimide (NIS)-catalyzed amidation of acetophenone derivatives by using tert-butylhydroperoxide (TBHP) as an oxidant is presented. A variety of acetyl derivatives of heterocyclic compounds were easily converted to their corresponding ketoamides under these conditions. A new, NIS-catalyzed amination of propiophenone and its derivatives in the presence of TBHP ...
Froestl Wolfgang - - 2012
Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or aging. Cognition refers to a capacity for information processing, applying knowledge, and changing preferences. It involves memory, attention, executive functions, perception, language, and psychomotor functions. The term nootropics ...
Weyker Paul D - - 2012
Lung ischemia reperfusion injury (LIRI) is a pathologic process occurring when oxygen supply to the lung has been compromised followed by a period of reperfusion. The disruption of oxygen supply can occur either via limited blood flow or decreased ventilation termed anoxic ischemia and ventilated ischemia, respectively. When reperfusion occurs, ...
Connes Philippe - - 2012
The present review focuses on the past and recent knowledge in the field of exercise hemorheology and presents some unresolved issues for opening discussion. Acute exercise is associated with a rise in hematocrit which results in an increase in blood viscosity. Whereas increased blood viscosity was previously viewed as having ...
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