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Elliott Simon P - - 2013
5-(2-Aminopropyl)indole (5-IT) and 3-(2-aminopropyl)indole (α-methyltryptamine, AMT) are isomeric substances and their differentiation can be a challenge under routine analytical conditions, especially when reference material is unavailable. 5-IT represents a very recent addition to the battery of new psychoactive substances that are commercially available from online retailers. This report illustrates how ...
Pusztaszeri Marc P - - 2012
BACKGROUND: In contrast to other primary thyroid neoplasms and benign thyroid tissue, it has been demonstrated histologically that dendritic cells (DCs) are associated with papillary thyroid carcinoma (PTC). However, the presence and potential diagnostic value of DCs in thyroid fine-needle aspirations (FNAs) have not been previously described. METHODS: The authors ...
Lee Sook-Kyung SK Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, - - 2012
HIV-1 has been the target of intensive research at the molecular and biochemical levels for >25 years. Collectively, this work has led to a detailed understanding of viral replication and the development of 24 approved drugs that have five different targets on various viral proteins and one cellular target (CCR5). ...
Xiao Jianwei - - 2012
The biogenesis and assembly of photosynthetic multisubunit protein complexes is assisted by a series of nucleus-encoded auxiliary protein factors. In this study, we characterize the dac mutant of Arabidopsis (Arabidopsis thaliana), which shows a severe defect in the accumulation of the cytochrome b(6)/f complex, and provide evidence suggesting that the ...
Platero Ana Isabel - - 2012
The atzS-atzT-atzU-atzV-atzW gene cluster of the Pseudomonas sp. strain ADP atrazine-degradative plasmid pADP-1, which carries genes for an outer membrane protein and the components of a putative ABC-type solute transporter, is located downstream from atzR, which encodes the LysR-type transcriptional regulator of the cyanuric acid-degradative operon atzDEF. Here we describe ...
Johnson David L - - 2012
BACKGROUND: The potential risks associated with "toilet plume" aerosols produced by flush toilets is a subject of continuing study. This review examines the evidence regarding toilet plume bioaerosol generation and infectious disease transmission. METHODS: The peer-reviewed scientific literature was searched to identify articles related to aerosol production during toilet flushing, ...
Shiels Meredith S - - 2012
The risk of anal cancer is substantially increased in HIV-infected individuals. Thus, the HIV epidemic may have influenced the increasing anal cancer trends in the United States. We estimated the impact of the HIV epidemic on trends in anal cancer incidence in the United States during 1980-2005. Data on anal ...
Zeisel Steven H SH University of North Carolina at Chapel Hill, Kannapolis, North Carolina, USA. - - 2013
The American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) Research Workshop, "Using Nutrigenomics and Metabolomics in Clinical Nutrition Research," was held on January 21, 2012, in Orlando, Florida. The conference brought together experts in human nutrition who use nutrigenomic and metabolomic methods to better understand metabolic individuality and nutrition effects ...
Mirkin S - - 2012
Objectives Bazedoxifene/conjugated estrogens (BZA/CE) has demonstrated efficacy in improving vasomotor and vulvar/vaginal atrophy symptoms in postmenopausal women. This study evaluated the endometrial safety of BZA/CE and effects on bone mineral density (BMD) compared with CE/medroxyprogesterone acetate (MPA) and placebo. Methods The Selective estrogens, Menopause, And Response to Therapy (SMART)-4 trial ...
Justa N N Clinic of Small Animal Medicine, LMU University of Munich, - - 2012
(R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine (PMPDAP) is active against feline immunodeficiency virus (FIV) in vitro, and is less toxic than other acyclic nucleoside phosphonates. Its efficacy in naturally infected cats has not been evaluated in large controlled studies. PMPDAP is effective in naturally FIV-infected cats with minimal adverse effects. Forty-five privately owned cats naturally ...
Haase Jana K - - 2012
According to pulsed-field gel electrophoresis (PFGE) typing, 4,12:a:- Salmonella enterica isolates from harbor porpoises are highly diverse. However, porpoise isolates belong to only two multilocus sequence types within the eBurst group 18 (eBG18) genetic cluster, which also includes S. enterica serovars Bispebjerg and Abortusequi. Isolates of other, serologically similar serovars ...
Granger E M - - 2012
Transforming science learning through student-centered instruction that engages students in a variety of scientific practices is central to national science-teaching reform efforts. Our study employed a large-scale, randomized-cluster experimental design to compare the effects of student-centered and teacher-centered approaches on elementary school students' understanding of space-science concepts. Data included measures ...
Focsan Alexandrina Ligia - - 2012
The radical intermediates of the n-octanoic monoester and n-octanoic diester of astaxanthin were detected by pulsed EPR measurements carried out on the UV-produced radicals on silica-alumina artificial matrix and characterized by Density Functional Theory (DFT) calculations. Previous Mims ENDOR for astaxanthin detected the radical cation and neutral radicals formed by ...
Morandi Alessandro A Department of Rehabilitation and Aged Care, Hospital Ancelle, Cremona, Italy. - - 2012
To identify valid tools to diagnose delirium superimposed on dementia. Systematic review of studies of delirium tools that explicitly included individuals with dementia. Hospital. Studies were included if delirium assessment tools were validated against standard criteria, and the presence of dementia was assessed according to standard criteria that used validated ...
Hausmann Ralf - - 2012
P2X receptors are trimeric ATP-gated cation channels involved in fast signal transduction in many cell types. In this study, we used homology modeling of the rat P2X2 receptor with the zebrafish P2X4 X-ray template to determine that the side chains of the Glu167 and Arg290 residues are in close spatial ...
Cossins L - - 2012
Complex regional pain syndrome (CRPS) is a disabling pain condition with sensory, motor and autonomic manifestations. Uncertainty remains about how CRPS can be effectively managed. We conducted a systematic review of randomized controlled trials (RCTs) for treatment and prophylactic interventions for CRPS published during the period 2000-2012, building on previous ...
Prey S - - 2012
Background  Imatinib mesylate is a potent inhibitor of platelet-derived growth factor and transforming growth factor-β signalling pathways which may play a role in systemic sclerosis (SSc)-associated skin changes. Objectives  We aimed primarily at assessing the efficacy of imatinib mesylate in scleroderma skin fibrosis. Methods  We performed a phase II double-blinded ...
Matsuda Ryosuke - - 2012
Object Maximal resection of symptomatic cavernous angioma (CA), including its surrounding gliosis if possible, has been recommended to minimize the risk of seizures or (re)bleeding. However, despite recent neurosurgical advances, such extensive CA removal is still a challenge in eloquent areas. The authors report a consecutive series of patients who ...
Sviridov Denis O DO National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, MD 20892, - - 2013
The bihelical apolipoprotein mimetic peptide 5A effluxes cholesterol from cells and reduces inflammation and atherosclerosis in animal models. We investigated how hydrophobic residues in the hinge region between the two helices are important in the structure and function of this peptide. By simulated annealing analysis and molecular dynamics modeling, two ...
Wong Janice C - - 2012
Cockayne syndrome (CS) (MIM 133540, 216400) is an autosomal recessive syndrome that features growth failure, neurological dysfunction, premature aging and dementia [1]. Many CS cases are associated with mutations in the gene that encodes for Cockayne syndrome B (CSB), which functions in DNA repair [2]. Mice deficient in CSB exhibit ...
Hebling Christine M - - 2012
Peanuts (Arachis hypogaea) are the cause of one of the most prevalent food allergies worldwide. Thermal processing (e.g. roasting) of peanuts and peanut-containing foods results in complex chemical reactions that alter structural conformations of peanut proteins, preventing accurate detection of allergens by most immunochemical and targeted screening methodologies. To improve ...
Stoops M A - - 2012
The objective was to identify suitable enzyme immunoassays to monitor gonadal and placental function in the female polar bear. Immunoreactive progesterone, progesterone metabolite (PdG), estrogen, and androgen metabolite (T) concentrations were measured in fecal samples collected over 24 mo from captive female bears (N = 20). Whereas fecal extracts produced ...
Munusamy Vani - - 2012
Selective blockade of the serotonin 5-HT(2A) receptor is a useful therapeutic approach for a number of disorders, including schizophrenia, insomnia and ischemic heart disease. A series of aporphines was docked into a homology model of the rat 5-HT(2A) receptor using AutoDock. Selected compounds with high in silico binding affinities were ...
Troy Andrew A Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, - - 2012
In response to muscle injury, satellite cells activate the p38α/β MAPK pathway to exit quiescence, then proliferate, repair skeletal muscle, and self-renew, replenishing the quiescent satellite cell pool. Although satellite cells are capable of asymmetric division, the mechanisms regulating satellite cell self-renewal are not understood. We found that satellite cells, once ...
Chang J C - - 2012
After nucleation, a large earthquake propagates as an expanding rupture front along a fault. This front activates countless fault patches that slip by consuming energy stored in Earth's crust. We simulated the slip of a fault patch by rapidly loading an experimental fault with energy stored in a spinning flywheel. ...
Reck Christiane - - 2012
The use of multiple trajectories microelectrode recording (MER) during implantation of deep brain stimulation (DBS) electrodes into the subthalamic nucleus (STN) in patients with Parkinson's disease (PD) is discussed controversially because of possible risks and unclear benefits. The aim of the study is to investigate whether MER combined with intraoperative ...
Salzillo Tommaso - - 2012
The photochemical reaction of 9,10-dinitroanthracene (DNO2A) to anthraquinone (AQ) + 2NO has been studied by means of lattice phonon Raman spectroscopy in the spectral region 10-150 cm-1. In fact, crystal to crystal transformations are best revealed by following changes in the lattice modes, as even small modifications in the crystal ...
Stork Simone - - 2012
Protein import into complex plastids of red algal origin is a multistep process including translocons of different evolutionary origins. The symbiont-derived ERAD-like machinery (SELMA), shown to be of red algal origin, is proposed to be the transport system for preprotein import across the periplastidal membrane of heterokontophytes, haptophytes, cryptophytes, and ...
Hu Bin - - 2012
A rigid trans pyridine-4-thiol coordinated dinuclear zinc(ii) macrocyclic complex trans-[Zn(2)L(py-4-SH)(2)](ClO(4))(2) () is introduced for the first time to fabricate self-assembled nanocomposite films with gold nanoparticles (Au-NPs) covering 1 μm gap gold electrodes. Utilizing the same self-assembled fabrication technique but different concentrations of dithiol and Au-NPs in chloroform, a series of ...
Killian Peter H - - 2012
In America and Western Europe prostate cancer is the second leading cause of death in men. Emerging evidence suggests that chronic inflammation is a major risk factor for the development and metastatic progression of prostate cancer.We previously reported that the chemopreventive polyphenol Curcumin inhibits the expression of the pro-inflammatory cytokines ...
Holden Patricia A - - 2012
Research into the health and environmental safety of nanotechnology has seriouslylagged behind its emergence in industry. While humans have often adopted synthetic chemicals without considering ancillary consequences, the lessons learned from worldwide pollution should motivate making nanotechnology compatible with environmental concerns. Researchers and policymakers need to understand exposure and harm ...
McKinley Andrew W - - 2012
The bi-exponential emission decay of [Ru(L)(2) dppz](2+) (L=N,N'-diimine ligand) bound to DNA has been studied as a function of polynucleotide sequence, enantiomer, and nature of L (phenanthroline vs. bipyridine). The lifetimes (τ(i) ) and pre-exponential factors (α(i) ) depend on all three parameters. With [poly(dA-dT)](2) , the variation of α(i) ...
McHugh Brian J - - 2012
The etiology of os odontoideum has been debated in the literature since the condition was initially described. The authors present the case of a 4-year-old girl who was found to have an os odontoideum with atlantoaxial instability after a motor vehicle collision. Imaging performed 3 years earlier demonstrated an incompletely ...
Athe Sudhakar - - 2012
This paper describes the formal total synthesis of (+)-Neopeltolide, a cytotoxic macrolide isolated from the marine sponge Neopeltidae. The key features of the synthesis include an asymmetric Evans alkylation to fix the C9-methyl center, Jacobsen hydrolytic kinetic resolution of terminal epoxides followed by their regioselective opening to fix the stereocenters ...
Apland James P JP US Army Medical Research Institute of Chemical Defense, Neurobehavioral Toxicology Branch, Aberdeen Proving Ground, Maryland, - - 2013
Control of brain seizures after exposure to nerve agents is imperative for the prevention of brain damage and death. Animal models of nerve agent exposure make use of pretreatments, or medication administered within 1 minute after exposure, in order to prevent rapid death from peripheral toxic effects and respiratory failure, ...
Kumar Rajeev - - 2012
Dilute acid as well as water only (hydrothermal) pretreatments often lead to a significant hemicellulose loss to soluble furans and insoluble degradation products, collectively termed as chars and/or pseudo-lignin. In order to understand the factors contributing to reducing sugar yields from pretreated biomass and the possible influence of hemicellulose derived ...
Barcan Gregg A - - 2012
A highly torquoselective thermal triene 6π electrocyclization controls the relative stereochemistry between the C3 and C18 stereocenters of the dodecahydroindolo[2,3-a]benzo[g]quinolizine skeleton of reserpine-type alkaloids. Employing a tandem cross-coupling/electrocyclization protocol allowed us to form the requisite triene and ensure its subsequent cyclization. A novel low-temperature dibromoketene acetal Claisen rearrangement established the ...
Gjersing Erica - - 2012
Large populations of potential cellulosic biomass feedstocks are currently being screened for fuel and chemical applications. The monomeric sugar content, released through hydrolysis, is of particular importance and is currently measured with time-consuming HPLC methods. A method for sugar detection is presented here that employs (1) H NMR spectra regressed ...
Sauzet Odile - - 2012
BACKGROUND:: Evidence from randomized controlled trials is regarded as the gold standard in clinical research and yet the quality of the conduct and reporting of trials is variable, even post-Consolidated Standards of Reporting Trials. This study arose from a systematic review and cost-effectiveness analysis of treatment for neuropathic pain. The ...
Belyusar Daniel D The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center, Departments of Pediatrics and Neuroscience, Albert Einstein College of Medicine, Van Etten Building - Wing 1C, 1225 Morris Park Avenue, Bronx, NY 10461, - - 2013
Neuroimaging has demonstrated anatomical overlap between covert and overt attention systems, although behavioral and electrophysiological studies have suggested that the two systems do not rely on entirely identical circuits or mechanisms. In a parallel line of research, topographically-specific modulations of alpha-band power (~8-14 Hz) have been consistently correlated with anticipatory ...
Almeida-Paes Rodrigo - - 2012
Sporothrix schenckii is the etiological agent of sporotrichosis, the main subcutaneous mycosis in Latin America. Melanin is an important virulence factor of S. schenckii, which produces dihydroxynaphthalene melanin (DHN-melanin) in conidia and yeast cells. Additionally, l-dihydroxyphenylalanine (l-DOPA) can be used to enhance melanin production on these structures as well as ...
Messerlian Carmen - - 2013
Do women who conceive without treatment after a long time to pregnancy (TTP) have an increased risk of preterm birth compared with women in the general obstetric population? Based on this meta-analyses of 14 studies, women with a long TTP are at an increased risk of preterm birth: pooled crude ...
Huang Ya-Chi YC Institute of Medical Science, University of Toronto, Toronto, Ontario, - - 2013
Early-stage type 1 diabetes (T1D) exhibits hyperglucagonemia by undefined cellular mechanisms. Here we characterized α-cell voltage-gated ion channels in a streptozotocin (STZ)-induced diabetes model that lead to increased glucagon secretion mimicking T1D. GYY mice expressing enhanced yellow fluorescence protein in α cells were used to identify α cells within pancreas ...
Evans Michael J - - 2012
As parallel advances in cancer biology and drug development continue to elevate the role of targeted therapies in oncology, the need for imaging biomarkers that systematically measure the biology associated with therapeutic intervention has become more urgent. Although the molecular imaging community has a commitment to develop technologies to this ...
Vicente-Grabovetsky Alejandro - - 2012
Human visual cortex shows retinotopic organization during both perception and attention, but whether this remains true for visual short-term memory (VSTM) is uncertain. In 2 functional magnetic resonance imaging experiments, we separated retinotopic activation during perception, attention, and VSTM maintenance. The 2 experiments differed in whether spatial encoding of the ...
Le Grice Stuart F J SF RT Biochemistry Section, HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA. - - 2012
Synthesis of integration-competent, double-stranded DNA from the (+)-RNA strand genome of retroviruses and long terminal repeat-containing retrotransposons reflects a multistep process catalyzed by the virus-encoded reverse transcriptase (RT). In conjunction with RNA- and DNA-templated DNA synthesis, a hydrolytic activity of the same enzyme (RNase H) is required to remove genomic ...
Goto Tatenobu - - 2012
Background:Oxidative stress (oxidant/antioxidant imbalance) plays an important role in the pathophysiolog of neonatal sepsis. The present study evaluated whither an antisense peptide endothelin receptor antagonist ETR-P1/fl could attenuate oxidative stress in a neonatal sepsis model.Methods:Eighteen 3-day-old piglets were anesthetized and mechanically ventilated. Six piglets received cecal ligation and perforation (CLP) ...
Kumari Namita - - 2012
A new bis-indolyl-based colorimetric probe has been synthesized. This allows a Michael-type adduct formation for the detection of cyanide ions. The probe shows a remarkable color change from red to colorless upon addition of the cyanide ions in pure water. The cyanide ion reacts with the probe and removes the ...
Gupta Sunil Kumar SK Department of Neurosurgery, Postgraduate Institute for Medical Education and Research, Chandigarh, India. - - 2012
Excision of petroclival meningiomas remains a surgical challenge. Extradural anterior petrosectomy is widely used as a skull base approach for these tumors; however, this approach has significant procedure-related morbidity. The authors describe an alternative technique of tailored intradural petrosectomy for removal of petroclival meningiomas. This technique was used successfully in ...
Cassiman Catherine - - 2012
Enhanced S-cone syndrome is a rare, slowly progressive autosomal recessively inherited retinal degeneration related to mutations in the NR2E3 gene. Patients often present with night blindness, visual loss and visual field abnormalities. Patients with enhanced S-cone syndrome exhibit a variable clinical phenotype associated with various degrees of pigmentary changes and ...
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