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Results 601 - 650 of 3450
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Ponticelli Claudio - - 2012
A large number of factors can influence the clinical outcome of kidney transplant recipients, but the active role of the patient to prevent the possible complications related to transplant and its treatment is often neglected. Poor adherence to prescriptions is frequent in transplant recipients and represents a major contributor to ...
Wolf Patrick S - - 2013
Patients undergoing liver resection for colorectal cancer liver metastasis (CRCLM) are often treated with chemotherapy before surgery. However, the associations between chemotherapy, liver injury, perioperative outcomes, and other confounding factors remain unclear. This study investigates the effect of preoperative chemotherapy for CRCLM on nontumoral liver histology and perioperative outcomes in ...
Jozkowski Kristen N - - 2012
Sexual assault continues to be a salient health concern, especially among college women. Because assault is often defined in terms of consent, prevention efforts hinge on promoting the definition and the obtainment of consent as a mechanism to reduce assault. Despite the focus on consent promotion, research specifically examining consent ...
Mack Julia - - 2012
A novel magnetically actuated scaffold was used to explore the effects of strain stimulus on the proliferation and spatial distribution of smooth muscle cells and improve cell viability in the scaffold interior by pumping nutrients throughout the structure. Magnetically actuable scaffolds were fabricated in a tube shape by winding electrospun ...
Berton Olivier O Department of Psychiatry, Center for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, PA 19104, USA. - - 2012
Advances in characterizing the neuropathology and functional dysconnectivity of depression and promising trials with emerging circuit-targeted and fast-onset therapeutics are providing unprecedented opportunities to gain deeper insight into the neurobiology of this devastating and pervasive disorder. Because of practical and ethical limitations to dissecting these mechanisms in humans, continued progress ...
Yordy Brian B Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, - - 2013
Autophagy is an evolutionarily ancient process eukaryotic cells utilize to remove and recycle intracellular material in order to maintain cellular homeostasis. In metazoans, the autophagy machinery not only functions in this capacity but also has evolved to perform a diverse repertoire of intracellular transport and regulatory functions. In response to ...
Walden Andrew P - - 2012
Despite 50-60% of intensive care patients demonstrating evidence of pleural effusions there has been little emphasis placed on the role of effusions in the aetiology of weaning failure. Critical illness and mechanical ventilation lead to multiple perturbations of the normal physiological processes regulating pleural fluid homeostasis and consequently failure of ...
Alemu Endalkachew Ashenafi EA Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, - - 2012
Autophagy is a lysosome-dependent degradation system conserved among eukaryotes. The mammalian Atg1 homologues, Unc-51 like kinase (ULK) 1 and 2, are multifunctional proteins with roles in autophagy, neurite outgrowth, and vesicle transport. The mammalian ULK complex involved in autophagy consists of ULK1, ULK2, ATG13, FIP200, and ATG101. We have used ...
Chen Hui - - 2012
The ultraweak chemiluminescence (CL) from the reaction of hydrogen peroxide and carbonate is strongly enhanced by the branched NaYF(4):Yb(3+)/Er(3+) nanoparticle (NP) in the presence of aqueous ammonia. It was explained that ammonia catalyzes the decomposition of peroxymonocarbonate, which is the product of hydrogen peroxide mixing with bicarbonate, making the formation ...
Yang Jae Jeong - - 2012
SCOPE: To investigate whether genes involved in AKT/nuclear factor kappa B signaling and/or gene-environment interactions between the genes and phytoestrogens may be susceptible factors for gastric cancer. METHODS AND RESULTS: The representative single nucleotide polymorphisms (SNPs) identified during the primary analysis (screening a total of 622 SNPs within ± 5 ...
Yin Decui - - 2012
A new aerobic, motile, moderately thermophilic, rod-shaped bacterium, strain CLWT, was isolated from a terrestrial hot spring of a garden exposition, located in Xiamen City, Fujian Province, the People's Republic of China. Strain CLWT grew as equally beige dry colonies on solid 2216E medium and formed flocks in fluid medium. ...
Ilodigwe Don D Division of Neurosurgery, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Ontario, - - 2013
In randomized clinical trials of subarachnoid hemorrhage (SAH) in which the primary clinical outcomes are ordinal, it has been common practice to dichotomize the ordinal outcome scale into favorable versus unfavorable outcome. Using this strategy may increase sample sizes by reducing statistical power. Authors of the present study used SAH ...
Ooi Carmen C-W - - 2012
One reason why specific language impairment (SLI) is grossly under-identified in Malaysia is the absence of locally- developed norm-referenced language assessment tools for its multilingual and multicultural population. Spontaneous language samples provide quantitative information for language assessment, and useful descriptive information on child language development in complex language and cultural ...
Pressiani T - - 2012
BackgroundSorafenib has shown survival benefits in patients with advanced hepatocellular carcinoma (HCC) and Child-Pugh (CP) class A liver function. There are few prospective data on sorafenib in patients with HCC and CP class B.Patients and methodsA consecutive prospective series of 300 patients with CP class A or B HCC were ...
Fromer Menachem - - 2012
Sequencing of gene-coding regions (the exome) is increasingly used for studying human disease, for which copy-number variants (CNVs) are a critical genetic component. However, detecting copy number from exome sequencing is challenging because of the noncontiguous nature of the captured exons. This is compounded by the complex relationship between read ...
Furst D E - - 2012
Objective: The objective of this paper is to determine the incidence and prevalence of adult systemic lupus erythematosus (SLE) in a large US managed-care population.Methods: Subject inclusion in the incidence cohort required a medical claim with an SLE diagnosis and a service date from 2003 to 2008 that satisfied the ...
Traylor Matthew M Stroke and Dementia Research Centre, St George's University of London, London, - - 2012
Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of ...
Drielsma Anais - - 2012
BACKGROUND: Human congenital non-syndromic hydrocephalus is a vastly heterogeneous condition. A subgroup of cases are not secondary to a specific cause (eg, a neural tube defect), and within this subgroup, autosomal recessive inheritance has been described. One homozygous mutation in the DAPLE (Dvl-associating protein with a high frequency of leucine ...
Huang Chung-Hao CH Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, - - 2013
In 2008, the Dengue NS1 Ag STRIP (Bio-Rad Laboratories, Marnes-la-Coquette, France) was introduced to routine dengue diagnostics in Taiwan, in addition to real-time reverse-transcription polymerase chain reaction (PCR), virus isolation, and capture immunoglobulin (Ig)M/IgG enzyme-linked immunosorbent assay (ELISA). This study aimed to evaluate the benefit of this assay and factors ...
McCormick Susan P - - 2012
Trichothecenes are sesquiterpenoid toxins produced by Fusarium species. Since these mycotoxins are very stable, there is interest in microbial transformations that can remove toxins from contaminated grain or cereal products. Twenty-three yeast species assigned to the Trichomonascus clade (Saccharomycotina, Ascomycota), including four Trichomonascus species and 19 anamorphic species presently classified ...
Paranjpye Rohinee - - 2012
Since 1997, cases of Vibrio parahaemolyticus-related gastroenteritis from the consumption of raw oysters harvested in Washington State have been higher than historical levels. These cases have shown little or no correlation with concentrations of potentially pathogenic V. parahaemolyticus (positive for the thermostable direct hemolysin gene, tdh) in oysters, although significant ...
Holzmann David - - 2012
Background The impact of transnasal endoscopic approaches to the central skull is still increasing. Its use in small children (i.e., under the age of 5 years) is of questionable value.Patients and Methods The present study is a description of a series of five children under the age of 5 years with lesions ...
Katakami Naoto N Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Japan. - - 2012
The aim of this study is to evaluate whether noninvasive ultrasonic tissue characterization of carotid plaque using integrated backscatter (IBS) analysis can be a predictor of future cardiovascular events (CVE) in asymptomatic type 2 diabetic patients. We prospectively evaluated the association between Calibrated-IBS value, an ultrasonic marker for tissue characteristics ...
Aronson Paul L - - 2012
  There is concern that the use of topical corticosteroids in patients with eczema herpeticum may facilitate dissemination of herpes simplex virus and worsen disease. Our primary aim therefore was to determine whether topical corticosteroid use in children hospitalized with eczema herpeticum is associated with longer hospital length of stay ...
Horng Chi-Ting - - 2013
To evaluate the activity of lowering intraocular pressure (IOP) by Cassiae seed in the DBA/2J mouse glaucoma model. Young male (mean age: 3 months) inherited glaucoma mice (BDA/2J) were enrolled in this study. To evaluate the potential of Cassiae seed in the treatment of glaucoma, all subjects were divided into ...
Durante Federica - - 2012
Income inequality undermines societies: The more inequality, the more health problems, social tensions, and the lower social mobility, trust, life expectancy. Given people's tendency to legitimate existing social arrangements, the stereotype content model (SCM) argues that ambivalence-perceiving many groups as either warm or competent, but not both-may help maintain socio-economic ...
J Armstrong P C - - 2012
Systemic Staphylococcus (S.) aureus infections are associated with disseminated intravascular coagulation (DIC), a disorder characterised by simultaneous thrombosis and bleeding, which ultimately leads to multiple organ failure and thrombocytopenia [1]. S. aureus secretes pathogenic proteins including the Staphylococcal superantigen-like proteins (SSLs); a protein family structurally homologous to the superantigens (SAg). ...
Lin Ta-Hui - - 2012
HtpX is an integral cytoplasmic membrane metalloprotease well conserved in numerous bacteria. A recent study showed that expression of the Bacillus subtilis htpX gene is under dual negative control by Rok and a novel type of transcriptional regulator, YkrK. Here we report that expression of the B. subtilis htpX gene ...
Nooka A K - - 2012
BackgroundBecause follicular lymphoma (FL) patients have heterogeneous outcomes, the FL international prognostic index (FLIPI) was developed to risk-stratify patients and to predict survival. However, limited data exist regarding the role of FLIPI in the era of routine first-line rituximab (R) and R-chemotherapy regimens and in the setting of community oncology ...
Wallis Robert S - - 2012
Six new anti-tuberculosis compounds in 4 classes are presently in clinical trials. Although these show substantial promise for drug-resistant (DR) tuberculosis, the presently planned studies of these compounds will not inform their optimal use, as each will be tested singly vs. placebo with existing drugs, rather than in new regimens. ...
Alderman Sarah L - - 2012
The type 2 11β-hydroxysteroid dehydrogenase (11βHSD2) converts active glucocorticoids to their inactive derivatives (ex. cortisol to cortisone). In most vertebrates, 11βHSD2 is essential for conferring aldosterone-specific actions in mineralocorticoid target tissues and for protecting glucocorticoid-sensitive tissues during stress. However, teleosts do not synthesize aldosterone, and the function of 11βHSD2 is ...
Ragab Marwa A A - - 2012
A simple, precise, accurate and robust high-performance liquid chromatography assay was developed and validated for the simultaneous analysis of metoclopramide and paracetamol in human urine. The drugs were isolated from urine samples by solid-phase extraction using C8 cartridges, then analyzed on a C18 reversed-phase column using a mixture of aqueous ...
Vanden Hoek A L - - 2012
Factor Xa (FXa) is a critical blood coagulation enzyme that is activated by proteolysis from its precursor factor X (FX) [1]. The generation of FXa is initiated by tissue factor (TF)/factor VIIa (FVIIa)-dependent extrinsic tenase complex and then amplified by factor VIIIa (FVIIIa)/factor IXa (FIXa)-dependent intrinsic tenase complex. Thus, FX ...
Gustafsson Sheppard Nina - - 2012
Estrogen receptor-α (ERα) is initially overexpressed in two-thirds of all breast cancer and is involved in its development and proliferation. We previously reported that the RBCC protein interacting with PKC 1 (RBCK1) interacts with the ERα promoter and that RBCK1 expression positively correlates with ERα levels, expression of ERα downstream ...
Lamani Manjunath - - 2012
Single-step amination: The N-iodosuccinimide (NIS)-catalyzed amidation of acetophenone derivatives by using tert-butylhydroperoxide (TBHP) as an oxidant is presented. A variety of acetyl derivatives of heterocyclic compounds were easily converted to their corresponding ketoamides under these conditions. A new, NIS-catalyzed amination of propiophenone and its derivatives in the presence of TBHP ...
Froestl Wolfgang - - 2012
Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or aging. Cognition refers to a capacity for information processing, applying knowledge, and changing preferences. It involves memory, attention, executive functions, perception, language, and psychomotor functions. The term nootropics ...
Weyker Paul D - - 2012
Lung ischemia reperfusion injury (LIRI) is a pathologic process occurring when oxygen supply to the lung has been compromised followed by a period of reperfusion. The disruption of oxygen supply can occur either via limited blood flow or decreased ventilation termed anoxic ischemia and ventilated ischemia, respectively. When reperfusion occurs, ...
Muñoz-Provencio Diego - - 2012
Sortases are a class of enzymes that anchor surface proteins to the cell wall of Gram-positive bacteria. Lactobacillus casei BL23 harbors four sortase genes, two belonging to class A (srtA1 and srtA2) and two belonging to class C (srtC1 and srtC2). Class C sortases were clustered with genes encoding their ...
Rosenfield Robert L RL University of Chicago Medical Center, Section of Adult and Pediatric Endocrinology, Metabolism, and Diabetes, 5841 South Maryland Avenue (MC-5053), Chicago, Illinois 60637, USA. - - 2012
The magnitude of sleep-related gonadotropin rise required to activate pubertal gonadal function is not established. Our objective was to determine the normal relationship between sleep-related pubertal hormone levels and pituitary-testicular responsiveness to a GnRH agonist (GnRHag) test across the pubertal transition. DESIGN/SETTING AND PARTICIPANTS: We conducted a prospective study in ...
Kimura Hiroshi - - 2012
Noncatalytic hydrothermolyses of malto- and cello-oligosaccharides (di-, tri-, tetraose), linked by α- and β-1,4-glycosidic bonds, respectively, were investigated at 100-140 °C. In situ (13)C NMR spectroscopy was applied to elucidate the position and pathways of the glycosidic bond breakage and the dependence of the hydrolysis rate on the bond type. ...
Harris Reuben S RS Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota 55455, USA. - - 2012
Cellular proteins called "restriction factors" can serve as powerful blockades to HIV replication, but the virus possesses elaborate strategies to circumvent these barriers. First, we discuss general hallmarks of a restriction factor. Second, we review how the viral Vif protein protects the viral genome from lethal levels of cDNA deamination ...
Krini Maro - - 2012
Background:Celiac disease (CD) has been associated with HLA class II heterodimers. This study aimed at determining the HLA genotypic and allelic distribution in Greek children with CD compared to the general population.Methods:118 children with CD and 120 healthy individuals serving as controls were included in the study.Results:Higher frequencies for HLA ...
Kedem Moran Hausman - - 2012
Abstract Background: Little is known about the effect of maternal age on human milk (HM) composition. This study was designed to study fat content, estimated by creamatocrit (CMT), in HM collected in the first 2 weeks of life in older (≥35 years) compared with younger (<35 years) mothers. Study Design ...
Mao Jianwen - - 2012
Tamoxifen is a triphenylethylene non-steroidal antiestrogen anticancer agent. It also shows inhibitory effects on metastasis of estrogen receptor (EsR)-independent tumors, but the underlying mechanism is unclear. It was demonstrated in this study that, in EsR-negative and highly metastatic human hepatocellular carcinoma MHCC97H cells, tamoxifen inhibited cell migration, volume-activated Cl(-) currents ...
Stasch Andreas - - 2012
The new sterically demanding aminoiminophosphorane Ph(2) P(ļ£¾NDip)(NHDip) (Dip=C(6) H(3) -2,6-iPr(2) ; LH, 1) has been prepared as a precursor to the potassium complex [LK] (2) and a series of heteroleptic zinc(II) complexes, namely [(LZnBr)(2) ] (3), [LZnMe] (4), [LZnEt] (5), and [(LZnI)(2) ] (6). The products have been obtained either ...
Epa Vidana Chandana - - 2012
Products are increasingly incorporating nanomaterials, but we have a poor understanding of their adverse effects. To assess risk, regulatory authorities need more experimental testing of nanoparticles. Computational models play a complementary role in allowing rapid prediction of potential toxicities of new and modified nanomaterials. We generated quantitative, predictive models of ...
Kim Ggotpin - - 2012
Elevated homocysteine (Hcy) levels have been associated with an increased risk of cognitive impairment and Alzheimer's disease (AD). Tissue factor pathway inhibitor (TFPI) has recently emerged as a candidate marker of endothelial damage in AD. We investigated the relationship between plasma levels of folate, vitamin B12, Hcy, and TFPI, as ...
McCarthy Alex J - - 2012
Staphylococcus aureus clonal complex 398 (CC398) isolates colonize livestock and can spread to human contacts. Genetic analysis of isolates epidemiologically associated with human-to-human, but not livestock, transmission in multiple countries and continents identified a common clade that was negative for tet(M) and positive for bacteriophage 3. Another group of human-to-human-transmitted ...
Fitch Simon R SR Department of Haematology, Cambridge Institute for Medical Research, Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 0XY, - - 2012
The first adult-repopulating hematopoietic stem cells (HSCs) emerge in the aorta-gonads-mesonephros (AGM) region of the embryo. We have recently identified the transcription factor Gata3 as being upregulated in this tissue specifically at the time of HSC emergence. We now demonstrate that the production of functional and phenotypic HSCs in the ...
Sasaki Manabu - - 2012
Objective Far-out syndrome (FOS) is a rare incident caused by L5 nerve root entrapment in the far-out area, the L5-S1extraforaminal area between the transverse process and the sacral ala. The purpose of this study is to disclose the middle-term surgical outcomes of microscopic posterior decompression in the far-out area (MPDFA).Material and ...
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