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Results 601 - 650 of 3450
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Chen Hui - - 2012
The ultraweak chemiluminescence (CL) from the reaction of hydrogen peroxide and carbonate is strongly enhanced by the branched NaYF(4):Yb(3+)/Er(3+) nanoparticle (NP) in the presence of aqueous ammonia. It was explained that ammonia catalyzes the decomposition of peroxymonocarbonate, which is the product of hydrogen peroxide mixing with bicarbonate, making the formation ...
Yang Jae Jeong - - 2012
SCOPE: To investigate whether genes involved in AKT/nuclear factor kappa B signaling and/or gene-environment interactions between the genes and phytoestrogens may be susceptible factors for gastric cancer. METHODS AND RESULTS: The representative single nucleotide polymorphisms (SNPs) identified during the primary analysis (screening a total of 622 SNPs within ± 5 ...
Yin Decui - - 2012
A new aerobic, motile, moderately thermophilic, rod-shaped bacterium, strain CLWT, was isolated from a terrestrial hot spring of a garden exposition, located in Xiamen City, Fujian Province, the People's Republic of China. Strain CLWT grew as equally beige dry colonies on solid 2216E medium and formed flocks in fluid medium. ...
Ooi Carmen C-W - - 2012
One reason why specific language impairment (SLI) is grossly under-identified in Malaysia is the absence of locally- developed norm-referenced language assessment tools for its multilingual and multicultural population. Spontaneous language samples provide quantitative information for language assessment, and useful descriptive information on child language development in complex language and cultural ...
Pressiani T - - 2012
BackgroundSorafenib has shown survival benefits in patients with advanced hepatocellular carcinoma (HCC) and Child-Pugh (CP) class A liver function. There are few prospective data on sorafenib in patients with HCC and CP class B.Patients and methodsA consecutive prospective series of 300 patients with CP class A or B HCC were ...
Furst D E - - 2012
Objective: The objective of this paper is to determine the incidence and prevalence of adult systemic lupus erythematosus (SLE) in a large US managed-care population.Methods: Subject inclusion in the incidence cohort required a medical claim with an SLE diagnosis and a service date from 2003 to 2008 that satisfied the ...
Drielsma Anais - - 2012
BACKGROUND: Human congenital non-syndromic hydrocephalus is a vastly heterogeneous condition. A subgroup of cases are not secondary to a specific cause (eg, a neural tube defect), and within this subgroup, autosomal recessive inheritance has been described. One homozygous mutation in the DAPLE (Dvl-associating protein with a high frequency of leucine ...
Wu Ling - - 2012
Adipose-derived stem cells (ASCs) have been discovered for more than a decade. Due to the large numbers of cells that can be harvested with relatively little donor morbidity, they are considered to be an attractive alternative to bone marrow derived mesenchymal stem cells. Consequently, isolation and differentiation of ASCs draw ...
Huynh Cong Truc - - 2012
Novel copolymers containing both anionic and cationic pH-sensitive moieties were reported. These amphoteric copolymers exhibited special closed-loop reversible sol-gel-sol phase transitions in response to both pH and temperature.
Okamura Hirohiko - - 2012
Serine/threonine protein phosphatase 2A (PP2A) participates in regulating many important physiological processes such as cell cycle, growth, apoptosis, and signal transduction. Osterix is a zinc-finger-containing transcription factor that is essential for osteoblast differentiation and regulation of many bone-related genes. We have recently reported that decrease in α-isoform of PP2A catalytic ...
Kothny W - - 2012
AIM: Assess the efficacy and safety of vildagliptin 50 mg bid as add-on therapy to insulin in type 2 diabetes mellitus (T2DM) METHODS: Multicenter, double-blind, placebo-controlled, parallel group, clinical trial in T2DM patients inadequately controlled by stable insulin therapy, with or without metformin. Patients received treatment with vildagliptin 50 mg ...
Papale F - - 2012
Thyroid cancer is not very common, accounting for 1-2% of all cancers, with a population incidence of about 0.004%. Currently, the ability to discriminate between follicular adenoma and carcinoma represents the major challenge in preclinical diagnosis of thyroid proliferative lesions. Better discrimination between the two would help avoid unnecessary thyroidectomy ...
Vataire Anne-Lise - - 2012
Background. In breast cancer, adjuvant chemotherapy is often prescribed as a precautionary measure and sometimes unnecessarily. A diagnostic test based on estimating the risk of recurrence at 10 years for women with breast cancer in early stage has been developed (Oncotype DX(®)). Method. A Markov's model was adapted to evaluate the long-term ...
Linglart Agnès - - 2012
Context:Acrodysostosis is a rare skeletal dysplasia that is associated with multiple resistance to G protein-coupled receptor (GPCR) signaling hormones in a subset of patients. Acrodysostosis is genetically heterogeneous because it results from heterozygous mutations in PRKAR1A or PDE4D, two key actors in the GPCR-cAMP-protein kinase A pathway.Objective:Our objective was to ...
Shi Shi-Liang - - 2012
A general catalytic enantioselective method that can produce 5, 6, and 7-membered N-heterocycles possessing various ketone moieties was developed, starting from stable and easily available cyclic hemiaminals and ketones. The method involves three successive steps in one pot (aldol addition, dehydration, and enantioselective intramolecular aza-Michael reaction), all of which are ...
Brandstetter Thomas - - 2012
Abstract The aim of this article is to show how, and in which context, astrobiological reasoning was employed before the establishment of astrobiology as a scientific discipline. By way of an example, I will discuss a popular science book published in 1931 by the Hungarian journalist Desiderius Papp. The author ...
Khalighi Mohammad Mehdi - - 2012
The Bloch-Siegert (B-S) B 1+ mapping method has been shown to be fast and accurate, yet it suffers from high Specific Absorption Rate (SAR) and moderately long echo time. An adiabatic RF pulse design is introduced here for optimizing the off-resonant B-S RF pulse to achieve more B-S B 1+ measurement sensitivity ...
Gumert Michael D - - 2012
Long-tailed macaques (Macaca fascicularis) feed opportunistically in many habitats. The Burmese subspecies (M. f. aurea) inhabits coastal areas in southwestern Thailand and Myanmar, and some of their populations have adapted lithic customs for processing encased foods in intertidal habitats. We investigated the diet of such macaques in Laemson National Park, ...
Al-Makoshi Amel - - 2012
Abstract Background: Saudi Arabia has a declining rate of breastfeeding and increasing levels of childhood asthma and atopic disease. In highly economically developed countries, breastfeeding of children at high risk of atopic disease reduces the likelihood of atopic dermatitis, wheezing associated with respiratory infections, and possibly asthma. This study investigated ...
Machyna Martin - - 2012
The cell nucleus contains dozens of subcompartments that separate biochemical processes into confined spaces. Cajal bodies (CBs) were discovered more than 100 years ago, but only extensive research in the past decades revealed the surprising complexity of molecular and cellular functions taking place in these structures. Many protein and RNA ...
Terao Ken - - 2012
Eight amylose tris(ethylcarbamate) (ATEC) samples ranging in the weight-average molar mass M(w) from 1.0 × 10(4) to 1.1 × 10(6) g mol(-1) and five amylose tris(n-hexylcarbamate) (ATHC) samples of which M(w) varies from 4.9 × 10(4) to 2.2 × 10(6) g mol(-1) have been prepared from enzymatically synthesized amylose samples ...
Yadav J S - - 2012
A highly stereoselective total synthesis of (-)-tirandamycin C has been developed following a desymmetrization protocol developed in our group, Horner-Wadsworth-Emmons olefination, acid-catalyzed ketalization, Still-Gennari (Z)-selective olefination, and Dieckmann cyclization as key reactions.
Li Yan - - 2012
A new synthetic method toward ethylene-annulated di(perylene diimides) from easily available ethylene-annulated di(perylene esters), which is conducted by ICl-induced cyclization and Mizoroki-Heck coupling of ethynylene-linked di(perylene esters), is reported.
Ordóñez Nelson G - - 2012
Signet-ring cell mesothelioma is uncommon and only two case reports have been published on this mesothelioma variant, both of which were initially misdiagnosed as signet-ring cell carcinoma. Herein are reported 23 signet-ring cell mesotheliomas that were investigated by immunohistochemistry, 12 of which were also studied by electron microscopy. Twenty-one of ...
Pietra Francesca - - 2012
We study the self-assembly of colloidal CdSe/CdS nanorods (NRs) at the liquid/air interface combining time-resolved in-situ GISAXS and ex-situ TEM. Our study shows that NR superstructure formation occurs at the liquid/air interface. Short NRs self-assemble into μm long tracks of NRs lying side by side flat on the surface. In ...
Bruner Emiliano - - 2012
Taxonomy is caught between the search for the "perfect" theory and an elusive biological variability. The lack of major advances in issues related to how "species" and other taxonomic categories are defined suggests that perhaps we should avoid excessively rigid formalism in this regard. The risk is a separation between ...
Girard Stéphane D - - 2012
The frontal cortex is a brain structure that plays an important role in cognition and is known to be affected in Alzheimer's disease (AD) in humans. Over the past years, transgenic mouse models have been generated to recapitulate the main features of this disease, including cognitive impairments. This study investigates ...
Borówko Małgorzata - - 2012
A density functional theory has been applied to study adsorption from oligomer-monomer solutions on solid surfaces modified with end-grafted polymers. Chains are modeled as freely jointed tangent spheres. All spherical species interact via Lennard-Jones (12-6) potential. The grafted chains are not attracted by the surface. Fluid molecules interact with the ...
Schwalbe Matthias - - 2012
The two different coordination spheres afforded by Pacman architectures offer cooperativity derived from two different metal centers. A modular strategy is developed to produce a hetero-Pacman scaffold featuring a porphyrin and terpyridine for metal-ion binding. A double Suzuki reaction was employed to first attach a terpyridine moiety to a xanthene ...
Dewaele M - - 2012
Volumetric shrinkage reduction is a constant challenge in the improvement of dental resins. The inclusion of hyperbranched polymers (HBPs) with modified functionalities (hydroxyl, propionate, and methacrylate) instead of conventional dimethacrylate monomers has the potential to reduce shrinkage, but can also affect other properties. The null hypothesis was that the addition ...
Ma Haifeng - - 2012
Ice nuclei have been studied on the hexagonal boron nitride nanomesh (h-BN/Rh(111)), a template with 2 nm wide molecule traps. Scanning tunneling microscopy shows confined clus- ters, where oligomers with 3 protrusions are particularly abundant. Together with local barrier height dI/dz maps it is found that the dipoles of the ...
Yan Mi - - 2012
Tuberculosis (TB) is a major health problem, with approximately one-third of the world's population infected with Mycobacterium tuberculosis, eight million people in the active disease state, and two million dying annually. Furthermore, the prevalence of TB/HIV co-infection, and the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) have ...
Birk G K - - 2012
Previous studies have demonstrated conflicting results on the effects of acute exercise on FMD. The aim of the study was to examine brachial artery FMD before and after 3 bouts of acute exercise performed at different intensities. 10 healthy males (mean±SD age: 22±1 years) completed 30 min of cycling at 50, ...
Dismer Florian - - 2012
Chromatography is the method of choice for the separation of proteins, at both analytical and preparative scale. Orthogonal purification strategies for industrial use can easily be implemented by combining different modes of adsorption. Nevertheless, with flexibility comes the freedom of choice and optimal conditions for consecutive steps need to be ...
Annweiler Cedric - - 2012
Vitamin D has been investigated in association with cognitive function in older adults. It is unclear whether hypovitaminosis D could be associated with Alzheimer's disease (AD). Our objective was to systematically review and quantitatively synthesize the association of low serum 25-hydroxyvitamin D (25OHD) concentrations with AD in adults. A Medline ...
- - 2012
In accordance with the Public Health Security and Bioterrorism Preparedness and Response Act of 2002, the Centers for Disease Control and Prevention (CDC) located within the Department of Health and Human Services (HHS) has reviewed the list of biological agents and toxins that have the potential to pose a severe ...
Ohtomo Ryo - - 2012
A 76-year-old man with a history of pontine, cerebellar infaction suddenly became speechless during the procedure of percutaneous coronary intervention. On examination, he was unable to close his mouth voluntarily, but spontaneous closing was preserved when smiling. He had anarthria and hypophonia, although his comprehension was preserved. He also had ...
Hatani Takeshi - - 2012
SUMMARY AT A GLANCE: Septic pulmonary embolism due to periodontal disease (SPE-PD) is rarely reported. We retrospectively reviewed 12 patients with SPE-PD. Most of the cases were not seriously ill. With early diagnosis by contrast-enhanced chest CT, appropriate antimicrobial therapy, and periodontal surgery, resolution of the illness can be expected ...
Chinnagolla Ravi Kiran - - 2012
A highly regioselective ruthenium-catalyzed ortho-arylation of substituted N-alkyl benzamides with aromatic boronic acids in the presence of [{RuCl(2)(p-cymene)}(2)], AgSbF(6), and Ag(2)O is described. Further, ortho-arylated N-alkyl benzamides were converted into fluorenones in the presence of trifluoroacetic anhydride and HCl.
Danso-Abeam Dina - - 2012
The autoimmune regulator, Aire, mediates central tolerance of peripheral self. Its activity in thymic epithelial cells (TECs) directs the ectopic expression of thousands of tissue-restricted antigens (TRAs), causing the deletion of autoreactive thymocytes. The molecular mechanisms orchestrating the breadth of transcriptional regulation by Aire remain unknown. One prominent model capable ...
Utama Robert H - - 2012
Hollow polymeric nanoparticles with a hydrophilic liquid core have been synthesized in a one-pot approach via a novel inverse miniemulsion periphery RAFT polymerization process. Successful encapsulation and release of a model protein is reported as a potential application.
Yano Fumiko - - 2012
OBJECTIVES: To identify a new disease-modifying osteoarthritis drug (DMOAD) candidate that can effectively repair cartilage by promoting chondrogenic differentiation and halt osteoarthritis (OA) progression by suppressing aberrant hypertrophy. METHODS: We screened 2500 natural and synthetic small compounds for chondrogenic agents via four steps using the Col2GFP-ATDC5 system and identified a ...
Kouya Tomoaki - - 2012
Using a co-cultivation system developed previously, positive interaction for cell growth between Bifidobacterium adolescentis and Propionibacterium freudenreichii was evaluated. The total dry cell weight (DCW) of these two strains obtained in the co-cultivation system was 1.5-1.7-fold of the sum of the DCWs obtained in two single cultivations of each bacterium.
Costentin Cyrille - - 2012
Electrochemical conversion of carbon dioxide (CO(2)) to carbon monoxide (CO) is a potentially useful step in the desirable transformation of the greenhouse gas to fuels and commodity chemicals. We have found that modification of iron tetraphenylporphyrin through the introduction of phenolic groups in all ortho and ortho' positions of the ...
McBride Carl - - 2012
The melting point of ice I(h), as well as the temperature of maximum density (TMD) in the liquid phase, has been computed using the path integral Monte Carlo method. Two new models are introduced, TIP4PQ_D2O and TIP4PQ_T2O, which are specifically designed to study D(2)O and T(2)O respectively. We have also ...
Sunasee Rajesh - - 2012
With advances in polymerization techniques as well as selective chemical modification of carbohydrates, glycopolymers and glyco-nanoparticles are emerging as an important class of materials with tailored properties or novel nanotechnology-based platforms for a number of applications. The field of the so-called glyco-nanotechnology is starting to show some promises for future ...
Tripodi Armando - - 2012
BACKGROUND:The new oral anticoagulants (NOAs) dabigatran, rivaroxaban, and apixaban have proved effective and safe when used in clinical trials, without a need to adjust the dose in response to laboratory testing. This demonstrated efficacy does not necessarily mean that the laboratory, considered the mainstay for the management of the old ...
Zhang Meng - - 2012
An artificial peptide with three pendant hydroxyquinoline (hq) ligands on a palindromic backbone was designed and used to form multimetallic assemblies. Reaction of the tripeptide with zinc acetate led to a highly fluorescent tripeptide duplex with three Zn(II) coordinative cross-links. The binding process was monitored using spectrophotometric absorbance and emission ...
Banerjee S - - 2012
BackgroundThe aim of the study is to demonstrate that intrapatient dose escalation of carboplatin would improve the outcome in ovarian cancer compared with flat dosing.Patients and methodsPatients with untreated stage IC-IV ovarian cancer received six cycles of carboplatin area under the curve 6 (AUC 6) 3 weekly either with no ...
Ranatunga Sujeewa - - 2012
Lucentamycin A is a marine-derived peptide natural product harboring a unique 4-ethylidene-3-methylproline (Emp) subunit. The proposed structure of lucentamycin A and the core Emp residue have recently been called into question through synthesis. Here, we report the first total synthesis of lucentamycin A, which confirms that the ethylidene substituent in ...
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