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Wang Hsiang-Tsui HT Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo Park, New York 10987, - - 2013
Acrolein (Acr), an α,β-unsaturated aldehyde, is abundant in tobacco smoke and cooking and exhaust fumes. Acr induces mutagenic α- and γ- hydroxy-1,N(2)-cyclic propano-deoxyguanosine adducts in normal human bronchial epithelial cells. Our earlier work has found that Acr-induced DNA damage preferentially occurs at lung cancer p53 mutational hotspots that contain CpG ...
Liao Linda M LM Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. - - 2013
Despite a well-established link between obesity and renal cell carcinoma (RCC), the mechanism through which obesity acts to increase cancer risk is unclear. Adiponectin, leptin and resistin are adipocyte-secreted peptide hormones that may influence RCC development through their demonstrated effects on inflammation, insulin resistance and cell growth and proliferation. We ...
Torsvik Torbjørn T Norwegian EPR Research Centre, Department of Neuroscience, The Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, - - 2013
To evaluate how clinical chemistry test results were assessed by volunteers when presented with four different visualization techniques. A total of 20 medical students reviewed quantitative test results from 4 patients using 4 different visualization techniques in a balanced, crossover experiment. The laboratory data represented relevant patient categories, including simple, ...
Tran Kim K Department of Pharmacology or Medicine, Dartmouth Medical School, Hanover, NH 03755, - - 2013
Novel drugs and drug combinations are needed for the chemoprevention and treatment of cancer. We show that the histone deacetylase inhibitor vorinostat [suberoylanilide hydroxamic acid (SAHA)] and the methyl ester or ethyl amide derivatives of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Me and CDDO-Ea, respectively) cooperated to inhibit the de novo ...
Fung Erik E Section of Cardiology, Heart & Vascular Center, Lebanon, New Hampshire 03756, USA. - - 2012
The genes encoding the cytochrome P450 2C9 enzyme (CYP2C9) and vitamin K-epoxide reductase complex unit 1 (VKORC1) are major determinants of anticoagulant response to warfarin. Together with patient demographics and clinical information, they account for approximately one-half of the warfarin dose variance in individuals of European descent. Recent prospective and ...
Macneill Christopher M - - 2012
Low band gap D-A conjugated PNs consisting of 2-ethylhexyl cyclopentadithiophene co-polymerized with 2,1,3-benzothiadiazole (for nano-PCPDTBT) or 2,1,3-benzoselenadiazole (for nano-PCPDTBSe) have been developed. The PNs are stable in aqueous media and showed no significant toxicity up to 1 mg · mL(-1) . Upon exposure to 808 nm light, the PNs generated temperatures above 50 °C. ...
Alves Luis G - - 2012
Novel Bn(2)Cyclam-based zirconium complexes of the type (Bn(2)Cyclam)Zr(X)(X') (, X = X' = OPh; , X = X' = SPh; , X = Cl, X' = O(i)Pr) were synthesized in good yields via metathesis routes involving the reaction of the dichloro precursor (Bn(2)Cyclam)Zr(Cl)(2) and the appropriate lithium salts. The molecular ...
Sadeghi Banafsheh - - 2012
BACKGROUND: The FDA-approved dose of low-molecular-weight heparin (LMWH) may not provide adequate thromboprophylaxis in morbidly obese patients after total knee arthroplasty (TKA). Suboptimal dosing, delayed initiation, and overreliance on mechanical methods may also limit the effectiveness of thromboprophylaxis. OBJECTIVE: We explored the associations between the type of thromboprophylaxis, obesity, time ...
Morley John E - - 2012
PURPOSE OF REVIEW: Anorexia represents a major problem for older persons leading to weight loss, sarcopenia, functional decline, and mortality. There is increasing information on the pathophysiological mechanisms that lead to anorexia. RECENT FINDINGS: Increasing evidence has shown the importance of gastrointestinal hormones (ghrelin, cholecystokinin, and glucagon-like peptide) and adipokines ...
Galeone C - - 2012
BackgroundAlcohol is capable of traversing the blood-brain barrier and is thus a possible risk factor for brain cancer. Several epidemiological studies have been published on the issue, a number of those during recent years, with inconsistent findings.Materials and methodsWe performed a systematic literature search in the Medline and EMBASE databases. ...
El Hady Hala Mostafa - - 2012
The aim of the present study was to find out the potential impact of occupational exposure to mixtures of organic solvents on liver function tests. Serum bile acid (BA) was evaluated as a marker of early hepatic derangement and compared to routine liver function tests. The study included two comparable ...
El-Khalawany Mohamed - - 2012
Helicobacter pylori was incriminated as an etiological factor of rosacea. However, there is still controversy about this association. We conducted a comparative study in order to assess the role of H. pylori in rosacea patients who had dyspeptic symptoms. The study included 68 patients and 54 controls. Screening for H. pylori was ...
Yuan Tong-Qi - - 2012
Although the effects of cellulose crystallinity and lignin content as two major structural features on enzymatic hydrolysis have been extensively studied, debates regarding their effects still exist. In this study, reconstitution of cellulose and lignin after 1-ethyl-3-methylimidazolium acetate ([C(2) mim][OAc]) pretreatment was proposed as a new method to study their ...
Tu Huang-Ju - - 2012
OncostatinM (OSM) belongs to IL-6 subfamily and is mostly produced by T lymphocytes. High levels of OSM are detected in the pannus of rheumatoid arthritis (RA) patients and it may arouse the inflammation responses in joints and eventually leads to bone erosion. Placenta growth factor (PLGF) is an angiogenic factor ...
Delubac Daniel - - 2012
Drosophila is one of the most important model organisms in biology. Knowledge derived from the recently sequenced 12 genomes of various Drosophila species can today be combined with the results of more than 100 years of research to systematically investigate Drosophila biology at the molecular level. In order to enable ...
Svensson Anna C - - 2012
The Stockholm Public Health Cohort was set up within the Stockholm County Council public health surveys to inform on determinants and consequences of significant contributors to the current burden of disease. Participants are 89 268 randomly selected individuals from the adult population of Stockholm County. Baseline surveys took place in ...
Kuhnt Daniela - - 2012
Background The reversible posterior leukoencephalopathy (RPL) syndrome with typical vasogenic edema in the occipital lobe and associated cortical blindness is a rare finding; however, the brainstem variant is even more infrequent. Etiologies discussed include blood pressure dysregulations, renal failure, or immunosuppression.Patient A 63-year-old man with the characteristic radiographic findings of RPL syndrome ...
Fowlkes Jason D - - 2012
Liquid metal wires supported on substrates destabilize into droplets. The destabilization exhibits many characteristics of the Rayleigh-Plateau model of fluid jet breakup in vacuum. In either case, breakup is driven by unstable, varicose surface oscillations with wavelengths greater than the critical one (λ(c)). Here, by controlling the nanosecond liquid lifetime ...
Dean Jacob C - - 2012
Single-conformation ultraviolet and infrared spectroscopy has been carried out on the neutral peptide series, Z-(Gly)(n)-OH, n = 1,3,5 (ZGn) and Z-(Gly)(5)-NHMe (ZG5-NHMe) in the isolated environment of a supersonic expansion. The N-terminal Z-cap (carboxybenzyl) provides an ultraviolet chromophore for resonant two-photon ionization (R2PI) spectroscopy. Conformation-specific infrared spectra were recorded in ...
Englund Amir - - 2012
Community-based studies suggest that cannabis products that are high in Δ(9)-tetrahydrocannabinol (THC) but low in cannabidiol (CBD) are particularly hazardous for mental health. Laboratory-based studies are ideal for clarifying this issue because THC and CBD can be administered in pure form, under controlled conditions. In a between-subjects design, we tested ...
Dalen Joakim D - - 2012
Aims: The aim of this study was to test whether the association between self-rated health and mortality differs between educational groups in Norway, and to examine whether health problems and health-related behaviour can explain any of these differences within a previously unexplored contextual setting. Methods: The study used data from ...
Kim Dong Jik - - 2012
Strong interest in resistive switching phenomena is driven by a possibility to develop electronic devices with novel functional properties not available in conventional systems. Bistable resistive devices are characterized by two resistance states that can be switched by an external voltage. Recently, memristors - electric circuit elements with continuously tunable ...
Adeleye Amos O - - 2012
Abstract Background: Tetanus is now a rare disease in the Western world, but not so in developing countries. Cephalic tetanus, unlike some other local forms of the disease, is likely to be fatal. Methods: We describe the clinical presentation of a case of fatal cephalic tetanus complicating an unattended open ...
Montel Sébastien - - 2012
Abstract Background and Objectives: Amyotrophic lateral sclerosis (ALS) is a fatal, neurological disease, which can potentially impact mental health as well as the adaptation process of people who are affected. Most of the results available are cross-sectional. The aim of this study was to study the evolution of coping strategies, ...
Blanford William J - - 2012
In this study, the dynamic interactions between cyclodextrin (CD), an organic chemical and granular activated carbon (GAC) were investigated using column studies. Breakthrough curves of a chlorinated solvent, trichloroethylene (TCE) were obtained over a range of concentrations of 2-hydroxypropyl-beta-cyclodextrin (HPCD) (0, 20, and 50 g L(-1)) and flow velocities (1.0, ...
Lee Soon Dong - - 2012
A novel actinobacterial strain was isolated from a seawater sample collected on Mara Island, Jeju, Republic of Korea. Cells of this organism were aerobic, Gram-positive, non-spore-forming, nonmotile cocci that occurred singly or in pairs. Colonies were circular, smooth, convex and white to cream in color. Phylogenetic analyses based on 16S ...
Kalani M Yashar S - - 2012
Object The threat of symptomatic hemorrhage from cerebral cavernous malformations (CCMs) during pregnancy remains poorly understood. The authors undertook this study to better define the risk of pregnancy-related hemorrhage in this population. Methods The records of female patients with sporadic (isolated lesions and negative family history) and familial forms of ...
Jing Xue-Hui - - 2012
Four coordination polymers, [Co(2)(Hnbpdc)(2)(nbpdc)(bipy)(2)](n) (), [Co(3)(nbpdc)(3)(bipy)(3)(H(2)O)(2)](n)·2nH(2)O (), [Co(4)(nbpdc)(4)(bipy)(H(2)O)(4)](n) (), and [Co(2)(nbpdc)(2)(bpee)(3/2)](n)·0.25nH(2)O () [H(2)nbpdc = 2-nitrobiphenyl-4,4'-dicarboxylic acid, bipy = 4,4'-bipyridine and bpee = 1,2-di(4-pyridyl)ethane] have been synthesized by hydrothermal methods and studied by means of X-ray crystallography, topological analyses and magnetic analyses. Compounds were synthesized from the same reactants under controlled ...
Jasnovidova Olga - - 2012
RNA polymerase II (RNA pol II) is not only the fundamental enzyme for gene expression but also the central coordinator of co-transcriptional processing. RNA pol II associates with a large number of enzymes and protein/RNA-binding factors through its C-terminal domain (CTD) that consists of tandem repeats of the heptapeptide consensus ...
Kochem Amélie - - 2012
One for all: A trianionic ligand containing the biologically relevant moieties, phenolate and porphyrin, was designed and synthesized. One-electron oxidation of the nickel and cobalt complexes of these ligands affords an unprecedented and highly stable hybrid porphyrinyl-phenoxyl radical bound to the metal center. Two-electron oxidation of these complexes leads to ...
Kim Sang Jin - - 2012
To identify proteins that are involved in the molecular mechanisms of oxygen-induced retinopathy (OIR), a well-established model of blinding ischemic retinopathy, we quantitatively analyzed the retinal proteome in a mouse model of OIR. OIR was induced by exposing C57BL/6 mice on postnatal day 7 (P7) to 75% hyperoxia for 5 ...
Hermida M - - 2012
Strongyloides stercolaris is a soil-transmitted intestinal nematode that can carry out its entire life cycle within the human host. It is widely spread throughout the world though it is endemic in tropical and subtropical countries. Clinical manifestations of strongyloidiasis vary in form and severity. Diagnosis is not often easily made ...
Wang Ziren - - 2012
The nucleation process is crucial to many phase transitions, but its kinetics are difficult to predict and measure. We superheated and melted the interior of thermal-sensitive colloidal crystals and investigated by means of video microscopy the homogeneous melting at single-particle resolution. The observed nucleation precursor was local particle-exchange loops surrounded ...
Milazzo Marco - - 2012
Biological responses to warming are presently based on the assumption that species will remain within their bioclimatic envelope as environmental conditions change. As a result, changes in the relative abundance of several marine species have been documented over the last decades. This suggests that warming may drive novel interspecific interactions ...
Weigt R B - - 2012
Impacts of elevated ground-level ozone (O(3)) on nitrogen (N) uptake and allocation were studied on mature European beech (Fagus sylvatica L.) and Norway spruce (Picea abies [L.] Karst.) in a forest stand, hypothesizing that: (i) chronically elevated O(3) limits nutrient uptake, and (ii) beech responds more sensitively to elevated O(3) ...
Han Ming-Jie - - 2012
An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting "aldehyde tag" was presented. A variety of functional groups could be introduced into the protein of interest.
Hou Chuantao - - 2012
(110)-oriented zeolitic imidazolate framework (ZIF)-8 thin films with controllable thickness are successfully deposited on indium tin oxide (ITO) electrodes at room temperature. The method applied uses 3-aminopropyltriethoxysilane (APTES) in the form of self-assembled monolayers (SAMs), followed by a subsequent adoption of the layer-by-layer (LBL) method. The crystallographic preferential orientation (CPO) ...
Bouanane-Darenfed Amel - - 2012
A hyperthermophilic anaerobic bacterium, designated D2C22T was isolated from the hydrothermal hot spring of Guelma in the Northeast Algeria. The strain was Gram-positive, non-sporulated, not motile and rod-shaped, appearing singly or in pairs (0.3-0.4 µm x 8-9 µm). It grew anaerobically at temperatures between 50 and 80 °C (optimum 65 ...
Mamat Constantin - - 2012
Members of the Eph receptor tyrosine kinase family play essential roles in the pathogenesis of cancer and are therefore promising candidates for molecular imaging by positron emission tomography (PET), for example. In this regard, radiochemical access to novel PET radiotracers derived from potent inhibitors that target the EphB4 kinase domain ...
Parker G - - 2012
OBJECTIVE: To determine whether those completing a self-report bipolar self-test measure and identified as having a likely bipolar disorder judged the self-test as useful and had a subsequent superior illness course. METHOD: We invited those completing the web-based Mood Swings Questionnaire (or MSQ) to provide contact details and contribute to ...
Buchneva Olga - - 2012
LaMnO(3), either pure or doped with 10 mol % Sr, has been prepared by flame pyrolysis in nanostructured form. Such catalysts have been tested for the catalytic flameless combustion of methane, achieving very high catalytic activity. The resistance toward poisoning by some model N-containing impurities has been checked in order ...
Horowitz Harold W - - 2012
Background. Lyme disease is transmitted by the bite of Ixodes scapularis ticks, which can also transmit Anaplasma phagocytophilum, the cause of human granulocytic anaplasmosis (HGA). Conflicting data exist on the frequency of co-infection and on whether Lyme-HGA co-infected patients have more symptoms than patients with Lyme disease alone.Methods. Blood culture and serology ...
Hu Bijie - - 2012
BACKGROUND: Little data exist on the burden of device-associated health care-associated infection (DA-HAI) in China. This study examined the DA-HAI rate and evaluated its association with device use (DU), length of stay (LOS), and mortality in intensive care units (ICUs) in 4 Chinese hospitals. METHODS: This was a prospective cohort ...
Destri Giovanni Li - - 2012
The growing interest of pharmaceutical companies toward the crystal morphology prediction of active pharmaceutical ingredients is a consequence of the dramatic effect of the crystal habit on the tableting behavior of drugs. In order to help the optimization of the industrial process, molecular mechanics calculations together with X-ray diffraction analysis ...
Pehlivan Davut - - 2012
Trichothiodystrophy (TTD) is a rare, recessive condition involving multiple organs and systems. Four genes associated with nuclear excision repair have been described in the molecular etiology of TTD. There is a significant heterogeneity of clinical and laboratory findings of TTD, even in individuals carrying the same mutation. Worldwide, approximately 120 ...
Moizé Violeta - - 2012
Wernicke encephalopathy-a debilitating acute or subacute neurological disorder-is caused by a deficiency in thiamine (vitamin B(1)). It is characterized by a classical clinical triad of symptoms: ocular impairment, cerebellar dysfunction, and confusion. Although bariatric surgery can certainly improve the overall health of an obese individual, it can also make him ...
Aakeröy Christer B - - 2012
A robust, facile and solvent-free mechanochemical path for aldehyde-oxime transformations using hydroxylamine and NaOH is explored; the method is suitable for aromatic and aliphatic aldehydes decorated with a range of substituents.
Warf Benjamin C - - 2012
Object It is not known whether previous endoscopic third ventriculostomy (ETV) affects the risk of shunt failure. Different epochs of hydrocephalus treatment at the CURE Children's Hospital of Uganda (CCHU)-initially placing CSF shunts in all patients, then attempting ETV in all patients, and finally attempting ETV combined with choroid plexus ...
Sagawa Motoyasu - - 2012
In order to assess the efficacy of lung cancer screening using low-dose thoracic computed tomography, compared with chest roentgenography, in people aged 50-64 years with a smoking history of <30 pack-years, a randomized controlled trial is being conducted in Japan. The screening methods are randomly assigned individually. The duration of ...
Zhou Panwang - - 2012
The ground and excited state geometries, the excitation and emission energies for a series of fluorescein derivatives in aqueous solutions have been investigated using time-dependent density functional theory (TD-DFT) with B3LYP and a long-range corrected CAM-B3LYP functional. The RI-CC2 method was employed to confirm the CAM-B3LYP results. As far as ...
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