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Results 551 - 600 of 3450
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Peres Rogério Corrêa - - 2012
Abstract The ketogenic diet (KD) was initially developed for the treatment of pharmacoresistant epilepsy and a possible alternative for the obesity treatment, dyslipidemia, resistance to insulin, and non-alcoholic steatosis. However, few studies evaluate the changes on the behavior, motor activity, and anxiety. The objective of this work was to analyze ...
Reyes Vince - - 2012
The use of engineered nanomaterials (eNM) in consumer and industrial products is increasing exponentially. Our ability to rapidly assess their potential effects on human and environment health is limited by our understanding of nano-mediated toxicity. The use of high throughput experimentation enables probeing the nano-mediated toxicity on a genome wide ...
Zheng Jian - - 2012
Interleukin-23 receptor (IL-23R) is a key element in the T-helper 17 (Th17) cell-mediated inflammatory process, which plays an important role in the pathogenesis of cancer. In this study, we examined whether genetic polymorphisms in IL-23R are associated with cancer risk in 4,936 cancer patients and 5,664 control subjects from eastern ...
Duehlmeier R - - 2012
Insulin resistance during late gestation may act as a predisposing factor of ovine pregnancy toxaemia (OPT). To evaluate the insulin action on energy metabolism in ewes with different susceptibilities to OPT, intravenous glucose tolerance tests (1 mmol glucose/kg body weight) were performed in 5.6 ± 0.7 year old, slightly underfed German Blackheaded Mutton ewes ...
Bossi Paolo - - 2012
BACKGROUND: In patients with recurrent and/or metastatic head and neck squamous cell cancer (HNSCC), there are no data about an every-other-week cetuximab maintenance schedule after chemotherapy plus cetuximab as first-line treatment. METHODS: We reviewed the safety and feasibility of every-other-week maintenance cetuximab administered at 3 different European centers. RESULTS: Thirty-one ...
Li Bing - - 2012
Abstract Zinc (Zn) is one of the essential trace elements and has numerous physiological functions. Zn acts as an antioxidant and also as a part of other antioxidant related proteins, such as metallothionein (MT) and Zn-copper superoxide dismutase. Zn deficiency often occurs in patients with diabetes. Therefore, the effect of ...
Gerstner Wulfram W School of Computer and Communication Sciences and Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. - - 2012
Modeling work in neuroscience can be classified using two different criteria. The first one is the complexity of the model, ranging from simplified conceptual models that are amenable to mathematical analysis to detailed models that require simulations in order to understand their properties. The second criterion is that of direction ...
Schmid Thomas E TE Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA 94550, - - 2013
Older men tend to have poorer semen quality and are generally at higher risks for infertility and abnormal reproductive outcomes. We employed proton-induced X-ray emission (PIXE, 3 MeV proton beam) to investigate the concentrations of zinc, copper, calcium, sulfur, chlorine, potassium, titanium, iron and nickel in washed sperm and seminal ...
Wang Tao T Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, - - 2012
5-Hydroxymethylcytosine (5-hmC) is a newly discovered modified form of cytosine that has been suspected to be an important epigenetic modification in neurodevelopment. While DNA methylation dynamics have already been implicated during neurodevelopment, little is known about hydroxymethylation in this process. Here, we report DNA hydroxymethylation dynamics during cerebellum development in ...
Tang Yunan Y Diabetes and Obesity Center, University of Louisville School of Medicine, Louisville, Kentucky, - - 2013
Obesity and type 2 diabetes are emerging global epidemics associated with chronic, low-grade inflammation. A characteristic feature of type 2 diabetes is delayed wound healing, which increases the risk of recurrent infections, tissue necrosis, and limb amputation. In health, inflammation is actively resolved by endogenous mediators, such as the resolvins. ...
Frantseva Marina - - 2012
Schizophrenia is conceptualized as a failure of cognitive integration, and altered oscillatory properties of neurocircuits are associated with its symptoms. We hypothesized that abnormal characteristics of neural networks may alter functional connectivity and distort propagation of activation in schizophrenic brains. Thus, electroencephalography (EEG) responses to transcranial magnetic stimulation (TMS) of ...
Han Won-Sik - - 2012
Visible-light-driven H(2) evolution based on Dye/TiO(2) /Pt hybrid photocatalysts was investigated for a series of (E)-3-(5'-{4-[bis(4-R(1) -phenyl)amino]phenyl}-4,4'-(R(2) )(2) -2,2'-bithiophen-5-yl)-2-cyanoacrylic acid dyes. Efficiencies of hydrogen evolution from aqueous suspensions in the presence of ethylenediaminetetraacetic acid as electron donor under illumination at λ>420 nm were found to considerably depend on the hydrophilic character ...
Hartvigsen J - - 2012
BACKGROUND: Pain from the musculoskeletal system often occurs in more than one site. This appears to affect prognosis negatively. Knowledge about specific pain patterns is lacking. OBJECTIVES: To define specific patterns of musculoskeletal co-complaints occurring alongside a primary musculoskeletal complaint. METHODS: Using data from an interview-based health survey of a ...
Tenea Gabriela N - - 2012
Wheat (Triticum aestivum L.), one of the three most important cereal crops worldwide, has a dominant position in Europe due to its adaptability and consumer acceptance particularly as organic food commodity. Organic agriculture is developing rapidly, and its authenticity is presently a subject of great concern to food authorities, as ...
Blasco Lucia - - 2012
Foam production is an essential characteristic of beer, generated mainly from the proteins present in the malt and, to a minor extent, from the mannoproteins in brewer´s yeast cell walls. Here we describe the isolation and characterization of the novel fermentation gene CFG1 (Carlsbergensis Foaming Gene) from Saccharomyces pastorianus. CFG1encodes ...
Emerenziani G P - - 2012
The aims of this study were to estimate the difference in exercise intensity (METs), energy cost (EE) and gender difference between a typical salsa lesson (TSL), rueda de casino lesson (RCL), and salsa dancing at a night club (SDN). Subjects performed 1 pre-testing session and 3 testing conditions. During the ...
Maloveste Sebastien M - - 2012
The killer cell Ig-like receptors (KIRs) expressed on the surface of NK cells recognize specific MHC class I (MHC-I) molecules and regulate NK cell activities against pathogen-infected cells and neoplasia. In HIV infection, survival is linked to host KIR and MHC-I genotypes. In the SIV macaque model, however, the role ...
Diaz-Stransky Andrea - - 2012
The brain's high concentrations of cholesterol make it especially vulnerable to the cholesterol biosynthetic defect that characterizes Smith-Lemli-Opitz syndrome (SLOS). An attempt to characterize the cognitive and behavioral phenotype of SLOS has identified increased rates of intellectual disability, language and motor developmental delay, repeated self-injury behaviors, sensory hyperreactivity, hyperactivity, affect ...
Langford N J - - 2012
In the UK, the maximal permitted ethanol concentration for driving is 80 mg ethanol/100 mL blood, 35 μg ethanol/100 mL breath or 107 mg ethanol/100 mL urine. Drivers exceeding the prescribed limit face severe penalties, which they are often anxious to avoid, either by acquittal or by putting forward 'special ...
Bi Weimin - - 2012
BACKGROUND: Genomic rearrangements usually involve one of the two chromosome homologues. Homozygous microdeletion/duplication is very rare. The chromosome 22q11.2 region is prone to recurrent rearrangements due to the presence of low-copy repeats. A common 3 Mb microdeletion causes the well-characterised DiGeorge syndrome (DGS). The reciprocal duplication is associated with an ...
Hogh K-Lynn N - - 2012
Lipotoxicity is implicated in pancreatic β-cell dysfunction in obesity-induced type 2 diabetes (T2D). In vitro, activation of peroxisome proliferator-activated receptor alpha (PPARα) has been shown to protect pancreatic β-cells from the lipotoxic effects of palmitate, thereby preserving insulin secretion. Utilizing an adeno-associated virus (dsAAV8), we induced overexpression of PPARα specifically ...
Ramalingam Vijayakumar - - 2012
This paper describes a convenient approach to quantitative removal of the synthetic host cucurbit[8]uril (Q8) from aqueous mixtures using a sepharose resin coated in memantine groups to selectively sequester Q8 in the presence of competing hosts and guests. The "Q8 sponge" can separate Q8 from Q6 and reverse the Q8-mediated ...
Gomez-Ibañez Asier A Department of Neurology and Neurosurgery, Clinica Universidad de Navarra, Pamplona, Spain. - - 2013
To evaluate evolution and elucidate clinical phenotypes related to prognosis of patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) treated exclusively with antiepileptic drugs (AED). Forty-seven out of 68 MTLE-HS patients treated between January 2005 and June 2010 were retrospectively studied for demographic, clinical and outcome data. ...
Gong Yanqing Y Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, No. 8, Xishiku Street, Xicheng District, Beijing 100034, China. - - 2012
Androgen receptor (AR) plays a key role in prostate development and carcinogenesis. Increased expression and/or stability of AR is associated with sensitization of prostate cancer cells to low levels of androgens, leading to castration resistance. Hence, understanding the mechanisms regulating AR protein stability is clinically relevant and may lead to ...
Hossain Md Delwar - - 2012
Stepwise complexation: A green copper-based metallo-supramolecular polymer was successfully synthesized through complexation of Cu(II) ions with new bis(1,10-phenanthroline) ligands. The obtained polymer showed an excellent electrochromic color change from green to colorless upon electrochemical reduction of Cu(II) to Cu(I) .
Frieauff W - - 2012
The in vitro micronucleus test (MNT) is a well-established test for early screening of new chemical entities in industrial toxicology. For assessing the clastogenic or aneugenic potential of a test compound, micronucleus induction in cells has been shown repeatedly to be a sensitive and a specific parameter. Various automated systems ...
Zheng Wen Tao - - 2012
In a study on the diversity of rhizobia isolated from root nodules of Astragalus sinicus, five strains showed identical nucleotide sequences of 16S rRNA gene. They were most related to the type strains of Mesorhizobium loti, M. shangrilense, M. ciceri and M. australicum, with sequence similarities of 99.6 % to ...
Endo Hidenori - - 2012
Object Internal coil trapping is a treatment method used to prevent rebleeding from a ruptured intracranial vertebral artery dissection (VAD). Postoperative medullary infarctions have been reported as a complication of this treatment strategy. The aim of this study was to determine the relationship between a postoperative medullary infarction and the ...
Mesía R - - 2012
BackgroundCetuximab combined with radiotherapy (RT) is a treatment option for head and neck cancer. The objectives of this randomized, phase II trial were to evaluate the efficacy and safety of cetuximab maintenance therapy following definitive RT with concomitant cetuximab in patients with oropharyngeal cancer.Patients and methodsNinety-one patients with stage III-IV ...
Matson Benjamin D - - 2012
Fe(iii)-meso-tetra(pyridyl)porphyrins are electrocatalysts for the reduction of dioxygen in aqueous acidic solution. The 2-pyridyl derivatives, both the triflate and chloride salts, are more selective for the desired 4e(-) reduction than the isomeric 4-pyridyl complexes. The inward-pointing pyridinium groups influence proton delivery despite their distance from the iron centre.
Zhu Yan - - 2012
Flux balance analysis (FBA) has been widely used in calculating steady-state flux distributions that provide important information for metabolic engineering. Several thermodynamics-based methods, e.g. quantitative assignment of reaction directionality and energy balance analysis have been developed to improve the prediction accuracy of FBA. However, these methods can only generate a ...
Mashili Fredirick F Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, - - 2013
Signal transducer and activator of transcription 3 (STAT3) is involved in cytokine- and nutrient-induced insulin resistance. The role of STAT3 in the development of skeletal muscle insulin resistance and type 2 diabetes (T2D) pathogenesis is incompletely defined. We tested the hypothesis that STAT3 signaling contributes to skeletal muscle insulin resistance ...
Li Xiaobo - - 2012
When deprived of nitrogen (N), the photosynthetic microalga Chlamydomonas reinhardtii accumulates large quantities of triacylglycerols (TAGs), making it a promising source of biofuel. Prominent transcriptional changes associated with the conditions leading to TAG accumulation have been found, suggesting that the key enzymes for TAG metabolism might be among those that ...
Wu Ling - - 2012
Adipose-derived stem cells (ASCs) have been discovered for more than a decade. Due to the large numbers of cells that can be harvested with relatively little donor morbidity, they are considered to be an attractive alternative to bone marrow derived mesenchymal stem cells. Consequently, isolation and differentiation of ASCs draw ...
Huynh Cong Truc - - 2012
Novel copolymers containing both anionic and cationic pH-sensitive moieties were reported. These amphoteric copolymers exhibited special closed-loop reversible sol-gel-sol phase transitions in response to both pH and temperature.
Okamura Hirohiko - - 2012
Serine/threonine protein phosphatase 2A (PP2A) participates in regulating many important physiological processes such as cell cycle, growth, apoptosis, and signal transduction. Osterix is a zinc-finger-containing transcription factor that is essential for osteoblast differentiation and regulation of many bone-related genes. We have recently reported that decrease in α-isoform of PP2A catalytic ...
Djawe Kpandja K Veterans Affairs Medical Center, Cincinnati, OH 45267-0560, - - 2013
Pneumocystis pneumonia (PcP) is the second leading cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients in the United States. Although the host risk factors for the development of PcP are well established, the environmental (climatological, air pollution) risk factors are poorly understood. The major goal of this ...
Kothny W - - 2012
AIM: Assess the efficacy and safety of vildagliptin 50 mg bid as add-on therapy to insulin in type 2 diabetes mellitus (T2DM) METHODS: Multicenter, double-blind, placebo-controlled, parallel group, clinical trial in T2DM patients inadequately controlled by stable insulin therapy, with or without metformin. Patients received treatment with vildagliptin 50 mg ...
Papale F - - 2012
Thyroid cancer is not very common, accounting for 1-2% of all cancers, with a population incidence of about 0.004%. Currently, the ability to discriminate between follicular adenoma and carcinoma represents the major challenge in preclinical diagnosis of thyroid proliferative lesions. Better discrimination between the two would help avoid unnecessary thyroidectomy ...
Vataire Anne-Lise - - 2012
Background. In breast cancer, adjuvant chemotherapy is often prescribed as a precautionary measure and sometimes unnecessarily. A diagnostic test based on estimating the risk of recurrence at 10 years for women with breast cancer in early stage has been developed (Oncotype DX(®)). Method. A Markov's model was adapted to evaluate the long-term ...
Amirjani Nasim N Neuroscience Research Australia, University of New South Wales, Hospital Road, Barker Street, Randwick, Sydney, New South Wales 2031, Australia. - - 2012
Costal diaphragm electromyography (EMG) remains unpopular due to the risk of pneumothorax. In this study we assessed the safety of the "trans-intercostal" method of diaphragm EMG using B-mode ultrasound. Twenty healthy subjects participated in this investigation. The diaphragm and the lung were visualized in the most distal intercostal space (dICS) ...
Parsons Jason L JL Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, Roosevelt Drive, Oxford OX3 7DQ, UK. - - 2012
We examined the mechanism regulating the cellular levels of PNKP, the major kinase/phosphatase involved in the repair of oxidative DNA damage, and find that it is controlled by ATM phosphorylation and ubiquitylation-dependent proteasomal degradation. We discovered that ATM-dependent phosphorylation of PNKP at serines 114 and 126 in response to oxidative ...
Ma Li - - 2012
Escherichia coli alkyl hydroperoxide reductase subunit C (AhpC) is a peroxiredoxin that detoxifies peroxides. Here we show an additional role for AhpC in cellular iron metabolism of E. coli. Deletion of ahpC resulted in reduced growth and reduced accumulation of iron by cells grown in low-iron media. Liquid chromatography-mass spectroscopy ...
Loechelt Brett J BJ Children's National Medical Center, Washington, DC, - - 2013
We assessed the morbidity of herpesviruses in patients with type 1 diabetes mellitus (T1D) enrolled in immunosuppressive treatment studies. Epstein-Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV) infections were monitored in 126 participants of a randomized, double-blind, placebo-controlled study of daclizumab (DZB) and mycophenolate ...
Hosoda Ryusuke - - 2013
Resveratrol (trans-3,5,4'-trihydroxystilbene; RSV), a natural polyphenol, exerts a beneficial effect on health and diseases. RSV targets and activates the NAD(+)-dependent protein deacetylase SIRT1; in turn, SIRT1 induces an intracellular antioxidative mechanism by inducing mitochondrial superoxide dismutase (SOD2). Most RSV found in plants is glycosylated, and the effect of these glycosylated ...
Melquiades F L - - 2012
Current methods for quality control of sugarcane are performed in extracted juice, using several methodologies, often requiring appreciable time and chemicals (eventually toxic), turning the methods not green and expensive.The present study proposes the use of X-Ray Spectrometry together with chemometric methods, as an innovative and alternative technique for determining ...
Martin Jodie - - 2012
Movement is fundamental to individual and population dynamics, as it allows individuals to meet their basic requirements. Although movement patterns reflect interactions between internal and external factors, only few studies have examined the effects of these factors on movement simultaneously, and they generally focused on particular biological contexts (e.g. dispersal, ...
Weber Johannes - - 2012
The (31)P chemical shift tensor of the phosphonate group [RC-PO(2)(OH)](-) is investigated with respect to its principal axis values and its orientation in a local coordinate system (LCS) defined from the P atom and the directly coordinated atoms. For this purpose, six crystalline metal aminotris(methylenephosphonates), MAMP·xH(2)O with M = Zn, ...
Mohammadi Marzieh - - 2012
Glucosamine (GlcN) is a major and valuable component in the cell wall of zygomycetes fungi. In this study, a time independent and accurate method was developed for determination of GlcN. In this method, the cell wall was treated via a two-stage sulfuric acid process, and chitin and chitosan were fully ...
Magee C - - 2012
Kisspeptides (KiSS) are a recently discovered family of neuropeptides with a central role in regulating the onset of reproductive function in all animals studied to date. We have established biological and physiological evidence for KiSS signaling in the mare. The objective of the current study was to evaluate the physiological ...
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