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McLaughlin Richard N RN Jr Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9050, - - 2012
Statistical analysis of protein evolution suggests a design for natural proteins in which sparse networks of coevolving amino acids (termed sectors) comprise the essence of three-dimensional structure and function. However, proteins are also subject to pressures deriving from the dynamics of the evolutionary process itself--the ability to tolerate mutation and ...
Manjarrez-Orduño Nataly N Center for Autoimmune and Musculoskeletal Disorders, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish, Manhasset, New York, - - 2012
The c-Src tyrosine kinase, Csk, physically interacts with the intracellular phosphatase Lyp (encoded by PTPN22) and can modify the activation state of downstream Src kinases, such as Lyn, in lymphocytes. We identified an association of CSK with systemic lupus erythematosus (SLE) and refined its location to the intronic polymorphism rs34933034 ...
Southwell Derek G DG Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA. - - 2012
Cortical inhibitory circuits are formed by γ-aminobutyric acid (GABA)-secreting interneurons, a cell population that originates far from the cerebral cortex in the embryonic ventral forebrain. Given their distant developmental origins, it is intriguing how the number of cortical interneurons is ultimately determined. One possibility, suggested by the neurotrophic hypothesis, is ...
Volbeda Franke - - 2013
Control of asthma is the goal of asthma management worldwide. The Global Initiative for Asthma defined control by a composite measure of clinical findings and future risk but without using markers of airway inflammation, the hallmark of asthma. We investigated whether clinical asthma control reflects eosinophilic inflammation in a broad ...
- - 2012
Bovine TB, veterinary surveillance, dog breeding and 'one health' were all subjects on which the UK's chief veterinary officers answered questions at this year's BVA Congress. Kathryn Clark reports on the 'Ask the CVOs' session, at which the four CVOs gave their views on a range of topical issues raised ...
Schachtman Daniel P - - 2012
This research highlight does not have an abstract.
- - 2012
People have many concerns about managing other people, says Helen Frewin, who will discuss this subject at the BVA Careers Fair at the London Vet Show on November 16. Here, she describes managers' concerns and the issues that she will expand upon.
Peres Rogério Corrêa - - 2012
Abstract The ketogenic diet (KD) was initially developed for the treatment of pharmacoresistant epilepsy and a possible alternative for the obesity treatment, dyslipidemia, resistance to insulin, and non-alcoholic steatosis. However, few studies evaluate the changes on the behavior, motor activity, and anxiety. The objective of this work was to analyze ...
Reyes Vince - - 2012
The use of engineered nanomaterials (eNM) in consumer and industrial products is increasing exponentially. Our ability to rapidly assess their potential effects on human and environment health is limited by our understanding of nano-mediated toxicity. The use of high throughput experimentation enables probeing the nano-mediated toxicity on a genome wide ...
Fargen Kyle M - - 2012
INTRODUCTION: A number of recent trials evaluating intra-arterial therapies for acute ischemic stroke have been completed. We present a review of prospective acute ischemic stroke trials reported in a peer-reviewed forum during the last 20 years to provide insight into the general direction of this rapidly evolving field. METHODS: Prospective ...
Norinder Ulf - - 2012
Uncertainty was introduced to chemical descriptors of 16 publicly available datasets to various degrees and in various ways in order to investigate the effect on the predictive performance of the state-of-the-art method ensembles of decision trees. A number of strategies to handle uncertainty in ensembles of decision trees were evaluated. ...
- - 2012
The following information has been produced for Veterinary Record by the Veterinary Medicines Directorate (VMD) to provide an update for veterinary surgeons on recent changes to marketing authorisations for veterinary medicines in the UK and on other relevant issues.
Harrison Amy S - - 2012
This article introduces the use of qualitative research techniques in the field of radiation oncology with respect to quality improvement initiatives. The qualitative techniques used in this research include field observations and in-depth, one-on-one interviews with radiation therapy technologists. The observations were conducted in a fast-paced academic institution. This high-pressure, ...
Kolnagou Annita - - 2012
Abstract The importance of spleen iron and splenectomy has been investigated in 28 male and 19 female β-thalassemia major (β-ΤΜ), adult patients. In one study an increase from about five (615g;19.5 × 11.0 × 6.0 cm) to twenty (2030g; 25.0 × 17.5 × 12.0 cm) times higher than the normal size and weight of spleen has been observed ...
Bates Shannon M - - 2012
D-dimer is a global indicator of coagulation activation and fibrinolysis and, therefore, an indirect marker of thrombotic activity. The utility of D-dimer measurement has been evaluated in several clinical situations including the exclusion of venous thromboembolism (VTE), prediction of future risk of VTE, and the diagnosis and monitoring of disseminated ...
- - 2012
Now one-year qualified, Jen Hall feels that she has moved on from being a new graduate to becoming a recent graduate. She is the BVA's new recent graduate representative on Council.
Appleton Richard E - - 2012
The epilepsies of childhood are a heterogeneous group of disorders with different causes, treatments and outcomes. The choice of anti-epileptic drug is largely determined by its effectiveness in a specific epilepsy syndrome, or seizure type(s) if a syndrome cannot be readily identified, and the drug's safety profile. There are minimal ...
Douglas Simon - - 2012
This article attempts to answer two basic questions. First, can body parts be the subject of property rights? This requires us to start with a definition of property rights, and this is set out in the first section. In the second section, it will be argued that rights in relation ...
Dy Irene A - - 2012
The syndrome of cocaine-levamisole thrombotic vasculopathy is a tetrad of cutaneous manifestations, arthralgia, leukopenia, and positive antineutrophil cytoplasmic antigen (ANCA). Cocaine is cut with levamisole to potentiate its euphoric effects. However, along with this are the adverse reactions of levamisole such as fatal agranulocytosis, flu-like symptoms, and cutaneous thrombotic vasculopathy. ...
- - 2012
In his address to the Association's annual congress last week, the outgoing BVA President Carl Padgett described some of the areas in which the Association had been active during his year as president and how the congress programme reflected the theme he had chosen, 'Delivering a healthy future'.
Mirri Francesca - - 2012
Transparent conductive carbon nanotube (CNT) films were fabricated by dip coating solutions of pristine CNTs dissolved in chlorosulfonic acid (CSA) and then removing the CSA. The film performance and morphology (including alignment) were controlled by the CNT length, solution concentration, coating speed, and level of doping. Using long CNTs (~10 ...
Manso Paulo H - - 2012
OBJECTIVES: To investigate whether perioperative serum levels of oxidative stress markers, thiobarbituric acid reactive substances (TBARS), and carbonyl moieties are associated with outcomes in children after heart surgery. BACKGROUND: Oxidative stress markers are increased following heart surgery with cardiopulmonary bypass (CPB) and can play a role in ischemia-reperfusion injury, but ...
Chung Lorinda - - 2012
OBJECTIVE: The UCSD Shortness-of-Breath Questionnaire (SOBQ) has been used to assess dyspnea-related activitylimitation in patients with airway and parenchymal lung disease. We sought to assess the constructvalidity and responsiveness of the SOBQ in systemic sclerosis (SSc) patients with incident pulmonary hypertension(PH) and those at high risk for developing PH. METHODS: ...
- - 2012
BVA members can benefit from free one-to-one sessions from specialist careers, legal and financial advisers at the BVA Careers Fair at the London Vet Show 2012.
Maclean Joanna E - - 2012
OBJECTIVE: To determine the prevalence of sleep-disordered breathing (SDB) symptoms and respiratory events during sleep in infants with cleft lip and/or palate (CL/P). DESIGN: Prospective observational study. SETTING: Cleft palate clinic, tertiary care paediatric hospital, before palate surgery. PATIENTS: Consecutive newborn infants with CL/P. MAIN OUTCOME MEASURES: Demographics, clinical history, ...
Mellor D D - - 2012
AIMS: To investigate the effects of high-polyphenol chocolate upon endothelial function and oxidative stress in Type 2 diabetes mellitus during acute transient hyperglycaemia induced following a 75-g oral glucose challenge. METHODS: Ten subjects with Type 2 diabetes underwent a double-blinded randomized controlled crossover study. A 75-g oral glucose load was used to ...
Behrens Frank - - 2012
OBJECTIVE: To determine the "real-world" clinical effectiveness and safety of leflunomide in patients with psoriatic arthritis (PsA). METHODS: This prospective, multinational 24-week observational study involved adult patients with active PsA who initiated treatment with leflunomide.Patients were evaluated at baseline, 12 weeks, and 24 weeks.The primary outcome was response as assessed ...
Auerbach Evan - - 2012
With the advent of highly active antiretroviral therapy (HAART), dramatic improvements have been made in the quality and length of life in people living with HIV/AIDS (PLWA). Complications that are seen with increasing frequency in this group include venous thromboembolism events (VTE) and cardiovascular disease. Recent epidemiologic studies suggest PLWA ...
Nick Sabine - - 2012
Chloroplast-located proteins which are encoded by the nuclear genome have to be imported from the cytosol into the organelle in a post-translational manner. Among these nuclear-encoded chloroplast proteins are the light-harvesting chlorophyll a/b-binding proteins (LHCPs). After translation in the cytosol, precursor proteins of LHCPs are imported via the TOC/TIC translocase, ...
- - 2012
The Nominations and Awards Group met in July to select 16 new committee members for the BVA's five Standing Committees - the BVA Animal Welfare Foundation, the Ethics and Welfare Group, the Members' Services Group, the Overseas Group and the Veterinary Policy Group. The new members come from a variety ...
Ni Mhurchu Cliona - - 2012
BACKGROUND: Free school breakfast programmes (SBPs) exist in a number of high-income countries, but their effects on educational outcomes have rarely been evaluated in randomised controlled trials. METHODS: A 1-year stepped-wedge, cluster randomised controlled trial was undertaken in 14 New Zealand schools in low socioeconomic resource areas. Participants were 424 ...
Horie Masaki - - 2012
This paper presents a pseudorotaxane that acts as a thermally-driven molecular switch in the single-crystal state. Crystals of the cationic pseudorotaxane consisting of dibenzo[24]crown-8 (DB24C8) and N-(xylylammonium)-methylferrocene as the cyclic and axle component molecules, respectively, undergo crystalline-phase transition at 128 °C with heating and 116 °C with cooling, according to ...
Xu Bing - - 2012
Plant growth requires cell wall extension. The cotton AtRD22-Like 1 gene GhRDL1, predominately expressed in elongating fiber cells, encodes a BURP domain-containing protein. Here, we show that GhRDL1 is localized in cell wall and interacts with GhEXPA1, an α-expansin functioning in wall loosening. Transgenic cotton over-expressing GhRDL1 showed an increase ...
Duehlmeier R - - 2012
Insulin resistance during late gestation may act as a predisposing factor of ovine pregnancy toxaemia (OPT). To evaluate the insulin action on energy metabolism in ewes with different susceptibilities to OPT, intravenous glucose tolerance tests (1 mmol glucose/kg body weight) were performed in 5.6 ± 0.7 year old, slightly underfed German Blackheaded Mutton ewes ...
Bossi Paolo - - 2012
BACKGROUND: In patients with recurrent and/or metastatic head and neck squamous cell cancer (HNSCC), there are no data about an every-other-week cetuximab maintenance schedule after chemotherapy plus cetuximab as first-line treatment. METHODS: We reviewed the safety and feasibility of every-other-week maintenance cetuximab administered at 3 different European centers. RESULTS: Thirty-one ...
Li Bing - - 2012
Abstract Zinc (Zn) is one of the essential trace elements and has numerous physiological functions. Zn acts as an antioxidant and also as a part of other antioxidant related proteins, such as metallothionein (MT) and Zn-copper superoxide dismutase. Zn deficiency often occurs in patients with diabetes. Therefore, the effect of ...
Algar Elena - - 2012
Phytopharmaceuticals are plant secondary metabolites strongly inducible and especially sensitive to biotic changes. Plant cell cultures are a good alternative to obtain secondary metabolites, in case effective stimulation can be achieved. In this study metabolic elicitors from two rhizobacteria able to enhance isoflavone content in soybean seedlings, were tested on ...
Peters Jan-Michael - - 2012
During S phase, not only does DNA have to be replicated, but also newly synthesized DNA molecules have to be connected with each other. This sister chromatid cohesion is essential for the biorientation of chromosomes on the mitotic or meiotic spindle, and is thus an essential prerequisite for chromosome segregation. ...
Britzen-Laurent Nathalie - - 2012
The human guanylate-binding protein 1 (GBP-1) is among the proteins the most highly induced by IFN-γ in every cell type investigated as yet. In vivo, GBP-1 expression is associated with the presence of inflammation and has been observed in autoimmune diseases, inflammatory bowel diseases (IBD) and cancer. In colorectal carcinoma ...
Yu Wei-Hsuan - - 2012
ABSTRACT: There is a major mistake in the order of figure 6 and figure 7 in [1]. We replace the correct original order of figure 6 and figure 7 in this correction. We also replced with new corrected figures of figure 5 and figure6. Sorry for the inconveniences!
Takase Mitsuyo - - 2012
The transfer of nuclei of fully differentiated cells into enucleated oocytes is a well-recognized method for the generation of embryonic stem (ES) cells. Here, we demonstrate that nuclear transferred ES (NT-ES) cells can be established with high efficiency using innate-like B lymphocytes as donor cells. We established two mouse lines ...
- - 2012
From 2013, the British Veterinary Association's annual Congress will take place at the London Vet Show. The partnership between the BVA and the Vet Show was announced by outgoing BVA President Carl Padgett at the opening ceremony of this year's BVA Congress, as he welcomed delegates and guests to Liverpool.
Zheng Jian - - 2012
Interleukin-23 receptor (IL-23R) is a key element in the T-helper 17 (Th17) cell-mediated inflammatory process, which plays an important role in the pathogenesis of cancer. In this study, we examined whether genetic polymorphisms in IL-23R are associated with cancer risk in 4,936 cancer patients and 5,664 control subjects from eastern ...
- - 2012
Alistair Dornan, head of consultancy at Bupa Health and Wellbeing, will discuss managing stress in the workplace at the BVA Careers Fair at the London Vet Show.
Mahmoud Mohamed A - - 2012
OBJECTIVE: We applied quality improvement methodology to identify unnecessary, redundant parts of processes that can lead to delayed on-time starts for patients scheduled with general anesthesia (GA) in the radiology department. AIM: To address the issue of delayed on-time starts by improving work flow for the first patient scheduled with ...
Lee Yun Jong - - 2012
OBJECTIVES: To identify non-major histocompatibility complex susceptible genes that might contribute to Behçet's disease (BD). METHODS: We performed a genome-wide association study using DNA samples from a Korean population consisting of 379 BD patients and 800 controls. A replication study was performed in a Japanese population (363 BD patients and ...
Dong Yaa-Hui - - 2013
The active-treatment comparative safety information for all inhaled medications in patients with chronic obstructive pulmonary disease (COPD) is limited. We aimed to compare the risk of overall and cardiovascular death for inhaled medications in patients with COPD. Through systematic database searching, we identified randomised controlled trials of tiotropium Soft Mist ...
Gioiello Antimo - - 2012
The G protein-coupled receptor TGR5 is a key player of the bile acid signaling network, and its activation has been proved to increase the glycemic control, to enhance energy expenditure and to exert anti-inflammatory actions. Accordingly, TGR5 ligands have emerged in drug discovery and preclinical appraisals as promising agents for ...
Kang Ning N Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The - - 2013
In order for computers to extract useful information from unstructured text, a concept normalization system is needed to link relevant concepts in a text to sources that contain further information about the concept. Popular concept normalization tools in the biomedical field are dictionary-based. In this study we investigate the usefulness ...
Wang Hsiang-Tsui HT Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo Park, New York 10987, - - 2013
Acrolein (Acr), an α,β-unsaturated aldehyde, is abundant in tobacco smoke and cooking and exhaust fumes. Acr induces mutagenic α- and γ- hydroxy-1,N(2)-cyclic propano-deoxyguanosine adducts in normal human bronchial epithelial cells. Our earlier work has found that Acr-induced DNA damage preferentially occurs at lung cancer p53 mutational hotspots that contain CpG ...
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