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Results 351 - 400 of 2845
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Mulcahy Ben - - 2012
Frailty is a feature of neuromuscular ageing. Here we provide insight into the relative contribution of pre and postsynaptic dysfunction to neuromuscular ageing using the nematode Caenorhabditis elegans. Assays of C. elegans motility highlight a precipitous decline during ageing. We describe a novel deployment of pharmacological assays of C. elegans ...
Piovezan Ronaldo D - - 2012
A challenging aspect of geriatric practice is that it often requires decision-making under conditions of uncertainty. The Script Concordance Test (SCT) is an assessment tool designed to measure clinical data interpretation, an important element of clinical reasoning under uncertainty. The purpose of this study was to develop and analyze the ...
Kitchen Dianne Patricia - - 2012
BACKGROUND: Vitamin K antagonists have been used for many decades and have been traditionally monitored by the measurement of the International Normalised Ratio (INR) in the laboratory. Introduction of Point of Care (POC) testing devices to measure INR has resulted in many tests being undertaken in primary care. External Quality ...
Singhal Dhruv - - 2012
Background Perforator flap breast reconstruction requires increased time for safe perforator dissection, especially the intramuscular course. We describe an adjunctive technique using hydrodissection to assist with the intramuscular perforator dissection.Methods Hydrodissection techniques were used for perforator dissection in 45 consecutive patients (64 flaps) undergoing deep inferior epigastric perforator (DIEP) flap breast reconstruction. ...
Liu Yan-Lin - - 2012
Magnetic-fluorescent particles with targeting functionalities were fabricated by a modified Stöber method and two shapes (spherical and beanpod-like) were obtained by simply tuning the reaction temperature. The two multifunctional probes combined the useful functions of magnetism, fluorescence and FA (folic acid)-targeting recognition into one entity. The products were characterized by ...
Liu Po-Yen - - 2012
BACKGROUND: The androgen receptor (AR) is a main therapeutic target for treatment of prostate cancer (PCa). The natural compound isochaihulactone (K8), which has a chiral center ring and two racemic forms (E-K8 and Z-K8), has anti-tumor effects on multiple cancer types both in vitro and in vivo. Here, we determined ...
Sultan Babar - - 2012
BACKGROUND: Vitamin D, long recognized for its role in bone metabolism and calcium homeostasis, has been increasingly shown to augment innate immunity. 1-α-Hydroxylase, the enzyme responsible for the synthesis of active vitamin D, has been shown to have extrarenal expression in multiple cell types, including airway epithelial cells. The purpose ...
Rosenberger Hale Erica Lyn - - 2012
BACKGROUND: Physical inactivity contributes to metabolic syndrome (MetS) in overweight/obesity. However, little is known about this relationship in prediabetes. METHODS: The study purpose is to examine relationships between physical activity (PA) and MetS in prediabetes. The Healthy Living Partnerships to Prevent Diabetes tested a community translation of the Diabetes Prevention ...
Zhou Tao - - 2012
Putting the DNA in dendrimers: A strategy to swiftly prepare DNA dendrimers based solely on DNA self-assembly is presented. This technique produces highly pure DNA dendrimers with an excellent yield of high generation dendrimers. The incorporation of molecular motors (i-motifs) into the DNA dendrimers allows for a change in size ...
Wang Jay Ching Chieh - - 2012
BACKGROUND: There is a need to find an animal model to study new medications to improve mucosal wound healing after functional endoscopic sinus surgery (FESS). Current literature suggests swine as a potential candidate. The lack of information correlating swine computer tomography (CT) and endoscopic sinonasal anatomy prompted us to investigate ...
Legrand Baptiste - - 2012
BAC for more: A constrained bicyclic building block with urea linkages is an efficient combination for the formation of a highly rigid helical system. This type of bicyclic amino carbamoyl (BAC) foldamer was studied both in solution and in the solid state. A robust H-bond (dotted line) network was found ...
Li Shiming - - 2012
Tea is the most popular flavored and functional drink worldwide. The nutritional value of tea is mostly from the tea polyphenols that are reported to possess a broad spectrum of biological activities, including anti-oxidant properties, reduction of various cancers, inhibition of inflammation, and protective effects against diabetes, hyperlipidemia and obesity. ...
Ait-Ouazzou Abdenour - - 2012
AIMS: To study the mechanism of bacterial inactivation by carvacrol and the influence of genetic and environmental factors in its antimicrobial activity. METHODS AND RESULTS: In general, bacterial inactivation by carvacrol was higher in the Gram-positive Listeria monocytogenes than in the Gram-negative Escherichia coli and at acidic pH. At pH ...
Wu Yili - - 2012
Abnormal expression of regulator of calcineurin 1 (RCAN1) has been implicated in Alzheimer's disease (AD) and Down's syndrome (DS). There are two major isoforms of RCAN1, isoforms 1 and 4. RCAN1 isoform 1 is predominantly expressed in the brain, particularly in neurons. In this report, we showed that there are ...
Graham Erin R - - 2012
Each spring, North American spotted salamander (Ambystoma maculatum) females each lay hundreds of eggs in shallow pools of water. Eggs are surrounded by jelly layers and deposited as large gelatinous masses. Following deposition, masses are penetrated by a mutualistic green alga, Oophila amblystomatis, which enters individual egg capsules, proliferates, and ...
Massey Mark Kieran - - 2012
Langmuir-Blodgett deposition has been used to form thin film networks of both metallic and semiconducting single-walled carbon nanotubes. These have been investigated to understand their physical, optical and morphological properties. The electrical conductivities over the temperature range 80 K to 350 K and across electrode spacings of 220 nm and ...
Ma Ya-Tuan - - 2012
Several series of forty-five acetophenone derivatives bearing various alkyl or benzyl substituents were conveniently synthesized and their structures characterized by (1) H and (13) C NMR spectroscopy, HRMS and single crystal X-ray analysis. Their in vitro antifungal activities against a panel of phytopathogenic fungi were evaluated by mycelial growth rate ...
Brito Renan G - - 2012
Citronellol (CT) is a monoterpenoid alcohol present in the essential oil of many medicinal plants, such as Cymbopogom citratus. We evaluated the antinociceptive effects of CT on orofacial nociception in mice and investigated the central pathway involved in the effect. Male Swiss mice were pre-treated with CT (25, 50 and ...
Gasparini Giorgio - - 2012
ABSTRACT: INTRODUCTION: Insulin-like growth factor I (IGF-I) regulates articular cartilage homeostasis. During osteoarthritis (OA), the anabolic responses of chondrocytes to IGF-I are likely to be prevented by the enhanced production of IGF binding proteins (IGFBPs), especially IGFBP-3. The aim of this study is to evaluate whether the architectural transcription factor ...
Bansal Minakshi - - 2012
Abstract Data on Quality of life (QOL) specifically in maintenance therapy of acute lymphoblastic leukemia (ALL) is minimal. This study was done to assess varied items listed in domains of QOL (physical, emotional, social and school health domains) of children with ALL during maintenance therapy, and compare the same with ...
Koh Travis L - - 2012
Vertically aligned metal oxide nanostructures (e.g., wires, needles, pillars and trees) of CuO, PdO and NiO were synthesized on several substrates (e.g., Si and ITO (indium tin oxide)) using a high-pressure (∼Torr) microplasma-based growth technique. Organometallic precursors were dissociated in the hollow cathode region of a supersonic plasma jet creating ...
Joo Kisu - - 2012
Although graphene looks attractive to replace indium tin oxide (ITO) in optoelectronic devices, the luminous efficiency of light emitting diodes (LEDs) with graphene transparent conducting electrodes has been limited by degradation in graphene taking place during device fabrication. In this study, it was found that the quality of graphene after ...
Dorniak-Wall Taisa - - 2012
BACKGROUND: A peripheral intravenous device (PIVD) provides venous access for the administration of medications, blood products and fluids. They can be associated with a risk of infection and other complications, which have prompted the development of evidence-based guidelines for their use at the Royal Adelaide Hospital (RAH). A previous audit ...
Xie Weilong - - 2012
Top cat: [(NHC)Yb{N(SiMe(3) )(2) }(2) ] adducts (NHC=N-heterocyclic carbene) are efficient catalysts for catalytic cross-dehydrogenative coupling of silanes with a range of primary and secondary amines to yield silylamines in high yields (82-100 %) under mild reaction conditions. The catalytic activity and selectivity of the rare-earth-metal silylamides are modulated by altering ...
Coon Elizabeth A - - 2012
Our objective was to characterize the motor neuron disease features within a large c9FTD/ALS kindred. We analyzed clinical, electrophysiologic and neuropathologic data in a c9FTD/ALS kindred of Scandinavian ancestry. Results showed that of six family members affected, three had only ALS, two had FTD and one had FTD and ALS. ...
Crogan Neva L - - 2012
Background: This article describes the testing of a new nursing home food delivery system that empowers elders to choose the foods they want to eat and gives them an active voice in menu development. Methods: Using a 2-group, repeated measures design, 61 elderly residents from 2 eastern Washington nursing homes ...
Steinmetz Heinrich - - 2012
The gliding bacterium Sandaracinus amylolyticus, strain NOSO-4T, was recently characterized as the first representative of a new myxobacterial genus. A screening of the culture broth for antibiotically active metabolites followed by isolation and characterization revealed two unique 3-formylindol derivatives, indiacen A (1) and its chloro derivative indiacen B (2). Both ...
Manickam Gowri - - 2012
Silver thin films are well known as the most sensitive material for surface plasmon resonance (SPR) based analysis. However, the use of silver for this purpose is limited by three main issues, namely poor adhesion to plastic substrates, chemical instability in both air and aqueous environments and hence the difficulty ...
Jahnukainen Kirsi - - 2012
Context:Rapid progress in fertility preservation strategies has led to the investigation of ways in which fertile gametes could be generated from cryopreserved immature testicular tissue. Childhood cancer patients remain the major group that can benefit from these techniques. Other potential candidates include patients undergoing gonadectomy and patients with Klinefelter's syndrome ...
Hofmann A - - 2012
BACKGROUND: Balancing treatment benefits and risks is part of a shared decision-making process before initiating any treatment in multiple sclerosis (MS). Patients understand, appreciate and profit from evidence-based patient information (EBPI). While these processes are well known, long-term risk awareness and risk processing of patients has not been studied. Mitoxantrone ...
Berl Tomas - - 2012
Hyponatremia is the most common electrolyte disorder. With the aging of the population and the greater propensity of the elderly to develop hyponatremia, this electrolyte disorder is of increasing importance to the practicing nephrologist. In this Attending Rounds, an illustrative patient with hyponatremia is presented. The reasons for the increased ...
Kang Soonchul - - 2012
The reaction of Co(NO(3))(2)·6H(2)O and 3-benzoylpyridine with the low-spin iron(iii) complex, H[Fe(III)(phen)(CN)(4)], in methanol gives rise to a cyanide-bridged heterobimetallic chain [{Fe(III)(phen)(CN)(4)}(2)Co(II)(3-bpe)(2)] () that exhibits intrachain ferromagnetic coupling and slow double magnetic relaxation.
Kim Joon Bum - - 2012
BACKGROUND: Although recent studies contributed to an improved understanding of the prognosis of patients undergoing tricuspid valve (TV) surgery, the data are limited to certain causes of tricuspid regurgitation (TR) or types of surgery. OBJECTIVE: This study aimed to identify predictors of clinical outcomes of patients undergoing TV surgery for ...
Clarsen Benjamin - - 2012
BACKGROUND: Current methods for injury registration in sports injury epidemiology studies may substantially underestimate the true burden of overuse injuries due to a reliance on time-loss injury definitions. OBJECTIVE: To develop and validate a new method for the registration of overuse injuries in sports. METHODS: A new method, including a ...
Kim Hye Sung - - 2012
ABSTRACT: INTRODUCTION: TLR4 promotes joint inflammation in mice. Despite that several studies report a functional link between TLR4 and IL-1in arthritis, TLR4-mediated regulation of the complicated cytokine network in arthritis is poorly understood. To address this, we investigated the mechanisms by which TLR4 regulates the cytokine network in antibody-induced arthritis. ...
Kosicka Anna - - 2012
Obesity-related metabolic disorders are characterized by mild chronic inflammation, leukocyte infiltration, and tissue fibrosis as a result of adipocytokine production from the expanding white adipose tissue. Annexin A1 (AnxA1) is an endogenous glucocorticoid regulated protein, which modulates systemic anti-inflammatory processes and, therefore, may be altered with increasing adiposity in humans. ...
Berg Karl S - - 2012
Parrots rely heavily on vocal signals to maintain their social and mobile lifestyles. We studied vocal ontogeny in nests of wild green-rumped parrotlets (Forpus passerinus) in Venezuela. We identified three successive phases of vocal signaling that corresponded closely to three independently derived phases of physiological development. For each ontogenetic phase, ...
Imayama Ikuyo - - 2012
BACKGROUND: Regular exercise increases exercise self-efficacy and health-related quality of life (HRQOL); however, the mechanisms are unknown. We examined the associations of exercise adherence and physiological improvements with changes in exercise self-efficacy and HRQOL. METHODS: Middle-aged adults (N=202) were randomized to 12 months aerobic exercise (360 minutes/week) or control. Weight, ...
Pruden Amy - - 2012
Antimicrobial resistance remains a serious and growing human health challenge. The water environment may represent a key dissemination pathway of resistance elements to and from humans. However, quantitative relationships between landscape features and antibiotic resistance genes (ARGs) have not previously been identified. The objective of this study was to examine ...
Mahadevan Raynuha - - 2012
Introduction.  Decreased libido is recognized as one of the vegetative symptoms of depression. Increased libido has not been acknowledged as one of its symptoms, neither has it been reported, particularly in depressed bipolar patients. Aim.  We hereby report a case of atypical presentation of increased sexual function in a patient ...
Wu F - - 2012
The main objective of this study was to investigate the pharmacokinetic characters of eszopiclone (CAS: 138729-47-2) after single and multiple-dose oral administration in healthy adult Chinese volunteers.In single-dose study, 12 subjects were given oral administrations of 1.5, 3 and 6 mg eszopiclone in an open-label, randomized, crossover fashion. In multiple-dose study, ...
Ritchie David - - 2012
Criteria used in the evaluation and selection of applicants for clinical neuropsychology internships were identified by a survey of programs that met guidelines for specialty training. The number of internships that offer training with specialization in clinical neuropsychology has more than doubled during the past 10 years. Supervising neuropsychologists from ...
Tu Yawei - - 2012
The radical cyclization between aliphatic acyclic esters and alkenes was achieved unprecedentedly in the presence of allylsamarium bromide with HMPA and H(2)O as additives. The cascade radical cyclization-ring-opening-anionic cyclization allowed facile and efficient access to 2-(2-hydroxyalkyl)cyclopropanols from readily available materials.
Kroes Geert-Jan - - 2012
This perspective addresses four challenges facing theorists whose aim is to make quantitatively accurate predictions for reactions of molecules on metal surfaces, and suggests ways of meeting these challenges, focusing on dissociative chemisorption reactions of H(2), N(2), and CH(4). Addressing these challenges is ultimately of practical importance to a more ...
Shoja Mohammadali M - - 2012
Today, the study of human anatomy utilizing the ultimate study guide, the cadaver, is relatively safe. In the past, however, human dissection was dangerous. Prior to the germ theory, antibiotics, and the use of gloves, cadavers were often life threatening to dissectors including both the teacher and the student. Medical ...
Lee Yu Kyung - - 2012
1. Protein-calorie malnutrition (PCM) could occur frequently in cancer patients and alter the pharmacokinetics of drugs. Also cysteine shows anti-oxidative effect and changes the activities of drug metabolizing enzyme and/or transporters. Herein, we investigated the effects of cysteine on the pharmacokinetics of tamoxifen in rats with protein-calorie malnutrition (PCM). 2. The in ...
Gauri Samiran S - - 2012
AIMS: To examine tannic acid (TA) utilization capacity by nitrogen fixing bacteria, Azotobacter sp. SSB81 and identify the intermediate products during biotransformation. Another aim of this work is to investigate the effects of TA on major biopolymers (EPS and PHB) synthesis. METHODS AND RESULTS: Tannic acid utilization and tolerance capacity ...
Song Zhiguang - - 2012
In this study silica nanoparticles (SiNPs) were covalently modified by the fluorescence ligand 2-((7-oxo-7H- furo [3, 2-g] chromen-9-yl) oxy)-N-(3-(triethoxysilyl) propyl) acetamide (CTPA) and provided an optical sensor allowing highly sensitive and selective detection for Au(3+). The probe exhibited a dynamic response range for Au(3+) from 5.0 × 10(-7) to 1.0 × 10(-4) M, with a ...
Zeng Xianghui - - 2012
Dendrimers and their less well defined cousins, hyperbranched polymers, are widely investigated as scaffold materials in tissue engineering, as drug delivery agents, and in diagnostic imaging applications. Despite the large interest of using these unique materials as polymer based nanoparticles in biomedical applications, a clear understanding of the cellular uptake ...
Kovacs Jozsef - - 2012
Anderson and Dyck claim that the current trend of almost exclusively using citation-based evaluative metrics to assess the research output of scholars is unsound. I agree with them in this, but I feel that, for practical reasons, this system will not disappear in the near future, so we must concentrate ...
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