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Dorniak-Wall Taisa - - 2012
BACKGROUND: A peripheral intravenous device (PIVD) provides venous access for the administration of medications, blood products and fluids. They can be associated with a risk of infection and other complications, which have prompted the development of evidence-based guidelines for their use at the Royal Adelaide Hospital (RAH). A previous audit ...
Xie Weilong - - 2012
Top cat: [(NHC)Yb{N(SiMe(3) )(2) }(2) ] adducts (NHC=N-heterocyclic carbene) are efficient catalysts for catalytic cross-dehydrogenative coupling of silanes with a range of primary and secondary amines to yield silylamines in high yields (82-100 %) under mild reaction conditions. The catalytic activity and selectivity of the rare-earth-metal silylamides are modulated by altering ...
Kondo Shunsuke - - 2012
In a substantial population of non-small cell lung cancer (NSCLC), expression and activation of EGF receptor (EGFR) have been reported and is regarded as a novel molecular target. A growing body of evidence has shown the signaling crosstalk between EGFR and integrins in cellular migration and invasion. NEDD9 is an ...
Coon Elizabeth A - - 2012
Our objective was to characterize the motor neuron disease features within a large c9FTD/ALS kindred. We analyzed clinical, electrophysiologic and neuropathologic data in a c9FTD/ALS kindred of Scandinavian ancestry. Results showed that of six family members affected, three had only ALS, two had FTD and one had FTD and ALS. ...
Crogan Neva L - - 2012
Background: This article describes the testing of a new nursing home food delivery system that empowers elders to choose the foods they want to eat and gives them an active voice in menu development. Methods: Using a 2-group, repeated measures design, 61 elderly residents from 2 eastern Washington nursing homes ...
Pradelli Lorenzo - - 2012
ABSTRACT: INTRODUCTION: Previous studies and a meta-analysis in surgical patients indicate that supplementing parenteral nutrition regimens with n-3 polyunsaturated fatty acids (PUFAs), in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is associated with improved laboratory and clinical outcomes in the setting of hyper-inflammatory conditions. Refined or synthetic fish oils ...
Steinmetz Heinrich - - 2012
The gliding bacterium Sandaracinus amylolyticus, strain NOSO-4T, was recently characterized as the first representative of a new myxobacterial genus. A screening of the culture broth for antibiotically active metabolites followed by isolation and characterization revealed two unique 3-formylindol derivatives, indiacen A (1) and its chloro derivative indiacen B (2). Both ...
Manickam Gowri - - 2012
Silver thin films are well known as the most sensitive material for surface plasmon resonance (SPR) based analysis. However, the use of silver for this purpose is limited by three main issues, namely poor adhesion to plastic substrates, chemical instability in both air and aqueous environments and hence the difficulty ...
Jahnukainen Kirsi - - 2012
Context:Rapid progress in fertility preservation strategies has led to the investigation of ways in which fertile gametes could be generated from cryopreserved immature testicular tissue. Childhood cancer patients remain the major group that can benefit from these techniques. Other potential candidates include patients undergoing gonadectomy and patients with Klinefelter's syndrome ...
Hofmann A - - 2012
BACKGROUND: Balancing treatment benefits and risks is part of a shared decision-making process before initiating any treatment in multiple sclerosis (MS). Patients understand, appreciate and profit from evidence-based patient information (EBPI). While these processes are well known, long-term risk awareness and risk processing of patients has not been studied. Mitoxantrone ...
Berl Tomas - - 2012
Hyponatremia is the most common electrolyte disorder. With the aging of the population and the greater propensity of the elderly to develop hyponatremia, this electrolyte disorder is of increasing importance to the practicing nephrologist. In this Attending Rounds, an illustrative patient with hyponatremia is presented. The reasons for the increased ...
Kang Soonchul - - 2012
The reaction of Co(NO(3))(2)·6H(2)O and 3-benzoylpyridine with the low-spin iron(iii) complex, H[Fe(III)(phen)(CN)(4)], in methanol gives rise to a cyanide-bridged heterobimetallic chain [{Fe(III)(phen)(CN)(4)}(2)Co(II)(3-bpe)(2)] () that exhibits intrachain ferromagnetic coupling and slow double magnetic relaxation.
Cheng Jiongjia J Department of Chemistry, Boston College, Chestnut Hill, MA 02467, - - 2012
Bacterial phosphatidylinositol-specific phospholipase C targets PI and glycosylphosphatidylinositol-linked proteins of eukaryotic cells. Functional relevance of a homodimeric S. aureus PI-PLC crystal structure is supported by enzyme kinetics and mutagenesis. Nonsubstrate phosphatidylcholine increases activity by facilitating enzyme dimerization. Activating transient dimerization is antagonized by anions binding to a discrete site. Interplay ...
Kawai Hiroyuki - - 2012
The regioselective synthesis of pyrazole triflones has been achieved by 1,3-dipolar cycloaddition of triflyl alkynes and hydrazonoyl chloride in the presence of Hünig's base. Pyrazolo[5,1-a]isoquinoline triflones were also regioselectively synthesized for the first time via tandem 1,3-dipolar cycloaddition/oxidative aromatization between triflyl alkynes and C,N-cyclic azomethine imines.
Gründel Marianne - - 2012
The biosynthesis of glycogen or starch is a main strategy developed by living organisms for the intracellular storage of carbon and energy. In phototrophic organisms, such polyglucans accumulate due to carbon fixation during photosynthesis and are used to provide maintenance energy for cell integrity, function and viability in dark periods. ...
Akuta Norio - - 2012
Objective: Anticarcinogenic activity of ribavirin combination therapy for hepatitis C virus (HCV)-related compensated cirrhosis is still unclear. Methods: In study 1, in 157 consecutive patients with HCV-related compensated cirrhosis, treatment efficacy with interferon plus ribavirin therapy was evaluated for 48 weeks of HCV genotype 1b (HCV-1b) or 24 weeks of ...
Cook Denham G - - 2012
It was hypothesized that chronic hypoxia acclimation (preconditioning) would alter the behavioural low O(2) avoidance strategy of fish as a result of both aerobic and anaerobic physiological adaptations. Avoidance and physiological responses of juvenile snapper (Pagrus auratus) were therefore investigated following a 6 week period of moderate hypoxia exposure (10.2-12.1 ...
Eriksson Christina - - 2012
Abstract Objective:The aim of this study was to describe occupational therapists' expectations and experiences of integrating a new intervention programme within an RCT pilot study, in collaboration with a researcher. Methods:Six occupational therapists participated in a five-day training course (during a one-month period) including lectures, reading articles, and discussions. The ...
Minh Hoangdo - - 2012
Abstract Radical prostatectomy remains the gold-standard surgical treatment for clinically localized prostate cancer. Contrast imaging of the upper urinary tract is not part of the routine work-up of the patient before radical prostatectomy. This may lead to rare, albeit serious complications when anatomical anomalies are present. This article reports a ...
Robilotto Thomas J - - 2012
Isolobal and isolatable: A triangular [L(3) Au(3) ](+) ion, bearing N-heterocyclic carbene ligands (L), is crystallographically characterized (see structure; Au yellow, C gray, N blue). Density functional theory suggests full valence delocalization among the gold atoms, with the HOMO composed largely of gold 6s orbitals and the LUMO comprising a ...
Haddad Gabrielle L GL Department of Chemistry, Lehigh University, Bethlehem, PA 18015, - - 2012
A series of inhibitors of acetylcholinesterase (AChE) have been screened by back-scattering interferometry (BSI). Enzyme levels as low as 100 pM (22,000 molecules of AChE) can be detected. This method can be used to screen for mixed AChE inhibitors, agents that have shown high efficacy against Alzheimer's disease, by detecting dual-binding interactions. ...
Malkani Samir - - 2012
OBJECTIVE: Point of Care (POC) Hemoglobin A1C (A1C) testing allows for timely treatment changes, improved glycemic control and patient and provider satisfaction. Substantial variation between POC and laboratory A1C results has been reported. At our university hospital diabetes clinic, we observed significant negative bias in A1C with the DCA Vantage(™) ...
Esmail Laura C - - 2012
Purpose:Prioritization of translational research on genomic tests is critically important given the rapid pace of innovation in genomics. The goal of this study was to evaluate a stakeholder-informed priority-setting framework in cancer genomics.Methods:An external stakeholder advisory group including patients/consumers, payers, clinicians, and test developers used a modified Delphi approach to ...
Meier Robert - - 2012
Organic solar cells (OSCs) have attracted extensive attention as a promising approach for cost-effective photovoltaic devices. This study demonstrates a novel imprinting approach based on additional plasticizing, which is suited for thin polyethylenedioxythiophene:polystyrenesulphonate (PEDOT:PSS) layers. Such films are widely used as electron blocking and hole collecting intermediate layers in OSCs. ...
Doherty Matthew T MT Molecular Biology Institute and the Department of Biology, San Diego State University, San Diego, California 92182-1030, - - 2012
Myb repeats ∼52 amino acid residues in length were first characterized in the oncogenic Myb transcription factor, which contains three tandem Myb repeats in its DNA-binding domain. Proteins of this family normally contain either one, two, or three tandem Myb repeats that are involved in protein-DNA interactions. The small nuclear ...
Davies Jonathan - - 2012
Abstract Objectives: Small for gestational age (SGA) premature infants are at increased risk for complications. We aimed to evaluate if SGA infants are at higher risk for presenting renal insufficiency in the newborn period compared to appropriate for gestational age (AGA) premature infants. Methods: We conducted a retrospective case-control study ...
Osman Dani - - 2012
The Janus Kinase (JAK) Signal Transducer and Activator of Transcription (STAT) pathway is involved in the regulation of Intestinal Stem Cell (ISC) activity to ensure a continuous renewal of the adult Drosophila midgut. Three ligands, Unpaired1, 2 and 3 are known to activate the JAK/STAT pathway in Drosophila. Using newly ...
Luef Birgit B Department of Earth and Planetary Science, University of California, Berkeley, Berkeley, CA 94720, - - 2013
Iron-reducing bacteria (FeRB) play key roles in anaerobic metal and carbon cycling and carry out biogeochemical transformations that can be harnessed for environmental bioremediation. A subset of FeRB require direct contact with Fe(III)-bearing minerals for dissimilatory growth, yet these bacteria must move between mineral particles. Furthermore, they proliferate in planktonic ...
Casal Charliana - - 2012
OBJECTIVES: To investigate the risk factors for infection and the outcome of pregnancy in women diagnosed with syphilis using a molecular approach. METHODS: Case-control study of pregnant women admitted to a maternity ward, with the cases classified as early or latent maternal syphilis, based on clinical-serological diagnoses. The DNA of ...
Shabsigh Ridwan - - 2012
Introduction.  Tadalafil is efficacious and well tolerated for erectile dysfunction (ED), but effects in men with "complete ED" are unclear. Aim.  To investigate effects of once-daily tadalafil in men with no successful intercourse attempts at baseline. Methods.  Through a post hoc, pooled-data analysis of four randomized, double-blind trials on the ...
Farnaby Joy H - - 2012
The reaction chemistry of the side-on bound (N(2))(2-), (N(2))(3-), and (NO)(2-) complexes of the [(R(2)N)(2)Y](+) cation (R = SiMe(3)), namely, [(R(2)N)(2)(THF)Y](2)(μ-η(2):η(2)-N(2)), 1, [(R(2)N)(2)(THF)Y](2)(μ-η(2):η(2)-N(2))K, 2, and [(R(2)N)(2)(THF)Y](2)(μ-η(2):η(2)-NO), 3, with oxidizing agents has been explored to search for other (E(2))(n-), (E = N, O), species that can be stabilized by this cation. ...
Anderson Eloy Jean - - 2012
BACKGROUND: Successful reconstruction of large anterior skull base (ASB) defects after craniofacial resection of malignant skull base tumors is paramount for preventing cerebrospinal fluid (CSF) fistulas. The vascularized pedicled pericranial flap (PCF) has been the gold standard for repairing ASB defects after transbasal transcranial approaches. However, flap necrosis and delayed ...
Tavares L - - 2012
Here, we report localized, polarized and waveguided electroluminescence (EL) from well aligned organic nanofibres integrated via roll printing on transistor platforms. The localized emission is due to the application of an alternating current voltage to the transistor gate electrodes, which causes sequential injection of holes and electrons into the organic ...
Barker David J P - - 2012
Context: Memorial to Jim Tanner. Objective: To examine the links between early growth and chronic disease in later life. Methods: Literature review. Results: There is now a developmental model for the origins of chronic disease in which the causes to be identified are linked to normal variations in feto-placental, infant ...
Marras Theodore K - - 2012
SUMMARY AT A GLANCE: We evaluated CT features, symptoms and microbiological disease criteria in pulmonary Mycobacterium xenopi. Cavitation and large nodules were associated with microbiologic criteria for disease. Bronchiectasis and small nodules were associated with symptoms. Cavitation and large nodules should be considered as being supportive for early initiation of ...
Solovyov Leonid A - - 2012
Ordered mesostructured mesoporous materials, combining nano-organization with atomic disorder, are both attractive and challenging objects of investigation by X-ray and neutron diffraction. The development of diffraction mesostructure analysis methods and their applications in studies on structural characterization, formation processes and physisorption phenomena in these advanced materials are summarized in this ...
Otto-Hanson Lindsey K - - 2012
Success in biological control of plant diseases remains inconsistent in the field. A collection of well- characterized Streptomyces antagonists (n=19 isolates) was tested for their capacities to inhibit pathogenic Streptomyces scabies (n=15 isolates). There was significant variation among antagonists in ability to inhibit pathogen isolates and among pathogens in their ...
O'Flynn Neil M J - - 2012
The insect baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) enters many mammalian cell lines, prompting its application as a general eukaryotic gene delivery agent, but the basis of entry is poorly understood. For adherent mammalian cells we show that entry is favoured by low pH and increasing the available ...
Shaw Kathryn D - - 2012
BACKGROUND AND PURPOSE: Physiotherapy services provided outside of business hours may improve patient and hospital outcomes, but there is limited understanding of what services are provided. This study described current services provided outside of business hours across Australian hospitals. METHODS: Design Descriptive, cross-sectional, Web-based survey. Participants A random sample of ...
Semprini Gabriele - - 2012
ABSTRACT The authors' aim was to compare interhemispheric transfer time between 2 groups: highly skilled sportsmen and control subjects. Left- and right-handed individuals were included in the study. The Poffenberger paradigm was used to measure the crossed-uncrossed difference, representing the time to transfer information from one hemisphere to the other. ...
Verbrugge Frederik Hendrik - - 2012
OBJECTIVE: To investigate whether time from onset of heart failure signs and/or symptoms (ie, progression to stage C/D heart failure) until implantation affects reverse remodelling and clinical outcome after cardiac resynchronisation therapy (CRT). DESIGN: Cohort study of consecutive CRT patients, implanted between 1 October 2008 and 30 April 2011. SETTING: ...
Bobick Brent E - - 2012
In humans, loss of SHOX gene function is responsible for the mesomelic short stature characteristic of Turner syndrome, Leri-Weill dyschondrosteosis, and Langer dysplasia. In a mouse model of SHOX deficiency, Prrx1-Cre-driven limb-specific deletion of the paralogous gene Shox2 results in severe rhizomelia. In this study, we show that Col2a1-Cre-driven deletion ...
Linehan W Marston - - 2012
Kidney cancer is not a single disease; it is made up of a number of different types of cancer, including clear cell, type 1 papillary, type 2 papillary, chromophobe, TFE3, TFEB, and oncocytoma. Sporadic, nonfamilial kidney cancer includes clear cell kidney cancer (75%), type 1 papillary kidney cancer (10%), papillary ...
Wosnitza Anne - - 2012
Legged locomotion is the most common behavior of terrestrial animals and it is assumed to have become highly optimized during evolution. Quadrupeds, for instance, use distinct gaits which are optimal with regard to metabolic cost and have characteristic kinematic features and patterns of inter-leg coordination. In insects, the situation is ...
Humenny William J - - 2012
Ring the changes: The cycloaddition of nitrones with 1-carboallyloxy-1-carbomethoxycyclopropanes yields tetrahydro-1,2-oxazines, which in turn undergo a Tsuji dehydrocarbonylation to give dihydro-1,2-oxazines (see scheme; dba=dibenzylideneacetone). Addition of base to this reaction mixture results in clean conversion to pyrroles. The result is a flexible three-component strategy for the synthesis of tetrasubstituted pyrroles.
Sehn Francisléa - - 2012
Objective.  Catastrophizing is a maladaptive response to pain and is one of the factors that contribute to the chronicity of some pain syndromes. The Pain Catastrophizing Scale (PCS) assists both treatment planning and outcome assessment. Its use is limited in Portuguese-speaking countries because of the lack of a validated translated ...
Dieteren Cindy E J CE Department of Biochemistry, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The - - 2012
Studies employing native PAGE suggest that most nDNA-encoded CI subunits form subassemblies before assembling into holo-CI. In addition, in vitro evidence suggests that some subunits can directly exchange in holo-CI. Presently, data on the kinetics of these two incorporation modes for individual CI subunits during CI maintenance are sparse. Here, ...
Svilar David D Departments of Pharmacology& Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213-1863, - - 2012
To identify genes that contribute to chemotherapy resistance in glioblastoma, we conducted a synthetic lethal screen in a chemotherapy-resistant glioblastoma-derived cell line with the clinical alkylator temozolomide (TMZ) and an siRNA library tailored toward "druggable" targets. Select DNA repair genes in the screen were validated independently, confirming the DNA glycosylases ...
Kim Joon Bum - - 2012
BACKGROUND: Although recent studies contributed to an improved understanding of the prognosis of patients undergoing tricuspid valve (TV) surgery, the data are limited to certain causes of tricuspid regurgitation (TR) or types of surgery. OBJECTIVE: This study aimed to identify predictors of clinical outcomes of patients undergoing TV surgery for ...
Clarsen Benjamin - - 2012
BACKGROUND: Current methods for injury registration in sports injury epidemiology studies may substantially underestimate the true burden of overuse injuries due to a reliance on time-loss injury definitions. OBJECTIVE: To develop and validate a new method for the registration of overuse injuries in sports. METHODS: A new method, including a ...
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