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Serisier Dj - - 2012
SUMMARY AT A GLANCE: Australasian emergency and respiratory physicians infrequently use the Pneumonia Severity Index (PSI) and are unable to apply it accurately. Two physician groups differed in their relative abilities to apply PSI and CURB65, suggesting fragmented guideline dissemination. Australasian guidelines should promote a simple, coordinated pneumonia severity assessment ...
Menezes Cn - - 2012
OBJECTIVES: Stavudine is being phased out because of its mitochondrial toxicity and tenofovir (TDF) is recommended as part of first-line highly active antiretroviral therapy (HAART) in South Africa. A prospective, open-label, randomized controlled trial comparing standard- and low-dose stavudine with TDF was performed to assess early differences in adipocyte mtDNA ...
Deasy Conor - - 2012
AIM: We describe improved reporting of paediatric out-of-hospital cardiac arrest (OHCA) by adding coronial findings to a cardiac arrest registry. METHODS: Non-traumatic OHCA occurring in paediatric patients aged less than 16 years were identified using the Victorian Ambulance Cardiac Arrest Registry and available coronial findings reviewed. RESULTS: Between the years ...
Stewart Mark G - - 2012
We evaluate, for the U.S. case, the costs and benefits of three security measures designed to reduce the likelihood of a direct replication of the 9/11 terrorist attacks. To do so, we assess risk reduction, losses, and security costs in the context of the full set of security layers. The ...
De Jaco Antonella - - 2012
The α/β-hydrolase fold super-family of proteins is composed of structurally related members that, despite great diversity in their catalytic, recognition, adhesion and chaperone functions, share a common fold governed by homologous residues and conserved disulfide bridges. Non-synonymous single nucleotide polymorphisms, within the α/β-hydrolase fold domain, in different family members have ...
Hinchcliff Reece - - 2012
AIMS: To systematically identify and synthesise health service accreditation literature. METHODS: A systematic identification and narrative synthesis of health service accreditation literature published prior to 2012 were conducted. The search identified 122 empirical studies that examined either the processes or impacts of accreditation programmes. Study components were recorded, including: dates ...
Busby Ben - - 2012
Facultative pathogens have extremely dynamic pan-genomes, to a large extent derived from bacteriophages and other mobile elements. We developed a simple approach to identify phage-derived genomic islands and apply it to show that pathogens from diverse bacterial genera are significantly enriched in clustered phage-derived genes compared with related benign strains. ...
Groll Klaus - - 2012
A handsome couple: Through the use of the simple Pd catalyst [Pd(tmpp)(2) Cl(2) ] (tmpp=tris(2,4,6-trimethoxyphenyl)phosphine) and THF/DMF as solvent, various aryl-, heteroaryl-, benzyl- and alkylaluminum reagents can be readily cross-coupled with aryl or heteroaryl iodides, bromides, and nonaflates, and in special cases even with chlorides and triflates. This cross-coupling tolerates ...
Urrets-Zavalia Julio A - - 2012
AIMS: To assess the impact of different oxygenation policies on the rate and severity of retinopathy of prematurity (ROP). METHODS: Between January 2003 and December 2006, infants of 1500 g birthweight (BW) or less and/or 32 weeks gestational age (GA) or less, and larger, more mature infants with risk factors ...
Wan Jun - - 2012
Water scarcity has become a constraint for regional economic development in many cities and regions. Water rationing serves as one instrument to constrain water consumption to persuade users to save water and to moderate their consumption. When the supply of water is unable to satisfy demand, a loss of welfare ...
Lopci Egesta - - 2012
Abstract Aim: To verify the potential role and feasibility of carbidopa premedication in pediatric patients undergoing (18)F-DOPA (Fluorine-18 fluorodihydroxyphenylalanine) PET scanning. Materials and Methods: For this limited study, 5 patients (M:F=3:2; mean age 4.8 years) with a positive history for neuroblastoma who had been referred to our institution for instrumental ...
Bourcet Emmanuel - - 2012
The total synthesis of plakotenin, a cytotoxic marine natural product, using a biomimetic Diels-Alder reaction is described in detail. Two approaches were used, whereby the Diels-Alder reaction occurs at different stages of the synthesis. Homo- and nor-plakotenin, related natural products, were also prepared, as well as iso-plakotenin, a diastereoisomer of ...
Boddi Valentina - - 2012
Introduction.  The relational domain of erectile dysfunction (ED) is difficult to investigate in a clinical setting. We developed and validated SIEDY, a 13-item structured interview, that evaluates, besides the organic (Scale 1) and intra-psychic (Scale 3) domains, also the relational one (Scale 2). We previously established a pathological threshold for ...
van der Werf Christine S - - 2012
Purpose:Autosomal recessive congenital short bowel syndrome is caused by mutations in CLMP. No mutations were found in the affected males of a family with presumed X-linked congenital short bowel syndrome or in an isolated male patient. Our aim was to identify the disease-causing mutation in these patients.Methods:We performed mutation analysis ...
Tay Jun H - - 2012
SUMMARY AT A GLANCE: This study demonstrates that visualization of peripheral lung lesions by endobronchial ultrasound (EBUS) is significantly influenced by lesion size, malignancy status and distance from hilum to lesion. Emphasis on those factors should lead to increased EBUS diagnostic yield. ABSTRACT: Background and study objective:   Endobronchial ultrasound ...
Jiang Deng-Jin - - 2012
BACKGROUND: The importance of basic surgical skills is entirely agreed among surgical educators. However, restricted by ethical issues, finance etc, the basic surgical skills training is increasingly challenged. Increasing cost gives an impetus to the development of cost-effective training models to meet the trainees' acquisition of basic surgical skills. In ...
Ansari Shamshul - - 2012
Diarrheal diseases are major problem of developing countries. Though precise data on childhood mortality associated with diarrheal diseases in Nepal is not available, it has been estimated that approximately 25% of child death are associated with diarrheal disease, particularly acute diarrhea. The purpose of this study was to assess the ...
Coleman Mary Clayton - - 2012
In his classic paper, 'Why abortion is immoral', Don Marquis argues that what makes killing an adult seriously immoral is that it deprives the victim of the valuable future he/she would have otherwise had. Moreover, Marquis contends, because abortion deprives a fetus of the very same thing, aborting a fetus ...
Akin Ibrahim I - - 2012
ABSTRACT: BACKGROUND: Transcatheter aortic valve implantation (TAVI) has been established as a treatment option for inoperable patients with symptomatic aortic valve stenosis. However, patients suffer frequently from conduction disturbances after TAVI. METHODS: Baseline, procedural as well as surface and intracardiac ECG parameters were evaluated for patients treated with TAVI and ...
Park Jung Hyo - - 2012
We report a new recipe to synthesize heterogeneous catalyst arrays using the space specificity of an embodied micelle. Also, SEM, AFM, STEM, and TXRF analyses prove that these catalysts are of exposed core-shell types. Furthermore, their structures were found to allow the design of a high performance photocatalyst for water ...
Furze Jennifer - - 2012
Background and purpose: Clinical reasoning is a core tenet of physical therapy practice leading to optimal patient care. The purpose of this case was to describe the outcomes, subjective experience, and reflective clinical reasoning process for a child with cerebral palsy using the International Classification of Functioning, Disability, and Health ...
Leitao D C - - 2012
The introduction of voids in a magnetic thin-film alters the stray field distribution and enables the tailoring of the corresponding physical properties. Here we present a detailed study on thin magnetic nanohole arrays (NhAs) grown on top of hexagonally-ordered anodic aluminum oxide (AAO) substrates. We address the effect of AAO ...
Pifl Christian - - 2012
The thalamus occupies a pivotal position within the corticobasal ganglia-cortical circuits. In Parkinson's disease (PD), the thalamus exhibits pathological neuronal discharge patterns, foremost increased bursting and oscillatory activity, which are thought to perturb the faithful transfer of basal ganglia impulse flow to the cortex. Analogous abnormal thalamic discharge patterns develop ...
Mukaeda Yuki - - 2012
The Kobayashi aldol reaction is one of the most powerful methods to synthesize the polyketide skeleton and has been applied to the total synthesis of natural products. This methodology has been used to construct anti-aldol products, and only a few precedents on the syn-selective Kobayashi aldol reaction are known. A ...
Park Seong Bin - - 2012
ABSTRACT: Edwardsiella tarda is one of the serious fish pathogens, infecting both cultured and wild fish species. Research on edwardsiellosis has revealed that E. tarda has a broad host range and geographic distribution, and contains important virulence factors that enhance bacterial survival and pathogenesis in hosts. Although recent progress in ...
Hayashi Yugo - - 2012
Oxidized horse cytochorme c (cyt c) has been shown to oligmerize by domain swapping its C-terminal helix successively. We show that the structural and thermodynamic properties of dimeric Hydrogenobacter thermophilus (HT) cytochrome c(552) (cyt c(552)) and dimeric horse cyt c are different, although both proteins belong to the cyt c ...
Huang Shaobai - - 2012
Mitochondria complex II (succinate dehydrogenase, SDH) plays a central role in respiratory metabolism as a component of both the electron transport chain and the tricarboxylic acid cycle. We report the identification of an SDH assembly factor by analysis of T-DNA insertions in At5g51040, a protein with unknown function that was ...
Hoffman Martin D - - 2012
Abstract This study examined whether urine dipstick testing might be useful to predict the development of acute kidney injury after an ultramarathon. Participants in the 2011 161-km Western States Endurance Run underwent post-race blood and urine dipstick analyses. Of the 310 race finishers, post-race urine dipstick testing was completed on ...
Bartalena L - - 2012
Background:Optimal doses of iv glucocorticoids for Graves' orbitopathy (GO) are undefined.Methods:We carried out a multicenter, randomized, double-blind trial to determine efficacy and safety of three doses of iv methylprednisolone in 159 patients with moderate to severe and active GO. Patients were randomized to receive a cumulative dose of 2.25, 4.98, ...
Sepúlveda María - - 2012
OBJECTIVE: The aim of this study is to report the clinical profile and outcome of longitudinally extensive transverse myelitis (LETM). METHODS: We prospectively studied adult patients who presented with LETM from January 2008 to December 2011. Information on demographic, clinical course, magnetic resonance imaging (MRI) and outcome was collected. HLA-DRB1 ...
Lin Xiao-Ming - - 2012
Assembly of Zn(NO(3) )(2) with the tripodal ligand H(3) TCPB (1,3,5-tri(4-carboxyphenoxy)benzene) affords two porous isoreticular metal-organic frameworks, [Zn(3) (TCPB)(2) ⋅2DEF]⋅ 3DEF (1) and [Zn(3) (TCPB)(2) ⋅2H(2) O]⋅ 2H(2) O⋅4DMF (2). Single-crystal X-ray diffraction analyses reveal that 1 crystallizes in the monoclinic space group P2(1) /c and possesses a 2D network ...
Ahmadi Hamed - - 2012
What's known on the subject? and What does the study add? Clinical stage is an integral part of outlining treatment strategy and counselling patients with bladder cancer. The discordance rate between clinical stage and pathological stage, however, is currently high with more than 40% of patients with presumed organ-confined disease ...
Hu Xiao-Bo - - 2012
Three pillar[n]arenes (n = 8-10) were synthesized. X-ray analysis demonstrated that, different from early reported small pillar[n]arenes (n = 5, 6), these larger macrocycles gave rise to two cavities. (1)H NMR and MS experiments revealed that pillar[9]arene complexed one n-octyltrimethyl ammonium in chloroform, while pillar[10]arene could complex two.
Wilson Hannah J - - 2012
Background: Childhood stunting has been associated with an increased risk of obesity in adulthood, but the causes are unclear. This study hypothesizes that stunting significantly reduces both resting and activity energy expenditure. Aim: To assess and describe energy expenditure of low socio-economic Maya children and to determine whether stunting is ...
Di Fiore Juliann M - - 2012
Background:We have previously shown an increased incidence of intermittent hypoxemic events (IH) in preterm infants with severe retinopathy of prematurity (ROP). Animal models suggest that patterns of IH events may play a role in ROP severity as well. We hypothesize that specific IH patterns are associated with ROP in preterm ...
Khosla Divya - - 2012
Astroblastoma is a rare glial tumor with uncertain histopathological origin and unpredictable clinical behavior. We present a case of an 11-year-old girl who presented with headache and blurring of vision for 2 months. A well-demarcated mass was found in the right frontoparietal lobe on a brain MRI. The patient was ...
Becker Dominic - - 2012
The Ireland-Claisen rearrangement is the central step in the synthesis of tubuphenylalanine, a key building block of the highly antitumor-active tubulysins. The rearrangement of substituted β-amino acid allyl esters, in combination with subsequent decarboxylation and oxidative cleavage of the double bond, allows the highly stereoselective introduction of substituents into the ...
Wu Gang - - 2012
In this work, we present a synthesis approach for nitrogen-doped graphene-sheet-like nanostructures via the graphitization of a heteroatom polymer, in particular polyaniline, under the catalysis of a cobalt species using multi-walled carbon nanotubes (MWNTs) as a supporting template. The graphene-rich composite catalysts (Co-N-MWNTs) exhibit substantially improved activity for oxygen reduction ...
Malmeström Clas - - 2012
BACKGROUND: Recently, a polymorphism in the LIGHT gene was shown to increase the risk of multiple sclerosis (MS) in a genome-wide association study (GWAS). OBJECTIVE: Our aim was to investigate if serum levels of LIGHT were affected by this polymorphism and by the disease itself. METHODS: Serum levels of LIGHT ...
Yoh Kousei - - 2012
Abstract Objective: To assess changes in quality of life (QOL) and pain in raloxifene-treated Japanese women with postmenopausal osteoporosis. Research Design and Methods: This prospective, postmarketing observational study was conducted at 60 Japanese hospitals from September 2007 to February 2009 and included Japanese women with postmenopausal osteoporosis who were new ...
Fabri Rodrigo L - - 2012
The bioactivity guided fractionation of the dichloromethane extract of Mitracarpus frigidus afforded the pyranonaphthoquinone psychorubrin. This compound, hitherto unknown in the genus Mitracarpus, had its biological activity evaluated against one panel of bacteria and two fungi, three tumor cell lines (HL60, Jurkat and MCF-7) and four Leishmania species. Its identity ...
Kumar Vinod - - 2012
Rock-salt-based honeycomb structures containing Te(VI) and Sb(V) with innumerable prospects of properties and applications were realized in the two new series of mixed-metal oxides of lithium, Li(8)M(2)Te(2)O(12) (M(II) = Co, Ni, Cu, Zn) and Li(8)M(2)Sb(2)O(12) (M(III) = Cr, Fe, Al, Ga). The structures of Li(8)Co(2)Te(2)O(12) and Li(8)Cu(2)Te(2)O(12) were determined by ...
Helal Imed - - 2012
Background: This study evaluates the prevalence of cardiovascular events in autosomal dominant polycystic kidney disease (ADPKD) patients. Methods: We distributed surveys to 1,439 subjects from our ADPKD research database. In total, 426 subjects completed and returned surveys; 7 of these were from children and were excluded from the study. Results: ...
Kostikov Alexey P - - 2012
N-Succinimidyl 3-(di-tert-butyl[(18)F]fluorosilyl)benzoate ([(18)F]SiFB) is a highly reactive prosthetic group for radiolabeling of proteins for use in positron emission tomography (PET). It is similar to N-succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB), the 'gold-standard' prosthetic group for protein (18)F-labeling, but can be synthesized using a much shorter and technically easier procedure. A recently reported simple procedure ...
Marks Sebastian - - 2012
The divalent lanthanide borohydrides [Ln(BH(4))(2)(THF)(2)] (Ln = Eu, Yb) have been prepared in a straightforward approach. The europium compound shows blue luminescence in the solid state, having a quantum yield of 75%. Nonradiative deactivation of C-H and B-H oscillator groups could be excluded in the perdeuterated complex [Eu(BD(4))(2)(d(8)-THF)(2)], which showed ...
Fancello Laura - - 2012
Here, we present the first metagenomic study of viral communities from four perennial ponds (gueltas) located in the central Sahara (Mauritania). Three of the four gueltas (Ilij, Molomhar and Hamdoun) are located at the source of three different wadis belonging to the same hydrologic basin, whereas the fourth (El Berbera) ...
Dowd W Wesley - - 2012
Coping with environmental stress may involve combinations of behavioral and physiological responses. We examined potential interactions between adult mussels' simple behavioral repertoire - opening/closing of the shell valves - and thermal stress physiology in common-gardened individuals of three Mytilus congeners found on the West Coast of North America, two of ...
Neat Michael J - - 2012
Fluorescence in situ hybridisation (FISH) analysis is now widely employed in the diagnosis and risk stratification of a wide range of malignant diseases. While this technique is used successfully with formalin-fixed paraffin-embedded (FFPE) sections from numerous tissue types, FISH analysis of FFPE tissue sections from trephine biopsy specimens has been ...
Biegus Jan - - 2012
INTRODUCTION Acute heart failure (AHF) is associated with multiorgan dysfunction which unfavorably affects prognosis.  OBJECTIVES We investigated the prevalence, determinants and prognostic consequences of abnormal liver function tests (LFTs) in AHF population.  PATIENTS AND METHODS Retrospective analysis of AHF patients with LFTs (serum bilirubin, AST [Aspartate aminotransferase], ALT [Alanine Aminotransferase] and albumin) on ...
Vargovic Peter - - 2012
Catecholamines (CATs), the major regulator of lipolysis in adipose tissue, are produced mainly by the sympathoadrenal system (SAS). However, recent studies report endogenous CAT production in adipocytes themselves. This study investigated the effects of single and repeated (7 to 14 times) immobilization (IMO) stress on CAT production in various fat ...
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