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Results 201 - 250 of 2845
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Noël Christopher R - - 2012
Two-partner secretion (TPS) systems use β-barrel proteins of the Omp85-TpsB superfamily to transport large exoproteins across the outer membranes of Gram-negative bacteria. The Bordetella FHA/FhaC proteins are prototypical of TPS systems in which the exoprotein contains a large C-terminal prodomain that is removed during translocation. Although it is known that ...
Eisenberg Tobias - - 2012
A wild badger (Meles meles) with a severe nodular dermatitis was presented for post mortem examination. Numerous cutaneous granulomas with superficial ulceration were present especially on head, dorsum, and forearms were found at necropsy. Histopathological examination of the skin revealed a severe granulomatous dermatitis with abundant intralesional round to spherical ...
Banwo Kolawole - - 2012
AIM: To identify enterococci from the fermentation of milk for the production of nono, an African fermented dairy product, to determine the technological properties for suitability as starter cultures and safety as probiotics. METHODS AND RESULTS: Enterococcus faecium CM4 and Enterococcus faecium 2CM1, were isolated from raw cow's milk. The ...
Trujillo M A - - 2012
The sodium-iodide symporter (NIS) directs the uptake and concentration of iodide in thyroid cells. We have extended the use of NIS-mediated radioiodine therapy to prostate cancer. We have developed a prostate tumor specific conditionally replicating adenovirus that expresses hNIS (Ad5PB_RSV-NIS). For radiovirotherapy to be effective in humans, the radioiodine dose ...
Obeng-Adjei N - - 2012
The prevalence of hepatitis B virus (HBV) infection in Asia and sub-Sahara Africa is alarming. With quarter of a billion people chronically infected worldwide and at risk of developing liver cancer, the need for a prophylactic or therapeutic vaccination approach that can effectively induce protective responses against the different genotypes ...
Forester Sarah C - - 2012
Green tea has been shown to ameliorate symptoms of metabolic syndrome in vivo. The effects could be due, in part, to modulation of postprandial blood glucose levels. We examined the effect of coadministration of (-)-epigallocatechin-3-gallate (EGCG, 100 mg/kg, i.g.) on blood glucose levels following oral administration of common corn starch ...
Xiao Bo - - 2012
Inflammatory bowel disease (IBD) is a chronic relapsing idiopathic disease. In clinical terms, most patients require lifelong medication associated with possible unpleasant adverse effects. Oral colon-specific drug delivery systems are designed to deliver therapeutic drugs to the inflamed colon to target pathophysiological manifestations of IBD. The aim is to maintain ...
Hafsteinsdóttir Thóra B - - 2013
To determine the feasibility of the Clinical Nursing Rehabilitation Stroke-guideline (CNRS-guideline) in the care of stroke patients in terms of the experiences, views and attitudes of nurses towards the guideline and their adoption of the guideline and how often the recommendations were used. A four phase cross sectional design was ...
Combs Stephanie A - - 2013
The purposes of this mixed-methods study were to (1) investigate whether walking faster or walking farther was more important for getting "out and about" to persons with chronic stroke and (2) explore explanations for walking preferences. A convenience sample of 77 adults with chronic stroke completed questionnaires and walking outcomes ...
Lee J - - 2012
To investigate the characteristics of patients with a localized retinal nerve fiber layer (RNFL) defect and normal optic disc appearance compared with normal tension glaucoma (NTG) patients. A total of 40 patients with an unchanged RNFL defect for more than 5 years and normal optic disc appearance, who were presumed ...
Inoue K - - 2012
We investigated the appearance frequency of eyelid pigmentation and eyelash bristles after the use of five types of prostaglandin (PG) analogs. This study included 250 eyes from 250 patients diagnosed with primary open-angle glaucoma or ocular hypertension who were treated with either latanoprost, travoprost, tafluprost, bimatoprost, or isopropyl unoprostone for ...
Abbaoui Besma B The Ohio State University, Columbus, OH 43210, - - 2012
Epidemiologic evidence suggests diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk. Our objectives are to investigate these observations and determine the role of isothiocyanates in primary or secondary bladder cancer prevention. We initially investigate the mechanisms whereby broccoli and broccoli sprout extracts and pure ...
Yang Chao-Shun CS Program for RNA Biology, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. - - 2013
Induced reprogramming of somatic cells has had a great impact on stem cell research, and the reprogramming technologies have evolved from four transgenic factors (Oct4, Sox2, Klf4, and c-Myc; OSKM) to just a few microRNAs (mainly miR-290/302 seed family). Despite these advances, the molecular events occurring during various stages of ...
Yuan Zhi-Xin ZX Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, - - 2013
Linoleic acid (LA) and LA-esters are the precursors of LA hydroperoxides, which are readily converted to 9- and 13-hydroxy-​octadecadienoic acid (HODE) and 9- and 13-oxo-​octadecadienoic acid (oxo ODE) metabolites in vivo. These four oxidized LA metabolites (OXLAMs) have been implicated in a variety of pathological conditions. Therefore, their accurate measurement ...
Gilbert Gregg H GH Department of Clinical and Community Sciences, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294-0007, USA. - - 2013
Practice-based research networks (PBRNs) provide a venue to foster evidence-based care. We tested the hypothesis that a higher level of participation in a dental PBRN is associated with greater stated change toward evidence-based practice. A total of 565 dental PBRN practitioner-investigators completed a baseline questionnaire entitled 'Assessment of Caries Diagnosis ...
Uno Hajime H Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA. - - 2013
Risk prediction procedures can be quite useful for the patient's treatment selection, prevention strategy, or disease management in evidence-based medicine. Often, potentially important new predictors are available in addition to the conventional markers. The question is how to quantify the improvement from the new markers for prediction of the patient's ...
Jin Kai - - 2012
Fungal biocontrol agents have great potential in integrated pest management. However, poor efficacy and sensitivity to various adverse factors have hampered their wide application. In eukaryotic cells, Hog1 kinase plays a critical role in stress responses. In this study, MaHog1 (GenBank accession number EFY85878), encoding a member of the Hog1/Sty1/p38 ...
Wyndaele Jean-Jacques - - 2012
What's known on the subject? and What does the study add? Clean intermittent catheterization (CIC) is considered the method of choice for bladder emptying when neurological or non-neurological causes make normal voiding impossible or incomplete. The outcome is overall good, also in the long-term. There is neither one best technique ...
Szarek Dariusz - - 2012
In this study, scanning electron microscopy (SEM) has been applied for instantaneous assessment of processes occurring at the site of regenerating nerve. The technique proved to be especially useful when an artificial implant should have been observed but have not yet been extensively investigated before for assessment of nerve tissue. ...
Shakibaie Mojtaba - - 2012
Context: In the present investigation, acute and subacute toxicity of the biogenic Se nanoparticles (Se NPs) has been reported. Objective: To characterize the Se NPs produced by a bacterium species and to evaluate their toxicity and impact on clinical chemistry and hematological parameters of NMRI mice. Materials and methods: The ...
Yan Biao - - 2012
MyoD is one of the helix-loop-helix proteins regulating muscle-specific gene expression in tilapia. Tight regulation of MyoD protein level is necessary for the precise regulation of skeletal muscle development. MicroRNAs (miRNAs) are a class of regulatory RNAs that post-transcriptionally regulate gene expression. Increasing evidences have suggested that miRNAs play an ...
Lipke Mark C - - 2012
Hydridosilicate anions ([ArSiH(4) ](-) and [SiH(6) ](2-) ) were stabilized as ligands in diruthenium SiH σ-complexes [{(PhBP(Ph) (3) )Ru}(2) (μ-Cl)(μ-η(3) ,η(3) -H(4) SiAr)] (Ar=2-MeOC(6) H(4) , Mes, Ph) and [{(PhBP(Ph) (3) )Ru}(2) (μ-η(4) ,η(4) -H(6) Si)]. These complexes were formed under mild conditions and characterized by single-crystal X-ray diffraction, NMR ...
Ray Nicola J - - 2012
Patients with Parkinson's disease (PD) often develop a spectrum of cognitive symptoms that can evolve into dementia. Dopamine (DA) replacement medications, though improving motor symptoms, can exert both positive and negative effects on cognitive ability, depending on the severity of the disease and the specific skill being tested. By considering ...
Grochala Wojciech - - 2012
Elemental helium is a prototypical noble gas and its atom sets the records for many physicochemical properties. With its two electrons in the closed 1s shell, He is the smallest, the least polarizable, the most difficult to ionize, the hardest (in Pearson's sense) and the most electronegative atom known. Helium ...
Modan-Moses Dalit - - 2012
Background:Multiple studies associate low vitamin D levels with cancer morbidity and mortality. However, few studies measured vitamin D in pediatric patients with malignancy. Our aim was to assess vitamin D status in a large cohort of pediatric cancer patients and define risk factors for deficiency.Methods:Circulating 25-hydroxyvitamin D (25OHD) was measured ...
Yan Jin - - 2012
Introduction.  Monogamous female sexually transmitted infection (STI) patients are at high risk of recurrent STI, but there is no study investigating their risk behaviors. Aim.  We investigated the prevalence of male condom use and associated factors among monogamous STI female patients. Main Outcome Measures.  Independent variables included socio-demographic characteristics, STI ...
Rodriguez Patricia A - - 2012
In recent years immense progress has been made towards understanding the functions of effectors from a range of plant pathogens, such as oomycetes, fungi, bacteria, and nematodes. Like plant pathogens, aphids form close associations with host plants, featuring signal exchange between the two organisms. While feeding and probing, aphids deliver ...
Lintermans A - - 2012
BackgroundAromatase inhibitors (AIs) frequently lead to the AI-induced musculoskeletal syndrome (AIMSS). Looking into its pathophysiology, 6 months of AI therapy thickens the tendon sheath with intra-articular fluid (IAF) retention and loss of grip strength. We here report 24-month follow-up data.Patients and methodsA prospective cohort study of 33 postmenopausal breast cancer ...
Yoshimura Satoshi - - 2012
OBJECTIVE: To clarify whether genetic and common infectious backgrounds are distinct, according to anti-aquaporin 4 (AQP4) antibody status in Japanese patients with neuromyelitis optica (NMO). METHODS: We analysed human leucocyte antigen (HLA)-DRB1 and HLA-DPB1 alleles, and IgG antibodies against Helicobacter pylori, Chlamydia pneumoniae, varicella zoster virus and Epstein-Barr virus nuclear ...
Wang Dong-Lai - - 2012
Very recently, two novel Sc(3)NC-based cluster fullerenes Sc(3)NC@C(80) (Wang et. al. J. Am. Chem. Soc. 2010, 132, 16362) and Sc(3)NC@C(78) (Wu et. al. J. Phys. Chem. C 2011, 115, 23755) were prepared and characterized, respectively. Inspired by these findings, the possibility of encapsulating Sc(3)NC cluster in the C(84) fullerene is ...
Neuhausen Alexander Benjamin - - 2012
We present a method to fabricate individually addressable junctions of self-assembled monolayers (SAMs) that builds on previous studies which have shown that soft conductive polymer top contacts virtually eliminate shorts through the SAMs. We demonstrate devices with nanoscale lateral dimensions, representing an order of magnitude reduction in device area, with ...
Niu Qiu-Hong - - 2012
Background: Soil-dwelling Bacillus nematocida B16 can kill Caenorhabditis elegans via a Trojan horse-like mechanism. However, colonization is a key problem that must be solved during the infection process. Aims: To study the molecular mechanism involved in the colonization of B. nematocida B16 against the host C. elegans. Methods: GFP-expressing strain ...
Tecchio Cristina - - 2012
Abstract We assessed the retrospective applicability and prognostic value of the National Institutes of Health (NIH) classification of chronic GVHD (cGVHD) in 159 consecutive patients after allogeneic hematopoietic stem cell transplant (HSCT). Seventy-four patients (46.5%) resulted affected by late-acute GVHD (n=19; 25.7%), classic cGVHD (n= 44; 59.4%) and overlap syndrome ...
Laurin-Lemay S - - 2012
Anthropogenic range expansion and cultural practices have modified the distribution, abundance and genetic diversity of domesticated organisms, thereby altering multitrophic assemblages through space and time. The putative Mesoamerican domestication centre of the common bean, Phaseolus vulgaris L., in Mexico allows investigating the effects of plant domestication on the genetic structure ...
Zhang Fan - - 2012
The PALB2 protein is associated with breast cancer susceptibility and Fanconi anemia. Notably, PALB2 is also required for DNA repair by homologous recombination (HR). The mechanisms that regulate PALB2, and the functional significance of its interaction with the BRCA1 breast cancer susceptibility protein, are poorly understood, however. Here, to better ...
Janus N - - 2012
BackgroundOne million people worldwide benefit from chronic dialysis, with an increased rate in Western countries of 5% yearly. Owing to increased incidence of cancer in dialyzed patients, the management of these patients is challenging for oncologists/nephrologists.Patients and methodsThe CANcer and DialYsis (CANDY) retrospective multicenter study included patients under chronic dialysis ...
Partovi Sasan - - 2012
ABSTRACT: INTRODUCTION: Muscle symptoms in systemic sclerosis (SSc) may originate from altered skeletal muscle microcirculation, which can be investigated by means of blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI). METHODS: After ethics committee approval and written consent, 11 consecutive SSc patients (5 men, mean age 52.6 years, mean ...
Michael Amanda - - 2012
Abstract Laparoscopic radical nephrectomy is commonly used to treat renal masses. Given the ubiquitous presence of this technique, rare complications are becoming more commonplace. It is thus essential that practicing urologists be aware of all possible complications as well as the novel management approaches that exist. This report presents a ...
Haranczyk Maciej - - 2012
Congeners are molecules based on the same carbon skeleton but different by the number of substituents and/or a substitution pattern. Examples are 1-chloronaphthalene, 1,4-dichloronaphthalene and 1,3,8-trichloronaphthalene. Various Persistent Organic Pollutants (POPs) exist in the environment as families of congeners. Very large numbers of possible congeners make their experimental characterization and ...
Filippi Andrea Riccardo - - 2012
Abstract Aim of the study was investigating whether iPET is prognostic in a cohort of early stage patients homogeneously treated with 3-4 ABVD cycles followed by 30 Gy Involved Field Radiotherapy. Eighty patients were selected (stage I-IIA HL, availability of iPET, minimum follow-up of 12 months), and after central review, ...
Walsh Alex J - - 2012
BACKGROUND AND OBJECTIVES: With the increasing use of fluorescence in medical applications, a comprehensive understanding of the effect of temperature on tissue autofluorescence is essential. The purpose of this study is to explore the effect of temperature on the fluorescence of porcine cornea and rat skin and determine the relative ...
Stafforst Thorsten - - 2012
Checking for mistakes: By conjugating a catalytic domain with a guide RNA, deamination activity can be harnessed to repair a specific codon on mRNA. This method can be used for the highly selective repair of point mutations in mRNA by site-selective editing.
Kim Dong-Yeon - - 2012
Radiolabeled lipophilic cationic compounds, such as (18)F-labeled phosphonium salt, accumulate in the mitochondria through a negative inner transmembrane potential. The purpose of this study was to develop and evaluate ((18)F-fluoropentyl)triphenylphosphonium salt ((18)F-FPTP) as a myocardial PET agent. METHODS: A reference compound of (18)F-FPTP was synthesized via 3-step nucleophilic substitution reactions ...
Moyano F Revelles - - 2012
Objective:To compare the effectiveness of proprioceptive neuromuscular facilitation combined with exercise, classic stretching physiotherapy intervention, and educational intervention at improving patient function and pain in patients with patellofemoral pain syndrome.Design:Randomized, controlled, blind trial over four months.Setting:Urban population, Spain.Participants:Patients undergoing primary care for retropatellar pain.Intervention:Subjects were allocated on three different treatment ...
Sarker Majher I - - 2012
N-(9-Oxothioxanthenyl)benzothiophene carboxamides bearing leaving groups (LG(-) = Cl(-), PhS(-), HS(-), PhCH(2)S(-)) at the C-3 position of the benzothiophene ring system photochemically cyclize with nearly quantitative release of the leaving group, LG(-). The LG(-) photoexpulsions can be conducted with 390 nm light or with a sunlamp. Solubility in 75% aqueous CH(3)CN ...
Kodoth Vivek N - - 2012
Introduction : Insulation defects with externalized conductors have been reported in the St. Jude Riata(®)  family of defibrillation leads (St. Jude Medical, Sylmar, CA, USA). The objective of the Northern Ireland Riata(®)  lead screening program was to identify insulation defects and externalized conductors by systematic fluoroscopic and electrical assessment in ...
Hwang Doseok - - 2012
Mast cells are primarily responsible for IgE-mediated allergic responses. The activation level of mast cells is reflected in their degree of degranulation. This can in turn be determined by measuring the amount of β-hexosaminidase release, a key parameter in degranulation. In this study, 40 flavone derivatives, including flavone, 14 methoxyflavones, ...
Kumamoto Hiroki - - 2012
4-exo-trig Cyclization reaction of a 4-pentenyl carbon radical containing the gem-difluoromethylene moiety adjacent to a radical accepting α,β-unsaturated ester was found to proceed efficiently to furnish a novel gem-difluorocyclobutane derivative. The cyclized product could be transformed into a gem-difluoromethylene analogue of oxetanocin T.
Kandane-Rathnayake Rangi K - - 2012
INTRODUCTION: The Australian and New Zealand Haemostasis Registry (ANZHR) included patients who received off-licence recombinant activated factor VII (rFVIIa) for critical bleeding from 2000 to 2009. Approximately 1.3% of the ANZHR patients were Jehovah's Witnesses (JWs). We compared them with the non-JW patients in the registry. METHODS: Patient characteristics (e.g. ...
Ruiz José - - 2012
Four new dinuclear complexes [Ni(μ-L)(μ-OAc)Ni(H(2)O)(2)]NO(3) (), Ni(μ-L)(μ-OBz)Ni(H(2)O)(MeOH)]NO(3)·3MeOH (), [Ni(μ-L)(μ-9-An)Ni(H(2)O)(MeOH)]NO(3) () and [Ni(μ-L)(μ-OAc)Ni(H(2)O)(N(3))]·CH(3)OH () have been prepared from the compartmental ligand N,N',N''-trimethyl-N,N''-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine (H(2)L) and different carboxylate ligands (OBz = benzoate and 9-An = 9-anthracenecarboxylate), and then magnetically and structurally characterized. The X-ray structures of these complexes reveal that the Ni(2+) ions ...
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