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Chen Wei - - 2012
In this study, we demonstrate a more sensitive colorimetric assay for the detection of melamine based on the strong attraction between exocyclic amine groups of melamine and surface-bound AuCl(4)(-)/AuCl(2)(-) ions on bare gold nanoparticles prepared by the borohydride reduction method. This method is rather simple without further modification of gold ...
Noda Haruna - - 2012
CRTC1-MAML2 and CRTC3-MAML2 fusions have been associated with favorable clinicopathological features of mucoepidermoid carcinoma. However, significance of MAML2 gene split has not been fully clarified. Ninety-five mucoepidermoid carcinomas (paraffin-embedded materials) were analyzed for CRTC1-MAML2 and CRTC3-MAML2 fusions by the reverse transcription polymerase chain reaction (RT-PCR) and for the MAML2 gene ...
Zhu Ye - - 2012
The large volume of research studying hydrogenation catalysis might suggest that stereoselective hydrogenation of alkenes is a solved problem, but we believe the most important parts of asymmetric hydrogenation methodology remain unmastered. The most popular chiral catalysts, Rh- and Ir-diphosphine complexes, do not hydrogenate the largest categories of prochiral alkenes, ...
Le Berre Maël - - 2012
The quest to understand how the mechanical and geometrical environment of cells impacts their behavior and fate has been a major force driving the recent development of new technologies in cell biology research. Despite rapid advances in this field, many challenges remain in order to bridge the gap between the ...
Botti Gerardo - - 2012
Malignant melanoma is a very representative disease in terms of tumor progression processes. During its evolution, a series of events takes place; among these, the cells' 'out-of-control' growth and loss of homeostasis play crucial roles in the genesis of the tumor itself and its subsequent progression. These events involve several ...
Zhou Yinghong - - 2012
The interaction between host and donor cells is believed to play an important role in osteogenesis. However, it is still unclear how donor osteogenic cells behave and interact with host cells in vivo. The purpose of this study was to track the interactions between transplanted osteogenic cells and host cells ...
Mignemi Nicholas A - - 2012
Despite reports of sex steroid receptor and COX2 expression in desmoid-type fibromatosis, responses to single agent therapy with anti-estrogens and nonsteroidal anti-inflammatory drugs are unpredictable. Perhaps combination pharmacotherapy might be more effective in desmoid tumors that co-express these targets. Clearly, a further understanding of the signaling pathways deregulated in desmoid ...
Sivertsen Tine B - - 2012
AIMS: i) to assess how dental health workers of the Public Dental Service, PDS, carry out endocarditis prophylaxis related to dental treatment of children and adolescents with congenital heart defects (CHD) and to identify factors influencing their appropriate use of guidelines ii) to assess how dental health workers perceive any ...
Singh Raman K - - 2012
The possibility of quantitative reaction analysis on the orbital energies of long-range corrected density functional theory (LC-DFT) is presented. First, we calculated the Diels-Alder reaction enthalpies that have been poorly given by conventional functionals including B3LYP functional. As a result, it is found that the long-range correction drastically improves the ...
Gu Huang - - 2012
Decision making ability has been reported to be impaired in schizophrenia patients, but no research has examined the genetic bases of this impairment. The current study investigated how decision making was affected by the genetic variants in the serotonin transporter gene (triallelic 5-HTTLPR) and serotonin receptor 1A gene (rs6295) and ...
Legrand C - - 2012
The displacement effect of cylindrical ionization chambers is taken into account either by an effective point of measurement (EPOM) or, alternatively, by using a displacement correction factor. The dependence of these effects on water was examined as a function of the cavity radius for (60)Co gamma radiation in a previous ...
Shepherd C - - 2012
PI3 K, mTOR and NOTCH pathways are frequently dysregulated in T-ALL. Blockade of PI3 K and mTOR with the dual inhibitor PI-103 decreased proliferation in 15 T-ALL cell lines tested, inducing cell death in 3. Combined PI3K/mTOR/NOTCH inhibition (with a gamma-secretase inhibitor (GSI)) led to enhanced cell-cycle arrest and to subsequent cell ...
Lalmi B - - 2012
A new table top technique is used to simultaneously analyze the local morphology of crystalline surfaces as well as the misalignment of large scale domains at the topmost surface layer. The approach is based on fast atom diffraction at grazing incidence (GIFAD); the diffraction pattern yields the structural characteristics and ...
Sellu D H - - 2012
BACKGROUND: In order to minimise the risk of blood transfusion errors, all healthcare professionals who participate in the transfusion process are required to be assessed as competent. New and innovative methods of training and competency assessment are required to improve the training process. AIM/OBJECTIVE: The aim of this study was ...
Green Patrick A - - 2012
Within the nasal cavity of mammals is a complex scaffold of paper-thin bones that function in respiration and olfaction. Known as turbinals, the bones greatly enlarge the surface area available for conditioning inspired air, reducing water loss, and improving olfaction. Given their functional significance, the relative development of turbinal bones ...
Drake M - - 2012
Cloacal swabs and caecal contents sampled from 58 cane toads (Bufo marinus) in St George's parish, Grenada, during a 7-month period in 2011 were examined by an enrichment and selective culture method for presence of Salmonella spp. Twenty-four (41%) toads were positive for Salmonella spp. of which eight were Salmonella ...
Fernandes C - - 2012
BACKGROUND: Citrobacter koseri has not been associated to infection caused by blood component transfusions. CASE REPORT: A 46-year-old female patient presented sudden chills, dyspnoea, and tachycardia during a transfusion from a unit of packed red blood cells. Citrobacter koseri was isolated in the two sample collected from the patient and ...
Taylor Stephanie M - - 2012
A combination of complementary cluster ligands results in the formation of a new calixarene-supported ferromagnetic [Mn(5)] cage that displays the characteristic bonding modes of each support.
Rummel Seth - - 2012
The breast tumor microenvironment plays an active role in tumorigenesis. Molecular alterations have been identified in tumor-associated stroma; however, there is considerable debate as to whether the stroma is characterized by genomic instability or whether detection of chromosomal alterations reflects technological artifact rather than the true genomic content of the ...
Mei-Dan Elad - - 2012
Abstract Objective: To examine whether plasma levels of aspartate transaminase (AST) and alanine transaminase (ALT) during the first 20 weeks of pregnancy can predict preeclampsia in the second half of pregnancy. Methods: The study population included 15010 registered births. Receiver operating characteristic (ROC) curve analysis was used to describe the ...
Qi Sara D - - 2012
Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the exogenous expression of defined transcription factors. iPSCs share the defining features of embryonic stem cells (ESCs) in that they are able to self-renew indefinitely and maintain the potential to develop into all cell types of the body. These ...
Wilkens Verena - - 2012
Mitochondria are involved in cellular energy supply, signaling and apoptosis. Their ability to fuse and divide provides functional and morphological flexibility and is a key feature in mitochondrial quality maintenance. To study the impact of mitochondrial fusion/fission on the reorganization of inner membrane proteins, OXPHOS complexes in mitochondria of different ...
Mattoso Crs - - 2012
Plasmatic concentrations of von Willebrand Factor (vWF) increase during pregnancy in humans and dogs; however the mechanism of such increase is still not well defined. The aims of this study were: (i) to evaluate changes in vWF concentration during pregnancy and during the subsequent oestrous cycle in bitches affected and ...
Legood R - - 2012
Previous studies have indicated that human papillomavirus (HPV) testing as a triage for managing equivocal cytology is cost-effective. The aim of this study was to assess the costs of alternative roll-out options. Detailed cost estimates were collected from six laboratories where HPV triage had been implemented. Costs were assessed for ...
Krebbekx Willemijn - - 2012
OBJECTIVES: A gap between health services research and practice has been identified: research findings often do not find their way into practice. Our objective was to explore the potential of collaborative research to bridge this gap in one specific area, health promotion, and to determine factors that influence the development ...
Kimoto Takaya - - 2012
The solution-dispersed-state and polymer-dispersed-state circular dichroism (CD) and circularly polarized luminescence (CPL) properties of chiral binaphthyl fluorophores could be controlled by the choice of open- or closed-type substituents on the binaphthyl units and by the axial chirality of the binaphthyls.
Cheung Jonah - - 2012
Human acetylcholinesterase (AChE) is a significant target for therapeutic drugs. Here we present high resolution crystal structures of human AChE, alone and in complexes with drug ligands; donepezil, an Alzheimer's disease drug, binds differently to human AChE than it does to Torpedo AChE. These crystals of human AChE provide a ...
Swanick Kalen N - - 2012
Improved luminophore: The electrochemiluminescence (ECL) of an iridium complex self-enhanced up to 16 times is reported. Three excited states were observed in the emission spectra. The ECL efficiency of this complex is the highest reported for an iridium complex.
Cheung Yiu-Him - - 2012
Purpose. Lectin from the edible mushroom Agaricus bisporus (ABL) was found to inhibit cell proliferation of some ocular and cancer cell-lines. To elucidate how ABL inhibited retinal pigment epithelial (RPE) cell proliferation, we investigated the changes in cell cycle distribution and cell proliferation-related signalling pathways after ABL treatment. Methods. Primary ...
Moskovic Daniel J - - 2012
Introduction.  Testosterone deficiency (TD) imposes a substantial public health burden in the U.S. We modeled the costs associated with TD-related sequelae including cardiovascular disease (CVD), diabetes mellitus (DM), and osteoporosis-related fractures (ORFs). Aim.  To quantify the incremental cost burden imposed by TD's cardiometabolic sequelae. Method.  Incidence, prevalence, and mortality of ...
Huang Feng - - 2012
In this communication, a thermolysis route is developed to synthesize novel Cu(1.94)S-ZnS-Cu(1.94)S nanoheterostructures with interesting sandwich-like architectures, taking Cu(1.94)S nanoplates as precursors. Evidently, the trimeric nanostructure is formed by a three-stage process, which includes the Zn-oleate induced assembling of Cu(1.94)S nanoplate couples, the heteronucleation and growth of a ZnS layer ...
Cheng Ke - - 2012
Large-scale periodic gold network electrodes were fabricated using the developed and versatile nanosphere lithography technique. The fabrication processes, structural characterizations and network formation mechanism were described in detail. An enhanced optical transmission peak was observed from the transmission spectrum, which could be assigned to the extraordinary transmission mediated commonly by ...
Massier Sébastien - - 2012
AIMS: Pulsed Light (PL) technology is a surface decontamination process that can be used on food, packaging or water. PL efficiency may be limited by its low degree of penetration or because of a shadow effect. In these cases, surviving bacteria will be able to perceive PL as a stress. ...
Heyer Antonia - - 2012
We recently showed that the two-component system (TCS) HrrSA plays a central role in the control of heme homeostasis in the Gram-positive soil bacterium Corynebacterium glutamicum. Here, we characterized the function of another TCS of this organism, ChrSA, which exhibits significant sequence similarity to HrrSA, and provide evidence for cross-regulation ...
Li Yu-Ting - - 2012
Background. The standard practice in the operating room (OR) is having a surgical technician deliver surgical instruments to the surgeon quickly and inexpensively, as required. This human "in the loop" system may result in mistakes (eg, missing information, ambiguity of instructions, and delays). Objective. Errors can be reduced or eliminated ...
Li Lin - - 2012
When I look into your cells: A two-photon dye (Flu7) was developed, which strongly fluoresces only upon selective binding to the plasma membrane of mammalian cells. Upon addition of a UV- and phosphatase-controlled quencher (Q12), the system exhibits ON/OFF/ON fluorescence switching and can be used to image membrane-associated receptor-like protein ...
Driedzic William R - - 2012
The aim of the study was to assess if mechanisms of glucose trafficking by red blood cells (RBCs) relates to species specific extracellular glucose levels. Atlantic cod (Gadus morhua), Atlantic salmon (Salmo salar), cunner (Tautogolabrus adspersus), and short-horned sculpin (Myoxocephalus scorpius) had plasma glucose levels of 4 mmol l(-1), 4.1 ...
Sella Tal - - 2012
Abstract Objective: Studies indicate that gestational diabetes mellitus(GDM) prevalence is increasing worldwide. We aimed to examine secular trends in GDM prevalence and screening practices over the last decade in Israel, and to identify changes in GDM risk factors. Methods: We collected data on all 367,247 pregnant women who were screened for GDM between 2000 and 2010 in Israel's second largest healthcare organization. Multivariable logistic regression ...
Chiang Wen-Hsuan - - 2012
Dual stimuli-responsive hollow nanogel spheres serving as an efficient intracellular drug delivery platform were obtained from the spontaneous co-association of two graft copolymers into the vesicle architecture in aqueous phase. Both copolymers comprise acrylic acid (AAc) and 2-methacryloylethyl acrylate (MEA) units as the backbone and either poly(N-isopropylacrylamide) (PNIPAAm) alone or ...
Sun Jie - - 2012
A series of C(3i) -symmetric bicapped trigonal antiprismatic Cd(8) cages [2X@Cd(8) L(6) (H(2) O)(6) ]⋅n Y⋅solvents (X=Cl(-) , Y=NO(3) (-) , n=2: MOCC-4; X=Br(-) , Y=NO(3) (-) , n=2: MOCC-5; X=NO(3) (-) , Y=NO(3) (-) , n=2: MOCC-6; X=NO(3) (-) , Y=BF(4) (-) , n=2: MOCC-7; X=NO(3) (-) , Y=ClO(4) (-) ...
Silva Aline S - - 2012
The purpose of this study is to characterize native bee plants regarding their capacity to extract and accumulate trace elements from the soil and its consequences to the sanity of the produced pollen. The trace elements Cu, Mn, Pb and Zn were analyzed in soil, plants and bee pollen from ...
Scruggs Philip W - - 2012
BACKGROUND: The validity of common pedometer steps/min guidelines for 1st through 12th grade physical education physical activity (PA) recommendations (i.e., 33% and 50% PA) was investigated. METHODS: Data sets from previous research, where physical education PA was quantified via pedometry, were combined. Participants (1st-12th grade, N=1,152) with concurrent steps/min and ...
Arnold F - - 2012
To mitigate the diesel particle pollution problem, diesel vehicles are fitted with modern exhaust after-treatment systems (ATS), which efficiently remove engine-generated primary particles (soot and ash) and gaseous hydrocarbons. Unfortunately, ATS can promote formation of low-vapor-pressure gases, which may undergo nucleation and condensation leading to formation of nucleation particles (NUP). ...
Zhao Weiyun - - 2012
Carbon monoxide (CO) is a highly toxic gas that can be commonly found in many places. However, it is not easily detected by human olfaction due to its colorless and odorless nature. Therefore, highly sensitive sensors need to be developed for this purpose. Carbon nanotubes (CNTs) have an immense potential ...
Chuykin Ilya - - 2012
During early mammalian development, primitive endoderm (PrE) is specified and segregated away from the pluripotent epiblast. At a later developmental stage, PrE forms motile parietal endoderm (PE) lying proximal to the trophectoderm, and visceral endoderm (VE) that contacts the developing epiblast and extraembryonic ectoderm. Mouse extraembryonic endoderm (XEN) cells were ...
De Smedt Stefan - - 2012
Vernal keratoconjunctivitis (VKC) is a bilateral, usually seasonally recurrent, allergic inflammation of the conjunctiva, characterised by limbal gelatinous hypertrophy and/or upper tarsal giant conjunctival papillae. Although rare in temperate regions, it represents an important cause of hospital referral in many parts of Africa and Asia. Clinical and immunohistochemical studies suggest ...
Thom Simon - - 2012
The use of preventive medications in people at high risk of cardiovascular disease is conceptually straightforward, yet in practice the adoption of such measures is disappointingly low, plus there is wide international variation in preventive therapies.Several barriers might explain this shortfall and variation, but the simplicity and economy of a ...
Dibb M - - 2012
The transcription factor FOXM1 is an important regulator of the cell cycle through controlling periodic gene expression during the G2 and M phases. One key target for FOXM1 is the gene encoding the protein kinase PLK1 and PLK1 itself acts in a positive feedback loop to phosphorylate and activate FOXM1. ...
Chafetz Michael D - - 2012
Justice Scalia warned in his dissent in ATKINS v. VIRGINIA, 536 U.S. 304, 122S.Ct. 2242 (2002) that the problem of feigned mental retardation would complicate the findings in cases involving the death penalty in low IQ individuals. Validity measurement in low IQ individuals has been criticized, largely with questions concerning ...
Crowther Michael J MJ Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester, LE1 7RH, UK. - - 2012
The joint modelling of longitudinal and survival data is a highly active area of biostatistical research. The submodel for the longitudinal biomarker usually takes the form of a linear mixed effects model. We describe a flexible parametric approach for the survival submodel that models the log baseline cumulative hazard using ...
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