Search Results
Results 651 - 700 of 2847
< 9 10 11 12 13 14 15 16 17 18 19 >
Barber Annika F AF Department of Neuroscience, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, - - 2012
Halogenated inhaled anesthetics modulate voltage-gated ion channels by unknown mechanisms. Biophysical analyses revealed novel activation of K(v) channels by the inhaled anesthetic sevoflurane. K(v) channel activation by sevoflurane results from the positive allosteric modulation of activation gating. The unique activation of K(v) channels by sevoflurane demonstrates novel anesthetic specificity and ...
Hopfer Helene - - 2012
Californian Chardonnay was stored in five different wine packaging configurations at three different temperatures for a period of three months to study the combined packaging temperature effects on the sensory and chemical properties of the wines. A trained descriptive panel evaluated aroma, taste, mouthfeel and color, and the results were ...
Kim Tae-Won - - 2012
Context: The root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae) has been widely studied for its hepatoprotective effects against various hepatotoxicants. Objective: The present study evaluated the protective effect of the standardized aqueous extract of P. grandiflorum (BC703) on cholestasis-induced hepatic injury in mice. Materials and methods: BC703 is a ...
Hirakawa Yoshihisa - - 2012
In plants, many nucleus-encoded proteins are targeted to both mitochondria and plastids, and this process is generally mediated by ambiguous N-terminal targeting sequences that are recognized by receptors on both organelles. In many algae, however, plastids were acquired by secondarily engulfing green or red algae, which were retained within the ...
Ansari Daniel - - 2012
Abstract Management of colorectal liver metastases (CRLM) has dramatically changed during the last decade and has now become more multimodal and aggressive, including the use of downstaging chemotherapy, portal vein embolization to increase the function of the liver remnant or both in combination. Radiofrequency ablation is also an option in ...
Wang Yen-Feng - - 2012
Background:Osmophobia is an under-investigated associated symptom in migraine.Objective:To evaluate the clinical correlates and diagnostic utility of osmophobia.Methods:Adult patients with migraine (with or without aura), probable migraine (PM), tension-type headache (TTH), and cluster headache (CH) were recruited retrospectively from our headache registration system. Migraine patients with and without osmophobia were compared. ...
Nygård Yngve - - 2012
Abstract Objective. The prostate cancer gene 3 (PCA3) score in urine is a promising biomarker for prostate cancer. Real-time elastography (RTE) is a well-documented ultrasound modality. The objective of this study was to evaluate the ability to detect significant cancer foci in the prostate with these methods alone and in ...
Zheng Haimei - - 2012
We report on electron beam manipulation and simultaneous transmission electron microscopy imaging of gold nanoparticle movements in an environmental cell. Nanoparticles are trapped with the beam and move dynamically towards the location with higher electron density. Their global movements follow the beam positions. Analysis on the trajectories of nanoparticle movements ...
Maksymowych Walter P - - 2012
ABSTRACT: INTRODUCTION: Inflammation associated with synovial expression of tumour necrosis factor alpha (TNFalpha) is a recognised feature of osteoarthritis (OA), though no studies have yet reported beneficial effects of anti-TNFalpha therapy on clinical manifestations of inflammation in OA. METHODS: We conducted an open label evaluation of adalimumab over 12 weeks ...
Wanniarachchi Sarath - - 2012
A series of rhodium(III) complexes of the redox-active ligand, H(L = bis(4-methyl-2-(1H-pyrazol-1-yl)phenyl)amido), was prepared, and the electronic properties were studied. Thus, heating an ethanol solution of commercial RhCl(3)·3H(2)O with H(L) results in the precipitation of insoluble [H(L)]RhCl(3), 1. The reaction of a methanol suspension of [H(L)]RhCl(3) with NEt(4)OH causes ligand ...
Rezanejad Habib - - 2012
Abstract Pluripotent stem cells (PSCs) have the potential to differentiate into many cell types and therefore can be a valuable source for cell therapy. Embryonic stem cells (ESCs), which are derived from the inner cell mass (ICM) of the blastocyst, are representative of PSCs. However, use of these cells has ...
Park Man Jae - - 2012
Excess electron transfer dynamics in DNA hairpins was investigated by femtosecond laser flash photolysis of a donor-DNA-acceptor system using N,N-dimethylaminopyrene and diphenylacetylene as an electron donor and acceptor, respectively. It was revealed that the excess electron hopping rate between T's is faster than that of the hole.
Xiao Haibo - - 2012
A series of novel 9,9'-spirobifluorene-bridged donor-π-acceptor chromophores containing triarylamine moieties were easily synthesized starting from the readily available reagent 4,4'-dimethylbiphenyl. These chromophores were found to combine excellent transparency in the visible region, high thermal stabilities, and large optical nonlinearity.
Dutertre Sébastien S Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, - - 2012
Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors and discuss recently emerging functions of distinct GlyR isoforms. GlyRs ...
Ertaş Gökhan - - 2012
Abstract Introduction: Red cell distribution width (RDW) has been associated with poor outcomes in patients with cardiovascular diseases. However, little is known about the role of RDW in prediction of new-onset atrial fibrillation (AF) after coronary artery bypass grafting (CABG). We aimed to investigate the relation between the RDW and ...
Chen Songbiao - - 2012
Interactions between rice and Magnaporthe oryzae involve the recognition of cellular components and the exchange of complex molecular signals from both partners. How these interactions occur in rice cells is still elusive. We employed robust-long serial analysis of gene expression (RL-SAGE), massively parallel signature sequencing (MPSS), and sequencing by synthesis ...
van der Pas R R Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands. - - 2012
The antifungal agent ketoconazole is often used to suppress cortisol production in patients with Cushing's syndrome (CS). However, ketoconazole has serious side effects and is hepatotoxic. Here, the in vitro effects of ketoconazole and fluconazole, which might be less toxic, on human adrenocortical steroidogenesis were compared. The effects on steroidogenesis ...
Horemans Benjamin - - 2012
Urban atmospheres in modern cities carry characteristic mixtures of particulate pollution which are potentially aggravating for chronic respiratory patients (CRP). Although air quality surveys can be detailed, the obtained information is not always useful to evaluate human health effects. This paper presents a novel approach to estimate particle deposition rates ...
Kohda Naohisa - - 2012
Abstract Objective: To measure the forces delivered by thermoplastic appliances made from three materials and investigate effects of mechanical properties, material thickness, and amount of activation on orthodontic forces. Materials and Methods: Three thermoplastic materials, Duran (Scheu Dental), Erkodur (Erkodent Erich Kopp GmbH), and Hardcast (Scheu Dental), with two different ...
Wang Ziwen - - 2012
On the basis of our previous structure-activity relationship (SAR) and antiviral mechanism studies, a series of phenanthroindolizidines and their analogues 3-20 were designed, targeting tobacco mosaic virus (TMV) RNA, synthesized, and systematically evaluated for their antiviral activity against TMV. The bioassay results showed that most of these compounds displayed good ...
Furuyama Taniyuki - - 2012
Supersized: Three pentaazapentaphyrin derivatives, that is, the superazaporphyrins (SAzPs), as well as a superphthalocyanine (SPc) and a mixed low-symmetry derivative have been prepared and characterized. Decaaryl SAzPs have a distorted (4n+2) π structure and show the Q bands at about λ=840-880 nm. These compounds are relatively air stable.
Gyllenhammer Lauren Elizabeth - - 2012
BACKGROUND: Lifetime physical activity (PA) is associated with decreased breast cancer (BC) risk; reports suggest that PA during adolescence contributes strongly to this relationship. PA lowers production of sex hormones, specifically estradiol, or decreases insulin resistance (IR), thereby lowering risk. Overweight Latina adolescents are insulin resistant and exhibit low levels ...
Vicente Js - - 2012
The aim of this work was to study the influence of embryonic and maternal genotype of two lines of rabbits selected by growth rate (line R) and litter size at weaning (line A) on prenatal survival. Embryos were recovered at 48 h of gestation from R and A donors (39 and ...
Chu Fu-Lu - - 2012
Objectives: To determine the effects of heptad repeat regions (HRs) and N-linked carbohydrate sites of the Newcastle disease virus hemagglutinin-neuraminidase (HN) protein on fusion of HN and fusion (F) proteins and HN-F interaction. Methods: We mutated six 'a' residues in the HRs and four asparagines in N-linked carbohydrate sites to ...
Samuel Prinson P - - 2012
The reactions of silylenes with organic azides are quite diverse, depending on the substituents of the silylene center and on the nature of the azide employed. Elusive silaimine with three-coordinate silicon atom L(1)SiN(2,6-Triip(2)-C(6)H(3)) (5) {L(1) = CH[(C═CH(2))(CMe)(2,6-iPr(2)C(6)H(3)N)(2)] and Triip = 2,4,6-triisopropylphenyl} was synthesized by treatment of the silylene L(1)Si (1) ...
Komatsu Yuki - - 2012
Background: Whether procedural termination of persistent atrial fibrillation (AF) is necessary for optimal clinical efficacy still remains controversial. We sought to characterize the patients with persistent AF in whom procedural AF termination impacted an improved clinical outcome after ablation. Methods: We retrospectively assessed 132 patients (61.0 ± 9.3 years, 114 ...
Jeong Seung Hee - - 2012
Recently, microfluidic stretchable electronics has attracted great interest from academia since conductive liquids allow for larger cross-sections when stretched and hence low resistance at longer lengths. However, as a serial process it has suffered from low throughput, and a parallel processing technology is needed for more complex systems and production ...
Gebala Magdalena - - 2012
Label-free electrochemical detection of DNA hybridization with high selectivity and sensitivity is only achievable if the properties of DNA at an electrified interface are understood in depth. After a short summary of concepts of electrochemical DNA detection as well as initial attempts towards label-free DNA assays the review discusses the ...
Zhou Jun - - 2012
In my (DNA) dreams: A tri-G-quadruplex was constructed from three strands (T1-T3) of DNA using duplex formation to guide the G-rich tracts into close proximity with the addition of Li(+) ions. The defined G-quadruplex structure was formed upon addition of Na(+) ions and characterized by gel electrophoresis and spectroscopy.
Hong Bor-Cherng - - 2012
A new method has been developed for the enantioselective synthesis of highly functionalized hydropentalenes bearing up to four stereogenic centers with high stereoselectivity (up to 99% ee). This process combines an enantioselective organocatalytic anti-selective Michael addition with a highly efficient one-pot reduction/lactonization/Pauson-Khand reaction sequence. The structures and absolute configurations of ...
Tan Min - - 2012
Leucyl-tRNA synthetase from Escherichia coli (EcLeuRS) has evolved both tRNA-dependent pre- and post-transfer editing capabilities to ensure catalytic specificity. Both editing functions rely on entry of the tRNA CCA tail into the editing domain of the LeuRS enzyme, which, according to X-ray crystal structural studies, leads to a dynamic, disordered ...
Demergis Vassili - - 2012
We demonstrate nanometer precision manipulation of multiple nanoparticles at room temperature. This is achieved using the optical binding force, which has been assumed to be weak compared to the optical gradient and scattering forces. We show that trapping by the optical binding force can be over 20 times stronger than ...
Catalano Jeffrey G - - 2012
Introduction of coal fly ash into aquatic systems poses a potential environmental hazard because of its heavy metal content. Here we investigate the relationship between solid phase transformations, fluid composition, and metal release and speciation during prolonged wet aging of a class C and class F coal fly ash. The ...
Baligand Celine - - 2012
BACKGROUND: In vivo gene electrotransfer is frequently used in preclinical gene therapy. Many studies have attempted to optimize protocols efficiency while reducing muscle damage. Most of them reported histological evidence of muscle degeneration and completion of regeneration within 15 days. The functional consequences have rarely been addressed, which may reflect the ...
Fagerland Morten W - - 2012
We examine goodness-of-fit tests for the proportional odds logistic regression model-the most commonly used regression model for an ordinal response variable. We derive a test statistic based on the Hosmer-Lemeshow test for binary logistic regression. Using a simulation study, we investigate the distribution and power properties of this test and ...
Saleh Amr A E - - 2012
Optical trapping using focused laser beams has emerged as a powerful tool in the biological and physical sciences. However, scaling this technique to nano-sized objects remains challenging due to the diffraction limit of light and the high power levels required for nanoscale trapping. In this paper, we propose plasmonic coaxial ...
Bhattacharyya Koyel X - - 2012
This paper describes a new series of organometallic water-soluble chelators combining a redox moiety (ferrocene) and a selective Ca(2+) chelator (BAPTA) separated by an ethynyl bridge. We report the synthesis and characterization of organometallic derivatives of the BAPTA chelator featuring one () and two ferrocenyl () moieties. Single crystal X-ray ...
Nissen Stephanie S Department of Psychiatry, University of California San Diego, La Jolla 92093, - - 2012
We have previously reported genome-wide significant linkage of bipolar disorder to a region on 22q12.3 near the marker D22S278. Towards identifying the susceptibility gene, we have conducted a fine-mapping association study of the region in two independent family samples, an independent case-control sample and a genome-wide association dataset. Two hundred ...
Mukaeda Yuki - - 2012
The Kobayashi aldol reaction is one of the most powerful methods to synthesize the polyketide skeleton and has been applied to the total synthesis of natural products. This methodology has been used to construct anti-aldol products, and only a few precedents on the syn-selective Kobayashi aldol reaction are known. A ...
Park Seong Bin - - 2012
ABSTRACT: Edwardsiella tarda is one of the serious fish pathogens, infecting both cultured and wild fish species. Research on edwardsiellosis has revealed that E. tarda has a broad host range and geographic distribution, and contains important virulence factors that enhance bacterial survival and pathogenesis in hosts. Although recent progress in ...
Hayashi Yugo - - 2012
Oxidized horse cytochorme c (cyt c) has been shown to oligmerize by domain swapping its C-terminal helix successively. We show that the structural and thermodynamic properties of dimeric Hydrogenobacter thermophilus (HT) cytochrome c(552) (cyt c(552)) and dimeric horse cyt c are different, although both proteins belong to the cyt c ...
Huang Shaobai - - 2012
Mitochondria complex II (succinate dehydrogenase, SDH) plays a central role in respiratory metabolism as a component of both the electron transport chain and the tricarboxylic acid cycle. We report the identification of an SDH assembly factor by analysis of T-DNA insertions in At5g51040, a protein with unknown function that was ...
Hoffman Martin D - - 2012
Abstract This study examined whether urine dipstick testing might be useful to predict the development of acute kidney injury after an ultramarathon. Participants in the 2011 161-km Western States Endurance Run underwent post-race blood and urine dipstick analyses. Of the 310 race finishers, post-race urine dipstick testing was completed on ...
Skrøvseth Stein Olav SO Norwegian Centre for Integrated Care and Telemedicine, University Hospital of North Norway, Tromsø, - - 2012
Persons with type 1 diabetes who use electronic self-help tools, most commonly blood glucose meters, record a large amount of data about their personal condition. Mobile phones are powerful and ubiquitous computers that have a potential for data analysis, and the purpose of this study is to explore how self-gathered ...
Bartalena L L Department of Clinical and Experimental Medicine, University of Insubria, Endocrine Unit, Ospedale di Circolo, 21100 Varese, Italy. - - 2012
Optimal doses of i.v. glucocorticoids for Graves' orbitopathy (GO) are undefined. We carried out a multicenter, randomized, double-blind trial to determine efficacy and safety of three doses of i.v. methylprednisolone in 159 patients with moderate to severe and active GO. Patients were randomized to receive a cumulative dose of 2.25, ...
Sepúlveda María - - 2012
OBJECTIVE: The aim of this study is to report the clinical profile and outcome of longitudinally extensive transverse myelitis (LETM). METHODS: We prospectively studied adult patients who presented with LETM from January 2008 to December 2011. Information on demographic, clinical course, magnetic resonance imaging (MRI) and outcome was collected. HLA-DRB1 ...
Lin Xiao-Ming - - 2012
Assembly of Zn(NO(3) )(2) with the tripodal ligand H(3) TCPB (1,3,5-tri(4-carboxyphenoxy)benzene) affords two porous isoreticular metal-organic frameworks, [Zn(3) (TCPB)(2) ⋅2DEF]⋅ 3DEF (1) and [Zn(3) (TCPB)(2) ⋅2H(2) O]⋅ 2H(2) O⋅4DMF (2). Single-crystal X-ray diffraction analyses reveal that 1 crystallizes in the monoclinic space group P2(1) /c and possesses a 2D network ...
Nix Jeffrey W - - 2012
What's known on the subject? and What does the study add? MRI has been shown to improve prostate cancer detection rates. Pinto et al. (J Urol 2011; 86: 1281-5) reported their outcomes on 101 patients with low, moderate or high suspicion lesions on multiparametric MRI that were subsequently targeted via ...
Ahmadi Hamed - - 2012
What's known on the subject? and What does the study add? Clinical stage is an integral part of outlining treatment strategy and counselling patients with bladder cancer. The discordance rate between clinical stage and pathological stage, however, is currently high with more than 40% of patients with presumed organ-confined disease ...
Hu Xiao-Bo - - 2012
Three pillar[n]arenes (n = 8-10) were synthesized. X-ray analysis demonstrated that, different from early reported small pillar[n]arenes (n = 5, 6), these larger macrocycles gave rise to two cavities. (1)H NMR and MS experiments revealed that pillar[9]arene complexed one n-octyltrimethyl ammonium in chloroform, while pillar[10]arene could complex two.
< 9 10 11 12 13 14 15 16 17 18 19 >