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Results 601 - 650 of 2847
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Farsi Zohreh - - 2012
There is huge number of oligomeric proteins which show allosteric behavior as soon as their allosteric effector is provided. Thermus sp. GH5 methylglyoxal synthase (TMGS) is also a homohexameric protein which displays cooperative behavior when phosphate concentration increases. Previous studies on this enzyme have indicated that binding of phosphate leads ...
Kreuter Justin - - 2012
Thrombotic microangiopathy is a pathological process that results in thrombocytopenia, schistocytes, and organ ischemia. A wide variety of causes of thrombotic microangiopathy have been described, each associated with a different pathological stimulus and predisposition toward certain vascular territories. This review will summarize our understanding of key drugs that have been ...
Kahouadji Y - - 2012
OBJECTIVES: Previous studies in HIV-infected populations have yielded conflicting results on the effect of antiretroviral therapy (ART) on cognition. Our objective was to investigate the effect of several years of ART with stable central nervous system penetration effectiveness (CPE) score on neuropsychological performance in HIV-infected individuals. METHODS: We analysed a ...
Slany Michal - - 2012
The isolation of nontuberculous mycobacteria (NTM) from clinical specimens has become very common in recent years. Such organisms are typically environmental and occasionally pathogenic for humans and animals. Standard diagnosis of mycobacterial infections relies on direct examination and culture. However, molecular tools are now available which allow quicker and more ...
Yeh Li-Hsien - - 2012
A novel polyelectrolyte (PE)-modified nanopore, comprising a solid-state nanopore functionalized by a non-regulated PE brush layer connecting two large reservoirs, is proposed to regulate the electrokinetic translocation of a soft nanoparticle (NP), comprising a rigid core covered by a pH-regulated, zwitterionic, soft layer, through it. The type of NP considered ...
Wang Xiao-Ming - - 2012
ABSTRACT: INTRODUCTION: X-linked adrenoleukodystrophy (X-ALD) is a complex disorder with variable expressivity that affects the nervous, adrenocortical, and male reproductive systems. Although ABCD1 mutations are known to provide the genetic basis for X-ALD, its pathogenesis is not fully elucidated. While elevated very long chain fatty acid (VLCFA) levels in blood ...
Becker Dominic - - 2012
The Ireland-Claisen rearrangement is the central step in the synthesis of tubuphenylalanine, a key building block of the highly antitumor-active tubulysins. The rearrangement of substituted β-amino acid allyl esters, in combination with subsequent decarboxylation and oxidative cleavage of the double bond, allows the highly stereoselective introduction of substituents into the ...
Schramm Patrick - - 2012
ABSTRACT: INTRODUCTION: Sepsis-associated delirium (SAD) increases morbidity in septic patients and, therefore, factors contributing to SAD should be further characterized. One possible mechanism might be the impairment of cerebrovascular autoregulation (AR) by sepsis, leading to cerebral hypo- or hyperperfusion in these haemodynamically unstable patients. Therefore, the present study investigates the ...
Wu Gang - - 2012
In this work, we present a synthesis approach for nitrogen-doped graphene-sheet-like nanostructures via the graphitization of a heteroatom polymer, in particular polyaniline, under the catalysis of a cobalt species using multi-walled carbon nanotubes (MWNTs) as a supporting template. The graphene-rich composite catalysts (Co-N-MWNTs) exhibit substantially improved activity for oxygen reduction ...
Malmeström Clas - - 2012
BACKGROUND: Recently, a polymorphism in the LIGHT gene was shown to increase the risk of multiple sclerosis (MS) in a genome-wide association study (GWAS). OBJECTIVE: Our aim was to investigate if serum levels of LIGHT were affected by this polymorphism and by the disease itself. METHODS: Serum levels of LIGHT ...
Kopecná Jana J Institute of Microbiology, Department of Phototrophic Microorganisms, Academy of Sciences, 37981 Trebon, Czech - - 2012
Cyanobacteria acclimate to high-light conditions by adjusting photosystem stoichiometry through a decrease of photosystem I (PSI) abundance in thylakoid membranes. As PSI complexes bind the majority of chlorophyll (Chl) in cyanobacterial cells, it is accepted that the mechanism controlling PSI level/synthesis is tightly associated with the Chl biosynthetic pathway. However, ...
Yoh Kousei - - 2012
Abstract Objective: To assess changes in quality of life (QOL) and pain in raloxifene-treated Japanese women with postmenopausal osteoporosis. Research Design and Methods: This prospective, postmarketing observational study was conducted at 60 Japanese hospitals from September 2007 to February 2009 and included Japanese women with postmenopausal osteoporosis who were new ...
Fabri Rodrigo L - - 2012
The bioactivity guided fractionation of the dichloromethane extract of Mitracarpus frigidus afforded the pyranonaphthoquinone psychorubrin. This compound, hitherto unknown in the genus Mitracarpus, had its biological activity evaluated against one panel of bacteria and two fungi, three tumor cell lines (HL60, Jurkat and MCF-7) and four Leishmania species. Its identity ...
Kumar Vinod - - 2012
Rock-salt-based honeycomb structures containing Te(VI) and Sb(V) with innumerable prospects of properties and applications were realized in the two new series of mixed-metal oxides of lithium, Li(8)M(2)Te(2)O(12) (M(II) = Co, Ni, Cu, Zn) and Li(8)M(2)Sb(2)O(12) (M(III) = Cr, Fe, Al, Ga). The structures of Li(8)Co(2)Te(2)O(12) and Li(8)Cu(2)Te(2)O(12) were determined by ...
Helal Imed - - 2012
Background: This study evaluates the prevalence of cardiovascular events in autosomal dominant polycystic kidney disease (ADPKD) patients. Methods: We distributed surveys to 1,439 subjects from our ADPKD research database. In total, 426 subjects completed and returned surveys; 7 of these were from children and were excluded from the study. Results: ...
Taylor Michael W MW Centre for Microbial Innovation, School of Biological Sciences, University of Auckland, Auckland, New Zealand. - - 2013
Numerous studies have reported the existence of sponge-specific 16S ribosomal RNA (rRNA) gene sequence clusters, representing bacteria found in sponges but not detected in other environments, such as seawater. The advent of deep-sequencing technologies allows us to examine the rare microbial biosphere in order to establish whether these bacteria are ...
Kim Dong-Yeon - - 2012
Radiolabeled lipophilic cationic compounds, such as (18)F-labeled phosphonium salt, accumulate in the mitochondria through a negative inner transmembrane potential. The purpose of this study was to develop and evaluate ((18)F-fluoropentyl)triphenylphosphonium salt ((18)F-FPTP) as a myocardial PET agent. METHODS: A reference compound of (18)F-FPTP was synthesized via 3-step nucleophilic substitution reactions ...
Wong L-M - - 2012
The controversies concerning possible overtreatment of prostate cancer, highlighted by debate over PSA screening, have highlighted active surveillance (AS) as an alternative management option for appropriate men. Regional differences in the underlying prevalence of PSA testing may alter the pre-test probability for high-risk disease, which can potentially interfere with the ...
Moyano F Revelles - - 2012
Objective:To compare the effectiveness of proprioceptive neuromuscular facilitation combined with exercise, classic stretching physiotherapy intervention, and educational intervention at improving patient function and pain in patients with patellofemoral pain syndrome.Design:Randomized, controlled, blind trial over four months.Setting:Urban population, Spain.Participants:Patients undergoing primary care for retropatellar pain.Intervention:Subjects were allocated on three different treatment ...
Sarker Majher I - - 2012
N-(9-Oxothioxanthenyl)benzothiophene carboxamides bearing leaving groups (LG(-) = Cl(-), PhS(-), HS(-), PhCH(2)S(-)) at the C-3 position of the benzothiophene ring system photochemically cyclize with nearly quantitative release of the leaving group, LG(-). The LG(-) photoexpulsions can be conducted with 390 nm light or with a sunlamp. Solubility in 75% aqueous CH(3)CN ...
Kodoth Vivek N - - 2012
Introduction : Insulation defects with externalized conductors have been reported in the St. Jude Riata(®)  family of defibrillation leads (St. Jude Medical, Sylmar, CA, USA). The objective of the Northern Ireland Riata(®)  lead screening program was to identify insulation defects and externalized conductors by systematic fluoroscopic and electrical assessment in ...
Rastrelli Giulia - - 2012
The classification of subjects as low or high cardiovascular (CV) risk is usually performed by risk engines, based upon multivariate prediction algorithms. However, their accuracy in predicting major adverse CV events (MACEs) is lower in high-risk populations as they take into account only conventional risk factors. To evaluate the accuracy ...
Lummis Sarah C R - - 2012
5-Hydroxytryptamine type 3 (5-HT(3)) receptors are cation-selective Cys loop receptors found in both the central and peripheral nervous systems. There are five 5-HT(3) receptor subunits (A-E), and all functional receptors require at least one A subunit. Regions from noncontiguous parts of the subunit sequence contribute to the agonist-binding site, and ...
Hwang Doseok - - 2012
Mast cells are primarily responsible for IgE-mediated allergic responses. The activation level of mast cells is reflected in their degree of degranulation. This can in turn be determined by measuring the amount of β-hexosaminidase release, a key parameter in degranulation. In this study, 40 flavone derivatives, including flavone, 14 methoxyflavones, ...
Catarino Tatiana - - 2012
Protein acetylation affects synaptic plasticity and memory, but its effects on synapse composition have not been addressed. We found that protein acetylation promotes the dendritic clustering of the excitatory postsynaptic scaffold protein PSD95 in hippocampal neurons, without affecting the total levels of this protein. Cortactin, an F-actin-binding protein enriched in ...
Mulcahy Ben - - 2012
Frailty is a feature of neuromuscular ageing. Here we provide insight into the relative contribution of pre and postsynaptic dysfunction to neuromuscular ageing using the nematode Caenorhabditis elegans. Assays of C. elegans motility highlight a precipitous decline during ageing. We describe a novel deployment of pharmacological assays of C. elegans ...
Piovezan Ronaldo D - - 2012
A challenging aspect of geriatric practice is that it often requires decision-making under conditions of uncertainty. The Script Concordance Test (SCT) is an assessment tool designed to measure clinical data interpretation, an important element of clinical reasoning under uncertainty. The purpose of this study was to develop and analyze the ...
Kitchen Dianne Patricia - - 2012
BACKGROUND: Vitamin K antagonists have been used for many decades and have been traditionally monitored by the measurement of the International Normalised Ratio (INR) in the laboratory. Introduction of Point of Care (POC) testing devices to measure INR has resulted in many tests being undertaken in primary care. External Quality ...
Singhal Dhruv - - 2012
Background Perforator flap breast reconstruction requires increased time for safe perforator dissection, especially the intramuscular course. We describe an adjunctive technique using hydrodissection to assist with the intramuscular perforator dissection.Methods Hydrodissection techniques were used for perforator dissection in 45 consecutive patients (64 flaps) undergoing deep inferior epigastric perforator (DIEP) flap breast reconstruction. ...
Liu Yan-Lin - - 2012
Magnetic-fluorescent particles with targeting functionalities were fabricated by a modified Stöber method and two shapes (spherical and beanpod-like) were obtained by simply tuning the reaction temperature. The two multifunctional probes combined the useful functions of magnetism, fluorescence and FA (folic acid)-targeting recognition into one entity. The products were characterized by ...
Liu Po-Yen - - 2012
BACKGROUND: The androgen receptor (AR) is a main therapeutic target for treatment of prostate cancer (PCa). The natural compound isochaihulactone (K8), which has a chiral center ring and two racemic forms (E-K8 and Z-K8), has anti-tumor effects on multiple cancer types both in vitro and in vivo. Here, we determined ...
Sultan Babar - - 2012
BACKGROUND: Vitamin D, long recognized for its role in bone metabolism and calcium homeostasis, has been increasingly shown to augment innate immunity. 1-α-Hydroxylase, the enzyme responsible for the synthesis of active vitamin D, has been shown to have extrarenal expression in multiple cell types, including airway epithelial cells. The purpose ...
Moghaddam Minoo J - - 2012
A facile, two-step method for chemically attaching single-stranded DNA to graphitic surfaces, represented here by carbon nanotubes, is reported. In the first step, an azide-containing compound, N-5-azido-nitrobenzoyloxy succinimide (ANB-NOS), is used to form photo-adducts on the graphitic surfaces in a solid-state photochemical reaction, resulting in active ester groups being oriented ...
Kurra Narendra - - 2012
We describe a transfer-free method for the fabrication of nanocrystalline graphene (nc-graphene) on SiO(2) substrates directly from patterned carbonaceous deposits. The deposits were produced from the residual hydrocarbons present in the vacuum chamber without any external source by using an electron beam induced carbonaceous deposition (EBICD) process. Thermal treatment under ...
Mendiratta P P Donald W Reynolds Institute on Aging and Department of Geriatrics, College of Medicine, University of Arkansas for Medical Sciences, and Geriatric Research Education and Clinical Center (GRECC), Central Arkansas Veterans Healthcare System (CAVHS), Little Rock, AR, - - 2012
To investigate national trends in percutaneous endoscopic gastrostomy (PEG) tube placement for hospitalized elderly patients from 1993 to 2003. Retrospective analysis of patients ≥ 65 years of age with PEG tube placement from 1993 to 2003 from the Nationwide Inpatient Sample (NIS) database was utilized to calculate PEG placement rates ...
Capra Louise - - 2012
OBJECTIVES: To determine and identify the characteristics and circumstances of femur fractures in ambulatory young children. DESIGN AND SETTING: Retrospective review of 203 ambulatory children, between 1 and 5 years old, presenting with femur fractures to an urban paediatric hospital over a 10-year period. χ(2) And Student's t test were ...
Hawley Karen A - - 2012
BACKGROUND: Sinonasal respiratory epithelial adenomatoid hamartoma (REAH) is a benign glandular proliferation with ciliated epithelium. Little is known about REAH, with only a few published case reports appearing since its original description in 1995. Classically described as an isolated polypoid lesion arising from the nasal septum, more recent descriptions also ...
Pawlicki MiƂosz - - 2012
Behind the wheel: A 10 nm diameter nanoring, containing 24 porphyrin units, has been created by a Vernier-templating self-organization of hexa- or octadente templating units and linear covalently linked porphyrin oligomers. Coordination of a bidentate ligand triggers a conversion of the molecular nanocylinder into a molecular nanoannulus to afford the ...
Chen H-I - - 2012
Smoking is a leading global cause of avoidable mortality. It has been reported that the nicotinic acetylcholine receptor (CHRNA4 and CHRNB2) genes might be associated with smoking behavior in several ethnic populations. However, no study between the 2 genes and nicotine dependence (ND) using a Japanese population has been reported.We ...
Ren Q J - - 2012
We show that coating ZnO nanowires (NWs) with a transition metal, such as Ni, can increase the efficiency of light emission at room temperature. Based on detailed structural and optical studies, this enhancement is attributed to energy transfer between near-band-edge emission in ZnO and surface plasmons in the Ni film ...
Imai Ayano - - 2012
Purpose. To determine whether supernatants of human retinal pigment epithelium (RPE) cells can convert CD4+ T cells into regulatory T cells (Tregs) under Treg induction conditions in vitro and in vivo. Methods. Peripheral blood mononuclear cells were co-cultured with supernatants from TGFβ2-pretreated human RPE lines on anti-CD3-coated plates. Cells were ...
Groll Klaus - - 2012
A handsome couple: Through the use of the simple Pd catalyst [Pd(tmpp)(2) Cl(2) ] (tmpp=tris(2,4,6-trimethoxyphenyl)phosphine) and THF/DMF as solvent, various aryl-, heteroaryl-, benzyl- and alkylaluminum reagents can be readily cross-coupled with aryl or heteroaryl iodides, bromides, and nonaflates, and in special cases even with chlorides and triflates. This cross-coupling tolerates ...
Maitra Radhashree R Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. - - 2012
Medical therapy of patients with malignancy requires a paradigm shift through development of new drugs with a good safety record and novel mechanisms of activity. While there is no dearth of such molecules, one particular agent, "reovirus" is promising by its ability to target cancer cells with aberrant signaling pathways. ...
Urrets-Zavalia Julio A - - 2012
AIMS: To assess the impact of different oxygenation policies on the rate and severity of retinopathy of prematurity (ROP). METHODS: Between January 2003 and December 2006, infants of 1500 g birthweight (BW) or less and/or 32 weeks gestational age (GA) or less, and larger, more mature infants with risk factors ...
Wan Jun - - 2012
Water scarcity has become a constraint for regional economic development in many cities and regions. Water rationing serves as one instrument to constrain water consumption to persuade users to save water and to moderate their consumption. When the supply of water is unable to satisfy demand, a loss of welfare ...
Lopci Egesta - - 2012
Abstract Aim: To verify the potential role and feasibility of carbidopa premedication in pediatric patients undergoing (18)F-DOPA (Fluorine-18 fluorodihydroxyphenylalanine) PET scanning. Materials and Methods: For this limited study, 5 patients (M:F=3:2; mean age 4.8 years) with a positive history for neuroblastoma who had been referred to our institution for instrumental ...
Bourcet Emmanuel - - 2012
The total synthesis of plakotenin, a cytotoxic marine natural product, using a biomimetic Diels-Alder reaction is described in detail. Two approaches were used, whereby the Diels-Alder reaction occurs at different stages of the synthesis. Homo- and nor-plakotenin, related natural products, were also prepared, as well as iso-plakotenin, a diastereoisomer of ...
Boddi Valentina - - 2012
Introduction.  The relational domain of erectile dysfunction (ED) is difficult to investigate in a clinical setting. We developed and validated SIEDY, a 13-item structured interview, that evaluates, besides the organic (Scale 1) and intra-psychic (Scale 3) domains, also the relational one (Scale 2). We previously established a pathological threshold for ...
van der Werf Christine S - - 2012
Purpose:Autosomal recessive congenital short bowel syndrome is caused by mutations in CLMP. No mutations were found in the affected males of a family with presumed X-linked congenital short bowel syndrome or in an isolated male patient. Our aim was to identify the disease-causing mutation in these patients.Methods:We performed mutation analysis ...
Nomoto Yuji - - 2012
In Arabidopsis thaliana, the circadian clock regulates diurnal and photoperiodic plant growth including the elongation of hypocotyls in a time-of-day-specific and short-day (SD)-specific manner. The clock-controlled PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) encoding a basic helix-loop-helix (bHLH) transcription factor plays crucial roles in this regulation. PIF4 is transcribed precociously at the end ...
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