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Yiannakas Marios C - - 2012
BACKGROUND: There are modest correlations between multiple sclerosis (MS) disability and white matter lesion (WML) volumes, as measured by T2-weighted (T2w) magnetic resonance imaging (MRI) scans (T2-WML). This may partly reflect pathological heterogeneity in WMLs, which is not apparent on T2w scans. OBJECTIVE: To determine if ADvanced IMage Algebra (ADIMA), ...
Brito Renan G - - 2012
Citronellol (CT) is a monoterpenoid alcohol present in the essential oil of many medicinal plants, such as Cymbopogom citratus. We evaluated the antinociceptive effects of CT on orofacial nociception in mice and investigated the central pathway involved in the effect. Male Swiss mice were pre-treated with CT (25, 50 and ...
Gasparini Giorgio - - 2012
ABSTRACT: INTRODUCTION: Insulin-like growth factor I (IGF-I) regulates articular cartilage homeostasis. During osteoarthritis (OA), the anabolic responses of chondrocytes to IGF-I are likely to be prevented by the enhanced production of IGF binding proteins (IGFBPs), especially IGFBP-3. The aim of this study is to evaluate whether the architectural transcription factor ...
Bansal Minakshi - - 2012
Abstract Data on Quality of life (QOL) specifically in maintenance therapy of acute lymphoblastic leukemia (ALL) is minimal. This study was done to assess varied items listed in domains of QOL (physical, emotional, social and school health domains) of children with ALL during maintenance therapy, and compare the same with ...
Vila Jordi J University of Barcelona, Hospital Clinic, School of Medicine, Department of Clinical Microbiology, Villarroel 170, Barcelona, Spain. - - 2012
Although the clinical importance of Acinetobacter pittii and Acinetobacter nosocomialis has increased in the nosocomial setting in the last decade, infections caused by Acinetobacter baumannii still have the highest clinical relevance. The most important features of this latter species are the ability to persist in the hospital environment and the ...
Sánchez-Solana Beatriz B Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, George Washington University, Washington, DC 20037, - - 2012
Tissue factor (TF) is a cell-surface glycoprotein responsible for initiating the coagulation cascade. Besides its role in homeostasis, studies have shown the implication of TF in embryonic development, cancer-related events, and inflammation via coagulation-dependent and -independent (signaling) mechanisms. Tissue factor pathway inhibitor (TFPI) plays an important role in regulating TF-initiated ...
Vargovic Peter - - 2012
Catecholamines (CATs), the major regulator of lipolysis in adipose tissue, are produced mainly by the sympathoadrenal system (SAS). However, recent studies report endogenous CAT production in adipocytes themselves. This study investigated the effects of single and repeated (7 to 14 times) immobilization (IMO) stress on CAT production in various fat ...
Chen Qiang Q Department of Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, - - 2013
Deleted in colorectal cancer (DCC) is a receptor for the axon guidance cues netrin-1 and draxin. The interactions between these guidance cues and DCC play a key role in the development of the nervous system. In the present study, we reveal the crystal structure of the N-terminal four Ig-like domains ...
Kimura Chiharu - - 2012
Abstract To investigate the relation between the severity of hypoxic changes and oxidative DNA damage in the placenta of early and late-onset preeclampic women and FGR, serum parameters of oxidative stress, placental hypoxic change, and oxidative DNA damage were determined.We examined 10 participants with uncomplicated pregnancies, 13 with early-onset and ...
Getz Anne E AE Department of Otolaryngology-Head and Neck Surgery, Washington University, St. Louis, MO 63110, USA. - - 2013
Lateralization of the middle turbinate is a commonly cited factor leading to failure of functional endoscopic sinus surgery (FESS). Inadequate medialization during FESS may require repeat intraoperative attempts, and may lead to destabilization and mucosal trauma. A novel technique is described that increases middle meatal area and provides more definitive ...
Pickering Andrew M AM Ethel Percy Andrus Gerontology Center of Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089-0191, - - 2013
In mammalian cells, hydrogen peroxide (H(2)O(2))-induced adaptation to oxidative stress is strongly dependent on an Nrf2 transcription factor-mediated increase in the 20S proteasome. Here, we report that both Caenorhabditis elegans nematode worms and Drosophila melanogaster fruit flies are also capable of adapting to oxidative stress with H(2)O(2) pre-treatment. As in ...
Watanabe Ippei - - 2013
Indoxyl sulfate (IS) is a uremic toxin that causes renal injury, but little is known about its adverse effects on the cardiovascular system. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates adaptive and toxic responses in cells. Recent studies identified IS as an endogenous agonist for ...
Young Bessie A BA Veterans Affairs Puget Sound Health Care System, Kidney Research Institute, Division of Nephrology, University of Washington, Seattle, Washington 98108, USA. - - 2012
Home hemodialysis (HD) is an underused dialysis modality in the United States, even though it provides an efficient and probably cost-effective way to provide more frequent or longer dialysis. With the advent of newer home HD systems that are easier for patients to learn, use, and maintain, patient and provider ...
Aikawa Kohsuke - - 2012
All enantiopure atropisomeric (atropos) ligands essentially require enantiomeric resolution or synthetic transformation from a chiral pool. In sharp contrast, the use of tropos (chirally flexible) ligands, which are highly modular, versatile, and easy to synthesize without enantiomeric resolution, has recently been the topic of much interest in asymmetric catalysis. Racemic ...
Mohammad Shahid S Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama-city, Toyama 930-8555, - - 2012
Cholecystokinin (CCK) and its receptor subtypes CCK-1 and -2 have diverse homeostatic functions. CCK-1 and -2 receptors share a common phosphatidylinositol signaling pathway, yet little is known regarding their possible functional coupling. We focused on CCK-mediated Ca(2+) signaling in parvocellular paraventricular nucleus (PVN) cells, which control satiety and other autonomic ...
Gada Hemal - - 2012
BACKGROUND: In the setting of chronic stable angina, successful percutaneous coronary intervention (PCI) of chronic total occlusions (CTO) has been shown to produce significant symptom improvement with some evidence for survival benefit. However, the economic basis for this procedure has not been established compared with optimal medical treatment (OMT) of ...
Xing Jianguo - - 2012
Context: Dracocephalum moldavica Linn (Labiatae) is one of the ethnomedicinal drugs of Uygur in Xinjiang, China. This herb is mainly used in treating cardiovascular diseases, such as atherosclerosis. However, the mechanism of pharmacological activity of D. moldavica has been poorly studied. Objective: To explore the pharmacological mechanism of D. moldavica ...
Xu Xiaojian X Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, - - 2012
Soluble guanylyl cyclase (sGC) is the principal receptor for nitric oxide (NO) and crucial for the control of various physiological functions. The β1 subunit of sGC is obligatory for the biological stability and activity of the sGC heterodimer. MicroRNAs (miRNAs) are important regulators of gene expression and exert great influences ...
Serisier Dj - - 2012
SUMMARY AT A GLANCE: Australasian emergency and respiratory physicians infrequently use the Pneumonia Severity Index (PSI) and are unable to apply it accurately. Two physician groups differed in their relative abilities to apply PSI and CURB65, suggesting fragmented guideline dissemination. Australasian guidelines should promote a simple, coordinated pneumonia severity assessment ...
Menezes Cn - - 2012
OBJECTIVES: Stavudine is being phased out because of its mitochondrial toxicity and tenofovir (TDF) is recommended as part of first-line highly active antiretroviral therapy (HAART) in South Africa. A prospective, open-label, randomized controlled trial comparing standard- and low-dose stavudine with TDF was performed to assess early differences in adipocyte mtDNA ...
Deasy Conor - - 2012
AIM: We describe improved reporting of paediatric out-of-hospital cardiac arrest (OHCA) by adding coronial findings to a cardiac arrest registry. METHODS: Non-traumatic OHCA occurring in paediatric patients aged less than 16 years were identified using the Victorian Ambulance Cardiac Arrest Registry and available coronial findings reviewed. RESULTS: Between the years ...
Stewart Mark G - - 2012
We evaluate, for the U.S. case, the costs and benefits of three security measures designed to reduce the likelihood of a direct replication of the 9/11 terrorist attacks. To do so, we assess risk reduction, losses, and security costs in the context of the full set of security layers. The ...
De Jaco Antonella - - 2012
The α/β-hydrolase fold super-family of proteins is composed of structurally related members that, despite great diversity in their catalytic, recognition, adhesion and chaperone functions, share a common fold governed by homologous residues and conserved disulfide bridges. Non-synonymous single nucleotide polymorphisms, within the α/β-hydrolase fold domain, in different family members have ...
Hinchcliff Reece - - 2012
AIMS: To systematically identify and synthesise health service accreditation literature. METHODS: A systematic identification and narrative synthesis of health service accreditation literature published prior to 2012 were conducted. The search identified 122 empirical studies that examined either the processes or impacts of accreditation programmes. Study components were recorded, including: dates ...
Busby Ben - - 2012
Facultative pathogens have extremely dynamic pan-genomes, to a large extent derived from bacteriophages and other mobile elements. We developed a simple approach to identify phage-derived genomic islands and apply it to show that pathogens from diverse bacterial genera are significantly enriched in clustered phage-derived genes compared with related benign strains. ...
Codony-Servat Jordi - - 2013
Previous work showed that the NF-κB survival pathway is activated by docetaxel (D) and contributes to D resistance in prostate cancer. In this study we aimed to investigate the dynamics of the relationship between NF-κB and IL-6 in the shift from D-naive castration-resistant prostate cancer (CRPC) to D-resistance in patients ...
Rosenberger Hale Erica Lyn - - 2012
BACKGROUND: Physical inactivity contributes to metabolic syndrome (MetS) in overweight/obesity. However, little is known about this relationship in prediabetes. METHODS: The study purpose is to examine relationships between physical activity (PA) and MetS in prediabetes. The Healthy Living Partnerships to Prevent Diabetes tested a community translation of the Diabetes Prevention ...
Bachy Charles C Unité d'Ecologie, Systématique et Evolution, CNRS UMR 8079, Université Paris-Sud, Orsay, - - 2013
Deep-sequencing technologies are becoming nearly routine to describe microbial community composition in environmental samples. The 18S ribosomal DNA (rDNA) pyrosequencing has revealed a vast diversity of infrequent sequences, leading to the proposition of the existence of an extremely diverse microbial 'rare biosphere'. Although rare microbes no doubt exist, critical views ...
Shukla Varsha V Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, - - 2013
Alzheimer's disease (AD), one of the leading neurodegenerative disorders of older adults, which causes major socioeconomic burdens globally, lacks effective therapeutics without significant side effects. Besides the hallmark pathology of amyloid plaques and neurofibrillary tangles (NFTs), it has been reported that cyclin-dependent kinase 5 (Cdk5), a critical neuronal kinase, is ...
Zhou Tao - - 2012
Putting the DNA in dendrimers: A strategy to swiftly prepare DNA dendrimers based solely on DNA self-assembly is presented. This technique produces highly pure DNA dendrimers with an excellent yield of high generation dendrimers. The incorporation of molecular motors (i-motifs) into the DNA dendrimers allows for a change in size ...
Wang Jay Ching Chieh - - 2012
BACKGROUND: There is a need to find an animal model to study new medications to improve mucosal wound healing after functional endoscopic sinus surgery (FESS). Current literature suggests swine as a potential candidate. The lack of information correlating swine computer tomography (CT) and endoscopic sinonasal anatomy prompted us to investigate ...
Legrand Baptiste - - 2012
BAC for more: A constrained bicyclic building block with urea linkages is an efficient combination for the formation of a highly rigid helical system. This type of bicyclic amino carbamoyl (BAC) foldamer was studied both in solution and in the solid state. A robust H-bond (dotted line) network was found ...
Li Shiming - - 2012
Tea is the most popular flavored and functional drink worldwide. The nutritional value of tea is mostly from the tea polyphenols that are reported to possess a broad spectrum of biological activities, including anti-oxidant properties, reduction of various cancers, inhibition of inflammation, and protective effects against diabetes, hyperlipidemia and obesity. ...
Glekas George D GD Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, - - 2012
Bacillus subtilis can perform chemotaxis toward all 20 L-amino acids normally found in proteins. Loss of a single chemoreceptor, McpC, was previously found to reduce chemotaxis to 19 of these amino acids. In this study, we investigated the amino acid-sensing mechanism of McpC. We show that McpC alone can support ...
Cregten-Escobar Patricia - - 2012
Introduction.  Subcutaneous mastectomy is the first surgical procedure to be completed by female to male transsexuals after appropriate mental health and endocrine therapy. Objectives of subcutaneous mastectomy in this group are to masculinize the chest by the removal of breast tissue and skin excess, reduction and proper positioning of the ...
Wei Wei - - 2012
We have identified variants present in high-coverage complete sequences of 36 diverse human Y chromosomes from Africa, Europe, South Asia, East Asia and the Americas representing eight major haplogroups. After restricting our analysis to 8.97 Mb of unique male-specific Y sequence, we identified 6,662 high-confidence variants including SNPs, MNPs and ...
Chen Li D - - 2012
Receptors that exhibit high selectivity are essential for potentiometric cyanide sensors. Therefore, CN- binding to metallotetraphenylporphyrins with different metal centers (i.e, Co(II), Co(III) Zn(II), Ni(II), Cu(II) and Fe(III)) was investigated. All these metalloporphyrins were found to function as neutral ionophores. Co(III) and Fe(III) tetraphenylporphyrins with their positive charges seemed likely ...
Kurt Zohre - - 2012
Plumes of contaminated groundwater often pass through an oxic/anoxic interface when they discharge into surface water bodies. We tested the hypothesis that contaminants recalcitrant under anaerobic conditions but degradable under aerobic conditions can be biodegraded at the interface resulting in the protection of the overlying water. Flow through columns containing ...
Hill Eric H - - 2012
A novel class of phenylene ethynylene polyelectrolyte oligomers (OPEs) has been found to be effective biocidal agents against a variety of pathogens. The mechanism of attack is not yet fully understood. Recent studies have shown that OPEs cause catastrophic damage to large unilamellar vesicles. This study uses classical molecular dynamics ...
Cheng Yu-Ting - - 2012
Pores for thought: Chemical liquid deposition of silica onto ZSM-5 catalysts led to smaller pore openings that resulted in >90 % selectivity for p-xylene over the other xylenes in the catalytic fast pyrolysis of furan and 2-methylfuran. The p-xylene selectivity increased from 51 % with gallium spray-dried ZSM-5 to 72 % with a ...
Takeuchi Akito - - 2012
Objectives: The purpose of this study was to develop an analytical method for the simultaneous determination of inorganic arsenic [As (III) and As (V)] and monomethylarsonic acid (MMA) in urine by gas chromatography-mass spectrometry (GC-MS) for the biological monitoring of exposure to inorganic arsenic. Methods: Arsenic compounds (after reduction of ...
Chebli Youssef - - 2012
The pollen tube is a cellular protuberance formed by the pollen grain, or male gametophyte, in flowering plants. Its principal metabolic activity is the synthesis and assembly of cell wall material, which must be precisely coordinated to sustain the characteristic rapid growth rate and to ensure geometrically correct and efficient ...
Quarto Natalina - - 2012
Marfan syndrome (MFS) is a hereditary disease caused by mutations in the gene encoding Fibrillin-1 (FBN1) and characterized by a number of skeletal abnormalities, aortic root dilatation and sometimes ectopia lentis. Although the molecular pathogenesis of MFS was attributed initially to a structural weakness of the fibrillin-rich microfibrils within the ...
Moon Youngtaek - - 2012
Concise and selective: The title one-pot sequence allows formation of the enone functionality and subsequent cross-coupling. The process provides access to highly functionalized cyclic enolones and enaminones from readily accessible β-heteroatom-substituted cyclic ketones.
Sundd Monica - - 2012
Ubiquitin interacts with numerous domains and motifs in its lifetime that vary in structure but bind the same hydrophobic patch. To identify the structural features of ubiquitin that make it an exceptional protein-protein interaction partner, we have studied the interaction of ubiquitin with the signal transducing adaptor molecule-1 ubiquitin interacting ...
Park Indal - - 2012
Abstract Purpose: The aim of this study was to investigate the factors that affect the precipitation of vancomycin and ceftazidime which are currently used in intravitreal injections for infectious endophthalmitis. Methods: The minimum concentration required for precipitation of the 2 antibiotics was estimated by 2-fold dilution. In addition, the amount ...
Greiner Rinaldo - - 2012
Lab-on-a-chip (LOC) technology has blossomed into a major new technology fundamentally influencing the sciences of life and nature. From a systemic point of view however, microfluidics is still in its infancy. Here, we present the concept of a microfluidic central processing unit (CPU) which shows remarkable similarities to early electronic ...
Haque Zeba - - 2012
Leptin, originally identified as an anti-obesity hormone, also has an important role in the regulation of mood and emotion. The present study was designed to monitor effects of injected leptin on immobilization stress-induced anorexia, behavioral deficits and plasma corticosterone secretion in rats. Exposure to 2h immobilization stress decreased food intake ...
Giloteaux Ludovic L Department of Microbiology, University of Massachusetts, Amherst, MA 01003-9298, USA. - - 2013
The possibility of arsenic release and the potential role of Geobacter in arsenic biogeochemistry during in situ uranium bioremediation was investigated because increased availability of organic matter has been associated with substantial releases of arsenic in other subsurface environments. In a field experiment conducted at the Rifle, CO study site, ...
Cheung Tan To - - 2012
BACKGROUND: Liver resection provides one of the best oncological outcomes for liver metastases in patients with colorectal cancer. However, long-term results concerning laparoscopic resection versus open hepatectomy for stage IV colon cancer are still limited. The aim of this study is to compare the survival outcome of laparoscopic liver resection ...
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