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Results 501 - 550 of 2847
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Willems-Jones Amber - - 2012
What's known on the subject? and What does the study add? The risk of developing aggressive prostate cancer is increased for men carrying a pathogenic germline mutation in BRCA2. An earlier study by the Kathleen Cuningham Consortium for Research into Familial Breast Cancer showed that BRCA2 mutation carriers displayed a ...
Yu H - - 2012
Objective The aim of this study was to examine the number of hot flush symptom-free days in symptomatic postmenopausal women treated with bazedoxifene/conjugated estrogens (BZA/CE). Methods In this 12-week, randomized, double-blind, placebo-controlled, phase-3 study, 322 postmenopausal women aged 40-65 years with an intact uterus who had ≥ seven moderate-to-severe daily ...
Osborne Olivia Joanna - - 2012
Abstract Manufactured metal (oxide) nanoparticles are entering the aquatic environment with little understanding on their potential health impacts for exposed organisms. Adopting an integrative approach, we investigated effects of particle size and coating on biological responses for two of the most commonly used metal (oxide) nanoscale particles, silver (Ag) and ...
Yildiz Saliha Handan - - 2012
Apolipoprotein E (ApoE) gene polymorphisms are thought to be the most important genetic risk factor in the pathogenesis of late onset and sporadic Alzheimer's disease (AD). Moreover, interleukin-1α (IL-1α) is found to be associated with the pathogenesis of AD. In this research, ε2, ε3, and ε4 polymorphisms of ApoE gene ...
Moss Joshua D JD Department of Medicine, Section of Cardiology, University of Chicago, Chicago, Illinois 60614, USA. - - 2012
BACKGround : Left lateral accessory pathway (AP) location along the mitral annulus (MA) can influence ablation strategy, including choice of a transseptal or retrograde aortic approach and the use of deflectable sheaths and/or bidirectional catheters. We aimed to develop electrocardiographic (ECG) criteria to accurately localize a left lateral AP, hypothesizing ...
Granado-Lorencio F - - 2012
Intoxication from vitamin D supplements has been rarely reported, but nowadays, it occurs more frequently. The presence of the C-3 epimer of 25-hydroxyvitamin D(3) (3-epi-25-OH-D(3)) is highly prevalent in adults, although there is little information regarding its in vivo relevance, if any, especially under pathological conditions. Our aim was to ...
Grünwald G K - - 2012
In this study, we determined the in vitro and in vivo efficacy of sodium iodide symporter (NIS) gene transfer and the therapeutic potential of oncolytic virotherapy combined with radioiodine therapy using a conditionally replicating oncolytic adenovirus. For this purpose, we used a replication-selective adenovirus in which the E1a gene is ...
Liu Kai - - 2012
Abstract Induced pluripotent stem cells (iPSCs) can be artificially reprogrammed from somatic cells by overexpression of exogenous transcription factors. The pig has increasingly become an important large animal model for preclinical tests and studies of human diseases; thus, the generation of porcine iPSCs will facilitate research into the efficacy and ...
La Kim Eun - - 2012
A new cyclic tetrapeptide (1), along with known congeners (2 and 3), was isolated from the fungus Phoma sp. derived from the giant jellyfish Nemopilema nomurai. The absolute configuration of 1 was determined using the modified Mosher's method and Marfey's method. Compound 1 displayed a weak suppressive effect on the ...
Hajjaji Nawale - - 2012
Body weight loss during the course of cancer disease has been associated with poor prognosis. Beside cancer-associated cachexia, weight loss can also result from chemotherapy. This work explored whether a model of mammary tumors in female Sprague Dawley rats could be appropriate to study the effect of doxorubicin on body ...
Grassian Alexandra R AR Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, - - 2012
Mutations in the genes encoding isocitrate dehydrogenase 1 and 2 (IDH1/2) occur in a variety of tumor types, resulting in production of the proposed oncometabolite, 2-hydroxyglutarate (2-HG). How mutant IDH and 2-HG alter signaling pathways to promote cancer, however, remains unclear. Additionally, there exist relatively few cell lines with IDH ...
Wängler Björn - - 2012
Proteins previously derivatized with the cross-coupling reagent sulfo-SMCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxy-succinimide ester sodium salt) can be easily labeled in high radiochemical yields with the silicon-fluoride acceptor (SiFA) reagent [(18)F]SiFA-SH, obtained via isotopic exchange, by thiol-maleimide coupling chemistry (n = 10). The specific activity of SiFA-SH obtained in a one-step labeling ...
Clapin Helen F - - 2012
Epidemiological evidence suggests that folate may lower the risk of colorectal cancer (CRC) although studies have been inconsistent and some have indicated differences in the effects of naturally occurring dietary folate and the synthetic form of this vitamin, folic acid. Most studies to date have considered CRC as a single ...
Saidun Salilah - - 2012
Visual recording of human subjects is commonly used in biomedical disciplines for clinical, research, legal, academic and even personal purposes. Guidelines on practice standards of biomedical recording have been issued by certain health authorities, associations and journals, but none of the literature discusses this from an Islamic perspective. This article ...
Karaplis Andrew C AC McGill University, Montréal, Québec, Canada H9X - - 2012
We have previously confirmed a paradoxical mineralizing enthesopathy as a hallmark of X-linked hypophosphatemia. X-linked hypophosphatemia is the most common of the phosphate-wasting disorders mediated by elevated fibroblast growth factor 23 (FGF23) and occurs as a consequence of inactivating mutations of the PHEX gene product. Despite childhood management of the ...
Moorin Rachael - - 2012
OBJECTIVES: Controversy persists over the relationships between health care expenditure, time-to-death and age, undermining attempts to generate convincing predictions for policy. This paper explores the relationships between time-to-death (TTD), age and health care expenditure for Australian Medicare-funded, out-of-hospital services in the last five years of life, assessing if the relationship ...
Duan Zhijian Z Cancer Center/Basic Sciences, University of California at Davis, Sacramento, California 95817, - - 2013
Chromatin regulators ANCCA and EZH2 are overexpressed in prostate cancer and play crucial roles in androgen-stimulated and castration-refractory prostate tumor growth and survival. However, how their expression is regulated in the tumors and whether they play a role in prostate development remains unclear. Prostate tissue from different developmental stages of ...
Karasavvas Nicos - - 2012
The Thai Phase III clinical trial (RV144) showed modest efficacy in preventing HIV-1 acquisition. Plasma collected from HIV-1-uninfected trial participants completing all injections with ALVAC-HIV (vCP1521) prime and AIDSVAX B/E boost were tested for antibody responses against HIV-1 gp120 envelope (Env). Peptide microarray analysis from six HIV-1 subtypes and group ...
Kenwright Alan M - - 2012
The preparation of a number of alkyl and alkoxy derivatives of pentacyclo[5.4.0.0(2,6) .0(3,10) .0(5,9) ]undecane-8,11-dione derivatives utilising a cheap, practical, low energy, 'green', single-pass continuous flow photochemical reactor is reported. Their (1)  H and (13) C NMR spectra are fully assigned, revealing some general characteristics not previously reported for this ...
Medina Bethan B Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, United - - 2012
The ubiquitin-proteasome system is essential for maintaining a functional cell. Not only does it remove incorrectly folded proteins, it also regulates protein levels to ensure their appropriate spatial and temporal distribution. Proteins marked for degradation by the addition of Lys(48)-linked ubiquitin (Ub) chains are recognized by shuttle factors and transported ...
Kane Stephen R - - 2012
Abstract The habitable zone for a given star describes the range of circumstellar distances from the star within which a planet could have liquid water on its surface, which depends upon the stellar properties. Here we describe the development of the habitable zone concept, its application to our own solar ...
Rabinowich Liane - - 2012
OBJECTIVE: Previous reports on the association between statin use and venous thromboembolism (VTE) did not examine patient adherence to medications, thus their applicability in a real life setting is questionable. Our objective was to investigate the association between the use of statins and incidence of first ever idiopathic VTE. DESIGN: ...
Guasch Judith - - 2012
An organic switch: An open-shell dyad, consisting of an electron acceptor perchlorotriphenylmethyl radical unit linked to an electron π-donor tetrathiafulvalene unit through a vinylene π-bridge, was synthesized. The self-assembly of the dyad in solution induced by its intramolecular electron transfer was studied.
Forouzesh Elham - - 2012
Turgor pressure in plant cells is involved in many important processes. While stable and normal turgor pressure is required for healthy growth of a plant, changes in turgor pressure are indicative of changes taking place within the plant tissue. The ability to quantify turgor pressure of plant cells in vivo ...
Vilmar A C - - 2012
BackgroundPlatinum-based doublets (PBDs) remain the cornerstone of treatment in non-small-cell lung cancer (NSCLC) and may include gemcitabine. A biomarker predicting sensitivity to this antimetabolite would represent a major step forward. Accordingly, we explored the predictive role of ribonucleotide reductase subunit M (RRM1) in advanced NSCLC.Patients and methodsA total of 443 ...
Gregório Sílvia F - - 2012
In addition to high drinking rates, processing of intestinal fluid is essential for osmoregulation in marine fish. This study analyzed the long-term response of the sea bream (Sparus aurata L.) to relevant changes of external salinity 12, 35 and 55ppt focusing on the anterior intestine and in the less often ...
Wen Tianlong - - 2012
Large area dense hole arrays with feature size ~ 10 nm were generated using self-assembled monolayers of nanoparticles as etch masks. To fabricate the hole arrays, monolayers of nanoparticles were irradiated by electron beam to turn surfactants into amorphous carbon, treated by acid to remove the nanoparticle cores, and then ...
Vanholme Ruben - - 2012
CONTENTS: Summary    1 I. Introduction    2 II. Phenolic metabolism    2 III. Lignin biosynthesis and structure    6 IV. Alternative lignin monomers for biofuel applications    8 V. Candidate alternative monolignols in biomimetic systems 14 VI. From phenolic profiling to lignomics 15 VII. Phenolic pathway engineering towards alternative monolignols 16 Acknowledgements 17 References ...
Eskenazi Terry - - 2012
Social influences on action and memory are well established. However, it is unknown how acting together affects the incidental encoding of information. The present study asked whether coactors encode information that is relevant to a partner's task, but irrelevant to their own task. In Experiment 1, participants performed a categorization ...
Tamminen Jakke - - 2012
We sought to establish whether novel words can become integrated into existing semantic networks by teaching participants new meaningful words and then using these new words as primes in two semantic priming experiments, in which participants carried out a lexical decision task to familiar words. Importantly, at no point in ...
Kir Serkan S Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, - - 2012
Fibroblast growth factor 19 (FGF19) is a postprandial enterokine induced by the nuclear bile acid receptor, FXR, in ileum. FGF19 inhibits bile acid synthesis in liver through transcriptional repression of cholesterol 7α-hydroxylase (CYP7A1) via a mechanism involving the nuclear receptor SHP. Here, in a series of loss-of-function studies, we show ...
Schmieder Roland E - - 2012
Hypertension is the most prevalent, treatable cause of cardiovascular (CV) disease. Patients with hypertension and one or more comorbidities increasingly form a significant part of the primary care practitioner's caseload. The emphasis on intensive blood pressure (BP) lowering has softened, encouraging any degree of BP lowering, since any fall in ...
Wängler Carmen - - 2012
Here we present a procedure to label peptides with the positron-emitting radioisotope fluorine-18 ((18)F) using the silicon-fluoride acceptor (SiFA) labeling methodology. Positron emission tomography (PET) has gained high importance in noninvasive imaging of various diseases over the past decades, and thus new specific imaging probes for PET imaging, especially those ...
Culvenor Adam G - - 2012
Patellofemoral joint (PFJ) osteoarthritis (OA) is a prevalent disease capable of being a potent source of knee symptoms. Although anterior cruciate ligament (ACL) injury and reconstruction (ACLR) are well-established risk factors for the development of tibiofemoral joint OA, PFJ OA after ACL reconstruction has gone largely unrecognised. This is despite ...
Shoaib Muhammad - - 2013
We have developed an approach termed PUB-NChIP (proximity utilizing biotinylation with native ChIP) to purify and study the protein composition of chromatin in proximity to a nuclear protein of interest. It is based on coexpression of (1) a protein of interest, fused with the bacterial biotin ligase BirA, together with ...
Reid Rory C - - 2012
Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for hypersexual disorder (HD) have been proposed to capture symptoms reported by patients seeking help for out-of-control sexual behavior. The proposed criteria created by the DSM-5 Work Group on Sexual and Gender Identity Disorders require evaluation in a formal ...
Fouks Bertrand - - 2012
Foraging is a result of innate and acquired mechanisms, and is optimized in order to increase fitness. During foraging an animal faces many threats - such as predation and infection. The uptake of parasites and diseases while foraging is common and an individual should be adapted to detect and avoid ...
Cnossen Arjen - - 2012
Driving molecular rotary motors using visible light (530-550 nm) instead of UV light was achieved using palladium tetraphenylporphyrin as a triplet sensitizer. Visible light driven rotation was confirmed by UV/vis absorption, circular dichroism and 1H NMR spectroscopy and the rotation was confirmed to be unidirectional and with similar photostationary states, ...
Sylvester Deborah Claire - - 2012
BACKGROUND: The management of chronic rhinosinusitis is based on a trial of "maximal medical therapy" before surgery is considered. Ear-Nose-Throat (ENT) UK consultant members were surveyed to determine the role and variability of UK-wide practices. METHODS: A survey was posted to all ENT UK consultant members (n = 603). This ...
Tanaka Kyoko - - 2012
Glycolipid and transporter protein gene expression in ovarian serous carcinoma-derived 2008 cells, and their paclitaxel-resistant P×2 and cisplatin-resistant C13 forms was examined to confirm the previous finding, i.e., that it was characteristically altered in anticancer drug-resistant cells established on continuous cultivation of ovarian carcinoma-derived KF28 cells in the different anticancer ...
Sánchez-Vallet Andrea A Centro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid, Campus de Montegancedo, E-28223 Madrid, - - 2012
Plant resistance to necrotrophic fungi is regulated by a complex set of signaling pathways that includes those mediated by the hormones salicylic acid (SA), ethylene (ET), jasmonic acid (JA), and abscisic acid (ABA). The role of ABA in plant resistance remains controversial, as positive and negative regulatory functions have been ...
Nelius Thomas T Department of Urology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430-6591, - - 2013
In this study, we investigated the capacity of pigment epithelium-derived factor (PEDF) to modulate the recruitment and the differentiation of monocytes/macrophages both in vitro and in human prostate. Using Boyden chambers, we assessed PEDF effect on the migration of monocytes and chemically activated RAW 264.7 macrophages. Normal, prostatitis, and prostate ...
Pompeo Matthew - - 2012
No migration? No problem! A series of new N-heterocyclic carbene based Pd complexes has been created and evaluated in the Negishi cross-coupling of aryl- and heteroaryl chlorides, bromides, and triflates with a variety of secondary alkylzinc reagents. The direct elimination product is nearly exclusively formed; in most examples there is ...
Luiz Luz Leiria Tiago - - 2012
Background: To describe the association between body mass index (BMI) and a positive response during a head-up tilt test (HUT) in patients referred for an investigation of syncope. Methods: Observational study of patients referred for the diagnostic evaluation of syncope. Patients were divided into four groups according to their BMI: ...
Ait-Ouazzou Abdenour - - 2012
AIMS: To study the mechanism of bacterial inactivation by carvacrol and the influence of genetic and environmental factors in its antimicrobial activity. METHODS AND RESULTS: In general, bacterial inactivation by carvacrol was higher in the Gram-positive Listeria monocytogenes than in the Gram-negative Escherichia coli and at acidic pH. At pH ...
Wu Yili - - 2012
Abnormal expression of regulator of calcineurin 1 (RCAN1) has been implicated in Alzheimer's disease (AD) and Down's syndrome (DS). There are two major isoforms of RCAN1, isoforms 1 and 4. RCAN1 isoform 1 is predominantly expressed in the brain, particularly in neurons. In this report, we showed that there are ...
Graham Erin R - - 2012
Each spring, North American spotted salamander (Ambystoma maculatum) females each lay hundreds of eggs in shallow pools of water. Eggs are surrounded by jelly layers and deposited as large gelatinous masses. Following deposition, masses are penetrated by a mutualistic green alga, Oophila amblystomatis, which enters individual egg capsules, proliferates, and ...
Massey Mark Kieran - - 2012
Langmuir-Blodgett deposition has been used to form thin film networks of both metallic and semiconducting single-walled carbon nanotubes. These have been investigated to understand their physical, optical and morphological properties. The electrical conductivities over the temperature range 80 K to 350 K and across electrode spacings of 220 nm and ...
Ma Ya-Tuan - - 2012
Several series of forty-five acetophenone derivatives bearing various alkyl or benzyl substituents were conveniently synthesized and their structures characterized by (1) H and (13) C NMR spectroscopy, HRMS and single crystal X-ray analysis. Their in vitro antifungal activities against a panel of phytopathogenic fungi were evaluated by mycelial growth rate ...
Li Zhen - - 2012
Myc is a pleiotropic transcription factor that is involved in many cellular activities relevant to carcinogenesis including hepatocarcinogenesis. The zebrafish has been increasingly used to model human diseases and it is particularly valuable to help identify common and conserved molecular mechanisms in vertebrates. Here we generated a liver tumor model ...
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