Search Results
Results 451 - 500 of 2845
< 5 6 7 8 9 10 11 12 13 14 15 >
Semprini Gabriele - - 2012
ABSTRACT The authors' aim was to compare interhemispheric transfer time between 2 groups: highly skilled sportsmen and control subjects. Left- and right-handed individuals were included in the study. The Poffenberger paradigm was used to measure the crossed-uncrossed difference, representing the time to transfer information from one hemisphere to the other. ...
Verbrugge Frederik Hendrik - - 2012
OBJECTIVE: To investigate whether time from onset of heart failure signs and/or symptoms (ie, progression to stage C/D heart failure) until implantation affects reverse remodelling and clinical outcome after cardiac resynchronisation therapy (CRT). DESIGN: Cohort study of consecutive CRT patients, implanted between 1 October 2008 and 30 April 2011. SETTING: ...
Bobick Brent E - - 2012
In humans, loss of SHOX gene function is responsible for the mesomelic short stature characteristic of Turner syndrome, Leri-Weill dyschondrosteosis, and Langer dysplasia. In a mouse model of SHOX deficiency, Prrx1-Cre-driven limb-specific deletion of the paralogous gene Shox2 results in severe rhizomelia. In this study, we show that Col2a1-Cre-driven deletion ...
Wosnitza Anne - - 2012
Legged locomotion is the most common behavior of terrestrial animals and it is assumed to have become highly optimized during evolution. Quadrupeds, for instance, use distinct gaits which are optimal with regard to metabolic cost and have characteristic kinematic features and patterns of inter-leg coordination. In insects, the situation is ...
Humenny William J - - 2012
Ring the changes: The cycloaddition of nitrones with 1-carboallyloxy-1-carbomethoxycyclopropanes yields tetrahydro-1,2-oxazines, which in turn undergo a Tsuji dehydrocarbonylation to give dihydro-1,2-oxazines (see scheme; dba=dibenzylideneacetone). Addition of base to this reaction mixture results in clean conversion to pyrroles. The result is a flexible three-component strategy for the synthesis of tetrasubstituted pyrroles.
Sehn Francisléa - - 2012
Objective.  Catastrophizing is a maladaptive response to pain and is one of the factors that contribute to the chronicity of some pain syndromes. The Pain Catastrophizing Scale (PCS) assists both treatment planning and outcome assessment. Its use is limited in Portuguese-speaking countries because of the lack of a validated translated ...
Hopfer Helene - - 2012
Californian Chardonnay was stored in five different wine packaging configurations at three different temperatures for a period of three months to study the combined packaging temperature effects on the sensory and chemical properties of the wines. A trained descriptive panel evaluated aroma, taste, mouthfeel and color, and the results were ...
Kim Tae-Won - - 2012
Context: The root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae) has been widely studied for its hepatoprotective effects against various hepatotoxicants. Objective: The present study evaluated the protective effect of the standardized aqueous extract of P. grandiflorum (BC703) on cholestasis-induced hepatic injury in mice. Materials and methods: BC703 is a ...
Hirakawa Yoshihisa - - 2012
In plants, many nucleus-encoded proteins are targeted to both mitochondria and plastids, and this process is generally mediated by ambiguous N-terminal targeting sequences that are recognized by receptors on both organelles. In many algae, however, plastids were acquired by secondarily engulfing green or red algae, which were retained within the ...
Ansari Daniel - - 2012
Abstract Management of colorectal liver metastases (CRLM) has dramatically changed during the last decade and has now become more multimodal and aggressive, including the use of downstaging chemotherapy, portal vein embolization to increase the function of the liver remnant or both in combination. Radiofrequency ablation is also an option in ...
Wang Yen-Feng - - 2012
Background:Osmophobia is an under-investigated associated symptom in migraine.Objective:To evaluate the clinical correlates and diagnostic utility of osmophobia.Methods:Adult patients with migraine (with or without aura), probable migraine (PM), tension-type headache (TTH), and cluster headache (CH) were recruited retrospectively from our headache registration system. Migraine patients with and without osmophobia were compared. ...
Nygård Yngve - - 2012
Abstract Objective. The prostate cancer gene 3 (PCA3) score in urine is a promising biomarker for prostate cancer. Real-time elastography (RTE) is a well-documented ultrasound modality. The objective of this study was to evaluate the ability to detect significant cancer foci in the prostate with these methods alone and in ...
Zheng Haimei - - 2012
We report on electron beam manipulation and simultaneous transmission electron microscopy imaging of gold nanoparticle movements in an environmental cell. Nanoparticles are trapped with the beam and move dynamically towards the location with higher electron density. Their global movements follow the beam positions. Analysis on the trajectories of nanoparticle movements ...
Maksymowych Walter P - - 2012
ABSTRACT: INTRODUCTION: Inflammation associated with synovial expression of tumour necrosis factor alpha (TNFalpha) is a recognised feature of osteoarthritis (OA), though no studies have yet reported beneficial effects of anti-TNFalpha therapy on clinical manifestations of inflammation in OA. METHODS: We conducted an open label evaluation of adalimumab over 12 weeks ...
Wanniarachchi Sarath - - 2012
A series of rhodium(III) complexes of the redox-active ligand, H(L = bis(4-methyl-2-(1H-pyrazol-1-yl)phenyl)amido), was prepared, and the electronic properties were studied. Thus, heating an ethanol solution of commercial RhCl(3)·3H(2)O with H(L) results in the precipitation of insoluble [H(L)]RhCl(3), 1. The reaction of a methanol suspension of [H(L)]RhCl(3) with NEt(4)OH causes ligand ...
Rezanejad Habib - - 2012
Abstract Pluripotent stem cells (PSCs) have the potential to differentiate into many cell types and therefore can be a valuable source for cell therapy. Embryonic stem cells (ESCs), which are derived from the inner cell mass (ICM) of the blastocyst, are representative of PSCs. However, use of these cells has ...
Park Man Jae - - 2012
Excess electron transfer dynamics in DNA hairpins was investigated by femtosecond laser flash photolysis of a donor-DNA-acceptor system using N,N-dimethylaminopyrene and diphenylacetylene as an electron donor and acceptor, respectively. It was revealed that the excess electron hopping rate between T's is faster than that of the hole.
Xiao Haibo - - 2012
A series of novel 9,9'-spirobifluorene-bridged donor-π-acceptor chromophores containing triarylamine moieties were easily synthesized starting from the readily available reagent 4,4'-dimethylbiphenyl. These chromophores were found to combine excellent transparency in the visible region, high thermal stabilities, and large optical nonlinearity.
Ertaş Gökhan - - 2012
Abstract Introduction: Red cell distribution width (RDW) has been associated with poor outcomes in patients with cardiovascular diseases. However, little is known about the role of RDW in prediction of new-onset atrial fibrillation (AF) after coronary artery bypass grafting (CABG). We aimed to investigate the relation between the RDW and ...
Hong Bor-Cherng - - 2012
A new method has been developed for the enantioselective synthesis of highly functionalized hydropentalenes bearing up to four stereogenic centers with high stereoselectivity (up to 99% ee). This process combines an enantioselective organocatalytic anti-selective Michael addition with a highly efficient one-pot reduction/lactonization/Pauson-Khand reaction sequence. The structures and absolute configurations of ...
Tan Min - - 2012
Leucyl-tRNA synthetase from Escherichia coli (EcLeuRS) has evolved both tRNA-dependent pre- and post-transfer editing capabilities to ensure catalytic specificity. Both editing functions rely on entry of the tRNA CCA tail into the editing domain of the LeuRS enzyme, which, according to X-ray crystal structural studies, leads to a dynamic, disordered ...
Demergis Vassili - - 2012
We demonstrate nanometer precision manipulation of multiple nanoparticles at room temperature. This is achieved using the optical binding force, which has been assumed to be weak compared to the optical gradient and scattering forces. We show that trapping by the optical binding force can be over 20 times stronger than ...
Catalano Jeffrey G - - 2012
Introduction of coal fly ash into aquatic systems poses a potential environmental hazard because of its heavy metal content. Here we investigate the relationship between solid phase transformations, fluid composition, and metal release and speciation during prolonged wet aging of a class C and class F coal fly ash. The ...
Baligand Celine - - 2012
BACKGROUND: In vivo gene electrotransfer is frequently used in preclinical gene therapy. Many studies have attempted to optimize protocols efficiency while reducing muscle damage. Most of them reported histological evidence of muscle degeneration and completion of regeneration within 15 days. The functional consequences have rarely been addressed, which may reflect the ...
Fagerland Morten W - - 2012
We examine goodness-of-fit tests for the proportional odds logistic regression model-the most commonly used regression model for an ordinal response variable. We derive a test statistic based on the Hosmer-Lemeshow test for binary logistic regression. Using a simulation study, we investigate the distribution and power properties of this test and ...
Saleh Amr A E - - 2012
Optical trapping using focused laser beams has emerged as a powerful tool in the biological and physical sciences. However, scaling this technique to nano-sized objects remains challenging due to the diffraction limit of light and the high power levels required for nanoscale trapping. In this paper, we propose plasmonic coaxial ...
Bhattacharyya Koyel X - - 2012
This paper describes a new series of organometallic water-soluble chelators combining a redox moiety (ferrocene) and a selective Ca(2+) chelator (BAPTA) separated by an ethynyl bridge. We report the synthesis and characterization of organometallic derivatives of the BAPTA chelator featuring one () and two ferrocenyl () moieties. Single crystal X-ray ...
Rashamuse Konanani - - 2012
A shotgun metagenomic library was constructed from termite hindgut symbionts and subsequently screened for esterase activities. A total of 68 recombinant clones conferring esterolytic phenotypes were identified, of which the 14 most active were subcloned and sequenced. The nucleotide lengths of the esterase-encoding open reading frames (ORFs) ranged from 783 ...
Panahi Yunes - - 2012
BACKGROUND: Chronic cutaneous complications such as pruritus are among the very frequent complaints of sulphur mustard (SM)-exposed patients. The present trial investigated the impact of curcumin on serum inflammatory biomarkers and their association with pruritus severity and quality of life (QoL). METHODS: This was a randomized, double-blind trial among 96 ...
Sah Shatrughan P - - 2012
AIMS: DOG1 is a recently described marker of gastrointestinal stromal tumour (GIST) which is considered to be extremely sensitive and, among mesenchymal neoplasms, quite specific for this tumour type. Following the identification of DOG1 immunoreactivity in a uterine leiomyosarcoma, we wished to ascertain how prevalent DOG1 immunoreactivity was in this ...
Gama Sofia - - 2012
New [PtCl(pz*NN)](n+) complexes anchored by pyrazolyl-diamine (pz*NN) ligands incorporating anthracenyl or acridine orange DNA-binding groups have been synthesized so as to obtain compounds that would display synergistic effects between platination and intercalation of DNA. Study of their interaction with supercoiled DNA indicated that the anthracenyl-containing complex L(2) Pt displays a ...
Schrezenmeier Eva - - 2012
Background/Aims: Putative in vitro-in vivo correlations of pharmacokinetic (PK) parameters are regarded as a prerequisite to filter hits derived from high-throughput screening (HTS) approaches for subsequent murine in vivo PK studies. Methods: In this study, we assessed stabilities in rat and human microsomes of 121 compounds from an early, academic ...
Klimek-Piotrowska Wiesława - - 2012
During a routine dissection at the Department of Anatomy, Collegium Medicum, Jagiellonian University, one cadaver was found to have multiple variations of the arteries of the upper limbs. The variations pertained to the course of the brachial artery as well as to its distribution. An unusual formation of the superficial ...
Himanen Risto - - 2012
There are four operating nuclear power plant (NPP) units in Finland. The Teollisuuden Voima (TVO) power company has two 840 MWe BWR units supplied by Asea-Atom at the Olkiluoto site. The Fortum corporation (formerly IVO) has two 500 MWe VVER 440/213 units at the Loviisa site. In addition, a 1600 ...
Martins Clarice - - 2012
Background: Metabolic Syndrome (MS) is highly prevalent among obese children with fatty liver. However, it is well-known that there is a lower prevalence of MS in individuals with higher cardiorespiratory fitness (CRF). Aim: To analyse the association between CRF with features of the MS in obese children that present fat ...
Gow Alan J - - 2012
OBJECTIVES: To examine the cognitively protective effect of leisure and physical activities while accounting for prior cognitive ability, a rarely considered confounder of the previously reported associations between activity and cognitive aging. DESIGN: Longitudinal cohort study. SETTING: Glostrup, Denmark. PARTICIPANTS: Community-dwelling sample of adults recruited into the Glostrup 1914 Cohort ...
Chae Jong Pyo - - 2012
AIMS: To clone, characterise, and compare the bile salt hydrolase (BSH) genes of Lactobacillus johnsonii PF01. METHODS AND RESULTS: The BSH genes were amplified by polymerase chain reaction (PCR) using specific oligonucleotide primers, and the products were inserted into the pET21b expression vector. Escherichia coli BLR (DE3) cells were transformed ...
Abreu-Blanco Maria Teresa - - 2012
The repair of injured tissue must occur rapidly to prevent microbial invasion and maintain tissue integrity. Epithelial tissues in particular, which serve as a barrier against the external environment, must repair efficiently in order to restore their primary function. Here we analyze the effect of different parameters on the epithelial ...
Armstrong Jennifer A - - 2012
Nine new cobalt fluorophosphates frameworks have been synthesised hydrothermally in a fluoride-rich medium, through the use of CoF(3) and HPF(6) as reactants in combination with Group I/II metal hydroxides and organic cations as templating species. Products have been structurally characterised using single crystal X-ray diffraction. Reaction in fluoride-rich conditions produces ...
Clark David W - - 2012
BACKGROUND: The pathogenesis of allergic fungal rhinosinusitis (AFRS) is thought to represent an immunological reaction to fungal antigens. Recent studies have implicated superantigens and non-immunoglobulin E (IgE)-mediated mechanisms in the development of AFRS. The objective of this study is to assess the prevalence of Staphylococcus aureus in AFRS vs other ...
He Zhi - - 2012
Excellent tolerance: Stable acylboronates equipped with N-methyliminodiacetyl (MIDA) boryl groups ([B]) were prepared by using a sequence of oxidative manipulations at the boron-bound carbon center (green in scheme). Chemoselective transformations of these acylated organoboron building blocks yielded a range of multifunctionalized boron derivatives and supplied access to valuable borylated heterocycles.
Abhishek Abhishek - - 2012
ABSTRACT: INTRODUCTION: We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine if metacarpophalangeal joints (MCPJ) calcification and CC at other joints occurs in the absence of knee involvement. METHODS: This was a cross sectional study embedded in the Genetics of Osteoarthritis and Lifestyle study (GOAL). All ...
Osman Dani - - 2012
The Janus Kinase (JAK) Signal Transducer and Activator of Transcription (STAT) pathway is involved in the regulation of Intestinal Stem Cell (ISC) activity to ensure a continuous renewal of the adult Drosophila midgut. Three ligands, Unpaired1, 2 and 3 are known to activate the JAK/STAT pathway in Drosophila. Using newly ...
Casal Charliana - - 2012
OBJECTIVES: To investigate the risk factors for infection and the outcome of pregnancy in women diagnosed with syphilis using a molecular approach. METHODS: Case-control study of pregnant women admitted to a maternity ward, with the cases classified as early or latent maternal syphilis, based on clinical-serological diagnoses. The DNA of ...
Shabsigh Ridwan - - 2012
Introduction.  Tadalafil is efficacious and well tolerated for erectile dysfunction (ED), but effects in men with "complete ED" are unclear. Aim.  To investigate effects of once-daily tadalafil in men with no successful intercourse attempts at baseline. Methods.  Through a post hoc, pooled-data analysis of four randomized, double-blind trials on the ...
Farnaby Joy H - - 2012
The reaction chemistry of the side-on bound (N(2))(2-), (N(2))(3-), and (NO)(2-) complexes of the [(R(2)N)(2)Y](+) cation (R = SiMe(3)), namely, [(R(2)N)(2)(THF)Y](2)(μ-η(2):η(2)-N(2)), 1, [(R(2)N)(2)(THF)Y](2)(μ-η(2):η(2)-N(2))K, 2, and [(R(2)N)(2)(THF)Y](2)(μ-η(2):η(2)-NO), 3, with oxidizing agents has been explored to search for other (E(2))(n-), (E = N, O), species that can be stabilized by this cation. ...
Anderson Eloy Jean - - 2012
BACKGROUND: Successful reconstruction of large anterior skull base (ASB) defects after craniofacial resection of malignant skull base tumors is paramount for preventing cerebrospinal fluid (CSF) fistulas. The vascularized pedicled pericranial flap (PCF) has been the gold standard for repairing ASB defects after transbasal transcranial approaches. However, flap necrosis and delayed ...
Tavares L - - 2012
Here, we report localized, polarized and waveguided electroluminescence (EL) from well aligned organic nanofibres integrated via roll printing on transistor platforms. The localized emission is due to the application of an alternating current voltage to the transistor gate electrodes, which causes sequential injection of holes and electrons into the organic ...
Barker David J P - - 2012
Context: Memorial to Jim Tanner. Objective: To examine the links between early growth and chronic disease in later life. Methods: Literature review. Results: There is now a developmental model for the origins of chronic disease in which the causes to be identified are linked to normal variations in feto-placental, infant ...
Marras Theodore K - - 2012
SUMMARY AT A GLANCE: We evaluated CT features, symptoms and microbiological disease criteria in pulmonary Mycobacterium xenopi. Cavitation and large nodules were associated with microbiologic criteria for disease. Bronchiectasis and small nodules were associated with symptoms. Cavitation and large nodules should be considered as being supportive for early initiation of ...
< 5 6 7 8 9 10 11 12 13 14 15 >