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Seifert Susan - - 2012
The adsorption of poly(vinylformamide) (PVFA) and its derivated statistic copolymers poly(vinyl-formamide-co-vinylamine) (PVFA-co-PVAm) on metallic copper and copper oxide particles as well as planar copper surfaces was investigated as function of the degree of hydrolysis, pH and polymer concentration in solution. The chemical composition and structure of the PVFA-co-PVAm layers were ...
Kale Seyit - - 2012
Easy come, easy go: LEWIS, a new model of reactive and polarizable water that enables the simulation of a statistically reliable number of proton hopping events in aqueous acid and base at concentrations of practical interest, is used to evaluate proton transfer intermediates in aqueous acid and base (picture, left ...
Kondo Masateru - - 2012
Background: The functional role of the cavotricuspid isthmus (CTI) for common atrial flutter (cAFL) remains to be elucidated. In the present study, we examined whether the EnSite system (St. Jude Medical, St. Paul, MN, USA), a noncontact mapping system, is useful to evaluate the conduction properties of CTI to minimize ...
Wang Yiguan - - 2012
ABSTRACT Parkinson's disease (PD) is a common neurodegenerative disease, the risk factors of which are gaining more attentions. Among all these risk factors, catechol-o-methyltransferase (COMT) has been widely studied, and believed to be associated with PD. However, the relationship between COMT polymorphism and PD has not been confirmed hitherto. Therefore, ...
Ostadal Petr - - 2012
ABSTRACT: INTRODUCTION: Prognostic stratification of cardiac arrest survivors (CAS) is essential for the selection of the most appropriate therapeutic strategy. However, accurate early outcome predictions for this patient population remain challenging. At present, there is a lack of data examining the prognostic value of C-terminal provasopressin (copeptin) in CAS. METHODS: ...
Alain Karine - - 2012
Aromatic hydrocarbons are among the main constituents of crude oil and represent a major fraction of biogenic hydrocarbons. Anthropogenic influences as well as biological production leads to exposure and accumulation of these toxic chemicals in the water column and sediment of marine environments. The ability to degrade these compounds in ...
Jamieson Frances F - - 2012
This study examined the antigenic and genetic diversity of serogroup B Neisseria meningitidis (MenB) recovered from invasive meningococcal disease (IMD) cases in Ontario, Canada for the 10 year period of 2001 to 2010 during which no MenB outbreaks had occurred. MenB was found to be responsible for 39% of all ...
Bradford Andrea - - 2012
Introduction.  Placebo responses are substantial in many clinical trials of treatments for female sexual dysfunctions (FSDs). Recent studies from other fields suggest a need to reconceptualize placebo response and to design future trials accordingly. Aim.  The aims of this review are to (i) summarize current conceptualizations of placebo response in ...
Paier S - - 2012
For the first time we present the case of a microsurgical reconstruction with an osteo-tendo-cutaneous free flap harvested from the medial femoral condyle for the coverage of a bone-tendon-soft tissue defect of the foot.�
Di Antonio Marco M University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, - - 2012
It all clicks into place: A potent telomere-targeting small molecule has been identified by using the copper-free 1,3-dipolar cycloaddition of a series of alkyne and azide building blocks catalyzed by a non-Watson-Crick DNA secondary structure (see picture). This method rapidly identifies, otherwise unanticipated, potent small-molecule probes to selectively target a ...
Li Philip Hei - - 2012
Objective. This study aims to identify the existence of, and relationship between autoantibody clusters and clinical subsets in Chinese SLE patients.Methods. Data from 1928 SLE patients from Hong Kong were analysed. Using cluster analysis, patients were grouped by autoantibodies into clusters. The frequencies of various clinical manifestations were then compared ...
Wang Xi - - 2012
Abstract miR-34a was identified as one of the downregulated microRNAs (miRNAs) in human lung cancer. However, the precise biological role of miR-34a in p53 deficient lung cancer cell lines remains largely elusive. In the present study, we aimed to identify the role of miR-34a in the regulation of lung cancer ...
Martí-Gastaldo Carlos - - 2012
Pepped up: Notwithstanding the intrinsic conformational flexibility of peptides, [Zn(Gly-Thr)(2) ] behaves as a robust porous metal-organic framework thanks to the rigidity introduced by the use of Gly-Thr. This rigidity arise from the sequence of amino acids in the dipeptide that locks its conformational flexibility in the framework.
Stranne Johan - - 2012
Abstract Objective.The aim was to explore how erectile dysfunction (ED) correlates with increasing age and a number of demographic, physical and lifestyle factors. Material and methods. A questionnaire was sent to a random sample (10 458) of men living in Gothenburg, Sweden, in 1992. The men were from the age ...
Sgro Michael J - - 2012
Frustrating ruthenium: The ruthenium complex 1 is shown to bind carbon dioxide or aldehyde in a manner similar to a frustrated Lewis pair. Compound 2 catalyzes the reduction of CO(2) in the presence of pinacolborane (HBpin), yielding MeOBpin and O(Bpin)(2) (see picture; Ru red, P orange, N green, O light ...
Bei Ling L Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, - - 2012
HoxA10 is a homeodomain transcription factor that is involved in maintenance of the myeloid progenitor population and implicated in myeloid leukemogenesis. Previously, we found that FGF2 and CDX4 are direct target genes of HoxA10 and that HOXA10 is a Cdx4 target gene. We also found that increased production of fibroblast ...
Kumamoto Hiroki - - 2012
4-exo-trig Cyclization reaction of a 4-pentenyl carbon radical containing the gem-difluoromethylene moiety adjacent to a radical accepting α,β-unsaturated ester was found to proceed efficiently to furnish a novel gem-difluorocyclobutane derivative. The cyclized product could be transformed into a gem-difluoromethylene analogue of oxetanocin T.
Kandane-Rathnayake Rangi K - - 2012
INTRODUCTION: The Australian and New Zealand Haemostasis Registry (ANZHR) included patients who received off-licence recombinant activated factor VII (rFVIIa) for critical bleeding from 2000 to 2009. Approximately 1.3% of the ANZHR patients were Jehovah's Witnesses (JWs). We compared them with the non-JW patients in the registry. METHODS: Patient characteristics (e.g. ...
Zhang Hailong H Division of Hematology/Oncology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, - - 2013
Inactivation of the tumor suppressor Ras-association domain family 1 isoform A (RASSF1A) due to epigenetic silencing occurs in a variety of human cancers, and still largely unknown are the regulators and mechanisms underlying RASSF1A gene promoter methylation. Herein, we report that this methylation is regulated by p53 and death-associated protein ...
Ruiz José - - 2012
Four new dinuclear complexes [Ni(μ-L)(μ-OAc)Ni(H(2)O)(2)]NO(3) (), Ni(μ-L)(μ-OBz)Ni(H(2)O)(MeOH)]NO(3)·3MeOH (), [Ni(μ-L)(μ-9-An)Ni(H(2)O)(MeOH)]NO(3) () and [Ni(μ-L)(μ-OAc)Ni(H(2)O)(N(3))]·CH(3)OH () have been prepared from the compartmental ligand N,N',N''-trimethyl-N,N''-bis(2-hydroxy-3-methoxy-5-methylbenzyl)diethylenetriamine (H(2)L) and different carboxylate ligands (OBz = benzoate and 9-An = 9-anthracenecarboxylate), and then magnetically and structurally characterized. The X-ray structures of these complexes reveal that the Ni(2+) ions ...
Zhou Xiaoyuan - - 2012
Since 2003, China has experimented in some of the country's counties with the private administration of the New Cooperative Medical Scheme (NCMS), a publicly subsidized health insurance scheme for rural populations. Our study compared the effectiveness and efficiency of private vs public administration in four counties in one of China's ...
Derrah Eric J - - 2012
Gold, silver and rhodium complexes of the diphosphine-phosphine oxide DPPO = {[o-iPr(2)P-(C(6)H(4))](2)P(O)Ph} have been prepared and characterized. Thanks to its polyfunctional character, DPPO features versatile coordination properties. According to crystallographic data, only one phosphine moiety is engaged in coordination towards (AuCl) and [RhCl(nbd)]. However, NMR data indicate fluxional behavior in ...
Zhu San-E - - 2012
Thermal reactions of [60]fullerene with a series of amino acids and amino acid esters under aerobic and dark conditions have been investigated. Fulleropyrrolidines can be obtained from these reactions although an aldehyde is not added purposely. Possible reaction mechanisms involving uncommon C-N bond cleavages have been proposed to generate aldehydes, ...
Unnadkat Nausheel R - - 2012
Polyphenols are attractive ingredients due to their purported health benefits, but their addition to foods is limited by their chemical instability, as they are rapidly oxidized under many conditions. This oxidation not only compromises the potential biological activity of the phenolic compound, but can also affect the chemical stability of ...
Hill Kristina E KE Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, - - 2012
Sepp1 transports selenium, but its complete role in selenium homeostasis is not known. Deletion of Sepp1 in hepatocytes increases liver selenium at the expense of other tissues and decreases whole-body selenium by increasing excretion. Sepp1 production by hepatocytes retains selenium in the organism and distributes it from the liver to ...
Hassan C - - 2012
BACKGROUND: A variety of tests have been proposed for colorectal cancer (CRC), giving rise to uncertainty regarding the optimal approach. The efficacy and effectiveness of different tests are related to both screenee participation and the detection rate. AIM: To perform a meta-analysis on adherence and detection rates of CRC screening ...
Choi Yoon Jeong YJ Division of Digestive Diseases, David Geffen School of Medicine, University of California–Los Angeles, Los Angeles, California 90095, - - 2013
Defective IL-10 allele is a risk factor for intestinal inflammation. Indeed, IL-10(-/-) mice are predisposed to spontaneous colitis in the presence of intestinal microbiota, indicating that microbial factors contribute to developing intestinal inflammation. By recognizing flagellin, TLR5 plays a quintessential role in microbial recognition in intestinal epithelial cells. Here, we ...
Haenen Steven - - 2012
Some reactive chemicals, such as diisocyanates, are capable of initiating an allergic response, which can lead to occupational asthma after a latency period. Clinical symptoms such as cough, wheezing and dyspnea occur only late, making it difficult to intervene at an early stage. So far, most studies using proteomics in ...
Rentsch Daniel - - 2012
The quality of preloaded Wang resins is very important for the success of solid phase peptide syntheses (SPPS). A critical factor is the capping of remaining hydroxyl groups after loading with the first amino acid, since these free alcohols lead to truncated sequences during the following SPPS steps. As the ...
Wang Haifang - - 2012
A diverse array of carbon nanomaterials (NMs), including fullerene, carbon nanotubes (CNTs), graphene, nanodiamonds, and carbon nanoparticles, have been discovered and widely applied in a variety of industries. Carbon NMs have been detected in the environment and have a strong possibility of entering the human body. The safety of carbon ...
Wehbe Edgard E Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. - - 2013
Patients with AKI after lung transplantation are at increased risk for CKD and death. Whether patients who completely recover from AKI have improved long-term outcome compared with patients who do not completely recover remains unknown. This study retrospectively evaluated data on 657 patients who underwent lung transplantation from 1997 to ...
Rybakowski J K - - 2012
We present the case of a male patient with a family history of both bipolar disorder (BD) and Wilson's disease (WD). Wilson's disease was diagnosed for this patient in 2008, at the age of 28 years, and shortly thereafter his bipolar illness began with depressive episodes. The patient has been ...
Morgan Kevin - - 2012
OBJECTIVES: To evaluate the effectiveness of a self-help cognitive behavioral intervention in improving sleep quality in older adults reporting insomnia symptoms associated with chronic disease. DESIGN: A pragmatic two-arm randomized controlled trial comparing supported self-help with treatment as usual (TAU). SETTING: Primary care. PARTICIPANTS: One hundred ninety-three self-referred individuals aged ...
Hillman Noah H NH Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Ohio, USA. - - 2012
Preterm infants often receive mechanical ventilation and oxygen at birth. Exposure to large tidal volumes (V(T)s) at birth causes lung inflammation, and oxygen may amplify the injury. We hypothesized that normal V(T) ventilation at birth causes lung injury that is exacerbated by 95% oxygen. The head and chest of anesthetized ...
Changeux Jean-Pierre JP Collège de France, 75005 Paris, France. - - 2012
A critical event in the history of biological chemistry was the chemical identification of the first neurotransmitter receptor, the nicotinic acetylcholine receptor. Disciplines as diverse as electrophysiology, pharmacology, and biochemistry joined together in a unified and rational manner with the common goal of successfully identifying the molecular device that converts ...
Hollands Andrew A Department of Pediatrics, University of California, San Diego, La Jolla, California 92093, - - 2012
The bacterial pathogen Group A Streptococcus (GAS) colonizes epithelial and mucosal surfaces and can cause a broad spectrum of human disease. Through the secreted plasminogen activator streptokinase (Ska), GAS activates human plasminogen into plasmin and binds it to the bacterial surface. The resulting surface plasmin protease activity has been proposed ...
Zhang Fan - - 2012
The PALB2 protein is associated with breast cancer susceptibility and Fanconi anemia. Notably, PALB2 is also required for DNA repair by homologous recombination (HR). The mechanisms that regulate PALB2, and the functional significance of its interaction with the BRCA1 breast cancer susceptibility protein, are poorly understood, however. Here, to better ...
Janus N - - 2012
BackgroundOne million people worldwide benefit from chronic dialysis, with an increased rate in Western countries of 5% yearly. Owing to increased incidence of cancer in dialyzed patients, the management of these patients is challenging for oncologists/nephrologists.Patients and methodsThe CANcer and DialYsis (CANDY) retrospective multicenter study included patients under chronic dialysis ...
Visco Anthony G AG Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27707, USA. - - 2012
Anticholinergic medications and onabotulinumtoxinA are used to treat urgency urinary incontinence, but data directly comparing the two types of therapy are needed. We performed a double-blind, double-placebo-controlled, randomized trial involving women with idiopathic urgency urinary incontinence who had five or more episodes of urgency urinary incontinence per 3-day period, as ...
Partovi Sasan - - 2012
ABSTRACT: INTRODUCTION: Muscle symptoms in systemic sclerosis (SSc) may originate from altered skeletal muscle microcirculation, which can be investigated by means of blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI). METHODS: After ethics committee approval and written consent, 11 consecutive SSc patients (5 men, mean age 52.6 years, mean ...
Michael Amanda - - 2012
Abstract Laparoscopic radical nephrectomy is commonly used to treat renal masses. Given the ubiquitous presence of this technique, rare complications are becoming more commonplace. It is thus essential that practicing urologists be aware of all possible complications as well as the novel management approaches that exist. This report presents a ...
Haranczyk Maciej - - 2012
Congeners are molecules based on the same carbon skeleton but different by the number of substituents and/or a substitution pattern. Examples are 1-chloronaphthalene, 1,4-dichloronaphthalene and 1,3,8-trichloronaphthalene. Various Persistent Organic Pollutants (POPs) exist in the environment as families of congeners. Very large numbers of possible congeners make their experimental characterization and ...
Yoshioka Seisuke S Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, - - 2013
Tertiary dentin is deposited inside teeth after various stimuli and serves as a major defensive wall to preserve pulp cells. However, the molecular mechanisms of the activation of quiescent odontoblasts, immature pulp cells and tertiary dentin formation are still unclear. Therefore, we performed a comprehensive gene expression analysis of pulp ...
Betzelberger Amy M - - 2012
Current background ozone (O(3)) concentrations over the northern hemisphere's midlatitudes are high enough to damage crops and are projected to increase. Soybean (Glycine max) is particularly sensitive to O(3); therefore, establishing an O(3) exposure threshold for damage is critical to understanding the current and future impact of this pollutant. This ...
Filippi Andrea Riccardo - - 2012
Abstract Aim of the study was investigating whether iPET is prognostic in a cohort of early stage patients homogeneously treated with 3-4 ABVD cycles followed by 30 Gy Involved Field Radiotherapy. Eighty patients were selected (stage I-IIA HL, availability of iPET, minimum follow-up of 12 months), and after central review, ...
Walsh Alex J - - 2012
BACKGROUND AND OBJECTIVES: With the increasing use of fluorescence in medical applications, a comprehensive understanding of the effect of temperature on tissue autofluorescence is essential. The purpose of this study is to explore the effect of temperature on the fluorescence of porcine cornea and rat skin and determine the relative ...
Stafforst Thorsten - - 2012
Checking for mistakes: By conjugating a catalytic domain with a guide RNA, deamination activity can be harnessed to repair a specific codon on mRNA. This method can be used for the highly selective repair of point mutations in mRNA by site-selective editing.
Goltz Heather Honoré - - 2012
Introduction.  A growing literature suggests relationships between erectile dysfunction medications (EDM) and riskier sexual behavior among men who have sex with men (MSM). Questions remain concerning EDM use and related HIV/sexually transmitted infections (STI) risk among older MSM, particularly those 40 years and over, for whom EDM may be medically ...
Zhang Wangbing - - 2012
A novel non-chromatographic speciation technique for ultratrace inorganic mercury (Hg2+) and methylmercury (CH3Hg+) in biological materials is developed and validated by electrolytic vapor generation (EVG) coupled with atomic fluorescence spectrometry (AFS). The studies show that CH3Hg+ and Hg2+ can be conversed to Hg vapor efficiently on an L-cysteine modified graphite ...
Agina Elena V - - 2012
Different techniques for a relatively fast self-assembled monolayer film formation such as Langmuir-Blodgett (LB), spin-coating and dip-coating methods have been compared using chloro[11-(5''''-ethyl-2,2':5',2'':5'',2''':5''',2''''-quinquethiophene-5-yl)undecyl]dimethylsilane as a reactive precursor. It was shown that both spin-coating and LB techniques are very promising methods for preparation of highly ordered monolayer films of organosilicon-functionalized quinquethiophene ...
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