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Results 401 - 450 of 1352
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de Jager C P C - - 2012
BACKGROUND: The pathophysiological mechanisms which contribute to an increased risk of community-acquired pneumonia (CAP) in patients using proton pump inhibitors are not well established. AIM: To examine differences in microbial etiology in patients with CAP between patients with and without proton pump inhibitor (PPI) therapy and its possible impact on ...
Tewari Alok K - - 2012
ABSTRACT: BACKGROUND: Epigenetic mechanisms such as chromatin accessibility impact transcription factor binding to DNA and transcriptional specificity. The androgen receptor (AR), a master regulator of the male phenotype and prostate cancer pathogenesis, acts primarily through ligand-activated transcription of target genes. Although several determinants of AR transcriptional specificity have been elucidated, ...
Floriddia Elisa M - - 2012
Following spinal trauma, the limited physiological axonal sprouting that contributes to partial recovery of function is dependent upon the intrinsic properties of neurons as well as the inhibitory glial environment. The transcription factor p53 is involved in DNA repair, cell cycle, cell survival, and axonal outgrowth, suggesting p53 as key ...
Monnereau Alain - - 2012
Long-term population-based survival data detailed by cancer subtype are important to measure the overall outcomes of malignancy managements. We provide net survival estimates at 1, 3, 5, and 10 years post-diagnosis on 37,549 haematological malignancy (HM) patients over 15 years old diagnosed between 1989 and 2004 and actively followed until ...
McNeill Ann - - 2012
If current trends in smoking prevalence continue, even with the implementation of enhanced tobacco control measures, millions of smokers will continue to fall ill and die as a direct result of their smoking. Many of these will be from the most deprived groups in society - smoking continues to be ...
Spiller Cassy M - - 2012
Germ cells, the embryonic precursors of sperm or oocytes, respond to molecular cues that regulate their sex-specific development in the fetal gonads. In males in particular, the balance between continued proliferation and cell fate commitment is crucial: defects in proliferation result in insufficient spermatogonial stem cells for fertility, but escape ...
Fink Jakob - - 2012
Basilar artery occlusion in children is rare. It has a high mortality and morbidity if recanalization is not achieved before extensive brainstem infarction has occurred. An 11-year-old boy presented with a clinical and radiological "top-of-the-basilar" syndrome. Intravenous tissue plasminogen activator was administered, and the patient was immediately referred to the ...
Yazicioglu Alkin - - 2012
Chyloptysis and chylomediastinum are uncommon complications of various kinds of thoracic operations, malign and nonmalign diseases. In the English language medical literature, there were no cases of both chylomediastinum and chyloptysis following trauma. We discuss a case of chylomediastinum and chyloptysis after penetrating trauma. The patient sustained a bullet wound ...
Dodds Pennie - - 2012
Miller (1956) identified his famous limit of 7 ± 2 items based in part on absolute identification-the ability to identify stimuli that differ on a single physical dimension, such as lines of different length. An important aspect of this limit is its independence from perceptual effects and its application across all stimulus ...
Voormolen Eduard H - - 2012
During endoscopic trans-sphenoidal treatment of petrous apex cholesterol granuloma, the challenge for the surgeon is to drill the posterior wall of the sphenoid sinus to reach the lesion while attempting to avoid the internal carotid artery (ICA). A refined neuronavigation technique is presented that diminishes bonework needed for exposure and ...
Ghassemi Fariba - - 2012
PURPOSE: The aim of this study was evaluation of the regression patterns after 3, 6, and 8 months of treatment. METHODS: A total of 100 retinoblastoma tumors (57 eyes of 35 patients) were treated with 6 (n = 8) or 8 (n = 92) cycles of systemic chemoreduction and tumor consolidation (transpupillary thermotherapy [TTT] ...
Gross Claus Michael - - 2012
Fingolimod, a sphingosine 1-phosphate receptor modulator, is highly effective in the treatment of multiple sclerosis (MS).(1,2) However, fatal cases of herpes infection have occurred in 2 patients on fingolimod therapy, 1 of whom presented with a primary disseminated varicella-zoster virus (VZV) infection (no history of chicken pox, negative baseline serology).(2) ...
Young Scott J - - 2012
Studies suggest that dystonia is associated with increased motor cortex excitability. Cathodal transcranial direct current stimulation can temporarily reduce motor cortex excitability. To test whether stimulation of the motor cortex can reduce dystonic symptoms in children, we measured tracking performance and muscle overflow using an electromyogram tracking task before and ...
Pakdeechanuan Phattharaporn - - 2012
Nornicotine is formed from nicotine by nicotine N-demethylase, a CYP82E family monooxygenase, and accumulates to high levels in some tobacco (Nicotiana tabacum) cultivars and many wild Nicotiana species. N. langsdorffii does not form nornicotine, whereas the closely related species N. alata accumulates this alkaloid abundantly. We show here that the ...
de Ligt Joep - - 2012
The causes of intellectual disability remain largely unknown because of extensive clinical and genetic heterogeneity. We evaluated patients with intellectual disability to exclude known causes of the disorder. We then sequenced the coding regions of more than 21,000 genes obtained from 100 patients with an IQ below 50 and their ...
Ganusov Vitaly V - - 2012
Bromodeoxyuridine (BrdU) is widely used in immunology to detect cell division, and several mathematical models have been proposed to estimate proliferation and death rates of lymphocytes from BrdU labelling and de-labelling curves. One problem in interpreting BrdU data is explaining the de-labelling curves. Because shortly after label withdrawal, BrdU(+) cells ...
Apfel C C - - 2012
BACKGROUND: /st>In assessing a patient's risk for postoperative nausea and vomiting (PONV), it is important to know which risk factors are independent predictors, and which factors are not relevant for predicting PONV. METHODS: /st>We conducted a systematic review of prospective studies (n>500 patients) that applied multivariate logistic regression analyses to ...
Liu Fei - - 2012
p21 (Cip1/CDKN1A) and p27 (Kip1/CDKN1B) are members of the Cip/Kip family of cyclin-dependent kinase inhibitors, which can arrest cell proliferation and serve as tumor suppressors. We hypothesized that genetic variants in p21 and p27 may modify individual susceptibility to hepatocellular carcinoma (HCC). To test this hypothesis, we evaluated the associations ...
Wiet Richard J - - 2012
ObjectiveTo compare short- and long-term hearing results following stapedectomy using 3 different oval window grafting materials with the same stapes prosthesis.Study DesignDatabase review.SettingTertiary referral private practice.Subjects and MethodsSubjects were ears that underwent stapedectomy for otosclerosis, with placement of fat, fascia, or vein as an oval window seal and reconstruction with ...
Lee Seung Woo - - 2012
Transition metal oxide and phosphate materials, commonly used for lithium battery devices, are active as oxygen evolution reaction (OER) catalysts under alkaline and neutral solution conditions. Electrodes comprised of LiCoO(2) and LiCoPO(4) exhibit progressive deactivation and activation for OER catalysis, respectively, upon potential cycling at neutral pH. Deactivation of LiCoO(2) ...
Mei May Lei - - 2012
OBJECTIVE: To determine the short-term stability of free fluoride ion concentrations and acidity (pH values) of three commercially available SDF solutions over time. METHODS: Three SDF products for caries control were studied: Cariestop-12%, Cariestop-30% and Saforide-38%. Their expected fluoride ion concentrations were 14,200, 35,400 and 44,800 ppm, respectively. The fluoride ion ...
Arnason Barry G - - 2012
The therapeutic benefits of adrenocorticotropic hormone in multiple sclerosis are usually ascribed to its corticotropic actions. Evidence is presented that adrenocorticotropic hormone, approved for multiple sclerosis relapses, acts via corticosteroid-independent melanocortin pathways to engender down-modulating actions on immune-system cells and the cytokines they synthesize. Immune response-dampening effects are also brought ...
Hung Yu-Shin - - 2012
This study aimed to compare multiaspect characteristics in cancer and noncancer patients who received palliative care. Totally, 226 patients with cancer and 115 noncancer patients received palliative care consultation service in Taiwan from September 2007 through December 2009 were retrospectively analyzed. Noncancer patients were older (81 vs 67 years, P ...
Mavrogeni S - - 2012
Objective: The objective of this paper is to evaluate the diagnostic role of cardiac magnetic resonance imaging (CMR) in detecting myocardial inflammation in systemic lupus erythematosus (SLE) and its differentiation from viral myocarditis.Patients and methods: Fifty patients with suspected infective myocarditis (IM), with chest pain, dyspnoea or altered ECG, increase ...
Adriaenssens Bart - - 2012
Individuals often show consistent behavioural differences where behaviours can form integrated units across functionally different contexts. However, the factors causing and maintaining behavioural syndromes in natural populations remain poorly understood. In this study, we provide evidence for the emergence of a behavioural syndrome during the first months of life in ...
Lu Chenguang - - 2012
The kinetics and intricate interactions governing the growth of 3D single NP superlattices (SLs, SNSLs) and binary NP SLs (BNSLs) in solution are understood by combining controlled solvent evaporation and in situ, real-time small angle X-ray scattering (SAXS). For the iron oxide (magnetite) NP SLs studied here, the larger the ...
Dubsky P - - 2012
BackgroundIn early estrogen receptor (ER)-positive/HER2-negative breast cancer, the decision to administer chemotherapy is largely based on prognostic criteria. The combined molecular/clinical EndoPredict test (EPclin) has been validated to accurately assess prognosis in this population. In this study, the clinical relevance of EPclin in relation to well-established clinical guidelines is assessed.Patients ...
Kavalali Ege T - - 2012
Recent clinical studies have demonstrated that a single subpsychotomimetic dose of ketamine, an ionotropic glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonist, produces a rapid antidepressant response in patients with major depressive disorder, with effects lasting up to 2 weeks. Despite enthusiasm about this unexpected efficacy of ketamine, its widespread use as a ...
Chan Kwan-Shan - - 2012
Objective:To investigate the effects of a single session of whole body vibration training on ankle plantarflexion spasticity and gait performance in chronic stroke patients.Design:Randomized controlled trial.Setting:Rehabilitation unit in university hospital.Participants:Thirty subjects with chronic stroke were randomized into either a control group (n = 15) or a group receiving a single ...
Li Zhu Juan - - 2012
Abnormal activation of Hedgehog (Hh) signaling leads to basal cell carcinoma (BCC) of the skin, the most common human cancer. Gli2, the major transcriptional activator of Hh signaling, is essential for hair follicle development and its overexpression in epidermis induces BCC formation and maintains tumor growth. Despite its importance in ...
Overgaard Hans J - - 2012
ABSTRACT: BACKGROUND: Diarrheal diseases and dengue fever are major global health problems. Where provision of clean water is inadequate, water storage is crucial. Fecal contamination of stored water is a common source of diarrheal illness, but stored water also provides breeding sites for dengue vector mosquitoes. Poor household water management ...
Gabreyes Alemayehu A - - 2012
Copper is an essential trace element that is involved in a number of important enzymatic processes throughout the body. Recent single case reports and small studies have shown that deficiency of copper can cause reversible haematological changes and irreversible neurological injury. We chose to undertake a national study, looking at ...
Chauhan Preeti - - 2012
Using a multimeasure longitudinal research design, we measured psychopathy with the Youth Psychopathic Traits Inventory (YPI) and the Psychopathy Checklist-Youth Version (PCL-YV) among 122 offending girls. We examined the psychometric properties of the YPI, investigated the association between the YPI and the PCL-YV, and assessed their concurrent and longitudinal association ...
Modur Vijay - - 2012
BACKGROUND:The promise of targeted therapies in molecularly defined subsets of cancer has led to a transformation of the process of drug development in oncology. To target cancer successfully and precisely requires high-quality translational data. Such data can be generated by the use of biomarkers that answer key questions in drug ...
Saritas Bulent - - 2012
Aneurysmal circumflex coronary artery fistula connected to the coronary sinus is a rare clinical entity that usually remains asymptomatic until later in life. The timing of surgical treatment for asymptomatic patients is crucial. The decision to leave or exclude the aneurysmatic coronary artery following ligation of the fistula is controversial. ...
Piana Mariana - - 2012
Heartsease, also known as wild pansy (Viola tricolor L.), contains considerable amounts of polyphenols: 109.32 ± 1.29 mg of Gallic acid equivalent/g of extract. This study investigates their phytoconstituents and antioxidant capacity and validates a method for the quantification of rutin in the crude extract of the flowers of V. ...
Bairey Osnat - - 2012
An Insect-bite-like reaction is known to occur in patients with chronic lymphocytic leukemia (CLL). Most of the literature, however, consists of isolated case reports or small case series. The aim of this retrospective study was to review the national experience with insect-bite-like reaction in a large group of patients with ...
Amarinthnukrowh Pramuk - - 2012
Wiskott-Aldrich syndrome (WAS) is an X-linked recessive primary immunodeficiency disorder caused by mutations in the gene encoding the WAS protein (WASP). Classic WAS is characterized by thrombocytopenia with small-sized platelets, recurrent infections, eczema, and increased susceptibility to autoimmune diseases and hematologic malignancies. Here, we reported on seven unrelated Thai individuals ...
McMahon N - - 2012
Blood pressure measurement is an essential physiological measurement for all critically ill patients. Previous work has shown that non-invasive blood pressure is not an accurate reflection of invasive blood pressure measurement. In a transport environment, the effects of motion and vibration may make non-invasive blood pressure less accurate. Consecutive critically ...
Aseeri Mohammed - - 2012
BackgroundChemotherapy-induced nausea and vomiting are the most dreaded and distressing side effects for cancer patients undergoing chemotherapy treatment. These side effects have a significant impact on the patients' quality of life and can interfere with their ability to receive intensive chemotherapy regimens. With the recent advances in antiemetic pharmacotherapy and ...
Rodrigo C - - 2012
Uncontrolled studies suggest that magnesium sulphate controls spasms in patients with established tetanus. We performed a meta-analysis of controlled trials that compared magnesium sulphate with placebo or diazepam for the treatment of patients with tetanus. We searched PubMed, Scopus, Embase and the Cochrane clinical trials registry. Three studies met the ...
Haider Syed - - 2012
ABSTRACT: BACKGROUND: The epigenomes of healthy and diseased human hearts were recently examined by genome-wide DNA methylation profiling. Repetitive elements, heavily methylated in post-natal tissue, have variable methylation profiles in cancer but methylation of repetitive elements in the heart has never been examined. RESULTS: We analyzed repetitive elements from all ...
Williams John P - - 2012
BACKGROUND: Cachexia is a consequence of tumor burden caused by ill-defined catabolic alterations in muscle protein turnover. OBJECTIVE: We aimed to explore the effect of tumor burden and resection on muscle protein turnover in patients with nonmetastatic colorectal cancer (CRC), which is a surgically curable tumor that induces cachexia. DESIGN: ...
Lu Puzhong - - 2012
PKZ (PKR-like) was discovered as a member of elF2α kinase family in fish, which possesses a conserved catalytic domain of an eIF2α kinase in C-terminal and also two Z-DNA-binding domains (Zα1 and Zα2) in N-terminal. PKZ can be activated through binding of Zα to Z-DNA. However, the regulatory function of ...
Santos S - - 2012
Two novel HLA-A29 alleles were described. A*29:39 differs from A*29:02:01 by three clustered amino acid replacements at α1 domain, T73>I73, A76>V76 and N77>D77. A*29:40 shows one nucleotide difference regarding A*29:02:01 allele, resulting in one amino acid substitution at position 154, E154>G154.
Bains P - - 2012
BackgroundThe established treatment of limited-stage follicular lymphoma is radiotherapy (RT). There is an inherent risk of transformation of follicular lymphoma to aggressive lymphoma; however, the frequency and impact on the outcome are unknown in limited-stage patients.Materials and methodsWe identified 237 patients with limited-stage follicular lymphoma treated with curative intent RT. ...
Brancolini Giorgia - - 2012
Protein-nanoparticle associations have important applications in nanoscience and nanotechnology such as targeted drug delivery and theranostic. However, the mechanisms by which proteins recognise nanoparticles and the determinants of specificity are still poorly understood at the microscopic level. Gold is a promising material in nanoparticles for nanobiotechnology applications because of the ...
Centonze Diego - - 2012
The risk of progressive multifocal leukoencephalopathy (PML) associated with prolonged natalizumab use in JCV-seropositive patients might motivate clinicians to switch patients with multiple sclerosis (MS) to fingolimod.(1,2) Many patients with MS taking natalizumab have failed first-line therapies such as interferon-β or glatiramer acetate, and are unlikely to respond to the ...
Wieberdink Renske G - - 2012
Insulin resistance, which plays a key role in the development of diabetes mellitus, is a putative modifiable risk factor for stroke. The aim of this study was to investigate if markers of insulin resistance were associated with risk of stroke in the general elderly population. This study was part of ...
Bénazet Jean-Denis - - 2012
SMAD4 is an essential mediator of canonical TGFβ/BMP signal transduction and we inactivated Smad4 in mouse limb buds from early stages onward to study its functions in the mesenchyme. While this Smad4 inactivation did not alter the early Sox9 distribution, prefiguring the chondrogenic primordia of the stylopod and zeugopod, it ...
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