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Park Juwan - - 2012
To examine the relative positions of the lacrimal fossa (LF) and the bony nasolacrimal canal (BNLC) in relation to each other and a reference plane. Forty-two orbits and BNLCs from 21 Asian cadavers (9 men and 12 women; average age at death, 84.4 years; range, 70-99 years) had been fixed ...
Tharin Suzanne - - 2012
While much is known about general controls over axon guidance of broad classes of projection neurons (those with long-distance axonal connections), molecular controls over specific axon targeting by distinct neuron subtypes are poorly understood. Corticospinal motor neurons (CSMN) are prototypical and clinically important cerebral cortex projection neurons; they are the ...
Glendenning-Napoli Alison - - 2012
PURPOSE OF THE STUDY:: To examine the effects of a community-based case management program on acute health care utilization and associated costs in uninsured patients with 1 or more chronic diseases. PRIMARY PRACTICE SETTING:: Large regional academic medical center that provides health care services for the vast majority of indigent ...
Richards Ayo-Lynn - - 2012
The aim of this article is to describe complications of hydrogel (MIRAgel) scleral buckle implants that may appear many years after implantation, and to describe an effective technique to facilitate safe removal of these implants, which become extremely friable with time. Four case reports of patients with complications of hydrogel ...
Powell Suzanne K - - 2012
When someone is very ill or has lost a loved one, this may be the hardest time to say the right words. Guidance is given on communication during these times.
Parker R David - - 2012
In 2010, more than 600,000 people in the United States experienced homelessness. Efficient and cost-effective housing methods that reduce homelessness need to be implemented. Housing Ready programs are the standard method that often has set requirements including earned income and sobriety, among others. These programs enable a subset of the ...
Kendall Bradley J BJ Cancer Program, Queensland Institute of Medical Research, Brisbane, QLD, Australia. - - 2013
Esophageal adenocarcinoma arises from Barrett's esophagus (BE). Both occur predominantly in males. The role of abdominal obesity in this sex distribution is uncertain. Our study aimed to determine whether there is an association between abdominal obesity and risk of BE and if present was it modified by sex. A structured ...
Olsson Niclas N Department of Immunotechnology, Lund University, Lund, - - 2012
Protein-peptide interactions are a common occurrence and essential for numerous cellular processes, and frequently explored in broad applications within biology, medicine, and proteomics. Therefore, understanding the molecular mechanism(s) of protein-peptide recognition, specificity, and binding interactions will be essential. In this study, we report the first detailed analysis of antibody-peptide interaction ...
Teh Muy-Teck MT Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, England, United Kingdom. - - 2013
Histopathological discordance with molecular phenotype of many human cancers poses clinically challenging tasks for accurate cancer diagnosis, which impacts on treatment strategy and patient outcome. Hence, an objective, accurate and quantitative method is needed. A quantitative Malignancy Index Diagnostic System (qMIDS) was developed based on 14 FOXM1 (isoform B)-associated genes ...
Jamshidi Maral M Department of Obstetrics and Gynecology, Biomedicum Helsinki, University of Helsinki and Helsinki University Central Hospital, 00029 Helsinki, - - 2013
Germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ was previously suggested to have an impact on drug response in vitro. Here, we investigated the effect on breast cancer survival of germline variation in these genes in 925 Finnish breast cancer patients and further analyzed five ...
de Groat W C - - 2013
The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain and spinal cord that coordinates the activity of the bladder and urethral outlet. Experimental studies in animals indicate that urine storage is modulated by reflex mechanisms ...
Xia Bijun B Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, 1838 N Guangzhou Avenue, Guangzhou, Guangdong 510515, - - 2012
Recycling in the gastrointestinal tract is important for endogenous substances such as bile acids and for xenobiotics such as flavonoids. Although both enterohepatic and enteric recycling mechanisms are well recognized, no one has discussed the third recycling mechanism for glucuronides: local recycling. The intestinal absorption and metabolism of wogonin and ...
Chan Yang-Hsiang YH Department of Chemistry, University of Washington, Seattle, Washington 98195, United - - 2012
Semiconducting polymer dots (Pdots) recently have emerged as a new class of ultrabright fluorescent probes with promising applications in biological detection and imaging. We developed photoswitchable Pdots by conjugating photochromic spiropyran molecules onto poly[9,9-dioctylfluorenyl-2,7-diyl)-co-1,4-benzo-{2,1'-3}-thiadiazole)] (PFBT). The modulation of fluorescence was achieved by ultraviolet irradiation, which converted spiropyran into its visible-absorbing ...
Simoni Elena - - 2012
Herein we report on a novel series of multitargeted compounds obtained by linking together galantamine and memantine. The compounds were designed by taking advantage of the crystal structures of acetylcholinesterase (AChE) in complex with galantamine derivatives. Sixteen novel derivatives were synthesized, using spacers of different lengths and chemical composition. The ...
Campbell Charles T - - 2012
Adsorbed molecules are involved in many reactions on solid surface that are of great technological importance. As such, there has been tremendous effort worldwide to learn how to predict reaction rates and equilibrium constants for reactions involving adsorbed molecules. Theoretical calculation of both the rate and equilibrium constants for such ...
Rasch Michael R - - 2012
Assemblies of saturated 1,2-diacylphosphatidylcholine lipid and hydrophobic dodecanethiol-capped 1.8 nm diameter gold nanocrystals were studied as a function of lipid chain length and the addition of the naturally occurring oil, squalene. The gold nanocrystals formed various lipid-stabilized agglomerates, sometimes fusing with lipid vesicle bilayers. The nanocrystal assembly structure depended on ...
Adachi Mariya S - - 2012
Flavoprotein Fms1 from Saccharomyces cerevisiae catalyzes the oxidation of spermine in the biosynthetic pathway for pantothenic acid. The same reaction is catalyzed by the mammalian polyamine and spermine oxidases. The active site of Fms1 contains three amino acid residues positioned to interact with the polyamine substrate, His67, Asn195, and Asp94. ...
Wang Zhen - - 2012
The role of protein flexibility in enzyme-catalyzed activation of chemical bonds is an evolving perspective in enzymology. Here we examine the role of protein motions in the hydride transfer reaction catalyzed by thymidylate synthase (TSase). Being remote from the chemical reaction site, the Y209W mutation of Escherichia coli TSase significantly ...
Ochodnicky P P Department of Pharmacology & Pharmacotherapy, Academic Medical Center, University of Amsterdam, Amsterdam, the - - 2013
The autonomic nervous system plays an important role in the regulation of the urinary bladder function. Under physiological circumstances, noradrenaline, acting mainly on β(3) -adrenoceptors in the detrusor and on α(1) (A) -adrenoceptors in the bladder outflow tract, promotes urine storage, whereas neuronally released acetylcholine acting mainly on M(3) receptors ...
Sedlacek Ondrej - - 2012
Poly(2-alkyl-2-oxazoline)s are biocompatible polymers with polypeptide-isomeric structures that are attracting increasing interest as biomaterials for drug, gene, protein, and radionuclide delivery. They are, however, still relatively new in comparison to other classes of hydrophilic water-soluble polymers already established for such use, including poly(ethylene oxide), polyvinylpyrrolidone, and polymethacrylamides such as poly[N-(2-hydroxypropyl)methacrylamide]. ...
Longenecker Jonilyn G JG Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United - - 2012
Detection of magnetic resonance as a force between a magnetic tip and nuclear spins has previously been shown to enable sub-10 nm resolution 1H imaging. Maximizing the spin force in such a magnetic resonance force microscopy (MRFM) experiment demands a high field gradient. In order to study a wide range ...
- - 2012
Although every state prohibits persons aged <21 years from driving with any measurable amount of blood alcohol, many young persons still drink and drive. Additionally, fatal crash data indicate that most teen drivers with positive (>0.00%) blood alcohol concentrations (BACs) who are involved in fatal crashes have BACs ≥0.08%, the ...
Prati Francesco - - 2012
Aims: Angiographic guidance for percutaneous coronary intervention (PCI) has substantial limitations. The superior spatial resolution of optical coherence tomography (OCT) could translate into meaningful clinical benefits. We aimed to compare angiographic guidance alone versus angiographic plus OCT guidance for PCI. Methods and results: Patients undergoing PCI with angiographic plus OCT ...
- - 2012
In 1988, the World Health Assembly resolved to eradicate polio, which led to the establishment of the Global Polio Eradication Initiative (GPEI). In 2012, however, the transmission of indigenous wild poliovirus (WPV) continued uninterrupted in Afghanistan, Pakistan, and Nigeria, leading the World Health Assembly to declare completion of polio eradication ...
- - 2012
On July 8, 2012, a U.S. resident was admitted to a hospital in Dubai, United Arab Emirates, for evaluation of right arm spasticity, anxiety, and malaise. By the next day, the patient had become comatose following a period of agitation. On July 31, he died. Investigators from CDC, state, and ...
- - 2012
During January 2012, the Puerto Rico Department of Health (PRDOH) detected a tuberculosis (TB) outbreak among residents of a long-term-care facility in the San Juan metropolitan area. The same rare Mycobacterium tuberculosis genotype was identified in isolates from four patients. This facility housed 40 men, aged 40-71 years, with severe ...
- - 2012
During May 20-September 22, 2012, the United States experienced low levels of seasonal influenza activity overall; however, more seasonal influenza viruses were detected than in the summer months of previous years. Influenza A (H1N1)pdm09 (pH1N1), influenza A (H3N2), and influenza B viruses were detected worldwide and were identified sporadically in ...
- - 2012
Foodborne botulism is a rare, potentially fatal paralytic illness caused by eating food contaminated by Clostridium botulinum toxin. It occurs most often as a single case not linked to others by a common food source. As a result of improvements in food canning, when outbreaks do occur, they typically involve ...
Blanquart François - - 2012
Time-shift experiments provide measures of the mean fitness of a population in environments of different points in time. Here, we show how to use this type of data to decompose mean fitness into (1) the effect of the environment in which the population is transplanted, (2) the effect of the ...
Ware James H - - 2012
The statistical consultants to the Journal provide guidance on missing data in reports submitted for publication.
Pravaz Olivier - - 2012
The synthesis via in situ polymerization and characterization of nanocomposites (NCs) made from silica (SiO(2)) nanoparticles in a methyl methacrylate (MMA) monomer matrix is reported. We first investigate the transfer of well-defined spherical silica nanoparticles (NPs) (average radius R = 24.2 ± 3.2 nm) into the monomer solvent. We study ...
Jones Lisa - - 2012
Polycyclic aromatic hydrocarbons (PAHs) are commonly occurring environmental pollutants, 8 of which have been chosen from the list of priority substances in the EU Water Framework Directive (WFD). The levels of PAHs in the environment are affected by a number of emission factors including anthropogenic activities, population equivalents, and weather, ...
Rahman Momotazur M Center for Gerontology & Health Care Research, Brown University, Providence, RI 02912, USA. - - 2013
To examine the effect of reductions in hospital-based (HB) skilled nursing facility (SNF) bed supply on the rate of rehospitalization of patients discharged to any SNF from zip codes that lost HB beds. We used Medicare enrollment records, Medicare hospital and SNF claims, and nursing home Minimum Dataset assessments and ...
Gutensohn K - - 2012
INTRODUCTION: Anti-cardiolipin and β2-glycoprotein I antibodies represent important diagnostic parameters in routine hematology. In this study, five different automated, semi-automated, and manual immunoassays detecting IgG/IgM anti-cardiolipin and anti-β(2) -glycoprotein I antibodies were tested. METHODS: A total of 162 samples from women with a history of miscarriage were recruited from 110 ...
Wims C M - - 2012
The objective of this experiment was to investigate the effect of four perennial ryegrass cultivars: Bealey, Astonenergy, Spelga and AberMagic on the milk yield and milk composition of grazing dairy cows. Two 4 × 4 latin square experiments were completed, one during the reproductive and the other during the vegetative ...
Silva Diana - - 2012
Background. Statins are known for their lipid-lowering effects and role in the treatment of atherosclerotic disease. They also have anti-inflammatory and immunomodulatory properties which could benefit asthma patients. We aimed to review the evidence on the efficacy and safety of statins in asthma-related outcomes. Methods. A systematic review of the ...
Paterson Colin R - - 2012
To the Editor: In a recent pooled analysis of vitamin D dose requirements for fracture prevention, Bischoff-Ferrari and colleagues (July 5 issue)(1) reanalyzed data from clinical trials by taking into account vitamin D supplementation taken by participants in addition to the study medication. This reanalysis provides a more accurate estimation ...
Morris Andrea M - - 2012
The hippocampus is involved in encoding and integrating contextual information. Recently, it has been suggested that the dorsal dentate gyrus (dDG) hippocampal subregion may mediate the formation of contextual representations of the spatial environment through a conjunctive encoding process whereby incoming multimodal information is integrated into a single higher-order representation. ...
Levcik D - - 2012
Rat hippocampus plays a crucial role in many spatial tasks, including recognition of position of objects, which can be approached and explored. Whether hippocampus is also necessary for recognizing positions of objects located in an inaccessible part of the environment remains unclear. To address this question, we conditioned rats to ...
Pfefferbaum Betty - - 2012
Clinical work and research relative to child mental health during and following disaster are especially challenging due to the complex child maturational processes and family and social contexts of children's lives. The effects of disasters and terrorist events on children and adolescents necessitate diligent and responsible preparation and implementation of ...
Thoi V Sara - - 2012
Growing global energy demands and climate change motivate the development of new renewable energy technologies. In this context, water splitting using sustainable energy sources has emerged as an attractive process for carbon-neutral fuel cycles. A key scientific challenge to achieving this overall goal is the invention of new catalysts for ...
Wang Ping - - 2012
We have developed a microcantilever based sensor array which can be functionalized with mercapto-compounds to detect proteins. Linear discriminant analysis (LDA) is used to differentiate the cantilever deflection patterns. It is concluded that more sensors give better separating capacity and the COOH and Si-OCH(3) groups are important factors in protein ...
Gabutti Luca - - 2012
To the Editor: Kang et al. (June 28 issue)(1) report significantly better outcomes with early surgery than with conventional treatment in patients with infective endocarditis and vegetations with a diameter greater than 10 mm. More than 90% of the patients in their study had severe aortic-valve or mitral-valve regurgitation; however, ...
Ning H - - 2012
In erectile dysfunction (ED) research, monocultures of cavernous endothelial cells (CECs) and smooth muscle cells (CSMCs) have been reported, but a CEC-CSMC coculture system is still lacking. In the present study, we wished to investigate the feasibility of setting up such a system and test whether it can be used ...
Wu Yuangen - - 2012
Aptamer-assembled nanomaterials have captured much attention from the field of analytical chemistry in recent years. Although they have been regarded as a promising tool for heavy metal monitoring, report involving aptamer-based biosensors for arsenic detection are rare. Herein we developed a highly sensitive and selective aptamer biosensor for As(iii) detection ...
Lin Lan - - 2012
Small animal magnetic resonance microscopy (MRM) has been widely used today in computational neuroanatomy. Accurate identification of brain tissue in a mouse MRM is a critical fundamental step in neuroimaging processing, which is given less attention. This study presents an automatic skull-stripping technique based on template models and histogram analysis. ...
Opanasopit Praneet - - 2012
The aim of this study was to prepare, characterize and evaluate electrospun polyvinyl alcohol (PVA) and cellulose acetate (CA) nanofibers loaded with capsicum extract (CE) for use in topical skin treatments. CE, 0.5, 1 or 2 wt %, was loaded into PVA and CA electrospun fiber mats. Various properties of ...
Balas A - - 2012
Two novel HLA-B alleles were characterized. HLA-B*37:34 shows two nucleotide differences regarding B*37:10 at codons 79 (CGC>CGG) and 80 (ACC>ATC), resulting in one amino acid replacement at position 80 (T>I). HLA-B*44:152 differs from B*44:02:01 in one nucleotide at codon 81 (GCG>ACG) giving rise to a leucine to threonine substitution at ...
Asmare K - - 2012
SUMMARY Abortion and stillbirth are important reproductive disorders in the dairy industry and are often caused by infectious agents. This study investigated whether bovine viral diarrhoea virus (BVDV), Brucella spp., and Neospora caninum are associated with abortion and/or stillbirth in dairy cattle in Ethiopia. Dairy cattle from 99 farms were ...
Hearst Mary O - - 2012
OBJECTIVE: To refine and validate an existing home food inventory (HFI) for low-income Somali- and Spanish-speaking families. DESIGN: Formative assessment was conducted using two focus groups, followed by revisions of the HFI, translation of written materials and instrument validation in participants' homes. SETTING: Twin Cities Metropolitan Area, Minnesota, USA. SUBJECTS: ...
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