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Williams Kelli W - - 2012
Asthma is the most common chronic condition affecting children and a prominent chief complaint in pediatric emergency departments (ED). We aimed to determine parental preference between short- and long-term courses of oral corticosteroids for use in children with mild to moderate asthma presenting to our pediatric ED with acute asthma ...
Green Matthew Hobson - - 2012
In many animals, limb movements transition between gait patterns with increasing locomotor speed. While in for tetrapod systems, several well-developed models in diverse taxa (e.g. cat, mouse, salamander, turtle) have been used to study motor control of limbs and limb gaits, virtually nothing is known from fish species, including zebrafish, ...
Raynaud-Simon Agathe - - 2012
AIMS/HYPOTHESIS: Diabetic patients with wounds are at risk of protein malnutrition, have low arginine plasma levels and suffer from delayed wound healing. We sought to determine the efficacy of arginine plus proline supplementation on protein and amino acid metabolism and on wound repair in a model of diabetic rats. METHODS: ...
Chen Henry H - - 2012
A 15-month-old female child presented with progressive right-sided facial swelling, nasal obstruction, and deviation of the nose to the left. Computed tomography revealed a cystic mass in the maxillary sinus with disruption of the medial orbital floor. Incisional biopsy of this mass was nondiagnostic and the mass continued to grow ...
Duong Dinh Loc - - 2012
Grain boundaries in graphene are formed by the joining of islands during the initial growth stage, and these boundaries govern transport properties and related device performance. Although information on the atomic rearrangement at graphene grain boundaries can be obtained using transmission electron microscopy and scanning tunnelling microscopy, large-scale information regarding ...
Ilies Laurean - - 2012
Diarylalkynes are chemo- and stereoselectively hydromagnesiated in high yields at room temperature with an iron hydride species generated in situ from FeCl2 and EtMgBr. Functional groups such as bromide, iodide, amine, hydroxyl, and alkene are well tolerated. Under similar conditions, diynes are chemo-, regio-, and stereoselectively hydromagnesiated. The resulting alkenylmagnesium ...
Uka Takanori - - 2012
What are the neural mechanisms underlying improvement in perceptual performance due to learning? A recent study using motion-direction discrimination suggested that perceptual learning is due to improvements in the "readout" of sensory signals in sensory-motor cortex and not to improvements in neural sensitivity of the sensory cortex. To test the ...
Cook Douglas J - - 2012
Over decades, all attempts to translate acute stroke neuroprotectants from discovery in lower-order species to human clinical use have failed. This raised concerns about the predictive validity of preclinical studies in animals for outcomes in human stroke trials. To bridge this translational gap, we used high-order gyrencephalic nonhuman primates subjected ...
Chamoun Roukoz - - 2012
Objective With the increasing use of the endoscope in neurosurgery, transsphenoidal surgery has undergone a considerable technical evolution. However, most recently reported advances relate to the approach to the sella turcica or to extended transsphenoidal approaches, whereas the dissection technique for pituitary tumor removal itself has received more limited attention. A ...
Cui Xiaohong - - 2012
PURPOSE: To compare the conventional localized point-resolved spectroscopy (PRESS) with localized 2D intermolecular single-quantum coherence (iSQC) magnetic resonance spectroscopy (MRS) and obtain in vivo MRS spectrum of rat brain using the latter technique. MATERIALS AND METHODS: A brain phantom, an intact pig brain tissue, and mature Sprague-Dawley rat were studied ...
Bartlett Ruth - - 2012
Debates about involving people with dementia in qualitative research are extensive, yet the range of methods used is limited. Researchers tend to rely on interview and/or observation methods to collect data, even though these tools might preclude participation. I modified the conventional diary interview method to include photo and audio ...
Zhang Guojun - - 2012
Interferon regulatory factor 3 (IRF-3) plays an important role in virus and double-stranded RNA-mediated induction of type I interferon and RANTES (regulated on activation normal T cell expressed and secreted), DNA damage signaling, tumor suppression, and virus-induced apoptosis. IRF-3 had recently been shown to contribute to T cell activation in ...
Takamiya Rina - - 2012
We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure. In this study, we report on the biological significance of the Siglec-15-mediated interaction between monocytes/macrophages and cancer cells. ...
Senner Claire E - - 2012
Embryonic (ES) and epiblast (EpiSC) stem cells are pluripotent but committed to an embryonic lineage fate. Conversely, trophoblast (TS) and extraembryonic endoderm (XEN) stem cells contribute predominantly to tissues of the placenta and yolk sac, respectively. Here we show that each of these four stem cell types is defined by ...
Heyman Jefri - - 2012
Temporal controlled degradation of key cell division proteins ensures a correct onset of the different cell cycle phases and exit from the cell division program. In light of the cell cycle, the Anaphase-Promoting Complex/Cyclosome (APC/C) is an important conserved multi-subunit ubiquitin ligase, marking targets for degradation by the 26S proteasome. ...
Dean Andrea Lach - - 2012
We investigated the feasibility of using mobile phone text messaging (SMS) to promote adherence to antiretroviral therapy among HIV-infected pregnant women recently diagnosed with HIV. Seven HIV-positive women (15-33 weeks gestation) from two urban antenatal clinics received mobile phones and were invited to use text messaging to discuss HIV, health ...
Lu Guo-Ping - - 2012
OBJECTIVE:: To evaluate the effect of continuous blood purification on cardiac function and plasma vasoactive substances in endotoxic shock in piglets. DESIGN:: This was a randomized controlled trial in an animal laboratory in a tertiary care pediatric center. MATERIALS AND METHODS:: Twenty-three healthy Shanghai white piglets weighing 8-14 kg were ...
Franklin Paula - - 2012
Qualitative researchers cannot rely on research ethics to be a static practice. In this article we discuss how observation of guidelines for inquiry and international agreements on the dignity of health care research are not sufficient on their own to ensure that the challenges inherent in the everyday management of ...
Ehret Alexander E - - 2012
In this contribution, we present a constitutive model to describe the mechanical behaviour of microbial biofilms based on classical approaches in the continuum theory of polymer networks. Although the model is particularly developed for the well-studied biofilms formed by mucoid Pseudomonas aeruginosa strains, it could easily be adapted to other ...
Gire Anisa - - 2012
Prosthetic replacement of the ocular surface ecosystem is a treatment developed by the Boston Foundation for Sight that uses a Food and Drug Administration-approved prosthetic device for the treatment of severe ocular surface disease to improve vision and discomfort in addition to supporting the ocular surface. Facial nerve paralysis has ...
Eddy David M - - 2012
The Medicare Shared Savings Program, created under the Affordable Care Act, will reward participating accountable care organizations that succeed in lowering health care costs while improving performance. Depending on how the organizations perform on several quality measures, they will "share savings" in Medicare Part A and B payments-that is, they ...
Monlleo-Neila Laura - - 2012
The mitochondrial DNA m.13513G>A mutation in the ND5 subunit gene is a frequent cause of Leigh syndrome. Patients harboring this mutation typically present with ptosis and cardiac conduction abnormalities, particularly Wolff-Parkinson-White syndrome, and have a late clinical onset, which contrasts with the typical infantile form. The authors describe a patient ...
Ketusing N - - 2012
Several strategies for eradicating Pseudorabies virus (Aujeszky's disease) in Chiang-Mai and Lampoon Provinces, Thailand, were compared using a computer simulation model, the North American Animal Disease Spread Model (NAADSM). The duration of the outbreak, the number of affected herds and the number of destroyed herds were compared during these simulated ...
Boyd D A - - 2012
OBJECTIVES: To date no complete genetic structure of acquired DNA harbouring a d-Ala-d-Ser operon in an Enterococcus is known. We wished to characterize the acquired DNA harbouring the vanE operon located in the Enterococcus faecalis N00-410 chromosome. METHODS: Whole genome sequencing of E. faecalis N00-410 was conducted by massively parallel ...
Huang Xuehui - - 2012
Crop domestications are long-term selection experiments that have greatly advanced human civilization. The domestication of cultivated rice (Oryza sativa L.) ranks as one of the most important developments in history. However, its origins and domestication processes are controversial and have long been debated. Here we generate genome sequences from 446 ...
Bent Franziska - - 2012
Although studies have evaluated the efficacy of levosimendan in heart failure during sepsis, it still is a subject of controversy whether levosimendan produces an effect on platelets. In this study, the short- and long-term effects of levosimendan on platelet aggregation were investigated in untreated animals and in a rat model ...
Boisselier Blandine - - 2012
OBJECTIVE: The IDH1(R132H) mutation is both a strong prognostic predictor and a diagnostic hallmark of gliomas and therefore has major clinical relevance. Here, we developed a new technique to detect the IDH1(R132H) mutation in the plasma of patients with glioma. METHODS: Small-size DNA (150-250 base pairs) was extracted from the ...
Seashols Sarah J - - 2012
Luminol, Bluestar(®) , and Hemascein(®) were tested to compare detection sensitivities to latent blood. Untreated, EDTA-treated human blood, and a catalytically similar blood substitute were diluted (neat to 1:1,000,000) and pipetted onto a variety of substrates. Luminol and Bluestar(®) performed similarly on all surfaces and fabrics. Hemascein(®) yielded poor results ...
Hao Qingzhen - - 2012
Knowledge of the past variability of climate at high northern latitudes during astronomical analogues of the present interglacial may help to inform our understanding of future climate change. Unfortunately, long-term continuous records of ice-sheet variability in the Northern Hemisphere only are scarce because records of benthic (18)O content represent an ...
Itou Junji - - 2012
Adult zebrafish possess a significant ability to regenerate injured heart tissue through proliferation of pre-existing cardiomyocytes, which contrasts with the inability of mammals to do so after the immediate postnatal period. Zebrafish therefore provide a model system in which to study how an injured heart can be repaired. However, it ...
Halachev Konstantin - - 2012
ABSTRACT: Epigenome mapping consortia are generating resources of tremendous value for studying epigenetic regulation. To maximize their utility and impact, new tools are needed that facilitate interactive analysis of epigenome datasets. Here we describe EpiExplorer, a web tool for exploring genome and epigenome data on a genomic scale. We demonstrate ...
LysoƄ Tomasz - - 2012
Introduction Traditionally retrobulbar lesions localized in the medial part of the orbit are removed using rather extensive extracranial approaches. A few cases were recently reported in which lesions of a certain type were removed using a transnasal endoscopic approach. We describe a patient in whom we managed to remove a sizable ...
Heine G - - 2012
Background:  Vitamin D mediates immunomodulatory functions and beneficial functions in allergic diseases have been suggested. Vitamin D receptor (VDR) gene polymorphisms are known but have not been studied in atopic dermatitis (AD) patients yet. Objective: We investigated the frequency of 4 common VDR gene polymorphisms in AD patients and their ...
Margrove Kerrie L - - 2012
Aims:The potential for participation in creative activity to promote recovery from mental ill health is highlighted in mental health policy and guidance, alongside a perceived dearth of robust evidence of effectiveness. Open Arts has run participatory arts courses in South Essex since 2008 and a course waiting list has developed ...
Meng Ran - - 2012
OBJECTIVE: This study aims to evaluate protective effects of brief repetitive bilateral arm ischemic preconditioning (BAIPC) on stroke recurrence in patients with symptomatic atherosclerotic intracranial arterial stenosis (IAS). METHODS: A total of 68 consecutive cases with symptomatic IAS, diagnosed by imaging, were enrolled in this prospective and randomized study. All ...
Bhatti Parveen - - 2012
In this issue of the Journal, Parent et al. (Am J Epidemiol. 2012;000(0):000-000) report significant associations between night-shift work and risk of cancer at several sites among men. These findings not only address the need for shift-work studies that evaluate cancers other than breast and prostate cancer but also support ...
Bo Simona - - 2012
BACKGROUND: There are few prospective data on the prognosis of insulin-sensitive and insulin-resistant normal-weight (NW) or obese individuals. OBJECTIVES: The estimated liver fat content, incidences of hyperglycemia and cardiovascular disease, and all-cause and cardiovascular mortality rates were investigated in a population-based cohort of 1658 individuals who were categorized according to ...
Clyne Alisa M - - 2012
In this case study, an early-career mechanical engineer interviews an established translational bioscientist about mechanisms for merging engineering and biomedicine to pursue clinically informed research questions.
Ku Manching - - 2012
ABSTRACT: BACKGROUND: The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. However, the relationships among these seemingly disparate functions remain obscure. RESULTS: We mapped H2A.Z genome-wide in mammalian ES cells and neural progenitors. H2A.Z is deposited promiscuously at promoters and enhancers, and correlates strongly ...
Kato Shiro - - 2012
Oenococcus oeni, a lactic acid bacterium, possesses a lysine racemase, which has a specific activity toward basic amino acids. A comparison of amino acid residues around the active site suggested that Ile222 and Tyr354 of the Geobacillus stearothermophilus alanine racemase, which shares 60% sequence similarity with lysine racemase, were replaced ...
Zhang Peng - - 2012
Hypoxia inducible factors 1-3 (HIF1-3) are transcription factors that regulate gene expression in response to hypoxia. Compared to our extensive understanding of HIF-1 and -2, our knowledge of HIF-3 is limited. In this study, we characterized the zebrafish hif-3α gene and determined its temporal and spatial expression, physiological regulation, and ...
Bourdette Dennis - - 2012
Unexpected consequences arise from our incomplete knowledge of the immune system. Who, for example, would have predicted that natalizumab, a monoclonal antibody targeting α4 integrin on leukocytes, would dramatically increase the risk of developing progressive multifocal leukoencephalopathy without causing notable immunosuppression? Thus, any new immunomodulatory therapy in humans must be ...
Hansen Kasper D - - 2012
ABSTRACT: DNA methylation is an important epigenetic modification involved in gene regulation, which can now be measured using whole-genome bisulfite sequencing. However, cost, complexity of the data, and lack of comprehensive analytical tools are major challenges that keep this technology from becoming widely applied. Here we present BSmooth, an alignment, ...
Garnett Aaron T - - 2012
Neural crest cells generate a range of cells and tissues in the vertebrate head and trunk, including peripheral neurons, pigment cells, and cartilage. Neural crest cells arise from the edges of the nascent central nervous system, a domain called the neural plate border (NPB). NPB induction is known to involve ...
Kitamura Tetsuhisa - - 2012
BACKGROUND: Little is known about the nationwide trend in the survival of out-of-hospital cardiac arrest (OHCA) in Japan and the differences in incidence and survival by age group and origin of arrest. METHODS AND RESULTS: A nationwide, prospective, population-based observation covering the whole population of Japan and involving consecutive OHCA ...
Overby Nina Cecilie - - 2012
BACKGROUND: A diet high in fruit and vegetables (FV) is inversely related to chronic diseases, and some studies suggest that increasing the intake of FV reduces the intake of unhealthy snacks. OBJECTIVES: The objectives were to analyze changes in the frequency of consumption of unhealthy snacks (soda, candy, and potato ...
Reitman Aaron J - - 2012
Background. Our objective was to evaluate serial procalcitonin (PCT) levels compared with an initial PCT level at admission in predicting bacteremia in pediatric febrile neutropenic oncology patients. Procedure. Serum PCT levels were measured at admission (t0) and within 24 hours of admission (t1) in pediatric oncology patients presenting with fever ...
Schweigert Michael - - 2012
Objective Necrotizing pneumonia, pulmonary abscess, and lung gangrene are rare complications of severe pulmonary infection with devitalization and sloughing of lung tissue. Pulmonary necrosis is often associated with alcoholism and other chronic disorders with known immunodeficiency. Mortality is significant and both treatment strategies as well as the role of surgery are ...
Gohil S - - 2012
We report a case of neuropathic pain following peripheral venous cannulation for an elective surgical procedure and discuss the various mechanisms by which this could occur. The mostly likely trigger in this case is phlebitis as the onset of symptoms coincided with the local infection. Neuropathic pain can occur following ...
Buoli Massimiliano - - 2012
BACKGROUND: Several studies show an association between a long duration of untreated illness (DUI) and poor outcome in schizophrenic patients. DUI, in turn, may be influenced by different variables including specific illness-related factors as well as access to local psychiatric services. AIMS: The purposes of the present study were to ...
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