Search Results
Results 451 - 500 of 1352
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Frasch Karel - - 2012
BACKGROUND: Physical comorbidities and substance use are commonly reported in patients with mental disorders. AIM: To examine somatic comorbidity in patients with substance use disorders (SUD) compared to patients with mental disorders but no SUD. METHODS: Lifetime prevalence data on mental and physical health status were collected from inpatients in ...
Thomson John P - - 2012
ABSTRACT: BACKGROUND: Induction and promotion of liver cancer by exposure to non-genotoxic carcinogens coincides with epigenetic perturbations, including specific changes in DNA methylation. Here we investigate the genome-wide dynamics of 5-hydroxymethylcytosine (5hmC) as a likely intermediate of 5-methylcytosine (5mC) demethylation in a DNA methylation reprogramming pathway. We use a rodent ...
Davis Kathleen - - 2012
Sjögren-Larsson syndrome is an inherited disorder of lipid metabolism caused by mutations in the ALDH3A2 gene that codes for fatty aldehyde dehydrogenase, which results in accumulation of fatty aldehydes and alcohols and is characterized by ichthyosis, intellectual disability, and spastic diplegia/quadriplegia. The authors describe 2 unrelated Honduran patients who carried ...
Horvath Steve - - 2012
ABSTRACT: BACKGROUND: Several recent studies reported aging effects on DNA methylation levels of individual CpG dinucleotides. But it is not yet known whether aging related consensus modules, in the form of clusters of correlated CpG markers, can be found that are present in multiple human tissues. Such a module could ...
Liu Fei - - 2012
p21 (Cip1/CDKN1A) and p27 (Kip1/CDKN1B) are members of the Cip/Kip family of cyclin-dependent kinase inhibitors, which can arrest cell proliferation and serve as tumor suppressors. We hypothesized that genetic variants in p21 and p27 may modify individual susceptibility to hepatocellular carcinoma (HCC). To test this hypothesis, we evaluated the associations ...
Wiet Richard J - - 2012
ObjectiveTo compare short- and long-term hearing results following stapedectomy using 3 different oval window grafting materials with the same stapes prosthesis.Study DesignDatabase review.SettingTertiary referral private practice.Subjects and MethodsSubjects were ears that underwent stapedectomy for otosclerosis, with placement of fat, fascia, or vein as an oval window seal and reconstruction with ...
Hao Weidong - - 2012
Human rhinovirus species C (HRV-C) was recently discovered using molecular diagnostic techniques and is associated with lower respiratory tract disease, particularly in children. HRV-C cannot be propagated in immortalized cell lines, and currently sinus organ culture is the only system described that is permissive to HRV-C infection ex vivo. However, ...
Lee Seung Woo - - 2012
Transition metal oxide and phosphate materials, commonly used for lithium battery devices, are active as oxygen evolution reaction (OER) catalysts under alkaline and neutral solution conditions. Electrodes comprised of LiCoO(2) and LiCoPO(4) exhibit progressive deactivation and activation for OER catalysis, respectively, upon potential cycling at neutral pH. Deactivation of LiCoO(2) ...
Delemer Brigitte - - 2012
To document the initial management of hypothyroidism in France with respect to diagnostic setting, investigations, and therapeutic approach. Observational study of the management by primary care practitioners (PCPs) and endocrinologists of patients diagnosed with, and treated for, hypothyroidism during the enrollment period or the previous 6 months. A representative sample ...
Mei May Lei - - 2012
OBJECTIVE: To determine the short-term stability of free fluoride ion concentrations and acidity (pH values) of three commercially available SDF solutions over time. METHODS: Three SDF products for caries control were studied: Cariestop-12%, Cariestop-30% and Saforide-38%. Their expected fluoride ion concentrations were 14,200, 35,400 and 44,800 ppm, respectively. The fluoride ion ...
Arnason Barry G - - 2012
The therapeutic benefits of adrenocorticotropic hormone in multiple sclerosis are usually ascribed to its corticotropic actions. Evidence is presented that adrenocorticotropic hormone, approved for multiple sclerosis relapses, acts via corticosteroid-independent melanocortin pathways to engender down-modulating actions on immune-system cells and the cytokines they synthesize. Immune response-dampening effects are also brought ...
Hung Yu-Shin - - 2012
This study aimed to compare multiaspect characteristics in cancer and noncancer patients who received palliative care. Totally, 226 patients with cancer and 115 noncancer patients received palliative care consultation service in Taiwan from September 2007 through December 2009 were retrospectively analyzed. Noncancer patients were older (81 vs 67 years, P ...
Mavrogeni S - - 2012
Objective: The objective of this paper is to evaluate the diagnostic role of cardiac magnetic resonance imaging (CMR) in detecting myocardial inflammation in systemic lupus erythematosus (SLE) and its differentiation from viral myocarditis.Patients and methods: Fifty patients with suspected infective myocarditis (IM), with chest pain, dyspnoea or altered ECG, increase ...
Adriaenssens Bart - - 2012
Individuals often show consistent behavioural differences where behaviours can form integrated units across functionally different contexts. However, the factors causing and maintaining behavioural syndromes in natural populations remain poorly understood. In this study, we provide evidence for the emergence of a behavioural syndrome during the first months of life in ...
Wild Conor J CJ Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada, K7L 3N6. - - 2012
The conditions of everyday life are such that people often hear speech that has been degraded (e.g., by background noise or electronic transmission) or when they are distracted by other tasks. However, it remains unclear what role attention plays in processing speech that is difficult to understand. In the current ...
Pezzullo Margherita - - 2012
Here we report a comprehensive analysis through alanine-scanning mutagenesis of the contribution of surface ion pairs to the thermal stability of Alicyclobacillus acidocaldarius esterase 2 (EST2). We produced 16 single mutants, 4 double mutants corresponding to selected ion pairs R31/E118, E43/K102, R58/D130, D145/R148, 2 double mutants (R63A/R98A and E50A/D94A) involving ...
Stocchi F - - 2012
BACKGROUND: The Move for Change campaign is a three-part series of pan-European surveys designed by the European Parkinson's Disease Association (EPDA) to assess the impact that the EPDA Charter for People with Parkinson's disease (PD) has had since its launch in 1997. Here, we report results from the second survey, ...
Lokugamage Nandadeva - - 2012
Rift Valley fever virus strain MP-12 was generated by serial plaque passages of parental strain ZH548 12 times in MRC-5 cells in the presence of a chemical mutagen, 5-fluorouracil. As a result, MP-12 encoded 4, 9, and 10 mutations in the S, M, and L segments, respectively. Among them, mutations ...
Ure Agustín Enrique - - 2012
Methylation of the high-risk human papillomavirus type 16 (HPV16) upstream regulatory region (URR) has been described, but whether methylation is present among low-risk HPVs is unknown. The methylation status of the HPV6 URR was analyzed in papillomas from the upper aerodigestive tract of six adult patients. All CpGs in the ...
Rasilainen S K - - 2012
BACKGROUND: Several temporary abdominal closure techniques have been used in the management of open abdomen. Failure to achieve delayed primary fascial closure results in a large ventral hernia. This retrospective analysis evaluated whether the use of vacuum-assisted closure and mesh-mediated fascial traction (VACM) as temporary abdominal closure improved the delayed ...
Overdevest I T M A - - 2012
Multilocus sequence typing (MLST) is one of the most reliable methods for typing of Escherichia coli, including extended-spectrum-β-lactamase-producing E. coli (ESBL-EC). We investigated the performance of a new typing method, SpectraCell RA (River Diagnostics, Madison, WI), in comparison on MLST on a well-defined collection of ESBL-EC isolates obtained from chicken ...
Antrobus Shane P SP Dept. of Physiology and Membrane Biology, School of Medicine, Univ. of California, Davis, CA 95616, - - 2012
Using antibodies prepared against a unique region (exon 22-24) of rat K(+)-Cl(-) cotransporter-2 (KCC2), we confirmed that the ~140-kDa KCC2 protein is exclusively expressed in rat brain, but in chicken, we observed strong reactivity not only with the ~140-kDa KCC2 protein in brain but also a slightly larger ~145-kDa protein ...
Armenian Saro H SH Department of Population Sciences, City of Hope, 1500 E. Duarte Rd, Duarte, CA 91010-3000, USA. - - 2012
Hematopoietic cell transplantation (HCT) recipients may be at an increased risk of developing hypertension, diabetes, and dyslipidemia (referred to as cardiovascular risk factors [CVRFs]); and these factors can potentially increase the risk of cardiovascular disease (CVD). We examined the incidence and predictors of CVRFs and subsequent CVD in 1885 consecutive ...
Yao Dan D Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108, - - 2013
Rodent animal models have been widely used for studying neurologic and toxicological events associated with cocaine abuse. It is known that the mouse is more susceptible to cocaine-induced hepatotoxicity (CIH) than the rat. However, the causes behind this species-dependent sensitivity to cocaine have not been elucidated. In this study, cocaine ...
Farley Brian M - - 2012
RNA-binding proteins (RBPs) coordinate cell fate specification and differentiation in a variety of systems. RNA regulation is critical during oocyte development and early embryogenesis, in which RBPs control expression from maternal mRNAs encoding key cell fate determinants. The Caenorhabditis elegans Notch homologue glp-1 coordinates germline progenitor cell proliferation and anterior ...
Yi Huanfa - - 2012
Myeloid-derived suppressor cells (MDSCs) have been a focus of recent study on tumor-mediated immune suppression. However, its role in Th17 cell differentiation and the pathogenesis of autoimmune diseases (e.g., multiple sclerosis) has not been determined. We show in this study that development of experimental autoimmune encephalomyelitis (EAE) in mice is ...
Lara-Palomo Inmaculada Carmen - - 2012
Objectives:To analyse the effectiveness of a combined procedure of massage and electrotherapy with interferential current in individuals with chronic non-specific low back pain of mechanical aetiology.Design:A single blinded randomized controlled trial.Setting:Clinical setting.Participants:Sixty-two individuals with chronic non-specific low back pain were randomly assigned to an experimental or control group. For 10 ...
Cunningham Melissa D MD Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, - - 2012
Wapl protein regulates binding of the cohesin complex to chromosomes during interphase and helps remove cohesin from chromosomes at mitosis. We isolated a dominant mutation in wapl (wapl(AG)) in a screen for mutations that counteract silencing mediated by an engrailed Polycomb-group response element. wapl(AG) hemizygotes die as pharate adults and ...
Akalin Altuna - - 2012
ABSTRACT: DNA methylation is a chemical modification of cytosine bases that is pivotal for gene regulation, cellular specification and cancer development. Here, we describe an R package, methylKit, that rapidly analyzes genome-wide cytosine epigenetic profiles from high-throughput methylation and hydroxymethylation sequencing experiments. methylKit includes functions for clustering, sample quality visualization, ...
Rabizadeh Shervin S Cedars-Sinai Medical Center, Los Angeles, CA 90077, USA. - - 2012
Morbidity and Mortality conference (MMC) serves an important role in medical care and education. We restructured our Department of Pediatrics MMC to focus on multidisciplinary participation and improved communication among disciplines, quality improvement, and system changes for safer clinical care and enhanced learning from adverse outcomes. The structure and philosophy ...
Söffker Marta - - 2012
Genetic variation has a significant effect on behavior, fitness, and response to toxicants; however, this is rarely considered in ecotoxicological studies. We compared fitness-related behavioral traits, breeding activity, and the effects of exposure to the environmental estrogen ethinylestradiol (EE(2)) on reproduction in a laboratory (Wild Indian Karyotype, WIK) strain and ...
Mitchell Jonathan K - - 2012
The baculovirus Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) initiates apoptosis in diverse insects through events triggered by virus DNA (vDNA) replication. To define the proapoptotic pathway and its role in antivirus defense, we investigated the link between the host's DNA damage response (DDR) and apoptosis. We report here that AcMNPV elicits ...
Guldimann Claudia - - 2012
The significance of atypical bovine spongiform encephalopathies (BSE) in cattle for controlling the BSE epidemic is poorly understood. Here we report a case of atypical H-type BSE in a cow born after the implementation of the reinforced feed ban in Europe. This supports an etiology of H-type BSE unrelated to ...
Kataoka T - - 2012
We developed a new triangular fibrocartilage complex reconstruction technique for distal radioulnar joint instability in which the palmar portion of the triangular fibrocartilage complex was predominantly reconstructed, and evaluated whether such reconstruction can restore stability of the distal radioulnar joint in seven fresh cadaver upper extremities. Distal radioulnar joint instability ...
Paraskevis Dimitrios - - 2012
Whether response to combination antiretroviral therapy (cART) differs between those infected with HIV-1 subtype A or B, remains unclear. We compared virologic and immunologic response to cART in individuals infected with subtype A or B in an ethnically homogenous population. Data derived from the Athens Multicenter AIDS Cohort Study (AMACS) ...
Linzenbold Walter W Centre for Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, Centre for Integrative Neuroscience, Eberhard Karls University, 72076 Tübingen, - - 2012
Neurophysiological studies in nonhuman species indicated that neurons in the superior colliculus (SC) are involved in the control of upper limb movements. These findings suggested that the SC represents a crucial hub in a general sensorimotor network, including skeletomotor as much as oculomotor functions. In contrast to the SC in ...
Le Bastard Nathalie - - 2012
The current treatment for Alzheimer's disease (AD) is purely symptomatic, but medications interfering with underlying pathophysiological processes are being developed. To evaluate a possible disease-modifying effect, cerebrospinal fluid (CSF) biomarkers with a direct link to the underlying pathophysiology, such as amyloid-β1-42 (Aβ1-42), total tau protein (T-tau), and hyperphosphorylated tau (P-tau181P), ...
Buys David R DR Center for Outcomes and Effectiveness Research and Education, University of Alabama at Birmingham UAB, Birmingham, Alabama. - - 2013
Aging adults face an increased risk of adverse health events as well as risk for a decrease in personal competencies across multiple domains. These factors may inhibit the ability of an older adult to age in place and may result in a nursing home admission (NHA). This study combines insights ...
Darvish-Kazem Saeed - - 2012
Patients receiving anticoagulant or antiplatelet therapy who require noncardiac surgery represent a common yet challenging clinical problem. Clinicians must balance the risk of thromboembolic and major adverse cardiovascular events that are associated with interrupting these therapies, against the risk of bleeding from continuing these drugs in the perioperative period. Identifying ...
Ng Lih Chyuan - - 2012
Previous studies in pulmonary artery smooth muscle cells (PASMCs) showed that acute hypoxia activates capacitative Ca(2+) entry (CCE) but the molecular candidate(s) mediating CCE caused by acute hypoxia remain unclear. The present study aimed to determine if TRPC1 and Orai1 interact with STIM1 and mediate CCE caused by acute hypoxia ...
Cowie B - - 2012
BACKGROUND: /st>Developments in transducer technology have enabled the use of three-dimensional transoesophageal echocardiography (3D TOE) in the operating theatre. Transthoracic echocardiography (TTE) 3D left ventricular (LV) volumes and ejection fraction (EF) agree better with magnetic resonance imaging (MRI) measurements, with less intra- and inter-observer variability compared with 2D. This has ...
Merindol Natacha - - 2012
CMV and varicella zoster virus (VZV) are significant causes of morbidity and mortality following umbilical cord blood transplantation (UCBT). However, the kinetics of reconstitution and protective potential of antiviral cell-mediated immune responses following UCBT remain poorly characterized. In this study, the reconstitution of CMV- and VZV-specific T cell responses was ...
Correale Jorge - - 2012
OBJECTIVE: Our objective was to evaluate risk of exacerbations in multiple sclerosis (MS) patients undergoing assisted reproduction technology (ART) infertility treatment. METHODS: Sixteen patients with relapsing-remitting MS subjected to 26 ART treatment cycles receiving gonadotropin-releasing hormone (GnRH) agonists and recombinant follicle-stimulating hormone were studied prospectively. The baseline study period encompassed ...
LysoƄ Tomasz - - 2012
Introduction Traditionally retrobulbar lesions localized in the medial part of the orbit are removed using rather extensive extracranial approaches. A few cases were recently reported in which lesions of a certain type were removed using a transnasal endoscopic approach. We describe a patient in whom we managed to remove a sizable ...
Heine G - - 2012
Background:  Vitamin D mediates immunomodulatory functions and beneficial functions in allergic diseases have been suggested. Vitamin D receptor (VDR) gene polymorphisms are known but have not been studied in atopic dermatitis (AD) patients yet. Objective: We investigated the frequency of 4 common VDR gene polymorphisms in AD patients and their ...
Margrove Kerrie L - - 2012
Aims:The potential for participation in creative activity to promote recovery from mental ill health is highlighted in mental health policy and guidance, alongside a perceived dearth of robust evidence of effectiveness. Open Arts has run participatory arts courses in South Essex since 2008 and a course waiting list has developed ...
Szafranski Przemyslaw - - 2013
An unanticipated and tremendous amount of the noncoding sequence of the human genome is transcribed. Long noncoding RNAs (lncRNAs) constitute a significant fraction of non-protein-coding transcripts; however, their functions remain enigmatic. We demonstrate that deletions of a small noncoding differentially methylated region at 16q24.1, including lncRNA genes, cause a lethal ...
Comar Manola - - 2012
Many methods with different levels of analytical sensitivity and clinical specificity have been developed to detect the presence of high-risk (HR) types of the human papillomavirus (HPV) in cervical samples. The Hybrid Capture II (HC-II) assay is broadly used for primary screening. In addition, several HPV genotyping assays, based on ...
Xu Miao M National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892, - - 2012
Niemann-Pick disease type C (NPC) and Wolman disease are two members of a family of storage disorders caused by mutations of genes encoding lysosomal proteins. Deficiency in function of either the NPC1 or NPC2 protein in NPC disease or lysosomal acid lipase in Wolman disease results in defective cellular cholesterol ...
Meng Ran - - 2012
OBJECTIVE: This study aims to evaluate protective effects of brief repetitive bilateral arm ischemic preconditioning (BAIPC) on stroke recurrence in patients with symptomatic atherosclerotic intracranial arterial stenosis (IAS). METHODS: A total of 68 consecutive cases with symptomatic IAS, diagnosed by imaging, were enrolled in this prospective and randomized study. All ...
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