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Stier Elizabeth A EA Department of Obstetrics and Gynecology, Boston University Medical Center, Boston, MA, USA. - - 2013
To evaluate the safety and efficacy of topical cidofovir for treatment of high-grade squamous perianal intraepithelial neoplasia (PAIN) and vulvar intraepithelial neoplasia (VIN) lesions in HIV-positive individuals. Phase IIa prospective multicenter trial conducted at eight clinical sites through the AIDS Malignancy Consortium. : HIV-positive patients with biopsy-proven high-grade PAIN that ...
Williams Jessica J Department of Health Services, School of Public Health, University of California, Los Angeles, CA 90024, - - 2013
Despite the rollout of Medicare Part D, cost-related nonadherence (CRN) among older adults remains a problem. To examine the rate and correlates of self-reported CRN among a population of older persons with diabetes. Cross-sectional. A total of 1264 Part D patients with diabetes, who entered the coverage gap in 2006. ...
Vera Jaime H JH Department of Medicine, Section of infectious Diseases, Imperial College London, UK. - - 2013
Positive HLA-B*5701 genotype has recently been identified as the main genetic risk factor for flucloxacillin drug-induced liver injury (DILI). Testing for HLA-B*5701 is routine in many HIV clinics to identify those at risk of hypersensitivity reaction (HSR) to abacavir. Considering the high prevalence of soft-tissue infections in HIV patients, we ...
Thio Chloe L CL Johns Hopkins University, Baltimore, Maryland 21205, USA. - - 2013
To understand the HIV-hepatitis B virus (HBV) epidemic from a global perspective by clinically and virologically characterizing these viruses at the time of antiretroviral therapy (ART) initiation in a multinational cohort. HIV-infected patients enrolled in two international studies were classified as HIV-HBV coinfected or HIV monoinfected prior to ART. HIV-HBV ...
Baheti Gautam G Antiviral Pharmacology Laboratory, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198-6000, - - 2013
There is limited pediatric information on the complex relationships among the dose of tenofovir disoproxil fumarate (TDF), plasma concentrations of tenofovir (TFV), and intracellular TFV diphosphate (TFV-DP) concentrations. Our objectives were to describe TFV-DP pharmacokinetics in children and adolescents and investigate the effect of age on TFV and TFV-DP concentrations. ...
de Silva Thushan I TI Medical Research Council (UK) Laboratories, Fajara, The Gambia. - - 2013
To compare the population dynamics of HIV-2 and HIV-1, and to characterize ongoing HIV-2 transmission in rural Guinea-Bissau. Phylogenetic and phylodynamic analyses using HIV-2 gag and env, and HIV-1 env sequences, combined with epidemiological data from a community cohort. Samples were obtained from surveys in 1989-1991, 1996-1997, 2003 and 2006-2007. ...
Yen Jui-Hung - - 2013
We investigated changes in population and taxonomic distribution of cultivable bacteria and diazotrophs with butachlor application in rice paddy soils. Population changes were measured by the traditional plate-count method, and taxonomic distribution was studied by 16S rDNA sequencing, then maximum parsimony phylogenic analysis with bootstrapping (1,000 replications). The bacterial population ...
Kong Jiansong - - 2013
A study on dechlorination of PCB138 in transformer oil (TO) and 2-propanol (IPA) using 254 nm ultraviolet (UV) light as well as dye sensitized visible light has been conducted. Studies on dechlorination of polychlorinated biphenyls (PCBs) in TO using visible light in the presence of methylene blue (MB) and triethylamine (TEA) ...
Cukurluoglu Sibel - - 2013
Water toxicity originating from the atmospheric deposition of six heavy metals (Cd, Cr, Cu, Ni, Pb, Zn) was investigated on Vibrio fischeri activity in Izmir, Turkey. A LUMIStox® test was applied to dry and wet deposition samples and metal solutions. The inhibition levels and effective toxicity concentrations of these samples ...
Wang Bao-Zhen - - 2013
This article presents a GIS-based multi-source and multi-box modeling approach (GMSMB) to predict the spatial concentration distributions of airborne pollutant on local and regional scales. In this method, an extended multi-box model combined with a multi-source and multi-grid Gaussian model are developed within the GIS framework to examine the contributions ...
Kameda Tomohito - - 2013
A selective catalytic reduction process is generally used to treat NO(x); however, this approach results in the leakage of ammonia and requires expensive catalysts. In light of these issues, the specific objective of this study was to develop a new treatment method for a NO(x) gas stream with a Mg-Al ...
Mleczek Mirosław - - 2013
The aim of this study was to evaluate Cd, Co, Cu, Hg, Ni, Pb, Sr and Zn accumulation in six edible mushroom species and to assess their risk and benefits to human consumers. Mushrooms (Leccinium aurantiacum, Xerocomus badius, Lactarius deliciosus, Boletus edulis, Cantharellus cibarius and Suillus luteus) were collected from ...
Letta Bayessa D - - 2013
Residue levels of organochlorine pesticides (OCP) in a total of 90 cattle samples comprising meat, liver and kidney collected from carcasses slaughtered in six towns in West Shoa Zone, Ethiopia, (Ambo, Guder, Ginchi, Gedo, Holeta and Tikur Inchini), have been determined. The pesticides were extracted by solid phase extraction (SPE) ...
Abdel-Rahman Fawzia H - - 2013
Thirty four phytoterpenoids were evaluated for their nematicidal effect using the model nematode Caenorhabditis elegans. Nematicidal activities of the tested compounds at concentrations of 50 μg/mL showed wide variation in their effects ranging from no effect, weak, moderate and strong effects. Terpenoids exerting 50% or higher mortality at 50 μg/mL were further ...
Chen Jianming - - 2013
With respect to degradation rates and the range in contaminants treated, bimetals such as Ni-Fe or Pd-Fe generally outperform unamended granular iron. However, the catalytic enhancement is generally short-lived, lasting from a few days to months. To take advantage of the significant benefits of bimetals, this study aims at developing ...
Chaudhuri Gouri - - 2013
The study was aimed at investigating the potential use of calf intestinal alkaline phosphatase (CIAP) enzyme in the removal of heavy metals (Cd(2+), Ni(2+), Co(2+) and Cr(3+/6+)) from single ion solutions as well as tannery and electroplating effluents. CIAP mediated bioremediation (white biotechnology) is a novel technique that is eco-friendly ...
Zhang Yan - - 2013
A direct competitive enzyme-linked immunosorbent assay (dc-ELISA) was developed to measure anilofos levels in agricultural and environmental samples. The ELISA was developed using rabbit polyclonal antibodies against a hapten-protein conjugate of anilofos-bovine serum albumin. The limit of detection was 0.1 μg L(-1), and there was no cross-reactivity with other related pesticides ...
Xu Shanwei - - 2013
Composting may be a viable alternative to rendering and land filling for the disposal of specified risk material (SRM) provided that infectious prion proteins (PrP(TSE)) are inactivated. This study investigated the degradation of SRM and the fate of scrapie prions (PrP(Sc)) over 28 days in laboratory-scale composters, with and without feathers ...
Moja Shadung J - - 2013
In this study, mass concentrations and physico-chemical characteristics of suspended particulates of aerodynamic size 10 μm (PM10) were evaluated. A dual E-Sampler which combines the light scatter and the gravimetric filter methods was used. Sampling occurred between August and December 2009. Scanning Electron Microscope - Energy Dispersive Spectrometry (SEM-EDS) and Inductively ...
Benitez F Javier - - 2013
Five emerging contaminants (1-H-Benzotriazole, N,N-diethyl-m-toluamide or DEET, Chlorophene, 3-Methylindole, and Nortriptyline HCl), frequently found in surface waters and wastewaters, were selected to be photooxidized in several water matrices. Previous degradation experiments of these compounds individually dissolved in ultra pure water were performed by using UV radiation at 254 nm and the ...
Perikamana Krishnadas - - 2013
The feasibilities of the adsorbents ferrous modified calcined bauxite (FEMCB) and ferric modified calcined bauxite (FRMCB) in the abatement of Cr(VI) was investigated in the present study. The adsorbents were characterized by scanning electron micrographs (SEM), electro diffraction spectra (EDS), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) spectra. Parameter ...
Wang Li L - - 2013
China's government has prohibited the addition of simply hydrolyzed animal protein from solid leather waste into milk. The objective of this study was to produce a monoclonal antibody against L-hydroxyproline, a special amino acid in hydrolyzed animal protein. L-hydroxyproline was derivatized with N-acetylsulfanilyl chloride and 5-chlorovaleric acid to synthesize the ...
Burga-Perez Karen F - - 2013
Agrochemicals have the potential to cause deleterious effects on living organisms and therefore they must be subjected to various (eco)toxicological studies and monitoring programs in order to protect human health and the environment. The aim of this study was to assess the ecotoxicity of a new natural formicide with a ...
Subashchandrabose Suresh R - - 2013
We isolated strain CERAR5, a Stenotrophomonas sp., from an aquifer contaminated with chlorinated hydrocarbons that utilizes up to 1.0 mM PNP within 62 h in M9 medium as a source of carbon and nitrogen. To assess the potential of this strain for use in bioremediation, we investigated the influence of external sources ...
Ngigi Anastasiah N - - 2013
This study elucidates the effects of carbon amendment on metabolic degradation of atrazine (6-chloro-N(2)-ethyl-N(4)-isopropyl-1,3,5-triazine-2,4-diamine) and total microbial biomass in soil. Degradation of (14)C-ring-labelled atrazine was monitored in laboratory incubations of soils supplemented with 0, 10, 100 and 1000 μg g(-1) sucrose concentrations. An experiment to determine the effect of carbon amendment ...
Hall Lenwood W LW - - 2013
This study used sediment mapping to determine the spatial extent of depositional and non-depositional areas in the wetted stream bed of four urban streams in Salinas, California. After the stream mapping was completed, 8 pyrethroids were analytically measured from randomly selected sites in 12 depositional and 12 non-depositional areas in ...
Castillo-Cadena Julieta - - 2013
The aim of the present work was to determine if the use of pesticide mixtures produced alterations in immunotoxicity biomarkers. The study was undertaken in three groups: the first group consisted of 38 floriculturists, the second comprised 38 vendors of the local market, and the last comprised 33 non-exposed persons ...
Milillo Sara R - - 2013
Control of Listeria monocytogenes in ready-to-eat (RTE) food products is a significant challenge and improved means for control are needed. In this study, the anti-listerial effects of three lactic acid bacteria (LAB) were investigated. Spot-on-lawn assays demonstrated the largest zones of inhibition against L. monocytogenes were produced by the Pediococcus acidilactici ...
Surujlal-Naicker Swastika - - 2013
Wastewater effluents have been documented as major contributors of hormone endocrine disrupting compounds (EDCs) in to the aquatic ecosystem. The need for rapid, simple and cost effective methods to detect these EDCs has increased. The use of Radio-immunoassays (RIA) were assessed to determine the fate of estradiol in a laboratory ...
Miller Edward A EA Department of Gerontology, and Gerontology Institute, McCormack Graduate School of Policy and Global Studies, University of Massachusetts Boston, Boston, MA 02125, USA. - - 2013
The mass media can exert considerable influence over the relative saliency of different public policy concerns. Because emotional resonance can have a strong impact on how the general public and policy makers perceive specific issues, the purpose of this study is to characterize the tone of nursing home coverage in ...
Li Yue Y Department of Community and Preventive Medicine, Division of Health Policy and Outcomes Research, University of Rochester, Rochester, NY 14642, USA. - - 2013
: To determine the effect of postoperative length of stay (LOS) on 30-day readmission after coronary artery bypass surgery. : We analyzed a final database consisting of Medicare claims of a cohort (N=157,070) of all fee-for-service beneficiaries undergoing bypass surgery during 2007-2008, the American Hospital Association annual survey file, and ...
Vadvalkar Shraddha S SS Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, - - 2013
Diabetic cardiomyopathy refers to the changes in contractility that occur to the diabetic heart that can arise in the absence of vascular disease. Mitochondrial bioenergetic deficits and increased free radical production are pathological hallmarks of diabetic cardiomyopathy, but the mechanisms and causal relationships between mitochondrial deficits and the progression of ...
Lemay Jean-François JF Laboratoire de pathokinésiologie, Centre de recherche interdisciplinaire en réadaptation CRIR, Institut de réadaptation Gingras-Lindsay de Montréal IRGLM, H3S 2J4 Montreal, Canada. - - 2013
The aim of this study was to investigate the concurrent validity of the Smart Balance Master (SBM) tests in individuals with incomplete spinal cord injury. Correlational study. Subjects: A total of 32 individuals with an American Spinal Injury Association Impairment Scale D spinal cord injury able to walk 10 m ...
Pommerrenig Benjamin - - 2013
The Arabidopsis SUC5 protein represents a classical sucrose/H(+) symporter. Functional analyses previously revealed that SUC5 also transports biotin, an essential co-factor for fatty acid synthesis. However, evidence for a dual role in transport of the structurally unrelated compounds sucrose and biotin in plants was lacking. Here we show that SUC5 ...
Fourkiotis Verena V Charité University Medicine Berlin, Berlin, - - 2013
Primary aldosteronism (PA) has deleterious effects on kidney function independent of blood pressure levels. Up to now, data on effectiveness of different PA therapies regarding renal function are scarce. This prospective multi-center study included 29 patients with newly diagnosed PA evaluated before and 1 year after treatment initiation, and a ...
Sammon Jesse D - - 2013
Few studies have examined the patient characteristics that lead to early continence after robot-assisted radical prostatectomy (RARP), and to date, there has been no investigation into the predictors of immediate continence. In the current study, we examine a large multisurgeon population of patients undergoing RARP to assess for predictors of ...
Morales-Avila Enrique - - 2012
Radiolabelled nanoparticles conjugated to peptides that target specific molecules can be used as agents for diagnosis. For example, technetium-99m-labelled gold nanoparticles conjugated to the cyclic [Arg-Gly-Asp-Phe-Lys(Cys)] (c[RGDfK(C)]) peptide are used for the molecular imaging of tumour-specific alpha(epsilon)beta(3) expression. Gold nanoparticles (AuNPs, 18-20 nm) are assumed to be safe at the ...
Jordan Melanie - - 2012
In recent years, diverse nanoemulsion vehicles (NEs) have been developed with vast potential for improving therapeutic index of clinically approved and experimental drugs. Using oils rich in omega-3 and omega-6 polyunsaturated fatty acids (PUFA), several promising nanoemulsion formulations have been developed recently for oral and systemic administration. The aim of ...
Borkowska M - - 2012
The polymeric permiselective membranes application for immunoisolation of cells separating the transplanted cells from the host immunological system may eliminate immunosuppressive therapy during transplantation. The suitability of polyelectrolyte modified nanocoatings for immunoisolation of cells was assessed. The polymeric shells modified with incorporated fullerene derivate were applied for encapsulation of human ...
Koppolu Bhanuprasanth - - 2012
The objective of this work was to develop and investigate temperature-sensitive poly(N-isopropylacrylamide-acrylamide-allylamine)-coated iron oxide magnetic nanoparticles (TPMNPs) as possible targeted drug carriers for treatments of advanced thyroid cancer (ATC). These nanoparticles were prepared by free radical polymerization of monomers on the surface of silane-coupled iron oxide nanoparticles. In vitro studies ...
Liu Bin - - 2012
With the wide application of nanomaterials in biomedical detection in recent years, hybridization methods which use nanoparticles as solid phase hybridization carriers have emerged. However, commercial equipments, such as conventional thermal cyclers and hybridization ovens are usually not appropriate for DNA hybridization on the surface of nanoparticles. We designed and ...
Hekmat Azadeh - - 2012
The structural changes in DNA caused by the combined effects of silver nanoparticles (Ag NPs) and doxorubicin (DOX) was investigated along with their corresponding inhibitory roles in the growth of T47D and MCF7 cells. The UV-visible titration studies showed that DOX + AgNPs could form a novel complex with DNA ...
Prabhu Priyanka - - 2012
Nanocarriers have drastically changed the face of health care by making a mark in diverse arenas of diagnosis, drug delivery, and gene delivery to name a few. The recent feat in nanotechnology has been the birth of nanotheranostics which aims at blending both therapeutic and diagnostic functions within a single ...
Lalani Jigar - - 2012
Receptor mediated endocytosis or transcytosis has been reported for drug delivery across Blood-brain barrier (BBB) and hence, the aim of the present investigations was to prepare and compare brain targeting efficiency of tramadol-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles surface modified with transferrin (Tf) and lactoferrin (Lf). Nanoparticles of tramadol were prepared ...
Ma Chao - - 2012
In this article, we present an easy route to prepare monodisperse core-shell Fe3O4@SiO2 microspheres with uniform size and shape. Their structures and properties were studied by transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectrometry (FT-IR), and vibrating sample magnetometer (VSM), respectively. The results showed that spherical ...
Gurzawska Katarzyna - - 2012
Long-term stability of titanium implants are dependent on a variety of factors. Nanocoating with organic molecules is one of the method used to improve osseointegration. Nanoscale modification of titanium implants affects surface properties, such as hydrophilicity, biochemical bonding capacity and roughness. This influences cell behaviour on the surface such as ...
Kumar P T Sudheesh - - 2012
We developed chitin hydrogel/nano ZnO composite bandages using chitin hydrogel and ZnO nanoparticles (nZnO). The homogenized mixture of chitin hydrogel and nZnO was freeze-dried to obtain micro-porous composite bandages. The prepared nanocomposite bandages were characterized using FT-IR, XRD and SEM. In addition, blood clotting, antibacterial, swelling, cytocompatibility and cell attachment ...
Sundvik Maria - - 2012
Histamine is an essential factor in the ascending arousal system (AAS) during motivated behaviors. Histamine and hypocretin/orexin (hcrt) are proposed to be responsible for different aspects of arousal and wakefulness, histamine mainly for cognitive and motivated behaviors. In this study we visualized the entire histaminergic neuron population in adult male ...
Paszek Elzbieta - - 2012
Disruption of the intercellular interactions between endothelial cells leads to endothelial dysfunction. The role of nanoparticles in plasma membrane stability, actin cytoskeleton organization and intercellular junctions is unclear. Human umbilical vein endothelial cells were treated with zinc oxide NPs in vitro. Cell shape, adhesiveness and plasma membrane integrity were analyzed ...
Xu Lijian - - 2012
Fabrication of three different electrodes based on functional porous pseudo-carbon paste electrodes (PPCPEs) was described. PPCPEs were modified with carboxylic multi-walled carbon nanotubes (PPCPE-COOH), glutaraldehyde (PPCPE-CHO) and 3-aminopropyltriethoxysilane (PPCPE-NH2). The modified electrodes were applied in detection of E. coli O157:H7, it was showed that the electrochemical signal of PPCPE-CHO was ...
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