Search Results
Results 351 - 400 of 3178
< 3 4 5 6 7 8 9 10 11 12 13 >
Echard Arnaud - - 2012
The ESCRT (endosomal sorting complex required for transport) machinery is responsible for scission of the cytokinetic bridge that connects daughter cells at the end of mitosis. Specific endosomes are now found to mediate local bridge constriction and actin clearance in human cells, which contribute to the recruitment of ESCRT components ...
Wiƛniowiecka-Kowalnik Barbara B Department of Medical Genetics, Institute of Mother and Child, Warsaw, - - 2013
Autism spectrum disorders (ASDs) are a heterogeneous group of neurodevelopmental disorders, including childhood autism, atypical autism, and Asperger syndrome, with an estimated prevalence of 1.0-2.5% in the general population. ASDs have a complex multifactorial etiology, with genetic causes being recognized in only 10-20% of cases. Recently, copy-number variants (CNVs) have ...
Chen G-C - - 2012
Epidemiologic studies have suggested that magnesium intake may be associated with a decreased risk of colorectal cancer (CRC), but the findings have been inconsistent. We aimed to assess this association by conducting a meta-analysis of prospective studies. We performed a literature search on PubMed database through July 2012 to identify ...
de Almeida Natália E C - - 2012
Lupulones, hops β-acids, are one of the main constituents of the hops resin and have an important contribution to the overall bacteriostatic activity of hops during beer brewing. The use of lupulones as natural alternatives to antibiotics is increasing in the food industry and also in the bio-ethanol production. However, ...
Patsoukis Nikolaos N Division of Hematology-Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA - - 2012
The programmed cell death-1 (PD)-1 receptor (CD279) is a potent T cell inhibitor with a critical role in peripheral tolerance, but it can also compromise anti-viral and antitumor T cell responses. The effects of PD-1 on the cell cycle leading to inhibition of T cell expansion are poorly understood. Recently, ...
Abbès Samir - - 2012
Aflatoxin M(1) (AFM(1)) has been detected in many parts of the world both in raw milk and many dairy products, causing great economic losses and human disease. Unfortunately, there are few studies dealing with AFM(1) immunotoxicity/interactions with lactic acid bacteria for potential application as a natural preventive agent. The aim ...
Winter Heidi - - 2012
ABSTRACT Background: Globally, falls in older people are a leading cause of injury-related mortality and morbidity. Cognitive impairment is a well-known risk factor for falls in this population group. While there is now a large body of evidence to support effective interventions for falls reduction across care settings, very little ...
Johnson Bryce E - - 2012
Effective collection of trace-level lanthanides and actinides is advantageous for recovery and recycling of valuable resources, environmental remediation, chemical separations, and in situ monitoring. Using isotopic tracers, we have evaluated a number of conventional and nanoporous sorbent materials for their ability to capture and remove selected lanthanides (Ce and Eu) ...
Dreher Thomas - - 2012
The evidence for distal rectus femoris transfer as a part of multilevel surgery for the correction of stiff-knee gait in children with spastic diplegic cerebral palsy is limited because of inconsistent outcomes reported in various studies and the lack of long-term evaluations. This study investigated the long-term results (mean, nine ...
Jung Sang Taek - - 2012
Glycans anchored to residue N297 of the antibody IgG Fc domain are critical in mediating binding towards FcγRs to direct both adaptive and innate immune responses. However, using a full length bacterial IgG display system, we have isolated aglycosylated Fc domains with mutations that confer up to a 160-fold increase ...
Okami Nobuya N Department of Neurosurgery, Department of Neurology and Neurological Sciences, and Program in Neurosciences, Stanford University School of Medicine, Stanford, CA, - - 2013
Rosiglitazone, a synthetic peroxisome proliferator-activated receptor-γ (PPARγ) agonist, prevents cell death after cerebral ischemia in animal models, but the underlying mechanism has not been clarified. In this study, we examined how rosiglitazone protects neurons against ischemia. Mice treated with rosiglitazone were subjected to 60 minutes of focal ischemia followed by ...
Zhang Qiao - - 2012
In this viewpoint we discuss the early work of Murphy et al. on the colloidal synthesis of silver nanorods and nanowires, which represents a milestone in the controllable synthesis of anisotropic metal nanoparticles. We present here an overview of the impact of this pioneering work on the later drastic development ...
Sass Katharina - - 2012
In depression, patients suffer from emotional and cognitive deficits, among others in semantic processing. If these semantic deficits are cognitive or interact with emotional dysfunctions, is still an open question. The aim of the current study was to investigate the influence of emotional valence on the neural correlates of semantic ...
Sharma Prabodh Chander - - 2012
Heterocycles bearing nitrogen, sulphur and thiazole moieties constitute the core structure of a number of biologically interesting compounds. Benzothiazole, a group of xenobiotic compounds containing a benzene ring fused with a thiazole ring, are used worldwide for a variety of therapeutic applications. Benzothiazole and their heterocyclic derivatives represent an important ...
Noel S E SE Department of Pediatrics, Boston University School of Medicine, Boston Medical Center, Boston, MA, - - 2013
Few studies have investigated the associations between flavored milk consumption and body composition in children. We aimed to examine the prospective relationships between flavored milk consumption and body fat. Subjects included 2270 children from the Avon Longitudinal Study of Parents and Children. Flavored milk consumption at age 10 years was ...
Chen Jing - - 2012
Radon and its decay products have been identified as the second leading cause of lung cancer after tobacco smoking. Thoron is an isotope of radon. With increased awareness of radon, questions related to thoron are arising from the public. Currently, only radon detectors are commonly available to Canadian homeowners. A ...
Pastore Antonio Luigi - - 2012
Abstract Purpose: Transurethral resection of prostate (TURP) still represents the gold standard in the surgical treatment of symptomatic benign prostatic hyperplasia (BPH). The most frequent complication is represented by intra- and perioperative bleeding. Preoperative use of 5-alpha-reductase inhibitors (finasteride or dutasteride) to reduce surgical bleeding is still a topic of ...
Van der Veldt Astrid A M AA Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands. - - 2012
Many cancer patients are treated with a combination of anticancer drugs. Here, we discuss the importance of drug scheduling and the need for studies that investigate the optimal timing of the various anticancer drugs. Positron emission tomography (PET) using radiolabeled anticancer drugs could be an important tool for those studies.
Veldhuis Sjoerd A - - 2012
Surface areas of typically 5x5 mm2 were patterned with high aspect ratio micron- and submicron-sized structures of yttria-stabilized zirconia using a combination of micromolding in capillaries and sol-gel chemistry. The influence of precursor solution concentration and mold geometry on the final shape and dimensions of the patterned structures was investigated. ...
Longhi S - - 2012
In the framework of the Hubbard model, it is shown that approximate dynamic localization for strongly correlated electrons hopping on a one-dimensional lattice and driven by a high-frequency sinusoidal field can be realized provided that periodic π phase slips are impressed into the sinusoidal field. A possible experimental demonstration of ...
Nie J - - 2012
Skin homeostasis is maintained by controlling the balance between proliferation and differentiation of epidermal stem cells. The microenvironment, including extrinsic stresses, growth factors, soluble molecules, cell-ECM and cell-cell communications, plays an important role in cell fate determination in vivo and in vitro. In response to external signals, keratinocytes cooperate with ...
Chen De-Li - - 2012
Adsorption of noble gases on metal surfaces is determined by weak interactions. We applied two versions of the nonlocal van der Waals density functional (vdW-DF) to compute adsorption energies of Ar, Kr, and Xe on Pt(111), Pd(111), Cu(111), and Cu(110) metal surfaces. We compared our results with data obtained using ...
Abay Simon - - 2012
We report on fabrication of InAs nanowires coupled to superconducting leads with high critical current and widely tunable conductance. We implemented a double lift-off nanofabrication method to get very short nanowire devices with Ohmic contacts. We observe very high critical currents of up to 800nA in a wire with a ...
Skelley Nathan W - - 2012
Since the 1910 Flexner Report, medical education continues to undergo curriculum and graduation guideline reform to meet the needs of physicians and patients. Our aims were to (1) assess the quality of musculoskeletal education at our institution's School of Medicine by reporting the results of the Freedman and Bernstein examination ...
Hanke Felix - - 2012
We have investigated the performance of popular density functionals that include van der Waals interactions for the experimentally well-characterized problem of ethene (C(2)H(4)) adsorbed on the low-index surfaces of copper. This set of functionals does not only include three van der Waals density functionals-vdwDF-PBE, vdwDF-revPBE and optB86b-vdwDF-and two dispersion-corrected functionals-Grimme and TS-but ...
Hahm Myung Gwan - - 2012
Here, we design and develop high-power electric double-layer capacitors (EDLC) using carbon based dimensional (3D) hybrid nanostructured electrodes. 3D hybrid nanostructured electrodes consist of vertically aligned carbon nanotubes (CNT) on highly porous carbon nanocups (CNC) were synthesized by combination of anodization and chemical vapor deposition techniques. 3D electrode based supercapacitor ...
Pereira Raquel - - 2012
A SAR study has been carried out around the modified scaffold of the psammaplin A natural product obtained replacing the o-bromophenol unit by an indole ring. A series of indole-psammaplin A constructs were generated in a short synthetic sequence that attachs the oximinoamide chain to the corresponding C3 indole position. ...
Longo Stefania - - 2012
Intrauterine Growth Retardation (IUGR) is defined as a rate of growth of a fetus that is less than normal for the growth potential of the fetus (for that particular gestational age). Small for Gestational Age (SGA) is defined infant born following IUGR, with a weight at birth below the 10th ...
Keeve P L - - 2012
BACKGROUND AND OBJECTIVE: Stem cells derived from periodontal and palatal tissues may be useful for regenerative therapies of periodontal tissues. In addition to the use of single periodontium-derived stem cells (pdSCs) and palatal-derived stem cells (paldSCs), the application of pdSC and paldSC dentospheres, providing a pool of vital stem cells, ...
Liaugaudas G - - 2012
The decay time of luminescence from neutral nitrogen-vacancy (NV (0)) centres in synthetic diamond is reported. The intrinsic luminescence lifetime of NV (0) is measured as τ(r) = 19 ± 2 ns. Neutral substitutional nitrogen atoms [Formula: see text] are shown to quench luminescence from NV(0) by dipole-dipole resonant energy transfer at a rate such ...
Sanjaya Stephen - - 2012
A Cu-catalyzed aminoacetoxylation of N-alkenylamidines has been achieved using PhI(OAc)(2) as an oxygen source for synthesis of 4-acetoxymethyl-4,5-dihydroimidazoles, which could be further converted into 2,3-diaminopropanol derivatives using AlH(3) as a reductant.
Zhang K H L - - 2012
The growth of Bi on Ag(111) induces different surface structures, including [Formula: see text] surface alloy, Bi-[Formula: see text] overlayer and Bi(110) thin film, as a function of increasing Bi coverage. Here we report the study of electronic states of these structures using core level and valence band photoemission spectroscopy ...
Griaud F F Stem Cell and Leukaemia Proteomics Laboratory, Manchester Academic Health Science Centre, The University of Manchester, Wolfson Molecular Imaging Centre, Withington, Manchester, - - 2013
THOC5 is a member of the THO complex that is involved in processing and transport of mRNA. We have shown previously that hematopoietic stem cells have an absolute requirement for THOC5 for survival and that THOC5 is phosphorylated on tyrosine 225 as a consequence of leukemogenic protein tyrosine kinase (PTK) ...
Konarev Dmitri V DV Institute of Problems of Chemical Physics RAS, Chernogolovka, Moscow region, Russia. - - 2012
Ionic compounds containing the anion of iron phthalocyanine (Fe(I)Pc)(-), {(Fe(I)Pc)(-)}·(cryptand[2,2,2]·[Na(+)])·(C(6)H(4)Cl(2)) (1), and the fullerene C(70)(-) and Fe(I)Pc(-) anions, (C(70)(-))(2)·{(Fe(I)Pc)(-)}(6)·(cryptand[2,2,2]·[Na(+)])(8)·(C(6)H(4)Cl(2))(8.65)·(C(6)H(14))(0.35) (2), were obtained as single crystals. Their crystal structures and optical and magnetic properties were analyzed. Spectra of 1 and 2 manifest intense bands in visible-NIR range at 820, 690, 555, ...
Aullón Gabriel - - 2012
To date, crystal structures of the cyclic mercury complexes [μ-1,2-(C(2)B(10)H(10))(n)Hg(n)], with n = {3, 4}, have been found. However, the same structures substituting Hg by Au, which implies a charge z = {-3, -4} for n = {3, 4} respectively, have not been found. In this work, we present geometrical ...
Husemoen L L N - - 2012
BACKGROUND/OBJECTIVES:Mild to moderate vitamin D insufficiency has been proposed as a risk factor for several common chronic diseases including type 2 diabetes. This study aimed to examine the association between serum 25-hydroxy vitamin D (25(OH)D) and incident diabetes.SUBJECTS/METHODS:The MONICA10 cohort consists of 2656 participants (men and women aged 41-71 years) ...
Turygin Nicole - - 2012
Objective: To determine the effect of the changing fifth edition of the Diagnostic and Statistical Manual (DSM-5) criteria on the developmental profiles of children diagnosed with an Autism spectrum disorder (ASD). Methods: This study examines the effect of DSM-5 changes on impairment profiles of a population of 2054 at-risk toddlers ...
Perdew John P - - 2012
Fullerene molecules such as C(60) are large nearly spherical shells of carbon atoms. Pairs of such molecules have a strong long-range van der Waals attraction that can produce scattering or binding into molecular crystals. A simplified classical-electrodynamics model for a fullerene is a spherical metal shell, with uniform electron density ...
Miwa Takashi - - 2012
This study was designed to evaluate two pen needles (PNs) with the same diameter but different lengths (4 mm and 6 mm) and different needle tip shapes (straight and tapered) to compare their effects on glycemic control, perceived pain, safety, patients' ease of use and preferences, and visual impression. In ...
Winkels Diny G M - - 2012
Objective: Commercially available virtual reality systems can possibly support rehabilitation objectives in training upper arm function in children with Cerebral Palsy (CP). The present study explored the effect of the Nintendo Wii™ training on upper extremity function in children with CP. Methods: During six weeks, all children received twice a ...
Fujii Yukiko - - 2012
A gas chromatography-mass spectrometry and electron-capture negative ionization (ECNI) method was developed to quantify perfluorinated carboxylic acids (PFCAs) in composite dietary samples. Benzyl esterification was used for pretreatment before PFCAs analysis. This stabilized the benzyl radical leaving group preferentially, and gave carboxylic anions of the PFCAs with ECNI. The method ...
Baverel Gabriel - - 2012
1. Unlike cell lines and primary cells in culture, precision-cut tissue slices remain metabolically differentiated for at least 24-48 h and allow to study the effect of xenobiotics during short-term and long-term incubations. 2. In this article, we illustrate the use of such an experimental model to study the nephrotoxic effects of (i) ...
Ganagona N - - 2012
The formation of the divacancy-oxygen centre (V(2)O) in p-type Czochralski-grown silicon has been investigated by means of deep level transient spectroscopy (DLTS). The donor state (+/0) of V(2)O is located at ∼E(v) + 0.23 eV (E(v) denotes the valence band edge) and emerges during heat treatment above 200 °C at the expense of the ...
Schacht Joseph P JP Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA. - - 2013
Variation at a single nucleotide polymorphism in the μ-opioid receptor gene (OPRM1), A118G (Asn40Asp), may moderate naltrexone (NTX) effects in alcohol dependence. Both NTX and A118G variation have also been reported to affect alcohol cue-elicited brain activation. This study investigated whether sub-acute NTX treatment and A118G genotype interacted in their ...
Haqq-Misra Jacob - - 2012
Abstract Proposals to address present-day global warming through the large-scale application of technology to the climate system, known as geoengineering, raise questions of environmental ethics relevant to the broader issue of planetary engineering. These questions have also arisen in the scientific literature as discussions of how to terraform a planet ...
Larsen Martin M - - 2012
Analyses of lead (Pb) isotopes have been performed in terrestrial and fresh water environments to estimate historical uses of leaded fuel, but so far this method has not been employed in studies of world-wide marine surface sediments. We analyzed Pb and its isotopes in 23 surface sediments from four continents ...
Li Q - - 2012
The hydrogen-methane compound (H(2))(4)CH(4)-or for short H4M-is one of the most promising hydrogen-storage materials. This van der Waals compound is extremely rich in molecular hydrogen: 33.3 mass%, not including the hydrogen bound in CH(4); including it, we reach even 50.2 mass%. Unfortunately, H4M is not stable under ambient pressure and temperature, requiring ...
Yang Hui-Yu - - 2012
Angiotensin-(1-7) (Ang-(1-7)), a metabolite of angiotensin I and angiotensin II (Ang II), is a counterregulatory mediator of Ang II. Here, we investigated the effects of Ang-(1-7) on Ang II-induced apoptosis in human umbilical vein endothelial cells (HUVECs). Acridine orange/ethidium bromide (AO/EB) staining and propidium iodide (PI) staining were used to ...
Huple Deepak B - - 2012
We report a gold-catalyzed [2+2+2]-cycloaddition of 1,7-enynes with carbonyl species; our experimental data suggest that the resulting oxacyclic cycloadducts arose from an interception of gold-containing cyclobutenium intermediates with carbonyl species.
Karmakar Debjani - - 2012
Interesting magnetic properties and spin-exchange interactions along various possible pathways in the half-integral spin quantum magnetic tetramer system: A(2)PO(4)OH (A=Co, Cu) are investigated. Interplay of structural distortion and the magnetic properties with the evolution of localized band structure explain the gradual transition from a three-dimensional antiferromagnet to a low-dimensional frustrated ...
< 3 4 5 6 7 8 9 10 11 12 13 >