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Results 301 - 350 of 3179
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Holt Graeme - - 2012
Hip fracture is a common cause of morbidity and mortality in the elderly. As the risk factors for hip fracture often persist after the original injury, patients remain at risk for sequential fractures. Our aim was to report the incidence, epidemiology, and outcome of sequential hip fracture in the elderly. ...
Helliwell Emily E - - 2012
Rice blast (Magnaporthe oryzae) and sheath blight (Rhizoctonia solani) are the two most devastating diseases of rice (Oryza sativa), and have severe impacts on crop yield and grain quality. Recent evidence suggests that ethylene (ET) may play a more prominent role than salicylic acid and jasmonic acid in mediating rice ...
Salazar Ramon - - 2012
This article provides experimental evidence of one-dimensional (1D) behavior of silicon (Si) nanowires (NWs) at low-temperature through both, transfer (Id-VG) and capacitance-voltage (CV) characteristics. For the first time, operation of Si NWs in the quantum capacitance limit (QCL) is experimentally demonstrated and quantitatively analyzed. This is of relevance since working ...
Sitek Arkadiusz - - 2012
A novel approach to the analysis of emission tomography data using the posterior probability of the number of emissions per voxel (emission count) conditioned on acquired tomographic data is explored. The posterior is derived from the prior and the Poisson likelihood of the emission-count data by marginalizing voxel activities. Based ...
di Poggio Monica Bandettini - - 2012
Abstract Our objective was to assess the incidence and trends of amyotrophic lateral sclerosis (ALS) in Liguria, a north-west region of Italy, utilizing a prospective design. Liguria (1,615,064 residents in 2010) is the site of a multicentre-multisource prospective population based registry called LIGALS (Liguria Amyotrophic Lateral Sclerosis Registry). All incident ...
Barnard Anna - - 2012
The ability of self-assembling multivalent DNA-binding dendrons to interact with biological targets is modified by co-assembly with two novel low-molecular-weight cholesterol-functionalised PEG units, one based on triethylene glycol (Chol-PEG-3) and one on an octaethylene glycol (Chol-PEG-8). The addition of either PEG lipid affected the co-assembled nanostructure surface charge and size ...
Sabatini Riccardo - - 2012
Use of the non-local correlation functional vdW-DF (from 'van der Waals density functional'; Dion M et al 2004 Phys. Rev. Lett. 92 246401) has become a popular approach for including van der Waals interactions within density functional theory. In this work, we extend the vdW-DF theory and derive the corresponding stress tensor in a ...
Beaumont Steven P - - 2012
AIMS AND OBJECTIVES: To explore how peacetime employment of military nurses in the UK National Health Service Medical Defence Hospital Units prepares them to be competent to practise in their role on deployment. BACKGROUND: Military secondary care nurses are employed within UK National Health Service Trusts to gain clinical experience ...
White J S - - 2012
Small-angle neutron scattering has been employed to study the influence of applied electric (E-)fields on the skyrmion lattice in the chiral lattice magnetoelectric Cu(2)OSeO(3). Using an experimental geometry with the E-field parallel to the [111] axis, and the magnetic field parallel to the [[Formula: see text]] axis, we demonstrate that ...
Zhan Yong - - 2012
We have synthesized new D-A-D type phosphorus(v) porphyrin derivatives and functionalized with axial carbazolylvinylnaphthalimide units. The absorption bands of the obtained phosphorus(v) porphyrins were in the range 250-640 nm with high molar absorption coefficients, meaning strong light-harvesting abilities. Notably, it is found that the devices based on phosphorus(v) porphyrins with ...
Huple Deepak B - - 2012
We report a gold-catalyzed [2+2+2]-cycloaddition of 1,7-enynes with carbonyl species; our experimental data suggest that the resulting oxacyclic cycloadducts arose from an interception of gold-containing cyclobutenium intermediates with carbonyl species.
Karmakar Debjani - - 2012
Interesting magnetic properties and spin-exchange interactions along various possible pathways in the half-integral spin quantum magnetic tetramer system: A(2)PO(4)OH (A=Co, Cu) are investigated. Interplay of structural distortion and the magnetic properties with the evolution of localized band structure explain the gradual transition from a three-dimensional antiferromagnet to a low-dimensional frustrated ...
Luo Feng - - 2012
A distinct way to target long-lasting phosphors (LLPs) is disclosed. This new material is a metal-organic framework featuring a 1D zig-zag chain and 3D hydrogen bonded PtS net with three-fold interpenetration. It exhibits persistent luminescence lasting about 1 s which can be traced by the naked eye. The green persistent ...
Harbison Christopher T - - 2012
Context.- The therascreen KRAS RGQ PCR kit is being developed as a companion diagnostic to aid clinicians, through detection of KRAS mutations, in the identification of patients with metastatic colorectal cancer (mCRC) who are more likely to benefit from cetuximab. Objective.- To assess whetherKRASmutation status, determined by using the therascreen ...
Ciupa Alexander - - 2012
An efficient two-step synthesis of pyrazoline ligand is described which is an effective "turn on" fluorescent sensor for Cd(2+) in MeCN. Oxidation to the corresponding pyrazole ligand creates a "turn on" fluorescent sensor now selective for Zn(2+) and able to distinguish it from Cd(2+).
Wang Ruhung - - 2012
Abstract Poloxamers (known by the trade name Pluronic(®)) are triblock copolymer surfactants that contain two polyethylene glycol blocks and one polypropylene glycol block of various sizes. Poloxamers are widely used as nanoparticle dispersants for nanotoxicity studies wherein nanoparticles are sonicated with a dispersant to prepare suspensions. It is known that ...
Koenig Thomas - - 2012
Spectroscopic x-ray imaging by means of photon counting detectors has received growing interest during the past years. Critical to the image quality of such devices is their pixel pitch and the sensor material employed. This paper describes the imaging properties of Medipix2 MXR multi-chip assemblies bump bonded to 1 mm thick ...
Congyu Ke - - 2012
An approach for re-folding denatured proteins during proteome research by protein folding liquid chromatography (PFLC) is presented. Standard protein, α-chymotrypsin (α-Chy), was selected as a model protein and hydrophobic interaction chromatography was performed as a typical PFLC; the three different α-Chy states - urea-denatured (U state), its folded intermediates (M ...
Barford William - - 2012
We present a first principles theory of exciton diffusion in conformationally disordered conjugated polymers. Central to our theory is that exciton transfer occurs from vibrationally relaxed states (VRS) to local exciton ground states (LEGS). LEGSs are determined by the diagonal and off-diagonal disorder induced by density and torsional fluctuations, while ...
Dreher Thomas - - 2012
The evidence for distal rectus femoris transfer as a part of multilevel surgery for the correction of stiff-knee gait in children with spastic diplegic cerebral palsy is limited because of inconsistent outcomes reported in various studies and the lack of long-term evaluations. This study investigated the long-term results (mean, nine ...
Jung Sang Taek - - 2012
Glycans anchored to residue N297 of the antibody IgG Fc domain are critical in mediating binding towards FcγRs to direct both adaptive and innate immune responses. However, using a full length bacterial IgG display system, we have isolated aglycosylated Fc domains with mutations that confer up to a 160-fold increase ...
Zhang Qiao - - 2012
In this viewpoint we discuss the early work of Murphy et al. on the colloidal synthesis of silver nanorods and nanowires, which represents a milestone in the controllable synthesis of anisotropic metal nanoparticles. We present here an overview of the impact of this pioneering work on the later drastic development ...
Sass Katharina - - 2012
In depression, patients suffer from emotional and cognitive deficits, among others in semantic processing. If these semantic deficits are cognitive or interact with emotional dysfunctions, is still an open question. The aim of the current study was to investigate the influence of emotional valence on the neural correlates of semantic ...
Wang Steven Q - - 2012
Excessive exposure from ultraviolet (UV) radiation contributes to the development of skin cancers and photoaging. Topical sunscreen products remain one of the most widely used forms of protection for the majority of the public. The objective of this analysis was to examine photoprotection trends (e.g., SPF value) and the degree ...
Yasui Takao - - 2012
We demonstrated DNA droplets could be injected with an inkjet injector for microchannel array electrophoresis and attained high throughput analysis of biomolecules. This injection method greatly reduced both analysis time and sample amount, compared with a conventional microchip electrophoresis method, and allowed high parallelization of a microchannel array on a ...
Calvo Begoña - - 2012
In the US, the Biologics Price Competition and Innovation Act (BPCI Act, 2009) provided the pathway to create an abbreviated licensure procedure for biologic products that are demonstrated to be biosimilar to or interchangeable with a Food and Drug Administration (FDA) licensed biologic product. In February 2012, the FDA issued ...
Dong H - - 2012
As the Bacillus Calmette-Guérin (BCG) vaccine does not confer long-lasting protection against lung Mycobacterium tuberculosis infection, the development of more efficient vaccines is greatly needed. Here, we used mycobacterial low-molecular weight proteins of the 6-kDa Early Secreted Antigenic Target (ESAT-6) protein family (ESX) antigens for the evaluation of a novel ...
Roy Subhadeep - - 2012
Oligodeoxyribonucleotides bearing boranephosphonate linkages (bpDNA) were shown to reduce a number of metal ions and form nanoparticles through a novel reaction pathway that leads to phosphate diesters or phosphate triesters in water or alcohols respectively. The synthetic utility of this reaction was further demonstrated through the synthesis of oligodeoxyribonucleotides containing ...
Wilson James N - - 2012
We report the synthesis, binding kinetics, optical spectroscopy and predicted binding modes of a series of sterically demanding, fluorescent norepinephrine transporter (NET) ligands. A series of bulky stilbazolium dyes, including six newly synthesized compounds, were evaluated to determine the effect of extending the molecular probes' 'heads' or 'tails'. Taking advantage ...
Bai Lijuan - - 2012
For the first time, a glucose oxidase-functionalized bioconjugate was prepared and served as a new trace label through its direct electrochemistry and electrocatalysis in a sandwich-type electrochemical aptasensor for ultrasensitive detection of thrombin.
Wright Kevin B - - 2012
This study examined the influence of the social networking site Facebook and face-to-face support networks on depression among (N = 361) college students. The authors used the Relational Health Communication Competence Model as a framework for examining the influence of communication competence on social support network satisfaction and depression. Moreover, they examined ...
Zhang Hongyang - - 2012
The aim of this study was to investigate the cellular lipid metabolism associated with β-amyloid peptide (Aβ)-induced neurotoxicity as well as the neuroprotective effect of (-)-epigallocatechin gallate (EGCG), a major polyphenol in green tea. An ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS)-based lipidomic approach was developed to screen and identify changes ...
Giorgio V - - 2012
Background  Severe pediatric slow transit constipation (STC) is commonly due to intrinsic colonic neuromuscular disease. We sought to correlate neuromuscular histological phenotypes in pediatric STC with colonic manometric phenotypes using high-resolution manometry (HRM). We tested the hypothesis that failure of motor quiescence (FQ) between bisacodyl-induced high amplitude propagating sequences (HAPSs) ...
Souka Athena P - - 2012
OBJECTIVE: This study aims to investigate the intra-observer and inter-observer variability of crown-rump length (CRL) and biparietal diameter (BPD) measurements in the first trimester. METHODS: A prospective observational study on 592 fetuses between 8 and 14 gestational weeks was conducted. Intra-class correlation coefficients (ICCs) were computed, and Bland-Altman analysis was ...
Klimchitskaya G L - - 2012
We propose a new experiment on the measurement of the Casimir force and its gradient between a Au-coated sphere and two different plates made of doped semiconductors. The concentrations of charge carriers in the plates are chosen slightly below and above the critical density at which the Mott-Anderson insulator-metal transition ...
Spice Andrew - - 2012
Literature on risk factors for recidivism among juveniles who have sexually offended (JSOs) is limited. In addition, there have been no studies published concerning protective factors among this population. The purpose of this study was to examine the relationship of risk and protective factors to sexual and nonsexual recidivism among ...
Eigemann Falk - - 2012
We studied bacterial associations with the green alga Desmodesmus armatus and the diatom Stephanodiscus minutulus under changing environmental conditions and bacterial source communities, to evaluate whether bacteria-algae associations are species-specific or more generalized, and determined by external factors. Axenic and xenic algae were incubated in situ with and without allelopathically-active ...
Farshad Mazda - - 2012
Subacromial injection of a local anesthetic is used to eliminate pain as a confounding factor in clinical assessment of abduction strength in shoulders with a suspected rotator cuff tear. If strength remains diminished despite pain relief, a rotator cuff tear is likely. The effect of injecting local anesthetic into the ...
Xun P - - 2012
BACKGROUND/OBJECTIVES:To provide a reliable assessment of the hypothesized association of fish consumption with stroke risk accumulatively, an updated meta-analysis of published prospective cohort studies was conducted.SUBJECTS/METHODS:Prospective cohort studies through April 2012 in peer-reviewed journals indexed in MEDLINE and EMBASE were selected. Additional information was retrieved through Google or a search ...
Xu Hong-Yi - - 2012
In this study, we report the epitaxial growth of defect-free zinc-blende structured InAs nanowires on GaAs{111}B substrates using palladium catalysts in a metal-organic chemical vapor deposition reactor. Through detailed morphological, structural and chemical characterizations using electron microscopy, it is found that these defect-free InAs nanowires grew along the 〈1 ̅1 ...
Kadambi Ananth - - 2012
Economic models are developed to provide decision makers with information related to the real-world effectiveness of therapeutics, screening and diagnostic regimens. Although compliance with these regimens often has a significant impact on real-world clinical outcomes and costs, compliance and persistence have historically been addressed in a relatively superficial fashion in ...
Jackson S C - - 2012
Disorders of collagen are associated with a mild bleeding tendency because of the potential abnormal interaction of collagen, von Willebrand factor (VWF) and platelets required during primary haemostasis and due to generalized soft tissue fragility. Abnormal collagen may contribute to bleeding in existing mucocutaneous bleeding disorders, but the prevalence in ...
Jeon Ji-Young - - 2012
Candesartan is a long-acting and selective nonpeptide AT(1) subtype angiotensin II receptor antagonist. The aim of this study was to compare the pharmacokinetics and to evaluate the bioequivalence of two candesartan cilexetil 16 mg formulations. Forty healthy volunteers were randomly assigned into two groups. After a single dose of 16 mg candesartan ...
Guo Xugang - - 2012
Abstract. Rational creation of polymeric semiconductors from novel building blocks is critical to the polymer solar cell (PSC) development. We report a new series of bithiopheneimide-based donor-acceptor copolymers for bulk-heterojunction (BHJ) PSCs. The bithiopheneimide electron-deficiency compresses polymer bandgaps and lowers the HOMOs--essential to maximize power conversion efficiency (PCE). While the ...
Fisher Robyn L - - 2012
1. Human and animal precision-cut organ slices are being widely used to obtain drug metabolism and toxicity profiles in vitro. These data are then used to predict what might be seen in human patients. The accuracy of this prediction and extrapolation of the findings based on human or animal in vitro ...
Rodda Joanne - - 2012
ABSTRACT Background: Mild cognitive impairment (MCI) may represent a transitional stage between normal functioning and dementia. Following the initial criteria developed by Petersen et al. in 1999, which focused on memory deficit in the context of otherwise normal cognition and general functioning, the concept has evolved with the introduction of ...
Hermann M - - 2012
Classical non-steroidal anti-inflammatory drugs (NSAID) and new selective inhibitors of cyclooxygenase-2(Cox-2 inhibitors) have been successfully used for several decades in the treatment of patients with chronic pain. In addition of their well known adverse gastrointestinal effects, these drugs have been recognized during recent years to increase cardiovascular risk. This risk ...
Suhre Karsten - - 2012
Many complex disorders are linked to metabolic phenotypes. Revealing genetic influences on metabolic phenotypes is key to a systems-wide understanding of their interactions with environmental and lifestyle factors in their aetiology, and we can now explore the genetics of large panels of metabolic traits by coupling genome-wide association studies and ...
Baadkar Shruti V - - 2012
Background: Lactase nonpersistence (LNP) is characterized by the decrease in lactase expression in the small intestine. Studies have shown that -13910 C>T and -22018 G>A single-nucleotide polymorphisms (SNPs) located upstream of the lactase gene are associated with an LNP/lactase persistence (LP) trait. Objective: The current study evaluated the LP allelic ...
Lee Jong Hee - - 2012
Abstract Background and Objective: This study evaluated clinical usefulness of long-pulsed Nd:YAG laser (LPNY) for periorbital wrinkles in Asian patients. Methods: Twenty seven Korean patients were treated with several passes of LPNY (5mm spot size, fluence:54.7-61.8 J/cm2, pulse duration: 56.5 microseconds). Three treatment sessions were conducted every two weeks on ...
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