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Xu Lijian - - 2012
Fabrication of three different electrodes based on functional porous pseudo-carbon paste electrodes (PPCPEs) was described. PPCPEs were modified with carboxylic multi-walled carbon nanotubes (PPCPE-COOH), glutaraldehyde (PPCPE-CHO) and 3-aminopropyltriethoxysilane (PPCPE-NH2). The modified electrodes were applied in detection of E. coli O157:H7, it was showed that the electrochemical signal of PPCPE-CHO was ...
Sharma Pravin - - 2012
Cytarabine (Cyt) used in the treatment of meningeal leukemia is associated with drawbacks like non selectivity to tumor cells, very short half-life and inability to cross blood brain barrier (BBB) due to its hydrophilic nature. Therefore, stable lipid drug conjugate (LDC) of Cyt with stearic acid was prepared. LDC was ...
Bansch Peter - - 2012
Trauma induces transcapillary leakage of fluid and proteins because of increased microvascular permeability. Based on studies showing that prostacyclin (PGI2) has permeability-reducing properties, in the present study, we investigated whether PGI2 reduces plasma volume (PV) loss after a nonhemorrhagic trauma. The study was performed on anesthetized Sprague-Dawley rats exposed to ...
Koppolu Bhanuprasanth - - 2012
The objective of this work was to develop and investigate temperature-sensitive poly(N-isopropylacrylamide-acrylamide-allylamine)-coated iron oxide magnetic nanoparticles (TPMNPs) as possible targeted drug carriers for treatments of advanced thyroid cancer (ATC). These nanoparticles were prepared by free radical polymerization of monomers on the surface of silane-coupled iron oxide nanoparticles. In vitro studies ...
Lopez Dahianna S - - 2012
Recently, there has been a 58% increase in the number of observed cyclists in San Francisco. In 2009, 3.2% of commuters were traveling by bicycle in this city, which is well above the national average of less than 1%. Police reports are the industry standard for assessing transportation-related collisions and ...
Gurzawska Katarzyna - - 2012
Long-term stability of titanium implants are dependent on a variety of factors. Nanocoating with organic molecules is one of the method used to improve osseointegration. Nanoscale modification of titanium implants affects surface properties, such as hydrophilicity, biochemical bonding capacity and roughness. This influences cell behaviour on the surface such as ...
Kamiyama Masumi - - 2012
Angiotensinogen in the kidneys is formed primarily in the proximal tubule cells and is secreted into the tubular fluid. Structurally, proximal tubules can be divided into three segments. The first segment, segment 1 (S1) is mainly confined to the pars convoluta, the second segment, segment 2 (S2) comprises the end ...
Dougherty Paul J - - 2012
This study is a comparison of the self-reported health status, quality of life, function, and prosthetic use of veterans with bilateral transfemoral limb loss following combat injury in either the Vietnam War or the recent conflicts in Afghanistan and Iraq, to learn what improvements in surgery, prosthetics, and rehabilitation have ...
Jordan Melanie - - 2012
In recent years, diverse nanoemulsion vehicles (NEs) have been developed with vast potential for improving therapeutic index of clinically approved and experimental drugs. Using oils rich in omega-3 and omega-6 polyunsaturated fatty acids (PUFA), several promising nanoemulsion formulations have been developed recently for oral and systemic administration. The aim of ...
Sharpe John P - - 2012
In clinical research, massive transfusion (MT) is commonly defined as transfusion of 10 or more red blood cell (RBC) units within 24 hours. However, the clinical relevance of this definition remains poorly understood. In this study, we evaluated whether patients who reach the MT threshold during hemorrhage control differ clinically ...
Liu Bin - - 2012
With the wide application of nanomaterials in biomedical detection in recent years, hybridization methods which use nanoparticles as solid phase hybridization carriers have emerged. However, commercial equipments, such as conventional thermal cyclers and hybridization ovens are usually not appropriate for DNA hybridization on the surface of nanoparticles. We designed and ...
Kumar P T Sudheesh - - 2012
We developed chitin hydrogel/nano ZnO composite bandages using chitin hydrogel and ZnO nanoparticles (nZnO). The homogenized mixture of chitin hydrogel and nZnO was freeze-dried to obtain micro-porous composite bandages. The prepared nanocomposite bandages were characterized using FT-IR, XRD and SEM. In addition, blood clotting, antibacterial, swelling, cytocompatibility and cell attachment ...
Sundvik Maria - - 2012
Histamine is an essential factor in the ascending arousal system (AAS) during motivated behaviors. Histamine and hypocretin/orexin (hcrt) are proposed to be responsible for different aspects of arousal and wakefulness, histamine mainly for cognitive and motivated behaviors. In this study we visualized the entire histaminergic neuron population in adult male ...
Chen Chen-Chien - - 2012
This study aimed to develop an objective model for predicting mortality after burn injury in Taiwan. From 1997 to 2010, 23,147 patients with acute burn injury in 44 hospitals were retrospectively reviewed. Variables examined were age, sex, depth and extent of burn, inhalation injury, flushing time, hospital admission and referral ...
Morales-Avila Enrique - - 2012
Radiolabelled nanoparticles conjugated to peptides that target specific molecules can be used as agents for diagnosis. For example, technetium-99m-labelled gold nanoparticles conjugated to the cyclic [Arg-Gly-Asp-Phe-Lys(Cys)] (c[RGDfK(C)]) peptide are used for the molecular imaging of tumour-specific alpha(epsilon)beta(3) expression. Gold nanoparticles (AuNPs, 18-20 nm) are assumed to be safe at the ...
Lakshmanan Santana Bala - - 2012
Photothermal therapy (PTT) for cancer treatment is the use of heat between 41 degrees C and 45 degrees C to damage cancer cells. As a new type of transducer agent for PPT of cancer, CuS nanoparticles have several advantages over gold nanostructures. The most favorable features are the low cost, ...
Munro Cynthia A CA Johns Hopkins School of Medicine, Baltimore, MD, USA. - - 2012
Although many depressed patients with Alzheimer disease (AD) are treated with antidepressants, the effect of such treatment on cognitive performance in these patients is not known. The authors report cognitive outcomes in patients with depression of AD (dAD) after a 24-week trial of sertraline or placebo. Placebo-controlled, randomized, double-blind trial. ...
Menon Deepthy - - 2012
Synthesis of biocompatible gold nanoparticles having tunable optical absorbance finds immense use in biomedical applications such as cancer diagnosis and photothermal therapy. Hence, it is imperative to develop environment and bio-friendly green chemical processes that aid in preparing gold nanoparticles with tunable optical properties. In the present work, phytochemicals present ...
Riley Andrew M AM Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, BA2 7AY, - - 2012
We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP(5) mimics 5-PP-InsP(5) binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology ...
Pereyra Florencia F Program in Nutritional Metabolism, Department of Radiology, Massachusetts General Hospital, Boston, - - 2012
HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary atherosclerosis by coronary computed tomography angiography (CTA) in elite controllers, nonelite controller, chronically HIV-1 infected, antiretroviral therapy (ART)-treated patients with undetectable viral load ('chronic HIV'), and HIV-negative controls. Prevalence of atherosclerosis (78 vs. ...
Zhu Manghong M Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430072, - - 2012
Compounds that block estrogen action through the estrogen receptor (ER) or downregulate ER levels are useful for the treatment of breast cancer and endocrine disorders. In our search for structurally novel estrogens having three-dimensional core scaffolds, we found some compounds with a 7-oxabicyclo[2.2.1]heptene core that bound well to the ERs. ...
Zhang Lili L Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, - - 2012
(H(2)O)(32)-shell structure constructed by two unique water molecules in high symmetry crystal leads to good water-solubility of the obtained compound 1.
Power Derek - - 2012
The neuropathology of Huntington's disease includes nuclear and cytoplasmic inclusions, striatal neuronal loss, and gliosis. Previous work put forward a tantalizing proposal that disruption of axonal transport within long, narrow-caliber axons caused accumulations that could elicit cell death, ultimately resulting in neuronal dysfunction. Although a role for the Huntington's disease ...
Zhang Dengwen - - 2012
Previous studies have indicated that estrogen protects the brain from ischemic damage and regulates KATP channel activity; the present study was designed to address the involvement of KATP channels in the neuroprotective effects of estrogen in focal cerebral ischemia: in experiment 1, KATP mRNA and protein in the cortices of ...
Ke Rong-Hu - - 2012
Adenosine A2a receptor (A2aR) is believed to play a role in a number of physiological responses and pathological conditions. Our group has shown previously that A2aR-activated astrocytes occurred following oxygen-glucose deprivation. However, the relationship between A2aR and neurotrophins is poorly understood. Here, we investigate the effect of A2aR on glial ...
Yi Fei - - 2012
Feedback-related negativity (FRN) is an electrophysiological index associated with impulsivity. However, the age and sex effects on FRN are not well understood. Using the single-outcome gambling task, this study investigated age-related and sex-related differences between the FRN in middle and late adolescents and adults. Forty healthy adolescents (15-17 years old) ...
Cardoso Rosa R Oncology Chemistry, Worldwide Research and Development, Pfizer Inc., San Diego, California 92121, - - 2012
The heterodimer HIF-1α (hypoxia inducible factor)/HIF-β (also known as ARNT-aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small molecules in the binding interface between their C-terminal heterodimerization (PasB) domains. Taking advantage of ...
Wolf George G USAF School of Aerospace Medicine, Hyperbaric Medicine Department, Wilford Hall Ambulatory Surgical Center, Lackland AFB, Texas, - - 2012
In this single-center, double-blind, randomized, sham-controlled, prospective trial at the U.S. Air Force School of Aerospace Medicine, the effects of 2.4 atmospheres absolute (ATA) hyperbaric oxygen (HBO₂) on post-concussion symptoms in 50 military service members with at least one combat-related, mild traumatic brain injury were examined. Each subject received 30 ...
Cheng Chun-Ho CH Department of Biochemistry and Institute of Basic Medical Sciences, National Cheng Kung University College of Medicine, Tainan 701, - - 2012
Dendroaspin (Den) and rhodostomin (Rho) are snake venom proteins containing a PRGDMP motif. Although Den and Rho have different 3D structures, they are highly potent integrin inhibitors. To study their structure, function, and dynamics relationships, we expressed Den and Rho in Pichia pastoris. The recombinant Den and Rho inhibited platelet ...
Shihab Hashem A - - 2013
The rate at which nonsynonymous single nucleotide polymorphisms (nsSNPs) are being identified in the human genome is increasing dramatically owing to advances in whole-genome/whole-exome sequencing technologies. Automated methods capable of accurately and reliably distinguishing between pathogenic and functionally neutral nsSNPs are therefore assuming ever-increasing importance. Here, we describe the Functional ...
Peng Yuanlin - - 2012
ABSTRACT: Genetic variation in the capacity to repair radiation damage is an important factor influencing both cellular and tissue radiosensitivity variation among individuals as well as dose rate effects associated with such damage. This paper consists of two parts. The first part reviews some of the available data relating to ...
Pierce J Thomas - - 2012
Access "The Action Level"® Questions online at: http://www.acgih.org/products/joeh/alquestions.htm Access "The Action Level"® Answers online at: http://www.acgih.org/products/joeh/alanswers.htm Access "The Action Level"® Registration Form online at: https://www.acgih.org/products/joeh/alregfrm.htm "The Action Level,"® a self-study, continuing education program, provides a convenient and interesting opportunity for individuals to expand their knowledge in relevant areas of industrial ...
Ak Güliz - - 2012
Folate-targeted drug delivery has become an alternative therapy for the treatment of various cancers. Folate receptors are known to be responsible for cellular accumulation of folate and folate analogs with high binding affinity. The anthracycline antibiotic doxorubicin has a broad spectrum of antineoplastic action and a correspondingly widespread degree of ...
Hallanger Ingeborg G - - 2012
Levels of persistent organic pollutants (POP), such as polychlorinated biphenyls (PCB), are high in many Arctic top predators, including the Arctic fox (Vulpes lagopus). The aim of this study was to examine possible endocrine-disruptive effects of dietary POP exposure in male juvenile Arctic foxes in a controlled exposure experiment. The ...
Blakely Eleanor A - - 2012
The scientific basis for the physical and biological effectiveness of particle radiations has emerged from many decades of meticulous basic research. A diverse array of biologically relevant consequences at the molecular, cellular, tissue, and organism level have been reported, but what are the key processes and mechanisms that make particle ...
Paganetti Harald - - 2012
With the average age of radiation therapy patients decreasing and the advent of more complex treatment options comes the concern that the incidences of radiation-induced cancer might increase in the future. The carcinogenic effects of radiation are not well understood for the entire dose range experienced in radiation therapy. Longer ...
Alonso Jose R - - 2012
ABSTRACT: "Medicine and Biology" was one of five working groups of the "Accelerators for America's Future" Workshop held October 2009. The recently-released workshop report stresses that the leadership position of the United States in fields where accelerators play an important part is being seriously eroded because of lack of coordinated ...
Qin Hao - - 2012
The effect of temperature on the growth and L-lactic acid production of Lactobacillus casei G-03 was investigated in a 7-L bioreactor. It was found that the maximum specific growth rate (0.27 hr(-1)) and L-lactic acid concentration (160.2 g L(-1)) were obtained at a temperature of 41°C. Meanwhile, the maximum L-lactic acid yield, productivity, ...
Tabocchini Maria Antonella - - 2012
ABSTRACT: Development of new radiotherapy strategies based on the use of hadrons, as well as reduction of uncertainties associated with radiation health risk during long-term space flights, requires increasing knowledge of the mechanisms underlying the biological effects of charged particles. It is well known that charged particles are more effective ...
McGowan Ian I University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. - - 2012
Individuals practicing unprotected receptive anal intercourse are at particularly high risk of HIV infection. Men who have sex with men (MSM) in the developed and developing world continue to have disproportionate and increasing levels of HIV infection. The past few years have seen important progress in demonstrating the efficacy of ...
Durante Marco - - 2012
ABSTRACT: Heavy charged particles produce biological damage that is different from that normally produced by sparsely ionizing radiation, such as x- or gamma-rays, which are a large component of the natural radiation background. In fact, as a result of the different spatial distribution of the energy deposited along the core ...
Batista Bruno Lemos - - 2012
Food safety is a global concern. Meat represents the most important protein source for humans. Thus, contamination of meat products by nonessential elements is a ready source of human exposure. In addition, knowledge of the concentration of essential elements is also relevant with respect to human nutrition. The aim of ...
Escher Beate I BI National Research Centre for Environmental Toxicology (Entox), The University of Queensland, Brisbane, QLD 4108, Australia. - - 2012
The reporter gene assay AREc32 is based on the induction of the Nrf2 mediated oxidative stress response pathway in the human breast cancer cell line MCF7, where eight copies of the antioxidant response element (ARE) are linked to a reporter gene encoding for luciferase. The Nrf2-ARE pathway is responsive to ...
Kim Myung-Hee Y - - 2012
ABSTRACT: Exposure to ionizing radiation in the space environment is one of the hazards faced by crews in space missions. As space radiations traverse spacecraft, habitat shielding, or tissues, their energies and compositions are altered by interactions with the shielding. Modifications to the radiation fields arise from atomic interactions of ...
Gerrard Paul - - 2012
Age is an important prognostic indicator of outcomes following traumatic brain injuries. This study examines how outcomes for traumatic brain injuries in the acute care setting have changed during a recent 10-year period. Population-level data broken down by age group was obtained from the Agency for Healthcare Research and Quality ...
Matthews Lynn T LT Massachusetts General Hospital, Center for Global Health and Division of Infectious Disease, Boston, USA. - - 2012
Many men and women living with HIV and their uninfected partners attempt to conceive children. HIV-prevention science can be applied to reduce sexual transmission risk while respecting couples' reproductive goals. Here we discuss antiretrovirals as prevention in the context of safer conception for HIV-serodiscordant couples. Antiretroviral therapy (ART) for the ...
Brun J M - - 2012
Ducks (common, Muscovy and mule ducks) are the third most important bird species in animal production for human consumption worldwide. Our study aimed to improve the efficiency of mule duck breeding, thus contributing to the efficiency of food production in general. In the common duck, females can be bred either ...
Cucinotta Francis A - - 2012
ABSTRACT: Cigarette smoking, which is presently associated with more than 20% of adult deaths in the United States, is a large confounder to radiation risk estimates derived from epidemiology data. Astronauts and other exposed groups are classified as never-smokers (NS), defined as lifetime use of less than 100 cigarettes. In ...
Shrivastava Abhinav - - 2012
L-Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and other related malignancies. Its further use includes reduction of asparagine concentration in food products, which may lead to formation of acrylamide. Currently bacterial asparaginase is produced at industrial scale, but the enzyme isolated from bacterial origin is ...
Zeitlin Cary - - 2012
ABSTRACT: In this paper, the basic physics by which energetic charged particles deposit energy in matter is reviewed. Energetic charged particles are used for radiotherapy and are encountered in spaceflight, where they pose a health risk to astronauts. They interact with matter through nuclear and electromagnetic forces. Deposition of energy ...
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