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Benjaminsen Rikke V RV Department of Micro- and Nanotechnology, Technical University of Denmark, DTU Nanotech, Lyngby, - - 2013
Polycations such as polyethylenimine (PEI) are used in many novel nonviral vector designs and there are continuous efforts to increase our mechanistic understanding of their interactions with cells. Even so, the mechanism of polyplex escape from the endosomal/lysosomal pathway after internalization is still elusive. The "proton sponge " hypothesis remains ...
Li Jun - - 2012
The catalytic enantioselective fluorination of N-H-free 3-substituted oxindoles was accomplished by Sc(III)/N,N'-dioxide complex. Under mild reaction conditions, a series of 3-aryl- and 3-alkyl-3-fluoro-2-oxindoles were obtained in excellent yields (up to 98%) and enantioselectivities (up to 99% ee) by using N-fluorobisbenzenesulphonimide (NFSI) as the fluorination agent. MaxiPost was synthesized efficiently in ...
Messmer Andreas T - - 2012
Determining the structure of reactive intermediates is the key to understanding reaction mechanisms. To access these structures, a method combining structural sensitivity and high time resolution is required. Here ultrafast polarization-dependent two-dimensional infrared (P2D-IR) spectroscopy is shown to be an excellent complement to commonly used methods such as one-dimensional IR ...
Patel Dipam - - 2012
A series of peptidomimetics containing bidentate pTyr mimetics (9a-w) are reported as potent and selective PTP1B inhibitors. Compounds (9p and 9q) showed excellent selectivity towards PTP1B over various PTPs, including TCPTP (in vitro), confirms discovery of highly potent and selective PTP1B inhibitors.
Tamada Koji - - 2012
PURPOSE: To develop an adaptable gene-based vector that will confer immune cells specificity to various cancer types. EXPERIMENTAL DESIGN: Human and mouse T cells were genetically engineered to express a chimeric antigen receptor (CAR) that binds a fluorescein isothiocyanate (FITC) molecule, termed anti-FITC CAR T cells. Various antibodies (Abs) currently ...
Nonoo Rebecca H - - 2012
Birds of a tether: A tethering strategy for the site-directed discovery of low-molecular-weight fragments that bind weakly to defined protein surfaces is described. A solvent-exposed protein thiol captures acrylamide-modified fragments in a conjugate addition reaction that requires a template to produce a measureable quantity of protein-fragment adduct, which can be ...
Ezekowitz Justin A - - 2012
BACKGROUND: -Randomized controlled trials (RCT) are limited by their generalizability to the broader non-trial population. In order to provide a context for the Acute Study of Nesiritide in Decompensated Heart Failure (ASCEND-HF) trial, we designed a complementary registry to characterize clinical characteristics, practice patterns, and in-hospital outcomes of acute heart ...
Tunney Tyler D - - 2012
Macroscopic ecosystem properties, such as major material pathways and community biomass structure, underlie the ecosystem services on which humans rely. While ecologists have long sought to identify the determinants of the trophic height of food webs (food chain length), it is somewhat surprising how little research effort is invested in ...
Lynch Kristle L KL Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, - - 2012
Pneumatic dilation (PD) and laparoscopic Heller myotomy (LHM) can be definitive therapies for achalasia; recent data suggest comparable efficacy. However, risk must also be considered. We reviewed the major complication rate of PD and LHM in a high-volume center and reviewed the corresponding literature. We reviewed 12 years of our ...
Torrey Antonia Rae - - 2012
OBJECTIVE: To develop and psychometrically evaluate an instrument designed to measure the treatment fidelity associated with implementation of the I Am Concerned (IAC) brief opportunistic intervention by frontline, prenatal, primary care staff. DESIGN: A methodologic approach framed development of the IAC Treatment Fidelity Instrument in a six-phase protocol. SETTING: A ...
Botling Johan - - 2012
Background: Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict prognosis and therapy response. So far, the value of these multi-gene signatures in clinical practice is unclear and the biological importance of individual genes is difficult ...
Canton Irene I The Krebs Institute, University of Sheffield, Sheffield, - - 2013
There is an emerging need both in pharmacology and within the biomedical industry to develop new tools to target intracellular mechanisms. The efficient delivery of functionally active proteins within cells is potentially a powerful research strategy, especially through the use of antibodies. In this work, we report on a nanovector ...
Zhu Rongshun - - 2012
The mechanism for sublimation of NH4N(NO2)2 (ADN) has been investigated quantum-mechanically with generalized gradient approximation plane-wave density functional theory calculations; the solid surface is represented by a slab model and the periodic boundary conditions are applied. The calculated lattice constants for the bulk ADN, which were found to consist of ...
Walewski Lukasz - - 2012
Combined effects of hydrogen bonding and thermal fluctuations on the structure and infrared spectra of the formamide-formamidine dimer, FM···FI, are studied using ab initio molecular dynamics simulations. The equilibrium structure of the dimer is stabilized by two hydrogen bonds that form a pattern reminiscent of that, found in the adenine-thymine ...
Dar N A - - 2012
Although cigarette smoking is an established risk factor for oesophageal squamous cell carcinoma (ESCC), there is little information about the association between other smoking and smokeless tobacco products, including hookah and nass, and ESCC risk. We conducted a case-control study in Kashmir Valley, India, where hookah smoking, nass chewing, and ...
Mehta Suneela - - 2012
Aim: To examine whether use of a standardized cardiovascular disease (CVD) risk assessment recommended by national guidelines is associated with appropriate initiation and maintenance of medication in a large primary care cohort.Methods and design: A total of 90,631 people aged 30-80 years were followed for up to 3 years after ...
Crijns Harry J - - 2012
ABSTRACT: BACKGROUND: Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients, but the healthcare environment due to high rates of morbidity, mortality, and medical resource utilization. There are limited data on the variation in treatment practice patterns across different countries, healthcare settings and ...
Tan Qingqiao - - 2012
Because of rapidly increasing market demand and rising cost pressure, the innovator of etanercept (Enbrel (®) ) will inevitably face competition from biosimilar versions of the product. In this study, to elucidate the differences between the reference etanercept and its biosimilars, we characterized and compared the quality attributes of two ...
Miller Thomas Marshall - - 2012
Rate coefficients and branching fractions have been measured for electron attachment to perfluoromethylcyclohexane, C7F14, along with thermal detachment rate coefficients for C7F14-, from 300 to 630 K, using a flowing-afterglow Langmuir-probe apparatus. The attachment rate coefficient at room temperature is 4.5 ± 1.2 × 10-8 cm3 s-1, and increases with ...
Takayama Kei - - 2012
Purpose: To compare the phototoxicity of indocyanine green (ICG) and Brilliant Blue G (BBG) in cultured retinal pigment epithelial (RPE) cells under fluorescent lamp illumination imitating ambient light. Methods: Cultured human RPE line cells were stained with ICG or BBG solution at concentrations of clinical use, and cultured in a ...
Bastarache Julie A JA Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2650, USA. - - 2012
Systemic blockade of tissue factor (TF) attenuates acute lung injury (ALI) in animal models of sepsis but the effects of global TF deficiency are unknown. We used mice with complete knockout of mouse TF and low levels (∼1%) of human TF (LTF mice) to test the hypothesis that global TF ...
Lakshminarayan Kamakshi K Department of Neurology, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA. - - 2012
Dysphagia screening (DS) before oral intake in patients with acute stroke is a hospital-level performance measure. We report outcomes of an initiative to improve compliance to this quality measure. The design was a pre- versus postintervention comparison study. The Intervention was an electronic medical record-based clinical DS system embedded within ...
Mao Xianyun X Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, - - 2013
Recent studies suggest that rare variants play an important role in the etiology of many traits. Although a number of methods have been developed for genetic association analysis of rare variants, they all assume a relatively homogeneous population under study. Such an assumption may not be valid for samples collected ...
Xu Wei - - 2012
Access to a chiral C(82)  cage: Encaging a divalent samarium atom has provided access to an unexplored chiral cage of C(2) (5)-C(82) that has never been reported for trivalent M@C(82) or empty fullerenes. Inside this cage, a wandering Sm atom has been identified using crystallographic methods. In addition, electrochemical studies of ...
Kino Tomoshige - - 2012
Organisms face unforeseen short- and long-term changes in the environment (stressors). To defend against these changes, organisms have developed a stress system that includes the hypothalamic-pituitary-adrenal (HPA) axis, which employs glucocorticoids and the glucocorticoid receptor (GR) for signal transduction. In addition, organisms live under the strong influence of day-night cycles ...
Tran Bich - - 2012
OBJECTIVES:Ecological studies have suggested an inverse relationship between latitude and risks of some cancers. However, associations between solar ultraviolet radiation (UVR) exposure and esophageal cancer risk have not been fully explored. We therefore investigated the association between nevi, freckles, and measures of ambient UVR over the life-course with risks of ...
Bluekens Adriana M J - - 2012
Purpose:To compare screen-film mammography with digital mammography in a breast cancer screening program, with a focus on the clinical relevance of detected cancers.Materials and Methods:The study was approved by the regional medical ethics review board. Informed consent was not required. Before the nationwide transition to digital mammography in the Dutch ...
Leng Qixin Q Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, - - 2012
Induction of cytokines by small interfering RNA (siRNA) polyplexes has been a significant concern of researchers attempting to minimize the toxicity of this promising therapy. Although cationic carriers of siRNA are known to increase cytokine levels, few systematic studies have been done to determine what properties of the carrier are ...
Cortese Juliann - - 2012
Abstract As the United States prepares for the 2012 Presidential Election, we reflect on how the 2008 candidates and the voting public adopted social computing technology with specific focus on YouTube. Using the Social Influence Model as a framework, this article sought to examine how candidates adopted YouTube to determine ...
Hempel Klaus - - 2012
Approximately 3-20% of all reticulocytes in blood of healthy persons are immature and transferrin receptor positive (Tf-Ret). Tf-Ret were measured by flow cytometry in 27 patients treated with three different radiopharmaceuticals labeled with (131)I and in 25 healthy controls. Patients were chronically exposed within 6 days to blood doses from ...
Kaye Stanley B SB Royal Marsden Hospital, Sutton, Surrey, United Kingdom. - - 2012
Hedgehog pathway inhibition has been suggested as a potential maintenance treatment approach in ovarian cancer through disruption of tumor-stromal interactions. Vismodegib is an orally available Hedgehog pathway inhibitor with clinical activity in advanced basal cell carcinoma and medulloblastoma. This phase II, randomized, double-blind, placebo-controlled trial was designed to provide a ...
Williams Hywel D - - 2012
The LFCS Consortium was established to develop standardized in vitro tests for lipid-based formulations (LBF) and to examine the utility of these tests to probe the fundamental mechanisms that underlie LBF performance. In this publication, the impact of bile salt (sodium taurodeoxycholate, NaTDC) concentration and LBF drug loading on the ...
Liu Ketang - - 2012
A functionalized periodic mesoporous organosilica with incorporated chiral bis(cyclohexyldiamine)-based Ni(II) complexes within the silica framework was developed by the co-condensation of (1R,2R)-cyclohexyldiamine-derived silane and ethylene-bridge silane, followed by the complexation of NiBr(2) in the presence of (1R,2R)-N,N'-dibenzylcyclohexyldiamine. Structural characterization by XRD, nitrogen sorption, and TEM disclosed its orderly mesostructure, and ...
Kocabay Ozge O Department of Chemistry, Faculty of Science, Ankara University, Tandogan , Ankara , - - 2013
A novel highly sensitive electrochemical carboxymethylcellulose-gelatin-superoxide dismutase biosensor was used for the determination of superoxide radicals enhancement in tomato plants exposed to salinity, drought, cold and heavy metal stress. The variations in superoxide radicals depending on abiotic stress was determined using biosensor. The superoxide radical production with regard to control ...
Li W C WC Department of Trauma Orthopedics, Second People's Hospital of Shenzhen, Guangdong Province, P. R. - - 2013
To study the adhesion, proliferation and expression of bone marrow mesenchymal stem cells (BMSCs) on nano-hydroxyapatite (Nano-HA) bone graft material after transfection of adenovirus-mediated human bone morphogenetic protein-2 expression vector (Ad-BMP-2). BMSCs were transfected using Ad-BMP-2. Immunohistochemistry and Western blot were used to detect BMP-2 expression in transfected cells. After ...
Penberthy Lynne - - 2012
BACKGROUND: Clinical trials (CTs) are the mechanism by which research is translated into standards of care. Low recruitment among underserved and minority populations may result in inequity in access to the latest technology and treatments, compromise the generalizability, and lead to failure in identification of important positive or negative treatment ...
Leroi A M - - 2012
OBJECTIVES:The objective of this study was to show that although transcutaneous electrical tibial nerve stimulation (TENS) is being increasingly used to treat fecal incontinence (FI), its efficacy has never been proved using controlled trials.METHODS:In this randomized, double-blind, sham-controlled trial, 144 patients aged 30-82 years from nine centers were randomly assigned ...
Staffa Katharina - - 2012
Gene expression of specific brain biomarkers offers the possibility to shed light on the diffi-cult molecular pathways of traumatic brain injury (TBI) and may be useful to estimate the age of trauma. Gene expression rates of cerebellar injuries are not yet sufficiently established. In 12 cases of TBI including a ...
Scherbaum Charles A - - 2012
A concern about personality inventories in diagnostic and decision-making contexts is that individuals will fake. Although there is extensive research on faking, little research has focused on how perceptions of personality items change when individuals are faking or responding honestly. This research demonstrates how the delta parameter from the generalized ...
Benitez-Herreros Javier - - 2012
PURPOSE: To evaluate the effect of the cannula removal technique on postoperative vitreous incarceration using an experimental model of vitrectomized eye. METHODS: In a prospective, experimental, randomized and observer-masked study, 118 cadaveric pig eyes were vitrectomized through 23-gauge transconjunctival sclerotomies. Once vitrectomy was finished, one of the superior cannulas was ...
Liu Jiyang - - 2012
A new nanocomposite material for enzyme immobilization and subsequent direct electrochemistry and electrocatalysis was developed by using 1,2-dimyristoyl-sn-glycero-3-phospho-(1-rac-glycerol)-phospholipid-monolayer-membrane-modified graphene (DMPG-G). Microperoxidase-11 (MP11) was chosen as a model enzyme to investigate the composite system. Owing to the improved conductivity and biocompatible microenvironment, MP11 that was immobilized in the matrix of the ...
Comper Maria L C - - 2012
BACKGROUND: Most of the available instruments aimed to assess risk exposure associated with work-related musculoskeletal disorders were originally developed in English, which makes their use difficult in countries such as Brazil. OBJECTIVE: To test the clinimetric properties of the Quick Exposure Check (QEC) instrument previously adapted into Brazilian-Portuguese. METHOD: The ...
Crespo-Otero Rachel - - 2012
The photochemistry of N-methylformamide (MF) is elucidated by investigating its photodissociation products generated by UV irradiation (248 nm) in an argon matrix (10 K). We find that, starting from trans-MF, prolonged irradiation produces cis-MF, CH(3) NH(2) and CO fragments as major products. Another photoproduct is identified as methylformimidic acid (FIA). Nonadiabatic dynamics ...
Gao Hongwei H Department of Blood Biochemistry and Molecular Biology, Beijing Institute of Transfusion Medicine, Beijing, PR - - 2013
Enzymatical conversion of A or B RBCs into group O RBCs (ECORBCs) was achieved by using α-N-acetylgalactosaminidase and α-galactosidase, respectively. Now, we initiated AB to O-RBC conversion by using these two enzymes together. But α-N-acetylgalactosaminidase and α-galactosidase's preserving and their reaction buffer were quite different. The aim of this study ...
Rose P C - - 2012
BACKGROUND: Treatment options for drug-resistant tuberculosis (DR-TB) are limited. Linezolid has been successfully used to treat DR-TB in adults, but there are few case reports of its use in children for TB. The reported rate of adverse events in adults is high.METHODS: We conducted a retrospective review of children with ...
Schmitt Christian M - - 2012
Background: A free gingival graft (FGG) is currently the gold standard for augmenting small areas of keratinized mucosa. The porcine collagen matrix (CM) represents an alternative to autologous tissue harvesting. This study aimed to compare the CM versus FGGs for augmenting keratinized peri-implant mucosa, based on clinical and histological evaluations. ...
Dumas Orianne - - 2012
OBJECTIVE: Cleaning products may cause work-related asthma, but information regarding the specific exposures involved is scarce. We aimed to determine the associations between asthma and occupational exposure to cleaning agents in hospital workers. METHODS: Analyses were conducted in 179 (136 women) hospital workers and a reference population of 545 subjects ...
Liu Weihui - - 2012
Breast cancer resistance protein 1 (BCRP1/ABCG2) is used to identify the side population (SP) within a population of cells, which is enriched for stem and progenitor cells in different tissues. Here, we investigated the role of extracellular-regulated kinase (ERK) 1/2 in the signaling mechanisms underlying ischemic/hypoxic conditions in kidney SP ...
Jakobsen Lars - - 2012
BACKGROUND: THE ASSOCIATION BETWEEN LOW SOCIOECONOMIC STATUS (SES) AND HIGH MORTALITY FROM CORONARY HEART DISEASE IS WELL-KNOWN. HOWEVER, THE ROLE OF SES IN RELATION TO THE CLINICAL OUTCOME AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION REMAINS POORLY UNDERSTOOD.METHODS AND RESULTS: WE STUDIED 7385 PATIENTS TREATED WITH PRIMARY PERCUTANEOUS CORONARY INTERVENTION. PARTICIPANTS WERE ...
Bohle D Scott - - 2012
The facile axial ligand exchange properties of gallium(III) protoporphyrin IX in methanol solution were utilized to explore self-association interactions by NMR techniques. Structural changes were observed, as well as competitive behavior with the ligands acetate and fluoride, which differed from that seen with the synthetic analogue gallium(III) octaethylporphyrin which lacks ...
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