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Jin Yu - - 2012
Colonic administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced acute colitis in mice and elicited a Th1 immune response. Th17 cells are believed to play a major role in TNBS-induced colitis. The aim of this study is to investigate the roles of interleukin (IL)-17 and interferon (IFN)-γ in the pathogenesis of ...
Baklouti-Gargouri Siwar - - 2012
Cytochrome c oxidase encoded by multiple mitochondrial genes (COXI, COXII, and COXIII) and nuclear genes is an essential component of the mitochondrial respiratory chain that catalyzes the reduction of molecular oxygen by reduced cytochrome c. Subunits COXI and COXII of cytochrome c oxidase are known to play the most essential ...
Engmann Sarah - - 2012
Relative cross sections for dissociative electron attachment (DEA) and dissociative ionization (DI) of the FEBID precursor, trimethyl (methylcyclopentadienyl) platinum(iv), MeCpPtMe(3), are presented. The most pronounced DEA process is the loss of one methyl radical, while the loss of two or three methyl groups along with hydrogen is the main pathway ...
Anand Sushant - - 2012
Nanotextured superhydrophobic surfaces have received significant attention due to their ability to easily shed liquid drops. However, water droplets have been shown to condense within the textures of superhydrophobic surfaces, impale the vapor pockets, and strongly pin to the surface. This results in poor droplet mobility and degrades condensation performance. ...
Luria Justin L - - 2012
We present spatially-resolved photovoltage spectra of a bulk heterojunction solar cell film comprised of phase-separated poly(9,9`-dioctylfluorene-co-benzo-thiadiazole) (F8BT) and poly(9,9`-dioctylfluorene-co-bis-N,N`-(4-butylphenyl)-bis-N,N`-phenyl-1,4-phenylene-diamine) (PFB) polymers prepared on ITO/PEDOT:PSS and aluminum substrates. Over both PFB- and F8BT-rich domains the photopotential spectra were found to be proportional to a linear combination of the polymers' absorption spectra. ...
Carlson Misty - - 2012
BACKGROUND: Girls and women with Turner syndrome are at risk for aortic dissection and rupture. However the size of the aorta and the clinical characteristics among those with Turner syndrome and dissection has received little attention. METHODS AND RESULTS: We obtained medical records from 20 individuals who voluntarily participated in ...
Mattei Tobias A - - 2012
Object Bicycle accidents are a very important cause of clinically important traumatic brain injury (TBI) in children. One factor that has been shown to mitigate the severity of lesions associated with TBI in such scenarios is the proper use of a helmet. The object of this study was to test ...
Bi Yingpu - - 2012
Two-dimensional dendritic Ag(3)PO(4) nanostructures have been synthesized in high-yield by reacting Ag nanowires with H(2)O(2) and NaH(2)PO(4) in aqueous solution at room temperature, which exhibit much higher photocatalytic activities than irregular Ag(3)PO(4) nanocrystals and N-doped TiO(2) catalyst for the degradation of organic contaminants under visible light irradiation.
Karolina Dwi Setyowati - - 2012
Context:Coordinated interplay of dysregulated microRNAs in isolated metabolic disorder is implicated in the pathogenesis of metabolic syndrome.Objective:The objective of the study was to characterize microRNA expression in the blood and exosomes of individuals with metabolic syndrome and compare them with those manifesting one of the metabolic vascular risk factors (type ...
Nicolini A - - 2012
The use of non-invasive ventilation (NIV) in acute hypoxemic respiratory failure (AHRF) due to H1N1 virus infection is controversial. In this multicenter study we aimed to assess the efficacy of NIV in avoiding endotracheal intubation (ETI) and to identify predictors of success or failure. In this prospective multicenter study, 98 ...
Khemees Tariq A - - 2012
Background and Purpose: Numerous holmium:YAG laser fibers are available for flexible ureteroscopy. Fibers performance and durability can vary widely amongst different manufacturers and their product lines with differences within a single product line have been reported. We sought to evaluate a newly developed non-tapered, single-use 240 µm fiber, Flexiva™ 200 ...
Zadegan Reza M - - 2012
The DNA origami technique is a recently developed self-assembly method that allows construction of 3D objects at the nanoscale for various applications. In the current study we report the production of a 18×18×24 nm(3) hollow DNA box origami structure with a switchable lid. The structure was very efficiently produced and ...
Brondani Leticia A - - 2012
Purpose. Uncoupling protein 1 (UCP1) reduces mitochondrial production of reactive oxygen species (ROS). ROS overproduction is related to diabetic retinopathy (DR), a chronic complication of diabetes mellitus (DM). Therefore, deleterious polymorphisms in UCP1 gene are candidate risk factors for DR. We investigated the relationships between the UCP1 -3826A/G polymorphism and ...
Hu Lin - - 2012
A new facile strategy has been designed to fabricate spinel Mn(x) Co(3-x) O(4) porous nanocubes, which involves a morphology-conserved and pyrolysis-induced transformation of Prussian Blue Analogue Mn(3) [Co(CN)(6) ](2) ⋅nH(2) O perfect nanocubes. Owing to the release of CO(2) and N(x) O(y) in the process of interdiffusion, this strategy can ...
Vasan Ganesh - - 2012
The finite element method (FEM) was used to solve the time-harmonic Maxwell equations in a study of the effect of the incidence angle of infrared light on the surface enhancement caused by colloidal gold particles in attenuated total reflection surface enhanced infrared absorption spectroscopy (ATR-SEIRAS). The spectral enhancement factor was ...
Langton Matthew J - - 2012
The chloride-templated synthesis of a novel [3]rotaxane, capable of binding anionic guests, and incorporating a naphthalene group for fluorescence sensing is reported. Extensive (1) H NMR titration studies were used to probe the anion binding selectivity of the system. The rotaxane selectively recognises sulfate, undergoing an induced conformational change upon sulfate ...
Anitha Ayyappan - - 2012
Background: Synaptic dysfunction has been shown to be involved in the pathogenesis of autism. We hypothesized that the protocadherin α gene cluster (PCDHA), which is involved in synaptic specificity and in serotonergic innervation of the brain, could be a suitable candidate gene for autism. Methods: We examined 14 PCDHA single ...
Park In-Won - - 2012
A new ditopic ion-pair receptor 1 was designed, synthesized, and characterized. Detailed binding studies served to confirm that this receptor binds fluoride and chloride ions (studied as their tetraalkylammonium salts) and forms stable 1:1 complexes in CDCl(3) . Treatment of the halide-ion complexes of 1 with Group I and II metal ...
Schmidt Sebastian - - 2012
The (1)H NMR-guided fractionation of a petroleum ether extract of Hypericum empetrifolium led to the isolation of four new bicyclic (1-4), four known bicyclic (5-8), three new tricyclic (9-11), and three new polycyclic acylphloroglucinols (12/13 and 14) possessing a monoterpenoid citran moiety. Compounds 12/13 were isolated as a mixture of ...
Pureza Rita - - 2012
The tip-of-the-tongue (TOT) state is a common experience, usually coupled with a frustrating feeling caused by the incapability of retrieving a familiar word. It is thought that TOTs occur when the semantic and syntactic information of the word is retrieved but not its phonology. This study aims to further understand ...
Matsuda Ryusaku - - 2012
Purpose:We have reported that calcitonin gene-related peptide gene-transfected mature dendritic cells (mDC) suppress murine experimental autoimmune optic neuritis (EAON) and experimental autoimmune encephalitis (EAE) via IL-10 production. In this study, we examined whether IL-10-transfected mDC prevent development of EAON and EAE. Methods:A plasmid expressing mouse IL-10 was constructed, and used ...
Zheng Ke - - 2012
The completely OH-selective Prins cyclization has been realized from the enantioselective ene reaction product. A variety of 4-hydroxyl-tetrahydropyrans were exclusively generated via FeCl3 catalyzed Prins reaction. Excellent stereoselectivities (up to >99:1 dr and >99.5:0.5 er) were obtained for a remarkably broad substrates under mild reaction conditions. The control experiments, including ...
Shiota Masaki - - 2012
Oxidative stress caused by an increase in reactive oxygen species levels or a decrease in the cellular antioxidant capacity can evoke modulation of various cellular events including androgen receptor (AR) signaling via direct or indirect interaction. In this review we summarize the mechanisms of AR activation by oxidative stress including: ...
Tsivian M - - 2012
Background:To investigate racial differences in tumor burden (cancer volume, cancer percentage and cancer to PSA ratios) in a large cohort of men undergoing radical prostatectomy (RP).Methods:Demographic, clinical and pathological data of patients undergoing RP between 1993-2010 were reviewed and compared between African-American (AA) and non African-American (nAA) men. Further assessments ...
Su Yu-Sheng - - 2012
Realization of a ubiquitous clean energy future depends critically on the efficient storage and utilization of renewable energies. Lithium-ion batteries are appealing in this regard, but low-cost, abundant, safe, high energy-density electrode materials need to be developed to adopt them. Here we present a sulfur-multi-wall carbon nanotube (MWCNT) composite cathode ...
Wohlers Janet - - 2012
ABSTRACT: INTRODUCTION: In granulomatosis with polyangiitis (GPA), a complex autoimmune small-vessel vasculitis frequently associated with chronic necrotizing inflammation of the nasal mucosa, elevated nasal Staphylococcus (S.) aureus carrier rates are a risk factor for relapse. As cytokines are primarily involved in the regulation of defense against potentially pathogenic microorganisms, the ...
Mao Mao - - 2012
We synthesized a series of donor-substituted tridurylboranes containing different types and number of chromophores including 1-pyrene (PB1-3), 3-carbazole (CBC1-3), or substituted p-carbazol-N-phenyl (CBN3a-c) as various donor-acceptor (D-A) molecules. The photophysical and electrochemical properties of these twisted D-A molecules were investigated by means of UV/Vis absorption and fluorescence spectroscopy as well ...
Devnani Mahesh - - 2012
Introduction The first decade of the 21st century has witnessed three major influenza public health emergencies: (1) the severe acute respiratory syndrome of 2002-2003; (2) the avian flu of 2006; and (3) the 2009 H1N1 pandemic influenza. An effective public health response to an influenza public health emergency depends on ...
Chamorro S - - 2012
Polyphenols are chemically and biologically active compounds. Grape seed extracts (GSEs) have been widely used as a human food supplement for health promotion and disease prevention. However, there is little information regarding its application in animal feeds. An experiment was conducted to investigate the effect of inclusion of GSE at ...
Barreira Rebeca Iglesias - - 2012
OBJECTIVE:To report a paradoxical reaction of Raynaud phenomenon following the repeated administration of iloprost in a patient with diffuse cutaneous systemic sclerosis with vascular involvement.CASE SUMMARY:In January 2006, a 40-year-old male was diagnosed with diffuse cutaneous systemic sclerosis with pulmonary, esophageal, cutaneous, and vascular involvement (Raynaud phenomenon, with digital ulcers ...
Gowda Charitha - - 2012
Background: There has been a rise in the number of vaccine-hesitant parents (VHPs) in the US, many of whom express reservations about administering the MMR vaccine to their children. We studied the relative importance of attitudinal barriers to MMR vaccination among VHPs with differing levels of MMR vaccine-hesitancy.   Methods: ...
Botta Roberta - - 2012
Background Orbital fibroblast proliferation and hyaluronic acid (HA) release are responsible for some of the clinical features of Graves' Ophthalmopathy (GO). Thus, inhibition of these processes may be a possible therapeutic approach to this syndrome. Enalapril, a widely used anti-hypertensive drug, was found to have some inhibitory actions on fibroblast ...
Kim Jae Hui - - 2012
Purpose: To investigate changes in thickness profiles of retinal layers after resolution of recent-onset rhegmatogenous retinal detachment Methods: Spectral domain optical coherence tomography (SD-OCT) scans were performed for 28 patients diagnosed with unilateral inferior-half or superior-half retinal detachment who underwent retinal reattachment surgery. The thickness of each retinal layer was ...
Nguyen Christine - - 2012
Objective :  Our study aimed to use national data to assess the perioperative outcomes of craniosynostosis surgical repair. Design :  Data were obtained from the Agency for Healthcare Research and Quality Healthcare Cost and Utilization Project Kids Inpatient Database from 1997, 2000, 2003, and 2006. Setting :  Community hospitals in ...
Cuadrado-Godia Elisa - - 2012
OBJECTIVE: To describe the severity and early neurological deterioration (END) in patients with symptomatic carotid stenosis and to analyse the influence of related factors. METHODS: Observational cohort study of patients with ischaemic stroke, ipsilateral carotid stenosis and without evidence of cardiac sources of embolism prospectively recorded since January 2003 to ...
Motiwala Shweta R - - 2012
Over the last several years, cardiac biomarkers have been shown to be increasingly useful for disease screening, diagnosis, and prognostication. The most widely used biomarkers in heart failure (HF) are natriuretic peptides, which can aid in diagnosing HF, while also identifying those diagnosed who are at higher risk of adverse ...
Yang Guochun - - 2012
We have investigated the chiroptical, linear, and second-order nonlinear optical (NLO) properties of seven binaphthol derivatives and elucidated structure-property relationships from the micromechanism for the first time. The excitation energies, oscillator strengths, and rotational strengths of the 150 lowest energy electron excitations for the most stable conformers have been calculated ...
Zimmermann Ralf - - 2012
Biohybrid hydrogels combining electrically neutral synthetic polymers and highly anionic glycosaminoglycans (GAGs) offer exciting options for regenerative therapies as they allow for the electrostatic conjugation of various growth factors. Unraveling details of ionization and structure within such networks defines an important analytical challenge that requires the extension of current methodologies. ...
Shokri Alireza - - 2012
Nature employs flexible molecules to bind anions in a variety of physiologically important processes whereas supramolecular chemists have been designing rigid substrates that minimize or eliminate intramolecular hydro-gen bond interactions to carry out anion recognition. Herein, the association of a flexible polyhydroxy alkane with chloride ion is described and the ...
Barea R - - 2012
The lipid content and fatty acid (FA) profile in pig tissues are strongly influenced by genotype and nutrient supply, with implications in meat quality. The de novo lipid synthesis and pattern of FA unsaturation could be an important cause of variation in the overall efficiency of energy utilization among breeds. ...
Wolffs Martin - - 2012
The self-assembly of two enantiomerically pure hexa(oligo (p-phenylene vinylene))-substituted benzenes having 24 stereocenters was studied in pure methylcyclohexane (MCH) and in a mixture of MCH/toluene (4:1). Irrespective of the solvent a cooperative supramolecular polymerization mechanism was determined for these star-shaped molecules by using temperature-dependent CD and UV/Vis spectroscopy. Quite remarkably, ...
Nie Kun - - 2012
A series of neutral lanthanide alkoxides supported by an amine-bridged bis(phenolate) ligand were synthesized, and their catalytic behaviors for the polymerization of rac-lactide (LA) and rac-β-butyrolactone (BBL) were explored. The reactions of (C(5)H(5))(3)Ln(THF) with amine-bridged bis(phenol) LH(2) [L = Me(2)NCH(2)CH(2)N{CH(2)-(2-OC(6)H(2)Bu(t)(2)-3,5)}(2)] in a 1:1 molar ratio in THF for 1 h ...
Mehta Suneela - - 2012
Aim: To examine whether use of a standardized cardiovascular disease (CVD) risk assessment recommended by national guidelines is associated with appropriate initiation and maintenance of medication in a large primary care cohort.Methods and design: A total of 90,631 people aged 30-80 years were followed for up to 3 years after ...
Crijns Harry J - - 2012
ABSTRACT: BACKGROUND: Atrial fibrillation is a serious public health problem posing a considerable burden to not only patients, but the healthcare environment due to high rates of morbidity, mortality, and medical resource utilization. There are limited data on the variation in treatment practice patterns across different countries, healthcare settings and ...
Tan Qingqiao - - 2012
Because of rapidly increasing market demand and rising cost pressure, the innovator of etanercept (Enbrel (®) ) will inevitably face competition from biosimilar versions of the product. In this study, to elucidate the differences between the reference etanercept and its biosimilars, we characterized and compared the quality attributes of two ...
Miller Thomas Marshall - - 2012
Rate coefficients and branching fractions have been measured for electron attachment to perfluoromethylcyclohexane, C7F14, along with thermal detachment rate coefficients for C7F14-, from 300 to 630 K, using a flowing-afterglow Langmuir-probe apparatus. The attachment rate coefficient at room temperature is 4.5 ± 1.2 × 10-8 cm3 s-1, and increases with ...
Takayama Kei - - 2012
Purpose: To compare the phototoxicity of indocyanine green (ICG) and Brilliant Blue G (BBG) in cultured retinal pigment epithelial (RPE) cells under fluorescent lamp illumination imitating ambient light. Methods: Cultured human RPE line cells were stained with ICG or BBG solution at concentrations of clinical use, and cultured in a ...
Xu Wei - - 2012
Access to a chiral C(82)  cage: Encaging a divalent samarium atom has provided access to an unexplored chiral cage of C(2) (5)-C(82) that has never been reported for trivalent M@C(82) or empty fullerenes. Inside this cage, a wandering Sm atom has been identified using crystallographic methods. In addition, electrochemical studies of ...
Tunney Tyler D - - 2012
Macroscopic ecosystem properties, such as major material pathways and community biomass structure, underlie the ecosystem services on which humans rely. While ecologists have long sought to identify the determinants of the trophic height of food webs (food chain length), it is somewhat surprising how little research effort is invested in ...
Torrey Antonia Rae - - 2012
OBJECTIVE: To develop and psychometrically evaluate an instrument designed to measure the treatment fidelity associated with implementation of the I Am Concerned (IAC) brief opportunistic intervention by frontline, prenatal, primary care staff. DESIGN: A methodologic approach framed development of the IAC Treatment Fidelity Instrument in a six-phase protocol. SETTING: A ...
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