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Som A A Department of Genitourinary Medical Oncology, Unit 1374, The University of Texas MD Anderson Cancer Center, 1155 Herman Pressler, Houston, TX 77230, - - 2012
The bone-forming metastases of prostate cancer result from complex stromal-epithelial interactions within the tumour microenvironment. Autocrine-paracrine signalling pathways between prostate cancer epithelial cells, osteoblasts, and osteoclasts stimulate aberrant bone remodelling, and the activity of these three cell populations can be quantitatively measured using prostate-specific antigen (PSA), bone-specific alkaline phosphatase (BAP) ...
Moreno Alberto - - 2012
The rate coefficients for the reaction of NO3 radical with 2-butanol, 3-methyl-2-butanol and 2,3-dimethyl-2-butanol were determined using relative rate technique in a 50 L glass pyrex photoreactor using in situ FT-IR spectroscopy at room temperature and pressure of 350-670 Torr. Rate coefficient for the reaction of 2-methyl-2-butanol with NO3 radical ...
Meier Herbert - - 2012
The dimerization of anthracene by a [4π + 4π] cycloaddition is one of the oldest and best known reactions in photochemistry. In the series of tethered bichromophoric arenes, this reaction type could be extended to anthracene-naphthalene, naphthalene-naphthalene and recently even to anthracene-benzene and naphthalene-benzene systems. Cyclophanes, which can be regarded ...
Andreoli Steven M - - 2012
ObjectiveAdenoid hypertrophy and chronic adenoiditis are associated with an increased incidence of chronic otitis media. This study intends to determine the relationship between chronic otitis media and dynamic ciliary beat frequency in children undergoing adenoidectomy.Study DesignProspective, controlled study.SettingPediatric tertiary care hospital.Subjects and MethodsChildren undergoing adenoidectomy were enrolled. Patients were stratified ...
Hartwig Andreas - - 2012
Purpose: To use a large wavefront database of a clinical population to investigate relationships between refractions and higher order aberrations and between aberrations of right and left eyes. Methods: Third and fourth-order aberration coefficients and higher-order root-mean-squared aberrations (HO RMS), scaled to a pupil size of 4.5 mm diameter, were ...
Patra Satyajit - - 2012
The microscopic structure and dynamics of the room temperature ionic liquids (RTILs) that are responsible for some of the peculiar properties of this class of solvents continue to intrigue the researchers and stimulate new investigations. Herein, we use the fluorescence correlation spectroscopy (FCS) technique to study the diffusion of some ...
Abe Yuichiro - - 2012
2,4-Trifluoromethylquinoline (TFMAQ) derivatives that have amine (1), methylamine (2), phenylamine (3), and dimethylamine (4) substituents at the 7-position of the quinoline ring were prepared and crystallized. Six crystals including the crystal polymorphs of 2 (crystal GB and YG) and 3 (crystal B and G) were obtained and characterized by X-ray ...
Xu Gang - - 2012
The preparation of crystalline, ordered thin films of metal-organic frameworks (MOFs) will be a critical process for MOF-based nanodevices in the future. MOF thin films with perfect orientation and excellent crystallinity were formed with novel nanosheet-structured components, Cu-TCPP [TCPP = 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin], by a new "modular assembly" strategy. The modular assembly ...
Persat Florence - - 2012
The migration of DCs is a critical function, enabling information to be carried to where the immunological response occurs. Parasites are known to weaken host immunity by interfering with the functions of DCs and thus, may be a source of molecules with immunomodulatory properties. Here, we demonstrate that the soluble ...
Jiang Jinqiang - - 2012
A novel coumarin-centered amphiphilic star-block polymer of has been designed to investigate the pH-induced accompanying outward movement of hydrophobic coumarin centers within the polymer micelles upon protonation.
Raviprakash Kanakatte K Viral & Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, MD, USA. - - 2012
A tetravalent DNA vaccine formulated with Vaxfectin adjuvant was shown to elicit high levels of neutralizing antibody against all four dengue virus serotypes (Porter et al., ( 16) ), warranting further testing in humans. In preparation for a phase 1 clinical testing, the vaccine and the adjuvant were manufactured under ...
Holt Cheryl L - - 2012
Colorectal cancer screening has clear benefits in terms of mortality reduction; however, it is still underutilized and especially among medically underserved populations, including African Americans, who also suffer a disproportionate colorectal cancer burden. This study consisted of a theory-driven (health belief model) spiritually based intervention aimed at increasing screening among ...
Walsh A M - - 2012
An experiment (complete randomised design) was conducted to investigate the effects of supplementing different molecular weights (MW) of chitooligosaccharide (COS) on pig performance, selected microbial populations and nutrient digestibility post-weaning. A total of 396 weaned piglets (24 days of age, 7.3 kg ± (s.d.) 1.7 kg live weight) were assigned ...
Ingale Sachin A - - 2012
A new, easy-to-prepare and highly selective, pyrene linked tris-triazole amine fluorescent chemosensor has been designed from tripropargylamine and pyrene azide using Cu(I)-catalyzed click chemistry. The fluorescence on-off sensor 1 is highly selective for Zn2+ displaying a ratiometric change in emission. The relative intensity ratio of monomer to excimer fluorescence (M376/E465) ...
Knowles Lisa O - - 2012
A group of aliphatic α,β-unsaturated carbonyl compounds were evaluated for their utility as inhibitors of sprout growth in stored potato tubers (Solanum tuberosum L.). Non-dormant tubers were treated with vapors of six, 8- to 10-carbon compounds of this chemistry. Subsequent sprout growth at 16(o)C (95% RH) over ca. 3 months ...
Ren Shuang - - 2012
Cytochrome P450 (CYP) 2J2 is one of the human CYPs involved in phase I xenobiotics metabolism. It is mainly expressed in extrahepatic tissues including intestine and cardiovascular systems. The general role of CYP2J2 in drug metabolism is not yet fully understood, while the recent discovery that CYP2J2 can metabolize a ...
Chen Jianfang - - 2012
Bcl-2 and Bcl-xL antiapoptotic proteins are attractive cancer therapeutic targets. We have previously reported the design of 4,5-diphenyl-1H-pyrrole-3-carboxylic acids as a class of potent Bcl-2/Bcl-xL inhibitors. In the present study, we report our structure-based optimization for this class of compounds based upon the crystal structure of Bcl-xL complexed with a ...
Tomson Torbjörn - - 2013
Nonrandomized studies of the relationship of antiepileptic drugs (AEDs) with sudden unexpected death in epilepsy (SUDEP) may be susceptible to confounding by tonic-clonic seizure frequency, polypharmacy, and other potential risk factors for SUDEP. We evaluated the risk of SUDEP with lamotrigine (LTG) compared to active comparators and placebo in randomized ...
Pereira Vanessa S - - 2012
BACKGROUND: Urinary incontinence (UI) is one of the most common public health problems among older women. Despite conservative treatment being recommended as the first treatment option, the effects of physical therapy in older women with UI is unclear. OBJECTIVE: This study aimed to systematically review the evidence about the effects ...
Al-Eitan Laith Naser - - 2012
Drug dependence is a pattern of repeated self-administration of a drug, which can result in tolerance, withdrawal and compulsive drug-taking behaviour. It has been recently suggested that 5-HTTLPR (LL/LS/SS) variants and rs25531 (A/G) polymorphism in the serotonin transporter gene (SLC6A4) may play a role in drug dependence. The current study ...
Jönsson Daniel - - 2012
Background: Possible synergism between female sex hormones and vitamin D on periodontitis pathology has not been assessed. Here, we investigate effects of estrogen, progesterone and vitamin D on periodontitis in a population-based sample and use cell studies to explore mechanistic explanations of the population-based findings. Methods: The epidemiological analysis utilizes ...
Minamisawa R A - - 2012
Strained Si nanowires are among the most promising transistor structures for implementation in very large-scale integration due to of their superior electrostatic control and enhanced transport properties. Realizing even higher strain levels within such nanowires are thus one of the current challenges in microelectronics. Here we achieve 4.5% of elastic ...
Yin Jingzhou - - 2012
We successfully controlled the crystallographic surface of ZnSn(OH)(6) crystals and systematically obtained ZnSn(OH)(6) crystals in different shapes including cubes, truncated cubes, cuboctahedrons, truncated octahedrons, and octahedrons using a simple solvothermal method in a methylcellulose (MC) ethanol/water solution. By simply adjusting the amount of the NaOH solution added to the reaction ...
Gonzalez F - - 2012
Acute kidney injury (AKI) is a common and frequently fatal illness in critically ill patients, with a high associated-mortality. Early recognition of kidney injury and prompt corrective measures may improve outcome. Finding an early, accurate and reproducible biomarker for AKI is a research priority. In recent years, many urinary or ...
Remizowa Margarita V - - 2012
• Premise of the study: The predominantly aquatic order Alismatales displays a highly variable flower groundplan associated with a diverse range of developmental patterns. We present the first detailed description of flower anatomy and development in Posidonia, the sole genus of the seagrass family Posidoniaceae. Existing accounts provide conflicting interpretations ...
Blankenberg Francis G - - 2012
In humans, apoptosis (programmed cell death) is the most common form of cell death after necrosis. Apoptosis is a series of genetically preprogrammed biochemical and morphologic energy-requiring events that, after a specific external or internal stimulus, results in the physiologic disappearance of a cell via its self-disintegration and packaging of ...
Son Ji-Hee - - 2012
The Colorado Department of Public Health and Environment (CDPHE) proposed the in-stream numeric nutrient criteria as 2 mg TN per L and 0.16 mg TP per L for warm surface waters and 0.40 mg TN per L and 0.11 mg TP per L for cold surface waters. Consequently the department ...
Zuckerman Scott L - - 2012
Object Several studies have suggested a gender difference in response to sports-related concussion (SRC). The Concussion in Sport group did not include gender as a modifying factor in SRC, concluding that the evidence at that point was equivocal. In the present study the authors endeavored to assess acute neurocognitive and ...
Delaney Nigel F - - 2013
Software to manage automated laboratories, when interfaced with hardware instruments, gives users a way to specify experimental protocols and schedule activities to avoid hardware conflicts. In addition to these basics, modern laboratories need software that can run multiple different protocols in parallel and that can be easily extended to interface ...
Parsian Sana S Departments of Radiology, University of Washington School of Medicine, Seattle Cancer Care Alliance, 825 Eastlake Ave E, G3-200, Seattle, WA 98109-1023, - - 2012
To evaluate the diffusion-weighted (DW) imaging characteristics of nonmalignant lesion subtypes assessed as false-positive findings at conventional breast magnetic resonance (MR) imaging. This HIPAA-compliant retrospective study had institutional review board approval, and the need for informed patient consent was waived. Lesions assessed as Breast Imaging Reporting and Data System category ...
Hu Chia-Wei - - 2012
Rhodopseudomonas palustris (R. palustris) is a purple nonsulfur anoxygenic phototrophic bacterium with metabolic versatility and able to grow under photoheterotrophic and chemoheterotrophic states. It has the ability in carbon management, carbon recycling, hydrogen generation, and lipid production; therefore it has the potential for bioenergy production and biodegradation. This study is ...
Cobo Marién - - 2012
Multiple sclerosis (MS) is a severe debilitating disorder characterised by progressive demyelination and axonal damage of the central nervous system (CNS). Current therapies for MS inhibit the immune response and demonstrate reasonable benefits if applied during the early phase of relapsing-remitting MS (RRMS) while there are no treatments for patients ...
Schneider Susanne A - - 2012
BACKGROUND: The UPDRS is the most widely used rating scale for Parkinson's disease (PD). However, subtle features of early disease stages may be missed. METHODS: We studied 25 early PD patients using a newly compiled battery of motor tests focusing on subtle motor features. Focal dystonia patients (n = 31) ...
Goldstein Benjamin A BA Division of General Medical Disciplines, Stanford University School of Medicine, Palo Alto, CA 94304, - - 2012
One sixth of US dialysis patients 65 years of age have been diagnosed with atrial fibrillation/flutter (AF). Little is known, however, about the incidence of AF in this population. We identified 258 605 older patients (≥67 years of age) with fee-for-service Medicare initiating dialysis in 1995 to 2007, who had ...
Desai Atman - - 2012
Purpose:  Interictal positron emission tomography (PET) and ictal subtraction single photon emission computed tomography (SPECT) of the brain have been shown to be valuable tests in the presurgical evaluation of epilepsy. To determine the relative utility of these methods in the localization of seizure foci, we compared interictal PET and ...
Mattey Derek L - - 2012
ABSTRACT: INTRODUCTION: Matrix metalloproteinases (MMPs) are implicated in the destruction of the joint and have been shown to be strongly associated with inflammation in rheumatoid arthritis (RA). Circulating MMPs have also been associated with cardiovascular disease in the general population, and are predictive of cardiovascular mortality. The purpose of the ...
Priest Jacob B - - 2012
OBJECTIVES: Though research suggests support for the association between marital quality and anxiety disorders, less is known about relationship quality with relatives and friends and anxiety disorders. METHOD: Using data from the Collaborative Psychiatric Epidemiology Surveys (n = 9912; mean age 44.8; 52.2% female), the association between relationship quality with ...
El-Haibi Christelle P - - 2012
Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the ability to differentiate into multiple mesoderm lineages in the course of normal tissue homeostasis or during injury. We have previously shown that MSCs migrate to sites of tumorigenesis, where they become activated by cancer cells to promote metastasis. However, the ...
Israel Mark - - 2012
Dyck and Allen's criticisms of current systems of governance are well founded, at least in some jurisdictions. Their desire to halt the expansion and intensification of research ethics governance is to be applauded. However, their listed categories of research to be exempted from mandatory review may not create a better ...
Reise Steven P - - 2012
Confirmatory factor analytic studies of psychological measures showing item responses to be multidimensional do not provide sufficient guidance for applied work. Demonstrating that item response data are multifactorial in this way does not necessarily (a) mean that a total scale score is an inadequate indicator of the intended construct, (b) ...
O'Hern Sean C - - 2012
We report graphene composite membranes with nominal areas over 25 mm(2) fabricated by transfer of a single layer of CVD graphene onto a porous polycarbonate substrate. A combination of pressure-driven and diffusive transport measurements provides evidence of size-selective transport of molecules through the membrane, which is attributed to the low-frequency ...
Celenza Giuseppe - - 2012
The in vitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 µg mL(-1) for sphaerophorin to 1024 µg mL(-1) for ...
An S Sandy SS Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, - - 2013
Common genetic variation frequently accounts for only a modest amount of interindividual variation in quantitative traits and complex disease susceptibility. Circulating adiponectin, an adipocytokine implicated in metabolic disease, is a model for assessing the contribution of genetic and clinical factors to quantitative trait variation. The adiponectin locus, ADIPOQ, is the ...
Rana Tanmoy - - 2012
Arsenicosis caused due to drinking of arsenic contaminated ground water is a major environmental health hazard throughout the world. We evaluated the ecotoxicological effect of arsenic on chicken and duck in an arsenic endemic zone. The concentration of arsenic was higher in chicken and duck feed and their by-products than ...
Zhang Pei - - 2012
In this work, a series of novel amphiphilic dendrimers taking polyamidoamine dendrimer as the core with different hydrophobic tails QPAMCm were synthesized and the dilational properties were studied as monolayers by dilational rheological measurements at the water-air and water-n-heptane interfaces to explore the nature of adsorption behaviors. The results showed ...
Tullio Marcella Di - - 2012
Background: In this study we compared the effectiveness of Enamel Matrix Derivative (EMD) associated with a Simplified Papilla Preservation Flap (SPPF) technique to SPPF alone when surgically treating supra-alveolar-type defects Methods: 50 patients, from 54 initially selected, presenting horizontal bone loss around at least four adjacent teeth, were treated each ...
Ramos Plínio Santos - - 2012
BACKGROUND: At the maximal Cardiopulmonary Exercise Testing (CPET), several ventilatory variables are analyzed, including the ventilatory equivalent for oxygen (VE/VO2). The minimum VE/VO2 value reflects the best integration between the respiratory and cardiovascular systems and may be called "Cardiorespiratory Optimal Point (COP)". OBJECTIVE: To determine the behavior of the COP ...
Ueda Yoshihiro - - 2012
Thymocyte trafficking has an important role in thymic selection. Here we show that the Hippo homologue Mst1 is required for thymocyte migration and antigen recognition by LFA-1 and ICAM-1 within the medulla. Using two-photon imaging of thymic tissues, we found that highly motile mature thymocytes arrest and are activated in ...
De Vuyst H - - 2012
We assessed the association of human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN) with various characteristics, CD4 count and use of combination antiretroviral therapy (cART) among HIV-positive women. Cross-sectional study of 498 HIV-positive women who underwent HPV PCR-based testing, cytology, and systematic cervical biopsy. In all, 68.7% of women ...
Wong Vincent Wai-Sun - - 2012
OBJECTIVES:Liver stiffness measurement (LSM) by transient elastography is a noninvasive test of liver fibrosis, but cannot be performed in a significant proportion of obese patients. The aim of this study was to evaluate the performance of the new XL probe in patients with nonalcoholic fatty liver disease (NAFLD).METHODS:Liver biopsy and ...
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