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Pradeep A R - - 2012
Background: Atorvastatin (ATV) is a specific competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Recently, statins have shown pleiotropic effects like antiinflammation and bone stimulation. The aim of the present study was to investigate the effectiveness of 1.2 % ATV, as an adjunct to scaling and root planing (SRP) in the ...
Di Sante Domenico - - 2012
The recent discovery of high polarization at room temperature in croconic acid crystals as large as 21 μC cm(-2) [Horiuchi et al., Nature, 2010, 463, 789] has lead to renewed interest in organic ferroelectrics, a promising class of materials for future electronic devices. We present here an extended ab initio ...
Park Kyung-Ah - - 2012
Purpose: To compare retinal layer thickness and choroidal thickness profiles in preterm and full-term children using spectral domain optical coherence tomography (SD-OCT). Methods: We performed horizontal and vertical SD-OCT crosshair scans through the fovea with and without an enhanced depth technique in premature and full-term children. Retinal layer and choroidal ...
St Paul Michael - - 2012
Toll-like receptors (TLRs) play an important role in the induction of host responses to pathogens. Interactions between TLRs and their ligands result in the production of cytokines that modulate the adaptive immune response through polarizing CD4+ T cells into either T-helper (T(H))1 or T(H)2 phenotypes. In this regard, TLR2 and ...
Lillehoj Catherine J - - 2012
OBJECTIVE: To determine the status of each of the Baby-Friendly Hospital Initiative (BFHI) Ten Steps and associated policies in Iowa hospitals. DESIGN: Exploratory, descriptive study using the World Health Organization BFHI self-assessment survey. SETTING: Iowa hospitals with maternity services. PARTICIPANTS: Fifty-three Iowa hospital administrators. METHODS: Hospitals were classified by level ...
Derkach Andriy - - 2012
Many association tests have been proposed for rare variants, but the choice of a powerful test is uncertain when there is limited information on the underlying genetic model. Proposed methods use either linear statistics, which are powerful when most variants are causal and have the same direction of effect, or ...
Fung Lela - - 2012
OBJECTIVE:To report 3 cases of methicillin-resistant Staphylococcus aureus (MRSA) in pediatric patients with cystic fibrosis (CF), all of whom had inadequate serum concentrations of vancomycin with conventional intermittent dosing and who achieved therapeutic serum concentrations with continuous infusions of vancomycin.CASE SUMMARY:In the first case, a 3-year-old patient failed to achieve ...
Meynaar I A - - 2012
BACKGROUND: To study long-term survival in patients treated in the ICU and who survive to hospital discharge. METHODS:Single center retrospective cohort study of patients admitted to a mixed intensivist-led 10 bed ICU in a teaching hospital between 2004 and 2009 and discharged alive from the hospital with complete follow-up until ...
Serocki G - - 2012
BACKGROUND: Recently, indirect videolaryngoscopes have become increasingly important devices in difficult airway management. The aim of the present study was to investigate laryngoscopic view and intubation success using the new C-MAC® D-Blade in comparison to the established GlideScope® videolaryngoscope and conventional direct laryngoscopy in a randomized controlled trial. METHODS: Ninety-six ...
Müller Carola J - - 2012
A new ternary orthorhombic compound with the formula Cu(5+δ)In(2+x)Sb(2-x), crystallizing in the space group Cmc2(1) with 36 atoms per unit cell [a = 10.1813(4) Å, b = 8.4562(4) Å, c = 7.3774(2) Å, Z = 4], has been synthesized by conventional high-temperature methods. The structure is based on the B8 ...
Carrancio S - - 2012
Hematopoietic stem cell transplantation (HSCT) using umbilical cord blood (UCB) progenitors is increasingly being used. One of the problems that may arise after UCB transplantation is an impaired engraftment. Either intrabone (IB) injection of hematopoietic progenitors or mesenchymal stem cells (MSCs) co-administration have been proposed among the strategies to improve ...
Zhao Min - - 2012
Ovarian cancer is the leading cause of death in gynecological cancer. Studies suggested Rab25 is involved in the pathogenesis of ovarian cancers. We here investigated the expression of Rab25 is in all ovarian cancers and whether the expression of Rab25 is associated with peritoneal metastasis. Fifty-nine ovarian cancer patients were ...
George Subi Jacob - - 2012
Stereoselective non-covalent synthesis of one-dimensional helical self-assembled stacks of achiral oligo(p-phenylenevinylene) ureidotriazine (AOPV3) monomers is obtained by a chiral supramolecular auxiliary approach. The racemic mixture of helical stacks of achiral AOPV3 molecules is converted into homochiral helical stacks, as shown by both spectroscopic measurements and molecular modeling simulations. The conversion ...
Karimi Mohammad - - 2012
Background: Scottish-Rite orthosis is one of the conservative methods used to treat Legg-Calvé-Perthes disease. As there was not enough evidence to show the effects of using this orthosis on reducing the loads applied on the limb, this research aimed to find the influence of this orthosis.Case Description and Methods: A ...
Yasumizu Yota - - 2012
【Objectives】 Lymphocele development is the most frequently reported postoperative complication of pelvic lymph node dissection (PLND) performed with laparoscopic radical prostatectomy (LRP). This study evaluated the efficacy of a vessel sealing device (VSD) for the prevention of lymphocele development. 【Methods】 A total of 120 patients who underwent LRP with PLND ...
Blot F - - 2012
Acute respiratory failure (ARF) is frequent and often fatal in patients with a malignancy. However, there is not one type of "oncology patient", and it's high time that both clinical management and further studies consider specific populations rather than the heterogeneous and artificial group of "cancer patients". This individual-based approach ...
Kawabata Kohsuke - - 2012
Electrochemical polymerization of a series of N-alkyl-2,7-di(2-thienyl)carbazoles in acetonitrile was performed to obtain conjugated polymers with fluorescence. Scanning electron and atomic force microscopies revealed that the surface morphology of the polymer films significantly depends on the alkyl chain lengths of the polymers. Particularly, a homopolymer bearing hexyl groups and copolymers ...
Sabbatini Paul J - - 2012
PURPOSE: Long peptides are efficiently presented to both CD4+ and CD8+ T-cells after intracellular processing by antigen presenting cells. To investigate the safety and in vivo immunogenicity of synthetic overlapping long peptides (OLP) from a human tumor self-antigen, we conducted a phase I clinical trial with OLP from cancer-testis antigen ...
Duran-Prado Mario - - 2012
Somatostatin (SST) and its related peptide cortistatin (CORT) exert their multiple actions through binding to the SST receptor (sst) family, generally considered to comprise five G-protein coupled receptors (GPCRs) with 7 transmembrane domains (TMD), named sst1-sst5, plus a splice sst2B variant. However, we recently discovered that human and rodent sst5 ...
Chatterjee Sarmishtha - - 2012
In the present study, we attempted to elucidate the induction of autophagy in rat hepatocytes by a low concentration of mercury. Hepatocytes treated with different doses of mercuric chloride (HgCl(2); 1, 2.5, 5 and 10 µM) and at different time intervals (0 min, 30 min, 1 h, 2 h and ...
Boyce Richard D - - 2012
BACKGROUND:Food and Drug Administration (FDA) regulations mandate that package inserts (PIs) include observed or predicted clinically significant drug-drug interactions (DDIs), as well as the RESULTS: To quantify how frequently observed metabolic inhibition DDIs affecting US-marketed psychotropics are present in FDA-approved PIs and what influence the source of DDI information has ...
Veronesi Francesca - - 2012
Mesenchymal stem cells (MSCs) from bone marrow (BM) are widely used for bone and less for cartilage tissue regeneration due to their self-renewal and differentiating properties into osteogenic or chondrogenic lineages. This review considers the last decade of clinical trials involving a two-step procedure, by expanding in vitro MSCs from ...
Yang Hua-Feng - - 2012
The structures and catalytic properties of AuPd clusters supported on carbon nanotubes (CNTs) for H(2)O(2) synthesis have been investigated by means of density functional theory calculations. Firstly, the structures of AuPd clusters are strongly influenced by CNTs, in which the bottom layers are mainly composed of Pd and the top ...
Wang Mo - - 2012
In this paper, we developed a novel electrochemical method to quantify DNA methyltransferase (MTase) and analyze DNA MTase activity. After the double DNA helix structure was assembled on the surface of gold nanoparticals modified glassy carbon electrode, it was first methylated by M. SssI MTase, then digested by restriction endonuclease ...
Repp Kristin L - - 2012
BACKGROUND:Drug-related problems (DRPs) in the general population account for 15% of all hospital admissions, of which approximately 30% are preventable. Cardiac transplant patients may be at increased risk for DRPs because of their complicated medication regimens that include drugs with a narrow therapeutic index.OBJECTIVE:To determine the incidence and preventability of ...
Florence Gordon J - - 2012
A stereoselective synthesis of the proposed structure of palmerolide C (1), a cytotoxic marine macrolide isolated from the Antarctic tunicate Synoicum adareanum, utilizes a convergent carbonyl-based coupling strategy to construct the C1-C24 carbon skeleton. Compound 1 was shown to be a diastereomer of palmerolide C, and the structural revision of the natural ...
Wang H - - 2012
Forming a good Ge/dielectric interface is important to improve the electron mobility of a Ge metal oxide semiconductor field-effect transistor. A thin yttrium germanate capping layer can improve the properties of the Ge/GeO(2) system. We employ electronic structure calculations to investigate the effect of oxygen vacancies in yttrium-doped GeO(2) and ...
Bosman Peter A N - - 2012
Abstract We describe a parameter-free Estimation-of-Distribution Algorithm (EDA) named Adapted Maximum-Likelihood Gaussian Model Iterated Density-Estimation Evolutionary Algorithm (AMaLGaM-IDEA, or AMaLGaM for short) for numerical optimization. AMaLGaM is benchmarked within the 2009 Black-Box Optimization Benchmarking (BBOB) framework and compared to a variant with incremental model building (iAMaLGaM). We study the implications ...
Vereecken L - - 2012
The reaction of Criegee intermediates (CI) with NO and RO(2) radicals is studied for the first time by theoretical methodologies; additionally, the reaction of CI with SO(2) molecules is re-examined. The reaction of CI with NO was found to be slow, with a distinct energy barrier. Their reaction with RO(2) ...
Mosley Garrett L - - 2012
Vesicles represent an important class of nanoscale drug delivery vehicles. To significantly reduce the time and resources that are required to optimize these drug carriers, this review article discusses the mathematical models that have been derived for understanding the formation of vesicles and their stability, as well as for predicting ...
Ueda Yoshihiro - - 2012
Thymocyte trafficking has an important role in thymic selection. Here we show that the Hippo homologue Mst1 is required for thymocyte migration and antigen recognition by LFA-1 and ICAM-1 within the medulla. Using two-photon imaging of thymic tissues, we found that highly motile mature thymocytes arrest and are activated in ...
Wong Vincent Wai-Sun - - 2012
OBJECTIVES:Liver stiffness measurement (LSM) by transient elastography is a noninvasive test of liver fibrosis, but cannot be performed in a significant proportion of obese patients. The aim of this study was to evaluate the performance of the new XL probe in patients with nonalcoholic fatty liver disease (NAFLD).METHODS:Liver biopsy and ...
Li Jun - - 2012
The catalytic enantioselective fluorination of N-H-free 3-substituted oxindoles was accomplished by Sc(III)/N,N'-dioxide complex. Under mild reaction conditions, a series of 3-aryl- and 3-alkyl-3-fluoro-2-oxindoles were obtained in excellent yields (up to 98%) and enantioselectivities (up to 99% ee) by using N-fluorobisbenzenesulphonimide (NFSI) as the fluorination agent. MaxiPost was synthesized efficiently in ...
Messmer Andreas T - - 2012
Determining the structure of reactive intermediates is the key to understanding reaction mechanisms. To access these structures, a method combining structural sensitivity and high time resolution is required. Here ultrafast polarization-dependent two-dimensional infrared (P2D-IR) spectroscopy is shown to be an excellent complement to commonly used methods such as one-dimensional IR ...
Patel Dipam - - 2012
A series of peptidomimetics containing bidentate pTyr mimetics (9a-w) are reported as potent and selective PTP1B inhibitors. Compounds (9p and 9q) showed excellent selectivity towards PTP1B over various PTPs, including TCPTP (in vitro), confirms discovery of highly potent and selective PTP1B inhibitors.
Tamada Koji - - 2012
PURPOSE: To develop an adaptable gene-based vector that will confer immune cells specificity to various cancer types. EXPERIMENTAL DESIGN: Human and mouse T cells were genetically engineered to express a chimeric antigen receptor (CAR) that binds a fluorescein isothiocyanate (FITC) molecule, termed anti-FITC CAR T cells. Various antibodies (Abs) currently ...
Nonoo Rebecca H - - 2012
Birds of a tether: A tethering strategy for the site-directed discovery of low-molecular-weight fragments that bind weakly to defined protein surfaces is described. A solvent-exposed protein thiol captures acrylamide-modified fragments in a conjugate addition reaction that requires a template to produce a measureable quantity of protein-fragment adduct, which can be ...
Ezekowitz Justin A - - 2012
BACKGROUND: -Randomized controlled trials (RCT) are limited by their generalizability to the broader non-trial population. In order to provide a context for the Acute Study of Nesiritide in Decompensated Heart Failure (ASCEND-HF) trial, we designed a complementary registry to characterize clinical characteristics, practice patterns, and in-hospital outcomes of acute heart ...
Schultz Douglas S - - 2012
To determine the effects of reading the Wikipedia article on the Rorschach on Comprehensive System variables, participants in this study (recruited from parent-teacher associations, online message boards, and graduate schools; N = 50) were provided with either a copy of the Wikipedia article on the Rorschach (from April 2010) or ...
Jin Yu - - 2012
Colonic administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced acute colitis in mice and elicited a Th1 immune response. Th17 cells are believed to play a major role in TNBS-induced colitis. The aim of this study is to investigate the roles of interleukin (IL)-17 and interferon (IFN)-γ in the pathogenesis of ...
Baklouti-Gargouri Siwar - - 2012
Cytochrome c oxidase encoded by multiple mitochondrial genes (COXI, COXII, and COXIII) and nuclear genes is an essential component of the mitochondrial respiratory chain that catalyzes the reduction of molecular oxygen by reduced cytochrome c. Subunits COXI and COXII of cytochrome c oxidase are known to play the most essential ...
Engmann Sarah - - 2012
Relative cross sections for dissociative electron attachment (DEA) and dissociative ionization (DI) of the FEBID precursor, trimethyl (methylcyclopentadienyl) platinum(iv), MeCpPtMe(3), are presented. The most pronounced DEA process is the loss of one methyl radical, while the loss of two or three methyl groups along with hydrogen is the main pathway ...
Anand Sushant - - 2012
Nanotextured superhydrophobic surfaces have received significant attention due to their ability to easily shed liquid drops. However, water droplets have been shown to condense within the textures of superhydrophobic surfaces, impale the vapor pockets, and strongly pin to the surface. This results in poor droplet mobility and degrades condensation performance. ...
Luria Justin L - - 2012
We present spatially-resolved photovoltage spectra of a bulk heterojunction solar cell film comprised of phase-separated poly(9,9`-dioctylfluorene-co-benzo-thiadiazole) (F8BT) and poly(9,9`-dioctylfluorene-co-bis-N,N`-(4-butylphenyl)-bis-N,N`-phenyl-1,4-phenylene-diamine) (PFB) polymers prepared on ITO/PEDOT:PSS and aluminum substrates. Over both PFB- and F8BT-rich domains the photopotential spectra were found to be proportional to a linear combination of the polymers' absorption spectra. ...
Carlson Misty - - 2012
BACKGROUND: Girls and women with Turner syndrome are at risk for aortic dissection and rupture. However the size of the aorta and the clinical characteristics among those with Turner syndrome and dissection has received little attention. METHODS AND RESULTS: We obtained medical records from 20 individuals who voluntarily participated in ...
Mattei Tobias A - - 2012
Object Bicycle accidents are a very important cause of clinically important traumatic brain injury (TBI) in children. One factor that has been shown to mitigate the severity of lesions associated with TBI in such scenarios is the proper use of a helmet. The object of this study was to test ...
Bi Yingpu - - 2012
Two-dimensional dendritic Ag(3)PO(4) nanostructures have been synthesized in high-yield by reacting Ag nanowires with H(2)O(2) and NaH(2)PO(4) in aqueous solution at room temperature, which exhibit much higher photocatalytic activities than irregular Ag(3)PO(4) nanocrystals and N-doped TiO(2) catalyst for the degradation of organic contaminants under visible light irradiation.
Karolina Dwi Setyowati - - 2012
Context:Coordinated interplay of dysregulated microRNAs in isolated metabolic disorder is implicated in the pathogenesis of metabolic syndrome.Objective:The objective of the study was to characterize microRNA expression in the blood and exosomes of individuals with metabolic syndrome and compare them with those manifesting one of the metabolic vascular risk factors (type ...
Nicolini A - - 2012
The use of non-invasive ventilation (NIV) in acute hypoxemic respiratory failure (AHRF) due to H1N1 virus infection is controversial. In this multicenter study we aimed to assess the efficacy of NIV in avoiding endotracheal intubation (ETI) and to identify predictors of success or failure. In this prospective multicenter study, 98 ...
Khemees Tariq A - - 2012
Background and Purpose: Numerous holmium:YAG laser fibers are available for flexible ureteroscopy. Fibers performance and durability can vary widely amongst different manufacturers and their product lines with differences within a single product line have been reported. We sought to evaluate a newly developed non-tapered, single-use 240 µm fiber, Flexiva™ 200 ...
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