Search Results
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Farmer Caroline S - - 2012
ABSTRACT: BACKGROUND: There is a significant treatment gap for patients with depression. A third of sufferers never seek help, and the vast majority of those who do only do so after considerable delay. Little is understood regarding poor help-seeking rates amongst people with depression, with existing research mainly focussed on ...
Pawar Amit B - - 2012
A formal total synthesis of the 20-membered marine macrolide, palmerolide A from chiral pool tartaric acid is described. Elaboration of a γ-hydroxy amide, which is derived from the desymmetrization of tartaric acid amide, and Boord olefination are the pivotal reactions employed for the synthesis of the chiral building blocks, and Stille ...
Díaz-de-Villegas María D - - 2012
Desymmetrization of diols is a powerful tool to the synthesis of chiral building blocks. Among the different approaches to perform discrimination between both enantiotopic hydroxyl groups, the organocatalytic approach has gained importance in the last years. A diverse range of organocatalysts has been used to efficiently promote this enantioselective transformation ...
Lovell Rebecca M - - 2012
OBJECTIVES:Irritable bowel syndrome (IBS) and gastro-esophageal reflux-type symptoms (GERS) are highly prevalent in the general population, and the two appear to be related. We conducted a systematic review and meta-analysis to estimate the prevalence of GERS in individuals with IBS, and to quantify the overlap between the two disorders.METHODS:MEDLINE, EMBASE, ...
Fernández-Del-Olmo Miguel - - 2012
BACKGROUND: Auditory external cues enhance step initiation in Parkinson's disease (PD) patients. We wanted to explore whether a startle reaction has a comparable effect on step initiation in PD. METHODS: Thirteen PD patients and 13 aged-matched controls participated in this study. Electromyography pattern and onset toe-off time during a step ...
Lash Timothy David - - 2012
Tripyrranes with tert-butyl and phenyl substituents have been prepared and used to synthesize oxybenziporphyrins, oxypyriporphyrins, benzocarbaporphyrins and azuliporphyrins with phenyl and tert-butyl substituents via a "3 + 1" methodology. The proton NMR spectra for the tripyrrane dibenzyl esters indicate that these tripyrrolic systems take on a helical conformation that favors ...
Li Peng-Fei - - 2012
Starting from triptycene, 2-, (2,6- or 2,7-)di-, and (2,6,14- or 2,7,14-)tri-formyl or acetyl substituted triptycenes were selectively synthesized. The derivatization of the formyl or acetyl substituted triptycenes was then investigated. Consequently, it was found that the formyl-substituted triptycenes could be transformed into cyano substituted triptycene derivatives by the aldoxime formation ...
Imai Satoki - - 2012
Organic anion transporting polypeptides (rodents, Oatps; human, OATPs) are primarily involved in the transmembrane transport of a wide range of endogenous and exogenous compounds. Multiple mouse Oatp1 isoforms are closely located on chromosome 6 where each isoform shows distinct tissue distribution; Oatp1b2, Oatp1a6 and Oatp1c1 are expressed exclusively in the ...
He Jianwei - - 2012
Chicken cystatin (cC) mutant I66Q is located in the hydrophobic core of the protein and increases the propensity for amyloid formation. Here, we demonstrate that under physiological conditions, the replacement of Ile with the Gln in the I66Q mutant increases the susceptibility for the disulfide bond Cys71-Cys81 to be reduced ...
Conejero Salvador - - 2012
Unsaturated [Tp(Me2)Ir(iii)] fragments, readily generated from compounds [Tp(Me2)Ir(C(6)H(5))(2)(N(2))], () and [Tp(Me2)Ir(η(4)-CH(2)[double bond, length as m-dash]C(Me)C(Me)[double bond, length as m-dash]CH(2)] () (Tp(Me2) = hydrotris(3,5-dimethylpyrazolyl)borate), induce the isomerisation of the polypyridines, 2,2'-bipyridine, 1,10-phenanthroline and 2,2':6'2''-terpyridine, to form complexes that contain the carbene tautomer of these ligands. For terpy, a binuclear compound has ...
Polak David - - 2012
Background: Periodontitis is a polymicrobial infectious disease. A novel potential chemical treatment modality may lie in bacterial anti-adhesive materials, such as cranberry juice fractions. The aim of this study was to explore the effect of high molecular weight cranberry constituent (NDM - non-dialysable material) on the virulence of a mixed ...
Lakadamyali Fezile - - 2012
A visible-light driven H(2) evolution system comprising of a Ru(II) dye (RuP) and Co(III) proton reduction catalysts (CoP) immobilised on TiO(2) nanoparticles and mesoporous films is presented. The heterogeneous system evolves H(2) efficiently during visible-light irradiation in a pH-neutral aqueous solution at 25 °C in the presence of a hole scavenger. ...
Satpati Ashis Kumar - - 2012
We report a simple method of preparation of carbon paste ultramicroelectrodes (UMEs) for use as probe tips in scanning electrochemical microscopy (SECM). Carbon paste UMEs were prepared by packing the carbon paste into a chemically etched tip of a Pt-UME or a pulled glass capillary. Carbon based UMEs are attractive ...
Swijsen Ann - - 2012
Purpose:  Febrile seizures (FS), the most frequent seizure type during childhood, have been linked to temporal lobe epilepsy (TLE) in adulthood. Yet, underlying mechanisms are still largely unknown. Altered γ-aminobutyric acid (GABA)ergic neurotransmission in the dentate gyrus (DG) circuit has been hypothesized to be involved. This study aims at analyzing ...
Tan Yonggang - - 2012
The aim of this work was to evaluate the influence of protein-bound polysaccharide Kureha(PSK) on murine dendritic cells (DCs). These impacts of PSK on DCs from bone marrow derived DCs(BMDCs) were assessed with inverted phase contrast microscope, conventional scanning electron microscopy (SEM), transmission electron microscopy (TEM) for morphology, fluorescence activated ...
Knobloch Karsten - - 2012
ABSTRACT: BACKGROUND: Plantar fibromatosis is a benign disease creating nodules on the medial plantar side of affected patients. While surgical removal is regarded as the therapeutic mainstay, recurrence rates and impairment of daily activities remains substantial. High-energy focussed extracorporeal shockwave therapy has been suggested to be potentially effective in plantar ...
Olmstead Spencer B - - 2012
We conducted a qualitative content analysis of written responses from 148 college men to questions about pregnancy resolution and marriage in the event of an unplanned pregnancy. We used Marsiglio's ( 1991 ) concepts of procreative consciousness and responsibility as a source of theoretical sensitivity during data analysis. Men's written ...
Bailarote Bruno Cachapa - - 2012
• Premise of the study: Orchids rely on mycorrhizal fungi for seed germination, and many species maintain associations during later stages in their life cycle. Because of the critical dependence of orchids on fungi it has been suggested that the degree of mycorrhizal specificity may be associated with rarity and ...
Röhlich Christoph - - 2012
Many reports on water-compatible palladium catalysts have appeared in the recent literature. For hydrophobic substrates, mixtures with pure water are biphasic, and it is widely not regarded that the elusive locality of the catalytic process (in water, the organic layer, or at the phase boundary) has an important impact on ...
Baliga Manjeshwar S - - 2012
Abstract Background: In spite of the tremendous progress achieved in medical sciences in the last century, the management of diabetes mellitus, a disease as old as mankind, is poor. Diabetes is currently the world's largest endocrine disorder, and estimates are that it affects almost 5% of the population. Ayurveda, the ...
Arantes Ferreira Peres Wilza - - 2012
Hepatic vitamin A stores should be the best early indicator of vitamin A status because more than 90% of total body vitamin A is stored in the liver. The objective of the present study was to evaluate the hepatic vitamin A stores in all stages of chronic liver disease (CLD), ...
Smith Leah - - 2012
Abstract Background: Approximately 20% of deaths in the United States occur in the intensive care unit (ICU). Physician trainees lack the practical communication skills required for end-of-life care, including establishing patient preferences, participating in shared decision making, discussing prognosis, and delivering bad news. Utilizing facilitated, case-based, peer interactions, we sought ...
de Bot Susanne T - - 2012
Although the combined presence of ataxia and pyramidal features has a long differential, the presence of a true spastic-ataxia as the predominant clinical syndrome has a rather limited differential diagnosis. Autosomal recessive ataxia of Charlevoix-Saguenay, late-onset Friedreich ataxia, and hereditary spastic paraplegia type 7 are examples of genetic diseases with ...
Hasanayn Faraj - - 2012
The potential energy surface (PES) of H(2) addition to the Ru═N bond of a model five-coordinate ruthenium amide (Ru═N), leading to an octahedral trans-Ru(H)(2)(diamine)(diphosphine) (HRu-NH) and subsequent acetophenone hydrogenation, is studied using M06 density functional theory methods. A qualitative molecular orbital analysis reveals that H(2) addition to the ground state ...
Sung Yu-Hsiang - - 2012
Ohmic contact formation at the interface of the Au nanoparticle (NP)-ZnO nanosheet (NS), which facilitates photoelectron transfer from ZnO NSs to Au NPs, is determined by scanning Kelvin microscopy for the first time. Reduction of charge recombination in the ZnO NSs confirmed by the quench of green band emission results ...
Liva Sarah J - - 2012
OBJECTIVE: To test whether demographic characteristics predict registered nurses' attitudes toward birth practices. DESIGN: A secondary analysis of a cross-sectional survey, the National Maternity Care Attitudes Survey. SETTING: A national survey conducted with health care providers providing maternity care in Canada. PARTICIPANTS: A convenience sample of 545 registered nurses. METHODS: ...
Jakes Peter - - 2012
The electrocatalytical process at the air cathode in novel silicon-air batteries using the room-temperature ionic liquid hydrophilic 1-ethyl-3-methylimidazolium oligofluorohydrogenate [EMI⋅2.3 HF⋅F] as electrolyte and highly doped silicon wafers as anodes is investigated by electrochemical means, X-ray photoelectron spectroscopy (XPS), and electron paramagnetic resonance (EPR) spectroscopy. The results obtained by XPS ...
Kowalski Damian - - 2012
In and out of tube: Robust poly-3,4-ethylene-dioxythiophene nanostructures in the form of nanopore arrays and inverse nanotube arrays are obtained by site-selective deposition into TiO(2) nanotubes. The deposition process critically depends on the applied potential and is in line with three-dimensional (3D) progressive and 3D instantaneous nucleation-growth mechanism, leading to ...
Mammen Lena - - 2012
The effect of nanoroughness on contact angles and pinning is investigated experimentally and numerically for low energy surfaces. Nanoroughness can improve or impair the liquid repellency of superhydrophobic surfaces, which were made from assembled raspberry particles. In the studied system nanoroughness is introduced by chemical vapor deposition of tetraethoxysilane and ...
Parolo Claudio - - 2012
In this review we discuss how nanomaterials can be integrated in diagnostic paper-based biosensors for the detection of proteins, nucleic acids and cells. In particular first the different types and properties of paper-based nanobiosensors and nanomaterials are briefly explained. Then several examples of their application in diagnostics of several biomarkers ...
Mednick Lauren - - 2012
Objective :  To describe and compare the causal beliefs associated with cleft lips and/or palates across several different countries. Design :  Cross-sectional survey. Setting :  Operation Smile surgery screenings in six developing countries. Participants :  Two hundred seventy-nine adult patients and parents of children with cleft lips and/or palates in ...
Smulders Maarten M J - - 2012
Over the last two decades the field of metallosupramolecular self-assembly has emerged as a promising research area for the development of intricate, three-dimensional structures of increasing complexity and functionality. The advent of this area of research has strongly benefited from design principles that considered the ligand geometry and metal coordination ...
Eden Alvin N - - 2012
Iron deficiency anemia (IDA) continues to be overwhelmingly the leading cause of anemia in early childhood and a global public health challenge. Although there has been a significant decrease in the frequency of IDA and iron deficiency (ID) in infants and toddlers in recent years in the United States, ID ...
Forehand Christy C - - 2012
OBJECTIVE:To evaluate whether there is a relationship between antimicrobial therapy and the development of thrombocytosis.DATA SOURCES:Literature was accessed through EMBASE (1977-June 2012) and MEDLINE (1977-June 2012) using the terms thrombocytosis and antimicrobial. In addition, reference citations from publications identified were reviewed.STUDY SELECTION AND DATA EXTRACTION:All English-language publications identified were evaluated. ...
West Patrick J - - 2012
The syntheses of trans-[Os(C≡C-4-C(6)H(4)X)Cl(dppe)(2)] [X = Br (3), I (4)], trans-[Os(C≡C-4-C(6)H(4)X)(NH(3))(dppe)(2)](PF(6)) [X = H (5(PF(6))), I (6(PF(6)))], and trans-[Os(C≡C-4-C(6)H(4)X)(C≡C-4-C(6)H(4)Y)(dppe)(2)] [X = Y = H (7), X = I, Y = C≡CSiPr(i)(3) (8)] are reported, together with improved syntheses of cis-[OsCl(2)(dppe)(2)] (cis-1), trans-[Os(C≡CPh)Cl(dppe)(2)] (2), and trans-[Ru(C≡C-4-C(6)H(4)I)(NH(3))(dppe)(2)](PF(6)) (9(PF(6))) (the last-mentioned direct from ...
Lejeune Julien - - 2012
The FCGR3A-V158F and FCGR2A-H131R polymorphisms are associated with clinical responses to therapeutic mAbs and with immune thrombocytopenic purpura (ITP). The FCGR2C-ORF/STOP polymorphism, controlling FcγRIIC expression on natural killer cells and therefore FcγRIIC-mediated antibody dependent cell-mediated cytotoxicity, is also associated with ITP. Using a new pyrosequencing assay to determine this polymorphism ...
Meredith Nathan A - - 2012
The incorporation of neptunium(VI) into the layered uranyl selenite Cs[(UO(2))(HSeO(3))(SeO(3))] has yielded the highest level of neptunium uptake in a uranyl compound to date with an average of 12(±3)% substitution of Np(VI) for U(VI). Furthermore, this is the first case in nearly 2 decades of dedicated incorporation studies in which ...
Sylvester Kevin T - - 2012
The mechanism of a recently reported Suzuki coupling reaction of quinoline-derived allylic N,O-acetals has been studied using a combination of structural, stereochemical, and kinetic isotope effect experiments. The data indicate that C-O activation is facilitated by Lewis acid assistance from the boronic acid coupling partner and an ionic SN1-like mecha-nism ...
Cortese Michael J - - 2012
Imageability and age of acquisition (AoA) effects, as well as key interactions between these variables and frequency and consistency, were examined via multiple regression analyses for 1,936 disyllabic words, using reaction time and accuracy measures from the English Lexicon Project. Both imageability and AoA accounted for unique variance in lexical ...
Mullins Elwood Arthur - - 2012
CoA-transferases catalyze transthioesterification reactions involving acyl-CoA substrates, using an active-site carboxylate to form covalent acyl anhydride and CoA-thioester adducts. Mechanistic studies of class I CoA-transferases suggested that acyl-CoA binding energy is used to accelerate rate-limiting acyl transfers by compressing the substrate thioester tightly against the catalytic glutamate [White, H., and ...
Bogaerts A F L - - 2012
Objective:Lifestyle intervention could help obese pregnant women to limit their weight gain during pregnancy and improve their psychological comfort, but has not yet been evaluated in randomized controlled trials. We evaluated whether a targeted antenatal lifestyle intervention programme for obese pregnant women influences gestational weight gain (GWG) and levels of ...
Moon Ji Sook - - 2012
Stem cell-based cell replacement of lost midbrain dopamine (mDA) neurons is a potential therapy for Parkinson's disease (PD). Toward this goal, it is critical to optimize various aspects of cell transplantation and to assess functional recovery through behavioral tests in validated animal model(s) of PD. At present, cell transplantation studies ...
Budroni M A - - 2012
A reaction-diffusion-convection (RDC) model is introduced to analyze convective dynamics around horizontally traveling fronts due to combined buoyancy- and surface tension-driven flows in vertical solution layers open to the air. This isothermal model provides a means for a comparative study of the two effects via tuning two key parameters: the ...
Shin Ji-Hyeon - - 2012
ObjectivesThe purpose of the present study was to investigate the effect of nucleotide-binding oligomerization domain 1 (NOD1), an innate immune sensor, on allergic inflammation and induction of regulatory T cells in a mouse model of allergic rhinitis. We also aimed to explore whether there were differences in the effect of ...
Xiang Zheng - - 2012
Two new saponins were isolated from the leaves of Panax quinquefolium and their structures were elucidated as 3β, 6α, 20S-trihydroxy-12β, 23R-epoxydammar-24-ene 6-O-[α-L-rhamnosyl(1 → 2)-β-D-glucopyranosyl]-20-O-β-D-glucopyranoside (1) and 3β, 20S-dihydroxy-12β, 23R-epoxydammar-24-ene 3-O-[β-D-glucopyranosyl(1 → 2)-β-D-glucopyranosyl]-20-O-β-D-glucopyranoside (2) on the basis of physicochemical evidence.
Joosten Antoine - - 2012
A highly selective oxidative palladium(II)-catalyzed (Wacker-type) cyclization of readily available allylic tosylcarbamates is reported. This operationally simple catalytic reaction furnishes tosyl-protected vinyl-oxazolidinones, common precursors to syn-1,2-amino alcohols, in high yield and excellent diasteroselectivity (>20:1). It is demonstrated that both stoichiometric amounts of benzoquinone (BQ) as well as aerobic reoxidation (molecular ...
Bouma Marinus J - - 2012
I: hyperfond of a triple bond! The first one-pot synthesis of alkynyl(aryl)iodonium salts directly from aryl iodides has been developed. The reaction is fast and high yielding, and can be extended to the synthesis of alkynyl benziodoxolones. The developed methodology is expected to greatly facilitate the access to this interesting ...
Sun Li - - 2012
HIV-1 integrase strand transfer inhibitors are an important class of compounds targeted for the treatment of HIV-1 infection. Microdosing has emerged as an attractive tool to assist in drug candidate screening for clinical development, but necessitates extremely sensitive bioanalytical assays, typically in the pg/mL concentration range. Currently, accelerator mass spectrometry ...
Min Jeff - - 2012
Purpose: To compare the anti-fibrotic effects of single versus multiple postoperative injections of saratin following glaucoma filtration surgery (GFS) in the rabbit model. Methods: The experiment was in two parts. To determine the optimal frequency for postoperative therapy, seven New Zealand White (NZW) rabbits received an injection of saratin under ...
Yang Xing - - 2012
In contrast to alcohols and amines, racemic lactams and thiolactams cannot be resolved directly via enzymatic acyla-tion or classical resolution. Asymmetric N-acylation promoted by amidine-based catalysts, particularly Cl-PIQ 2 and BTM 3, provides a convenient method for the kinetic resolution of these valuable compounds, and often achieves excellent levels of ...
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