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Vesikari Timo T Vaccine Research Center; University of Tampere, Tampere, Finland. - - 2012
Incidence of meningococcal diseases is high in children, and effective vaccines are needed for this age group. In this phase II, open, controlled study, 309 children aged 2-10 y from Finland were randomized (3:1) into two parallel groups to receive one dose of meningococcal ACWY-tetanus toxoid conjugate vaccine (ACWY-TT group; ...
Lakadamyali Fezile - - 2012
A visible-light driven H(2) evolution system comprising of a Ru(II) dye (RuP) and Co(III) proton reduction catalysts (CoP) immobilised on TiO(2) nanoparticles and mesoporous films is presented. The heterogeneous system evolves H(2) efficiently during visible-light irradiation in a pH-neutral aqueous solution at 25 °C in the presence of a hole scavenger. ...
Steffen Annika A Department of Epidemiology, German Institute of Human Nutrition-DIfE-Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. - - 2012
Evidence from prospective studies on intake of meat and fish and risk of squamous cell carcinoma (SCC) of the upper aero-digestive tract (UADT) is scarce. We prospectively investigated the association of meat and fish intake with risk of SCC of the UADT and the possible mechanism via heme iron in ...
Satpati Ashis Kumar - - 2012
We report a simple method of preparation of carbon paste ultramicroelectrodes (UMEs) for use as probe tips in scanning electrochemical microscopy (SECM). Carbon paste UMEs were prepared by packing the carbon paste into a chemically etched tip of a Pt-UME or a pulled glass capillary. Carbon based UMEs are attractive ...
Swijsen Ann - - 2012
Purpose:  Febrile seizures (FS), the most frequent seizure type during childhood, have been linked to temporal lobe epilepsy (TLE) in adulthood. Yet, underlying mechanisms are still largely unknown. Altered γ-aminobutyric acid (GABA)ergic neurotransmission in the dentate gyrus (DG) circuit has been hypothesized to be involved. This study aims at analyzing ...
Tan Yonggang Y Department of Oncology; Shengjing Hospital; China Medical University; Shenyang, P.R. - - 2012
The aim of this work was to evaluate the influence of protein-bound polysaccharide Kureha(PSK) on murine dendritic cells (DCs). These impacts of PSK on DCs from bone marrow derived DCs(BMDCs) were assessed with inverted phase contrast microscope, conventional scanning electron microscopy (SEM), transmission electron microscopy (TEM) for morphology, fluorescence activated ...
Hill-Burns E M - - 2012
Prior studies have established an inverse association between cigarette smoking and the risk of developing Parkinson's disease (PD), and currently, the disease-modifying potential of the nicotine patch is being tested in clinical trials. To identify genes that interact with the effect of smoking/nicotine, we conducted genome-wide interaction studies in humans ...
Poulos Thomas L TL Departments of Molecular Biology & Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine, Irvine, California 92697-3900, United States. - - 2013
Nitric oxide synthase (NOS) converts l-arginine into l-citrulline and releases the important signaling molecule nitric oxide (NO). In the cardiovascular system, NO produced by endothelial NOS (eNOS) relaxes smooth muscle which controls vascular tone and blood pressure. Neuronal NOS (nNOS) produces NO in the brain, where it influences a variety ...
List Thomas - - 2012
Bispecific antibodies are proteins that bind two different antigens and may retarget immune cells with a binding moiety specific for a leukocyte marker. A binding event in blood could in principle prevent antibody extravasation and accumulation at the site of disease. In this study, we produced and characterized two tetravalent ...
Eriksson T M - - 2012
Cognitive impairments are common in depression and involve dysfunctional serotonin neurotransmission. The 5-HT(1B) receptor (5-HT(1B)R) regulates serotonin transmission, via presynaptic receptors, but can also affect transmitter release at heterosynaptic sites. This study aimed at investigating the roles of the 5-HT(1B)R, and its adapter protein p11, in emotional memory and object ...
Nazzi Vittoria - - 2012
This paper reports the case of a patient presenting motor and sensitive deficits of the left forearm and hand after a traumatic injury of the median, ulnar, and radial nerves. Decompression and neurolysis of the three nerves was performed. Spontaneous electromyographic activity and the amplitude of compound muscle action potentials ...
Hiraoka Sakiko - - 2012
BACKGROUND:Calcineurin inhibitors (CNIs) such as cyclosporine and tacrolimus have been shown to be effective for treatment of patients with steroid-dependent or steroid-refractory ulcerative colitis (UC) with moderate to severe activity. However, it has not been determined whether readministration of CNIs is effective in patients who experience relapse after remission induced ...
Filibian Marta - - 2012
Purpose:  Long-lasting activation of glia occurs in brain during epileptogenesis, which develops after various central nervous system (CNS) injuries. Glia is the cell source of the biosynthesis and release of molecules that play a role in seizure recurrence and may contribute to epileptogenesis, thus representing a putative biomarker of epilepsy ...
Lampert Zach Evan - - 2012
We report the results of a detailed investigation that addresses the influence of polymer morphology and chain aggregation, as controlled by the chemical nature of the solvent, on the optical gain properties of the conjugated polymer poly[2-methoxy-5-(2'-ethylhexyloxy)-p-phenylene vinylene] (MEH-PPV). Using the variable stripe length technique in the picosecond regime, we ...
Xie Zhihong Z Department of Oral Health and Diagnostic Sciences, Division of Periodontology, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030-1710, - - 2012
Neutrophils are found within Candida albicans biofilms in vivo and could play a crucial role in clearing the pathogen from biofilms forming on catheters and mucosal surfaces. Our goal was to compare the antimicrobial activity of neutrophils against developing and mature C. albicans biofilms and identify biofilm-specific properties mediating resistance ...
Eisenberger Patrick - - 2012
Discrete 3-coordinate borenium salts 1c and 1d are accessed by cooperative Lewis acid/base pair-mediated heterolytic splitting of the B-H bond in pinacolborane by B(C6F5)3•DABCO or Ph3C+/DABCO, respectively. The resulting salts are competent catalysts in the reduction of a broad range of imines and can be generated in-situ. Moreover, a mechanistic ...
Knobloch Karsten - - 2012
ABSTRACT: BACKGROUND: Plantar fibromatosis is a benign disease creating nodules on the medial plantar side of affected patients. While surgical removal is regarded as the therapeutic mainstay, recurrence rates and impairment of daily activities remains substantial. High-energy focussed extracorporeal shockwave therapy has been suggested to be potentially effective in plantar ...
Olmstead Spencer B - - 2012
We conducted a qualitative content analysis of written responses from 148 college men to questions about pregnancy resolution and marriage in the event of an unplanned pregnancy. We used Marsiglio's ( 1991 ) concepts of procreative consciousness and responsibility as a source of theoretical sensitivity during data analysis. Men's written ...
Ito Ken K Molecular Imaging Program, Department of Radiology, Stanford University, Stanford, California, - - 2012
Non-Hodgkin lymphoma (NHL) is a heterogeneous and highly disseminated disease, but the mechanisms of its growth and dissemination are not well understood. Using a mouse model of this disease, we used multimodal imaging, including intravital microscopy (IVM) combined with bioluminescence, as a powerful tool to better elucidate NHL progression. We ...
Paushter Daniel H DH Department of Transplant/Surgery, University of Illinois at Chicago, Chicago, IL 60612, - - 2013
We previously reported a small-scale study on the efficacy of histidine-tryptophan-ketoglutarate (HTK) solution versus University of Wisconsin (UW) solution on pancreas preservation for islet isolation. In this large-scale, retrospective analysis (n = 252), we extend our initial description of the impact of HTK on islet isolation outcomes and include pancreatic ...
Bailarote Bruno Cachapa - - 2012
• Premise of the study: Orchids rely on mycorrhizal fungi for seed germination, and many species maintain associations during later stages in their life cycle. Because of the critical dependence of orchids on fungi it has been suggested that the degree of mycorrhizal specificity may be associated with rarity and ...
Crane Frederick L FL Biology Department, Purdue University, West Lafayette, IN, - - 2013
For more than 20 years, the observation that impermeable oxidants can stimulate cell growth has not been satisfactorily explained. The discovery of sirtuins provides a logical answer to the puzzle. The NADH-dependent transplasma membrane electron transport system, which is stimulated by growth factors and interventions such as calorie restriction, can ...
Röhlich Christoph - - 2012
Many reports on water-compatible palladium catalysts have appeared in the recent literature. For hydrophobic substrates, mixtures with pure water are biphasic, and it is widely not regarded that the elusive locality of the catalytic process (in water, the organic layer, or at the phase boundary) has an important impact on ...
Baliga Manjeshwar S - - 2012
Abstract Background: In spite of the tremendous progress achieved in medical sciences in the last century, the management of diabetes mellitus, a disease as old as mankind, is poor. Diabetes is currently the world's largest endocrine disorder, and estimates are that it affects almost 5% of the population. Ayurveda, the ...
Arantes Ferreira Peres Wilza - - 2012
Hepatic vitamin A stores should be the best early indicator of vitamin A status because more than 90% of total body vitamin A is stored in the liver. The objective of the present study was to evaluate the hepatic vitamin A stores in all stages of chronic liver disease (CLD), ...
Smith Leah - - 2012
Abstract Background: Approximately 20% of deaths in the United States occur in the intensive care unit (ICU). Physician trainees lack the practical communication skills required for end-of-life care, including establishing patient preferences, participating in shared decision making, discussing prognosis, and delivering bad news. Utilizing facilitated, case-based, peer interactions, we sought ...
Karimi Mohammad - - 2012
Background: Scottish-Rite orthosis is one of the conservative methods used to treat Legg-Calvé-Perthes disease. As there was not enough evidence to show the effects of using this orthosis on reducing the loads applied on the limb, this research aimed to find the influence of this orthosis.Case Description and Methods: A ...
Bernard Jessica K JK Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California 90089, - - 2012
Expression of the ErbB4 tyrosine kinase is elevated in colonic epithelial cells during inflammatory bowel disease, whereas ErbB4 overexpression in cultured colonocytes blocks TNF-induced apoptosis in a ligand-dependent manner. Together, these observations suggest that ErbB4 induction may be a protective response. However, the effects of ErbB4 signaling in the colonic ...
Yasumizu Yota - - 2012
【Objectives】 Lymphocele development is the most frequently reported postoperative complication of pelvic lymph node dissection (PLND) performed with laparoscopic radical prostatectomy (LRP). This study evaluated the efficacy of a vessel sealing device (VSD) for the prevention of lymphocele development. 【Methods】 A total of 120 patients who underwent LRP with PLND ...
Blot F - - 2012
Acute respiratory failure (ARF) is frequent and often fatal in patients with a malignancy. However, there is not one type of "oncology patient", and it's high time that both clinical management and further studies consider specific populations rather than the heterogeneous and artificial group of "cancer patients". This individual-based approach ...
Bourgognon J-M - - 2012
Fear memories are acquired through neuronal plasticity, an orchestrated sequence of events regulated at circuit and cellular levels. The conventional model of fear acquisition assumes unimodal (for example, excitatory or inhibitory) roles of modulatory receptors in controlling neuronal activity and learning. Contrary to this view, we show that protease-activated receptor-1 ...
Kawabata Kohsuke - - 2012
Electrochemical polymerization of a series of N-alkyl-2,7-di(2-thienyl)carbazoles in acetonitrile was performed to obtain conjugated polymers with fluorescence. Scanning electron and atomic force microscopies revealed that the surface morphology of the polymer films significantly depends on the alkyl chain lengths of the polymers. Particularly, a homopolymer bearing hexyl groups and copolymers ...
Sabbatini Paul J - - 2012
PURPOSE: Long peptides are efficiently presented to both CD4+ and CD8+ T-cells after intracellular processing by antigen presenting cells. To investigate the safety and in vivo immunogenicity of synthetic overlapping long peptides (OLP) from a human tumor self-antigen, we conducted a phase I clinical trial with OLP from cancer-testis antigen ...
Giurgescu Carmen C College of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA. - - 2012
To (a) examine the relationships among objective and perceived indicators of neighborhood environment, racial discrimination, psychological distress, and gestational age at birth; (b) determine if neighborhood environment and racial discrimination predicted psychological distress; (c) determine if neighborhood environment, racial discrimination, and psychological distress predicted preterm birth; and (d) determine if ...
Duran-Prado Mario - - 2012
Somatostatin (SST) and its related peptide cortistatin (CORT) exert their multiple actions through binding to the SST receptor (sst) family, generally considered to comprise five G-protein coupled receptors (GPCRs) with 7 transmembrane domains (TMD), named sst1-sst5, plus a splice sst2B variant. However, we recently discovered that human and rodent sst5 ...
Chatterjee Sarmishtha - - 2012
In the present study, we attempted to elucidate the induction of autophagy in rat hepatocytes by a low concentration of mercury. Hepatocytes treated with different doses of mercuric chloride (HgCl(2); 1, 2.5, 5 and 10 µM) and at different time intervals (0 min, 30 min, 1 h, 2 h and ...
Boyce Richard D - - 2012
BACKGROUND:Food and Drug Administration (FDA) regulations mandate that package inserts (PIs) include observed or predicted clinically significant drug-drug interactions (DDIs), as well as the RESULTS: To quantify how frequently observed metabolic inhibition DDIs affecting US-marketed psychotropics are present in FDA-approved PIs and what influence the source of DDI information has ...
Veronesi Francesca - - 2012
Mesenchymal stem cells (MSCs) from bone marrow (BM) are widely used for bone and less for cartilage tissue regeneration due to their self-renewal and differentiating properties into osteogenic or chondrogenic lineages. This review considers the last decade of clinical trials involving a two-step procedure, by expanding in vitro MSCs from ...
Su Yu-Sheng - - 2012
Realization of a ubiquitous clean energy future depends critically on the efficient storage and utilization of renewable energies. Lithium-ion batteries are appealing in this regard, but low-cost, abundant, safe, high energy-density electrode materials need to be developed to adopt them. Here we present a sulfur-multi-wall carbon nanotube (MWCNT) composite cathode ...
Wohlers Janet - - 2012
ABSTRACT: INTRODUCTION: In granulomatosis with polyangiitis (GPA), a complex autoimmune small-vessel vasculitis frequently associated with chronic necrotizing inflammation of the nasal mucosa, elevated nasal Staphylococcus (S.) aureus carrier rates are a risk factor for relapse. As cytokines are primarily involved in the regulation of defense against potentially pathogenic microorganisms, the ...
Smirnova Irina - - 2012
WT lactose permease of Escherichia coli (LacY) reconstituted into proteoliposomes loaded with a pH-sensitive fluorophore exhibits robust uphill H(+) translocation coupled with downhill lactose transport. However, galactoside binding by mutants defective in lactose-induced H(+) translocation is not accompanied by release of an H(+) on the interior of the proteoliposomes. Because ...
Mao Mao - - 2012
We synthesized a series of donor-substituted tridurylboranes containing different types and number of chromophores including 1-pyrene (PB1-3), 3-carbazole (CBC1-3), or substituted p-carbazol-N-phenyl (CBN3a-c) as various donor-acceptor (D-A) molecules. The photophysical and electrochemical properties of these twisted D-A molecules were investigated by means of UV/Vis absorption and fluorescence spectroscopy as well ...
Coutts David J C DJ Wellcome Trust-MRC Cambridge Stem Cell Institute and Department of Veterinary Medicine, University of Cambridge, Cambridge, - - 2013
Transplanted olfactory ensheathing cells (OECs) contribute to functional recovery in a range of CNS injuries by several mechanisms, one of which is potentially their ability to form myelin sheaths. OECs sourced from donors of different ages have been shown to remyelinate in several in vitro and in vivo models. However, ...
Price K J KJ Department of Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. - - 2013
The prognosis for adult acute leukemia patients that require intensive care unit (ICU) admission and invasive mechanical ventilation is poor. We aimed to identify prognostic indicators of 30-day hospital mortality in adult patients who had acute leukemia and respiratory failure, who had received invasive mechanical ventilation in the ICU but ...
Devnani Mahesh - - 2012
Introduction The first decade of the 21st century has witnessed three major influenza public health emergencies: (1) the severe acute respiratory syndrome of 2002-2003; (2) the avian flu of 2006; and (3) the 2009 H1N1 pandemic influenza. An effective public health response to an influenza public health emergency depends on ...
Chamorro S - - 2012
Polyphenols are chemically and biologically active compounds. Grape seed extracts (GSEs) have been widely used as a human food supplement for health promotion and disease prevention. However, there is little information regarding its application in animal feeds. An experiment was conducted to investigate the effect of inclusion of GSE at ...
Barreira Rebeca Iglesias - - 2012
OBJECTIVE:To report a paradoxical reaction of Raynaud phenomenon following the repeated administration of iloprost in a patient with diffuse cutaneous systemic sclerosis with vascular involvement.CASE SUMMARY:In January 2006, a 40-year-old male was diagnosed with diffuse cutaneous systemic sclerosis with pulmonary, esophageal, cutaneous, and vascular involvement (Raynaud phenomenon, with digital ulcers ...
Gowda Charitha - - 2012
Background: There has been a rise in the number of vaccine-hesitant parents (VHPs) in the US, many of whom express reservations about administering the MMR vaccine to their children. We studied the relative importance of attitudinal barriers to MMR vaccination among VHPs with differing levels of MMR vaccine-hesitancy.   Methods: ...
Botta Roberta - - 2012
Background Orbital fibroblast proliferation and hyaluronic acid (HA) release are responsible for some of the clinical features of Graves' Ophthalmopathy (GO). Thus, inhibition of these processes may be a possible therapeutic approach to this syndrome. Enalapril, a widely used anti-hypertensive drug, was found to have some inhibitory actions on fibroblast ...
Vivar Carmen - - 2012
Adult hippocampal neurogenesis is considered important for cognition. The integration of newborn dentate gyrus granule cells into the existing network is regulated by afferent neuronal activity of unspecified origin. Here we combine rabies virus-mediated retrograde tracing with retroviral labelling of new granule cells (21, 30, 60, 90 days after injection) ...
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