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Carrancio S - - 2012
Hematopoietic stem cell transplantation (HSCT) using umbilical cord blood (UCB) progenitors is increasingly being used. One of the problems that may arise after UCB transplantation is an impaired engraftment. Either intrabone (IB) injection of hematopoietic progenitors or mesenchymal stem cells (MSCs) co-administration have been proposed among the strategies to improve ...
Zhao Min - - 2012
Ovarian cancer is the leading cause of death in gynecological cancer. Studies suggested Rab25 is involved in the pathogenesis of ovarian cancers. We here investigated the expression of Rab25 is in all ovarian cancers and whether the expression of Rab25 is associated with peritoneal metastasis. Fifty-nine ovarian cancer patients were ...
George Subi Jacob - - 2012
Stereoselective non-covalent synthesis of one-dimensional helical self-assembled stacks of achiral oligo(p-phenylenevinylene) ureidotriazine (AOPV3) monomers is obtained by a chiral supramolecular auxiliary approach. The racemic mixture of helical stacks of achiral AOPV3 molecules is converted into homochiral helical stacks, as shown by both spectroscopic measurements and molecular modeling simulations. The conversion ...
Browning Jeffrey D JD The Advanced Imaging Research Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. - - 2012
The use of deuterated water as a method to measure gluconeogenesis has previously been well validated and is reflective of normal human physiology. However, there has been concern since the method was first introduced that transaldolase exchange may lead to the overestimation of gluconeogenesis. We examined the impact of transaldolase ...
Li Huan - - 2012
Optomechanical phenomena in photonic devices provide a new means of light-light interaction mediated by optical force actuated mechanical motion. In cavity optomechanics, this interaction can be enhanced significantly to achieve strong interaction between optical signals in chip-scale systems, enabling all-optical signal processing without resorting to electro-optical conversion or nonlinear materials. ...
Naidoo S - - 2012
SETTING: Primary health clinics in KwaZulu-Natal, South Africa.OBJECTIVE: To assess and describe current practices in infection control at local government primary health clinics.DESIGN: A descriptive study using a standardised tool to assess adherence to recommended infection control policies in 51 primary health clinics in 2009-2010. Administrative policies, engineering controls and ...
Kwon Young-Min - - 2012
OBJECTIVES:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease, and its prevalence is much higher in obese individuals. NAFLD is closely related to metabolic syndrome (MetS); however, most concepts about the relationship between NAFLD and MetS have emphasized obesity, although NAFLD is not a rare ...
Nguyen-Truong Connie K Y - - 2012
OBJECTIVE: To explore factors potentially influencing Pap testing practices among Vietnamese American immigrant women (VIW, foreign-born) and describe their awareness of cervical cancer screening resources in their community. DESIGN: Descriptive study guided by the ecological model and community-based participatory research principles. SETTING: Portland, Oregon, metropolitan area. PARTICIPANTS: Vietnamese American immigrant ...
Shajib Md Tariqul Islam - - 2012
Certain isoflavones are plant growth inhibitors, and biochanin A is a major isoflavone in clover species used for weed management. The effect of biochanin A on the monocot weed species Echinochloa crus-galli L. and Lolium perenne L. and dicot species Silene noctiflora L., Geranium molle L. and Amaranthus caudatus L. ...
Eger Wilhelm A - - 2012
We studied computationally, on the model compound ethylenediamine, the insertion of carbon dioxide into diamines, yielding cyclic urea compounds. Two mechanisms were elaborated, depending on the value of the dielectric constant (DC) of the solvent. Accordingly, reaction mixtures with a high DC lead to carbamates, whereas lower DC values result ...
Kunz Vandeni C - - 2012
OBJECTIVE: To evaluate and to compare the cardiorespiratory and metabolic variables at the ventilatory anaerobic threshold level (AT) and at submaximal cardiopulmonary exercise testing (CPET) in both, healthy volunteers and in patients in the early phase after acute myocardial infarction (AMI). METHOD: Twenty-six volunteers underwent a submaximal or symptom-limited cardiopulmonary ...
Dorrer Christian - - 2012
Captive bubble experiments on surface-engineered silicon substrates with precisely tuned roughness and surface chemistry are reported. In these experiments, the substrates were submerged into water and air bubbles were dispensed from below. Our measurements revealed a super-bubble-repellent behavior, with bubbles freely moving around on the submerged surfaces. Drawing an analogy ...
Lovell Rebecca M - - 2012
OBJECTIVES:Irritable bowel syndrome (IBS) and gastro-esophageal reflux-type symptoms (GERS) are highly prevalent in the general population, and the two appear to be related. We conducted a systematic review and meta-analysis to estimate the prevalence of GERS in individuals with IBS, and to quantify the overlap between the two disorders.METHODS:MEDLINE, EMBASE, ...
Fernández-Del-Olmo Miguel - - 2012
BACKGROUND: Auditory external cues enhance step initiation in Parkinson's disease (PD) patients. We wanted to explore whether a startle reaction has a comparable effect on step initiation in PD. METHODS: Thirteen PD patients and 13 aged-matched controls participated in this study. Electromyography pattern and onset toe-off time during a step ...
Lash Timothy David - - 2012
Tripyrranes with tert-butyl and phenyl substituents have been prepared and used to synthesize oxybenziporphyrins, oxypyriporphyrins, benzocarbaporphyrins and azuliporphyrins with phenyl and tert-butyl substituents via a "3 + 1" methodology. The proton NMR spectra for the tripyrrane dibenzyl esters indicate that these tripyrrolic systems take on a helical conformation that favors ...
Li Peng-Fei - - 2012
Starting from triptycene, 2-, (2,6- or 2,7-)di-, and (2,6,14- or 2,7,14-)tri-formyl or acetyl substituted triptycenes were selectively synthesized. The derivatization of the formyl or acetyl substituted triptycenes was then investigated. Consequently, it was found that the formyl-substituted triptycenes could be transformed into cyano substituted triptycene derivatives by the aldoxime formation ...
Gao Fei F Division of Reproductive Sciences and Perinatal Institute, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, - - 2012
Embryo-uterine interaction during early pregnancy critically depends on the coordinated expression of numerous genes at the site of implantation. The epigenetic mechanism through DNA methylation (DNM) plays a major role in the control of gene expression, although this regulatory event remains unknown in uterine implantation sites. Our analysis revealed the ...
Imai Satoki - - 2012
Organic anion transporting polypeptides (rodents, Oatps; human, OATPs) are primarily involved in the transmembrane transport of a wide range of endogenous and exogenous compounds. Multiple mouse Oatp1 isoforms are closely located on chromosome 6 where each isoform shows distinct tissue distribution; Oatp1b2, Oatp1a6 and Oatp1c1 are expressed exclusively in the ...
He Jianwei - - 2012
Chicken cystatin (cC) mutant I66Q is located in the hydrophobic core of the protein and increases the propensity for amyloid formation. Here, we demonstrate that under physiological conditions, the replacement of Ile with the Gln in the I66Q mutant increases the susceptibility for the disulfide bond Cys71-Cys81 to be reduced ...
Conejero Salvador - - 2012
Unsaturated [Tp(Me2)Ir(iii)] fragments, readily generated from compounds [Tp(Me2)Ir(C(6)H(5))(2)(N(2))], () and [Tp(Me2)Ir(η(4)-CH(2)[double bond, length as m-dash]C(Me)C(Me)[double bond, length as m-dash]CH(2)] () (Tp(Me2) = hydrotris(3,5-dimethylpyrazolyl)borate), induce the isomerisation of the polypyridines, 2,2'-bipyridine, 1,10-phenanthroline and 2,2':6'2''-terpyridine, to form complexes that contain the carbene tautomer of these ligands. For terpy, a binuclear compound has ...
Polak David - - 2012
Background: Periodontitis is a polymicrobial infectious disease. A novel potential chemical treatment modality may lie in bacterial anti-adhesive materials, such as cranberry juice fractions. The aim of this study was to explore the effect of high molecular weight cranberry constituent (NDM - non-dialysable material) on the virulence of a mixed ...
de Bot Susanne T - - 2012
Although the combined presence of ataxia and pyramidal features has a long differential, the presence of a true spastic-ataxia as the predominant clinical syndrome has a rather limited differential diagnosis. Autosomal recessive ataxia of Charlevoix-Saguenay, late-onset Friedreich ataxia, and hereditary spastic paraplegia type 7 are examples of genetic diseases with ...
Hasanayn Faraj - - 2012
The potential energy surface (PES) of H(2) addition to the Ru═N bond of a model five-coordinate ruthenium amide (Ru═N), leading to an octahedral trans-Ru(H)(2)(diamine)(diphosphine) (HRu-NH) and subsequent acetophenone hydrogenation, is studied using M06 density functional theory methods. A qualitative molecular orbital analysis reveals that H(2) addition to the ground state ...
Sung Yu-Hsiang - - 2012
Ohmic contact formation at the interface of the Au nanoparticle (NP)-ZnO nanosheet (NS), which facilitates photoelectron transfer from ZnO NSs to Au NPs, is determined by scanning Kelvin microscopy for the first time. Reduction of charge recombination in the ZnO NSs confirmed by the quench of green band emission results ...
Liva Sarah J - - 2012
OBJECTIVE: To test whether demographic characteristics predict registered nurses' attitudes toward birth practices. DESIGN: A secondary analysis of a cross-sectional survey, the National Maternity Care Attitudes Survey. SETTING: A national survey conducted with health care providers providing maternity care in Canada. PARTICIPANTS: A convenience sample of 545 registered nurses. METHODS: ...
Takahashi Yoko Y Department of Head and Neck Surgery and Pathology, The University of Texas MD Anderson Cancer Center, Baylor College of Medicine, Houston, Texas 77030, - - 2012
Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive cancer. Despite the use of multimodality treatment, the overall prognosis remains poor. To better understand the biologic features of SNUC and help develop new therapies for the disease, we established SNUC cell lines and characterized their biologic behaviors. Cell lines were ...
Jakes Peter - - 2012
The electrocatalytical process at the air cathode in novel silicon-air batteries using the room-temperature ionic liquid hydrophilic 1-ethyl-3-methylimidazolium oligofluorohydrogenate [EMI⋅2.3 HF⋅F] as electrolyte and highly doped silicon wafers as anodes is investigated by electrochemical means, X-ray photoelectron spectroscopy (XPS), and electron paramagnetic resonance (EPR) spectroscopy. The results obtained by XPS ...
Babik Barna - - 2012
ABSTRACT: INTRODUCTION: The slope of phase III of the capnogram (SIII) relates to progressive emptying of the alveoli, a ventilation/perfusion mismatch, and ventilation inhomogeneity. SIII depends not only on the airway geometry, but also on the dynamic respiratory compliance (Crs); this latter effect has not been evaluated. Accordingly, we established ...
Kowalski Damian - - 2012
In and out of tube: Robust poly-3,4-ethylene-dioxythiophene nanostructures in the form of nanopore arrays and inverse nanotube arrays are obtained by site-selective deposition into TiO(2) nanotubes. The deposition process critically depends on the applied potential and is in line with three-dimensional (3D) progressive and 3D instantaneous nucleation-growth mechanism, leading to ...
Mohamed Zainaba Z University College London, Institue of Child Health, Developmental Endocrinology Research Clinical, Molecular Genetics Unit, London, United - - 2012
Hyperinsulinaemic hypoglycaemia (HH) is characterized by unregulated insulin secretion from pancreatic β-cells. Untreated hypoglycaemia in infants can lead to seizures, developmental delay, and subsequent permanent brain injury. Early identification and meticulous managementof these patients is vital to prevent neurological insult. Mutations in eight different genes (ABCC8, KCNJ11, GLUD1, CGK, HADH, ...
Mammen Lena - - 2012
The effect of nanoroughness on contact angles and pinning is investigated experimentally and numerically for low energy surfaces. Nanoroughness can improve or impair the liquid repellency of superhydrophobic surfaces, which were made from assembled raspberry particles. In the studied system nanoroughness is introduced by chemical vapor deposition of tetraethoxysilane and ...
Fujita Daishi - - 2012
Protein encapsulation has long attracted many chemists and biologists because of its potential to control the structure and functions of proteins, but has been a daunting challenge because of their incommensurably larger size compared with common synthetic hosts. Here we report the encapsulation of a small protein, ubiquitin, within giant ...
Graessler J - - 2012
Roux-en-Y gastric bypass (RYGB) has become a prominent therapeutic option for long-term treatment of morbid obesity and type 2 diabetes mellitus (T2D). Cross talk and pathogenetic consequences of RYGB-induced profound effects on metabolism and gut microbiome are poorly understood. The aim of the present study therefore was to characterize intra-individual ...
Teh Bing Mei - - 2012
Tympanic membrane perforations are common, with current treatments for chronic perforations involving surgery using various graft materials, from autologous cartilage or fascia through to paper patch. Recent research developments in this field have begun applying the principles of tissue engineering, with appropriate scaffolds, cells and bioactive molecules. This has revolutionised ...
Tillman Bryan - - 2012
Cardiac and vascular diseases represent one of the most substantial medical areas for the applications of regenerative medicine. Despite advances in endovascular repair, surgical intervention and disease management, atherosclerosis and heart failure continue to be prominent health problems. This report analyzes the regenerative medicine treatment opportunities in both cardiovascular and ...
Michael M - - 2012
Cross-sectional, survey. To describe the challenges in rehabilitating patients with spinal cord injury in the orthopaedic centres of the International Committee of the Red Cross in Afghanistan. Afghanistan (Kabul, Herat, Mazar-i-Sharif, Jalalabad, Gulbahar), April 2012. Semi-structured interviews were conducted with managers and professional staff of ICRC and other concerned organizations/institutions ...
Liu Jinfeng - - 2012
Lung cancer is a highly heterogeneous disease in terms of both underlying genetic lesions and response to therapeutic treatments. We performed deep whole-genome sequencing and transcriptome sequencing on 19 lung cancer cell lines and three lung tumor/normal pairs. Overall, our data show that cell line models exhibit similar mutation spectra ...
Wang H - - 2012
Forming a good Ge/dielectric interface is important to improve the electron mobility of a Ge metal oxide semiconductor field-effect transistor. A thin yttrium germanate capping layer can improve the properties of the Ge/GeO(2) system. We employ electronic structure calculations to investigate the effect of oxygen vacancies in yttrium-doped GeO(2) and ...
Gabriel Curtis L CL Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, - - 2012
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies against self-antigens such as double-stranded DNA and phospholipids. Classical comorbidities of SLE include glomerulonephritis, infection, cardiovascular disease, arthritis, skin disorders, and neurological disease. In addition to these classical comorbidities, there is emerging evidence that SLE patients ...
Bosman Peter A N - - 2012
Abstract We describe a parameter-free Estimation-of-Distribution Algorithm (EDA) named Adapted Maximum-Likelihood Gaussian Model Iterated Density-Estimation Evolutionary Algorithm (AMaLGaM-IDEA, or AMaLGaM for short) for numerical optimization. AMaLGaM is benchmarked within the 2009 Black-Box Optimization Benchmarking (BBOB) framework and compared to a variant with incremental model building (iAMaLGaM). We study the implications ...
Vereecken L - - 2012
The reaction of Criegee intermediates (CI) with NO and RO(2) radicals is studied for the first time by theoretical methodologies; additionally, the reaction of CI with SO(2) molecules is re-examined. The reaction of CI with NO was found to be slow, with a distinct energy barrier. Their reaction with RO(2) ...
Mosley Garrett L - - 2012
Vesicles represent an important class of nanoscale drug delivery vehicles. To significantly reduce the time and resources that are required to optimize these drug carriers, this review article discusses the mathematical models that have been derived for understanding the formation of vesicles and their stability, as well as for predicting ...
Moon Ji Sook - - 2012
Stem cell-based cell replacement of lost midbrain dopamine (mDA) neurons is a potential therapy for Parkinson's disease (PD). Toward this goal, it is critical to optimize various aspects of cell transplantation and to assess functional recovery through behavioral tests in validated animal model(s) of PD. At present, cell transplantation studies ...
Budroni M A - - 2012
A reaction-diffusion-convection (RDC) model is introduced to analyze convective dynamics around horizontally traveling fronts due to combined buoyancy- and surface tension-driven flows in vertical solution layers open to the air. This isothermal model provides a means for a comparative study of the two effects via tuning two key parameters: the ...
Johns James E JE Department of Materials Science, Northwestern University, Evanston, Illinois 60208-3108, United - - 2013
Although graphene's physical structure is a single atom thick, two-dimensional, hexagonal crystal of sp(2) bonded carbon, this simple description belies the myriad interesting and complex physical properties attributed to this fascinating material. Because of its unusual electronic structure and superlative properties, graphene serves as a leading candidate for many next ...
Shin Ji-Hyeon - - 2012
ObjectivesThe purpose of the present study was to investigate the effect of nucleotide-binding oligomerization domain 1 (NOD1), an innate immune sensor, on allergic inflammation and induction of regulatory T cells in a mouse model of allergic rhinitis. We also aimed to explore whether there were differences in the effect of ...
Xiang Zheng - - 2012
Two new saponins were isolated from the leaves of Panax quinquefolium and their structures were elucidated as 3β, 6α, 20S-trihydroxy-12β, 23R-epoxydammar-24-ene 6-O-[α-L-rhamnosyl(1 → 2)-β-D-glucopyranosyl]-20-O-β-D-glucopyranoside (1) and 3β, 20S-dihydroxy-12β, 23R-epoxydammar-24-ene 3-O-[β-D-glucopyranosyl(1 → 2)-β-D-glucopyranosyl]-20-O-β-D-glucopyranoside (2) on the basis of physicochemical evidence.
Wang Yifang - - 2012
CKIP-1 is an activator of the Smurf1 ubiquitin ligase acting to promote the ubiquitylation of Smad5 and MEKK2. The mechanisms involved in the recognition and degradation of these substrates by the proteasome remain unclear. Here, we show that CKIP-1, through its leucine zipper, interacts directly with the Rpt6 ATPase of ...
Joosten Antoine - - 2012
A highly selective oxidative palladium(II)-catalyzed (Wacker-type) cyclization of readily available allylic tosylcarbamates is reported. This operationally simple catalytic reaction furnishes tosyl-protected vinyl-oxazolidinones, common precursors to syn-1,2-amino alcohols, in high yield and excellent diasteroselectivity (>20:1). It is demonstrated that both stoichiometric amounts of benzoquinone (BQ) as well as aerobic reoxidation (molecular ...
Bouma Marinus J - - 2012
I: hyperfond of a triple bond! The first one-pot synthesis of alkynyl(aryl)iodonium salts directly from aryl iodides has been developed. The reaction is fast and high yielding, and can be extended to the synthesis of alkynyl benziodoxolones. The developed methodology is expected to greatly facilitate the access to this interesting ...
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