Search Results
Results 501 - 550 of 3178
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Karade Vikas - - 2012
ABSTRACT: BACKGROUND: In a standard total knee replacement, tibial component alignment is a key factor for the long term success of the surgery. The purpose of this study is to compare the accuracy of extramedullary and intramedullary tibial cutting guides used in indigenous and imported implants respectively, in positioning of ...
Hennig Bianca P - - 2012
Chromatin organization is essential for defining transcription units and maintaining genomic integrity in eukaryotes. In this study, we found that deletion of the Schizosaccharomyces pombe Chd1 chromatin remodelers, hrp1 and hrp3, causes strong, genome-wide accumulation of antisense transcripts. Nucleosome mapping revealed a specific role for Chd1 remodelers in the positioning ...
Chuang Victor Tuan Giam - - 2012
OBJECTIVE:To comprehensively review the literature regarding the efficacy, safety, and costs associated with the use of levoleucovorin in cancer treatment and to assess whether levoleucovorin would be a reasonable alternative to the use of racemic leucovorin.DATA SOURCES:A MEDLINE search was conducted for English-language human studies published between January 1980 and ...
Ng Tsz Kin - - 2012
Adult stem cells are critical for the healing process in regenerative medicine. However, cigarette smoking inhibits stem cell recruitment to tissues and delays the wound healing process. This study investigated the effect of nicotine, a major constituent in the cigarette smoke, on the regenerative potentials of human mesenchymal stem cells ...
Smartt H J M HJ Cancer Research UK Colorectal Tumour Biology Research Group, School of Cellular and Molecular Medicine, University Walk, University of Bristol, Bristol BS8 1TD, - - 2012
Levels of the pro-tumorigenic prostaglandin PGE(2) are increased in colorectal cancer, previously attributed to increased synthesis through COX-2 upregulation and, more recently, to decreased catabolism. The functionally linked genes 15-prostaglandin dehydrogenase (15-PGDH) and the prostaglandin transporter PGT co-operate in prostaglandin degradation and are downregulated in colorectal cancer. We previously reported ...
Franchi F - - 2012
BACKGROUND: Echocardiography is a valuable technique to assess cardiac output (CO) in trauma patients, but it does not allow a continuous bedside monitoring. Beat-to-beat CO assessment can be obtained by other techniques, including the pulse contour method MostCare. The aim of our study was to compare CO obtained with MostCare ...
Amboni Marianna - - 2012
Although in recent years the relationship between cognition and gait in Parkinson's disease (PD) has received increasing attention, the specific connections between gait patterns and cognitive features are not fully understood. The objective of this study was to describe the gait patterns in patients affected by PD with or without ...
Vöhringer-Martinez Esteban - - 2012
Pin1 represents an enzyme that specifically catalyzes the isomerization of peptide bonds between phosphorylated threonine or serine residues and proline. Despite its relevance as molecular timer in a number of biological processes related to cancer and Alzheimer disease a detailed understanding of the factors contributing to the catalysis is still ...
Saines Paul J - - 2012
The structures of seven new transition metal frameworks featuring Mn, Co, or Zn and either the meso or chiral d and l isomers of the 2,3-dimethylsuccinate ligand are reported. Frameworks that exhibit two-dimensional covalently bonded layers with weak interlayer interactions can be made with all three cations by incorporation of ...
Dong Wenjun - - 2012
A simple chemical solution route for the synthesis of large-scale high-quality Ag nanoparticle functionalized molybdenum oxide nanowire at room temperature has been developed. In the synthesis, the protonated amine was intercalated into the molybdenum bronze layers to reduce the electrostatic force of the lamellar structures, and then the Ag nanoparticle ...
Dai Fei - - 2012
The Near East Fertile Crescent is well recognized as a primary center of barley origin, diversity, and domestication. A large number of wild barleys have been collected from the Tibetan Plateau, which is characterized by an extreme environment. We used genome-wide diversity array technology markers to analyze the genotypic division ...
Lambertini Elisabetta - - 2012
ABSTRACT: BACKGROUND: Breast cancer and its metastatic progression is mainly directed by epithelial to mesenchymal transition (EMT), a phenomenon supported by specific transcription factors and miRNAs. METHODS: In order to investigate a possible correlation between Slug transcription factor and miR-221, we performed Slug gene silencing in MDA-MB-231 breast cancer cells ...
Selander Jenny - - 2012
OBJECTIVES: The aim of this study was to assess the joint effect of job strain and both road-traffic and occupational noise on myocardial infarction (MI). METHOD: We conducted a population based case-control study on first time MI in Stockholm County during 1992-1994. Participants answered a questionnaire and underwent a physical ...
Zhang Zhe - - 2012
We develop a pyrazoline-based fluorescent sensor for biological Zn(2+) detection. The sensor shows good binding selectivity for Zn(2+) over competing metal with 40-fold fluorescence enhancement in response to Zn(2+). The new probe is cell-permeable and can be used to detect intracellular zinc ions in living neuron cells.
Filipazzi Paola - - 2012
PURPOSE: The progressive immune dysfunctions that occur in advanced melanoma patients make them unlikely to efficiently respond to cancer vaccines. A multicenter randomized phase II trial was performed to test whether immunization with modified HLA-class I tumor peptides in the context of adjuvant therapy results in better immunological responses and ...
Chen Guo - - 2012
In this work, 2,4-bis[4-(N,N-diisobutylamino)-2,6-dihydroxyphenyl] squaraine (SQ) was systematically studied as an electron donor in solution processed photovoltaic cells, showing power conversion efficiency of >4.0% under AM1.5G 1 sun illumination at room temperature. Low mobilities were found to limit charge transport in the bulk heterojunctions. Efficiency was thus improved to 5.1% ...
Gerritz Samuel W - - 2012
This report describes the discovery and optimization of a BACE-1 inhibitor series containing an unusual acyl guanidine chemotype that was originally synthesized as part of a 6041-membered solid-phase library. The synthesis of multiple follow-up solid- and solution-phase libraries facilitated the optimization of the original micromolar hit into a single-digit nanomolar ...
Ma Jincai - - 2012
Persistence of Escherichia coli O157:H7 in 32 (16 organically and 16 conventionally managed soils) from California (CA) and Arizona (AZ) was investigated. Results showed that the longest survival (ttd, time needed to reach detection limit, 100 CFU g-1 dry soil) of E. coli O157:H7 was observed in the soils from ...
Belding Stephen R - - 2012
The steady-state voltammetry for a one electron reduction, A + e(-) ⇌ B, is studied at a microdisc electrode in the absence of excess supporting electrolyte. For the first time, the full voltammetric waveshape is numerically simulated. Using a combination of theory and experiment, the voltammetry is investigated as a ...
Choi Su-Mi SM Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, - - 2012
Influenza RNA in blood (viremia) was detected in 9 of 79 (11.4%) hematopoietic cell transplant recipients with influenza, and was less frequently observed in patients with upper respiratory tract disease only and more frequently in patients infected with 2009 pandemic influenza A/H1N1 strain (versus seasonal strains). Viremia increased the risk ...
Clark Kristopher K Medical Research Council Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee, DD1 5EH, United - - 2012
Macrophages acquire strikingly different properties that enable them to play key roles during the initiation, propagation, and resolution of inflammation. Classically activated (M1) macrophages produce proinflammatory mediators to combat invading pathogens and respond to tissue damage in the host, whereas regulatory macrophages (M2b) produce high levels of anti-inflammatory molecules, such ...
Kim Jae Hui - - 2012
Purpose: To investigate changes in thickness profiles of retinal layers after resolution of recent-onset rhegmatogenous retinal detachment Methods: Spectral domain optical coherence tomography (SD-OCT) scans were performed for 28 patients diagnosed with unilateral inferior-half or superior-half retinal detachment who underwent retinal reattachment surgery. The thickness of each retinal layer was ...
Nguyen Christine - - 2012
Objective :  Our study aimed to use national data to assess the perioperative outcomes of craniosynostosis surgical repair. Design :  Data were obtained from the Agency for Healthcare Research and Quality Healthcare Cost and Utilization Project Kids Inpatient Database from 1997, 2000, 2003, and 2006. Setting :  Community hospitals in ...
Cuadrado-Godia Elisa - - 2012
OBJECTIVE: To describe the severity and early neurological deterioration (END) in patients with symptomatic carotid stenosis and to analyse the influence of related factors. METHODS: Observational cohort study of patients with ischaemic stroke, ipsilateral carotid stenosis and without evidence of cardiac sources of embolism prospectively recorded since January 2003 to ...
Motiwala Shweta R - - 2012
Over the last several years, cardiac biomarkers have been shown to be increasingly useful for disease screening, diagnosis, and prognostication. The most widely used biomarkers in heart failure (HF) are natriuretic peptides, which can aid in diagnosing HF, while also identifying those diagnosed who are at higher risk of adverse ...
Yang Guochun - - 2012
We have investigated the chiroptical, linear, and second-order nonlinear optical (NLO) properties of seven binaphthol derivatives and elucidated structure-property relationships from the micromechanism for the first time. The excitation energies, oscillator strengths, and rotational strengths of the 150 lowest energy electron excitations for the most stable conformers have been calculated ...
Zimmermann Ralf - - 2012
Biohybrid hydrogels combining electrically neutral synthetic polymers and highly anionic glycosaminoglycans (GAGs) offer exciting options for regenerative therapies as they allow for the electrostatic conjugation of various growth factors. Unraveling details of ionization and structure within such networks defines an important analytical challenge that requires the extension of current methodologies. ...
Shokri Alireza - - 2012
Nature employs flexible molecules to bind anions in a variety of physiologically important processes whereas supramolecular chemists have been designing rigid substrates that minimize or eliminate intramolecular hydro-gen bond interactions to carry out anion recognition. Herein, the association of a flexible polyhydroxy alkane with chloride ion is described and the ...
Van de Louw Andry - - 2012
ABSTRACT: INTRODUCTION: Hemorrhagic shock induced O2 deficit triggers inflammation and multiple organ failure (MOF). Endogenous H2S has been proposed to be involved in MOF since plasma H2S concentration appears to increase in various shocks and predict mortality. We tested the hypothesis that H2S increases in a model of hemorrhagic shock ...
Barea R - - 2012
The lipid content and fatty acid (FA) profile in pig tissues are strongly influenced by genotype and nutrient supply, with implications in meat quality. The de novo lipid synthesis and pattern of FA unsaturation could be an important cause of variation in the overall efficiency of energy utilization among breeds. ...
Wolffs Martin - - 2012
The self-assembly of two enantiomerically pure hexa(oligo (p-phenylene vinylene))-substituted benzenes having 24 stereocenters was studied in pure methylcyclohexane (MCH) and in a mixture of MCH/toluene (4:1). Irrespective of the solvent a cooperative supramolecular polymerization mechanism was determined for these star-shaped molecules by using temperature-dependent CD and UV/Vis spectroscopy. Quite remarkably, ...
Nie Kun - - 2012
A series of neutral lanthanide alkoxides supported by an amine-bridged bis(phenolate) ligand were synthesized, and their catalytic behaviors for the polymerization of rac-lactide (LA) and rac-β-butyrolactone (BBL) were explored. The reactions of (C(5)H(5))(3)Ln(THF) with amine-bridged bis(phenol) LH(2) [L = Me(2)NCH(2)CH(2)N{CH(2)-(2-OC(6)H(2)Bu(t)(2)-3,5)}(2)] in a 1:1 molar ratio in THF for 1 h ...
Vesikari Timo T Vaccine Research Center; University of Tampere, Medical School/FM3; Tampere, Finland. - - 2012
Effective vaccines offering broad protection to toddlers, who are at high risk for invasive meningococcal disease, are needed. Here, the immunogenicity, safety and antibody persistence of the tetravalent meningococcal ACWY tetanus toxoid conjugate vaccine (MenACWY-TT) were evaluated in toddlers. Healthy participants aged 12 to 23 mo (n = 304) were ...
Barrio-Real Laura L Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, - - 2012
Guanine nucleotide exchange factors (GEFs) that promote GTP loading onto the guanosine triphosphatases (GTPases) Rho and Rac are prominent players in cancer progression. Recent studies have highlighted the relevance of several GEFs, including the phosphatidylinositol 3,4,5-trisphosphate Rac exchangers P-Rex1 and P-Rex2a, in breast tumorigenesis. New evidence suggests that the exchange ...
Sarangarm Preeyaporn - - 2012
Many patients experience adverse events after discharge; numerous are medication related and preventable. The objective of this study is to evaluate the impact of pharmacist medication counseling and disease education at discharge. Pharmacist Assisting at Routine Medical Discharge is a prospective study of English- or Spanish-speaking adults discharged from internal ...
Shen Jenny I JI Division of Nephrology, Stanford University School of Medicine, 780 Welch Road, Suite 106, Palo Alto, California 94305, USA. - - 2013
Switching from peritoneal dialysis (PD) to hemodialysis (HD) is undesirable, because of complications from temporary vascular access, disruption of daily routine, and higher costs. Little is known about the role that social factors play in technique failure. We followed for 3 years a nationally representative cohort of US patients who ...
Shao Kaifeng K Institute for Neurophysiology, Medical Center, University of Cologne, Cologne, - - 2013
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is an epigenetic phenomenon. It has been suggested that iPSC retain some tissue-specific memory whereas little is known about interindividual epigenetic variation. We have reprogrammed mesenchymal stromal cells from human bone marrow (iP-MSC) and compared their DNA methylation profiles with ...
Fernandes Antony E - - 2012
Polymer brushes (PBs) have been used as supports for the immobilization of palladium complexes on silicon surfaces. The polymers were grown by surface-initiated atom-transfer radical polymerization (SI-ATRP) and postdecorated with dipyridylamine (dpa) ligands. The pendant dpa units were in turn complexed with [Pd(OAc)(2) ] to afford hybrid catalytic surfaces. A ...
Papiernik Sharon K - - 2012
Saflufenacil partitioning and dissipation was evaluated in soils from an eroded prairie landscape to provide information on its expected environmental fate. Saflufenacil Kd values followed trends in soil organic carbon content. In surface soils, Kd values ranged from 0.05 to 0.2 L kg-1 in the depositional lower slope and from ...
de la Fuente Concha - - 2012
Hepatitis C virus (HCV)/human immunodefficiency virus (HIV) coinfection is a major health problem, affecting mostly to individuals with exposure to blood products, as hemophiliacs or intravenous drug users, or those exposed to high-risk sexual practices. Genotyping of interleukin 28B (IL-28B) rs12979860 polymorphism is a useful tool for guiding therapeutic decisions ...
Addis Maria - - 2012
Genetic testing of myotonic dystrophy type 1 (DM1) is very important because it enables the diagnosis and indicates about the severity of the disease. Mutation analysis is based on the detection of the number of CTG triplets in the 3' untranslated region of the myotonic dystrophy protein kinase (DMPK) gene. ...
Chu Wen-Ting - - 2012
Dihydropteroate synthase (DHPS) is essential for the folic acid biosynthetic pathway in prokaryotes; the mutation forms for DHPS are found to be relative to the urgent drug resistance problems. In our study, the Bacillus anthracis DHPS (BaDHPS) was selected for molecular dynamics and binding free energy studies to investigate the ...
Upadhyaya Giridhar - - 2012
Terminal electron accepting process (TEAP) zones developed when a simulated groundwater containing dissolved oxygen (DO), nitrate, arsenate, and sulfate was treated in a fixed-bed bioreactor system consisting of two reactors (reactors A and B) in series. When the reactors were operated with an empty bed contact time (EBCT) of 20 ...
Standen Patricia E - - 2012
The addition of allyl magnesium and allyl indium reagents to a key TBS protected norbornenyl building block, synthesised in 6-steps from commercially available 1,1-dimethoxy-2,3,4,5-tetrachlorocyclopentadiene, has been achieved providing the syn addition products with high diastereoselectivity. The subsequent exposure of the addition products to metathesis conditions, in the presence of ethene, ...
Kurkov Sergey V - - 2012
Cyclodextrins are used increasingly to formulate otherwise poorly soluble molecules for clinical use. Cyclodextrins, such as 2-hydroxypropyl-β-cyclodextrin (HPβCD) and sulfobutylether β-cyclodextrin (SBEβCD), are found in marketed parenteral drug formulations. Depending upon the relative affinities of a coadministered medication for cyclodextrin and plasma proteins, complexation with HPβCD or SBEβCD may alter ...
Cahill Karyn B KB Department of Molecular, Cellular and Biomedical Sciences University of New Hampshire, Durham, New Hampshire 03824, - - 2012
The 11 families of the Class I cyclic nucleotide phosphodiesterases (PDEs) are critical for regulation of cyclic nucleotide signaling. PDE5 (important in regulating vascular smooth muscle contraction) and PDE6 (responsible for regulating visual transduction in vertebrate photoreceptors) are structurally similar but have several functional differences whose structural basis is poorly ...
Meynaar I A - - 2012
BACKGROUND: To study long-term survival in patients treated in the ICU and who survive to hospital discharge. METHODS:Single center retrospective cohort study of patients admitted to a mixed intensivist-led 10 bed ICU in a teaching hospital between 2004 and 2009 and discharged alive from the hospital with complete follow-up until ...
Serocki G - - 2012
BACKGROUND: Recently, indirect videolaryngoscopes have become increasingly important devices in difficult airway management. The aim of the present study was to investigate laryngoscopic view and intubation success using the new C-MAC® D-Blade in comparison to the established GlideScope® videolaryngoscope and conventional direct laryngoscopy in a randomized controlled trial. METHODS: Ninety-six ...
Müller Carola J - - 2012
A new ternary orthorhombic compound with the formula Cu(5+δ)In(2+x)Sb(2-x), crystallizing in the space group Cmc2(1) with 36 atoms per unit cell [a = 10.1813(4) Å, b = 8.4562(4) Å, c = 7.3774(2) Å, Z = 4], has been synthesized by conventional high-temperature methods. The structure is based on the B8 ...
Grundy Emily - - 2012
To investigate whether number of children and, among parents, having a daughter is associated with older people's likelihood of at least weekly face-to-face social contact and later receipt of help if needed. Multivariate analysis of data from Waves 1 and 2 of the English Longitudinal Study of Ageing (ELSA). Older ...
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