Search Results
Results 501 - 550 of 3179
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Turan Nedim - - 2012
OBJECTIVE:To report a case of nephrotic syndrome (NS) induced by both sunitinib and sorafenib therapy.CASE SUMMARY:A 61-year-old woman with metastatic gastrointestinal stromal tumor (GIST) presented with NS and hypertension following therapy with sunitinib 400 mg/day. Because of grade 3 toxicity, the drug was discontinued. After sunitinib discontinuation, NS and hypertension ...
Powell Kimberley J - - 2012
The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (), and its proposed biosynthetic precursors ( and ) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates ...
Honarvar Behnam - - 2012
Objective: Vaccination provides the most effective protection against maternal, fetal and neonatal complications of influenza infection. This study aimed to determine the uptake rate of influenza vaccination including 2009 pandemic H1N1 influenza and seasonal influenza vaccination and the reasons for acceptance or rejection among pregnant women.   Method: This questionnaire ...
Hu Chia-Wei - - 2012
Rhodopseudomonas palustris (R. palustris) is a purple nonsulfur anoxygenic phototrophic bacterium with metabolic versatility and able to grow under photoheterotrophic and chemoheterotrophic states. It has the ability in carbon management, carbon recycling, hydrogen generation, and lipid production; therefore it has the potential for bioenergy production and biodegradation. This study is ...
Cobo Marién - - 2012
Multiple sclerosis (MS) is a severe debilitating disorder characterised by progressive demyelination and axonal damage of the central nervous system (CNS). Current therapies for MS inhibit the immune response and demonstrate reasonable benefits if applied during the early phase of relapsing-remitting MS (RRMS) while there are no treatments for patients ...
Schneider Susanne A - - 2012
BACKGROUND: The UPDRS is the most widely used rating scale for Parkinson's disease (PD). However, subtle features of early disease stages may be missed. METHODS: We studied 25 early PD patients using a newly compiled battery of motor tests focusing on subtle motor features. Focal dystonia patients (n = 31) ...
Desai Atman - - 2012
Purpose:  Interictal positron emission tomography (PET) and ictal subtraction single photon emission computed tomography (SPECT) of the brain have been shown to be valuable tests in the presurgical evaluation of epilepsy. To determine the relative utility of these methods in the localization of seizure foci, we compared interictal PET and ...
Mattey Derek L - - 2012
ABSTRACT: INTRODUCTION: Matrix metalloproteinases (MMPs) are implicated in the destruction of the joint and have been shown to be strongly associated with inflammation in rheumatoid arthritis (RA). Circulating MMPs have also been associated with cardiovascular disease in the general population, and are predictive of cardiovascular mortality. The purpose of the ...
Yao Jun - - 2012
Transparent electronic memory would be useful in integrated transparent electronics. However, achieving such transparency produces limits in material composition, and hence, hinders processing and device performance. Here we present a route to fabricate highly transparent memory using SiO(x) as the active material and indium tin oxide or graphene as the ...
Hsu Chiajen - - 2012
Au-PtCu core-shell nanoparticles were successfully synthesized via galvanic replacement of Cu by Pt on hollow Au nano-spheres. Characterizations of the nanoparticles were conducted by X-ray diffraction (XRD), transmission electron microscopy (TEM), and electrochemical measurements. Results indicate 2-2.5 times higher specific activity and mass activity of the Au-PtCu catalysts than commercial ...
Alcaraz Antonia - - 2012
Human amniotic epithelial cells (hAECs) have been the object of intense research due to its potential therapeutic use. In this paper, we present molecular evidence of a bona fide epithelial to mesenchymal transition (EMT) undergone by hAECs. Amniotic Membrane (AM) hAECs showed the presence of typical epithelial markers such as ...
Sharif Mohammad Owaise - - 2012
Objective :  To explore the experiences of children and young people with cleft lip and/or palate (CL/P) in relation to being treated for and living with this condition. Design :  A systematic review of qualitative research. Electronic databases and hand-searching were employed to identify relevant studies. The review centered on ...
Dosset Magalie - - 2012
PURPOSE: To evaluate CD4+ helper functions and antitumor effect of promiscuous universal cancer peptides (UCP) derived from telomerase reverse transcriptase (TERT). EXPERIMENTAL DESIGN: To evaluate the widespread immunogenicity of UCPs in human, spontaneous T cell responses against UCPs were measured in various types of cancer using T cell proliferation and ...
Yan Chuan - - 2012
Several studies show that climatic (extrinsic) factors can interact with density-dependent (intrinsic) factors to alter long-term population dynamics, yet there is a surprising lack of investigations of how anthropogenic disturbance modifies such dynamics. Such interactions could be especially important in agricultural systems subject to climate change. We investigated the effects ...
Thilakarathne Vindya K - - 2012
Protein chemical modification was introduced here to tune protein/polymer interactions in a systematic manner, where met-hemoglobin (Hb) and poly(acrylic acid) (PAA) served as a model system. Under similar conditions of pH and ionic strength, influence of protein charge on Hb/PAA interaction was studied using chemically modified Hb and isothermal titration ...
Dumas Orianne - - 2012
OBJECTIVE: Cleaning products may cause work-related asthma, but information regarding the specific exposures involved is scarce. We aimed to determine the associations between asthma and occupational exposure to cleaning agents in hospital workers. METHODS: Analyses were conducted in 179 (136 women) hospital workers and a reference population of 545 subjects ...
Liu Weihui - - 2012
Breast cancer resistance protein 1 (BCRP1/ABCG2) is used to identify the side population (SP) within a population of cells, which is enriched for stem and progenitor cells in different tissues. Here, we investigated the role of extracellular-regulated kinase (ERK) 1/2 in the signaling mechanisms underlying ischemic/hypoxic conditions in kidney SP ...
Jakobsen Lars - - 2012
BACKGROUND: THE ASSOCIATION BETWEEN LOW SOCIOECONOMIC STATUS (SES) AND HIGH MORTALITY FROM CORONARY HEART DISEASE IS WELL-KNOWN. HOWEVER, THE ROLE OF SES IN RELATION TO THE CLINICAL OUTCOME AFTER PRIMARY PERCUTANEOUS CORONARY INTERVENTION REMAINS POORLY UNDERSTOOD.METHODS AND RESULTS: WE STUDIED 7385 PATIENTS TREATED WITH PRIMARY PERCUTANEOUS CORONARY INTERVENTION. PARTICIPANTS WERE ...
Bohle D Scott - - 2012
The facile axial ligand exchange properties of gallium(III) protoporphyrin IX in methanol solution were utilized to explore self-association interactions by NMR techniques. Structural changes were observed, as well as competitive behavior with the ligands acetate and fluoride, which differed from that seen with the synthetic analogue gallium(III) octaethylporphyrin which lacks ...
Wilson Julie - - 2012
Collagen peptides are analysed using a low-cost high-throughput method for assessing deamidation using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). For each chosen peptide, the theoretical distribution is calculated and the measured distribution for each sample compared with this to determine the extent of glutamine deamidation. The deamidation of glutamine (Q) ...
Cheng Tain-Junn - - 2012
BACKGROUND AND PURPOSE: Little is known about the comparability of stroke subtype mortality across states. We conducted a -cross--sectional descriptive study to examine state differences in the reporting of "unspecified stroke" on death certificates in the United States. METHODS: The number of deaths from different subtypes of stroke in each ...
Rodríguez Carlos - - 2012
The use of sludge (biosolids) in land application may contribute to the spread of organic micropollutants, as wastewater treatments do not completely remove these compounds. Therefore, the development of alternative strategies for sludge treatment is a matter of recent concern. The elimination of pharmaceuticals at pre-existent concentrations from sewage sludge ...
Yoneshiro T - - 2012
Background:Brown adipose tissue (BAT) is involved in the regulation of whole-body energy expenditure and adiposity. The activity and prevalence of BAT decrease with age in humans.Objective:To examine the effects of single nucleotide polymorphisms of the genes for uncoupling protein 1 (UCP1) and β3-adrenergic receptor (β3AR), key molecules of BAT thermogenesis, ...
Kamata Noriyuki - - 2012
We investigated the effect of advance information about the sequence of a to-be-signaled motor response on corticospinal excitability during the foreperiod in healthy humans. Advance information about the sequence of a to-be-signaled motor response was provided by a precue signal 600 ms before a response signal during a warned choice reaction ...
Barbasiewicz Michał - - 2012
Coordination, not insertion: New ruthenium benzylidenes with a chelating halogen atom were easily prepared and showed excellent stability and activity as metathesis catalysts. Structure-activity studies reveal that strength of the ruthenium-halogen interaction can be tuned across a wide range to set up a family of latent to active catalysts.
Quan Li - - 2012
Luminous boron: New 1,8-naphthyridine-BF(2) complexes with strong emissions both in solution and in the solid state were developed. Aggregation-induced blueshifts of emissions in DMSO/water mixtures and solvent-influenced luminescence in crystalline states have been observed and discussed.
Boyden Jo - - 2012
This paper discusses the eradication challenges of female circumcision in Ethiopia. It argues that despite an overall decline in the practice nationally, eradication efforts have caused significant quandaries for girls and their families. The most common justification by far for its continuance is that circumcision confirms a girl's social place ...
Ito Matthew K - - 2012
OBJECTIVE:To evaluate current approaches and explore emerging research related to dyslipidemia management.DATA SOURCES:MEDLINE (2004-April 2012) was searched for randomized controlled trials using the terms dyslipidemia and lipid-lowering therapy or statin (>1000 hits). Separate searches (MEDLINE, Google) identified meta-analyses (2010-2011), disease prevalence statistics, and current consensus guidelines (2004-July 2011). Additional references ...
Macaodha Domhnall - - 2012
Co-immobilisation approaches for preparation of glucose-oxidising films of [Os(2,2'-bipyridine)(2)(poly-vinylimidazole)(10)Cl] and glucose oxidase on glassy carbon electrodes are compared. Electrodes prepared by crosslinking using glutaraldehyde vapour, without and with a NaBH(4) reduction, provide higher glucose oxidation current than those prepared using a well-established diepoxide method. Addition of multi walled carbon nanotubes ...
Al Moustafa Ala-Eddin - - 2012
We recently conducted several studies regarding the presence of high-risk HPVs in human cervical, colorectal and breast cancers in the Syrian population. Herein, we report that high-risk HPVs type 16, 18, 33, 45, 51, 52 and 58 are frequently present in colorectal cancer in this population. Therefore and based on ...
Wang Bing-Song - - 2012
Purpose: To evaluate dynamic changes in anterior segment morphology during the Valsalva maneuver with ultrasound biomicroscopy (UBM). Methods: This was a prospective observational study. A group of patients with narrow angles and a group of normal subjects were recruited. The anterior segment of subjects was imaged and quantitatively analyzed using ...
Mendonca Goncalo V - - 2012
As with water ingestion, the activation of the muscle metaboreflex leads to heightened muscle sympathetic nerve activity. Thus, we hypothesized that water ingestion might enhance the pressor effect of the muscle metaboreflex activation. We examined the effect of water ingestion (50 vs. 500 mL) on the cardiovascular and autonomic responses to ...
Uitz P M - - 2012
Haemochromatosis may impair the function of endocrine organs, amongst others the pituitary gland. It was the aim of this study to determine pituitary function in adult patients with genetically defined hereditary haemochromatosis in a prospective diagnostic study using a standardised stimulation test. Therefore, 22 patients (7 females, 15 males; age ...
Choi Eui-Young - - 2012
BACKGROUND: -Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) is associated with clinically overt heart failure (HF). However, whether it provides additive prognostic information for incident HF beyond traditional risk factors and the left ventricular (LV) mass index among multi-ethnic asymptomatic individuals has not yet been determined. We studied the associations of ...
Borowski Andrzej F - - 2012
A series of anthracene and acridine derivatives were hydrogenated under mild reaction conditions (80 °C, 3 bar of H(2)) using the bis(dihydrogen) complex [RuH(2)(η(2)-H(2))(2){P(C(6)H(11))(3)}(2)] () as a catalyst precursor. The influence of a methyl substituent on the substrate was studied. In all our systems, hydrogenation was only observed at the ...
Folgar Francisco A - - 2012
PURPOSE: To determine the relative ability of time domain (TD) optical coherence tomography (OCT) compared with spectral domain (SD) OCT to assess vitreoretinal interface abnormalities and pharmacologic treatment of symptomatic vitreomacular adhesion (VMA)/traction (VMT) with or without full-thickness macular hole (FTMH), and the reproducibility of trained readers' evaluation of these ...
Puell Maria C - - 2012
PURPOSE: To determine photopic and mesopic distance high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD). METHODS: Measurements were made in 22 subjects with early AMD and 28 healthy control subjects. Inclusion criteria included a photopic HC-VA of 20/25 or better. Distance ...
Murphy Andrew J - - 2012
Raising HDL levels is proposed as an attractive target to treat cardiovascular disease. However, a number of clinical studies examining the effect of HDL raising therapies have been prematurely halted due to futility. Therefore there is a need for alternative therapies. Infusion of reconstituted HDL (rHDL) particles is still considered ...
Lai Long-Li - - 2012
Two triazine-based unconventional dendrimers were prepared and characterized by (1) H and (13) C NMR spectroscopy, mass spectrometry, and elemental analysis. Differential scanning calorimetry, polarizing microscopy, and powder XRD studies showed that these dendrimers display columnar liquid-crystalline phases during thermal treatment. This is ascribable to breaking of their C(2) symmetry. The ...
Sarkis Joe - - 2012
Dystrophin is an essential part of a membrane protein complex that provides flexible support to muscle fiber membranes. Loss of dystrophin function leads to membrane fragility and muscle-wasting disease. Given the importance of cytoskeletal interactions in strengthening the sarcolemma, we have focused on actin-binding domain 2 of human dystrophin, constituted ...
Hsieh Cheng-Yang - - 2012
Purpose:  Patients with epilepsy have higher stroke-related morbidity and mortality, leading to the suspicion that the increased stroke events may be associated with antiepileptic drug (AED) exposure. We evaluated the comparative risk of stroke in adult patients with epilepsy receiving phenytoin (PHT), valproic acid (VPA), or carbamazepine (CBZ) to help ...
Miura Tomoya - - 2012
A copper(I)/2,2'-bipyridyl complex catalyzes an amination reaction of silyl ketene acetals with N-chloroamines, presenting a new preparative method of α-amino esters.
Li Chen - - 2012
Backgrounds: In China, chronic periodontitis is common in patients with type 2 diabetes mellitus. The purpose of this study was to identify the sociodemographic characteristics associated with such patients and to assess the periodontal health status and subgingival microbiota of these patients with chronic periodontitis and type 2 diabetes mellitus ...
Zhou Changhua - - 2012
In this paper, we have demonstrated a novel and simple way to prepare transparent composite fluorescent films by using poly (acrylic acid) co-polymer as a matrix and silica coated photoluminescence (PL) quantum dots (QDs) as light-emitting materials. The strategies include preparing aqueous amphiphilic oligomer (polymaleic acid n-hexadecanol ester, PMAH) modified ...
Muratsugu Satoshi - - 2012
Selective catalysis is critical for the development of green chemical processes, and natural enzymes that possess specialized three-dimensional reaction pockets with catalytically active sites represent the most sophisticated systems for selective catalysis. A reaction space in an enzyme consists of an active metal center, functional groups for molecular recognition (such ...
Giese-Davis Janine - - 2012
ABSTRACT: BACKGROUND: Very few studies examine the longitudinal prevalence of problems and the awareness or use of clinical programs by patients who report these problems. Of the studies that examine age, gender and marital status as predictors of a range of patient outcomes, none examines the interactions between these demographic ...
Batista Júnior Miguel Luiz - - 2012
Cancer cachexia induces loss of fat mass that accounts for a large part of the dramatic weight loss observed both in humans and in animal models; however literature does not provide consistent information regarding the set point of weight loss and how the different visceral adipose tissue depots contribute to ...
Jewell April D - - 2012
Atomic and molecular self-assembly are important phenomena that underpin many important technologies. Typically, thermally enabled diffusion allows a system to sample many areas of configurational space, and ordered assemblies evolve that optimize interactions between species. Herein we describe a system in which the diffusion is quantum tunneling in nature and ...
Flaker Greg C - - 2012
BACKGROUND AND PURPOSE: Apixaban reduces stroke with comparable bleeding risks when compared with aspirin in patients with atrial fibrillation who are unsuitable for vitamin k antagonist therapy. This analysis explores patterns of bleeding and defines bleeding risks based on stroke risk with apixaban and aspirin. METHODS: The Apixaban versus Acetylsalicylic ...
Nimse Satish Balasaheb - - 2012
The functionalized calixarene derivatives exhibit remarkable properties towards organic and bioorganic molecules. However, the ability of calixarene derivatives to form stable complexes with biomolecules allows them to be applied for the development of biosensors and in the field of biology, biotechnology, and drug discovery. The applications of the functionalized calixarenes ...
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