Search Results
Results 451 - 500 of 3178
< 5 6 7 8 9 10 11 12 13 14 15 >
Wang Ruhung - - 2012
Abstract Poloxamers (known by the trade name Pluronic(®)) are triblock copolymer surfactants that contain two polyethylene glycol blocks and one polypropylene glycol block of various sizes. Poloxamers are widely used as nanoparticle dispersants for nanotoxicity studies wherein nanoparticles are sonicated with a dispersant to prepare suspensions. It is known that ...
Koenig Thomas - - 2012
Spectroscopic x-ray imaging by means of photon counting detectors has received growing interest during the past years. Critical to the image quality of such devices is their pixel pitch and the sensor material employed. This paper describes the imaging properties of Medipix2 MXR multi-chip assemblies bump bonded to 1 mm thick ...
Congyu Ke - - 2012
An approach for re-folding denatured proteins during proteome research by protein folding liquid chromatography (PFLC) is presented. Standard protein, α-chymotrypsin (α-Chy), was selected as a model protein and hydrophobic interaction chromatography was performed as a typical PFLC; the three different α-Chy states - urea-denatured (U state), its folded intermediates (M ...
Barford William - - 2012
We present a first principles theory of exciton diffusion in conformationally disordered conjugated polymers. Central to our theory is that exciton transfer occurs from vibrationally relaxed states (VRS) to local exciton ground states (LEGS). LEGSs are determined by the diagonal and off-diagonal disorder induced by density and torsional fluctuations, while ...
Sahni Vasav - - 2012
Spiders' cobwebs ensnare both walking and flying prey. While the scaffolding silk can entangle flying insects, gumfoot silk threads pull walking prey off the ground and into the web. Therefore, scaffolding silk needs to withstand the impact of the prey, whereas gumfoot silk needs to easily detach from the substrate ...
Virani Karim - - 2012
Background: Frontotemporal dementia (FTD) is a neurodegenerative disorder resulting in social-cognitive deficits partially attributed to abnormalities processing social cues, such as facial expressions. However, to our knowledge, the functional neuroanatomy of deficient social cue processing in individuals with FTD has not been examined. The objective of this study was to ...
Kayhan Emine - - 2012
Low-layered, transparent graphene is accessible by a chemical vapor deposition (CVD) technique on a Ni-catalyst layer, which is deposited on a <100> silicon substrate. The number of graphene layers on the substrate is controlled by the grain boundaries in the Ni-catalyst layer and can be studied by micro Raman analysis. ...
Ma Terry King-wing TK Division of Nephrology, Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong SAR, PR - - 2013
Peritoneal dialysis-associated peritonitis secondary to Campylobacter organisms is uncommon. Few studies have assessed either treatment or clinical outcomes. We reviewed all Campylobacter peritonitis episodes occurring in a single dialysis unit from 1994 to 2011. During the study period, 12 episodes of Campylobacter peritonitis (0.45% of all peritonitis episodes) were recorded. ...
Amdekar Sarika - - 2012
In view of well-established immunomodulatory properties of Lactobacillus, present investigation was carried out to evaluate antioxidant and anti-inflammatory potential of Lactobacillus casei and Lactobacillus acidophilus, against inflammatory pathway and oxidative stress developed in an experimental model of arthritis. Collagen-induced arthritis (CIA) model was used. Oral administration of L. casei, L. ...
Greco Camila Coelho - - 2012
The purpose of this study was to analyze the effect of recovery type (passive vs. active) during prolonged intermittent exercises on the blood lactate concentration (MLSS) and work rate (MLSS(wint)) at maximal lactate steady state. Nineteen male trained cyclists were divided into 2 groups for the determination of MLSS(wint) using ...
Benzaïd Ismahene - - 2012
PURPOSE: Nitrogen-containing bisphosphonates (N-BPs) such as zoledronate (ZOL) and risedronate (RIS) exhibit antitumor effects. They block the activity of farnesyl pyrophosphate synthase in the mevalonate pathway, leading to intracellular accumulation of mevalonate metabolites (IPP/ApppI) which are recognized as tumor phosphoantigens by Vγ9Vδ2T cells. However, mechanisms responsible for Vγ9Vδ2T-cell recognition of ...
Bhandavat Romil - - 2012
We study the electrochemical behavior of precursor-derived siliconboron carbonitride (Si(B)CN) ceramic and Si(B)CN coated-multi-walled carbon nanotube (CNT) composite as a lithium-ion battery anode. Reversible capacity of Si(B)CN was observed to be 138 mAh/g after 30 cycles, which is four times that of SiCN (~25 mAh/g) processed under similar conditions, while ...
Godfrey Laura M - - 2012
OBJECTIVE:To evaluate the teratogenic potential of statins in women of childbearing age.DATA SOURCES:A PubMed search (1980-September 2012) was performed using the search terms statin and pregnancy, then repeated using statin and teratogenicity. Results were limited to articles published in English reporting on use of statins in humans.STUDY SELECTION AND DATA ...
Kaul Vandana V Immunology Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, - - 2012
Mycobacterium tuberculosis, the causative agent of tuberculosis, resides and replicates within susceptible hosts by inhibiting host antimicrobial mechanisms. Prostaglandin E(2) (PGE(2)), produced by M. tuberculosis-infected macrophages, exerts a variety of immunomodulatory functions via 4 receptors (EP1-EP4), each mediating distinct PGE(2) functions. Here, we show that M. tuberculosis infection selectively upregulates ...
Parolo Claudio - - 2012
In this review we discuss how nanomaterials can be integrated in diagnostic paper-based biosensors for the detection of proteins, nucleic acids and cells. In particular first the different types and properties of paper-based nanobiosensors and nanomaterials are briefly explained. Then several examples of their application in diagnostics of several biomarkers ...
Mednick Lauren - - 2012
Objective :  To describe and compare the causal beliefs associated with cleft lips and/or palates across several different countries. Design :  Cross-sectional survey. Setting :  Operation Smile surgery screenings in six developing countries. Participants :  Two hundred seventy-nine adult patients and parents of children with cleft lips and/or palates in ...
Smulders Maarten M J - - 2012
Over the last two decades the field of metallosupramolecular self-assembly has emerged as a promising research area for the development of intricate, three-dimensional structures of increasing complexity and functionality. The advent of this area of research has strongly benefited from design principles that considered the ligand geometry and metal coordination ...
Radvanyi Laszlo G LG Departments of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. - - 2012
Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) is a promising treatment for metastatic melanoma unresponsive to conventional therapies. We report here on the results of an ongoing phase II clinical trial testing the efficacy of ACT using TIL in patients with metastatic melanoma and the association of specific ...
Eden Alvin N - - 2012
Iron deficiency anemia (IDA) continues to be overwhelmingly the leading cause of anemia in early childhood and a global public health challenge. Although there has been a significant decrease in the frequency of IDA and iron deficiency (ID) in infants and toddlers in recent years in the United States, ID ...
de Betue Carlijn Ti - - 2012
ABSTRACT: INTRODUCTION: Hyperglycemia in children after cardiac surgery can be treated with intensive insulin therapy, but hypoglycemia is a potential serious side effect. The aim of this study was to investigate the effects of reducing glucose intake below standard intakes to prevent hyperglycemia, on blood glucose concentrations, glucose kinetics and ...
Forehand Christy C - - 2012
OBJECTIVE:To evaluate whether there is a relationship between antimicrobial therapy and the development of thrombocytosis.DATA SOURCES:Literature was accessed through EMBASE (1977-June 2012) and MEDLINE (1977-June 2012) using the terms thrombocytosis and antimicrobial. In addition, reference citations from publications identified were reviewed.STUDY SELECTION AND DATA EXTRACTION:All English-language publications identified were evaluated. ...
Laurichesse Henri H CHU Clermont-Ferrand, INSERM/Centre d'Investigation Clinique (CIC) 501, UMR 1019 INRA-UdA, Univ-Clermont-1, Clermont-Ferrand, - - 2012
In adults with a tetanus-prone injury, combined vaccines such as Tdap-IPV (REPEVAX®) can boost immunity against several diseases simultaneously. This Phase IIIb, parallel-group, open-label trial compared antibody responses to Tdap-IPV and tetanus monovalent vaccine (TMV; Vaccin Tétanique Pasteur® or Tetavax®) against tetanus toxoid 10 and 28 d post-vaccination. Between July ...
West Patrick J - - 2012
The syntheses of trans-[Os(C≡C-4-C(6)H(4)X)Cl(dppe)(2)] [X = Br (3), I (4)], trans-[Os(C≡C-4-C(6)H(4)X)(NH(3))(dppe)(2)](PF(6)) [X = H (5(PF(6))), I (6(PF(6)))], and trans-[Os(C≡C-4-C(6)H(4)X)(C≡C-4-C(6)H(4)Y)(dppe)(2)] [X = Y = H (7), X = I, Y = C≡CSiPr(i)(3) (8)] are reported, together with improved syntheses of cis-[OsCl(2)(dppe)(2)] (cis-1), trans-[Os(C≡CPh)Cl(dppe)(2)] (2), and trans-[Ru(C≡C-4-C(6)H(4)I)(NH(3))(dppe)(2)](PF(6)) (9(PF(6))) (the last-mentioned direct from ...
Clarke Brian D - - 2012
Abstract RNA interference (RNAi) is a powerful, sequence specific, and long-lasting method of gene knockdown, and can be elicited by the expression of short-hairpin RNA (shRNA) molecules driven via polymerase III type 3 promoters from a DNA vector or transgene. To further develop RNAi as a tool in zebrafish, we ...
Rackwitz Sergej - - 2012
The vibrational properties of the cationic spin crossover (SCO) coordination polymers [{Fe(4-amino-1,2,4-triazole)(3)}(+2)](n) containing the anions chlorine, methanosulfonate and 1-naphthalenesulfonate have been studied via nuclear inelastic scattering of synchrotron radiation (NIS) as well as by Raman spectroscopy. Although the different anions have a strong influence on the spin crossover temperature, they ...
Barreira João C M - - 2012
Mushrooms are becoming relevant foods due to their nutritional, gastronomic and pharmacological properties, namely antioxidant, antitumor and antimicrobial properties. However, despite several mushroom species have been chemically characterized, the evaluation of triacylglycerol (TAG) profile remained nearly discarded. Since TAG was formerly used to assess the authentication of highly valued commercial ...
Cai Zhongyu - - 2012
An improved convective self-assembly method was developed to fabricate crack-free colloidal crystal heterostructure. A composite opaline heterostructure composed of polystyrene (PS) colloids was firstly fabricated. Subsequent calcination of the opaline heterostructure led to the formation of inverse opaline heterostructure composed of SiO2 or TiO2. Both opaline and inverse opaline heterostructures ...
Adeloye Davies - - 2012
Introduction Road traffic injuries (RTIs) and attendant fatalities on Nigerian roads have been on an increasing trend over the past three decades. Mortality from RTIs in Nigeria is estimated to be 162 deaths/100,000 population. This study aims to compare and identify best prehospital trauma care practices in Nigeria and some ...
Jessen Lene L Division of Endocrinology, University of Cincinnati, Cincinnati, OH 45237, - - 2012
Administration of the glucagon-like peptide-1 (GLP-1) receptor agonists GLP-1 and exendin-4 (Ex-4) directly into the central nervous system decreases food intake. But although Ex-4 potently suppresses food intake after peripheral administration, the effects of parenteral GLP-1 are variable and not as strong. A plausible explanation for these effects is the ...
Zandomeneghi Giorgia - - 2012
While structural information on biomolecules is mainly obtained from purified in-vitro samples, NMR can also be applied in the context of entire cells or organisms. The present study describes maturation processes in living Salmonella enterica, a prevalent cause for human gastroenteritis. In our physiological study we follow the composition of ...
Turan Nedim - - 2012
OBJECTIVE:To report a case of nephrotic syndrome (NS) induced by both sunitinib and sorafenib therapy.CASE SUMMARY:A 61-year-old woman with metastatic gastrointestinal stromal tumor (GIST) presented with NS and hypertension following therapy with sunitinib 400 mg/day. Because of grade 3 toxicity, the drug was discontinued. After sunitinib discontinuation, NS and hypertension ...
Powell Kimberley J - - 2012
The sacoglossan mollusc-derived metabolite, tridachiahydropyrone (), and its proposed biosynthetic precursors ( and ) form part of a complex chemical defence system against predators and harmful UV light. Here, we provide supporting biophysical evidence that the metabolites become selectively localised at cell membranes and outline a binding scheme that accommodates ...
Honarvar Behnam B Community and Preventive Medicine, Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. - - 2012
Vaccination provides the most effective protection against maternal, fetal and neonatal complications of influenza infection. This study aimed to determine the uptake rate of influenza vaccination including 2009 pandemic H1N1 influenza and seasonal influenza vaccination and the reasons for acceptance or rejection among pregnant women. Mean age of the 416 ...
Hirose Misaki M Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, - - 2013
Vitamin D plays an important role in calcium homeostasis and is used to treat secondary hyperparathyroidism among dialysis patients. The biologic activity of vitamin D and its analogs is mediated by vitamin D receptor (VDR), which is distributed widely throughout the body. Recent papers have revealed that low vitamin D ...
Lété Bernard - - 2012
In a series of six experiments, the influence of frequency trajectory in visual word recognition was investigated. In Experiment 1, frequency trajectory was found to exert a strong and reliable influence on age of acquisition (AoA) ratings. In word reading (Experiment 2), lexical decision (Experiments 3 and 6), proper name ...
Macdonald Gordon A - - 2012
We demonstrate mapping of electrical properties of heterojunctions of a molecular semiconductor (copper phthalocyanine, CuPc) and a transparent conducting oxide (indium-tin oxide, ITO), on 20-500 nm length scales, using a conductive-probe atomic force microscopy (C-AFM) technique, Scanning Current Spectroscopy (SCS). SCS maps are generated for CuPc/ITO heterojunctions as a function ...
Liu Sha S Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People's Republic of - - 2012
Glycogen synthase kinase-3β (GSK3β) may play an important role in the brain of patients with major depressive disorder (MDD); therefore, we investigated whether the GSK3β gene is involved in the etiology of MDD and whether it affects MDD endophenotypes. Three single-nucleotide polymorphisms (SNPs) (rs6438552, rs7633279, and rs334558) were genotyped in ...
Grube Maike Miriam - - 2012
BACKGROUND AND PURPOSE: We aimed to analyze the association between patient socioeconomic status and functional impairment 3 months after ischemic stroke and to identify factors that influence this association. METHODS: Data were obtained from the Berlin Stroke Register, a network of 14 stroke units in Berlin. Ischemic stroke patients consecutively ...
Ren Zhi - - 2012
We describe a Pd-catalyzed site-selective functionalization of unactivated aliphatic C-H bonds, providing chemically differentiated 1,2-diols from mono-alcohol derivatives. The oxime was employed as both a directing group and an alcohol surrogate for this transformation. As demonstrated in a range of substrates, the C-H bonds α to the oxime group are ...
Pedraza Eileen - - 2012
Clinical islet transplantation has demonstrated success in treating type 1 diabetes. A current limitation is the intrahepatic portal vein transplant site, which is prone to mechanical stress and inflammation. Transplantation of pancreatic islets into alternative sites is preferable, but challenging, as it may require a three-dimensional vehicle to confer mechanical ...
Pavlov Vasile I - - 2012
Coagulation disorders and reperfusion of ischemic myocardium are major causes of morbidity and mortality. Lectin pathway initiation complexes are composed of multimolecular carbohydrate recognition subcomponents and 3 lectin pathway-specific serine proteases. We have recently shown that the lectin pathway-specific carbohydrate recognition subcomponent mannose-binding lectin plays an essential role in the ...
Sato Y - - 2012
What is known and Objective:  Pilocarpine, a muscarinic receptor agonist, has been used for the treatment of dry mouth. Salivary glands are supplied with nerve fibres that contain neuropeptides, such as substance P, calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP), which are important modulators of salivation. It is ...
Sutak Robert - - 2012
We investigated iron uptake mechanisms in five marine microalgae from different ecologically important phyla: the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana, the prasinophyceae Ostreococcus tauri and Micromonas pusilla, and the coccolithophore Emiliania huxleyi. Among these species, only the two diatoms were clearly able to reduce iron, via an inducible (P. ...
Liu P - - 2012
Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer stem cells (CSCs) are a key mediator of chemoresistance. We have reported that disulfiram (DS), an aldehyde dehydrogenase (ALDH) inhibitor, targets breast CSC-like cells. In this study, the effect of DS and combination of DS and gemcitabine (dFdC) on GBM ...
Ishida Akio - - 2012
Aims: Age-related change of ankle-brachial index (ABI) within the general population, especially <40 years, has not been determined in large population studies. We evaluated the value of the ABI by age- and sex-related differences in a screened cohort.Methods and results: The ABI was examined in 13,211 participants (aged 21-89 years) ...
Kontos Anthony P - - 2012
Mild traumatic brain injury (mTBI) has gained considerable notoriety during the past decade of conflict in Afghanistan and Iraq. However, the relationship between combat-related mTBI and residual mTBI symptoms, post-traumatic stress disorder (PTSD) symptoms, and neurocognitive deficits remains unclear. The purpose of the study was to compare residual mTBI and ...
Enkvist Erki - - 2012
Up-regulation of an acidophilic protein kinase, CK2, has been established in several types of cancer. This cognition has made CK2 an important target for drug development for cancer chemotherapy. The characterization of potential drug candidates, determination of the structure and clarification of the functions of CK2 could be facilitated by ...
Gloria Antonio - - 2012
The requirement of a multifunctional scaffold for tissue engineering capable to offer at the same time tunable structural properties and bioactive interface is still unpaired. Here we present three-dimensional biodegradable polymeric (PCL) scaffolds with controlled morphology, macro-, micro-, and nano-mechanical performances endowed with bioactive moieties (RGD peptides) at surface. Such ...
Friedenreich Christine Marthe - - 2012
Markers of insulin resistance such as the adiponectin:leptin ratio (A:L) and the homeostasis model assessment ratio (HOMA-IR) are associated with obesity and hyperinsulinemia, both established risk factors for endometrial cancer, and may therefore be informative regarding endometrial cancer risk. This study investigated the association between endometrial cancer risk and markers ...
Hu Lanhua - - 2012
Ferrate [Fe(VI); FeO42-] is an emerging oxidizing agent capable of controlling chemical and microbial water contaminants. Here, inactivation of MS2 coliphage by Fe(VI) was examined. The inactivation kinetics observed in individual batch experiments was well described by a Chick-Watson model with first-order dependences on disinfectant and infective phage concentrations. The ...
< 5 6 7 8 9 10 11 12 13 14 15 >