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Results 401 - 450 of 3887
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Sivaneswaran Shanti - - 2012
The State of New South Wales (NSW) in Australia has over half a century of experience with water fluoridation. Yass was the first town to be fluoridated in 1956 and Sydney in 1968, and by the late 1970s, approximately 90% of NSW was fluoridated. However, since then, there have been ...
van der Hoek Frouwien D - - 2012
: To compare components of health-related physical fitness between Dutch children with clinically diagnosed developmental coordination disorder (DCD) and typically developing children (TDC), and to examine associations between motor performance problems and components of health-related fitness in children with DCD. : A multicenter case-control study was used to compare health-related ...
Kee Ying Hwa - - 2012
We examined whether the momentary induction of state mindfulness benefited subsequent balance performance, taking into consideration the effects of dispositional mindfulness. We also tested whether our mindfulness induction, grounded in sustaining moment-to-moment attention, influenced the attentional focus strategies that were adopted by the participants during the balancing task. Balance performance ...
Yang Owen - - 2012
Laser speckle imaging (LSI) is a noninvasive optical imaging technique able to provide wide-field two-dimensional maps of moving particles. Raw laser speckle images are typically taken with a scientific-grade monochrome camera. We demonstrate that a digital single-lens reflex (dSLR) camera with a Bayer filter is able to provide similar sensitivity ...
Liu Ken - - 2012
The confinement of light within nanometer-scale regions may result in the significant enhancement of light-matter interactions. However, light confinement to nanometers is hindered by the diffraction limit of a dielectric material. For a dielectric cavity, if the material loss is negligible, reducing the cavity size usually causes a significantly increase ...
Lee Yong Seuk - - 2012
Little information exists on the intraoperative difficulties and complications of using a RetroButton (Arthrex, Inc, Naples, Florida), which is a new suspensory device. However, some difficulties are encountered, such as incomplete sitting, pulling at the outside portion of the iliotibial band, or slipping during distal pulling due to incomplete transverse ...
Burcelin Rémy - - 2012
The recent epidemic of obesity and diabetes and the diversity at the individual level could be explained by the intestinal microbiota-to-host relationship. More than four million gene products from the microbiome could interact with the immune system to induce a tissue metabolic infection, which is the molecular origin of the ...
Salvalaggio P R - - 2012
Early allograft dysfunction (EAD) had been related to poor transplant outcomes during the early years of liver transplantation. We sought to determine the incidence of EAD at our unit and to evaluate its impact on posttransplant outcomes. This single-center retrospective study included primary deceased donor liver grafts transplanted under the ...
Bookman Arthur A M - - 2012
In 2009, the Canadian Rheumatology Association (CRA) became the major shareholder of The Journal of Rheumatology Publishing Company Limited, the main holding of which was The Journal of Rheumatology. The CRA made the decision to do this because The Journal was a much-valued publication with an international face, and it ...
Connolly Sean S Department of Physiology, Program in Oncology, Marlene and Stewart Greenbaum Cancer Center, the University of Maryland Baltimore School of Medicine, Baltimore, Maryland 21201, - - 2012
The Ca(2+)/calmodulin-stimulated protein phosphatase calcineurin is a critical component of Ca(2+) signaling cascades in eukaryotic cells. Myristoylation of the regulatory subunit of calcineurin (CNB) is conserved from yeast to humans. Here, we show that CNB myristoylation antagonizes phosphatase activation in yeast. Disruption of CNB myristoylation by mutation of the myristoylated ...
Montgomery Katherine L - - 2012
Research on juvenile offenders has largely treated this population as a homogeneous group. However, recent findings suggest that this at-risk population may be considerably more heterogeneous than previously believed. This study compared mixture regression analyses with standard regression techniques in an effort to explain how known factors such as distress, ...
Matsui Hisanori - - 2012
Metastin/kisspeptin, a hypothalamic peptide, plays a pivotal role in controlling GnRH neurons. Here we studied the effect of chronic sc administration of two kisspeptin analogs, KISS1-305 and TAK-448, on hypothalamic-pituitary-gonadal function in male rats in comparison with a GnRH analogue leuprolide or bilateral orchiectomy (ORX). The prototype polypeptide, KISS1-305 (1-4 ...
Jeelall Yogesh S - - 2012
Self-tolerance and immunity are actively acquired in parallel through a poorly understood ability of antigen receptors to switch between signaling death or proliferation of antigen-binding lymphocytes in different contexts. It is not known whether this tolerance-immunity switch requires global rewiring of the signaling apparatus or if it can arise from ...
Ting Jonathan Y JY Babytalk Research Laboratory, Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA. - - 2012
To examine the hypothesis that infants receiving a degraded auditory signal have more difficulty segmenting words from fluent speech if familiarized with the words presented in both speech and sign compared to familiarization with the words presented in speech only. Experiment utilizing an infant-controlled visual preference procedure. Twenty 8.5-month-old normal-hearing ...
Ma Jian - - 2012
AIMS: Doxorubicin causes damage to the heart, often leading to irreversible cardiomyopathy, which is fatal. Reactive oxygen species (ROS) or oxidative stress is involved in cardiomyocyte death, contributing to doxorubicin-induced cardiotoxicity. This study investigated the role of Rac1, an important subunit of NADPH oxidase in doxorubicin-induced cardiotoxicity and the underlying ...
Cénit Maria Carmen - - 2012
OBJECTIVE: Systemic sclerosis (SSc) is a genetically complex autoimmune disease; the genetic component has not been fully defined. Interleukin 6 (IL-6) plays a crucial role in immunity and fibrosis, both key aspects of SSc. We investigated the influence of IL6 gene in the susceptibility and phenotype expression of SSc. METHODS: ...
Favaro Stefano - - 2012
Species sampling problems have a long history in ecological and biological studies and a number of issues, including the evaluation of species richness, the design of sampling experiments, and the estimation of rare species variety, are to be addressed. Such inferential problems have recently emerged also in genomic applications, however, ...
Béla Samantha R - - 2012
Interleukin-1 receptor (IL1R)-associated kinase 4 (IRAK4) is a member of the IRAK family and has an important role in inducing the production of inflammatory mediators. This kinase is downstream of MyD88, an adaptor protein essential for Toll-like receptor (TLR) function. We investigated the role of this kinase in IRAK4-deficient mice ...
Jia Chenxi C School of Pharmacy and Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53705, - - 2012
A complete understanding of the biological functions of large signaling peptides (>4 kDa) requires comprehensive characterization of their amino acid sequences and post-translational modifications, which presents significant analytical challenges. In the past decade, there has been great success with mass spectrometry-based de novo sequencing of small neuropeptides. However, these approaches ...
Slager Susan L SL Mayo Clinic College of Medicine, Rochester, MN, USA. - - 2012
A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL ...
Garner Bridget C - - 2012
A 5-year-old male neutered reindeer (Rangifer tarandus tarandus) from Missouri was presented with a 3-week history of anorexia, respiratory distress, lethargy, and weight loss. Blood smear review revealed that a small percentage of RBCs contained small (1-2 μm in length) pleomorphic piroplasms (signet ring, rod- or pear-shaped, and elongate forms) with ...
Nguyen H B HB Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, - - 2013
The liver kinase B1 (LKB1) tumor suppressor inhibits cell growth through its regulation of cellular metabolism and apical-basal polarity. The best understood mechanism whereby LKB1 limits cell growth is through activation of the AMP-activated-protein-kinase/mammalian-target-of-rapamycin (AMPK/mTOR) pathway to control metabolism. As LKB1 is also required for polarized epithelial cells to resist ...
Hofmann S - - 2012
Background and objective: Ectodomain shedding is a major mechanism to modulate platelet receptor signaling and to downregulate platelet reactivity. Proteins of the a disintegrin and metalloproteinase (ADAM) family are implicated in the shedding of various platelet receptors. The signaling lymphocyte activation molecule (SLAM) family receptor CD84 is highly expressed in ...
Le Maithao - - 2012
Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide, but only a small percentage of patients are eligible for curative surgical intervention. Over the past decade, radiofrequency ablation (RFA) has been increasingly shown to offer long-term survival benefits. Our study objective was to compare outcomes of patients with ...
Hoeft Fumiko F Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, - - 2012
Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known. To investigate the brain basis of ...
Watson Deborah - - 2012
Although scars are a normal part of the healing process, facial scars have significant implications on a patient's well-being, both physically and psychologically. Facial scars are one of the most common reasons a patient presents to the facial plastic and reconstructive surgeon. The ability to evaluate facial scars and choose ...
Baillargeon Raymond H - - 2012
: There is now emerging epidemiological evidence that a substantial proportion of toddlers in the general population may be experiencing a significant opposition-defiance problem before 2 years of age. This article describes the continuity and discontinuity in boys' and girls' opposition-defiance statuses during toddlerhood. : Data came from The Québec ...
Drilon Alexander A Department of Medicine Thoracic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, - - 2012
Squamous-cell carcinomas of the lung (SQCLCs) are defined by unique clinicopathological and molecular characteristics that have evolved substantially over time. Historically, these neoplasms were the most common subtype of non-small-cell lung cancers and were regarded as central tumours with high molecular complexity without targetable genetic abnormalities. Today, the incidence of ...
Qiu Ciyuan - - 2012
We demonstrate a scalable and reconfigurable optical directed-logic architecture consisting of a regular array of integrated optical switches based on microring resonators. The switches are controlled by electrical input logic signals through embedded p-i-n junctions. The circuit can be reconfigured to perform any combinational logic operation by thermally tuning the ...
Leung Terence S - - 2012
We demonstrate a technique to measure the reflectance of colored objects, including blue, green, and yellow, hidden behind an opaque slab based on acoustically modulated laser speckle. One colored paper at a time was placed behind a 1 cm thick opaque slab with an air gap of 5 mm. Small periodic movements ...
Sriphirom Pornpavit - - 2012
The purpose of this study was to evaluate the effect of a secondary reduction of the femoral component size on flexion and extension gaps intraoperatively in posterior-stabilized total knee arthroplasty (PS-TKA) monitored by computer-assisted surgery. The authors hypothesized that cutting additional bone on the posterior femoral condyle may increase the ...
Requião-Moura L R - - 2012
T-lymphocyte depletion is a strategy to reverse the impact of ischemia-reperfusion injury (IRI) in progression to chronic allograft dysfunction, especially among patients at high risk for delayed graft function (DGF). The present work assessed the effect of thymoglobulin among a population with a high incidence of DGF. We analyzed 209 ...
Furst Daniel E - - 2012
OBJECTIVE: Systemic sclerosis (SSc) is a chronic autoimmune disease. The objective of our study was to estimate the medical costs and healthcare resource use of subjects with SSc in a large US managed care plan. METHODS: Subjects at least 18 years of age and with claims-based evidence of SSc (ICD-9-CM ...
Veverka Vaclav V Department of Biochemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, United - - 2012
A number of secreted cytokines, such as interleukin-6 (IL-6), are attractive targets for the treatment of inflammatory diseases. We have determined the solution structure of mouse IL-6 to assess the functional significance of apparent differences in the receptor interaction sites (IL-6Rα and gp130) suggested by the fairly low degree of ...
Attanasio Giuseppe - - 2012
Abstract Conclusion: The study suggests that Mozart therapy could be a valid alternative to the common sound therapy methods in tinnitus patients. Objectives: The aim of the study was to evaluate the presence of the Mozart effect as indexed by a variation in tinnitus intensity and tolerability. Method: Sixty-two individuals ...
Hanson Kenneth - - 2012
During efforts to stabilize metal oxide bound chromophores for photoelectrochemical applications, a novel, photochemical reaction has been discovered. In the reaction, the bis-phosphonate functional groups C(PO3H2)2(OH) in the metal complex [Ru(bpy)2(4,4'-(C(OH)(PO3H2)2bpy)]2+ are converted into COOH and PO43-. The reaction occurs by sensitized formation of 1O2 by the lowest MLCT excited ...
van Sijl Alper M - - 2012
OBJECTIVE: Rheumatoid arthritis (RA) is associated with an increased cardiovascular (CV) risk, but mechanisms behind this increased risk have not been fully elucidated. Carotid arterial remodeling is the change of structural properties in response to hemodynamic or metabolic factors aimed at keeping wall stress within certain limits. This process might ...
Shin Soon Young - - 2012
Interleukin-11 (IL-11), which belongs to a class of IL6-type cytokines, plays an important role in inflammation, motility, and invasion in cancer. The ras mutation is frequently found in human cancer, but little is known regarding the transcriptional activation of the IL-11 gene by the Ras signal pathway in tumour cells. ...
Allegra Alessandro - - 2012
MicroRNAs (miRNAs) are small non-coding, endogenous, single-stranded RNAs. MiRNAs have been implicated in different areas such as the immune response, neural development, DNA repair, apoptosis, oxidative stress response and cancer. However, while the majority of miRNAs are found intracellularly, a significant number of miRNAs have been observed outside of cells, ...
Chen Desheng - - 2012
Wear debris-induced osteolysis in periprosthetic tissue with aseptic loosening is a serious problem after total joint arthroplasty. Matrix metalloproteinase-9 (MMP-9) is expressed in osteoclast cells that surround loosening peri-implant tissue, but the molecular mechanism of MMP-9 action in wear debris-induced osteolysis remains ambiguous. We used a murine osteolysis model to ...
Li Yongping - - 2012
The dwarf bamboo (Fargesia rufa Yi), growing understory in subalpine dark coniferous forest, is one of the main foods for giant panda, and it influences the regeneration of subalpine coniferous forests in southwestern China. To investigate the effects of elevated CO(2) , temperature and their combination, the dwarf bamboo plantlets ...
Salam Amar M - - 2012
A prospective registry was made of all patients hospitalized with atrial fibrillation (AF) in the State of Qatar from 1991 to 2010. Clinical characteristics, management, and outcomes were compared according to ethnicity (Middle Eastern Arab vs South Asian). During this 20-year period, 2857 Arabs and 548 Asians were hospitalized for ...
Surov Alexey - - 2012
BackgroundTotally implantable venous access devices (TIVAD) may be associated with different complications. Certain mechanical port disorders can easily be diagnosed on chest radiographs if the implanted systems are radiopaque and well visible. There are no reports regarding the visibility of TIVAD on chest X-rays.PurposeTo assess the radio opacity of TIVAD ...
Bacio Guadalupe A GA Department of Psychology, University of California, Los Angeles 90095-1563, USA. - - 2013
Studies indicate that U.S.-born Latino teens exhibit higher rates of alcohol use compared with their foreign-born counterparts. Different hypotheses have been advanced to explain the mechanisms underlying this immigrant paradox, including the erosion of protective cultural factors across generations and increased exposure to risky peer environments in the United States. ...
Li Shisheng - - 2012
Selective removal of metallic single-walled carbon nanotubes (SWCNTs) and consequent enrichment of semiconducting SWCNTs were achieved through an efficient carbothermic reaction with a NiO thin film at a relatively low temperature of 350 °C. All-SWCNT field effect transistors (FETs) were fabricat-ed with the aid of a patterned NiO mask, in ...
Coy P P Department of Physiology, Faculty of Veterinary, University of Murcia, Campus Mare Nostrum, Campus de Espinardo, Murcia 30071, Spain. - - 2012
The oviduct or Fallopian tube is the anatomical region where every new life begins in mammalian species. After a long journey, the spermatozoa meet the oocyte in the specific site of the oviduct named ampulla and fertilization takes place. The successful fertilization depends on several biological processes that occur in ...
Chauhan Ashwini - - 2012
Biofilms that develop on indwelling devices are a major concern in clinical settings. While removal of colonized devices remains the most frequent strategy for avoiding device-related complications, antibiotic lock therapy constitutes an adjunct therapy for catheter-related infection. However, currently used antibiotic lock solutions are not fully effective against biofilms, thus ...
Saidha Shiv - - 2012
OBJECTIVE To determine the relationships between conventional and segmentation-derived optical coherence tomography (OCT) retinal layer thickness measures with intracranial volume (a surrogate of head size) and brain substructure volumes in multiple sclerosis (MS). DESIGN Cross-sectional study. SETTING Johns Hopkins University, Baltimore, Maryland. PARTICIPANTS A total of 84 patients with MS ...
Stenzel Irene - - 2012
Jasmonates are important signals in plant stress responses and plant development. An essential step in the biosynthesis of jasmonic acid (JA) is catalysed by ALLENE OXIDE CYCLASE (AOC) which establishes the naturally occurring enantiomeric structure of jasmonates. In Arabidopsis thaliana, four genes encode four functional AOC polypeptides (AOC1, AOC2, AOC3, ...
Rassart Jessica - - 2012
OBJECTIVE:: Identity formation has been found to relate to psychosocial and disease-specific functioning in chronically ill adolescents. Therefore, examining antecedent factors of identity formation in this population is needed. The main goal of the present longitudinal study was to examine how peer relationship quality influenced identity formation in adolescents with ...
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