Search Results
Results 351 - 400 of 3884
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Ward Roslyn - - 2012
This study evaluates kinematic movements of the jaw and lips in six children (3-11 years) with moderate-to-severe speech impairment associated with cerebral palsy before, during, and after participation in a motor-speech (PROMPT) intervention program. An ABCA single subject research design was implemented. Subsequent to the baseline phase (A), phase B ...
Salm F - - 2012
Chemotherapeutic drug resistance is one of the major causes for treatment failure in high-risk neuroblastoma (NB), the most common extra cranial solid tumor in children. Poor prognosis is typically associated with MYCN amplification. Here, we utilized a loss-of-function kinome-wide RNA interference screen to identify genes that cause cisplatin sensitization. We ...
Poncet Valérie - - 2012
• Premise of the study: Informative markers are required for assessing the diversity of Amborella trichopoda, the only species of its order, endemic to New Caledonia and considered to be the sister species to all flowering plants. Therefore, expressed sequence tag (EST)-based microsatellite markers were developed.• Methods and Results: Fifty-five ...
Mahler Donald A - - 2012
Abstract Background: Patients who exhibit a suboptimal peak inspiratory flow rate (PIFR) against the resistance (resist) of a dry powder inhaler (DPI) may not be able to effectively inhale the medication into their lower respiratory tract. PIFRresist was measured using the In-Check DIAL(®) to simulate the resistance of the Diskus(®) ...
Agyepong Irene Akua - - 2012
Implementation of policies (decisions) in the health sector is sometimes defeated by the system's response to the policy itself. This can lead to counter-intuitive, unanticipated, or more modest effects than expected by those who designed the policy. The health sector fits the characteristics of complex adaptive systems (CAS) and complexity ...
van Maarseveen Erik M - - 2012
Abstract Since the introduction of combination antiretroviral therapy (cART) resulting in the prolonged survival of HIV-infected patients, HIV infection is no longer considered to be a contraindication for solid organ transplantation (SOT). The combined management of antiretroviral and immunosuppressive therapy proved to be extremely challenging, as witnessed by high rates ...
Slack-Smith Linda - - 2012
There is the potential for substantial gains in dental epidemiology with increasing use of population-level data and data linkage. The advantage of population record linkage, from an epidemiological perspective, is that it is not biased and no-one is excluded. This has important implications for human rights because generally the people ...
Li Bo - - 2012
We propose several applications of graded-index (GRIN) time lenses including time-frequency conversion (time-to-frequency conversion and frequency-to-time conversion simultaneously), temporal filtering, and temporal imaging. The evolution of the signal pulses in these systems is demonstrated. As two important parameters, the focal length and the time-frequency conversion factors of time-frequency conversion based ...
Tian Lei - - 2012
We demonstrate a nonlinear diffusion (NLD) regularization method to solve the transport of intensity equation (TIE). A novel NLD regularization function is proposed to enforce piecewise-constant priors and to remove low-frequency artifacts in the TIE solution.
Ahmed Issaq - - 2012
Patients undergoing total knee arthroplasty (TKA) are likely to receive a blood transfusion, which may increase the risk of complications and prolong hospital stay. Considerable variation exists in transfusion practice among orthopedic surgeons following elective TKA. Previous studies have investigated the relationship between preoperative risk factors and the requirement for ...
Salvalaggio P R - - 2012
A new liver allocation system driven by the model for end-stage liver disease (MELD) score was implemented in Brazil in 2006. In association with the new allocation policy, there was a concomitant expansion of the number of donors. We designed this study to assess whether a potential expansion of the ...
Branco K C - - 2012
Organ transplant recipients with refractory rejection or intolerance to the prescribed immunosuppressant may respond to rescue therapy with tacrolimus. We sought to evaluate the clinical outcomes of children undergoing heart transplantation who required conversion from a cyclosporine-based, steroid-free therapy to a tacrolimus-based regimen. We performed a prospective, observational, cohort study ...
Jiang Bo - - 2012
Efficient three-component domino strategies for the synthesis of multifunctionalized tetracyclic indeno[1,2-b]indole derivatives with different substituted patterns have been established successfully. The first pathway involves a novel sequential methyl migration, aromatization, and esterification, while a second reaction in HOAc leads to compounds 6 with high syn diastereoselectivity. Both reactions showed attractive ...
Zhi Xu - - 2012
To identify novel oncogenic E3 ubiquitin ligases as anti-cancer targets, we screened an E3 ubiquitin ligase siRNA library containing siRNA pools against 555 individual E3s using the SRB assay in the MDA-MB-231 breast cancer cell line and the PC3 prostate cancer cell line. RNF126 was identified and validated as a ...
Ronis Martin J J - - 2012
Soy foods have been suggested to have both positive health benefits and potentially adverse effects as a result of their content of phytoestrogens. However, studies on the estrogenicity of soy foods are lacking. Here we directly compared the effects of soy protein isolate (SPI), the protein in soy infant formula, ...
Liu Su - - 2012
Sensory neuron membrane proteins (SNMPs), which are located on the dendritic membrane of olfactory neurons, were considered as important components involved in pheromone reception in insects. In Drosophila melanogaster, mutants without SNMP are unable to evoke neuronal activities in the presence of pheromone cis-vaccenyl acetate (cVA). So deeply understanding the ...
de Rosny Eve - - 2012
KillerRed (KR) is a red fluorescent protein recognized as an efficient genetically encoded photosensitizer. KR generates reactive oxygen species via a complex process of photoreactions, ending up in photobleaching, the mechanism of which remains obscure. In order to clarify these mechanisms, we focus on a single mutant V44A (A44-KR) exhibiting ...
Sluch Ilya M - - 2012
Packing interactions in the crystal structures of a series of cis-M(CNAr)(2)Cl(2) complexes (M = Pt, Pd; Ar = substituted phenyl) were examined and correlated with the luminescence properties of the Pt complexes. The structures of the PhNC and p-tolyl isocyanide complexes exhibit extended chains of metallophilic interactions with M···M distances ...
McGowan Stacey E - - 2012
BACKGROUND: In SPECT images truncation artefacts may occur when the object does not remain in the field of view (FOV). This truncation may lead to distortions in the transmission map (μ map), which would affect the attenuation correction (AC) and possibly the final image. Our aim was to investigate this ...
Schwen Lars Ole - - 2012
Patient-specific analyses of the mechanical properties of bones become increasingly important for the management of patients with osteoporosis. The potential of composite finite elements (CFEs), a novel FE technique, to assess the apparent stiffness of vertebral trabecular bone is investigated in this study. Segmented volumes of cylindrical specimens of trabecular ...
Christie Darah A - - 2012
Stomatin-like protein 2 (SLP-2) is a mostly mitochondrial protein that regulates mitochondrial biogenesis and function and modulates T cell activation. To determine the mechanism of action of SLP-2, we generated T cell-specific SLP-2-deficient mice. These mice had normal numbers of thymocytes and T cells in the periphery. However, conventional SLP-2-deficient ...
Costa M Manuela R - - 2012
Heteroblasty refers to the changes in leaf shape and size (allometry) along stems. Although evolutionary changes involving heteroblasty might contribute to leaf diversity, little is known of the extent to which heteroblasty differs between species or how it might relate to other aspects of allometry or other developmental transitions. Here, ...
Mama Yaniv - - 2012
It takes people longer to name the ink colour of emotion or threat words than that of neutral words, the emotional Stroop effect (ESE). In three experiments with normal and patient populations, we show that the ESE is a special case of a generic attention model and effect entailed in ...
Su Hai-Lun - - 2012
• Premise of the study: Microsatellite markers were developed in Dipteronia sinensis to investigate the population genetics of this endangered plant.• Methods and Results: Using the Fast Isolation by AFLP of Sequences COntaining repeats (FIASCO) protocol, 19 microsatellite loci were developed in D. sinensis and evaluated for their variability in ...
Nahum-Shani Inbal - - 2012
Increasing interest in individualizing and adapting intervention services over time has led to the development of adaptive interventions. Adaptive interventions operationalize the individualization of a sequence of intervention options over time via the use of decision rules that input participant information and output intervention recommendations. We introduce Q-learning, which is ...
Flemming Patricia J - - 2012
Identifying older adults at risk for falls is a challenge all home healthcare agencies (HHAs) face. The process of assessing for falls risk begins with the initial home visit. One HHA affiliated with an academic medical center describes its experience in development and use of a Falls Risk Assessment (FRA) ...
Marsh Louise - - 2012
Objective: To examine trends in young New Zealanders' access to cigarettes from 2002 to 2008. Methods: Self-reports of young smokers' commercial sources of cigarettes, requests for proof of age and being refused a sale, and the amount spent on cigarettes, were analysed from the 2002 and 2004 Youth Lifestyles Surveys ...
Mejia Gloria C - - 2012
This article provides a conceptual base for population oral health measurement and argues that problems associated with particular indices are subject to the basic issues of knowing what to measure and the level of measurement required to address the object of study and provide clear information about the health of ...
Silove Derrick - - 2012
Symptoms of post-traumatic stress disorder (PTSD), anxiety and depression are prevalent among post-conflict populations worldwide but controversy about the cultural meaning of these symptoms, particularly in relation to PTSD, adds to the challenge for psychiatry in mounting appropriate intervention programmes. Accumulating scientific evidence assists in guiding the focus and scope ...
Smith Sunny D - - 2012
Many medical schools have student-run free clinics (SRFCs), yet their educational value has not been well studied. We performed a one-time cross-sectional survey to assess medical student perceptions of the educational value of an SRFC at their institution. The authors designed and validated a survey instrument including six statements on ...
Leosson K - - 2012
Resonant photon tunneling was investigated experimentally in multilayer structures containing a high-contrast (TiO<sub>2</sub>/SiO<sub>2</sub>) Bragg mirror capped with a semitransparent gold film. Transmission via a fundamental cavity resonance was compared with transmission via the Tamm plasmon polariton resonance that appears at the interface between a metal film and a one-dimensional photonic ...
Tantisricharoenkul Gof - - 2012
Tears of the proximal long head of the biceps tendon are among the most common tendon tears in the body. In most cases, the diagnosis is easily determined based on the history and physical examination. However, malignant soft tissue tumors can simulate proximal biceps tendon tears. Although tumors simulating tears ...
Gois P H F - - 2012
Conversion to sirolimus (SRL)-based immunosuppression in renal transplant recipients is an alternative for chronic allograft dysfunction (CAD), cancer and viral infections. We sought to analyze the indications for and safety and efficacy of conversion to SRL among renal transplant patients. We examined a retrospective cohort, using medical records of renal ...
Ajili Faouzia - - 2012
Background: Bacillus Calmette-Guerin (BCG) immunotherapy is regarded as the current treatment of choice for non muscle invasive bladder cancer (NMIBC), though its efficacy is limited by high recurrence and progression rate. Identification of factor prognosticators that might be helpful in discriminating between responders and nonresponders to BCG treatment is therefore ...
Faget Julien - - 2012
Human breast tumors are infiltrated by memory CD4+ T cells along with increased numbers of regulatory T cells (Treg) and plasmacytoid dendritic cells (pDC) that facilitate immune escape and correlate with poor prognosis. Here we report that ICOS, a T cell co-stimulatory molecule of the CTLA4/PD1/CD28 family, is expressed mostly ...
Price Megan - - 2012
BACKGROUND: Recent research has proposed a new method for defining a favorable outcome in traumatic brain injury and stroke research. PURPOSE: This new method is called the sliding dichotomy, and it is suggested as a potential solution to the problem of underpowered clinical trials. METHODS: We present a brief simulation ...
Bohn Annette - - 2012
When do children develop the ability to imagine their future lives in terms of a coherent prospective life story? We investigated whether this ability develops in parallel with the ability to construct a life story for the past and narratives about single autobiographical events in the past and future. Four ...
Breining Scott R - - 2012
The potential for nicotinic ligands with affinity for the α4β2 or α7 subtypes to treat such diverse diseases as nicotine addiction, neuropathic pain, neurodegenerative and cognitive disorders has been exhibited clinically for several compounds while preclinical activity in relevant in vivo models has been demonstrated for many more. For several ...
Graham Keith - - 2012
For prostate cancer, Prostate Specific Membrane Antigen (PSMA) has been identified as a diagnostic and therapeutic target. Fluorinated derivatives of 2-(phosphonomethyl)pentanedioic acid were designed and synthesized to explore whether this fluorine-substituent is tolerated in the pentanedioic acid moiety which is common to almost all PSMA targeting small molecule inhibitors. The ...
- - 2012
These guidelines are intended to assist psychologists, other health care providers, administrators in health care delivery systems, and the public to conceptualize the roles and responsibilities of psychologists in these diverse contexts. These guidelines are informed by the Ethical Principles of Psychologists and Code of Conduct ("APA Ethics Code"; APA, ...
Kim Gahee - - 2012
New zwitterionic polymer-coated immunoaffinity beads were developed to resist nonspecific protein adsorption from undiluted human serum for diagnostic applications of exosomes. A zwitterionic sulfobetaine monomer with an amine functional group was employed for a simple surface chemistry and antifouling properties. An exosomal biomarker protein, epithelial cell adhesion molecule (EpCAM) was ...
Maglio Sam J - - 2012
What is the difference between far and further? Investigations into such psychological distancing-removal from an egocentric reference point-have suggested similarities between geographical space, time, probability, and social distance. We draw on these similarities to propose that experiencing any kind of distance will reduce sensitivity to any other distance. Nine studies ...
Yoshida Satoko - - 2012
Arbuscular mycorrhiza (AM) represents an ancient endosymbiosis between plant roots and Glomeromycota fungi. Strigolactones (SLs), plant-derived terpenoid lactones, activate hyphal branching of AM fungi before physical contact. Lack of SL biosynthesis results in lower colonization of AM fungi. The F-box protein, DWARF3 (D3), and the hydrolase family protein DWARF14 (D14) ...
Saha Animesh - - 2012
Poly(ß-hydroxyl amine)s are prepared from readily available small molecular building blocks at ambient conditions. These macromolecules can be transformed into main-chain cationic polymers upon quaternization of the backbone amine units. The modular and mild nature of the synthesis allows for incorporation of multiple (2-4) chemically distinct reactive sites in the ...
Benharash Peyman - - 2012
Understanding cardiovascular physiology, pharmacology, and treatment of shock is heavily emphasized in current medical school and surgical training. Performance of individuals in treatment of critical illness remains poor despite regular didactic sessions. We have developed a PC computer-based simulator capable of integrating basic hemodynamic parameters to dynamically generate a realistic ...
Steele Jimmy - - 2012
To take an overview of the history and future of oral health surveillance. A brief review of the history and policy context of national surveys and equivalent large surveys of oral health and their objectives followed by an analysis of their fitness for modern purpose. The quality of oral health ...
Flora Parminder K - - 2012
Research on exercise identity (EXID) indicates that it is related to negative affect when exercisers are inconsistent or relapse. Although identity theory suggests that causal attributions about this inconsistency elicit negative self-conscious emotions of shame and guilt, no EXID studies have examined this for exercise relapse. Weiner's attribution-based theory of ...
Lin Hsing-Ying - - 2012
A proof-of-concept multiwindow fiber-optic sensor utilizing multiple particle plasmon resonance (PPR) of silver nanoparticles and gold nanorods separately on two unclad portions of the fiber for multianalyte detection is demonstrated. The detection is based on intensity interrogation of multiple wavelengths by a single detector. Time division multiplexing is employed to ...
Pham Quang Duc - - 2012
We propose a new method for three-dimensional (3D) position measurement of nanoparticles using an in-line digital holographic microscope. The method improves the signal-to-noise ratio of the amplitude of the interference fringes to achieve higher accuracy in the position measurement by increasing weak scattered light from a nanoparticle relative to the ...
Mauffrey Cyril - - 2012
Despite the frequency of open fractures, their management remains one of the greatest and most debated orthopedic challenges. The current challenges that health care faces financially and clinically offer an opportunity to develop a universal reliable, reproducible, evidence-based protocol. The authors review the current evidence concerning the acute management of ...
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