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Chen Tianyou - - 2012
Organic-inorganic hybrid mesoporous polymers were successfully synthesized by using a template-directed free radical polymerization technique in aqueous solution at 0-5 oC with oxidative complexes as self-decomposed soft templates. The oxidative complexes ((CTA)2S2O8), which were formed between anionic oxidant (S2O82-) and cationic surfactant (cetyl trimethylammonium bromide, CTAB) at 0-5 oC, can ...
Franklin Robin J M - - 2012
Multiple sclerosis (MS) is an inflammatory demyelinating disease that is considered by many people to have an autoimmune aetiology. In recent years, new data emerging from histopathology, imaging and other studies have expanded our understanding of the disease and may change the way in which it is treated. Conceptual shifts ...
Zhao Jiaji - - 2012
An efficient synthesis of 2- or 4-iododibenzofurans through CuI-mediated sequential iodination/cycloetherification of two aromatic C-H bonds in o-arylphenols has been developed. Both the preexisting electron-withdrawing groups (NO(2), CN, and CHO) and the newly introduced iodide are readily modified for a focused dibenzofuran library synthesis. Mechanistic studies and DFT calculations suggest ...
Shi Yizhi - - 2012
Amplitude modulation (AM) scanning force microscopy (SFM) is superior to frequency modulation SFM in simplicity, sensitivity, and stability, but is still replaced by the latter because it is too slow when the Q factor is high (bandwidth < 0.5 Hz for Q > 50,000 and resonant frequency ω0 < 50 ...
Cao Zhen-Hui - - 2012
Pu-erh tea has shown anti-obesity effects but little is known about its effect on proliferation and differentiation of preadipocytes. This study investigated the effects of the aqueous extracts of raw pu-erh tea and ripened pu-erh tea on proliferation and differentiation of murine 3T3-L1 preadiopocytes. We examined dose and time effects ...
Pan Zhi-Zhen - - 2012
4'-Thiosemicarbazonegriseofulvin, a new thiosemicarbazide derivative of griseofulvin, was synthesized and evaluated for its potential on the control of enzymatic browning and postharvest disease of fruits. Browning on fruits is mainly due to the enzymatic oxidation of phenolic compounds catalyzed by tyrosinase. 4'-thiosemicarbazonegriseofulvin could effectively inhibit the activity of tyrosinase and ...
Martínez-Aguilar Juan - - 2012
This review documents the uses of quantitative mass spectrometry applied to colorectal cancer (CRC) proteomics for biomarker discovery and molecular pathway profiling. Investigators are adopting various labeling and label-free mass spectrometry approaches to quantitate differential protein levels in cells, tumours and plasma/serum. We comprehensively review recent uses of this technology ...
Boschetti Elisa - - 2012
In this study, we sought the use of cultured human abdominal aortic aneurysm (AAA) tissue to investigate the transcriptional effects of some bioactives, whose role in the prevention of atherosclerotic plaque development through the regulation of gene expression has been hypothesized. After supplementation with n - 3 polyunsaturated fatty acids or epigallocatechin-3-gallate, ...
Karimi Mohsen - - 2012
We report a case of tricuspid atresia with transposed great arteries and rudimentary right ventricle owing to which the patient developed severe subaortic stenosis and restrictive bulboventricular foramen 5 years after her extracardiac Fontan operation. She underwent a successful modified Damus-Kaye-Stansel operation using her native pulmonary valve. Spiral cardiac computed ...
Valdivieso Rommel - - 2012
  A teenager with atopic dermatitis presented with a 12-month history of recurrent, pruritic, round and polygonal patches on her face. Patch tests using the European standard series (including nickel, chromium, and cobalt chloride), a plastic and glue series of allergens, polyester components, and personal and environmental products in contact ...
Katsoulis Joannis - - 2012
OBJECTIVE: To analyze the precision of fit of implant-supported screw-retained computer-aided-designed and computer-aided-manufactured (CAD/CAM) zirconium dioxide (ZrO) frameworks. MATERIALS AND METHODS: Computer-aided-designed and computer-aided-manufactured ZrO frameworks (NobelProcera(™) ) for a screw-retained 10-unit implant-supported reconstruction on six implants (FDI positions 15, 13, 11, 21, 23, 25) were fabricated using a laser ...
Barbosa Luiz Claudio Almeida - - 2012
Many natural products have been used as a model for the development of new drugs and agrochemicals. Following this strategy eleven rubrolide analogues, bearing electron withdrawing and donating groups at both benzene rings, were prepared starting from commercially available mucobromic acid. The ability of all compounds to inhibit the photosynthetic ...
Avalos Elisea E - - 2012
OBJECTIVE: Studies examining the association of dairy consumption with incident CHD have yielded inconsistent results. The current prospective study examined the association between dairy consumption and CHD in a population-based sample of older community-dwelling adults. DESIGN: Baseline CHD risk factors were assessed and an FFQ was self-administered. Participants were followed ...
Diaper Alison - - 2012
Symptoms of anxiety induced by 7.5% CO(2) inhalation can be attenuated by acute administration of GABA(A) receptor anxiolytics such as lorazepam and alprazolam. This study investigated if these effects are dose-related, by comparing a 0.5 mg dose (considered non-clinically effective) and a 2 mg dose of lorazepam (clinically effective) on ...
Turris Sheila A - - 2012
Triage is a complex process and is one means for determining which patients most need access to limited resources. Triage has been studied extensively, particularly in relation to triage in overcrowded emergency departments, where individuals presenting for treatment often are competing for the available stretchers. Research also has been done ...
Mosca Andrea - - 2012
Abstract Background: We present a study aimed to define the analytical goals for the determination of hemoglobin A2, a minor hemoglobin present in human blood normally accounting from 2.5% to 3.3% of total hemoglobin, and typically increased up to 6%-7% in subjects carriers of β-thalassemia. Methods: The analytical goals have ...
Kim Bo-Hyung - - 2012
BACKGROUND: Clopidogrel selectively inhibits platelet aggregation. Clopidogrel bisulfate (Plavix(®)) was first developed for atherothrombosis prevention and is commonly prescribed for this indication. A new clopidogrel formulation, clopidogrel besylate (KOVIX(®)), has recently been developed. OBJECTIVE: This study was designed to compare the multiple-dose pharmacokinetics/pharmacodynamics and tolerability of clopidogrel besylate with those ...
Aggarwal Rakesh - - 2012
Hepatitis E, caused by infection with hepatitis E virus (HEV), is a common cause of enterically-transmitted acute hepatitis in developing countries. Occasional cases of sporadic hepatitis E have been increasingly recognized in developed countries over the past decade. These cases differ from those in developing countries in being possibly caused ...
Oveland Eystein - - 2012
The spleen is a part of the immune system and is involved in the response to a systemic inflammation induced by blood borne pathogens that may induce sepsis. Knowledge about the protein composition of the spleen microenvironment in a control situation and during systemic inflammation may contribute to our understanding ...
Keeney Jeriel T R - - 2012
Proteomics has a wide range of applications, including determination of differences in the proteome in terms of expression and post-translational protein modifications. Redox proteomics allows the identification of specific targets of protein oxidation in a biological sample. Using proteomic techniques, apolipoprotein A-I (ApoA-I) has been found at decreased levels in ...
Jo Mi Ru - - 2012
We report on the synthesis of one-dimensional (1D) Li(4)Ti(5)O(12) nanofibers through electrospinning and their outstanding electrochemical performances. Li(4)Ti(5)O(12) with a spinel structure is a promising candidate anode material for lithium rechargeable batteries due to its well-known zero-strain merits. In order to improve the electronic properties of spinel Li(4)Ti(5)O(12), which are ...
Papi M - - 2012
Aspergillus fumigatus has become a leading cause of fungal morbidity and mortality, especially in immunocompromised patients. This fungus is able to grow as a multicellular community and produce a hydrophobic extracellular matrix (ECM), mainly composed of galactomannan and α-1,3 glucans, to protect itself from host defenses and antimicrobial drugs. This ...
Ureña Esteban Bermúdez - - 2012
Plasmonic antennas are key elements to control the luminescence of quantum emitters. However, the antenna's influence is often hidden by quenching losses. Here, the luminescence of a quantum dot coupled to a gold dimer antenna is investigated. Detailed analysis of the multiply excited states quantifies the antenna's influence on the ...
von Geldern Gloria - - 2012
The effect of nutrition and dietary supplements on the course of multiple sclerosis (MS) is a topic of great interest to both patients and clinicians. In particular, vitamin D status has been shown to influence both the incidence and the course of MS. High vitamin D levels are probably protective ...
Weitz Nicole A - - 2012
We present a case of a large congenital hemangioma (CH) on the neck causing cardiac failure and thrombocytopenia in a female neonate. A trial of medical therapy with corticosteroids and propranolol was attempted, but the patient ultimately underwent definitive treatment with embolization and surgical resection with a positive outcome. A ...
Lindqvist Gunilla - - 2012
Aim To describe conceptions of daily life in men living with a woman suffering from chronic obstructive pulmonary disease (COPD) in different stages of the disease. BACKGROUND: A chronic disease like COPD affects not only the person living with the illness, but also the spouse. Significant tasks and demands are ...
Leão C A - - 2012
Malakoplakia is a rare chronic granulomatous disease of unknown cause. It is thought to be caused by an acquired bactericidal defect of macrophages. Malakoplakia is associated with chronic infections and immunosuppression. Although it occurs mainly in the urinary tract, it has already been reported in almost every organ system. The ...
Goldmann Tobias - - 2012
Translational read-through-inducing drugs (TRIDs) promote read-through of nonsense mutations, placing them in the spotlight of current gene-based therapeutic research. Here, we compare for the first time the relative efficacies of new-generation aminoglycosides NB30, NB54 and the chemical compound PTC124 on retinal toxicity and read-through efficacy of a nonsense mutation in ...
Reed Mary - - 2012
Physicians can receive federal payments for meaningful use of complete certified electronic health records (EHRs). Evidence is limited on how EHR use affects clinical care and outcomes. To examine the association between use of a commercially available certified EHR and clinical care processes and disease control in patients with diabetes. ...
Zuber Julien J Service de Transplantation Rénale Adulte, Hôpital Necker, 161 rue de Sèvres, 75015 Paris, - - 2012
In the past decade, a large body of evidence has accumulated in support of the critical role of dysregulation of the alternative complement pathway in atypical haemolytic uraemic syndrome (aHUS) and C3 glomerulopathies. These findings have paved the way for innovative therapeutic strategies based on complement blockade, and eculizumab, a ...
Stegall Mark D MD Department of Surgery, Division of Transplantation Surgery and von Liebig Transplant Center, 200 First Street SW, Mayo Clinic, Rochester, MN 55905, USA. - - 2012
Over the past decade, several studies have suggested that the complement system has an active role in both acute and chronic allograft rejection. These studies have been facilitated by improved techniques to detect antibody-mediated organ rejection, including immunohistological staining for C4d deposition in the allograft and solid-phase assays that identify ...
Momper J D JD Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, - - 2013
BK virus (BKV) infection in kidney transplant recipients is associated with progressive graft dysfunction and graft loss. Cidofovir, an antiviral agent with known nephrotoxicity, has been used in low doses to treat BKV infections. However, the systemic exposure and disposition of the low-dose cidofovir regimen are not known in kidney ...
Bernosky-Smith Kimberly A KA Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina, - - 2012
The rate of alcohol drinking has been shown to predict impairment on cognitive and behavioral tasks. The current study assessed the influence of speed of alcohol consumption within a laboratory-administered binge on self-reported attitudes toward driving and simulated driving ability. Forty moderate drinkers (20 female, 20 male) were recruited from ...
Barbosa-Leiker Celestina C College of Nursing, Washington State University, PO Box 1495, Spokane, WA 99210-1495, USA. - - 2013
Measurement invariance of the 2-factor model of the Perceived Stress Scale--10-item version (Cohen & Williamson, 1988) was tested across men and women at two time points and in the combined total sample over a 2-year time frame (n = 871). Measurement invariance results indicated that the scale measured the latent factors, stress ...
Larif Sofiene S a Faculty of Medicine of Sousse, Metabolic Biophysics and Applied Pharmacology Laboratory, Department of Biophysics , Avenue Mohamed Karoui , Sousse , 4002 , - - 2013
Thiopurine S-methyltransferase (TPMT) is an important enzyme that metabolizes thiopurine drugs. This enzyme exhibits a large number of interindividual polymorphism. TPMT(∗)23 polymorphism has been reported in a few cases in the world in co-dominance with TPMT(∗)3A. The phenotype has been reported to affect enzyme activity in vivo and in vitro. ...
Marasca Roberto R Division of Hematology, Dipartimento di Scienze Mediche e Chirurgiche Materno-infantili e dell'Adulto, University of Modena and Reggio Emilia, Modena, Italy. - - 2013
Deletion on the long arm of chromosome 11 occurs in 5-20% of chronic lymphocytic leukaemia (CLL) patients. We analysed clinical-biological characteristics of 131 CLL patients carrying 11q deletion documented before therapy (de novo 11q deleted CLL). De novo 11q deleted CLL were characterized by high frequencies of unmutated immunoglobulin variable ...
Falorio Simona S Dipartimento di Ematologia, Ospedale Civile Spirito Santo, Pescara, - - 2013
Hodgkin lymphoma (HL) is one of the most common types of cancer in the young and one of the most curable forms of cancer. Therefore, there has been an increasing interest in the study of long-term morbidities. The aims of the present study were to evaluate the prevalence and risk ...
Delbanco Tom T Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, - - 2012
Little information exists about what primary care physicians (PCPs) and patients experience if patients are invited to read their doctors' office notes. To evaluate the effect on doctors and patients of facilitating patient access to visit notes over secure Internet portals. Quasi-experimental trial of PCPs and patient volunteers in a ...
Goodwin Donna L - - 2012
There has been little critical exploration of the ethical issues that arise in professional practice common to adapted physical activity. We cannot avoid moral issues as we inevitably will act in ways that will negatively affect the well-being of others. We will make choices, which in our efforts to support ...
Chaudhry Kashif N - - 2012
Data from randomized controlled trials suggest that treating hypertension in the elderly, including octogenarians, may substantially reduce the risk of cardiovascular disease and death. However, treatment remains challenging because of comorbidities and aging-related changes. We present common case scenarios encountered while managing elderly patients with hypertension, including secondary hypertension, adverse ...
Van Hove Geert - - 2012
Abstract In this article, the authors relate the life of Chris through narrative snapshots. Chris asked the authors to tell her story. They decided that it could be used to provide an insight into the different ways people with labels are confronted with professional practices and rituals. Although Chris lived ...
Qureshi Moqueet A - - 2012
This study determined the effect of pulmonary disease on outcomes after endovascular abdominal (EVAR) and endovascular thoracoabdominal aortic aneurysm (eTAAA) repair. A prospective study of high-risk patients undergoing EVAR and eTAAA repair between 1998 and 2009 was used to contrast clinical and endovascular outcomes between patients with (group 1) and ...
Bohensky Megan A - - 2012
To assess the use of elective knee arthroscopy procedures for all adults 20 years and older, and for adults with a concomitant diagnosis of osteoarthritis (OA) in Victoria. Retrospective, longitudinal cohort study of 807 030 elective orthopaedic admissions using routinely collected public and private hospital data from 1 July 2000 ...
Sorvajärvi Tapio - - 2012
A sensitive and selective optical technique to detect potassium chloride (KCl) vapor is introduced. The technique is based on the photofragmentation of KCl molecules, using a pulsed UV laser, and optical probing of the temporarily increased amount of potassium atoms with a near-infrared laser. The two laser beams are aligned ...
Kim Kyoohyun - - 2012
A simple and practical method for measuring the angle-resolved light scattering (ARLS) from individual objects is reported. Employing the principle of inline holography and a Fourier transform light scattering technique, both the static and dynamic scattering patterns from individual micrometer-sized objects can be effectively and quantitatively obtained. First, the light ...
Sadhu Anita - - 2012
The purpose of this anatomic study was to determine the extent of lateral dissection that can be performed during anterior cervical decompression and fusion to maximize decompression without compromising the vertebral arteries. Although vertebral artery injury is rare, it is sometimes catastrophic and leads to significant morbidity and mortality. Previous ...
Lima M L - - 2012
There is a growing need to improve heart preservation benefit the performance of cardiac operations, decrease morbidity, and more important, increase the donor pool. Therefore, the objective of this study was to evaluate the cardioprotective effects of Krebs-Henseleit buffer (KHB), Bretschneider-HTK (HTK), St. Thomas No. 1 (STH-1), and Celsior (CEL) ...
Elgazwy Abdel-Sattar S Hamad - - 2012
Khelline is naturally occurring furochromone exhibited significant Epidermal Growth Factor Receptor (EGFR) inhibitory activity. The newly synthesized compounds 2-5 displayed the most potent EGFR inhibitory activity on MCF-7 and HeLa. In vitro study against 59 different human tumour cell lines derived from nine cancer type in NCI (USA), which was ...
Ghosh Deepa - - 2012
BACKGROUND: Small vitiliginous patches have been treated with epidermal grafts or their cell suspensions. In an attempt to overcome some of the shortcomings of cell suspension delivery, we have delivered melanocytes on a polymeric film. OBJECTIVES: To evaluate the clinical effectiveness of a cultured graft consisting of autologous cultured melanocytes ...
Bayindir Funda - - 2012
Introduction:  Understanding the distribution of incisal translucency will provide clinicians a guide to use this knowledge to improve the esthetic replication of anterior restorations. The aim of this study is to investigate the distribution of incisal translucency of unrestored vital natural maxillary central, lateral, and canine vital teeth from a ...
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