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Zheng Y Y Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, IL 60607, - - 2013
Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase expressed in epithelial cancers. Disruption of Ptk6 decreases azoxymethane-induced colon tumorigenesis in mice by preventing signal transducer and activator of transcription 3 activation. Relocalization of PTK6 in prostate cancers contributes to increased growth. Although not expressed in normal breast or ...
Vos Hedwig M M - - 2012
BACKGROUND: In planning a prevention programme, it is important to know to what extent gender, risk behaviour and GP consultation need to be taken into account. OBJECTIVE: To determine whether gender plays a role in the relation between risk behaviour and use of GP services. METHODS: The data used in ...
Tagaya Mitsuhiko - - 2012
Abstract Conclusion: Persistent obstructive sleep apnoea syndrome (OSAS) occurs in approximately 20% of normal-weight children after adenotonsillectomy (T&A) and, in nearly 70% of them, it is caused by adenoid regrowth. Patients with severe or moderate OSAS showed a high incidence of persistent disease even after T&A. Allergic disease, severity and ...
Biniek Krysta - - 2012
The ubiquitous presence of solar UV radiation in human life is essential for vitamin D production but also leads to skin photoaging, damage, and malignancies. Photoaging and skin cancer have been extensively studied, but the effects of UV on the critical mechanical barrier function of the outermost layer of the ...
Dönhöfer Alexandra - - 2012
Ribosome protection proteins (RPPs) confer tetracycline resistance by binding to the ribosome and chasing the drug from its binding site. The current model for the mechanism of action of RPPs proposes that drug release is indirect and achieved via conformational changes within the drug-binding site induced upon binding of the ...
Quint Karl - - 2012
Objective response rates to standard chemotherapeutic regimens remain low in pancreatic cancer. Subpopulations of cells have been identified in various solid tumors which express stem cell-associated markers and are associated with increased resistance against radiochemotherapy. We investigated the expression of stem cell genes and markers of epithelial-mesenchymal transition in pancreatic ...
Giuffrè Mario - - 2012
Aim of the study: Newborns from multiple pregnancies are increasing in number and demonstrate a higher perinatal morbidity and mortality compared to singletons. Prematurity is the main reason for most neonatal diseases in twins, but other variables may play a role and their prenatal evaluation may improve the overall outcome. ...
Manunga Jesse - - 2012
Methicillin-resistant Staphylococcus aureus (MRSA) is an increasingly common cause of postoperative surgical site infections (SSIs). It is unclear, however, whether asymptomatic colonization or nosocomial acquisition of MRSA results in postoperative SSI. We conducted a retrospective review of patients screened for MRSA between May 2008 and October 2010 at our institution. ...
Byers Amy L - - 2012
Despite the frequent occurrence of depressive symptoms among older adults, especially women, little is known about the long-term course of late-life depressive symptoms. To characterize the natural course of depressive symptoms among older women (from the young old to the oldest old) followed up for almost 20 years. Using latent-class ...
Barrow P A - - 2012
As a part of the 40th anniversary celebrations of Avian Pathology we review the last four decades of Salmonella research which has led to major progress in our understanding of the bacteriology and infection biology of the organism through the huge advances in molecular biology and immunology that have accompanied ...
Liotta Dara R - - 2012
Large scars in the head and neck are often the cause of significant emotional distress to patients, and often present unique challenges to the plastic and reconstructive surgeon undertaking their revision. The primary goal of scar revision is to eliminate compromise of function that may have resulted from scar contracture; ...
Newton Jonathon Timothy - - 2012
Promoting the health of populations demands the adoption of a perspective exploring the societal, political, community, family and individual determinants of health. I will argue that to develop interventions to modify health-related behaviours and health risks requires collaboration with a range of disciplines, in order to draw upon their theoretical, ...
Soden Sarah E - - 2012
: Fractures and pain, secondary to low bone mineral density (BMD), have been reported in pediatric patients with autistic spectrum disorders (ASD). The purpose of this study was to assess the BMD of a clinical sample of 10- to 18-year olds with ASD, and the nutrition and physical activity correlates ...
Schneider Bryan P BP Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA. - - 2012
Antiangiogenic treatments have shown activity across multiple tumour types and in various settings. Despite having been approved on the basis of efficacy, the therapeutic index varies substantially in different settings for many of these agents. A major limitation is the current inability to personalise treatment a priori according to findings ...
Shen Huanhuan - - 2012
We propose an original cylindrical interferometric out-of-focus imaging setup to realize the characterization of spherical droplets in a volume. The longitudinal position of the droplets is determined through the orientation of the fringes while the diameter of the droplets is obtained from the frequency of the fringes. The experiments agree ...
Sun Jinghua - - 2012
A new antireflective silica film with closed mesopores was successfully prepared for the optical elements used in vacuum of a high-power laser system. The ordered cagelike mesopores were formed with the direction of surfactant F127 and then closed by long-chain fluoroalkylsilane. The grazing incident x-ray diffraction and grazing incident small-angle ...
Yim Ji Hyeon - - 2012
Although opening-wedge high tibial osteotomy (HTO) is used to correct deformities, it can simultaneously alter tibial slope in the sagittal plane because of the triangular configuration of the proximal tibia, and this undesired change in tibial slope can influence knee kinematics, stability, and joint contact pressure. Therefore, medial opening-wedge HTO ...
Reigada C H P - - 2012
Sirolimus has immunosuppressive properties and antitumor effects. It was prescribed in liver transplantation initially in association with calcineurin inhibitors because of its lower nephrotoxic and neurotoxic effects and its potential antitumor effects. The aim of this study was to analyze the use of sirolimus as rescue therapy for liver transplant ...
Beckers Henny J M - - 2012
Purpose:  To study the effect of patient education and the TravAlert(®) -Eyot(®) drop guider on intraocular pressure (IOP) and adherence in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT) monitored with the TravAlert(®) dosing aid. Methods:  Multicentre, randomized, controlled clinical trial among 18 Dutch hospitals. Patients were ...
Wu Yuan Y Department of Basic Medical Sciences, Medical College, Zhongshan Hospital, Xiamen University, 361005 Fujian, - - 2012
MEN1, which encodes the nuclear protein menin, acts as a tumor suppressor in lung cancer and is often inactivated in human primary lung adenocarcinoma. Here, we show that the inactivation of MEN1 is associated with increased DNA methylation at the MEN1 promoter by K-Ras. On one hand, the activated K-Ras ...
Benito Javier - - 2012
This study evaluated the types of items owners consider important to their cats' quality of life (QoL). We hypothesized that items contributing to QoL in cats are predominantly items requiring mobility. The objectives of the study were to describe the types of items considered important by owners for their cats' ...
Tesla Rachel R Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, - - 2012
We previously reported the discovery of P7C3, an aminopropyl carbazole having proneurogenic and neuroprotective properties in newborn neural precursor cells of the hippocampal dentate gyrus. We have further found that chemicals having efficacy in this in vivo screening assay also protect dopaminergic neurons of the substantia nigra following exposure to ...
Alonso-Sáez Laura - - 2012
Despite the high abundance of Archaea in the global ocean, their metabolism and biogeochemical roles remain largely unresolved. We investigated the population dynamics and metabolic activity of Thaumarchaeota in polar environments, where these microorganisms are particularly abundant and exhibit seasonal growth. Thaumarchaeota were more abundant in deep Arctic and Antarctic ...
Rich Peter - - 2012
A stand-alone online teaching module was developed to cover an area of musculoskeletal anatomy (structure of bone) found to be difficult by students. The material presented in the module was not formally presented in any other way, thus providing additional time for other curriculum components, but it was assessed in ...
Baglioni Michele - - 2012
Nanostructured soft matter systems represent effective and long-lasting solutions with respect to traditional and often obsolete methodologies for the conservation of works of art. In particular, complex fluids such as micelles and microemulsions represent the most performing media for the removal of organic materials from porous supports, like wall paintings ...
Merki R - - 2012
Over the recent years we have seen a rapid increase in published research both in the preclinical and clinical field regarding the treatment of prostate cancer. Only within the last two years the results of four positive phase III trials, all showing improved survival for patients with metastatic castration resistant ...
Hajaj Barak - - 2012
Streptococcus pneumoniae is an aerotolerant gram-positive bacterium that causes an array of diseases, including pneumonia, otitis media, and meningitis. During aerobic growth, S. pneumoniae produces high levels of H(2)O(2). Since S. pneumoniae lacks catalase, the question of how it controls H(2)O(2) levels is of critical importance. The psa locus encodes ...
Choe Chi-un - - 2013
Phosphorylated creatine (Cr) serves as an energy buffer for ATP replenishment in organs with highly fluctuating energy demand. The central role of Cr in the brain and muscle is emphasized by severe neurometabolic disorders caused by Cr deficiency. Common symptoms of inborn errors of creatine synthesis or distribution include mental ...
Yang Yinliang Y Lehrstuhl für Chemie der Biopolymere, Technische Universität München, Weihenstephaner Berg 3, 85354 Freising, - - 2013
The study of metabolically labeled or probe-modified proteins is an important area in chemical proteomics. Isolation and purification of the protein targets is a necessary step before MS identification. The biotin-streptavidin system is widely used in this process, but the harsh denaturing conditions also release natively biotinylated proteins and non-selectively ...
Vernitsky Helly - - 2012
Lymphocytes establish dynamic cell-cell interactions with the cells they scan. Previous studies show that upon cell contact, various membrane-associated proteins, such as Ras-family proteins, transfer from B to T and NK lymphocytes. Mutations in RAS genes that encode constitutively active, GTP-bound, oncoproteins are rather common in human cancers; for instance, ...
van Hoof Bram - - 2012
Spontaneous aggregation of lipids into bilayers and vesicles is a key property for the formation of biological membranes. Understanding the compartmentalization achieved by vesicle formation is an important step towards understanding the origin of life, and is crucial in current efforts to develop artificial life. Spontaneously formed vesicles may be ...
Ahmed H A - - 2012
The epidemiology of foot-and-mouth disease (FMD) in North Africa is complicated by the co-circulation of endemic FMD viruses (FMDV), as well as sporadic incursions of exotic viral strains from the Middle East and Sub-Saharan Africa. This report describes the molecular characterization of SAT 2 FMD viruses that have caused widespread ...
Gall Seana - - 2012
Objective : To describe serum folate status and the socio-demographic correlates of serum folate status in a national sample of women aged 26-36 years in Australia, 2004-2006. Methods: Stored serum samples from 1,046 women, collected as part of the Childhood Determinants of Adult Health study, were analysed for serum folate. ...
van Os Jim - - 2012
Stress-induced alterations in how a person attributes meaning to internal and external stimuli may represent the first step in explaining how population ethnic minority-majority interactions affect mental health. Cross-context and diagnostic assumption-free research is required to elucidate how the wider social environment interacts with personal characteristics to increase expression of ...
Keehbauch Jennifer - - 2012
The study objective was to determine the influence of the 2001 and 2006 American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines changes on colposcopy training at one family medicine residency. We conducted a retrospective chart review from January 1, 2000 to October 31, 2009. The 2001 ASCCP guidelines were ...
Bismuth Jean - - 2012
General surgery residents graduate with an inconsistent knowledge of cardiovascular disease and an inadequate skill set for the practice of vascular surgery. Vascular educators have proposed to overcome these challenges by incorporating standardized milestones and simulation curricula into vascular education, but at present, nonclinical vascular education remains nonstandardized. The first ...
Loeser Markus - - 2012
Fabrication, spectroscopic properties, and laser performance of a Yb:SiO<sub>2</sub> multicomponent glass have been investigated in this paper. The glass system composed of SiO<sub>2</sub>, Al<sub>2</sub>O<sub>3</sub>, and La<sub>2</sub>O<sub>3</sub> excels in terms of a high thermal stress resistance compared to other laser glasses. The laser experiments were conducted with a 3.4 mm thick and ...
Kevin Ko Jia-Wei - - 2012
The median nerve provides sensory innervation to the radial aspect of the hand, including the palm, thumb, index, long, and half of the ring fingers. It provides motor innervation to most of the volar forearm musculature and, importantly, to m ost of thenar musculature. The main goal of median nerve ...
Buluc Levent - - 2012
Acromicric dysplasia is a skeletal dysplasia that is characterized by short stature, short hands and feet, typical facial dysmorphism, normal mental development, and characteristic hand radiology. Carpal tunnel syndrome may be seen in adults with acromicric dysplasia; however, to the authors' knowledge, it has not been reported in pediatric patients. ...
Malheiro J - - 2012
Accurate monitoring of estimated glomerular filtration rate (GFR) is essential for an optimal management of kidney transplant (KT) patients. We aimed to compare the predictive performance of creatinine- and cystatin C-based GFR with creatinine clearance (CCr) in a 24-hour urine collection as the reference test. GFR was calculated using cystatin ...
Lackovic Vesna - - 2012
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited vascular disorder caused by Notch3 gene mutations. The main histopathological hallmark is granular osmiophilic material (GOM) deposited in the close vicinity of vascular smooth muscle cells (VSMCs). The authors report the first 7 ultrastructurally and genetically confirmed ...
Antolín Albert A - - 2012
Small molecules are widely used in chemical biology without complete knowledge of their target profile, at risk of deriving conclusions that ignore potential confounding effects from unknown off-target interactions. The prediction and further experimental confirmation of novel affinities for PJ34 on Pim1 (IC50 = 3.7 µM) and Pim2 (IC50 = ...
Miguel Ana - - 2012
PURPOSE: To evaluate a methodology for adverse drug reactions (ADRs) detection through hospital databases. METHODS: A retrospective analysis was conducted to identify ADRs using diagnostic codes from databases, later validated by chart review. An independent chart review was performed for comparison, as well as assessment of spontaneous reports. RESULTS: 325 ...
Granqvist Emma E Computational and Systems Biology, John Innes Centre, Norwich NR4 7UH, United - - 2012
Legumes form symbioses with rhizobial bacteria and arbuscular mycorrhizal fungi that aid plant nutrition. A critical component in the establishment of these symbioses is nuclear-localized calcium (Ca(2+)) oscillations. Different components on the nuclear envelope have been identified as being required for the generation of the Ca(2+) oscillations. Among these an ...
Vanderdrift Laura E - - 2012
According to major theories of behavioral prediction, the most proximal psychological predictor of an individual's behavior is that individual's intention. With respect to interdependent behaviors such as condom use, however, relationship dynamics influence individuals' power to make decisions and to act. Objective: The current study examines how relationship dynamics impact ...
Tokuda Haruhiko - - 2012
To clarify the mechanism underlying a high risk of thrombotic complications in diabetic patients, we investigated the relationship between HSP27 phosphorylation and the platelet activation induced by adenosine diphosphate (ADP) in diabetic patients. Platelet-rich plasma was prepared from the blood of type 2 diabetes mellitus (DM) patients. By measuring the ...
Wang Xiaobin - - 2012
Radioresistance is responsible for treatment failure after radiotherapy in localized prostate cancer, while prostate cancer stem cells promote radioresistance by preferential activation of the DNA damage response. Chk1 inhibition has been shown to sensitize many tumor cells to radiation. However, whether Chk1 inhibition can potentiate the cytotoxic effects of radiation ...
Xie Hua - - 2012
Bimetallic clusters of AgCu-, AgCu2- and Ag2Cu- are investigated using photoelectron imaging and theoretical calculations. Their photoelectron spectra have been obtained at the wavelength of 355 nm and that of AgCu- is also acquired at 1064 nm. The ground state vertical detachment energies of these three clusters are measured to ...
Corrales Leticia - - 2012
The complement system contributes to various immune and inflammatory diseases, including cancer. In this study, we investigated the capacity of lung cancer cells to activate complement and characterized the consequences of complement activation on tumor progression. We focused our study on the production and role of the anaphylatoxin C5a, a ...
Miroddi Marco - - 2012
Extracts of the plant Serenoa repens are widely used in male adults for the treatment of benign prostatic hyperplasia. Recently, therapy with S repens has been proposed as a "natural" alternative to conventional treatments for male androgenetic alopecia as well as for other hair disorders. Telogen effluvium is a form ...
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