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Wang Feiyue - - 2012
Mercury is a major contaminant in the Arctic marine ecosystem. While extensive studies have been conducted on mercury in the Arctic's atmosphere and biota, far less is known about the distribution and dynamics of mercury species in the Arctic Ocean. Here we present vertical profiles for total mercury (HgT) and ...
Zhang Haiyang - - 2012
Electrostatic- and van der Waals interactions as well as entropy contribute to the energetics governing macromolecular complexation in biomolecules. Hydrogen bonds play a particularly important role in such interactions. Here we use molecular dynamics (MD) simulations to investigate the hydrogen bond (HB) orientations of free beta-cyclodextrin (β-CD) and head-to-head dimerization ...
Matos Marinez Farana - - 2012
Abstract Background: Abdominal obesity increases the risk of venous thromboembolism (VTE). It remains unclear to what extent inflammation contributes to the risk of VTE from abdominal obesity. Our objectives were to investigate the association between abdominal obesity and VTE and the effect of inflammation on this association in a case-control ...
Pasquali Sara K SK Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA. - - 2012
Clinical trials are the gold standard for generating evidence-based knowledge in medicine. Recent legislation requiring trials to be registered at ClinicalTrials.gov has enabled evaluation of the clinical trial enterprise as a whole, which was previously not possible. The purpose of this study was to create a snapshot of the pediatric ...
Lapin Dmitry - - 2012
Most natural Arabidopsis thaliana accessions are susceptible to one or more isolates of the downy mildew pathogen Hyaloperonospora arabidopsidis (Hpa). However, Arabidopsis C24 has proved resistant to all Hpa isolates tested so far. Here we describe the complex genetic basis of broad-spectrum resistance in C24. The genetics of C24 resistance ...
Rajarathinam Balakrishnan - - 2012
Synthesis of the 2-aza analogues of the pyrrolizidine alkaloid motif with two contiguous stereocenters has been achieved with high regio-, chemo-, and diastereoselectivity by an innovative multicomponent reaction in water. This elegant tactic has integrated the principles of privileged substructure-based Diversity Oriented Synthesis (pDOS) and Biology Oriented Synthesis (BIOS) to ...
Ferreira Sandra M - - 2012
Purpose:  The goal of the present study is to establish the antioxidant status in the brain of a high pressure-induced rat model. Methods:  Ocular hypertension was induced in rats (n = 12) cauterizing two episcleral veins under a surgical microscope. A sham procedure (n = 12) was performed in the control group. The markers ...
Foulon Brianne L - - 2012
The purpose of this study was to determine preferences of people with spinal cord injury (SCI) and health care professionals (HCP) regarding the content and format of a SCI physical activity guide to support recently released SCI physical activity guidelines. Seventy-eight people with SCI and 80 HCP completed a survey ...
Wergin Rachel - - 2012
Cognitive impairment occurs in up to one-third of intensive care patients and may affect one or more cognitive domains. Because data are scarce on therapies for this complication, prevention remains the prevailing strategy. In this review, we discuss the clinical approach to cognitive impairment after an intensive care unit (ICU) ...
McGowan Claire - - 2012
Critical care providers are often privy to confidential information in the course of clinical practice. A dilemma can arise when confidential information is requested by family members or friends of the patient. Critical care nurses must be aware of the regulations regarding confidentiality, as well as situations where the use ...
El-Khoury Lara H - - 2012
Following a severe hardship for the past 4 decades, the Iraqi Ministry of Health initiated many activities to enhance the knowledge and skills of health professionals. The American University of Beirut was approached to deliver a workshop to update the skills of Iraqi physicians in constructing an Objective Structured Clinical ...
Pal Sudipta Sarkar - - 2012
We propose a simple optical fiber tip for field-enhanced second harmonic generation (SHG). The tip shows nonlinear phenomena of SHG over a wide range of sources, at least from 630 to 830 nm. The optical field corresponding to the second harmonic appears as a nondiffracting bottle beam with voids due to ...
Jiang Jimmy J - - 2012
Avascular necrosis of the femoral condyle is an uncommon but serious sequela in patients who have received chemotherapy or corticosteroid treatment. The optimal treatment of avascular necrosis of the femoral condyles in pediatric patients is not well established. Nonoperative management has had limited long-term success, and many of the surgical ...
de Pádua Netto M V - - 2012
Cardiovascular disease is responsible for much of the mortality and morbidity observed in the renal transplant population. Some studies have applied the Framingham score mainly to the chronic kidney disease (CKD) on renal replacement therapy in an attempt to predict cardiovascular events, but the results underestimated the risk. It became ...
Perrino Carmen M - - 2012
Adrenal cortical tumors clinically mimicking pheochromocytomas are extremely rare, with 14 cases in the literature. The authors describe 2 patients with adrenal cortical adenoma (ACA) and catecholamine elevations. The impact of tissue preparation methods on electron microscopy (EM) images was assessed in ACA mimicking pheochromocytoma, pheochromocytoma, and ACA lacking pheochromocytoma-like ...
Paudel Mukesh Sharma - - 2012
Background: There have been many studies to estimate the incidence of acute kidney injury (AKI) in critically ill patients. However, results were variable due to the non-usage of uniform criteria and retrospective design of most studies. There are no new studies from the developing countries looking at AKI in these ...
Salzano Marcella - - 2012
Hashimoto's thyroiditis (HT) is the most frequent autoimmune disorder, characterized by the presence of a large lymphocytic infiltration and secretion of inflammatory cytokines in the thyroid. Infiltrating lymphocytes and cytokines play a pivotal role in the progression of HT, characterized by the progressive destruction of the normal follicular architecture of ...
Ritz Thomas - - 2012
Objective: This review examines the evidence for psychosocial influences in asthma and behavioral medicine approaches to its treatment. Method: We conducted a systematic review of the literature on psychosocial influences and the evidence for behavioral interventions in asthma with a focus on research in the past 10 years and clinical ...
Amijee Hozefa - - 2012
Oligomeric forms of β-amyloid (Aβ) have potent neurotoxic activity and are the primary cause of neuronal injury and cell death in Alzheimer's disease (AD). Compounds that perturb oligomer formation or structure may therefore be therapeutic for AD. We previously reported that D-[(chGly)-(Tyr)-(chGly)-(chGly)-(mLeu)]-NH2 (SEN304) is able to inhibit Aβ aggregation and ...
Chalhoub Viviane - - 2012
OBJECTIVE To highlight the possible association of intracranial aneurysm with autosomal recessive polycystic kidney disease. DESIGN, SETTING, AND PATIENT To our knowledge, this association has been reported only twice in the medical literature. We herein report the case of a 21-year-old man with autosomal recessive polycystic kidney disease, presenting with ...
Weatherup Robert S - - 2012
Low temperature (~600°C), scalable chemical vapor deposition of high quality, uniform mono-layer graphene is demonstrated with a mapped Raman 2D/G ratio of >3.2, D/G ratio ≤ 0.08 and carrier mobilities of ≥ 3000cm2V-1s-1 on SiO2 support. A kinetic growth model for graphene CVD based on flux balances is established, which ...
Keenan Kathryn E KE Department of Mechanical Engineering, Stanford University, Stanford, CA, - - 2013
Cartilage material properties provide important insights into joint health, and cartilage material models are used in whole-joint finite element models. Although the biphasic model representing experimental creep indentation tests is commonly used to characterize cartilage, cartilage short-term response to loading is generally not characterized using the biphasic model. The purpose ...
Li Hong - - 2012
To investigate how N-fertilization affects the growth, carbon and nitrogen (N) physiology, and wood properties of poplars with contrasting growth characteristics, slow-growing (Populus popularis, Pp) and fast-growing (P. alba×P. glandulosa, Pg) poplar saplings were exposed to different N levels. Above-ground biomass, leaf area, photosynthetic rates (A), instantaneous photosynthetic nitrogen use ...
Yu Jing-Hua - - 2012
• Premise of the study: Thirteen polymorphic microsatellite markers were developed to investigate the genetic diversity and population structure of Pinus koraiensis.• Methods and Results: Using the Fast Isolation by AFLP of Sequences COntaining repeats (FIASCO) method with three specific PCR primers for screening the positive clones, 13 loci were ...
Martins David - - 2012
African Americans have a disproportionate burden of chronic kidney disease (CKD), which tends to have an earlier onset and a more rapid progression in this population. Many of the factors responsible for the rapid progression of CKD in African Americans are detectable by screening and are modifiable with prompt therapy.
Tong Sebastian T C - - 2012
Students are increasingly participating in international health experiences during their medical training. This essay explores one student's perspective on the importance of relationship development with both patients and health care systems in global settings. The essay also reflects on the unique learning experiences available in resource-limited areas.
Kennedy Jeffrey D - - 2012
SUMMARY:: Neocortical temporal lobe epilepsy (NTLE) comprises a heterogeneous group of epilepsies with focal seizures characterized by auditory, somatosensory, or psychic auras followed by motionless staring, early contralateral clonic activity often secondarily generalizing. Neurophysiologic findings in NTLE are typically a predominance of lateral temporal interictal epileptiform activity (IEA) and an ...
Feng Shaoqi - - 2012
We report silicon waveguide butt-coupled p-i-n InGaAs photodetectors epitaxially grown on silicon-on-insulator substrates by metalorganic chemical vapor deposition. The InGaAs absorption layer that is lattice-matched to InP is selectively grown on patterned SOI substrates, employing metamorphic growth of GaAs and InP buffer layers. We measure a dark current of 2.5 μA ...
Bachoura Abdo - - 2012
Ulnar tunnel syndrome could be broadly defined as a compressive neuropathy of the ulnar nerve at the level of the wrist. The ulnar tunnel, or Guyon's canal, has a complex and variable anatomy. Various factors may precipitate the onset of ulnar tunnel syndrome. Patient presentation depends on the anatomic zone ...
Cha Jang Gyu - - 2012
Pilomatricoma, also known as calcifying epithelioma of Malherbe, is an asymptomatic, slow-growing, benign dermal neoplasm that originates from hair cortex cells. The most common sites are the head and neck (68.2%), followed by the trunk (14.4%) and the upper (15.3%) and lower (2%) extremities. The majority (60%-70%) of tumors develop ...
Neves M - - 2012
Accumulation of C4d along peritubular capillaries (PTC) of renal allografts is normally attributed to antibody-mediated rejection. The prognostic implication of these deposits associated with "cell-mediated" rejection on graft survival remains uncertain. Our study aims to evaluate the impact of C4d deposits along PTC of patients with acute cell- mediated rejection ...
Fabbri Raffaella - - 2012
The aim of this study was to evaluate the effects of FSH and LH on follicle development during a long-term culture of cryopreserved human ovarian tissue, using morphological and ultrastructural examinations. Thawed ovarian tissue slices from a 4-year-old child with Wilms tumor were cultured for 32 weeks in two different ...
Norja Päivi - - 2012
The introduction of dual viral inactivation of clotting factor concentrates has practically eliminated infections by viruses associated with significant pathogenicity over the last 20 years. Despite this, theoretical concerns about transmission of infection have remained, as it is known that currently available viral inactivation methods are unable to eliminate parvovirus B19 ...
Prantner Daniel D Department of Microbiology and Immunology, University of Maryland, School of Medicine (UMB), Baltimore, Maryland 21201, - - 2012
The chemotherapeutic agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a potent inducer of type I IFNs and other cytokines. This ability is essential for its chemotherapeutic benefit in a mouse cancer model and suggests that it might also be useful as an antiviral agent. However, the mechanism underlying DMXAA-induced type I IFNs, ...
Hamisch Domenica - - 2012
High concentrations of sulfur dioxide (SO(2) ) as an air pollutant, and its derivative sulfite, cause abiotic stress that can lead to cell death. It is currently unknown to what extent plant fumigation triggers specific transcriptional responses. To address this question, and to test the hypothesis that sulfite oxidase (SO) ...
Vasilescu Dragoş M - - 2012
Establishing the 3D architecture and morphometry of the intact pulmonary acinus is an essential step toward a more complete understanding of the relationship of lung structure and function. We combined a special fixation method with a unique volumetric nondestructive imaging technique and image processing tools to separate individual acini in ...
Singh Bhupendra B Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Room 5251, Kansas City, MO 64108, - - 2012
Epidemiological data and studies in rodent models strongly support the role of estrogens in the development of breast cancers. Oxidative stress has been implicated in this carcinogenic process. We have recently demonstrated that antioxidants vitamin C or butylated hydroxyanisole (BHA) severely inhibit 17β-estradiol (E2)-induced breast tumor development in female ACI ...
Carr Gavin G Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, - - 2012
Three new members of the angucycline class of antibiotics, pseudonocardones A-C (1-3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis ...
King K W - - 2012
Excess phosphorus, particularly in surface waters can lead to severe eutrophication. Identifying source areas, quantifying contributions, and evaluating management practices are required to address current and future water quality concerns. A before-after study was conducted from 2003-2010 on a sub-watershed of Northland Country Club Golf Course in Duluth, MN to ...
Lenker Heather K - - 2012
Dielectric heating has been successfully used in the preparation of a range of arylgold compounds. The approach is tolerant of a number of functional groups and rapidly generates the organometallic complexes in moderate to excellent yields.
Hejazi Rokhshad - - 2012
Traffic accidents are the reason for 25% of unnatural deaths in Iran. The main objective of this study is to find a simple model for the estimation of economic costs especially in Islamic countries (like Iran) in a straightforward manner. The model can show the magnitude of traffic accident costs ...
Grigoryan Marine - - 2012
BACKGROUND: - Glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) are hormones secreted by L and K cells respectively and by LK cells. To characterize L and K cells during development, we examined ileum from embryonic (e)- 12 to e-17. RESULTS: - GLP-1 cells were first seen at e-15 and ...
Vattathil Selina - - 2013
Due to limitations of surgical dissection and tumor heterogeneity, tumor samples collected for cancer genomics studies are often heavily diluted with normal tissue or contain subpopulations of cells harboring important aberrations. Methods for profiling tumor-associated allelic imbalance in such scenarios break down at aberrant cell proportions of 10%-15% and below. ...
- - 2012
The Specialty Guidelines for Forensic Psychology aim to improve the quality of forensic psychological services; enhance the practice and facilitate the systematic development of forensic psychology; encourage a high level of quality in professional practice; and encourage forensic practitioners to acknowledge and respect the rights of those they serve. These ...
Abrams Daniel - - 2012
Regional groundwater flow systems often contain both strong sinks and weak sinks. A strong sink extracts water from the entire aquifer depth, while a weak sink lets some water pass underneath or over the actual sink. The numerical groundwater flow model MODFLOW may allow a sink cell to act as ...
Lebigre Christophe - - 2012
The variance in fitness across population members can influence major evolutionary processes. In socially monogamous but genetically polygynandrous species, extra-pair paternity (EPP) is widely hypothesized to increase the variance in male fitness compared to that arising given the socially monogamous mating system. This hypothesis has not been definitively tested because ...
Liu Weixia - - 2012
Aspergillus biofilms were prepared from 22 strains of Aspergillus spp. via a 96-well plate-based method. Using a broth microdilution checkerboard technique with the XTT [2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] colorimetric assay, we demonstrated a synergistic antifungal activity against 18 of 22 Aspergillus biofilm strains with a combination of caspofungin and amphotericin B and against ...
Nadra Karim - - 2012
Through analysis of mice with spatially and temporally restricted inactivation of Lpin1, we characterized its cell autonomous function in both white (WAT) and brown (BAT) adipocyte development and maintenance. We observed that the lipin 1 inactivation in adipocytes of aP2(Cre/+)/Lp(fEx2)(-)(3/fEx2)(-)(3) mice resulted in lipodystrophy and the presence of adipocytes with ...
Chowdhury Pramit Kumar - - 2012
Crowding and confinement have often been used synonymously with regards to their effect on the structure and dynamics of proteins. In this work, we have investigated the unfolding of the protein myoglobin (Mb) entrapped in the confinement of the water pool of AOT reverse micelles and in presence of some ...
Wilson Paria Majd - - 2012
We report on a 21-day-old infant with healing posterior rib fractures that were noted after a chiropractic visit for colic. Chiropractors are the third largest group of health care professionals in the United States, and colic is the leading complaint for pediatric chiropractic care. Rib fractures, specifically when posterior, are ...
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